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Han Pill Song, Ji Yeon Jang, So Hyeon Bae, Seong Bong Choi, Byung Jo Yu, Moon Il Kim
Cerium oxide nanoparticles, also called nanoceria, have recently gained much attention as oxidase-mimicking nanozymes that catalyze the oxidation of chromogenic substrates for color generation without the addition of H2O2. Herein, we have developed a unique colorimetric biosensor for thrombin in human blood plasma, which relies on thrombin-binding aptamer (TBA)-mediated inhibition of the oxidase activity of nanoceria and its restoration by very selective interactions of TBA with target thrombin. In this system, nanoceria were first incubated with TBA, resulting in quick reduction of the oxidase activity of nanoceria via the adsorption of single-stranded (ss)DNA-type TBA on nanoceria...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Ju Chan Lee, Tae Jun Ahn, Yun Seop Yu
A source-overlapped dual-material gate TFET (SODM-TFET), which features different materials in its source-overlapped and channel gates, is proposed here, and its performance is investigated for various channel and source gate work functions (ψmc and ψms, respectively). Previous studies reported a hump effect in source-overlapped TFETs (SO-TFETs) and relatively high currents in the ambipolar state. The flat-band voltage in our SODM-TFET was controlled by modulating ψms and ψmc, allowing to reduce the hump effect and suppressing the ambipolar current...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Tea Jun Ahn, Yun Seop Yu
Two types of Ge/Si-based novel tunnel field-effect transistors (TFETs) with source pockets are proposed. In the proposed Ge/Si-based TFETs, the materials in the source, channel, and drain are Ge, Si, and Si, respectively, and the gate shortly overlaps the source. One of the proposed TFETs has an intrinsic Ge pocket and the other has an intrinsic Si pocket, shallowly doped in the source region below the source-overlapped gate. The current-voltage (I-V) characteristics of the proposed Ge/Si-based TFETs were simulated using the TCAD device simulator, and were compared with those of Si, Ge, and Ge (in source)/Si (in channel and drain) TFETs...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Linlin Li, Yizhang Zhang, Lei Zheng, Shaoyong Lu, Zhenguang Yan, Junhong Ling
The occurrence and distributions of simazine, and its environmental behaviors were studied in Taizi River, China. Results showed that concentration of simazine in surface water and suspended solids (SS) were in the range of 35-1150 ng L-1 and 0.00-1075 ng g-1 with mean value of 240.26 ng L-1 and 311.68 ng g-1 , respectively. A significant correlation between the concentrations of simazine and organic carbon was observed in both surface water and SS (r1  = 0.82, n1  = 15, r2  = 0...
April 5, 2018: Chemosphere
Hong Ju, JinZhuo Duan, Yuanfeng Yang, Ning Cao, Yan Li
The galvanic corrosion behavior of three metal alloys commonly used in water desalination plants was investigated using coupled multielectrode arrays consisting of aluminum-brass (HAl77-2), titanium alloy (TA2), and 316L stainless steel (316L SS). The three electrode types were coupled galvanically and arranged in different geometric configurations. Their corrosion behavior was characterized as a function of the chloride concentration. The potential and current distributions of the three-electrode coupling systems display electrochemical inhomogeneity...
April 20, 2018: Materials
SivaNaga S Anumolu, Sam Lindgren, Janardhana Vemula, David Floch, Christine Reynolds, Hans-Joachim Wallny, Haiying Sun
Canakinumab, a high-affinity human anti-interleukin-1β monoclonal antibody, is being used for the treatment of a broad spectrum of inflammatory diseases. This phase 1 study compared the relative bioavailability of a single dose of subcutaneous canakinumab either self-administered with an autoinjector (AI) or administered by a health care professional (HCP) with a prefilled safety syringe (SS) in healthy subjects. The study enrolled 80 subjects randomized 1:1 to receive 150 mg/mL of a liquid formulation of canakinumab via an AI or SS into either the thigh or abdomen...
April 20, 2018: Clinical Pharmacology in Drug Development
J M Fitzpatrick, D W Roberts, G Patlewicz
Predictive testing to characterise substances for their skin sensitisation potential has historically been based on animal models such as the Local Lymph Node Assay (LLNA) and the Guinea Pig Maximisation Test (GPMT). In recent years, EU regulations, have provided a strong incentive to develop non-animal alternatives, such as expert systems software. Here we selected three different types of expert systems: VEGA (statistical), Derek Nexus (knowledge-based) and TIMES-SS (hybrid), and evaluated their performance using two large sets of animal data: one set of 1249 substances from eChemportal and a second set of 515 substances from NICEATM...
April 20, 2018: SAR and QSAR in Environmental Research
Yu-Feng Chen, Xu-Feng Huang, Rui Gu, Shi-Hong Zhong, Xiao-Dong Wei
This article is aimed to study the response mechanism of Acanthopanax giraldii on different shading intensity to guide its artificial cultivation. The cultivated A. giraldii in Maoxian was used as the research object, set up different shading treatment groups, analyzed photosynthesis, physiology, submicroscopic structure to explore the response mechanism of A. giraldii to different light intensity. Light was the main influencing factor to photosynthetic rate.During morning and afternoon periods,the Pn of the CK group reduced by stomatal limitation and non stomatal limitation factors respectively...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Md Mofijul Islam, Sanjay Saha, Md Mahmudur Rahman, Swakkhar Shatabda, Dewan Md Farid, Abdollah Dehzangi
Glycation is chemical reaction by which sugar molecule bonds with a protein without the help of enzymes. This is often cause to many diseases and therefore the knowledge about glycation is very important. In this paper, we present iProtGly-SS, a protein lysine glycation site identification method based on features extracted from sequence and secondary structural information. In the experiments, we found the best feature groups combination: Amino Acid Composition, Secondary Structure Motifs and Polarity. We used support vector machine classifier to train our model and used an optimal set of features using a group based forward feature selection technique...
April 20, 2018: Proteins
Benjamin Louis Moresco, Clinton Woosley, Morris Sauter, Utpal Bhalala
Objectives: This study aimed to assess factors related to adherence to the Pediatric Advanced Life Support guidelines for severe sepsis and septic shock in an emergency room (ER) of a tertiary care children's hospital. Methods: This was a retrospective, observational study of children (0-18 years old) in The Children's Hospital of San Antonio ER over 1 year with the International Consensus Definition Codes, version-9 (ICD-9) diagnostic codes for "severe sepsis" and "shocks...
2018: Frontiers in Pediatrics
Matthias Salas, Marco Augustin, Franz Felberer, Andreas Wartak, Marie Laslandes, Laurin Ginner, Michael Niederleithner, Jason Ensher, Michael P Minneman, Rainer A Leitgeb, Wolfgang Drexler, Xavier Levecq, Ursula Schmidt-Erfurth, Michael Pircher
Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to 45° × 30°) of the human retina and choroid with standard resolution...
April 1, 2018: Biomedical Optics Express
Ashwinie A Ukuwela, Ashley I Bush, Anthony G Wedd, Zhiguang Xiao
Glutaredoxins (Grxs) are a family of glutathione (GSH)-dependent thiol-disulfide oxidoreductases. They feature GSH-binding sites that directly connect the reversible redox chemistry of protein thiols to the abundant cellular nonprotein thiol pool GSSG/GSH. This work studied the pathways for oxidation of protein dithiols P(SH)2 and reduction of protein disulfides P(SS) catalyzed by Homo sapiens HsGrx1 and Escherichia coli EcGrx1. The metal-binding domain HMA4n(SH)2 was chosen as substrate as it contains a solvent-exposed CysCys motif...
February 7, 2018: Chemical Science
Zeynep Selen Karalok, Birce Dilge Taskin, Alev Guven, Cemile Atilgan Ucgul, Omer Faruk Aydin
Susac's syndrome (SS) is a triad of encephalopathy, branch retinal artery occlusion (BRAO), and sensorineural hearing loss as a result of microvascular occlusions of the brain, retina, and inner ear. It is also a disorder of autoimmune endotheliopathy. SS usually affects young women between the age of 20 and 40 years. SS can be misdiagnosed as multiple sclerosis (MS) or acute disseminated encephalomyelitis (ADEM) because of similar findings. A 15-year-old girl presented in June 2015 with vomiting and severe headache...
October 2017: Journal of Pediatric Neurosciences
Ryohei Togashi, Hiroki Tanaka, Sakiko Nakamura, Hideo Yokota, Kota Tange, Yuta Nakai, Hiroki Yoshioka, Hideyoshi Harashima, Hidetaka Akita
Non-viral vectors are considered to be an attractive approach for gene delivery, since an artificial material is less immunogenic and oncogenic compared to a viral vector. We previously reported on the hepatic delivery of plasmid DNA (pDNA) by using lipid-like material (an SS-cleavable and pH-activated lipid-like material: ssPalm) which mounts two hydrophobic scaffolds, proton-accepting motifs (tertiary amines), and a cleavable unit (disulfide bonding). In the present study, we report on an advanced hepatic gene delivery system that uses a new type of ssPalm derivative: ssPalmE-Paz4-C2...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Ana Castro, Carla Moreira, Paulo Almeida, Norton de Matos, Luís Loureiro, Gabriela Teixeira, Duarte Rego, Sérgio Teixeira, Joaquim Pinheiro, Telmo Carvalho, Isabel Fonseca, José Queirós
BACKGROUND: The definition of significant stenosis (SS) remains controversial. METHODS: We retrospectively reviewed 1,040 consultations. SS was defined in the presence of clinical and echo-Doppler (DDU) criteria: Qa <500 mL/min or Qa decrease >25%; RI >0.7 in the feeding artery or absolute minimal luminal stenosis diameter <2.0 mm. Stenosis without any additional criteria were considered borderline stenosis (BS). RESULTS: Two hundred twenty-one arteriovenous fistulas (AVFs) were included: 58...
April 19, 2018: Blood Purification
Erdal Akturk, Lutfu Askin, M Hakan Tasolar, Serdar Turkmen, Hakan Kaya
OBJECTIVE: We evaluated the relationship between various risk scores (SYNTAX score (SS), SYNTAX score-II (SS-II), thrombolysis in myocardial infarction (TIMI) risk scores and Global Registry of Acute Coronary Events (GRACE) risk scores) and major adverse cardiovascular events (MACE) in non-ST-elevation myocardial infarction (NSTEMI) patients undergoing percutaneous coronary intervention (PCI). SUBJECTS AND METHODS: The study population were selected from among 589 patients who underwent coronary angiography with a diagnosis of NSTEMI...
April 19, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Juan Yue, Shi-Zhong Luo, Meng-Meng Lu, Dan Shao, Zheng Wang, Wen-Fei Dong
Mesoporous silica nanoparticles (MSNs) are promising drug carriers for use in cancer treatment owing to their excellent biocompatibility and drug loading capacity. However, MSN's incomplete drug release and toxic bioaccumulation phenomena limit their clinical application. Recently, researchers have presented redox responsive mesoporous organosilica nanoparticles containing disulfide (S-S) bridges (ss-MONs). These nanoparticles retained their ability to undergo structural degradation, and increased their local release activity when exposed to reducing agents...
April 19, 2018: Chemical Biology & Drug Design
Shabnam Ajami, Afshar-Rasti Boroujeni
Background: Torsions in rectangular wires are the essential part of corrections in the finishing stage of treatment. Moreover the greatest amounts of torques are applied in the molar areas. a clinically effective moment is between 5 and 20 Nmm. In this study we have decided to evaluate the impact of different tube sizes and different dimensions of wires with different modulus of elasticities on the amount torsional bond strength of molar tubes. Material and Methods: 60 human impacted molar teeth were collected...
January 2018: Journal of Clinical and Experimental Dentistry
Jieon Lee, Su-Jin Rhee, SeungHwan Lee, Kyung-Sang Yu
Objectives: As hypercholesterolemia is often accompanied by hypertension, statins are usually prescribed with angiotensin receptor blockers in clinical practice. This study was performed to evaluate the pharmacokinetics and safety of fimasartan and rosuvastatin when coadministered or administered alone as a single dose or as multiple doses to healthy Caucasians. Methods: Thirty-six subjects were enrolled into an open-labeled, randomized, 6-sequence, 3-period, 3-way crossover study, and randomly received fimasartan (120 mg), rosuvastatin (20 mg) or both...
2018: Drug Design, Development and Therapy
Huaxia Yang, Sainan Bian, Hua Chen, Li Wang, Lidan Zhao, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang
This study investigated the clinical characteristics and risk factors for overlapping rheumatoid arthritis and Sjögren's syndrome (RA/SS). Patients with RA/SS in Peking Union Medical College Hospital from January 2012 to January 2017 were retrospectively analysed and compared to those of sex- and age-matched RA or SS controls. Logistic regression analysis was used to identify risk factors. Altogether, 105 consecutive patients with RA/SS were enrolled. Ninety-seven (92.4%) of them were female, with a mean age of 51...
April 18, 2018: Scientific Reports
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