keyword
https://read.qxmd.com/read/38514023/role-of-mrna-binding-proteins-in-retinal-neovascularization
#21
REVIEW
Pei Lin, Wenye Cao, Xuemei Chen, Ningzhi Zhang, Yiqiao Xing, Ning Yang
Retinal neovascularization (RNV) is a pathological process that primarily occurs in diabetic retinopathy, retinopathy of prematurity, and retinal vein occlusion. It is a common yet debilitating clinical condition that culminates in blindness. Urgent efforts are required to explore more efficient and less limiting therapeutic strategies. Key RNA-binding proteins (RBPs), crucial for post-transcriptional regulation of gene expression by binding to RNAs, are closely correlated with RNV development. RBP-RNA interactions are altered during RNV...
March 19, 2024: Experimental Eye Research
https://read.qxmd.com/read/38512390/trends-in-the-prevalence-and-risk-factors-for-peripherally-inserted-central-catheter-related-complications-in-cancer-patients-from-2016-to-2022-a-multicenter-study
#22
JOURNAL ARTICLE
Shengxiao Nie, Lei Wang, Shengmiao Ma, Hong Sun
PURPOSE: To identify the trends in the prevalence of peripherally inserted central catheter (PICC) related complications in cancer patients and explore the risk factors for complications and occurrence speed. METHODS: A total of 3573 cancer patients with PICC were recruited at 17 hospitals from 2016 to 2022. Logistic and COX regression were performed to identify influencing factors of PICC-related complications and incidence speed, respectively. RESULTS: The proportion of symptomatic PICC-related thrombosis, phlebitis, and infections reported had decreased from 59...
March 21, 2024: Supportive Care in Cancer
https://read.qxmd.com/read/38511240/successful-management-of-fatal-cardiac-tamponade-resulting-from-intravascular-intervention-for-central-vein-occlusion-in-hemodialysis-patients-a-case-report
#23
JOURNAL ARTICLE
Wenhui Lei, Weidong Huang, Jun Xin
This case report highlights the successful management of fatal cardiac tamponade caused by intravascular intervention for central vein occlusion in hemodialysis patients. Prompt diagnosis and treatment are essential for patient prognosis in such cases. We present a case involving a challenging surgical procedure to address multiple complications, emphasizing the importance of early detection and appropriate interventions. The patient, who had a history of long-term central venous catheter use for hemodialysis, was diagnosed with central vein stenosis in addition to superior vena cava occlusion, hemodialysis catheter rupture, hypertension, and end-stage renal disease...
March 21, 2024: Journal of Vascular Access
https://read.qxmd.com/read/38510098/endovascular-release-of-an-adams-deweese-clip-and-iliocaval-reconstruction-for-debilitating-lower-extremity-swelling
#24
Eric Sung, Joel L Ramirez, Devin Zarkowsky
More than 10 million cases of venous thromboembolisms are reported on an annual basis and are major contributors to morbidity and mortality. Studies have found that ≤90% of pulmonary embolisms originate from the abdominal and lower extremity veins. The mainstay of venous thromboembolism treatment has been, and still continues to be, anticoagulation. However, for patients for whom anticoagulation is contraindicated or has failed, physicians have turned to surgical innovations such as inferior vena cava (IVC) filters to create partial interruption of the IVC...
June 2024: Journal of Vascular Surgery Cases and Innovative Techniques
https://read.qxmd.com/read/38510090/endovascular-mechanical-thrombectomy-of-iliofemoral-venous-stent-occlusion-with-the-novel-revcore-thrombectomy-system-case-reports-and-literature-review
#25
Christopher Montoya, Camilo Polania-Sandoval, Jose I Almeida
Venous in-stent restenosis is not completely understood, and the currently available treatment is usually unsatisfactory. We describe the cases of two patients treated with the RevCore thrombectomy system (Inari Medical), designed for venous in-stent thrombosis. Case 1 involves a 62-year-old woman with post-thrombotic syndrome from iliac vein stent placement 15 years earlier. Case 2 describes a 30-year-old woman with post-thrombotic syndrome from recurrent iliac vein stent occlusion, despite therapeutic anticoagulation...
June 2024: Journal of Vascular Surgery Cases and Innovative Techniques
https://read.qxmd.com/read/38509953/differences-in-collateral-vessel-formation-after-experimental-retinal-vein-occlusion-in-spontaneously-hypertensive-rats-and-wild-type-rats
#26
JOURNAL ARTICLE
Masatoshi Omi, Haruhiko Yamada, Hajime Takahashi, Hidetsugu Mori, Shimpei Oba, Yuki Hattori, Kaito Yokota, Keiko Toyama, Kanji Takahashi
OBJECTIVE: Retinal vein occlusion (RVO) can lead to visual impairment, but the development of collateral vessels can sometimes mitigate significant damage. This study aimed to investigate the relationship between collateral vessels and hypertension, the most common underlying condition associated with RVO, by comparing spontaneously hypertensive rats (SHRs) and wild-type Wister rats (WWRs). We also examined the differences between WWRs and SHRs in terms of sphingosine 1-phosphate receptor 1 (S1PR1) expression and its product nitric oxide synthase 3 (NOS3) expression, which are involved in the formation of collateral vessels after vascular occlusion...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38507597/influence-of-smoking-and-controlled-medical-conditions-on-the-risks-of-branch-retinal-vein-occlusion-in-south-korea-a-population-based-study
#27
JOURNAL ARTICLE
Jung Hoo Lee, Seong Ho Kim, EunAh Kim
PURPOSE: To evaluate the effect of controlled medical conditions and risk of lifetime smoking history on the prevalence of branch retinal vein occlusion (BRVO) based on the Korea National Health and Nutrition Survey (KNHANES) database from 2017-2021. METHODS: The study population consisted of individuals aged ≥ 40 years who had completed ophthalmological questionnaires, underwent comprehensive ophthalmological examinations, and had at least one good-quality readable fundus photograph...
March 20, 2024: Ophthalmic Epidemiology
https://read.qxmd.com/read/38504963/a-multicentric-cross-sectional-observational-study-to-analyze-the-effects-of-moderate-high-altitude-on-ocular-health
#28
JOURNAL ARTICLE
Vibhuti Maria, Sanat Kumar Khanna, Richa Chaudhary, Saurabh Maheshwari
OBJECTIVES: Prolonged exposure to hypoxia at high altitudes can affect the eyes through various mechanisms, culminating in reduced vision. Multiple studies on this subject have focused on the ocular effects of high altitude on intraocular pressure (IOP), corneal thickness, and the retina. However, there is a lack of literature on the effects of 'moderate high altitude (2000-3000 m)' on the eyes. Hence, we designed our study to determine the impact of moderate high altitude on the eyes...
2024: Beyoglu eye journal
https://read.qxmd.com/read/38500541/from-hair-loss-to-vision-loss-minoxidil-associated-crvo-in-a-young-female
#29
Lauren Pickel, Patrick Xiang Ji, Amr Abdelazim, Nirojini Sivachandran
INTRODUCTION: Central retinal vein occlusion (CRVO) is a common retinal vascular disorder that is most often seen in older adults and individuals with vascular risk factors. CASE PRESENTATION: We report a case of CRVO with cystoid macular edema (CME) in a young, otherwise healthy patient taking minoxidil for hair loss. The patient had no known vascular risk factors, and a comprehensive coagulability workup was negative. The CRVO with CME resolved without intervention upon cessation of minoxidil...
2024: Case Reports in Ophthalmology
https://read.qxmd.com/read/38499321/acute-spontaneous-vortex-vein-occlusion-clinical-features-multimodal-imaging-and-natural-course
#30
JOURNAL ARTICLE
Kang Xue, Fengxi Meng, Hui Ren, Han Yue, Lin Jonathan He, Ruiqi Ma, Xintong Lin, Jiang Qian, Jie Guo
AIMS: To describe the clinical features, multimodal imaging, treatments and natural course of acute spontaneous vortex vein occlusion. METHODS: Clinical data were collected on nine patients with acute vortex vein occlusion. The symptoms and signs, multimodal imaging, treatments and follow-up results were summarised. RESULTS: Six patients (66.7%) were men and three (33.3%) were women. The mean age was 47.8±15.4 years. Patients were initially misdiagnosed as having choroidal tumour (66...
March 18, 2024: British Journal of Ophthalmology
https://read.qxmd.com/read/38498277/efficacy-safety-and-treatment-burden-of-aflibercept-2%C3%A2-mg-and-ranibizumab-in-retinal-vein-occlusion-a-systematic-review-and-meta-analysis
#31
JOURNAL ARTICLE
Jing Wu, Xiaoning He, Fang Qi, Zhan Zhao, Zhe Xu, Hong Yan
INTRODUCTION: This systematic review and meta-analysis aimed to provide an updated evidence base for clinical decision-making by comparing the efficacy and safety of aflibercept 2 mg and ranibizumab in treating retinal vein occlusion (RVO). METHODS: A systematic search was conducted using eight databases up to December 2021. Randomized controlled trials (RCTs) and real-world studies (RWSs) comparing aflibercept and ranibizumab in patients with RVO were evaluated...
March 18, 2024: Ophthalmology and Therapy
https://read.qxmd.com/read/38495594/a-new-surgical-approach-for-the-treatment-of-a-refractory-foveal-microaneurysm-a-case-report
#32
Hiroshi Tanaka, Kentaro Kojima, Takafumi Miyatani, Natsuki Kusada, Nobuhiro Terao, Kenji Nagata, Chie Sotozono
PURPOSE: To report a case of a refractory foveal microaneurysm (MA) that was successfully treated by use of a new surgical procedure. OBSERVATIONS: This study involved a 79-year-old female with an active foveal MA associated with branch retinal vein occlusion in her left eye. Despite anti-vascular endothelial growth factor treatments, the MA remained active without closure, and best-corrected visual acuity (VA) gradually decreased from 20/20 to 20/200. After our new surgical procedure was explained in detail to the patient, written informed consent was obtained from the patient and the surgery was performed...
June 2024: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/38485215/using-artificial-intelligence-to-improve-human-performance-efficient-retinal-disease-detection-training-with-synthetic-images
#33
JOURNAL ARTICLE
Hitoshi Tabuchi, Justin Engelmann, Fumiatsu Maeda, Ryo Nishikawa, Toshihiko Nagasawa, Tomofusa Yamauchi, Mao Tanabe, Masahiro Akada, Keita Kihara, Yasuyuki Nakae, Yoshiaki Kiuchi, Miguel O Bernabeu
BACKGROUND: Artificial intelligence (AI) in medical imaging diagnostics has huge potential, but human judgement is still indispensable. We propose an AI-aided teaching method that leverages generative AI to train students on many images while preserving patient privacy. METHODS: A web-based course was designed using 600 synthetic ultra-widefield (UWF) retinal images to teach students to detect disease in these images. The images were generated by stable diffusion, a large generative foundation model, which we fine-tuned with 6285 real UWF images from six categories: five retinal diseases (age-related macular degeneration, glaucoma, diabetic retinopathy, retinal detachment and retinal vein occlusion) and normal...
March 14, 2024: British Journal of Ophthalmology
https://read.qxmd.com/read/38482878/potential-mechanism-of-platelet-gpiib-iiia-and-fibrinogen-on-retinal-vein-occlusion
#34
JOURNAL ARTICLE
Hang Ren, Yueyue Sun, Yanting Li, Xianbin Yuan, Bo Jiang, Wei Zhang, Gaoqin Liu, Peirong Lu
PURPOSE: To explore the role of coagulation and fibrinolytic factors, and the potential mechanism of platelet aggregation in the pathogenesis of retinal vein occlusion. METHODS: Coagulation and fibrinolytic parameters in patients with retinal vein occlusion were determined using hemagglutinin and HISCL-5000. Relationships between these elevated parameters and factors representing typical clinical manifestations of retinal vein occlusion were examined, and these parameters were analyzed using a STRING database to indicate the potential role of platelet aggregation...
March 14, 2024: Current Eye Research
https://read.qxmd.com/read/38482168/laparoscopic-treatment-of-congenital-portosystemic-shunts-with-portal-pressure-measurement-and-portal-angiography-in-36-dogs
#35
JOURNAL ARTICLE
Jin Shigemoto, Yasuyuki Kaneko, Mitsunobu Kawazu, Kiyokazu Naganobu, Shidow Torisu
INTRODUCTION: Laparoscopic surgery is used for canine congenital extrahepatic portosystemic shunts (CEHPSS). However, outcomes of laparoscopic surgery involving simultaneous portal vein angiography and portal pressure measurement to attenuate or completely occlude the shunt vessel in canines remain unclear. This study aimed to evaluate outcomes and complications of laparoscopic portosystemic shunt occlusion (LAPSSO) for CEHPSS. METHODS: Between June 2014 and March 2021, data on dogs undergoing cellophane banding (CB) and complete occlusion of laparoscopically treated congenital extrahepatic port shunts were collected from hospital records...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38480837/initial-response-and-12-month-outcomes-after-commencing-dexamethasone-or-vascular-endothelial-growth-factor-inhibitors-for-retinal-vein-occlusion-in-the-frb-registry
#36
JOURNAL ARTICLE
Gonzaga Garay-Aramburu, Adrian Hunt, Carolina Arruabarrena, Hemal Mehta, Alessandro Invernizzi, Pierre-Henry Gabrielle, Tremeur Guillaumie, Benjamin Wolff, Mark C Gillies, Javier Zarranz-Ventura
To compare baseline characteristics, initial response and 12-month efficacy and safety outcomes in eyes with branch and central retinal vein occlusion (BRVO and CRVO) treated with dexamethasone implants (DEX) or anti-vascular endothelial growth factor (anti-VEGF) we performed a multi-centre, retrospective and observational study using Fight Retinal Blindness! Registry. Of 725 eligible eyes, 10% received DEX initially with very frequent adjunctive anti-VEGF (BRVO-DEX 49%, CRVO-DEX 60%). The primary outcome of mean adjusted change in VA at 12 months with DEX and anti-VEGF initiated groups were not statistically significantly different (BRVO: DEX + 6...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38479406/explant-of-an-infected-endo-trashed-ivc-filter-in-an-immunosuppressed-patient-with-chronically-occluded-iliocaval-stents
#37
JOURNAL ARTICLE
Alice Alexander, Andrew H Smith, Matthew Krantz, Robert Simon, Francis J Caputo, Jon G Quatromoni
BACKGROUND: In the absence of a contiguous bowel perforation or intraabdominal source, infection of a retained vena cava filter in an occluded IVC has never been described. OBJECTIVE: To describe a case of an infected IVC filter in a chronically occluded iliocaval segment. METHODS: Here we present a case of an immunosuppressed 35-year-old female with chronically occluded iliocaval stents and an extensive staphylococcus hominis infection of a previously endo-trashed Bard Eclipse® filter...
March 13, 2024: Vascular
https://read.qxmd.com/read/38474074/a-novel-rat-model-of-mild-pulmonary-hypertension-associated-with-pulmonary-venous-congestion-induced-by-left-pulmonary-vein-banding
#38
JOURNAL ARTICLE
Jonas Münks, Athiththan Yogeswaran, Tobiah Kevin Antoine, Leonhard Anton Blumrich, Peter Dorfmüller, Hossein Ardeschir Ghofrani, Birgit Assmus, Ralph Theo Schermuly, Akylbek Sydykov
Pulmonary hypertension (PH) associated with left heart disease (PH-LHD) is the most common form of PH. In PH-LHD, changes in the pulmonary vasculature are assumed to be mainly caused by pulmonary venous congestion. However, the underlying mechanisms of this form of PH are poorly understood. We aimed to establish a model of PH associated with pulmonary venous congestion. Wistar-Kyoto rats underwent partial occlusion of the left pulmonary vein to induce pulmonary venous congestion or sham surgery and were assessed at various time points post-surgery (3, 6, 9, 12 weeks)...
February 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472988/analysis-of-oct-scanning-parameters-in-amd-and-rvo
#39
JOURNAL ARTICLE
Claus von der Burchard, Johann Roider, Timo Kepp
Optical coherence tomography (OCT) is an extensively used imaging tool for disease monitoring in both age-related macular degeneration (AMD) and retinal vein occlusion (RVO). However, there is limited literature on minimum requirements of OCT settings for reliable biomarker detection. This study systematically investigates both the influence of scan size and interscan distance (ISD) on disease activity detection. We analyzed 80 OCT volumes of AMD patients and 12 OCT volumes of RVO patients for the presence of subretinal fluid (SRF), intraretinal fluid (IRF), and pigment epithelium detachment (PED)...
February 29, 2024: Diagnostics
https://read.qxmd.com/read/38471762/prolonged-venous-transit-on-perfusion-imaging-is-associated-with-higher-odds-of-mortality-in-successfully-reperfused-patients-with-large-vessel-occlusion-stroke
#40
JOURNAL ARTICLE
Vivek S Yedavalli, Manisha Koneru, Meisam Hoseinyazdi, Cynthia Greene, Dhairya A Lakhani, Risheng Xu, Licia P Luna, Justin M Caplan, Adam A Dmytriw, Adrien Guenego, Jeremy J Heit, Gregory W Albers, Max Wintermark, L Fernando Gonzalez, Victor C Urrutia, Judy Huang, Kambiz Nael, Richard Leigh, Elisabeth B Marsh, Argye E Hillis, Rafael H Llinas
BACKGROUND: Poor venous outflow (VO) profiles are associated with unfavorable outcomes in patients with acute ischemic stroke caused by large vessel occlusion (AIS-LVO), despite achieving successful reperfusion. The objective of this study is to assess the association between mortality and prolonged venous transit (PVT), a novel visual qualitative VO marker on CT perfusion (CTP) time to maximum (Tmax) maps. METHODS: We performed a retrospective analysis of prospectively collected data from consecutive adult patients with AIS-LVO with successful reperfusion (modified Thrombolysis in Cerebral Infarction 2b/2c/3)...
March 12, 2024: Journal of Neurointerventional Surgery
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