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Masayuki Inubushi, Mitsuaki Tatsumi, Yuka Yamamoto, Katsuhiko Kato, Tetsuya Tsujikawa, Ryuichi Nishii
Written by associate editors of the Annals of Nuclear Medicine, this invited review article is intended to offer our readers a condensed global view on the high-quality research work that has been published in Europe last year. We have divided this article into five sections. The first three sections from the oncology category include "[18 F]fluorodeoxyglucose (FDG) positron-emission tomography (PET) for therapy monitoring in malignant lymphoma", "[18 F]fluoromisonidazole (FMISO) PET for hypoxia", and "lymphoscintigraphy update"...
September 21, 2018: Annals of Nuclear Medicine
Sami Mamand, Rebecca L Allchin, Matthew J Ahearne, Simon D Wagner
Patients with peripheral T-cell lymphomas generally have poor clinical outcomes with conventional chemotherapy. Recent advances have demonstrated that a large subgroup of PTCL are derived from follicular helper (Tfh) T-cells. These cases show a characteristic pattern of gene expression, which includes high-level protein expression of interleukin-2-inducible kinase (ITK). ITK is a member of the TEC family of kinases and normally has essential functions in regulating T-cell receptor signalling and T-cell differentiation...
September 21, 2018: Scientific Reports
Tao Wu, Yong Yang, Su-Yu Zhu, Mei Shi, Hang Su, Ying Wang, Xia He, Li-Ming Xu, Zhi-Yong Yuan, Li-Ling Zhang, Gang Wu, Bao-Lin Qu, Li-Ting Qian, Xiao-Rong Hou, Fu-Quan Zhang, Yu-Jing Zhang, Yuan Zhu, Jian-Zhong Cao, Sheng-Min Lan, Jun-Xin Wu, Chen Hu, Shu-Nan Qi, Bo Chen, Ye-Xiong Li
This study evaluated the survival benefit of intensity-modulated radiation therapy (IMRT) compared with 3-dimension conformal radiation therapy (3D-CRT) in a large national cohort of patients with early-stage extranodal nasal-type natural killer/T-cell lymphoma (NKTCL). This retrospective study reviewed patients with early-stage NKTCL treated with high-dose radiation therapy (RT; ≥45 Gy) at 16 Chinese institutions. Patients were stratified into 1 of 4 risk groups based on the number of risk factors: low risk (no factors), intermediate-low risk (1 factor), intermediate-high risk (2 factors), and high-risk (3-5 factors)...
September 25, 2018: Blood Advances
Veronica Balatti, Luisa Tomasello, Laura Z Rassenti, Dario Veneziano, Giovanni Nigita, Huan-You Wang, John A Thorson, Thomas J Kipps, Yuri Pekarsky, Carlo M Croce
Chronic Lymphocytic Leukemia (CLL) is the most common adult leukemia. It is characterized by the accumulation of CD19+/CD5+ lymphocytes and can have variable outcomes. Richter syndrome (RS) is a lethal complication in CLL patients resulting in aggressive B-cell lymphomas. To date, there are no tests to predict RS occurrence. Since alterations in microRNA expression can predict development and progression of several cancers, we investigated whether dysregulation of specific microRNAs can predict RS in CLL patients...
September 21, 2018: Blood
Keisuke Oda, Nobuhiro Mori, Masayoshi Okumi, Miyuki Furusawa, Masashi Ishiguro, Kazuyuki Inoue, Satoshi Shuto, Kohei Unagami, Hideki Ishida, Kazunari Tanabe, Teruo Murakami
The cellular uptake of mizoribine (MZR), an immunosuppressant, and metabolism of MZR to MZR-5'- monophosphate (MZRP), an active metabolite, were evaluated in L5178Y-R mouse lymphoma cells and peripheral blood mononuclear cells (PBMCs) of rats and kidney transplant recipients (KTRs, n = 22). Real-time PCR analysis revealed the expression of ENT1 and ENT2 mRNAs, but not of CNTs, in L5178Y-R cells and rat's PBMCs. In L5178Y-R cells, the uptake of MZR was suppressed by adenosine, a substrate for ENT1 and ENT2, but not by 5-(4-nitrobenzyl)-6-thioinosine (0...
August 25, 2018: Drug Metabolism and Pharmacokinetics
Wen Zheng, Yuhuan Gao, Xiaoyan Ke, Weijing Zhang, Liping Su, Hanyun Ren, Ningjing Lin, Yan Xie, Meifeng Tu, Weiping Liu, Lingyan Ping, Zhitao Ying, Chen Zhang, Lijuan Deng, Xiaopei Wang, Yuqin Song, Jun Zhu
BACKGROUND: The combination of chemotherapy and L-asparaginase (L-ASP) treatment significantly increased survival rate in an adult patient with extranodal natural killer (NK)/T-cell lymphoma (NKTCL). However, hypersensitivity reactions of L-ASP in some patients limited its application. Polyethylene glycol-conjugated asparaginase (PEG-ASP) has a lower immunogenicity and longer circulating half-life than unconjugated L-ASP, and has been reported to be effective and well-tolerated in children with acute lymphoblastic leukemia...
September 21, 2018: BMC Cancer
Jie-Huei Wang, Yi-Hau Chen
BACKGROUND: The development of a disease is a complex process that may result from joint effects of multiple genes. In this article, we propose the overlapping group screening (OGS) approach to determining active genes and gene-gene interactions incorporating prior pathway information. The OGS method is developed to overcome the challenges in genome-wide data analysis that the number of the genes and gene-gene interactions is far greater than the sample size, and the pathways generally overlap with one another...
September 21, 2018: BMC Bioinformatics
Michael G Milligan, Elizabeth Bigger, Jeremy S Abramson, Aliyah R Sohani, Musimar Zola, Mukendi K A Kayembe, Heluf Medhin, Gita Suneja, Shahin Lockman, Bruce A Chabner, Scott L Dryden-Peterson
PURPOSE: Botswana has a high prevalence of HIV infection. Currently, there are few data regarding the sociodemographic factors, clinical characteristics, and outcomes of non-Hodgkin lymphoma (NHL)-an AIDS-defining cancer-in the country. PATIENTS AND METHODS: This study used a prospective cancer registry to identify patients with a new diagnosis of NHL reporting for specialty cancer care at three hospitals in Botswana between October 2010 and August 2016. Treatment patterns and clinical outcomes were analyzed...
September 2018: Journal of Global Oncology
Solomon Tessema Memirie, Mahlet Kifle Habtemariam, Mathewos Asefa, Biniyam Tefera Deressa, Getamesay Abayneh, Biniam Tsegaye, Mihiret Woldetinsae Abraha, Girma Ababi, Ahmedin Jemal, Timothy R Rebbeck, Stéphane Verguet
PURPOSE: Noncommunicable diseases, prominently cancer, have become the second leading cause of death in the adult population of Ethiopia. A population-based cancer registry has been used in Addis Ababa (the capital city) since 2011. Availability of up-to-date estimates on cancer incidence is important in guiding the national cancer control program in Ethiopia. METHODS: We obtained primary data on 8,539 patients from the Addis Ababa population-based cancer registry and supplemented by data on 1,648 cancer cases collected from six Ethiopian regions...
September 2018: Journal of Global Oncology
Samantha L Vogt, Moosa Patel, Tanvier Omar, Sugeshnee Pather, Neil Martinson, Richard Ambinder
No abstract text is available yet for this article.
September 2018: Journal of Global Oncology
Sidharth Totadri, Venkatraman Radhakrishnan, Trivadi S Ganesan, Prasanth Ganesan, Krishnarathnam Kannan, Kadur Mallaiah Lakshmipathy, Ganesarajah Selvaluxmy, Tenali Gnana Sagar
PURPOSE: Treating pediatric Hodgkin lymphoma (HL) involves a delicate balance between cure and reducing late toxicity. Fluorodeoxyglucose positron emission tomography (PET) combined with computed tomography (CT) identifies patients with early response to chemotherapy, for whom radiotherapy may be avoided. The role of PET-CT in upfront risk stratification and response-adapted treatment is evaluated in this study. METHODS: Patients with HL, who were younger than 18 years, were included...
September 2018: Journal of Global Oncology
Kristin Schroeder, Anthony Saxton, Jessica McDade, Christina Chao, Nestory Masalu, Colin Chao, Daniel S Wechsler, Beda Likonda, Nelson Chao
PURPOSE: The majority of new diagnoses of pediatric cancer are made in resource-poor countries, where survival rates range from 5% to 25% compared with 80% in high-resource countries. Multiple factors, including diagnostic and treatment capacities and complex socioeconomic factors, contribute to this variation. This study evaluated the available resources and outcomes for pediatric patients with cancer at the first oncology treatment center in northern Tanzania. METHODS: Qualitative interviews were completed from July to August 2015 to determine available staff, hospital, diagnostic, treatment, and supportive care resources...
September 2018: Journal of Global Oncology
Raymond B Mailhot Vega, Omar F Ishaq, Inaya Ahmed, Luis Rene, Beatriz E Amendola, Kenneth S Hu
PURPOSE: The International Lymphoma Radiation Oncology Group (ILROG) published consensus guidelines on the management of Hodgkin disease (HD) and nodal non-Hodgkin lymphoma (NHL), which became the most downloaded articles from International Journal of Radiation Oncology, Biology, and Physics. E-contouring workshops allow for interactive didactic sessions, allowing participants to see case-based contouring in real time. A pilot 1-hour curriculum was developed with the objective of reviewing ILROG guidelines for HD and NHL management with incorporation of e-contouring tools...
September 2018: Journal of Global Oncology
Manoj P Menon, Anna Coghill, Innocent O Mutyaba, Warren T Phipps, Fred M Okuku, John M Harlan, Jackson Orem, Corey Casper
PURPOSE: The HIV epidemic has contributed to the increasing incidence of cancer in sub-Saharan Africa, where most patients with cancer present at an advanced stage. However, improved access to HIV care and treatment centers in sub-Saharan Africa may facilitate earlier diagnosis of cancer among patients who are HIV positive. To test this hypothesis, we characterized the stage of cancer and evaluated the factors associated with advanced stage at presentation among patients in Uganda. METHODS: We conducted a retrospective analysis of adult patients with any of four specific cancers who presented for care in Kampala, Uganda, between 2003 and 2010...
September 2018: Journal of Global Oncology
Saadiya Javed Khan, Arjumand Ali Arshad, Mohammad Bilal Fayyaz, Islah Ud Din Mirza
PURPOSE: Posterior reversible encephalopathy syndrome (PRES) is associated with a range of medical conditions and medications. In this retrospective analysis, we present 19 pediatric patients with PRES who had undergone chemotherapy. METHODS: We identified four female and 15 male patients diagnosed with PRES on the basis of clinical and radiologic features. Patient charts were reviewed from January 2013 to June 2016 after authorization from the institutional review board...
September 2018: Journal of Global Oncology
Basem Jamal
PURPOSE: This meta-analysis aimed to review the published outcomes of parotid non-Hodgkin lymphoma (NHL) pertaining to different treatment modalities. MATERIALS AND METHODS: A total of 48 journal articles published between 1993 and 2015, comprising 742 cases of parotid NHL, were initially evaluated. In total, 108 patients from 12 studies who had sufficient data for analysis, including age, tumor histopathology, treatment modality, and outcome at final follow-up, were included...
September 2018: Journal of Global Oncology
Adi J Klil-Drori, Geffen Kleinstern, Rania Abu Seir, Lotan Choshen-Cohen, Ziad Abdeen, Elyan Hussein, Mohammad Aqel, Thomas Göen, Riki Perlman, Dina Ben-Yehuda, Ora Paltiel
Associations of organochlorine (OC) pesticides and polychlorinated biphenyls (PCBs) with non-Hodgkin lymphoma are controversial. We compared serum levels of 6 OC pesticides and 38 PCBs in Israeli Jews (IJ) and Palestinian Arabs (PA) and assessed possible associations with B-cell non-Hodgkin lymphoma (B-NHL). Ninety B-NHL cases (50 IJ and 40 PA) and 120 controls (65 IJ and 55 PA) were included. Median concentrations of analytes in controls were compared across ethnic groups using quantile regression, adjusting for age and sex...
September 14, 2018: Chemosphere
Badr AbdullGaffar, Tasnim Keloth
Primary sarcomas of the larynx are rare and miscellaneous. The most common is chondrosarcoma. Other sarcomas are very rare. Sarcomas can have heterogeneous morphologic features of spindle, small round, epithelioid, pleomorphic and giant cells. Laryngeal sarcomas may mimic carcinomas, lymphomas, small cell carcinoma, mesothelioma and melanoma. This imposes diagnostic challenges for unfamiliar pathologists particularly in small laryngeal biopsies. Our aim was to study the different types of sarcomas that can involve the larynx in our institution, to investigate their diagnostic challenges and potential pitfalls and to find helpful histologic clues to avoid misinterpretation and missed diagnosis...
September 14, 2018: Annals of Diagnostic Pathology
Jungang Deng, Ping Yu, Zhenlei Zhang, Jun Wang, Jinhua Cai, Na Wu, Hongbin Sun, Hong Liang, Feng Yang
To develop potential next-generation metal anticancer agents, we designed and synthesised five Cu(II) 2-pyridine-thiosemicarbazone complexes by modifying the hydrogen atom at the N-4 position of ligands, and then investigated their structure-activity relationships and anticancer mechanisms. Modification of the N-4 position with different groups caused significant differences in cellular uptake and produced superior antitumor activity. Cu complexes arrested the cell cycle at S phase, leading to down-regulation of levels of cyclin and cyclin-dependent kinases and up-regulation of expression of cyclin-dependent kinase inhibitors...
September 10, 2018: European Journal of Medicinal Chemistry
Woo Jin Lee, Kwang Hee Won, Jae Won Choi, Chong Hyun Won, Sung Eun Chang, Jee Ho Choi, Mi Woo Lee
BACKGROUND: Epstein-Barr virus (EBV) positivity frequently presents in patients with nodal angioimmunoblastic T-cell lymphoma (AITL). However, the presence of EBV in skin lesions and its clinicopathological significance have not been evaluated. OBJECTIVE: To analyze the clinical and histopathological features of cutaneous AITL and evaluate EBV-positivity in skin tissue and its effects on clinicopathological features of AITL. METHODS: Clinicopathological variables in patients with cutaneous AITL were analyzed and compared depending on EBV in situ hybridization status in skin lesions using the patients' medical records...
September 18, 2018: Journal of the American Academy of Dermatology
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