keyword
https://read.qxmd.com/read/38493364/lymphoblast-transcriptome-analysis-in-22q11-2-deletion-syndrome-individuals-with-schizophrenia-spectrum-disorder
#1
JOURNAL ARTICLE
Elena Michaelovsky, Miri Carmel, Doron Gothelf, Abraham Weizman
Objectives: 22q11.2 deletion is the most prominent risk factor for schizophrenia (SZ). The aim of the present study was to identify unique transcriptome profile for 22q11.2 deletion syndrome (DS)-related SZ spectrum disorder (SZ-SD). Methods: We performed RNA-Seq screening in lymphoblasts collected from 20 individuals with 22q11.2DS (10 men and 10 women, 4 of each sex with SZ-SD and 6 with no psychotic disorders (Np)). Results: Sex effect in RNA-Seq descriptive analysis led to separating the analyses between men and women...
March 17, 2024: World Journal of Biological Psychiatry
https://read.qxmd.com/read/38493362/assessing-the-impact-of-sex-on-high-frequency-repetitive-transcranial-magnetic-stimulation%C3%A2-s-clinical-response-in-schizophrenia-results-from-a-secondary-analysis
#2
JOURNAL ARTICLE
Mattia Campana, Thomas Schneider-Axmann, Thomas Wobrock, Berend Malchow, Berthold Langguth, Michael Landgrebe, Peter Eichhammer, Elmar Frank, Joachim Cordes, Wolfgang Wölwer, Wolfgang Gaebel, Georg Winterer, Göran Hajak, Christian Ohmann, Pablo E Verde, Marcella Rietschel, Raees Ahmed, Matin Mortazavi, Wolfgang Strube, Peter Falkai, Alkomiet Hasan, Elias Wagner
Background: The evidence for repetitive transcranial magnetic stimulation (rTMS) to treat negative symptoms in schizophrenia (SCZ) is increasing, although variable response rates remain a challenge. Subject´s sex critically influences rTMS´ treatment outcomes. Females with major depressive disorder are more likely to respond to rTMS, while SCZ data is scarce. Methods: Using data from the 'rTMS for the Treatment of Negative Symptoms in Schizophrenia' (RESIS) trial we assessed the impact of sex on rTMS´ clinical response rate from screening up to 105 days after intervention among SCZ patients...
March 17, 2024: World Journal of Biological Psychiatry
https://read.qxmd.com/read/38493300/agreement-between-measured-and-self-reported-physiological-strain-in-males-and-females-during-simulated-occupational-heat-stress
#3
JOURNAL ARTICLE
Fergus K O'Connor, Robert D Meade, Sean R Notley, Leonidas G Ioannou, Andreas D Flouris, Glen P Kenny
RATIONALE: Monitoring physiological strain is recommended to safeguard workers during heat exposure, but is logistically challenging. The perceptual strain index (PeSI) is a subjective estimate thought to reflect the physiological strain index (PSI) that requires no physiological monitoring. However, sex is known to influence perceptions of heat stress, potentially limiting the utility of the PeSI. OBJECTIVES: The objective of this study was to assess whether sex modifies the relationship between PeSI and PSI...
March 16, 2024: American Journal of Industrial Medicine
https://read.qxmd.com/read/38493236/predictors-of-health-related-quality-of-life-for-children-with-neurodevelopmental-conditions
#4
JOURNAL ARTICLE
Maryam Mahjoob, Robyn Cardy, Melanie Penner, Evdokia Anagnostou, Brendan F Andrade, Jennifer Crosbie, Elizabeth Kelley, Muhammad Ayub, Muhammad Ayub, Jessica Brian, Alana Iaboni, Russell Schachar, Stelios Georgiades, Rob Nicolson, Jessica Jones, Azadeh Kushki
Neurodevelopmental conditions can be associated with decreased health-related quality of life; however, the predictors of these outcomes remain largely unknown. We characterized the predictors of health-related quality of life (HRQoL) in a sample of neurodiverse children and youth. We used a cross-sectional subsample from the Province of Ontario Neurodevelopmental Disorders Network (POND) consisting of those children and young people in the POND dataset with complete study data (total n = 615; 31% female; age: 11...
March 16, 2024: Scientific Reports
https://read.qxmd.com/read/38493139/the-prevalence-of-sarcopenia-in-spondyloarthritis-patients-a-meta-analysis
#5
JOURNAL ARTICLE
Jiawen Hu, Yiwen Wang, Xiaojian Ji, Yinan Zhang, Kunpeng Li, Feng Huang
BACKGROUND: Spondyloarthritis (SpA) is a chronic inflammatory disorder that affects sacroiliac joints and spine, resulting in substantial disability. Sarcopenia, characterized by the loss of muscle mass and function, is a prevalent comorbidity in various chronic diseases. However, the exact prevalence of sarcopenia in SpA patients remains uncertain. The objective of this study is to conduct a systematic review and meta-analysis of the available literature to determine the prevalence of sarcopenia in SpA...
March 16, 2024: Arthritis Research & Therapy
https://read.qxmd.com/read/38493081/exertional-breathlessness-related-to-medical-conditions-in-middle-aged-people-the-population-based-scapis-study-of-more-than-25-000-men-and-women
#6
JOURNAL ARTICLE
Magnus Ekström, Josefin Sundh, Anders Andersson, Oskar Angerås, Anders Blomberg, Mats Börjesson, Kenneth Caidahl, Össur Ingi Emilsson, Jan Engvall, Erik Frykholm, Ludger Grote, Kristofer Hedman, Tomas Jernberg, Eva Lindberg, Andrei Malinovschi, André Nyberg, Eric Rullman, Jacob Sandberg, Magnus Sköld, Nikolai Stenfors, Johan Sundström, Hanan Tanash, Suneela Zaigham, Carl-Johan Carlhäll
BACKGROUND: Breathlessness is common in the population and can be related to a range of medical conditions. We aimed to evaluate the burden of breathlessness related to different medical conditions in a middle-aged population. METHODS: Cross-sectional analysis of the population-based Swedish CArdioPulmonary bioImage Study of adults aged 50-64 years. Breathlessness (modified Medical Research Council [mMRC] ≥ 2) was evaluated in relation to self-reported symptoms, stress, depression; physician-diagnosed conditions; measured body mass index (BMI), spirometry, venous haemoglobin concentration, coronary artery calcification and stenosis [computer tomography (CT) angiography], and pulmonary emphysema (high-resolution CT)...
March 16, 2024: Respiratory Research
https://read.qxmd.com/read/38493018/effects-of-age-dependent-hormonal-changes-and-estrogen-supplementation-on-voice-in-girls-with-anorexia-nervosa-preliminary-report
#7
JOURNAL ARTICLE
Barbara Maciejewska, Zofia Maciejewska-Szaniec, Bogna Małaczyńska, Aleksandra Rajewska-Rager, Michał Michalak, Piotr Iwanowski
INTRODUCTION: Human development includes lots of physical and emotional changes. The human voice depends on age. Voice production is a complex physiological and acoustic phenomenon that depends on many factors such as structure, hormone level, degree of fatigue or nutrition and hydration of the body, systemic diseases, and emotional state. All these factors can be present in anorexia nervosa (AN), such as excessive weight loss, generated hydro-electrolytic changes, nutritional deficiencies, hormonal disturbances in the function of the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary-thyroid axis, the hypothalamic-pituitary-ovarian axis, and emotional distress...
March 15, 2024: Journal of Voice
https://read.qxmd.com/read/38492849/not-all-patient-reported-outcome-measures-are-equivalent-at-two-compared-to-one-year-after-anterior-cruciate-ligament-reconstruction-based-on-a-retrospective-analysis
#8
JOURNAL ARTICLE
Alexander J Hoffer, Mark McConkey, Parth Lodhia, Jordan Leith
OBJECTIVE: To assess for clinically important differences in patient reported outcome measures (PROMs) at one- and two-years post anterior cruciate ligament reconstruction (ACLR). METHODS: A retrospective comparison of prospectively collected PROMs for a single cohort who underwent a primary ACLR with or without associated meniscal surgery from 2016 to 2020 was assessed. Six externally validated PROMs were collected pre-operatively and at standardized times post-operatively...
March 14, 2024: Journal of ISAKOS
https://read.qxmd.com/read/38492788/sex-differences-in-the-short-and-long-term-outcomes-following-rotational-atherectomy-a-meta-analysis
#9
JOURNAL ARTICLE
Song Peng Ang, Chayakrit Krittanawong, Muhammed Haris Usman, Jose Iglesias, Jia Ee Chia, Kanan Jahangirli, Temitope Akinyemi, Debabrata P Mukherjee
BACKGROUND: Rotational atherectomy (RA) is used to address complex calcified coronary lesions but data regarding the association between gender and outcomes of patients undergoing RA remained uncertain. We aimed to investigate the short and long-term outcomes of patients undergoing RA based on sex. METHODS: A systematic literature search was performed in PubMed, Embase and Cochrane databases from its inception until August 2023 for relevant studies. Endpoints were pooled using the DerSimonian and Laird random-effects model as odd ratio (OR) with 95% confidence intervals (CI)...
March 14, 2024: American Journal of Cardiology
https://read.qxmd.com/read/38492731/predicting-30-day-mortality-after-ruptured-abdominal-aortic-aneurysms-validation-of-the-harborview-risk-score-in-a-single-center-dutch-study-population
#10
JOURNAL ARTICLE
Shanti-Devi Maria Khargi, Annemijne Nelle Nelissen, Arvind Oemrawsingh, Hugo Thomas Christian Veger, Jan J Wever, Jeroen Johannes Wilhelmus Maria Brouwers, Randolph George Statius van Eps
OBJECTIVE: The Harborview Risk Score (HRS) was recently proposed as scoring tool to predict 30-day mortality in patients with ruptured abdominal aortic aneurysms (rAAA). The HRS assigns one point for each of the following preoperative characteristics: age >76 years, pH <7.2, creatinine level >2mg/dL (>176.8 μmol/L) and systolic blood pressure <70mmHg, resulting in scores from 0 to 4. The 30-day mortality risk increases with every point. Primarily, we aimed to validate the HRS for the first time in a Dutch study population...
March 14, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38492650/antidepressant-like-effects-of-hyperin-on-chronic-stress-induced-depressive-like-behaviors-in-mice-gut-microbiota-and-short-chain-fatty-acids
#11
JOURNAL ARTICLE
Aoqi Song, Ru Cheng, Jingjing Jiang, Han Qu, Zhenghua Wu, Feng Qian, Shuyu Shen, Liwen Zhang, Zhiyu Wang, Wenjuan Zhao, Yuefen Lou
BACKGROUND: The antidepressant effect of hyperoside (HYP), which is the main component of Hypericum perforatum, is not established. This study aimed to determine the effects of HYP on depression. METHODS: The antidepressant-like effect of HYP was studied in mice induced by chronic restraint stress (CRS). The effects of HYP on behavior, inflammation, neurotransmitters, gut microbiota, and short-chain fatty acids (SCFAs) were studied in CRS mice. RESULTS: HYP improved depressive-like behavior in mice induced by CRS...
March 14, 2024: Journal of Affective Disorders
https://read.qxmd.com/read/38492619/influence-of-age-and-sex-on-the-thickness-of-the-radial-artery-wall
#12
REVIEW
Misbaou Barry, Fatoumata Barry, Mesut Gun, Paul Padurean, Jean Fortuné Ikoli, Eric Havet, Bessem Gara Ali, Thierry Caus
OBJECTIVE: The aim of this study is to investigate whether there is a relationship between age or sex and the thickness of the radial artery wall. MATERIALS AND METHODS: We harvested human radial arteries from 48 cadavers (30 men and 18 women) in the anatomy laboratory. Histological sections of 3μm thickness were prepared at the Laboratory of Anatomy and Pathological Cytology, mounted on slides, and stained with hematoxylin-phloxine-safran, Masson's trichrome, and orcein...
March 14, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38492562/sex-differences-in-long-term-survival-after-total-arterial-coronary-artery-bypass-grafting
#13
JOURNAL ARTICLE
Justin Ren, Andrea Bowyer, David H Tian, Christopher M Reid, Bridget Hwang, Colin Royse, Doa El-Ansary, Alistair Royse
OBJECTIVES: It is uncertain if the evidence on improved long-term survival of total arterial coronary artery bypass grafting applies to in female patients. This study aims to compare the long-term survival outcomes of using total arterial revascularisation versus at least one saphenous vein graft separately for men and women. METHODS: This retrospective analysis of the Australian and New Zealand Society of Cardiac-Thoracic Surgical Database had administrative linkage to the National Death Index...
March 16, 2024: European Journal of Cardio-thoracic Surgery
https://read.qxmd.com/read/38492471/placentae-of-small-appropriately-grown-for-gestational-age-neonates-exhibit-sexually-dimorphic-transcriptomic-changes-representative-of-placental-insufficiency
#14
JOURNAL ARTICLE
Adam Ewing, Jessica L O'Callaghan, Sharon McCracken, Stacy Ellery, Martha Lappas, Olivia J Holland, Anthony Perkins, Zarqa Saif, Vicki L Clifton
INTRODUCTION: Previous studies have reported that neonates less than the 25th BWC especially if they were male, were more likely to be associated with birth complications suggesting small neonates often identified as appropriately grown are at risk of adverse outcomes. We have questioned whether smaller neonates not typically categorized as "small for gestational age" may not reach their genetically determined growth due to placental insufficiency. METHODS: RNA-Seq was performed on the Illumina NovaSeq 600 using term placentae from neonates that were less than the 10th birthweight centile (BWC) (n = 39), between the 10th and the 30th BWC (n = 15) or greater than the 30th BWC (n = 23)...
February 23, 2024: Placenta
https://read.qxmd.com/read/38492456/anticipating-interpersonal-sensitivity-a-predictive-model-for-early-intervention-in-psychological-disorders-in-college-students
#15
JOURNAL ARTICLE
Min Zhang, Kailei Yan, Yufeng Chen, Ruying Yu
Psychological disorders, notably social anxiety and depression, exert detrimental effects on university students, impeding academic achievement and overall development. Timely identification of interpersonal sensitivity becomes imperative to implement targeted support and interventions. This study selected 958 freshmen from higher education institutions in Zhejiang province as the research sample. Utilizing the runge-kutta search and elite levy spreading enhanced moth-flame optimization (MFO) in conjunction with the kernel extreme learning machine (KELM), we propose an efficient intelligent prediction model, namely bREMFO-KELM, for predicting the interpersonal sensitivity of college students...
March 7, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38492288/reproductive-endocrine-disruption-effect-and-mechanism-in-male-zebrafish-after-life-cycle-exposure-to-environmental-relevant-triclosan
#16
JOURNAL ARTICLE
Fan Wang
Triclosan (TCS) is a wide-spectrum antibacterial agent that is found in various water environments. It has been reported to have estrogenic effects. However, the impact of TCS exposure on the reproductive system of zebrafish (Danio rerio) throughout their life cycle is not well understood. In this study, zebrafish fertilized eggs were exposed to 0, 10, and 50 μg/L TCS for 120 days. The study investigated the effects of TCS exposure on brain and testis coefficients, the expression of genes related to the hypothalamus-pituitary-gonadal (HPG) axis, hormone levels, vitellogenin (VTG) content, histopathological sections, and performed RNA sequencing of male zebrafish...
March 13, 2024: Aquatic Toxicology
https://read.qxmd.com/read/38492264/-to-do-so-in-a-patient-centred-way-is-not-particularly-lucrative-the-effects-of-neoliberal-health-care-on-prep-implementation-and-delivery
#17
JOURNAL ARTICLE
Jad Sinno, Emerich Daroya, Alex Wells, Mark Hull, Nathan J Lachowsky, Darrell H S Tan, Daniel Grace
BACKGROUND: HIV pre-exposure prophylaxis (PrEP) is a highly effective biomedical intervention used by HIV-negative people to prevent HIV acquisition. Despite increased use of PrEP worldwide, several barriers to PrEP implementation have resulted in insufficient uptake, inadequate adherence, and frequent discontinuation. Our objective was to interrogate the social, political, and economic conditions shaping PrEP implementation and delivery among gay, bisexual, queer and other men who have sex with men (GBQM) in Ontario, Canada...
March 4, 2024: Social Science & Medicine
https://read.qxmd.com/read/38492263/serum-lipids-as-predictive-markers-for-death-by-suicide
#18
JOURNAL ARTICLE
C Hyung Keun Park, Daewook Kim, Bora Kim, Sang Jin Rhee, Sung Joon Cho, Yong Min Ahn
Serum lipid levels have been associated with an increased risk of suicidal behaviors. This retrospective cohort study aimed to investigate the association between serum lipid levels and death by suicide among suicide attempters according to sex. Suicide attempters visiting emergency departments between 2007 and 2011 were followed up until the date of all-cause death or December 31, 2012. Sex-stratified Cox proportional hazards regression and competing risk models were constructed to obtain the hazard ratios (HR) of serum lipid measures and suicide...
March 3, 2024: Psychiatry Research
https://read.qxmd.com/read/38492171/the-effect-of-surgical-time-on-perioperative-complications-in-adolescent-idiopathic-scoliosis-cases-a-propensity-score-analysis
#19
JOURNAL ARTICLE
McKenna C Noe, Daniel Hagaman, Brittany Sipp, Fahad Qureshi, Jonathan R Warren, Ellie Kaji, Ashley Sherman, Richard M Schwend
BACKGROUND: Posterior spinal instrumentation and fusion (PSIF) for adolescent idiopathic scoliosis (AIS) can be lengthy and complication-ridden. The aim of this study was to evaluate the effect of surgical time on perioperative complications in this procedure when controlling for confounding variables with propensity score analysis. METHODS: This was an IRB-approved review of electronic health records from 2010 to 2019 at a single tertiary care children's hospital...
March 16, 2024: Spine Deformity
https://read.qxmd.com/read/38492056/use-of-tryptic-peptide-maldi-mass-spectrometry-imaging-to-identify-the-spatial-proteomic-landscape-of-colorectal-cancer-liver-metastases
#20
JOURNAL ARTICLE
Celine Man Ying Li, Matthew T Briggs, Yea-Rin Lee, Teresa Tin, Clifford Young, John Pierides, Gurjeet Kaur, Paul Drew, Guy J Maddern, Peter Hoffmann, Manuela Klingler-Hoffmann, Kevin Fenix
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. CRC liver metastases (CRLM) are often resistant to conventional treatments, with high rates of recurrence. Therefore, it is crucial to identify biomarkers for CRLM patients that predict cancer progression. This study utilised matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) in combination with liquid chromatography-tandem mass spectrometry (LC-MS/MS) to spatially map the CRLM tumour proteome...
March 16, 2024: Clinical and Experimental Medicine
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