Bruno A Cardoso, Mafalda Duque, Ana Gírio, Rita Fragoso, Mariana L Oliveira, James R Allen, Leila R Martins, Nádia C Correia, André Bortolini Silveira, Alexandra Veloso, Shunsuke Kimura, Lisa Demoen, Filip Matthijssens, Sima Jeha, Cheng Cheng, Ching-Hon Pui, Ana R Grosso, João L Neto, Sérgio F De Almeida, Pieter Van Vlieberghe, Charles G Mullighan, J Andres Yunes, David M Langenau, Françoise Pflumio, João T Barata
CASZ1 is a conserved transcription factor involved in neural development, blood vessel assembly and heart morphogenesis. CASZ1 has been implicated in cancer, either suppressing or promoting tumor development depending on the tissue. However, the impact of CASZ1 on hematological tumors remains unknown. Here, we show that the T-cell oncogenic transcription factor TAL1 is a direct positive regulator of CASZ1, that T-cell acute lymphoblastic leukemia (T-ALL) samples at diagnosis overexpress CASZ1b isoform, and that CASZ1b expression in patient samples correlates with PI3KAKT- mTOR signaling pathway activation...
December 7, 2023: Haematologica