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Atypic dengue

Meenaxi Sharda, Anil Soni, Harish Nigam, Anuraj Singh, Nitasha Sharma
Acute scrotal edema associated with dengue fever is a rare and self limiting condition resolving in a few days without any complication or sequelae. We report two cases of dengue fever in father and son which presented simultaneously with acute scrotal edema.
October 2016: Journal of the Association of Physicians of India
D B Kadam, Sonali Salvi, Ajay Chandanwale
The World Health Organization (WHO) has coined the term expanded dengue to describe cases which do not fall into either dengue shock syndrome or dengue hemorrhagic fever. This has incorporated several atypical findings of dengue. Dengue virus has not been enlisted as a common etiological agent in several conditions like encephalitis, Guillain Barre syndrome. Moreover it is a great mimic of co-existing epidemics like Malaria, Chikungunya and Zika virus disease, which are also mosquito-borne diseases. The atypical manifestations noted in dengue can be mutisystemic and multifacetal...
July 2016: Journal of the Association of Physicians of India
Vasantha Kamath, Mahitha C, Bushra Bahjat
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
José-Luis Barnay, Andre Cabie, Sylvie Abel, Emilie Javelle, Odile Troisgros, Patrick René-Corail
Arboviruses cause very recurrent epidemics, the oldest Dengue, known especially outside the flu-like syndrome with high fever mainly impacting vulnerable populations, may be responsible for severe hemorrhagic fevers, but also a few cases of Guillain-Barré syndrome. In 2014, the French Antilles occurred an outbreak of Chikungunya, following that of the Reunion's outbreak. During this period have been described, the articular and musculo-squellettic lesions, responsible for loss of autonomy in populations already carriers of chronic inflammatory joint damage or mechanical, but also a heavy impact on the autonomy of elderly and frail people...
September 2016: Annals of Physical and Rehabilitation Medicine
Leslie Goo, Kimberly A Dowd, Alexander R Y Smith, Rebecca S Pelc, Christina R DeMaso, Theodore C Pierson
UNLABELLED: Zika virus (ZIKV) is a flavivirus that has emerged as a global health threat due in part to its association with congenital abnormalities. Other globally relevant flaviviruses include dengue virus (DENV) and West Nile virus (WNV). High-resolution structures of ZIKV reveal many similarities to DENV and suggest some differences, including an extended glycan loop (D. Sirohi, Z. Chen, L. Sun, T. Klose, T. C. Pierson, et al., 352:467-470, 2016,
2016: MBio
Andréia Moreira Dos Santos Carmo, Rodrigo Buzinaro Suzuki, Michele Marcondes Riquena, André Eterovic, Márcia Aparecida Sperança
BACKGROUND: Dengue fever (DF) outbreaks present regionally specific epidemiological and clinical characteristics. In certain medium-sized cities (100 000-250 000 inhabitants) of São Paulo State, Brazil, and after reaching an incidence of 150 cases/100 000 inhabitants ("epidemiological threshold"), clinical diagnosis indicated dengue virus (DENV) infection. During this period, other seasonally infectious diseases with symptoms and physical signs mimicking DF can simultaneously occur, with the consequential overcrowding of health care facilities as the principal drawbacks...
2016: Infectious Diseases of Poverty
Faizan Sheraz, Hassan Tahir, Jannavi Saqi, Vistasp Daruwalla
The majority of dengue viral infections are asymptomatic, though symptoms may range from self-limiting febrile illness to life threatening hemorrhagic manifestations. As the burden of disease is dramatically rising in recent years, more patients with atypical presentations and rare complications are increasingly reported. Dengue virus may rarely involve different organ systems including CNS, liver, and heart. However, involvement of eye and thyroid is extremely rare. We present a case of 32-year old patient who presented with conjunctivitis and subacute thyroiditis and was found to have dengue viral infection as the cause of these conditions...
June 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Isaac Farias Cansanção, Ana Paula Santos do Carmo, Robério Dias Leite, Silvia Helena Barem Rabenhorst
Dengue is an important infectious disease that has high morbidity and mortality rates in most tropical and subtropical areas of the world. The diversity of the clinical manifestations involved in the outcome of dengue virus infection is affected by the relationship between serotype/genotype of the virus, host immune status, host genetic background, and environmental factors. Polymorphisms in interleukin (IL) genes have been associated with risk of developing symptomatic dengue. This study aimed to determine the association of the single-nucleotide polymorphisms of IL1β -511C>T, IL1RN 86 bp VNTR, and IL6 -174G>C genes with the clinical features of 198 individuals admitted to the São José Infectious Diseases Hospital with suspected dengue infection...
July 2016: Viral Immunology
Yuan Liang Woon, Chee Peng Hor, Narwani Hussin, Ariza Zakaria, Pik Pin Goh, Wee Kooi Cheah
BACKGROUND: Dengue infection is the fastest spreading mosquito-borne viral disease, which affects people living in the tropical and subtropical countries. Malaysia had large dengue outbreaks in recent years. We aimed to study the demographics and clinical characteristics associated with dengue deaths in Malaysia. METHODS: We conducted a retrospective review on all dengue deaths that occurred nationwide between 1st January 2013 and 31st December 2014. Relevant data were extracted from mortality review reports and investigational forms...
May 2016: PLoS Neglected Tropical Diseases
Shenggen Wu, Yuwei Weng, Wenjing Ye, Linglan Wang, Yansheng Yan, Rongtao Hong, Jianming Ou, Wu Chen, Shaojian Cai
OBJECTIVE: A Dengue outbreak was reported in Dongfen town Jianou county, Fujian province on September 19, 2014. The goal of this project was to explore the role of syndromic surveillance program in the practice of early detection on disease outbreak through the case mentioned above. METHODS: The authors retrospectively collected data related to Outpatient log and Pharmacy drug use in Dongfen township hospital through the electronic information system of the hospital from August to November, 2014...
April 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Burke A Cunha, Rina Seerke Teper, Muhammad Raza
Travelers returning from the tropics with fever remain a diagnostic challenge. Fever and chills suggest malaria, but may be present in dengue, chikungunya and influenza, and splenomegaly favors malaria or typhoid fever. In terms of laboratory tests, leukopenia suggests dengue fever, chikungunya fever or influenza. Atypical lymphocytes are present in malaria, dengue fever, chikungunya fever and influenza HAV, but not typhoid fever. Thrombocytopenia is profound in dengue fever, is also present in influenza and malaria...
2016: IDCases
Manoj Lakhotia, Hans Raj Pahadiya, Ronak Gandhi, Gopal Raj Prajapati, Akanksha Choudhary
The hemophagocytic syndrome is an atypical and rare manifestation of dengue fever (DF). We describe a 15-year-old girl developing DF associated hemophagocytic syndrome who responded with supportive treatment.
January 2016: Indian Journal of Critical Care Medicine
Anisha Mohan, Siby Joseph, Neeraj Sidharthan, Dhanya Murali
UNLABELLED: A 47 year old lady with hyperthyroidism for past 1½ years was initially on Carbimazole 20 mg orally then changed to 30 mg (during Hysterectomy) but was taking 10 mg for last 1 year. She had intermittent fever with severe B/L bifrontal headache since 3 weeks. Routine investigations showed anaemia, neutropenia, leucopenia and CRP elevation. Peripheral smear showed normocytic normochromic anaemia with Rouleaux formation, leucopenia with 2% atypical cells and mild thrombocytosis...
October 2015: Journal of Pharmacology & Pharmacotherapeutics
Sriram Pothapregada, Banupriya Kamalakannan, Mahalakshmy Thulasingam
OBJECTIVES: To study the clinical profile and outcome of the atypical manifestations of dengue fever in children. METHODS: All children (0-12 y of age) diagnosed and confirmed as dengue fever at a tertiary care hospital at Puducherry, between the 1st of August 2012 and January 31st 2015 were reviewed retrospectively from hospital case records as per the revised World Health Organization (WHO) guidelines 2011 for dengue fever. The diagnosis was confirmed by NS1 antigen-based ELISA test or dengue serology for IgM and IgG antibodies and the data was analyzed using SPSS 16...
June 2016: Indian Journal of Pediatrics
Angel Balmaseda, Aubree Gordon, Lionel Gresh, Sergio Ojeda, Saira Saborio, Yolanda Tellez, Nery Sanchez, Guillermina Kuan, Eva Harris
Chikungunya virus (CHIKV) was recently introduced into the Americas. In Nicaragua, the first endogenous transmission of CHIKV was recognized in September 2014. We used an ongoing dengue cohort study of children aged 2-14 years in Managua, Nicaragua, to document the attack rate of symptomatic chikungunya in a presumably naive population. From September 2014 through March 2015, the overall clinical attack rate of laboratory-confirmed CHIKV infection was 2.9% (95% confidence interval [CI]: 2.3%, 3.4%). The attack rate was greater in children ≥ 8 years of age (4...
February 2016: American Journal of Tropical Medicine and Hygiene
Noely Hein, Gabriel Heiser Bergara, Nathalie Bianchini Vieira Moura, Débora Morais Cardoso, Maki Hirose, Angela Espósito Ferronato, Antônio Carlos Pastorino, Denise Swei Lo, Alfredo Elias Gilio
Dengue is endemic in more than 100 countries in Southeast Asia, the Americas, the western Pacific, Africa and the eastern Mediterranean regions. The virus is transmitted by Aedes mosquitoes. Dengue disease is the most prevalent arthropod-borne viral disease in humans and is a global and national public health concern in several countries. A seasonal pattern of dengue disease is consistently observed. The highest incidences usually correspond to the period of highest rainfall and humidity, providing suitable conditions for Aedes aegypti breeding and survival...
July 2015: Autopsy & case reports
Vipa Thanachartwet, Nittha Oer-Areemitr, Supat Chamnanchanunt, Duangjai Sahassananda, Akanitt Jittmittraphap, Plengsakoon Suwannakudt, Varunee Desakorn, Anan Wattanathum
BACKGROUND: Dengue is the most common mosquito-borne viral disease in humans. Recently, there has been an epidemic shift of dengue from mainly affecting children to affecting more adults with increased severity. However, clinical factors associated with severe dengue in adults have varied widely between studies. We aimed to identify the clinical factors associated with the development of severe dengue according to the World Health Organization (WHO)'s 2009 definition. METHODS: We conducted a prospective study of adults with dengue admitted to the Hospital for Tropical Diseases in Bangkok, Thailand, from October 2012 to December 2014...
2015: BMC Infectious Diseases
Sunil Sane, Asta Saulova, Rhiannon McLaren, Hayden White
With dengue fever emerging as a global health problem and more Australians travelling to endemic areas, imported dengue infection is on the rise and clinicians need to remain vigilant. Primary cardiac and neurologic involvement in dengue infection has been rarely described in the medical literature and the pathophysiology is poorly understood. A rare and fatal case of primary dengue infection in a 34-yearold woman who returned from Papua New Guinea is reported; the unusual features of this case include severe primary dengue infection, myocarditis, and acute cerebral oedema resulting in death...
2015: Australasian Medical Journal
Kashan Arshad, Saifuliah Sheikh, Syeda Umm-ul-Baneen Naqvi, Imran Sarwar, Sulman Javaid, Madiha Asghar, Muhammad Asghar Butt
BACKGROUND: Dengue Fever is caused by arthropod born viruses. According to World Health Organization approximately 50-100 million infections of dengue fever occur yearly. Objective of this study was to determine the frequency of splenomegaly in dengue fever in children. METHODS: This cross sectional study was conducted at the Department of Paediatrics, Allied Hospital, Faisalabad, during a period from June 2012 to May 2013 by including 93 Children, aged 4-14 years presenting with fever of less than 14 days with thrombocytopenia and positive IM or IgM and IgG dengue antibodies by ELISA...
April 2015: Journal of Ayub Medical College, Abbottabad: JAMC
Tun-Linn Thein, Ee-Ling Ng, Ming S Yeang, Yee-Sin Leo, David C Lye
BACKGROUND/PURPOSE: Bacteremia in dengue may occur with common exposure to pathogens in association with severe organ impairment or severe dengue, which may result in death. Cohort studies identifying risk factors for concurrent bacteremia among patients with dengue are rare. METHODS: We conducted a retrospective case-control study of adult patients with dengue who were admitted to the Department of Infectious Diseases at Tan Tock Seng Hospital, Singapore from 2004 to 2008...
August 4, 2015: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
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