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https://www.readbyqxmd.com/read/29791060/implementing-an-innovated-preservation-technology-the-american-society-of-transplant-surgeons-asts-standards-committee-white-paper-on-ex-situ-liver-machine-perfusion
#1
Cristino Quintini, Paulo Martins, Shimul Shah, Mary Killackey, Alan Reed, James Guarrera, David A Axelrod
The pervasive shortage of deceased donor liver allografts contributes to significant waitlist mortality despite efforts to increase organ donation. Ex-vivo liver perfusion appears to enhance preservation of donor organs, extending viability, and, potentially, evaluating function in organs previously considered too high risk for transplant. These devices pose novel challenges for organ allocation, safety, training, and finances. This White Paper describes the American Society of Transplant Surgeons' belief that organ preservation technology is a vital advance, but its use should not change fundamental aspects of organ allocation...
May 23, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29703944/an-integrative-analysis-of-non-coding-regulatory-dna-variations-associated-with-autism-spectrum-disorder
#2
Sarah M Williams, Joon Yong An, Janette Edson, Michelle Watts, Valentine Murigneux, Andrew J O Whitehouse, Colin J Jackson, Mark A Bellgrove, Alexandre S Cristino, Charles Claudianos
A number of genetic studies have identified rare protein-coding DNA variations associated with autism spectrum disorder (ASD), a neurodevelopmental disorder with significant genetic etiology and heterogeneity. In contrast, the contributions of functional, regulatory genetic variations that occur in the extensive non-protein-coding regions of the genome remain poorly understood. Here we developed a genome-wide analysis to identify the rare single nucleotide variants (SNVs) that occur in non-coding regions and determined the regulatory function and evolutionary conservation of these variants...
April 27, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29571257/tocoyena-sellowiana-extract-decreases-bone-loss-in-an-experimental-model-of-periodontitis-in-rats-putative-role-for-cyclooxygenase-2-and-il-1-inhibition
#3
Debora da Silva Freitas Ribeiro, Jordânia Marques de Oliveira Freire, Alrieta Henrique Teixeira, Danielle Rocha do Val, Alice Ramos de Freitas, Francisco Isaac Fernandes Gomes, Antonio Alfredo Rodrigues E Silva, Paulo Nogueira Bandeira, Helcio Silva Dos Santos, William Paulo Dos Santos, Fábio Nascimento Ávila, Karuza Maria Alves Pereira, Paula Goes, Vicente de Paulo Teixeira Pinto, Gerardo Cristino-Filho, Maria Rose Jane Ribeiro Albuquerque, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra
Tocoyena sellowiana (Cham. & Schltdl.) K.Schum is one of the most important families of Brazilian medicinal plants. This study aimed to evaluate the effect of Tocoyena sellowiana (Cham. & Schltdl.) K.Schum ethanolic extract in a pre-clinical trial of periodontitis and to investigate possible mechanisms underlying such effects. Periodontitis was induced in Wistar rats by placing a nylon thread ligature around second upper left molars for 11 days. Rats received (per os) Tocoyena sellowiana (0.1, 1 or 10?mg?kg) or vehicle 1?h before ligature and daily until day 11...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29529542/splenic-torsion-a-challenging-diagnosis-case-report-and-review-of-literature
#4
C Viana, H Cristino, C Veiga, P Leão
INTRODUCTION: Wandering spleen is an unusual condition characterized by hypermobility of the spleen. This is a rare clinical entity and it's more common in childhood under 1 year of age and in third decade of life. In this second peak, it's more frequent in females. Clinical manifestations can vary from asymptomatic to abdominal emergency. Treatment is often surgical. PRESENTATION OF CASE: We presented a case report of splenic torsion from our hospital and a review of cases described in literature...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29515040/a-peripheral-blood-transcriptomic-signature-predicts-autoantibody-development-in-infants-at-risk-of-type-1-diabetes
#5
Ahmed M Mehdi, Emma E Hamilton-Williams, Alexandre Cristino, Anette Ziegler, Ezio Bonifacio, Kim-Anh Le Cao, Mark Harris, Ranjeny Thomas
Autoimmune-mediated destruction of pancreatic islet β cells results in type 1 diabetes (T1D). Serum islet autoantibodies usually develop in genetically susceptible individuals in early childhood before T1D onset, with multiple islet autoantibodies predicting diabetes development. However, most at-risk children remain islet-antibody negative, and no test currently identifies those likely to seroconvert. We sought a genomic signature predicting seroconversion risk by integrating longitudinal peripheral blood gene expression profiles collected in high-risk children included in the BABYDIET and DIPP cohorts, of whom 50 seroconverted...
March 8, 2018: JCI Insight
https://www.readbyqxmd.com/read/29501769/the-efficacy-of-a-lectin-from-abelmoschus-esculentus-depends-on-central-opioid-receptor-activation-to-reduce-temporomandibular-joint-hypernociception-in-rats
#6
Shirley Moreira Alves, Raul Sousa Freitas, Danielle Rocha do Val, Lorena Vasconcelos Vieira, Ellen Lima de Assis, Francisco Isaac Fernandes Gomes, Carlos Alberto de Almeida Gadelha, Tatiane Santi Gadelha, José Thalles Jocelino Gomes de Lacerda, Juliana Trindade Clemente-Napimoga, Vicente de Paulo Teixeira Pinto, Gerardo Cristino Filho, Mirna Marques Bezerra, Hellíada Vasconcelos Chaves
Abelmoschus esculentus is largely cultivated in Northeastern Brazil for medicinal purposes, e.g. inflammatory conditions. This study aimed to evaluate the efficacy of Abelmoschus esculentus lectin (AEL) in reducing formalin-induced temporomandibular joint inflammatory hypernociception in rats. The behavioral experiments were performed in male Wistar rats (180-240 g). Rats were pre-treated (i.v.) with AEL (0.001, 0.01 or 0.1 mg/kg) 30 min before formalin injection (i.art.). To analyze the possible effect of opioid pathways on AEL efficacy, animals were pre-treated with naloxone or CTOP (μ opioid receptor antagonist), naltrindole (δ opioid receptor antagonist) or nor-binaltorphimine (κ opioid receptor antagonist) (i...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29362850/heme-oxygenase-1-biliverdin-carbon-monoxide-pathway-downregulates-hypernociception-in-rats-by-a-mechanism-dependent-on-cgmp-atp-sensitive-k-channels
#7
Hellíada Vasconcelos Chaves, Danielle Rocha do Val, Kátia Alves Ribeiro, Jonas Cavalcante Lemos, Ricardo Basto Souza, Francisco Isaac Fernandes Gomes, Rodrigo Maranguape Silva da Cunha, Vicente de Paulo Teixeira Pinto, Gerardo Cristino Filho, Marcellus Henrique Loiola Ponte de Souza, Mirna Marques Bezerra, Gerly Anne de Castro Brito
OBJECTIVE AND DESIGN: To investigate the role of heme oxygenase-1 (HO-1), carbon monoxide (CO), and biliverdin (BVD) in the zymosan-induced TMJ arthritis in rats. MATERIALS AND METHODS: Mechanical threshold was assessed before and 4 h after TMJ arthritis induction in rats. Cell influx, myeloperoxidase activity, and histological changes were measured in the TMJ lavages and tissues. Trigeminal ganglion and periarticular tissues were used for HO-1, TNF-α, and IL-1β mRNA time course expression and immunohistochemical analyses...
May 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29325419/a-new-method-of-infrared-fluorescence-enhanced-thoracoscopic-segmentectomy
#8
Ahmed G Elkhouly, Benedetto Cristino, Eugenio Pompeo
Optimal identification of the intersegmental plane can be challenging during thoracoscopic anatomical segmentectomy for lung cancer. We describe a simple new method of infrared-fluorescence-enhanced thoracoscopy with selected injection of indocyanine green into the bronchi not targeted for resection, which allows us to clearly identify the intersegmental plane in thoracoscopic segmentectomy.
March 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29289835/antinociceptive-anti-inflammatory-and-toxicological-evaluation-of-semi-synthetic-molecules-obtained-from-a-benzyl-isothiocyanate-isolated-from-moringa-oleifera-lam-in-a-temporomandibular-joint-inflammatory-hypernociception-model-in-rats
#9
Alain Oliveira Dos Santos, Danielle Rocha do Val, Felipe Dantas da Silveira, Francisco Isaac Fernandes Gomes, Hermany Capistrano Freitas, Ellen Lima de Assis, Diana Kelly Castro de Almeida, Igor Iuco Castro da Silva, Francisco Geraldo Barbosa, Jair Mafezoli, Marcos Reinaldo da Silva, Gerly Anne de Castro Brito, Juliana Trindade Clemente-Napimoga, Vicente de Paulo Teixeira de Paulo Teixera Pinto, Gerardo Cristino Filho, Mirna Marques Bezerra, Hellíada Vasconcelos Chaves
Inflammation is a key component of many clinical conditions that affect the temporomandibular joint (TMJ) and Moringa oleifera Lam. has been used to treat inflammatory diseases. Here, we evaluated the toxicological effects on mice of a naturally-occurring isothiocyanate from M. oleifera and its seven analogue molecules. Further, the anti-nociceptive and anti-inflammatory effects on a rat model of TMJ inflammatory hypernociception were assessed. The systemic toxicological profile was determined in mice over a 14-day period: MC-1 1 μg/kg; MC-D1 1 μg/kg, MC-D3 100 μg/kg, MC-D6 1 μg/kg, MC-D7 1 μg/kg, MC-D8 1 μg/kg, MC-D9 10 μg/kg, and MC-H 1 μg/kg...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29249988/-stemodia-maritima-l-extract-decreases-inflammation-oxidative-stress-and-alveolar-bone-loss-in-an-experimental-periodontitis-rat-model
#10
Alrieta H Teixeira, Jordânia M de Oliveira Freire, Luzia H T de Sousa, Antônia T Parente, Nayara A de Sousa, Angela M C Arriaga, Francisca R Lopes da Silva, Iracema M Melo, Igor I Castro da Silva, Karuza M A Pereira, Paula Goes, José J do Nascimento Costa, Gerardo Cristino-Filho, Vicente de Paulo T Pinto, Hellíada V Chaves, Mirna M Bezerra
Periodontitis is very prevalent worldwide and is one of the major causes of tooth loss in adults. About 80% of the worldwide population use medicinal plants for their health care. Stemodia maritima L. ( S. maritima ) antioxidant and antimicrobial effects in vitro as well as anti-inflammatory properties. Herein, the potential therapeutic effect of S. maritima was assessed in rats subjected to experimental periodontitis (EP). EP was induced in female Wistar rats by nylon thread ligature around 2nd upper left molars for 11 days...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29175669/euterpe-oleracea-mart-a%C3%A3-a%C3%A3-seed-extract-associated-with-exercise-training-reduces-hepatic-steatosis-in-type-2-diabetic-male-rats
#11
Graziele Freitas de Bem, Cristiane Aguiar da Costa, Viviane da Silva Cristino Cordeiro, Izabelle Barcellos Santos, Lenize Costa Reis Marins de Carvalho, Ricardo de Andrade Soares, Jéssica Honorato Ribeiro, Marcelo Augusto Vieira de Souza, Pergentino José da Cunha Sousa, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura
Type 2 diabetes mellitus contributes to an increased risk of metabolic and morphological changes in key organs, such as the liver. We aimed to assess the effect of the açaí seed extract (ASE) associated with exercise training on hepatic steatosis induced by high-fat (HF) diet plus streptozotocin (STZ) in rats. Type 2 diabetes was induced by feeding rats with HF diet (55% fat) for 5 weeks, followed by a single low dose of STZ (35 mg/kg i.p.). Control and diabetic groups were subdivided into four groups that were fed with standard chow diet for 4 weeks...
February 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29046296/geraniin-is-a-diuretic-by-inhibiting-the-na-k-2cl-cotransporter-nkcc2
#12
Erika Moreno, Juan A Gayosso, José R Montejano, Georgina Almaguer, Norma Vázquez, Cristino Cruz, Adriana Mercado, Norma A Bobadilla, Gerardo Gamba, Alfredo Sierra, Victoria Ramírez
Geranium seemannii Peyr is a perennial plant endemic to central Mexico that has been widely used for its diuretic effect, but the responsible compound of this effect is unknown as well as the mechanism by which the diuretic effect is achieved. Geraniin is one of the compounds isolated from this kind of geranium. This study was designed to determinate whether geraniin possesses diuretic activity and to elucidate the mechanism of action. Geraniin was extracted and purified from Geranium seemannii Peyr. Male Wistar rats were divided into four groups: 1) Control, 2) 75 mg/kg of geraniin, 3) 20 mg/kg of furosemide, and 4) 10 mg/kg of hydrochlorothiazide...
February 1, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29023550/effects-of-acute-alcohol-ingestion-on-eye-movements-and-cognition-a-double-blind-placebo-controlled-study
#13
Jéssica Bruna Santana Silva, Eva Dias Cristino, Natalia Leandro de Almeida, Paloma Cavalcante Bezerra de Medeiros, Natanael Antonio Dos Santos
Alcohol is one of the most consumed psychoactive substances in the world, and the negative impact related to alcohol use has become a worldwide public health issue. Alcohol is able to affect diffusely several areas of the Central Nervous System, which could impair visual functions, including eye movements, and cognitive processes. The objective of the present study was to investigate the effects of moderate alcohol intake in eyes movements, as an indicator of cognitive processing underlying the visual search in a the Maze task...
2017: PloS One
https://www.readbyqxmd.com/read/29022728/stereo-viewing-modulates-three-dimensional-shape-processing-during-object-recognition-a-high-density-erp-study
#14
Zoe J Oliver, Filipe Cristino, Mark V Roberts, Alan J Pegna, E Charles Leek
The role of stereo disparity in the recognition of 3-dimensional (3D) object shape remains an unresolved issue for theoretical models of the human visual system. We examined this issue using high-density (128 channel) recordings of event-related potentials (ERPs). A recognition memory task was used in which observers were trained to recognize a subset of complex, multipart, 3D novel objects under conditions of either (bi-) monocular or stereo viewing. In a subsequent test phase they discriminated previously trained targets from untrained distractor objects that shared either local parts, 3D spatial configuration, or neither dimension, across both previously seen and novel viewpoints...
October 12, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28954435/industrial-cooling-tower-disinfection-treatment-to-prevent-legionella-spp
#15
Matteo Iervolino, Benedetta Mancini, Sandra Cristino
The contamination of industrial cooling towers has been identified as one cause of legionellosis, but the real risk has been underestimated. Two different disinfection treatments were tested on Legionella colonization in an industrial Cooling Tower System (CTS). Environmental monitoring of Legionella , P. aeruginosa , and a heterotrophic plate count (HPC) at 36 °C was performed from June to October 2016. The disinfection procedures adopted were based on hydrogen peroxide (H₂O₂) and silver salts (Ag⁺), in addition to an anti-algal treatment, then using hyperclorination as a shock, and then continuous treatment by sodium hypochlorite (NaClO)...
September 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28840618/the-beneficial-effect-of-anthocyanidin-rich-vitis-vinifera-l-grape-skin-extract-on-metabolic-changes-induced-by-high-fat-diet-in-mice-involves-antiinflammatory-and-antioxidant-actions
#16
Gisele França da Costa, Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura
We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD). C57/BL6 mice were fed a standard diet (10% fat, control, and GSE groups) or an HFD (60% fat, high fat (HF), and HF + GSE) with or without GSE (200 mg/kg/day) for 12 weeks. GSE prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, and resistin; and the deregulation of leptin and adiponectin expression in adipose tissue...
October 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28820285/oligometastatic-cancer-stereotactic-ablative-radiotherapy-for-patients-affected-by-isolated-body-metastasis
#17
Andrea Lancia, Gianluca Ingrosso, Alessandra Carosi, Luana Di Murro, Emilia Giudice, Sara Cicchetti, Pasquale Morelli, Daniela di Cristino, Claudia Bruni, Alessandra Murgia, Alessandro Cancelli, Irene Turturici, Anjali Iadevaia, Elisabetta Ponti, Riccardo Santoni
BACKGROUND: To evaluate the outcome of patients affected by a single isolated body metastasis treated with stereotactic body radiotherapy (SBRT). MATERIAL AND METHODS: Seven-eight patients were treated with SBRT for isolated body metastasis. The most frequent primary tumor was prostate cancer (28.2%), followed by colorectal cancer (23.1%) and lung cancer (20.5%). Median age at diagnosis of oligometastatic disease was 70 years (range 47-88). Median Karnofsky Performance Status (KPS) was 90 (range 70-100)...
November 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28750816/techniques-for-the-cellular-and-subcellular-localization-of-endocannabinoid-receptors-and-enzymes-in-the-mammalian-brain
#18
Luigia Cristino, Roberta Imperatore, Vincenzo Di Marzo
This chapter attempts to piece together knowledge about new advanced microscopy techniques to study the neuroanatomical distribution of endocannabinoid receptors and enzymes at the level of cellular and subcellular structures and organelles in the brain. Techniques ranging from light to electron microscopy up to the new advanced LBM, PALM, and STORM super-resolution microscopy will be discussed in the context of their contribution to define the spatial distribution and organization of receptors and enzymes of the endocannabinoid system (ECS), and to better understand ECS brain functions...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28745525/balance-and-falls-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-a-prospective-study
#19
Cristino C Oliveira, Annemarie L Lee, Jennifer McGinley, Gary P Anderson, Ross A Clark, Michelle Thompson, Sandy Clarke, Tamara Baker, Louis B Irving, Linda Denehy
Individuals with chronic obstructive pulmonary disease (COPD) have demonstrated balance impairment and a higher fall incidence. However, these have not been investigated in acute exacerbations of the disease (ECOPD). This study evaluates balance in patients during an ECOPD compared to stable COPD and healthy controls, and examines the fall incidence rate after hospitalisation due to ECOPD compared to individuals with stable COPD. Balance performance of 26 hospitalised patients with ECOPD was compared to 26 community-dwelling participants with stable COPD and 25 matched healthy controls...
October 2017: COPD
https://www.readbyqxmd.com/read/28739056/supplementation-with-vitis-vinifera-l-skin-extract-improves-insulin-resistance-and-prevents-hepatic-lipid-accumulation-and-steatosis-in-high-fat-diet-fed-mice
#20
Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Ana Paula Machado da Rocha, Gisele França da Costa, Dayane Teixeira Ognibene, Roberto Soares de Moura, Angela Castro Resende
Nonalcoholic fatty liver disease is one of the most common complications of obesity. The Vitis vinifera L. grape skin extract (ACH09) is an important source of polyphenols, which are related to its antioxidant and antihyperglycemic activities. We hypothesized that ACH09 could also exert beneficial effects on metabolic disorders associated with obesity and evaluated ACH09's influence on high-fat (HF) diet-induced hepatic steatosis and insulin resistance in C57BL/6 mice. The animals were fed a standard diet (10% fat, control) or an HF diet (60% fat, HF) with or without ACH09 (200mg/[kg d]) for 12weeks...
July 2017: Nutrition Research
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