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Aid in dying

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https://www.readbyqxmd.com/read/28325745/aid-in-dying-laws-and-the-physician-s-duty-to-inform
#1
Mara Buchbinder
On 19 July 2016, three medical organisations filed a federal lawsuit against representatives from several Vermont agencies over the Patient Choice and Control at End of Life Act. The law is similar to aid-in-dying (AID) laws in four other US states, but the lawsuit hinges on a distinctive aspect of Vermont's law pertaining to patients' rights to information. The lawsuit raises questions about whether, and under what circumstances, there is an ethical obligation to inform terminally ill patients about AID as an end-of-life option...
March 21, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28325580/perinatal-death-investigations-what-is-current-practice
#2
REVIEW
J W Nijkamp, N J Sebire, K Bouman, F J Korteweg, J J H M Erwich, S J Gordijn
Perinatal death (PD) is a devastating obstetric complication. Determination of cause of death helps in understanding why and how it occurs, and it is an indispensable aid to parents wanting to understand why their baby died and to determine the recurrence risk and management in subsequent pregnancy. Consequently, a perinatal death requires adequate diagnostic investigation. An important first step in the analysis of PD is to identify the case circumstances, including relevant details regarding maternal history, obstetric history and current pregnancy (complications are evaluated and recorded)...
March 15, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28320172/neuropathological-findings-from-an-autopsied-case-showing-posterior-reversible-encephalopathy-syndrome-like-neuroradiological-findings-associated-with-premedication-including-tacrolimus-for-autologous-peripheral-blood-stem-cell-transplantation
#3
Yuichi Hayashi, Akio Kimura, Hiroshi Nakamura, Maya Mimuro, Yasushi Iwasaki, Akira Hara, Mari Yoshida, Takashi Inuzuka
Posterior reversible encephalopathy syndrome (PRES) is diagnosed based on neuroradiological findings. Typically, PRES is reversible and presents with a good outcome; however, fatal outcomes have been reported. We report an autopsied case showing PRES-like neuroradiological findings associated with premedication including tacrolimus for autologous peripheral blood stem cell transplantation in a 28-year-old woman with a 2-year history of acute myeloid sarcoma/acute myeloid leukemia. Neurological examination revealed disturbed consciousness, muscle weakness in all extremities, and bilaterally diminished tendon reflexes...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28318156/-comparative-evaluation-of-the-marginal-accuracy-of-single-crowns-fabricated-computer-using-aided-design-computer-aided-manufacturing-methods-self-curing-resin-and-luxatemp
#4
Yuan Jianming, Tang Ying, Pan Feng, Xu Weixing
OBJECTIVE: This study aims to compare the marginal accuracy of single crowns fabricated using self-curing resin, Luxatemp, and computer aided design/computer aided manufacturing (CAD/CAM) methods in clinical application. METHODS: A total of 30 working dies, which were obtained from 30 clinical teeth prepared with full crown as standard, were created and made into 30 self-curing resin, Luxatemp, and CAD/CAM single crowns. The restorations were seated on the working dies, and stereomicroscope was used to observe and measure the thickness of reference points...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28317630/oliver-cromwell-s-fatal-ague
#5
EDITORIAL
Sanjay Saint, Thomas Cogswell, Eliot Siegel, Philip A Mackowiak
Although many people recognize Oliver Cromwell by name, few know more than the barest details of his life or his legacy, and fewer still of the "ague" that ended his brief reign as Lord Protector of the Commonwealth of England, Scotland and Ireland and one of Britain׳s greatest generals. He died suddenly at age 59. Cromwell was the "terror of Europe" during that period. His physicians diagnosed his fatal disorder as "bastard tertian ague." A contemporary analysis of his clinical record, including one with the aid of the U...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28301337/improving-estimates-of-children-living-with-hiv-from-the-spectrum-aids-impact-model
#6
Mary Mahy, Martina Penazzato, Andrea Ciaranello, Lynne Mofenson, Constantin T Yianoutsos, Mary-Ann Davies, John Stover
OBJECTIVE: Estimated numbers of children living with HIV determine programmatic and treatment needs. We explain the changes made to the UNAIDS estimates between 2015 and 2016, and describe the challenges around these estimates. METHODS: Estimates of children newly infected, living with HIV, and dying of AIDS are developed by country teams using Spectrum software. Spectrum files are available for 160 countries, which represent 98% of the global population. In 2016, the methods were updated to reflect the latest evidence on mother-to-child HIV transmission and improved assumptions on the age children initiate antiretroviral therapy...
April 2017: AIDS
https://www.readbyqxmd.com/read/28296798/all-cause-mortality-in-hiv-positive-adults-starting-combination-antiretroviral-therapy-correcting-for-loss-to-follow-up
#7
Nanina Anderegg, Leigh F Johnson, Elizabeth Zaniewski, Keri N Althoff, Eric Balestre, Matthew Law, Denis Nash, Bryan E Shepherd, Constantin T Yiannoutsos, Matthias Egger
OBJECTIVE: To estimate mortality in HIV-positive patients starting combination antiretroviral therapy (ART) and to discuss different approaches to calculating correction factors to account for loss to follow-up. METHODS: A total of 222 096 adult HIV-positive patients who started ART 2009-2014 in clinics participating in the International epidemiology Databases to Evaluate AIDS collaboration in 43 countries in sub-Saharan Africa, Asia Pacific, Latin America, and North America were included...
April 2017: AIDS
https://www.readbyqxmd.com/read/28291064/scrotal-melanoma-a-systematic-review-of-presentation-treatment-and-outcomes
#8
Joseph Zikry, Lance W Chapman, Dorota Z Korta, Janellen Smith
BACKGROUND: Primary male genital melanomas are rare. Of these, scrotal melanoma is the least common, and is unfortunately often detected late in the disease course. OBJECTIVE: To assess the clinical presentation, treatment modalities, and outcome of scrotal melanoma to aid clinician management. METHODS: Systematic literature review of PubMed, yielding 23 cases, of which 20 met the inclusion criteria. RESULTS: Although previously thought to have the best outcome of genitourinary melanomas, scrotal melanomas are associated with high mortality and late presentation...
March 13, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28290773/the-hiv-care-cascade-and-sub-analysis-of-those-linked-to-but-not-retained-in-care-the-experience-from-a-tertiary-hiv-referral-service-in-dublin-ireland
#9
P McGettrick, B Ghavami-Kia, W Tinago, A Macken, J O'Halloran, J S Lambert, G Sheehan, P W G Mallon
BACKGROUND: The HIV Care Cascade model can be used to measure how clinical services align with United Nations' (UN) HIV treatment targets. Previous models have highlighted sequential losses at each step of the Cascade with a significant proportion being not retained in care (NRIC). OBJECTIVE: We aimed to assess the feasibility of meeting the UN targets and assess factors associated with, and calculate the true proportion of those, NRIC. METHODS: All people living with HIV who were linked to our service, one of three specialist HIV care providers in Dublin Ireland, from its establishment in 1993 to 1 December 2014, were included in the cohort and were categorized as linked to care, retained in care (RIC), on antiretroviral therapy (on ART), virally suppressed (HIV RNA <40copies/ml), and NRIC...
March 14, 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/28287498/risk-factors-for-mortality-among-adult-hiv-aids-patients-following-antiretroviral-therapy-in-southwestern-ethiopia-an-assessment-through-survival-models
#10
Dinberu Seyoum, Jean-Marie Degryse, Yehenew Getachew Kifle, Ayele Taye, Mulualem Tadesse, Belay Birlie, Akalu Banbeta, Angel Rosas-Aguirre, Luc Duchateau, Niko Speybroeck
Introduction: Efforts have been made to reduce HIV/AIDS-related mortality by delivering antiretroviral therapy (ART) treatment. However, HIV patients in resource-poor settings are still dying, even if they are on ART treatment. This study aimed to explore the factors associated with HIV/AIDS-related mortality in Southwestern Ethiopia. Method: A non-concurrent retrospective cohort study which collected data from the clinical records of adult HIV/AIDS patients, who initiated ART treatment and were followed between January 2006 and December 2010, was conducted, to explore the factors associated with HIV/AIDS-related mortality at Jimma University Specialized Hospital (JUSH)...
March 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28282677/-physician-assisted-suicide-survey-on-%C3%A2-217-stgb-in-germany
#11
Julia Zenz, Ruth Rissing-van Saan, Michael Zenz
Background In late 2015, Germany passed a law (§ 217 StGB) prohibiting persons from aiding others in committing suicide on a regular, repetitive basis. Despite intensive societal debate and surveys about assisted dying, the present study was the first to examine attitudes towards the new legal regulation among professionals. Methods In early 2016, all participants of a congress on palliative care received a one-page anonymous questionnaire to complete until the end of the conference. The questionnaire consisted of questions regarding assisted suicide and the new law...
March 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28281216/a-hypoperfusion-context-may-aid-to-interpret-hyperlactatemia-in-sepsis-3-septic-shock-patients-a-proof-of-concept-study
#12
Leyla Alegría, Magdalena Vera, Jorge Dreyse, Ricardo Castro, David Carpio, Carolina Henriquez, Daniela Gajardo, Sebastian Bravo, Felipe Araneda, Eduardo Kattan, Pedro Torres, Gustavo Ospina-Tascón, Jean-Louis Teboul, Jan Bakker, Glenn Hernández
BACKGROUND: Persistent hyperlactatemia is particularly difficult to interpret in septic shock. Besides hypoperfusion, adrenergic-driven lactate production and impaired lactate clearance are important contributors. However, clinical recognition of different sources of hyperlactatemia is unfortunately not a common practice and patients are treated with the same strategy despite the risk of over-resuscitation in some. Indeed, pursuing additional resuscitation in non-hypoperfusion-related cases might lead to the toxicity of fluid overload and vasoactive drugs...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28274045/an-assessment-of-curve-of-spee-in-healthy-human-permanent-dentitions-a-cross-sectional-analytical-study-in-a-group-of-young-indian-population
#13
Sushma Krishnamurthy, Rajendra B Hallikerimath, Praveenkumar S Mandroli
INTRODUCTION: An awareness of the standard value of the maxillary and the mandibular curves of Spee may aid the clinician in developing occlusion in the sagittal plane and would be useful when providing prosthetic rehabilitation for patients with occlusal derangement. AIM: To assess and compare the radius and depth of curve of Spee in maxillary and mandibular arches in men and women, in a group of young Indian population. MATERIALS AND METHODS: The study cohort consisted of 25 men and 25 women between 19 to 24 years...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28266696/mortality-disparities-among-hiv-men-and-women-in-puerto-rico-data-from-the-hiv-aids-surveillance-system-2003-2014
#14
Vivian Colón-López, Sandra Miranda-De León, Mark Machin-Rivera, Edna Marrero, Yadira Rolón-Colón, Ileska M Valencia-Torres, Erick Suárez
OBJECTIVE: Describe the trend of the indirect standardized death rate of HIV for different modes of HIV transmission from 2003 to 2014 in Puerto Rico. Estimate the magnitude of the association between mode of HIV transmission and mortality at different time periods in Puerto Rico. METHODS: ISDRs by sex and mode of transmission were computed using data from the PR National HIV/AIDS Surveillance System (2003-2014). Poisson models were used to assess the annual percent change of the ISDRs and RRs by sex...
March 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28249598/the-prognostic-utility-of-the-transcription-factor-srf-in-docetaxel-resistant-prostate-cancer-in-vitro-discovery-and-in-vivo-validation
#15
D J Lundon, A Boland, M Prencipe, G Hurley, A O'Neill, E Kay, S T Aherne, P Doolan, S F Madden, M Clynes, C Morrissey, J M Fitzpatrick, R W Watson
BACKGROUND: Docetaxel based therapy is one of the first line chemotherapeutic agents for the treatment of metastatic castrate-resistant prostate cancer. However, one of the major obstacles in the treatment of these patients is docetaxel-resistance. Defining the mechanisms of resistance so as to inform subsequent treatment options and combinations represents a challenge for clinicians and scientists. Previous work by our group has shown complex changes in pro and anti-apoptotic proteins in the development of resistance to docetaxel...
March 1, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28246153/medical-aid-in-dying-what-matters-most
#16
Peter Tanuseputro
No abstract text is available yet for this article.
January 23, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28245682/-hypothermia-treatment-in-asphyxiated-neonates-a-single-center-experience-in-hungary
#17
Kata Kovács, Enikő Szakmár, Ünőke Méder, Márton Kolossváry, Zsolt Bagyura, Lilla Lamboy, Zsuzsanna Élő, Attila Szabó, Miklós Szabó, Ágnes Jermendy
INTRODUCTION AND AIM: We aimed to analyze patient characteristics of term neonates with hypoxic-ischemic encephalopathy treated with hypothermia at the 3rd level Neonatal Intensive Care Unit of the 1st Department of Pediatrics, Semmelweis University. METHOD: We conducted a retrospective cohort analysis between 2013-2015, including 97 asphyxiated neonates with HIE who received hypothermia treatment, using our in-house developed novel registry database. RESULTS: 59...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28243819/hiv-and-aids-in-irish-theatre-queer-masculinities-punishment-and-post-aids-culture
#18
Cormac O'Brien
This essay provides a critical survey of key Irish theatre productions that present queer men with HIV or AIDS as a central theme while also seeking to situate several of these productions within the controversial discourse of 'post-AIDS' as it plays out in Irish cultural and social discourses. Through this survey, this essay finds and critically elaborates how a discourse of AIDS as punishment is a common denominator in all of these plays; whether that be as a central metaphor in the drama or conversely as a trope that theatre makers seek to disrupt...
February 27, 2017: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28241797/changes-in-mortality-rates-and-causes-of-death-in-a-population-based-cohort-of-persons-living-with-and-without-hiv-from-1996-to-2012
#19
Oghenowede Eyawo, Conrado Franco-Villalobos, Mark W Hull, Adriana Nohpal, Hasina Samji, Paul Sereda, Viviane D Lima, Jeannie Shoveller, David Moore, Julio S G Montaner, Robert S Hogg
BACKGROUND: Non-HIV/AIDS-related diseases are gaining prominence as important causes of morbidity and mortality among people living with HIV. The purpose of this study was to characterize and compare changes over time in mortality rates and causes of death among a population-based cohort of persons living with and without HIV in British Columbia (BC), Canada. METHODS: We analysed data from the Comparative Outcomes And Service Utilization Trends (COAST) study; a retrospective population-based study created via linkage between the BC Centre for Excellence in HIV/AIDS and Population Data BC, and containing data for HIV-infected individuals and the general population of BC, respectively...
February 27, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28240500/sharp-force-fatalities-at-the-pretoria-medico-legal-laboratory-2012-2013
#20
L Mitton, L du Toit-Prinsloo
BACKGROUND: South Africa's crude death rate was recorded as the highest in the world in 2014. In 2013, 47 murders occurred daily nationwide, and it was confirmed that sharp force fatalities were frequent events. The aim of our study was to review the fatalities of persons admitted to the Pretoria Medico-Legal Laboratory over a two-year period. Understanding the magnitude of the problem, identifying the most commonly injured area and the mechanism of death in cases where the patient died in hospital could aid in the clinical management of some of these cases in order to reduce mortality...
June 2016: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
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