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https://www.readbyqxmd.com/read/28633458/causes-of-death-and-mortality-trends-of-all-individuals-reported-with-hiv-aids-in-israel-1985-2010
#1
Zohar Mor, Rivka Sheffer, Daniel Chemtob
Background: Highly active antiretroviral therapy (HAART) has changed life-expectancy and mortality trends among people living with HIV/AIDS (PLWHA) since 1996. This retrospective cohort study aimed to assess the mortality epidemiology of PLWHA in Israel and analyze the causes of death. Methods: This cohort study included all adult Israeli-citizens PLWHA between 1985 and 2010 and crossed matched with the Civil Registry to identify those who died. Death certificates were classified into AIDS or non-AIDS deaths related-causes...
June 17, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28624976/are-concerns-about-irremediableness-vulnerability-or-competence-sufficient-to-justify-excluding-all-psychiatric-patients-from-medical-aid-in-dying
#2
William Rooney, Udo Schuklenk, Suzanne van de Vathorst
Some jurisdictions that have decriminalized assisted dying (like Canada) exclude psychiatric patients on the grounds that their condition cannot be determined to be irremediable, that they are vulnerable and in need of protection, or that they cannot be determined to be competent. We review each of these claims and find that none have been sufficiently well-supported to justify the differential treatment psychiatric patients experience with respect to assisted dying. We find bans on psychiatric patients' access to this service amount to arbitrary discrimination...
June 17, 2017: Health Care Analysis: HCA: Journal of Health Philosophy and Policy
https://www.readbyqxmd.com/read/28619532/major-physical-health-conditions-and-risk-of-suicide
#3
Brian K Ahmedani, Edward L Peterson, Yong Hu, Rebecca C Rossom, Frances Lynch, Christine Y Lu, Beth E Waitzfelder, Ashli A Owen-Smith, Samuel Hubley, Deepak Prabhakar, L Keoki Williams, Nicole Zeld, Elizabeth Mutter, Arne Beck, Dennis Tolsma, Gregory E Simon
INTRODUCTION: Most individuals make healthcare visits before suicide, but many do not have a diagnosed mental health condition. This study seeks to investigate suicide risk among patients with a range of physical health conditions in a U.S. general population sample and whether risk persists after adjustment for mental health and substance use diagnoses. METHODS: This study included 2,674 individuals who died by suicide between 2000 and 2013 along with 267,400 controls matched on year and location in a case-control study conducted in 2016 across eight Mental Health Research Network healthcare systems...
June 7, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28614446/-factors-associated-with-tb-hiv-coinfection-evidence-from-notification-data-in-the-state-of-amazonas-brazil-2001-2012
#4
Evela da Silva Magno, Valeria Saraceni, Alexandra Brito de Souza, Regma da Silva Magno, Maria das Graças Gomes Saraiva, Samira Bührer-Sékula
Tuberculosis (TB) in persons living with HIV (PLHIV) is the leading infectious cause of AIDS-related death. The aim of this study was to estimate the prevalence of TB/HIV coinfection, evaluate notification of the two diseases over time by probabilistic database linkage, and identify factors associated with AIDS and TB notifications. Prevalence of TB/HIV coinfection was 7.7%. The group of PLHIV with subsequent TB diagnosis was the most representative, despite available preventive measures. Underreporting of TB among AIDS cases was 35%, and 19...
June 12, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28613918/new-sepsis-definition-sepsis-3-and-community-acquired-pneumonia-mortality-a-validation-and-clinical-decision-making-study
#5
Otavio T Ranzani, Elena Prina, Rosario Menéndez, Adrian Ceccato, Catia Cilloniz, Raul Méndez, Albert Gabarrus, Enric Barbeta, Gianluigi Li Bassi, Miquel Ferrer, Antoni Torres
RATIONALE: Sepsis-3 Task Force updated the clinical criteria for sepsis, excluding the need for systemic inflammatory response syndrome (SIRS) criteria. The clinical implications of the proposed flowchart including the quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA) and SOFA scores are unknown. OBJECTIVE: To perform a clinical decision-making analysis of Sepsis-3 in patients with community-acquired pneumonia (CAP). METHODS: Cohort study including adult patients with CAP from two Spanish university-hospitals...
June 14, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28611289/next-generation-sequencing-and-molecular-imaging-identify-egfr-mutation-and-amplification-in-a-glioblastoma-multiforme-patient-treated-with-an-egfr-inhibitor-a-case-report
#6
Ke Zhou, Hui Yao, Xuewen Zhang, Jiangang Liu, Zhenyu Qi, Xueshun Xie, Xiaoting Xu, Youxin Zhou, Zhengquan Yu, Zhong Wang, Yanjun Che, Yulun Huang
Epidermal growth factor receptor (EGFR) mutations and amplifications are frequently reported in glioblastoma multiforme (GBM) patients. In this case report, we utilize next-generation sequencing (NGS) and EGFR molecular imaging to investigate intratumoral heterogeneity in a male patient presenting with GBM. Further, we describe the patient's clinical course as well as outcomes of targeted EGFR therapy with erlotinib, an EGFR tyrosine kinase inhibitor (TKI). NGS demonstrated the presence of an EGFR mutation and amplification in our patient...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28608435/cad-cam-fabricated-ceramic-implant-supported-single-crowns-made-from-lithium-disilicate-final-results-of-a-5-year-prospective-cohort-study
#7
Benedikt Christopher Spies, Stefano Pieralli, Kirstin Vach, Ralf-Joachim Kohal
BACKGROUND: All-ceramic bilayer systems suffer from technique-sensitivity, resulting in increased technical complication rates. This might be overcome by monolithic reconstructions, facilitating digital workflows. PURPOSE: To evaluate the clinical and patient-reported outcome of CAD/CAM-fabricated implant-supported single crowns (ISCs) made of lithium disilicate (LS2 ) cemented on ceramic implants 5 years after implant installation. MATERIALS AND METHODS: Twenty-four patients were included in the study...
June 13, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28598872/many-faces-of-neurosarcoidosis-from-chronic-meningitis-to-myelopathy
#8
Daan Fritz, Mareye Voortman, Diederik van de Beek, Marjolein Drent, Matthijs C Brouwer
PURPOSE OF REVIEW: Neurosarcoidosis occurs in 5% of patients with sarcoidosis and can be difficult to diagnose. In this review we discuss the most recent advances in our understanding of the disease, describing clinical characteristics, diagnostic process, treatment, and prognosis. RECENT FINDINGS: Clinical presentation is heterogeneous with most patients presenting with cranial nerve palsy, headache, or sensory abnormalities. Patients are classified according to probability of the diagnosis with the Zajicek criteria...
June 8, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28598196/derivation-and-validation-of-a-prognostic-model-to-predict-six-month-mortality-in-an-intensive-care-unit-population
#9
Sarah Hadique, Stacey Culp, Rahul G Sangani, Kyle D Chapman, Saad Khan, John E Parker, Alvin H Moss
RATIONALE: Identification of terminally ill patients in the intensive care unit (ICU) would facilitate decision making and timely palliative care. OBJECTIVE: To develop and validate a patient-specific integrated prognostic model to predict six-month mortality in medical ICU patients. METHODS: A longitudinal prospective cohort study of temporally split samples of 1049 consecutive Medical ICU patients in a tertiary care hospital was performed...
June 9, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28594295/long-term-outcomes-of-second-line-antiretroviral-treatment-in-an-adult-and-adolescent-cohort-in-myanmar
#10
Nang Thu Thu Kyaw, Ajay M V Kumar, Myo Minn Oo, Htun Nyunt Oo, Khine Wut Yee Kyaw, Soe Thiha, Thet Ko Aung, Than Win, Yin Yin Mon, Anthony D Harries
BACKGROUND: Myanmar has a high burden of Human Immunodeficiency Virus (HIV) and second-line antiretroviral treatment (ART) has been available since 2008 in the public health sector. However, there have been no published data about the outcomes of such patients until now. OBJECTIVE: To assess the treatment and programmatic outcomes and factors associated with unfavorable outcomes (treatment failure, death and loss to follow-up from care) among people living with HIV (aged ≥ 10 years) receiving protease inhibitor-based second-line ART under the Integrated HIV Care Program in Myanmar between October 2008 and June 2015...
2017: Global Health Action
https://www.readbyqxmd.com/read/28592482/aid-in-dying-the-role-of-the-critical-care-nurse
#11
Judy E Davidson, Forrest G Hooper
No abstract text is available yet for this article.
2017: AACN Advanced Critical Care
https://www.readbyqxmd.com/read/28590345/two-cases-of-epithelioid-trophoblastic-tumors-in-postmenopausal-women
#12
Adriano Rodríguez-Trujillo, María José Martínez-Serrano, Adela Saco, Aureli Torné
OBJECTIVE: Epithelioid trophoblastic tumor is a rare gestational trophoblastic neoplasm usually presenting in women of reproductive age, with a history of a prior gestational event. Its presentation in postmenopausal women is extremely rare. Immunohistochemical staining is a helpful aid to distinguish epithelioid trophoblastic tumor from other gestational trophoblastic neoplasms. Correct diagnosis is crucial for clinical management that can vary according to the type of gestational trophoblastic neoplasm...
June 5, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28586259/implementation-of-advance-care-planning-in-oncology-a-review-of-the-literature
#13
Christine M Bestvina, Blase N Polite
Advance care planning (ACP) should be initiated early and be readdressed often for patients with cancer. This directive is expressed in the Institute of Medicine's report, "Dying in America," and is a component of several quality metrics, including ASCO's Quality Oncology Practice Initiative and the Centers for Medicare & Medicaid Services Oncology Care Model. Although simple in concept, implementation in practice is challenging. A variety of patient education tools exist in several different forms, including pamphlets, guidebooks, and question prompt lists, with the strongest data supporting the use of video decision aids that depict cardiopulmonary resuscitation...
June 6, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28573513/knee-joint-preservation-surgery-in-osteosarcoma-using-tumour-bearing-bone-treated-with-liquid-nitrogen
#14
Takashi Higuchi, Norio Yamamoto, Hideji Nishida, Katsuhiro Hayashi, Akihiko Takeuchi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Inatani, Shingo Shimozaki, Takashi Kato, Yu Aoki, Kensaku Abe, Yuta Taniguchi, Hiroyuki Tsuchiya
PURPOSE: To preserve the joint structure in order to maintain good limb function in patients with osteosarcoma, we perform epiphyseal or metaphyseal osteotomy and reconstruction using frozen autografts that contain a tumour treated with liquid nitrogen. There are two methods of using liquid nitrogen-treated autografts: the free-freezing method and the pedicle-freezing method. The purpose of this study was to evaluate the results of intentional joint-preserving reconstruction using the free-freezing method and the pedicle-freezing method in patients with osteosarcoma...
June 1, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28571514/obstetric-ultrasound-aids-prompt-referral-of-gestational-trophoblastic-disease-in-marginalized-populations-on-the-thailand-myanmar-border
#15
Kathryn McGregor, Aung Myat Min, Noaeni Karunkonkowit, Suporn Keereechareon, Mary Ellen Tyrosvoutis, Nay Win Tun, Marcus J Rijken, Gabie Hoogenboom, Machteld Boel, Kesinee Chotivanich, François Nosten, Rose McGready
BACKGROUND: The use of obstetric ultrasound in the diagnosis of gestational trophoblastic disease (GTD) in high-income settings is well established, leading to prompt management and high survival rates. Evidence from low-income settings suggests ultrasound is essential in identifying complicated pregnancies, but with limited studies reviewing specific conditions including GTD. OBJECTIVE: The aim of this study is to review the role of ultrasound in diagnosis and management of GTD in a marginalized population on the Thailand-Myanmar border...
2017: Global Health Action
https://www.readbyqxmd.com/read/28569447/marginal-accuracy-and-internal-fit-of-dental-copings-fabricated-by-modern-additive-and-subtractive-digital-technologies
#16
Neha Nelson, Jyothi K S, Kiran Sunny
The margins of copings for crowns and retainers of fixed partial dentures affect the progress of microleakage and dental caries. Failures occur due to altered fit which is also influenced by the method of fabrication. An in-vitro study was conducted to determine among the cast base metal, copy milled zirconia, computer aided designing computer aided machining/manufacturing zirconia and direct metal laser sintered copings which showed best marginal accuracy and internal fit. Forty extracted maxillary premolars were mounted on an acrylic model and reduced occlusally using a milling machine up to a final tooth height of 4 mm from the cementoenamel junction...
March 2017: European Journal of Prosthodontics and Restorative Dentistry
https://www.readbyqxmd.com/read/28565963/genomic-instability-induced-in-distant-progeny-of-bystander-cells-depends-on-the-connexins-expressed-in-the-irradiated-cells
#17
Sonia M de Toledo, Manuela Buonanno, Andrew L Harris, Edouard I Azzam
PURPOSE: To examine the time window during which intercellular signaling though gap junctions mediates non-targeted (bystander) effects induced by moderate doses of ionizing radiation; and to investigate the impact of gap junction communication on genomic instability in distant progeny of bystander cells. MATERIALS AND METHODS: A layered cell culture system was developed to investigate the propagation of harmful effects from irradiated normal or tumor cells that express specific connexins to contiguous bystander normal human fibroblasts...
June 15, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28558689/mortality-in-patients-with-hiv-1-and-tuberculosis-co-infection-in-rio-de-janeiro-brazil-associated-factors-and-causes-of-death
#18
Rodrigo Otavio da Silva Escada, Luciane Velasque, Sayonara Rocha Ribeiro, Sandra Wagner Cardoso, Luana Monteiro Spindola Marins, Eduarda Grinsztejn, Maria Cristina da Silva Lourenço, Beatriz Grinsztejn, Valdiléa Gonçalves Veloso
BACKGROUND: Tuberculosis is the most frequent opportunistic infection and the leading cause of death among persons living with HIV in several low and middle-income countries. Mortality rates during tuberculosis treatment and death causes among HIV-1/TB co-infected patients may differ based on the immunosuppression severity, timing of diagnosis and prompt initiation of tuberculosis and antiretroviral therapy. METHODS: This was a retrospective observational study conducted in the clinical cohort of patients with HIV-1/Aids of the National Institute of Infectious Diseases Evandro Chagas, Rio de Janeiro, Brazil...
May 30, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28555483/point-process-methods-in-epidemiology-application-to-the-analysis-of-human-immunodeficiency-virus-acquired-immunodeficiency-syndrome-mortality-in-urban-areas
#19
Jose Antonio Quesada, Inmaculada Melchor, Andreu Nolasco
The analysis of spatio-temporal patterns of disease or death in urban areas has been developed mainly from the ecological studies approach. These designs may have some limitations like the ecological fallacy and instability with few cases. The objective of this study was to apply the point process methodology, as a complement to that of aggregated data, to study HIV/AIDS mortality in men in the city of Alicante (Spain). A case-control study in residents in the city during the period 2004-2011 was designed. Cases were men who died from HIV/AIDS and controls represented the general population, matched by age to cases...
May 26, 2017: Geospatial Health
https://www.readbyqxmd.com/read/28555169/strongyloides-colitis-as-a-harmful-mimicker-of-inflammatory-bowel-disease
#20
Julio Poveda, Farah El-Sharkawy, Leopoldo R Arosemena, Monica T Garcia-Buitrago, Claudia P Rojas
Autoinfection caused by Strongyloides stercoralis frequently becomes a life-long disease unless it is effectively treated. There is overlapping histomorphology between Strongyloides colitis and inflammatory bowel disease; a low index of suspicion can lead to misdiagnosis and fatal consequences. We present a case of Strongyloides colitis mimicking the clinical and pathologic features of inflammatory bowel disease. A 64-year-old female presented to the emergency department with a four-day history of abdominal pain, diarrhea, and hematochezia...
2017: Case Reports in Pathology
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