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https://www.readbyqxmd.com/read/29332028/possible-erythrocyte-contributions-to-and-exacerbation-of-the-post-thrombolytic-no-reflow-phenomenon
#1
Shang-Jen Yu, James P Buerck, Edgar A O'Rear, Thomas L Whitsett
BACKGROUND: Reperfusion injury often occurs with therapeutic intervention addressing the arterial occlusions causing acute myocardial infarction and stroke. The no-reflow phenomenon has been ascribed to leukocyte plugging and blood vessel constriction in the microcirculation. OBJECTIVE: To assess possible red cell contributions to post thrombolytic no-reflow phenomenon. METHODS: Blood clots were formed by recalcifying 1 ml of citrated fresh human venous blood and then lysed by adding 1,000 units of streptokinase (SK) at several intervals within 1 hour...
January 11, 2018: Biorheology
https://www.readbyqxmd.com/read/29329448/the-prevalence-and-management-of-dehydration-amongst-neonatal-admissions-to-general-paediatric-wards-in-kenya-a-clinical-audit
#2
Samuel Akech, Beatrice Rotich, Mercy Chepkirui, Philip Ayieko, Grace Irimu, Mike English
An audit of randomly selected case records of 810 patients admitted to 13 hospitals between December 2015 and November 2016 was done. Prevalence of dehydration was 19.7% (2293 of 11 636) [95% CI: 17.1-22.6%], range across hospitals was 9.4% to 27.0%. Most cases with dehydration were clinically diagnosed (82 of 153; 53.6%), followed by excessive weight loss (54 of 153; 35.3%) and abnormal urea/electrolytes/creatinine (23 of 153; 15.0%). Documentation of fluids prescribed was poor but, where data were available, Ringers lactate (30 of 153; 19...
January 9, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29329091/determination-of-imm-h004-and-its-active-glucuronide-metabolite-in-rat-plasma-and-ringer-s-solution-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry
#3
Jianwei Jiang, Ziqian Zhang, Xiaowen Zou, Rui Wang, Jie Bai, Shengyu Zhao, Xiaoqing Fan, Li Sheng, Yan Li
IMM-H004 is a novel neuroprotective agent and its glucuronide metabolite IMM-H004G has similar protective effects against cerebral ischemic injury in vivo and in vitro. A specific and sensitive ultra-performance liquid chromatography-tandem mass spectrometry method was established and validated for determination of IMM-H004 and IMM-H004G simultaneously in rat plasma and Ringer's solution. Plasma samples containing IMM-H004, IMM-H004G and internal standard propranolol were prepared by direct protein precipitation in a sample-to-solvent ratio of 1:2:6 (plasma: water: acetonitrile), whereas no protein precipitation was required for Ringer's solution samples...
December 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29326508/effect-of-ultraviolet-irradiation-on-the-osseointegration-of-a-titanium-alloy-with-bone
#4
Ashish Yadav, Ranjana Yadav, Aratee Gupta, Akash Baranwal, Atul Bhatnagar, Vakil Singh
Introduction: Attempt has been made to analyze the potential of titanium (Ti) alloy for osteointegration by the effect of surface photo functionalization in different aspects as follows: in Ringer's solution, in vitro cell growth, and in vivo study on rabbit. The present study was aimed to investigate the influence of ultraviolet (UV) light on surface topography, corrosion behavior, and bioactivity of indigenously manufactured samples of Ti alloy mini-implant. Materials and Methods: The study includes surface modification of Ti samples by UV treatment, corrosion testing of the specimens using Potentiostat (GAMRY System), qualitative examination of modified surface topography using scanning electron microscope, and cellular viability test on Ti alloy surface (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ASSAY)...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29324500/hydroxyethyl-starch-130-0-4-and-its-impact-on-perioperative-outcome-a-propensity-score-matched-controlled-observation-study
#5
Judith-Irina Pagel, Markus Rehm, Tobias Kammerer, Nikolai Hulde, Eike Speck, Josef Briegel, Falk Reinholz, Alexander Crispin, Klaus F Hofmann-Kiefer
BACKGROUND: Adverse effects of hydroxyethyl starches (HESs) have been verified in patients suffering from sepsis or kidney disease, but not in surgical patients at large. The investigation aimed to determine whether the use of HES 130/0.4 was associated with the incidence of acute postinterventional adverse events compared to Ringer's acetate alone in a perioperative setting. METHODS: This propensity score matched, controlled observational study was performed in a single-centre university hospital...
January 9, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29323409/in-vitro-comparison-of-two-neonatal-ecmo-circuits-using-a-roller-or-centrifugal-pump-with-three-different-in-line-hemoconcentrators-for-maintaining-hemodynamic-energy-delivery-to-the-patient
#6
Madison Force, Morgan Moroi, Shigang Wang, David A Palanzo, Allen R Kunselman, Akif Ündar
The objective of this study was to compare three different hemoconcentrators (Hemocor HPH 400, Mini, and Junior) with two different neonatal ECMO circuits using a roller or a centrifugal pump at different pseudo-patient pressures and flow rates in terms of hemodynamic properties. This evidence-based research is necessary to optimize the ECMO circuitry for neonates. The circuits used a 300-mL soft-shell reservoir as a pseudo-patient approximating the blood volume of a 3 kg neonate, two blood pumps, and a Quadrox-iD Pediatric oxygenator with three different in-line hemoconcentrators (Hemocor HPH 400, Mini, and Junior)...
January 11, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29319936/submucosal-gland-mucus-strand-velocity-is-decreased-in-chronic-rhinosinusitis
#7
Kiranya E Tipirneni, Shaoyan Zhang, Do-Yeon Cho, Jessica Grayson, Daniel F Skinner, Calvin Mackey, Lindsay Moore, Denzel Cole, Catherine G Banks, Bradford A Woodworth
BACKGROUND: Chronic rhinosinusitis (CRS) may be initiated by innately impaired host defense mechanisms that predispose the upper airways to infection. Recent evidence suggests tethering of submucosal gland mucus strands represents an inciting event within cystic fibrosis (CF) airways, occurring prior to onset of chronic infection. Submucosal gland hypertrophy and defective mucociliary clearance (MCC) are present in actively inflamed sinuses, but mucus strand velocity may also be affected as a secondary event, further contributing to chronic disease...
January 10, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29308615/alginate-microcapsules-as-nutrient-suppliers-an-in-vitro-study
#8
Ahad Khoshzaban, Peyman Keyhanvar, Elham Delrish, Farhood Najafi, Saeed Heidari Keshel, Ikuya Watanabe, Alireza Valanezhad, Tahereh Jafarzadeh Kashi
OBJECTIVES: Alginate, known as a group of anionic polysaccharides extracted from seaweeds, has attracted the attention of researchers because of its biocompatibility and degradability properties. Alginate has shown beneficial effects on wound healing as it has similar function as extracellular matrix. Alginate microcapsules (AM) that are used in tissue engineering as well as Dulbecco's modified Eagle's medium (DMEM) contain nutrients required for cell viability. The purpose of this research was introducing AM in medium and nutrient reagent cells and making a comparison with control group cells that have been normally cultured in long term...
April 2018: Cell Journal
https://www.readbyqxmd.com/read/29299592/chemoprevention-of-basal-and-squamous-cell-carcinoma-with-a-single-course-of-fluorouracil-5-cream-a-randomized-clinical-trial
#9
Martin A Weinstock, Soe Soe Thwin, Julia A Siegel, Kimberly Marcolivio, Alexander D Means, Nicholas F Leader, Fiona M Shaw, Daniel Hogan, David Eilers, Susan M Swetter, Suephy C Chen, Sharon E Jacob, Erin M Warshaw, George P Stricklin, Robert P Dellavalle, Navjeet Sidhu-Malik, Nellie Konnikov, Victoria P Werth, Jonette E Keri, Leslie Robinson-Bostom, Robert J Ringer, Robert A Lew, Ryan Ferguson, John J DiGiovanna, Grant D Huang
Importance: Keratinocyte carcinoma (ie, cutaneous basal and squamous cell carcinoma) is the most common cancer in the United States. Objective: To determine whether topical fluorouracil could prevent surgically treated keratinocyte carcinoma. Design, Setting, and Participants: The Veterans Affairs Keratinocyte Carcinoma Chemoprevention Trial was a randomized, double-blind, placebo-controlled trial of topical fluorouracil for chemoprevention of keratinocyte carcinoma...
January 3, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29288775/randomised-double-blind-controlled-clinical-trial-on-the-antiseptic-efficacy-by-reduction-of-cfu-with-polihexanide-0-04-on-acute-traumatic-wounds
#10
Barbara Payne, Hans-Peter Simmen, Esther Csuka, Matthias Hintzpeter, Steffen Pahl, Florian H H Brill
Prevention of wound infections is a challenge in clinical practice. The aim of this study was to assess the efficacy of polihexanide 0.04 % on acute traumatic wounds. It was a randomised, double-blind, placebo-controlled prospective trial which included 61 patients. The polihexanide group showed a significant decrease in log10 CFU (p<0.001) after 60 min treatment in comparison to baseline CFU, whereas the Ringer's solution group did not show a significant change of CFU during 60 min treatment. Treatment of polihexanide 0...
December 27, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29282084/r-100-improves-pulmonary-function-and-systemic-fluid-balance-in-sheep-with-combined-smoke-inhalation-injury-and-pseudomonas-aeruginosa-sepsis
#11
Hiroshi Ito, Erik Malgerud, Sven Asmussen, Ernesto Lopez, Andrew L Salzman, Perenlei Enkhbaatar
BACKGROUND: Septic shock is a major cause of death in intensive care units around the world . The aim of the study was to investigate whether the novel drug R-100 (a superoxide degradation catalyst and nitric oxide donor) improves pulmonary function in a sheep model of septic shock caused by Pseudomonas aeruginosa and smoke inhalation. METHODS: Eleven female sheep were prepared surgically and randomly assigned to a treatment group (n = 5) or a control group (n = 6) after inhalation of cooled cotton smoke and airway instillation of live P...
December 28, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29260928/contribution-of-sonicate-fluid-cultures-and-broad-range-pcr-to-microbiological-diagnosis-in-vascular-graft-infections
#12
Barbara Kokosar Ulcar, Nikola Lakic, Samo Jeverica, Blaz Pecavar, Mateja Logar, Tjasa Kisek Cerar, Tatjana Lejko-Zupanc
BACKGROUND: Vascular graft infections (VGI) are associated with considerable morbidity and mortality, and antimicrobial treatment is an important adjunct to surgical treatment. While microbial aetiology of VGI is often difficult to determine, other techniques such as sonication of implanted material may be used to enhance the recovery of biofilm-associated organisms. METHODS: We performed a retrospective analysis of 22 consecutive patients treated for VGI at University Medical Centre Ljubljana from May 2011 through January 2015...
December 20, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29247720/voltage-gated-potassium-channels-and-nos-contribute-to-a-sustained-cutaneous-vasodilation-elicited-by-local-heating-in-an-interactive-manner-in-young-adults
#13
Naoto Fujii, Lyra Halili, Takeshi Nishiyasu, Glen P Kenny
Local skin heating to 42°C causes rapid increases in cutaneous perfusion (initial peak), followed by a brief nadir and subsequent sustained elevation (plateau). Several studies have demonstrated that nitric oxide synthase (NOS) largely contributes to the plateau response during local heating. In this study, we tested the hypothesis that voltage-gated potassium (Kv) channels contribute to the plateau of the cutaneous vasodilation during local heating through NOS-dependent mechanisms. Eleven young males (25±4years) participated in this study wherein cutaneous vascular conductance (CVC) was measured at four intradermal microdialysis sites that were continuously perfused with either 1) lactated Ringer (Control), 2) 10mM 4-aminopyridine (Kv channel blocker), 3) 10mM Nω-Nitro-L-arginine (NOS inhibitor), or 4) a combination of 4-aminopyridine and Nω-Nitro-L-arginine...
December 13, 2017: Microvascular Research
https://www.readbyqxmd.com/read/29242652/the-effect-of-intravenous-dextrose-administration-for-prevention-of-post-operative-nausea-and-vomiting-after-laparoscopic-cholecystectomy-a-double-blind-randomised-controlled-trial
#14
Abolfazl Firouzian, Alieh Zamani Kiasari, Gholamali Godazandeh, Afshin Gholipour Baradari, Abbas Alipour, Arman Taheri, Amir Emami Zeydi, Maryam Montazemi
Background and Aims: Post-operative nausea and vomiting (PONV) is a common and distressing complication after laparoscopic cholecystectomy (LC). The aim of this study was to evaluate the effect of intravenous (IV) dextrose administration for the prophylaxis of PONV after LC. Methods: In a double-blind, randomised controlled trial, a total of 150 female patients who were scheduled for elective LC were randomly assigned into two groups (A and B). Thirty minutes before induction of anaesthesia, patients received an infusion of 500 cc lactated Ringer's solution (Group A) and 5% dextrose in lactated Ringer's solution (Group B) and over a period of 30 min...
October 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29241017/older-adult-multitasking-performance-using-a-gaze-contingent-useful-field-of-view
#15
Nathan Ward, John G Gaspar, Mark B Neider, James Crowell, Ronald Carbonari, Hank Kaczmarski, Ryan V Ringer, Aaron P Johnson, Lester C Loschky, Arthur F Kramer
Objective We implemented a gaze-contingent useful field of view paradigm to examine older adult multitasking performance in a simulated driving environment. Background Multitasking refers to the ability to manage multiple simultaneous streams of information. Recent work suggests that multitasking declines with age, yet the mechanisms supporting these declines are still debated. One possible framework to better understand this phenomenon is the useful field of view, or the area in the visual field where information can be attended and processed...
December 1, 2017: Human Factors
https://www.readbyqxmd.com/read/29237204/aggressive-intravenous-hydration-with-lactated-ringer-s-solution-for-prevention-of-post-ercp-pancreatitis-a-prospective-randomized-multicenter-clinical-trial
#16
Chang-Hwan Park, Woo Hyun Paik, Eun Taek Park, Chan Sup Shim, Tae Yoon Lee, Changdon Kang, Myung Hwan Noh, Sun Youn Yi, Jong Kyun Lee, Jong Jin Hyun, Jun Kyu Lee
Background and study aims The present study aimed to determine the type of intravenous hydration that is best suited to reducing the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Patients and methods In a prospective randomized multicenter trial, average-to-high risk patients who underwent first-time ERCP were randomly assigned to three groups (1:1:1) who received: aggressive intravenous hydration (3 mL/kg/h during ERCP, a 20-mL/kg bolus and 3 mL/kg/h for 8 hours after ERCP) with either lactated Ringer's solution (LRS) or normal saline solution (NSS), or standard intravenous hydration with LRS (1...
December 13, 2017: Endoscopy
https://www.readbyqxmd.com/read/29226612/glutaraldehyde-cross-linking-increases-the-stability-of-lumbricus-terrestris-erythrocruorin
#17
Athul Rajesh, Devon Zimmerman, Kyle Spivack, Osheiza Abdulmalik, Jacob Elmer
Since donated red blood cells must be constantly refrigerated, they are not available in remote areas and battlefields. We have previously shown that the hemoglobin of the earthworm Lumbricus terrestris (LtEc) is an effective and safe substitute for donated blood that is stable enough to be stored for long periods at the relatively high temperatures that may be encountered in remote areas. The goal of this study was to increase the thermal stability of LtEc by covalently cross-linking LtEc with glutaraldehyde (gLtEc)...
December 11, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/29222031/evaluation-of-the-effect-of-mesotherapy-in-the-management-of-back-pain-in-police-working-dog
#18
João Ca Alves, Ana Mmp Dos Santos, Ângelo Dp Fernandes
OBJECTIVE: To evaluate the feasibility and effectiveness of mesotherapy in dogs compared with a positive control group. STUDY DESIGN: Experimental, randomized, blinded study. ANIMALS: Fifteen working police dogs with chronic back pain. METHODS: Animals were divided randomly into control (CG; n = 5) and treatment groups (TG; n = 10). A combination of 140 mg lidocaine, 15 mg dexamethasone and 20 mg thiocolchicoside was administered to group TG along with a 70-day course of a placebo, administered as if it was carprofen...
August 19, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29219398/threshold-and-jet-radius-joint-resummation-for-single-inclusive-jet-production
#19
Xiaohui Liu, Sven-Olaf Moch, Felix Ringer
We present the first threshold and jet radius jointly resummed cross section for single-inclusive hadronic jet production. We work at next-to-leading logarithmic accuracy and our framework allows for a systematic extension beyond the currently achieved precision. Long-standing numerical issues are overcome by performing the resummation directly in momentum space within soft collinear effective theory. We present the first numerical results for the LHC and observe an improved description of the available data...
November 24, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29212305/cancer-energy-metabolism-shutting-power-off-cancer-factory
#20
REVIEW
Soo-Youl Kim
In 1923, Dr. Warburg had observed that tumors acidified the Ringer solution when 13 mM glucose was added, which was identified as being due to lactate. When glucose is the only source of nutrient, it can serve for both biosynthesis and energy production. However, a series of studies revealed that the cancer cell consumes glucose for biosynthesis through fermentation, not for energy supply, under physiological conditions. Recently, a new observation was made that there is a metabolic symbiosis in which glycolytic and oxidative tumor cells mutually regulate their energy metabolism...
January 1, 2018: Biomolecules & Therapeutics
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