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https://www.readbyqxmd.com/read/28339927/characterizing-the-early-inflammatory-contribution-of-the-donor-kidney-following-reperfusion
#1
John P Stone, Muna Mohamud, Kavit Amin, William R Critchley, Rebecca J Edge, Marc J Clancy, Alexandra L Ball, James E Fildes
Background.: Donor kidneys contain a large reservoir of passenger leucocytes that contribute to acute rejection via direct alloantigen presentation and pro-inflammatory cytokine secretion. However, the early contribution of these cells following revascularization has not previously been described. We performed a secondary, high-volume preservation flush following cold storage to characterize the inflammatory contribution of the donor kidney upon reperfusion. Methods.: Porcine kidneys were retrieved using a protocol analogous to current UK clinical practice...
February 27, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28337763/automatic-washing-of-thawed-haematopoietic-progenitor-cell-grafts-a-preclinical-evaluation
#2
M Abonnenc, B Pesse, J-D Tissot, S Barelli, N Lion
BACKGROUND AND OBJECTIVES: Autologous haematopoietic progenitor cell (HPC) is a prerequisite for high-dose chemotherapy in treatment of several haematologic and non-haematologic malignancies. HPCs are collected by apheresis and cryopreserved until infusion. Postinfusion adverse events have been in part related to the dimethyl sulphoxide (DMSO) used as cryoprotectant. The aim was to evaluate (i) an automated sequential washing procedure for DMSO removal in thawed HPC grafts and (ii) washing solutions in replacement of hydroxyethyl starch (HES)-based solutions...
March 23, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28325791/individual-variations-in-nitric-oxide-synthase-dependent-sweating-in-young-and-older-males-during-exercise-in-the-heat-role-of-aerobic-power
#3
Tatsuro Amano, Naoto Fujii, Jeffrey C Louie, Robert D Meade, Glen P Kenny
We evaluated the association between aerobic power (defined by peak oxygen consumption; VO2peak) and the contribution of nitric oxide synthase (NOS) to the sweating response in young and older individuals during exercise in the heat. Data from 44 young (24 ± 1 years) and 48 older (61 ± 2 years) males with mean VO2peak of 47.8 ± 2.4 (range, 28.0-62.3) and 39.1 ± 2.3 (range, 26.4-55.7) mLO2 kg(-1) min(-1), respectively, were compiled from our prior studies. Participants performed two 15- to 30-min bouts of exercise at a fixed rate of metabolic heat production of 400 or 500 W, each separated by 15-20 min recovery in the heat (35°C, relative humidity of 20%)...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28319030/ischemic-small-intestine-in-vivo-versus-ex-vivo-bioimpedance-measurements
#4
Runar James Strand-Amundsen, Henrik Reims, Christian Tronstad, Havard Kalvoy, Orjan Martinsen, Jan Hogetveit, Tom Erik Ruud, Tor Inge Tønnessen
Bioimpedance has been used to investigate changes in electrical parameters during ischemia in various tissues. The small intestine is a multi-layered structure, with several distinct tissue types, and ischemia related changes occur at different times in the different intestinal layers. When investigating how the electrical properties in the small intestine is affected by ischemia, some researchers have used ex-vivo models while others have used in-vivo models. In this study, we compare ischemic time development of electrical parameters in ischemic in-vivo versus ex-vivo small intestine...
March 20, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28316381/in-vitro-evaluation-of-antifilarial-effect-of-azadirachta-indica-leaves-extract-in-different-solvents-on-the-microfilariae-of-setaria-cervi
#5
Sharba Kausar
Polar solvent extracts of Azadirachta indica leaves were investigated to evaluate in vitro anthelmintic activity on the microfilariae of Setaria cervi. Four extracts of A. indica leaves were prepared with different solvents in increasing order of polarity (diethyl ether < chloroform < ethanol < methanol). Stock solution of the extract of A. indica leaves was prepared in Ringer's solution at the concentrations of 50, 100 and 200 μg/ml and used against microfilariae in three replicates. Ringer's solution was used as experimental control...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28302938/effect-of-acetate-ringer-ssolution-with-or-without-5-dextrose-administered-intravenously-to-diarrheic-calves
#6
Kenji Tsukano, Satoko Kato, Shinya Sarashina, Izumi Abe, Tadaharu Ajito, Hiromichi Ohtsuka, Kazuyuki Suzuki
The objectives of this study were to evaluate the effects of intravenous acetate Ringer's solution, with or without dextrose, on diarrheic calves with either experimentally induced or spontaneous diarrhea. In the experimental model, diarrhea was induced in nine healthy calves by administering cold milk (below 4°C) twice a day for 2 days. The calves were randomly assigned to the isotonic saline (ISS), acetated Ringer's (AR), or acetated Ringer's with 5% dextrose (ARD) groups, with three calves assigned to each group...
March 12, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28302179/balanced-crystalloids-versus-saline-in-the-intensive-care-unit-study-protocol-for-a-cluster-randomized-multiple-crossover-trial
#7
Matthew W Semler, Wesley H Self, Li Wang, Daniel W Byrne, Jonathan P Wanderer, Jesse M Ehrenfeld, Joanna L Stollings, Avinash B Kumar, Antonio Hernandez, Oscar D Guillamondegui, Addison K May, Edward D Siew, Andrew D Shaw, Gordon R Bernard, Todd W Rice
BACKGROUND: Saline, the intravenous fluid most commonly administered to critically ill adults, contains a high chloride content, which may be associated with acute kidney injury and death. Whether using balanced crystalloids rather than saline decreases the risk of acute kidney injury and death among critically ill adults remains unknown. METHODS: The Isotonic Solutions and Major Adverse Renal Events Trial (SMART) is a pragmatic, cluster-level allocation, cluster-level crossover trial being conducted between 1 June 2015 and 30 April 2017 in five intensive care units at Vanderbilt University Medical Center in Nashville, TN, USA...
March 16, 2017: Trials
https://www.readbyqxmd.com/read/28295755/evidence-for-a-functional-vasoconstrictor-role-for-atp-in-the-human-cutaneous-microvasculature
#8
James A Lang, Alex C Krajek, Kevin A Smaller
Noradrenaline is responsible for eliciting ∼60% of the reflex cutaneous vasoconstriction (VC) response in young adults, whereas the remainder is due to one or more unidentified coreleased sympathetic adrenergic neurotransmitter(s). Inconsistent evidence has placed neuropeptide Y in this role; however, other putative cotransmitters have yet to be tested. We hypothesize that ATP contributes to the reflex cutaneous VC response. Two protocols were conducted in young adults (n = 10); both involved the placement of three microdialysis (MD) probes in forearm skin and whole-body cooling (Tsk  = 30...
March 10, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28295302/the-associations-between-army-national-guard-versus-active-duty-soldier-status-and-perceived-burdensomeness-thwarted-belongingness-and-acquired-capability
#9
Matthew C Podlogar, Claire Houtsma, Lauren R Khazem, Fallon Ringer, Thomas Mofield, Bradley A Green, Michael D Anestis, Ingrid C Lim, Thomas E Joiner
OBJECTIVE: This study aimed to examine if levels of thwarted belongingness, perceived burdensomeness, and acquired capability significantly differed between guardsmen and active duty soldiers. METHOD: Multivariate analysis of covariance was used to test for differences between active duty Army (n = 1,393) and Army National Guard (n = 623) groups, before and after controlling for the effects of age, gender, race, marital status, level of education, and deployment history...
March 10, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28292313/relationship-between-family-caregiver-burden-and-physical-frailty-in-older-adults-without-dementia-a-systematic-review
#10
Thom Ringer, Afeez Abiola Hazzan, Arnav Agarwal, Adam Mutsaers, Alexandra Papaioannou
BACKGROUND: Physical frailty is a prevalent syndrome in older adults that increases vulnerability for a range of adverse outcomes including increased dependency and death. Caregivers of older adults experience significant physical, emotional, and financial burden, which is associated with poor physical and mental health. While it is known that care recipients' dementia is associated with burden, the literature regarding the impact of physical frailty on burden has yet to be synthesized...
March 14, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28288697/correlating-atom-probe-crystallographic-measurements-with-transmission-kikuchi-diffraction-data
#11
Andrew J Breen, Katharina Babinsky, Alec C Day, K Eder, Connor J Oakman, Patrick W Trimby, Sophie Primig, Julie M Cairney, Simon P Ringer
Correlative microscopy approaches offer synergistic solutions to many research problems. One such combination, that has been studied in limited detail, is the use of atom probe tomography (APT) and transmission Kikuchi diffraction (TKD) on the same tip specimen. By combining these two powerful microscopy techniques, the microstructure of important engineering alloys can be studied in greater detail. For the first time, the accuracy of crystallographic measurements made using APT will be independently verified using TKD...
March 14, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28281851/antibacterial-activity-and-biofilm-inhibition-by-surface-modified-titanium-alloy-medical-implants-following-application-of-silver-titanium-dioxide-and-hydroxyapatite-nanocoatings
#12
A Besinis, S D Hadi, H R Le, C Tredwin, R D Handy
One of the most common causes of implant failure is peri-implantitis, which is caused by bacterial biofilm formation on the surfaces of dental implants. Modification of the surface nanotopography has been suggested to affect bacterial adherence to implants. Silver nanoparticles are also known for their antibacterial properties. In this study, titanium alloy implants were surface modified following silver plating, anodisation and sintering techniques to create a combination of silver, titanium dioxide and hydroxyapatite (HA) nanocoatings...
March 17, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28280470/acute-effect-of-central-administration-of-urotensin-ii-on-baroreflex-and-blood-pressure-in-conscious-normotensive-rabbits
#13
Kyungjoon Lim, Yusuke Sata, Kristy L Jackson, Sandra L Burke, Geoffrey A Head
In the present study, we examined the effects of central administration of Urotensin II on blood pressure, heart rate, and baroreceptor heart rate reflexes in conscious normotensive rabbits. Preliminary operations were undertaken to implant a balloon cuff on the inferior vena cava for baroreflex assessments and to implant cannula into the lateral and fourth ventricle. After 2 weeks of recovery cumulative dose response curves to Urotensin II (10, 100 ng, 1, 10, and 100 μg) given into the ventricles, or Ringer's solution as a vehicle were performed on separate days...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28278582/prolonging-the-shelf-life-of-lumbricus-terrestris-erythrocruorin-for-use-as-a-novel-blood-substitute
#14
Christine Muzzelo, Christopher Neely, Payal Shah, Osheiza Abdulmalik, Jacob Elmer
Limitations associated with the storage of red blood cells have motivated the development of novel blood substitutes that are able to withstand long-term storage at elevated temperatures. The hemoglobin of the earthworm Lumbricus terrestris (LtEc) is an attractive blood substitute candidate, since it is resistant to oxidation and aggregation during storage. Several factors were investigated to optimize the thermal and oxidative stability of LtEc during storage, including pH, antioxidant supplements, and deoxygenation...
February 20, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28277997/effect-of-antiseptic-irrigation-on-infection-rates-of-traumatic-soft-tissue-wounds-a-longitudinal-cohort-study
#15
B Roth, R Neuenschwander, F Brill, F Wurmitzer, C Wegner, O Assadian, A Kramer
OBJECTIVE: Acute traumatic wounds are contaminated with bacteria and therefore an infection risk. Antiseptic wound irrigation before surgical intervention is routinely performed for contaminated wounds. However, a broad variety of different irrigation solutions are in use. The aim of this retrospective, non-randomised, controlled longitudinal cohort study was to assess the preventive effect of four different irrigation solutions before surgical treatment, on wound infection in traumatic soft tissue wounds...
March 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28271576/cuticular-hydrocarbon-cues-of-immune-challenged-workers-elicit-immune-activation-in-honey-bee-queens
#16
Javier Hernández López, Ulrike Riessberger-Gallé, Karl Crailsheim, Wolfgang Schuehly
Recently, evidence has shown that variations in the cuticular hydrocarbons (CHCs) profile allow healthy honeybees to identify diseased nestmates, eliciting agonistic responses in the former. Here, we determined whether these 'immunologic cues' emitted by diseased nestmates were only detected by workers, who consequently took hygienic measures and excluded these individuals from the colony, or whether queens were also able to detect these cues and respond accordingly. Healthy honeybee queens were exposed to i) healthy, ii) Ringer-injected and iii) lipopolysaccharide (LPS)-injected nestmates by allowing direct body contact...
March 8, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28271565/prostacyclin-does-not-affect-sweating-but-induces-skin-vasodilatation-to-a-greater-extent-in-older-versus-younger-women-roles-of-no-and-kca-channels
#17
Naoto Fujii, Brendan D McNeely, Takeshi Nishiyasu, Glen P Kenny
We previously reported that prostacyclin induces cutaneous vasodilatation, but not sweating, in younger and older men. Further, we demonstrated that nitric oxide synthase (NOS) and calcium-activated potassium (KCa ) channels contribute to the prostacyclin-induced cutaneous vasodilatation in younger men, although these contributions are diminished in older men. Given the effects of ageing may differ between men and women, the above results cannot be simply applied to women. In this study, cutaneous vascular conductance (CVC) and sweat rate were evaluated in younger (22 ± 3 years) and older (55 ± 7 years) women (10 per group) at four intradermal forearm skin sites treated with either: (1) lactated Ringers without any drug (Control), (2) 10 mm L-NNA, a non-specific NOS inhibitor, (3) 50 mm tetraethylammonium (TEA), a non-specific KCa channel blocker, or (4) 10 mm L-NNA + 50 mm TEA...
March 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28269211/novel-ti-nb-alloys-with-improved-wear-resistance-for-biomedical-implant-application
#18
Praveen Chapala, Swati Ghosh Acharyya, S M Shariff, Ganesh Naik
The present study involved fabrication of titanium niobium based alloys having elastic modulus close to that of human bone and subsequently determining the wear resistance of these alloys for biomedical application. In the present study three beta stabilized titanium niobium alloys having composition Ti-24Nb-4Zr-8Sn, Ti-35Nb-4Sn and Ti-29Nb-13Ta-7Zr were made by vacuum arc melting. The alloys were then aged at 1000 C for 6 hours in an argon atmosphere. Detailed microstructural characterization and phase identification was carried out using scanning electron microscopy and x-ray diffraction respectively...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266591/early-aggressive-hydration-hastens-clinical-improvement-in-mild-acute-pancreatitis
#19
James L Buxbaum, Michael Quezada, Ben Da, Niraj Jani, Christianne Lane, Didi Mwengela, Thomas Kelley, Paul Jhun, Kiran Dhanireddy, Loren Laine
OBJECTIVES: Early aggressive intravenous hydration is recommended for acute pancreatitis treatment although randomized trials have not documented benefit. We performed a randomized trial of aggressive vs. standard hydration in the initial management of mild acute pancreatitis. METHODS: Sixty patients with acute pancreatitis without systemic inflammatory response syndrome (SIRS) or organ failure were randomized within 4 h of diagnosis to aggressive (20 ml/kg bolus followed by 3 ml/kg/h) vs...
March 7, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28266133/effectiveness-of-a-polyhexanide-irrigation-solution-on-methicillin-resistant-staphylococcus-aureus-biofilms-in-a-porcine-wound-model
#20
Stephen C Davis, Andrew Harding, Joel Gil, Fernando Parajon, Jose Valdes, Michael Solis, Alex Higa
Irrigation and removal of necrotic debris can be beneficial for proper healing. It is becoming increasingly evident that wounds colonized with biofilm forming bacteria, such as Staphylococcus aureus (SA), can be more difficult to eradicate. Here we report our findings of the effects of an irrigation solution containing propyl-betaine and polyhexanide (PHMB) on methicillin-resistant Staphylococcus aureus (MRSA) biofilms in a porcine wound model. Thirty-nine deep partial thickness wounds were created with six wounds assigned to one of six treatment groups: (i) PHMB, (ii) Ringer's solution, (iii) hypochlorous acid/sodium hypochlorite, (iv) sterile water, (v) octenidine dihydrochloride, and (vi) octenilin...
March 7, 2017: International Wound Journal
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