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Singapore metabolic syndrome

Henry Ko, Helena Teede, Lisa Moran
BACKGROUND: Polycystic ovary syndrome (PCOS) is a condition that affects women of reproductive age and manifests with adverse reproductive, metabolic and psychological consequences. Evidence-based PCOS guidelines recommend lifestyle management first line for infertility. In Singapore women with PCOS can attend the PCOS Clinic at the Kandang Kerbau Women and Children's Hospital for infertility treatment. However lifestyle integration into infertility management is currently limited and barriers and enablers to progress remain unclear...
2016: BMC Research Notes
Tze Pin Ng, Liang Feng, Ma Shwe Zin Nyunt, Lei Feng, Qi Gao, May Li Lim, Simon L Collinson, Mei Sian Chong, Wee Shiong Lim, Tih Shih Lee, Philip Yap, Keng Bee Yap
IMPORTANCE: The association of the metabolic syndrome (MetS) and component cardiovascular risk factors with the risk of developing mild cognitive impairment (MCI) and MCI progression to dementia is not well established. OBJECTIVE: To investigate the association of the MetS and its component cardiovascular risk factors with the incidence of MCI and its progression to dementia. DESIGN, SETTING, AND PARTICIPANTS: Prospective longitudinal study from September 1, 2003, through December 31, 2009, in communities in 5 districts in the South East region of Singapore...
April 2016: JAMA Neurology
George B B Goh, Clarence Kwan, Sze Ying Lim, Nanda Kk Venkatanarasimha, Rafidah Abu-Bakar, Thinesh L Krishnamoorthy, Hang Hock Shim, Kiang Hiong Tay, Wan Cheng Chow
BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is closely related to metabolic syndrome and its risk factors. Worldwide, epidemiological studies have reported NAFLD prevalence rates of 5% to 30% depending on geographical variations. While epidemiological data suggest a progressively increasing prevalence of metabolic risk factors in Singapore, there are limited data about NAFLD per se in the community. We aim to explore the prevalence and perceptions of NAFLD in Singapore...
May 2016: Gastroenterology Report
Sumanto Haldar, Siok Ching Chia, Christiani Jeyakumar Henry
Within the last four decades Asia has witnessed major transformation in its population demographics, which gave rise to changes in food availability, food habits and lifestyle. A significant consequence of these changes has been the continuing rise in overweight and obesity across Asia. In parallel, there has been a significant rise in Asians in the incidence of the major chronic diseases, particularly in cardiometabolic disorders such as metabolic syndrome, type 2 diabetes, hypertension, and other cardiovascular diseases...
2015: Advances in Food and Nutrition Research
Hwee Leong Tan, Kieron B L Lim, Shridhar Ganpathi Iyer, Stephen K Y Chang, Krishnakumar Madhavan, Alfred W C Kow
BACKGROUND: With improvements in patient survival after a liver transplantation (LT), long-term sequelae such as metabolic syndrome (MS) have become increasingly common. This study aims to characterize the prevalence, associations and long-term outcomes of post-LTMS and its components in an Asian population. METHODS: A retrospective review of all adult patients who underwent LT at the National University Health System Singapore between December 1996 and May 2012 was performed...
August 2015: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
S Tavintharan, Li Ting Sharon Pek, Jian Jun Liu, Xiao Wei Ng, Lee Ying Yeoh, Lim Su Chi, Sum Chee Fang
AIMS: Osteoprotegerin (OPG) is a glycoprotein from tumour necrosis factor receptor superfamily, responsible for osteoclastogenesis inhibition and associated with arterial calcification and stiffness. We describe the association between metabolic syndrome (MS) and OPG in type 2 diabetes mellitus patients. METHODOLOGY: We consecutively enrolled 1220 patients from our institution's Diabetes Centre from August 2011. Anthropometric data such as fasting blood/urine were obtained, and OPG was measured by enzyme-linked immunosorbent assay (ELISA)...
September 2014: Diabetes & Vascular Disease Research
(no author information available yet)
BACKGROUND: High blood pressure, blood glucose, serum cholesterol, and BMI are risk factors for cardiovascular diseases and some of these factors also increase the risk of chronic kidney disease and diabetes. We estimated mortality from cardiovascular diseases, chronic kidney disease, and diabetes that was attributable to these four cardiometabolic risk factors for all countries and regions from 1980 to 2010. METHODS: We used data for exposure to risk factors by country, age group, and sex from pooled analyses of population-based health surveys...
August 2014: Lancet Diabetes & Endocrinology
Simon L Collinson, Sandy J F Tong, Sarah S K Loh, S B Chionh, Reshma A Merchant
BACKGROUND: An association between metabolic syndrome (MetS) and disturbances in neurocognitive function has been identified in Caucasians but the nature and extent of impaired cognition in Asian MetS patients, who may be at greater risk of degenerative cognitive decline, remains unspecified. METHODS: A cross-sectional study was conducted at the National University Hospital of Singapore. Participants were recruited from a diabetes clinic at the National University Hospital...
August 2014: International Psychogeriatrics
Milawaty Nurjono, Jimmy Lee
INTRODUCTION: Metabolic Syndrome (MetS) is associated with cardiovascular morbidity and mortality. Studies proposed that waist circumference (WC) and body mass index (BMI) are good indicators of MetS. In this study, we examined and compared the predictive utility of clinical measures such as WC, blood pressure and BMI and determined the cutoff points in which these measures are most reliable in identifying MetS in Singaporean Chinese. MATERIALS AND METHODS: Two hundred and forty-four subjects aged between 21 and 50 years of Chinese ethnicity were recruited into the study...
May 2013: Annals of the Academy of Medicine, Singapore
E C E Wang, K J Ker, S Y Chuah, J Y Pan
BACKGROUND: Psoriasis has been linked with cardiovascular risk factors (CVRFs), including the metabolic syndrome, yet many patients with psoriasis remain unscreened. OBJECTIVE: To assess the reasons for lack of screening for CVRFs in psoriasis patients, and the impact of an education programme targeting these deficiencies. METHODS: All patients with psoriasis, regardless of severity, and all dermatologists working at the National Skin Centre (NSC) in Singapore were surveyed over a 2-month period on their attitudes and knowledge regarding psoriasis and cardiovascular risk...
June 2014: Journal of the European Academy of Dermatology and Venereology: JEADV
Charumathi Sabanayagam, Boon Wee Teo, E Shyong Tai, Tazeen H Jafar, Tien Y Wong
OBJECTIVE: To examine the ethnic differences in the association between metabolic syndrome components and CKD in Asian populations. METHODS: We analyzed data from three independent populations in Singapore representing the three major Asian ethnic groups (n=3167 Chinese, 3082 Malays and 3228 Indians) aged 40-80 years. CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m(2). Factor analysis of metabolic syndrome components was conducted and factor scores were used as independent variables in multivariable logistic regression models...
April 2013: Maturitas
Liang Feng, Mei Sian Chong, Wee Shiong Lim, Tih Shih Lee, Simon L Collinson, Philip Yap, Tze Pin Ng
Metabolic syndrome (MetS) is reported to be associated with cognitive decline and dementia, in particular vascular dementia. However, the evidence linking MetS to Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), a precursor of AD, is inconsistent and limited. This study examined the association of MetS and its components with aMCI and how APOE-εe4 and younger age influenced this association. Participants with aMCI (n = 98) and cognitively normal controls (n = 802) were identified from baseline data in a second wave cohort of older subjects aged 55 and over in the Singapore Longitudinal Ageing Study-2 (SLAS-2) in 2009/2010...
2013: Journal of Alzheimer's Disease: JAD
Jimmy Lee, Milawaty Nurjono, Audrey Wong, Agus Salim
INTRODUCTION: Schizophrenia has been associated with an increased risk of cardiometabolic morbidity and mortality. Metabolic syndrome (MetS), a reliable predictor of cardiovascular-related morbidity and mortality, has also been shown to be more prevalent in patients with schizophrenia. In this study, we investigated the prevalence of MetS in a sample of patients with schizophrenia in Singapore, and the potential risk factors associated with it. MATERIALS & METHODS: One hundred patients with schizophrenia and 300 community controls were recruited...
October 2012: Annals of the Academy of Medicine, Singapore
Milawaty Nurjono, Jimmy Lee
AIMS: This study aims to examine and compare the predictive utility of blood pressure (BP), waist circumference (WC) and body mass index (BMI), and to determine optimal cut-off values in prediction of metabolic syndrome (MetS) in patients with chronic schizophrenia. METHODS: About 100 patients with chronic schizophrenia were recruited. BMI and BP were measured and laboratory tests to evaluate patients' high-density lipoprotein cholesterol, triglycerides and glucose levels were performed...
May 2013: Early Intervention in Psychiatry
Charumathi Sabanayagam, Jie Jin Wang, Paul Mitchell, Ava Grace Tan, E Shyong Tai, Tin Aung, Seang-Mei Saw, Tien Yin Wong
PURPOSE: To examine the relationship between metabolic syndrome and its components, diabetes mellitus, high blood pressure (BP), obesity, and dyslipidemia, with age-related cataract. METHODS: A population-based sample of 2794 Malay adults aged 40 to 80 years in Singapore was used for this analysis. Cataract (n = 1268) was defined as the presence of nuclear, cortical, or posterior subcapsular (PSC) cataract, from standardized grading of lens photographs or previous cataract surgery...
April 2011: Investigative Ophthalmology & Visual Science
Deidre Anne De Silva, Fung-Peng Woon, Moi-Pin Lee, Christopher Li-Hsian Chen, Hui-Meng Chang, Meng-Cheong Wong
BACKGROUND: The association of metabolic syndrome (MetS) and intracranial large artery disease (ICLAD) has been described, but only in cohorts of ethnic Korean patients with stroke. We investigated the relationship of MetS and ICLAD among ethnic Chinese patients. METHODS: This is a prospective study of consecutive ethnic Chinese patients with acute ischemic stroke living in Singapore. ICLAD was diagnosed on transcranial color-coded Doppler or magnetic resonance angiography...
November 2009: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Gavin S Tan, Tien Y Wong, Chee-Weng Fong, Tin Aung
OBJECTIVE: To examine the relationship of diabetes mellitus and metabolic abnormalities with intraocular pressure and glaucoma. METHODS: A population-based study was conducted in 3280 (78.7% response) Malay adults aged 40 to 80 years. Diabetes was defined as a random serum glucose level of 200 mg/dL or greater or physician diagnosis of diabetes mellitus. Metabolic abnormalities including body mass index, lipid levels, and blood pressure were measured. Glaucoma was defined from a standardized examination by means of the International Society for Geographical and Epidemiological Ophthalmology criteria...
October 2009: Archives of Ophthalmology
Swapna K Verma, Mythily Subramaniam, Alvin Liew, Lye Yin Poon
OBJECTIVE: Metabolic risk factors, such as obesity, as well as abnormalities in glucose and lipid metabolism, have been shown to have an increased prevalence in patients with schizophrenia, especially in those treated with antipsychotic medication. However, studies looking at these abnormalities in drug-naive patients have been few in number and have yielded mixed results. The aim of our study was to look at the prevalence of some of the cardiovascular risk factors, such as obesity and lipid and glucose abnormalities, in drug-naive patients with first-episode psychosis compared to healthy controls matched for age, gender, and ethnicity...
July 2009: Journal of Clinical Psychiatry
Daniel H W Su, Tien Y Wong, Paul J Foster, Wan-Ting Tay, Seang-Mei Saw, Tin Aung
PURPOSE: To examine the association between central corneal thickness (CCT) and potential systemic and ocular factors affecting CCT in an Asian population. DESIGN: Population-based cross-sectional study. METHODS: A total of 3,280 (78.7% response) adults aged 40 to 80 years of Malay ethnicity living in Singapore underwent a standardized interview and ocular and systemic examination at a centralized study clinic. CCT was measured with an ultrasound pachymeter...
April 2009: American Journal of Ophthalmology
Jenny P L Tang
INTRODUCTION: Obesity affects about 10% to 15% of our school-going population in Singapore and is a risk factor for development of obstructive sleep apnoea hypopnoea syndrome (OSAHS). This article reviews the prevalence, aetiology, pathophysiology, diagnosis, complications and treatment of obese children with OSAHS with particular reference to children in Singapore. METHODS: Review of articles or conference papers reporting data with regards to OSAHS in Singapore children...
August 2008: Annals of the Academy of Medicine, Singapore
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