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Singapore obesity

Xuling Chang, Rajkumar Dorajoo, Ye Sun, Yi Han, Ling Wang, Chiea-Chuen Khor, Xueling Sim, E-Shyong Tai, Jianjun Liu, Jian-Min Yuan, Woon-Puay Koh, Rob M van Dam, Yechiel Friedlander, Chew-Kiat Heng
BACKGROUND: Recent genome-wide association studies (GWAS) have identified 97 body-mass index (BMI) associated loci. We aimed to evaluate if dietary intake modifies BMI associations at these loci in the Singapore Chinese population. METHODS: We utilized GWAS information from six data subsets from two adult Chinese population (N = 7817). Seventy-eight genotyped or imputed index BMI single nucleotide polymorphisms (SNPs) that passed quality control procedures were available in all datasets...
February 24, 2018: Nutrition Journal
Harinakshi Sanikini, Jian-Min Yuan, Lesley M Butler, Woon-Puay Koh, Yu-Tang Gao, Annika Steffen, Mattias Johansson, Paolo Vineis, Gary E Goodman, Matt J Barnett, Rayjean J Hung, Chu Chen, Isabelle Stücker
BACKGROUND: Obesity has been proposed as a potential protective factor against lung cancer. We examined the association between BMI and lung cancer risk in a pooled analysis based on nested case-control studies from four cohort studies. METHODS: A case-control study was nested within four cohorts in USA, Europe, China and Singapore that included 4172 cases and 8471 control subjects. BMI at baseline was calculated as weight in kilograms divided by height in meters squared (kg/m2 ), and classified into 4 categories: underweight (BMI < 18...
February 23, 2018: BMC Cancer
B C Toh, W H Chan, Akh Eng, Ekw Lim, C H Lim, K W Tham, S Fook-Chong, Jth Tan
Bariatric surgery is an effective treatment for morbid obesity and its metabolic related comorbidities - Type II Diabetes, Hypertension and Hyperlipidaemia.1 However, the literature is scarce regarding the long-term outcome after bariatric surgery especially among multi-ethnic Asian populations. Considering the growing number of bariatric metabolic operations in Asia, we have attempted to provide a regional perspective on 5-year long-term clinical outcomes post bariatric surgery in Singapore. Between years 2010 to 2016, all bariatric operative cases consisted of 393 Laparoscopic Sleeve Gastrectomy (LSG), 125 Laparoscopic Roux-En-Y Gastric Bypass (RYGB) and 43 Laparoscopic Mini-gastric Bypass (MGB) were included...
February 20, 2018: Diabetes, Obesity & Metabolism
Marc Weijie Ong, Chun Hai Tan, Anton Kui Sing Cheng
PURPOSE: Low vitamin D status is prevalent worldwide and has been linked to a variety of pathologies including obesity in adults. The severity of vitamin D deficiency amongst the overweight and obese Singaporeans is not well documented. The purpose of this prospective observational study was to assess the prevalence and determinants of vitamin D deficiency in a multi-ethnic Asian population referred for weight management, including those seeking bariatric surgery. MATERIALS AND METHODS: This was a cross-sectional study conducted among 111 consecutive subjects referred to a single institution weight management service in Singapore...
February 16, 2018: Obesity Surgery
Phong Ching Lee, Kwang Wei Tham, Sonali Ganguly, Hong Chang Tan, Alvin Kim Hock Eng, John B Dixon
BACKGROUND: In Asia, metabolic-bariatric surgery (MBS) rates have grown rapidly in parallel with rising prevalence of obesity and type 2 diabetes (T2D). OBJECTIVE: The objective of this study was to identify factors that influence glycemic outcomes and diabetes remission 12 months after sleeve gastrectomy (SG) or gastric bypass (GB) in a multiethnic Asian cohort. SETTING: The study's setting was in a tertiary hospital in Singapore. METHODS: Data from 145 T2D patients who had SG (37%) or GB (63%) and at least 1-year follow-up were analyzed...
December 26, 2017: Obesity Surgery
Taiki Kojima, Elizabeth K Laverriere, Erin B Owen, Ilana Harwayne-Gidansky, Asha N Shenoi, Natalie Napolitano, Kyle J Rehder, Michelle A Adu-Darko, Sholeen T Nett, Debbie Spear, Keith Meyer, John S Giuliano, Keiko M Tarquinio, Ronald C Sanders, Jan Hau Lee, Dennis W Simon, Paula A Vanderford, Anthony Y Lee, Calvin A Brown, Peter W Skippen, Ryan K Breuer, Iris Toedt-Pingel, Simon J Parsons, Eleanor A Gradidge, Lily B Glater, Kathleen Culver, Simon Li, Lee A Polikoff, Joy D Howell, Gabrielle Nuthall, Gokul K Bysani, Ana L Graciano, Guillaume Emeriaud, Osamu Saito, Alberto Orioles, Karen Walson, Philipp Jung, Awni M Al-Subu, Takanari Ikeyama, Rakshay Shetty, Kathleen M Yoder, Vinay M Nadkarni, Akira Nishisaki
OBJECTIVES: External laryngeal manipulation is a commonly used maneuver to improve visualization of the glottis during tracheal intubation in children. However, the effectiveness to improve tracheal intubation attempt success rate in the nonanesthesia setting is not clear. The study objective was to evaluate the association between external laryngeal manipulation use and initial tracheal intubation attempt success in PICUs. DESIGN: A retrospective observational study using a multicenter emergency airway quality improvement registry...
February 2018: Pediatric Critical Care Medicine
Evelyn Boon, Kelly Ann Zainal, Stephen W Touyz
BACKGROUND: Despite the increasing number of patients presenting for treatment, little is still known about male eating disorders cases. The current study presents four male eating disorder cases presented to our specialized treatment facility in Singapore. CASE PRESENTATION: Cases 1, 2 and 3 are homosexual males in their twenties and thirties who presented with anorexia nervosa and bulimia nervosa. Case 4 is a heterosexual male in his twenties diagnosed with binge eating disorder...
2017: Journal of Eating Disorders
Natarajan Padmapriya, Jonathan Y Bernard, Shen Liang, See Ling Loy, Shirong Cai, Iris Shen Zhe, Kenneth Kwek, Keith M Godfrey, Peter D Gluckman, Seang Mei Saw, Yap-Seng Chong, Jerry Kok Yen Chan, Falk Müller-Riemenschneider
BACKGROUND: Few studies have investigated physical activity (PA) and sedentary behavior (SB) in relation to fasting (FG) and 2-h postprandial plasma glucose (2hPG) levels and gestational diabetes mellitus (GDM); we investigated these associations among Asian pregnant women. METHODS: As part of the Growing Up in Singapore Towards healthy Outcomes cohort study, PA and SB (sitting and television times) were assessed by interviewer-administered questionnaire. During 75 g oral glucose tolerance tests at 26-28 weeks' gestation we measured FG, 2hPG levels and GDM (FG ≥ 7...
October 18, 2017: BMC Pregnancy and Childbirth
Joannie Lortet-Tieulent, Jacques Ferlay, Freddie Bray, Ahmedin Jemal
Background: Cancers of the corpus uteri-primarily of the endometrium-rank as the sixth most common neoplasm in women worldwide. Analyses of the global patterns and trends of uterine cancer rates are needed in view of the ongoing obesity epidemic, a major risk factor for the disease. Methods: Data on endometrial cancer (ICD-10 C54) incidence from population-based cancer registries in 43 populations, published in CI5plus or by registries, were extracted for 1978 to 2013...
October 16, 2017: Journal of the National Cancer Institute
Narayanaswamy Venketasubramanian, Byung Woo Yoon, Jeyaraj Pandian, Jose C Navarro
Asia, which holds 60% of the world's population, comprises some developing countries which are in economic transition. This paper reviews the epidemiology of stroke in South, East and South-East Asia. Data on the epidemiology of stroke in South, East, and South-East Asia were derived from the Global Burden of Disease study (mortality, disability-adjusted life-years [DALYs] lost because of stroke), World Health Organization (vascular risk factors in the community), and publications in PubMed (incidence, prevalence, subtypes, vascular risk factors among hospitalized stroke patients)...
September 2017: Journal of Stroke
L-W Chen, M-T Tint, M V Fortier, I M Aris, Lp-C Shek, K H Tan, S-Y Chan, P D Gluckman, Y-S Chong, K M Godfrey, V S Rajadurai, F Yap, M S Kramer, Y S Lee
BACKGROUND: Studying the determinants and the long-term consequences of fetal adipose accretion requires accurate assessment of neonatal body composition. In large epidemiological studies, in-depth body composition measurement methods are usually not feasible for cost and logistical reasons, and there is a need to identify anthropometric measures that adequately reflect neonatal adiposity. METHODS: In a multiethnic Asian mother-offspring cohort in Singapore, anthropometric measures (weight, length, abdominal circumference, skinfold thicknesses) were measured using standardized protocols in newborn infants, and anthropometric indices [weight/length, weight/length(2) (body mass index, BMI), weight/length(3) (ponderal index, PI)] derived...
October 9, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Dallan Dargan, Dmitrii Dolgunov, Khin Thida Soe, Pamela Er, Fathimath Naseer, Davide Lomanto, Jimmy By So, Asim Shabbir
INTRODUCTION: Laparoscopic sleeve gastrectomy (LSG) outcomes among adolescents and adolescent obesity associated factors in Singapore were evaluated. METHODS: Prospectively collected data of patients aged 16-19 years at first presentation who underwent LSG was retrospectively reviewed. A questionnaire was completed incorporating cigarette, alcohol, dietary and exercise habits; family history of obesity; Berlin and Epworth scores; and Patient Health Questionnaire-9 (PHQ-9) scores...
October 6, 2017: Singapore Medical Journal
Patricia C Valery, Mathieu Laversanne, Paul J Clark, Jessica L Petrick, Katherine A McGlynn, Freddie Bray
Primary liver cancer (PLC) is the sixth most common cancer worldwide and the second most common cause of cancer death. Future predictions can inform health planners and raise awareness of the need for cancer control action. We predicted the future burden of PLC in 30 countries around 2030. Incident cases of PLC (International Classification of Diseases, Tenth Revision, C22) were obtained from 30 countries for 1993-2007. We projected new PLC cases to 2030 using age-period-cohort models (NORDPRED software). Age-standardized incidence rates per 100,000 person-years were calculated by country and sex...
August 31, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
S Cai, P Natarajan, J K Y Chan, P C Wong, K H Tan, K M Godfrey, P D Gluckman, L P C Shek, F Yap, M S Kramer, S Y Chan, Y S Chong
STUDY QUESTION: Does IVF independently increase the risk of gestational diabetes mellitus (GDM) and is this increase in risk modified by maternal body mass index? SUMMARY ANSWER: IVF appears to be an independent risk factor for GDM and elevated blood glucose levels in overweight women (BMI > 25 kg/m2). WHAT IS KNOWN ALREADY: IVF has been associated with increased risk of GDM, but most previous studies did not adequately assess confounding or effect modification by other risk factors...
September 1, 2017: Human Reproduction
Izzuddin M Aris, Ling-Wei Chen, Mya Thway Tint, Wei Wei Pang, Shu E Soh, Seang-Mei Saw, Lynette Pei-Chi Shek, Kok-Hian Tan, Peter D Gluckman, Yap-Seng Chong, Fabian Yap, Keith M Godfrey, Michael S Kramer, Yung Seng Lee
We investigated body mass index (BMI) trajectories in the first 2 years of life in 1170 children from an Asian mother-offspring cohort in Singapore, and examined their predictors and associations with childhood cardio-metabolic risk measures at 5 years. Latent class growth mixture modelling analyses were performed to identify distinct BMI z-score (BMIz) trajectories. Four trajectories were identified: 73.2%(n = 857) of the children showed a normal BMIz trajectory, 13.2%(n = 155) a stable low-BMIz trajectory, 8...
August 21, 2017: Scientific Reports
Claire Alexandra Zhen Chew, Ian Jse-Wei Tan, Hannah Jia Hui Ng, Davide Lomanto, Jimmy So, Asim Shabbir
BACKGROUND: Laparoscopic sleeve gastrectomy (SG) is a popular bariatric procedure in morbidly obese Asians. OBJECTIVES: To investigate the effect of initial weight loss on midterm weight maintenance and remission of co-morbidities after laparoscopic SG in morbidly obese Asians. SETTING: University Hospital, Singapore. METHODS: Data of patients who underwent laparoscopic SG were analyzed. Change in body mass index (BMI), percentage of total weight loss (%WL), and of excess weight loss (%EWL) was calculated and remission of obesity-related co-morbidities was examined...
December 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Tze Pin Ng, Aizhen Jin, Khuan Yew Chow, Liang Feng, Ma Shwe Zin Nyunt, Keng Bee Yap
OBJECTIVES: The relationship between body mass index (BMI) with mortality risk, in particular the BMI category associated with the lowest all-cause and CVD-and-stroke mortality and the BMI threshold for defining overweight or obesity in older persons is controversial. This study investigated the age-dependent associations of BMI categories with all-cause and cardiovascular disease (CVD) and stroke mortality. METHOD: Prospective cohort study (Singapore Longitudinal Ageing Studies) of older adults aged 55 and above, followed up from 2003 to 2011...
2017: PloS One
Tunn Ren Tay, Hang Siang Wong, Rosna Ihsan, Hsiao Peng Toh, Xuening Choo, Augustine Kh Tee
INTRODUCTION: Understanding the burden of uncontrolled severe asthma is essential for disease-targeted healthcare planning. There is a scarcity of data regarding the proportion, healthcare utilisation and costs of patients with uncontrolled severe asthma in Asia. This study aimed to plug the knowledge gap in this area. MATERIALS AND METHODS: Consecutive patients with asthma managed in our respiratory specialist clinic were evaluated prospectively. Healthcare utilisation comprising unscheduled asthma-related primary care visits, emergency department (ED) visits and hospital admissions were obtained from the national health records system...
June 2017: Annals of the Academy of Medicine, Singapore
Jun Jie Ng, Wei Qi Leong, Chuen Seng Tan, Keah How Poon, Davide Lomanto, Jimmy B Y So, Asim Shabbir
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is one of the most commonly performed procedures for the treatment of obesity. Patients with obesity are more prone to experience opioid-related adverse events (ORAE). OBJECTIVES: The objective of this study is to determine if a multimodal analgesia protocol (MAP) reduces ORAE and provides effective pain relief for patients after LSG. SETTING: This study was conducted at University Hospital, Singapore...
December 2017: Obesity Surgery
Timothy Yong Qun Leow, Andrew Ung, Shelley Qian, Jessie Thanh Nguyen, Yvonne An, Poonam Mudgil, John Whitehall
BACKGROUND: Infant feeding practices are known to influence the child's long-term health. Studies have associated obesity and other diseases with reduced breastfeeding and early introduction of high calorie beverages (HCBs). The rising prevalence of obesity is already a problem in most developed countries, especially Australia, but cultural differences are influential. Our aim is to examine and compare infant feeding practices and educational levels of respondents through questionnaires in three culturally different sites: Campbelltown (South Western Sydney), Australia, Singapore and Ho Chi Minh City, Vietnam (HCMC)...
June 13, 2017: BMC Pediatrics
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