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https://www.readbyqxmd.com/read/28805762/-a-study-of-combination-treatment-with-nacom-levodopa-carbodope-and-citicoline-in-the-model-of-parkinson-disease-in-rats
#1
V A Kashkin, E V Shekunova, M N Makarova, V G Makarov
AIM: To evaluate the efficacy of the combined use of citicoline (neipilept) and levodopa/carbidopa (nakom) in the rotenone model of Parkinson's disease in rats. MATERIAL AND METHODS: Rotenone was administrated during 14 days in dose 2 mg/kg/day subcutaneously. The duration of treatment was 7 days, intragastrically. Alteration of locomotor behavior components, muscular rigidity in resistance to passive flexion in the ankle joint and signs of extrapyramidal disorders were assessed...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28805066/active-controlled-motion-in-early-rehabilitation-improves-outcome-after-ankle-fractures-a-randomized-controlled-trial
#2
Hendrik Jansen, Martin Jordan, Sönke Frey, Stefanie Hölscher-Doht, Rainer Meffert, Timo Heintel
OBJECTIVE: To evaluate the use of active controlled motion (ACM) after unstable ankle fractures needing initial partial weight-bearing. DESIGN: Prospective randomized controlled trial. SETTING: Inpatient and outpatient clinic. SUBJECTS: A total of 50 patients with unstable ankle fractures and the need for partial weight-bearing for six weeks. INTERVENTIONS: Randomization in two groups: physiotherapy alone or physiotherapy with an additional ACM device...
August 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28803825/cardiovascular-events-after-exposure-to-nilotinib-in-chronic-myeloid-leukemia-long-term-follow-up
#3
Nazanin Aghel, Jeffrey Howard Lipton, Eshetu G Atenafu, Dennis Dong Hwan Kim, Diego Hernan Delgado
INTRODUCTION: Nilotinib is a highly effective tyrosine kinase inhibitor in the treatment of chronic myeloid leukemia (CML). However, reports of cardiovascular toxicities caused by nilotinib have recently raised critical concerns. The aim of the present study was to evaluate the incidence of cardiovascular events (CVEs) and frequency of asymptomatic peripheral arterial disease (PAD) after long-term exposure to nilotinib. PATIENTS AND METHODS: In the present retrospective cohort, we evaluated the incidence of CVEs in 63 CML patients treated with nilotinib...
July 15, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28800719/total-ankle-arthroplasty-comparing-perioperative-outcomes-when-performed-at-an-orthopaedic-specialty-hospital-versus-an-academic-teaching-hospital
#4
David M Beck, Eric M Padegimas, David I Pedowitz, Steven M Raikin
BACKGROUND: The number of total ankle arthroplasties (TAAs) performed in the United States has risen significantly in recent years, as has utilization of orthopaedic specialty hospital (OSH) to treat healthy patients undergoing elective surgery. The purpose of this study was to compare postoperative outcomes following TAA at an OSH when compared with a matching population of patients undergoing TAA at an academic teaching hospital (ATH). METHODS: We identified all TAA from January 2014 to December 2014 at the OSH and January 2010 to January 2016 at the ATH...
August 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28799033/isolated-atrophy-of-the-abductor-digiti-quinti-in-patients-with-rheumatoid-arthritis
#5
Ricardo Andrade Fernandes de Mello, Ronaldo Garcia Rondina, Valéria Valim, Stéphano Santos Belisario, Rafael Burgomeister Lourenço, Elton Francisco Batista, Ruben Horst Duque
OBJECTIVE: We aim to discuss the association of isolated atrophy of the abductor digiti quinti muscle in patients with rheumatoid arthritis as well as review the anatomy and imaging findings of this condition on MRI. MATERIALS AND METHODS: A consecutive series of 55 patients diagnosed with rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria were recruited. MRI of the clinically dominant feet was performed using a 1.5-T scanner. RESULTS: The study population was predominantly female (94...
August 10, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28797237/validity-of-the-global-physical-activity-questionnaire-gpaq-in-bangladesh
#6
Shirin Jahan Mumu, Liaquat Ali, Anthony Barnett, Dafna Merom
BACKGROUND: Feasible and cost-effective as well as population specific instruments for monitoring physical activity (PA) levels are needed for the management and prevention of non-communicable diseases. The WHO-endorsed Global Physical Activity Questionnaire (GPAQ) has been widely used in developing countries, but the evidence base for its validity, particularly for rural populations, is still limited. The aim of the study was to validate GPAQ among rural and urban residents in Bangladesh...
August 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28795888/effective-wound-bed-preparation-using-maggot-debridement-therapy-for-patients-with-critical-limb-ischaemia
#7
A Nishijima, M Gosho, R Yoshida, S Yanagibayashi, M Takikawa, J Nishijima, M Sekido, N Yamamoto
OBJECTIVE: Patients with critical limb ischaemia (CLI) lack sufficient blood flow in to the limb, which leads to difficulties in the normal wound healing process. Therefore, maggot debridement therapy (MDT) has not generally been recommended for CLI patients. We evaluated the effectiveness of wound bed preparation by MDT in CLI patients who had undergone mid-foot amputation. METHODS: Patients who underwent mid-foot amputation after angioplasty between April 2014 and October 2016 were retrospectively investigated by classifying them into an MDT group or a conventional treatment group...
August 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28783473/heel-rise-height-deficit-1-year-after-achilles-tendon-rupture-relates-to-changes-in-ankle-biomechanics-6-years-after-injury
#8
Annelie Brorsson, Richard W Willy, Roy Tranberg, Karin Grävare Silbernagel
BACKGROUND: It is unknown whether the height of a heel-rise performed in the single-leg standing heel-rise test 1 year after an Achilles tendon rupture (ATR) correlates with ankle biomechanics during walking, jogging, and jumping in the long-term. PURPOSE: To explore the differences in ankle biomechanics, tendon length, calf muscle recovery, and patient-reported outcomes at a mean of 6 years after ATR between 2 groups that, at 1-year follow-up, had less than 15% versus greater than 30% differences in heel-rise height...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28781862/acute-arterial-occlusion-after-total-knee-arthroplasty-a-case-report
#9
Kei Inomata, Ichiro Sekiya, Koji Otabe, Tomomasa Nakamura, Masafumi Horie, Hideyuki Koga, Toshifumi Watanabe, Takeshi Muneta
Popliteal artery occlusion after total knee arthroplasty is rare (0.03-0.17%) but can lead to amputation if overlooked. We should carefully assess vascular patency by Doppler ultrasound and ankle brachial pressure index (ABPI) measurement before and after total knee arthroplasty (TKA) operation.
August 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28780277/novel-methodology-for-estimating-initial-contact-events-from-accelerometers-positioned-at-different-body-locations
#10
Siddhartha Khandelwal, Nicholas Wickström
Identifying Initial Contact events (ICE) is essential in gait analysis as they segment the walking pattern into gait cycles and facilitate the computation of other gait parameters. As such, numerous algorithms have been developed to identify ICE by placing the accelerometer at a specific body location. Simultaneously, many researchers have studied the effects of device positioning for participant or patient compliance, which is an important factor to consider especially for long-term studies in real-life settings...
July 12, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28777279/fat-graft-and-bone-wax-interposition-provides-better-functional-outcomes-and-lower-reossification-rates-than-extensor-digitorum-brevis-after-calcaneonavicular-coalition-resection
#11
Javier Masquijo, Victoria Allende, Armando Torres-Gomez, Matthew B Dobbs
BACKGROUND: Calcaneonavicular coalitions are the most common form of tarsal coalitions. The prefered treatment for symptomatic coalitions is surgical resection; however, there are no published studies that directly compare different interposition techniques. The purpose of the present study was to retrospectively compare pain relief, functional outcomes, and complications of children and adolescents who had a resection of a symptomatic calcaneonavicular coalition with interposition of fat graft, bone wax, or extensor digitorum brevis (EDB)...
August 2, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28775193/the-american-orthopaedic-foot-and-ankle-society-ankle-hindfoot-scale-translation-and-validation-of-the-dutch-language-version-for-ankle-fractures
#12
A Siebe de Boer, Roderik J C Tjioe, Fleur Van der Sijde, Duncan E Meuffels, Pieter T den Hoed, Cornelis H Van der Vlies, Wim E Tuinebreijer, Michael H J Verhofstad, Esther M M Van Lieshout
OBJECTIVES: The American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale is among the most commonly used instruments for measuring outcome of treatment in patients who sustained a complex ankle or hindfoot injury. It consists of a patient-reported and a physician-reported part. A validated, Dutch version of this instrument is currently not available. The aim of this study was to translate the instrument into Dutch and to determine the measurement properties of the AOFAS Ankle-Hindfoot Scale Dutch language version (DLV) in patients with a unilateral ankle fracture...
August 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/28770007/cross-sectional-associations-between-variations-in-ankle-shape-by-statistical-shape-modeling-injury-history-and-race-the-johnston-county-osteoarthritis-project
#13
Amanda E Nelson, Yvonne M Golightly, Shahmeer Lateef, Jordan B Renner, Joanne M Jordan, Richard M Aspden, Howard Hillstrom, Jennifer S Gregory
BACKGROUND: Injury is an important risk factor for osteoarthritis (OA), a highly prevalent and disabling joint disease. Joint shape is linked to OA, but the interplay of injury and joint shape and their combined role in OA, particularly at the ankle, is not well known. Therefore, we explored cross-sectional associations between ankle shape and injury in a large community-based cohort. METHODS: Ankles without radiographic OA were selected from the current data collection of the Johnston County OA Project...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28766080/trajectories-in-quality-of-life-of-patients-with-a-fracture-of-the-distal-radius-or-ankle-using-latent-class-analysis
#14
M A C Van Son, J De Vries, W Zijlstra, J A Roukema, T Gosens, M H J Verhofstad, B L Den Oudsten
PURPOSE: This prospective study aimed to identify the different trajectories of quality of life (QOL) in patients with distal radius fractures (DRF) and ankle fractures (AF). Secondly, it was examined if subgroups could be characterized by sociodemographic, clinical, and psychological variables. METHODS: Patients (n = 543) completed the World Health Organization Quality of Life assessment instrument-Bref (WHOQOL-Bref), the pain, coping, and cognitions questionnaire, NEO-five factor inventory (neuroticism and extraversion), and the state-trait anxiety inventory (short version) a few days after fracture (i...
August 1, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28765779/effects-of-folic-acid-supplementation-on-serum-homocysteine-levels-lipid-profiles-and-vascular-parameters-in-post-menopausal-korean-women-with-type-2-diabetes-mellitus
#15
Aswathy Vijayakumar, Eun-Kyung Kim, Hyesook Kim, Young Ju Choi, Kap Bum Huh, Namsoo Chang
BACKGROUND/OBJECTIVES: Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. Homocysteine has been recently identified as a predictor of cardiovascular disease-related complications in diabetes. We investigated whether or not supplementation with folic acid tablets can lower homocysteine levels and improve parameters related with vascular complications. SUBJECTS/METHODS: We conducted a non-randomized 8-week trial involving postmenopausal diabetic women (n = 25) supplemented with 800 µg of folic acid (400 µg twice a day) daily...
August 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28765054/validity-and-reliability-of-turkish-version-of-olerud-molander-ankle-score-in-patients-with-malleolar-fracture
#16
Nihal Büker, Raziye Şavkın, Oğuzhan Gökalp, Nusret Ök
The present study was planned to translate and culturally adapt the Olerud-Molander Ankle Score (OMAS) and assess the validity and reliability of the Turkish translation of the OMAS in patients with surgically treated malleolar fracture. The OMAS was adapted for use in Turkish by first translating it and then back-translating it in accordance with published guidelines. The final Turkish version of the OMAS was administered to 91 patients participating in the present study. The OMAS questionnaire was repeated 7 days later to assess test-retest reliability...
July 29, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28762149/corr-insights-%C3%A2-are-there-differences-in-gait-mechanics-in-patients-with-a-fixed-versus-mobile-bearing-total-ankle-arthroplasty-a-randomized-trial
#17
Xavier M Crevoisier
No abstract text is available yet for this article.
July 31, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28761698/sports-injuries-and-illnesses-in-first-year-physical-education-teacher-education-students
#18
Anne-Marie van Beijsterveldt, Angelo Richardson, Benjamin Clarsen, Janine Stubbe
BACKGROUND/AIM: We aimed to investigate the magnitude and characteristics of injuries and illnesses in Dutch physical education teacher education (PETE) students. METHODS: During the first 21 weeks of the academic year, 245 first-year students registered their health problems online using the Oslo Sports Trauma Research Centre (OSTRC) Questionnaire on Health Problems. RESULTS: A total of 276 injuries, 140 illnesses and 69 unclassified health problems were reported...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28759901/subsequent-injuries-and-early-recurrent-diagnoses-in-elite-rugby-union-players
#19
Sean Williams, Grant Trewartha, Simon Kemp, Matthew J Cross, John H M Brooks, Colin W Fuller, Aileen E Taylor, Keith A Stokes
An eight-season (2005/06-2012/13) prospective cohort design was used to record time-loss injuries in 15 English Premiership teams. Data pertaining to a total of 1 556 players and 9 597 injuries (8 180 subsequent) were included in the analysis. Injuries subsequent to an index injury were classified as (1) New: different site; (2) Local: same site (and different type); or (3) Recurrent: same site and type. The severity of subsequent injuries (days missed) was compared with their related index injury. The proportions of early (<2 months), late (2-12 months) and delayed (>12 months) subsequent injuries were compared across injury classifications and diagnosis groupings...
July 31, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28758444/response-to-letter-regarding-anterior-heterotopic-ossification-at-the-talar-neck-after-total-ankle-arthroplasty
#20
Sang-Hun Lee
No abstract text is available yet for this article.
August 2017: Foot & Ankle International
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