Frank X Guyette, Mazen Zenati, Darrell J Triulzi, Mark H Yazer, Hunter Skroczky, Barbara J Early, Peter W Adams, Joshua B Brown, Louis Alarcon, Matthew D Neal, Raquel M Forsythe, Brian S Zuckerbraun, Andrew B Peitzman, Timothy R Billiar, Jason L Sperry
INTRODUCTION: Low titer group O whole blood (LTOWB) resuscitation is increasingly common in both military and civilian settings. Data regarding the safety and efficacy of prehospital LTOWB remain limited. METHODS: We performed a single-center, prospective, cluster randomized, prehospital through in-hospital whole blood pilot trial for injured air medical patients. We compared standard prehospital air medical care including red cell transfusion and crystalloids followed by in-hospital component transfusion to prehospital and in-hospital LTOWB resuscitation...
May 1, 2022: Journal of Trauma and Acute Care Surgery