Angela C Rieger, Bryon A Tompkins, Makoto Natsumeda, Victoria Florea, Monisha N Banerjee, Jose Rodriguez, Marcos Rosado, Valeria Porras, Krystalenia Valasaki, Lauro M Takeuchi, Kevin Collon, Sohil Desai, Michael A Bellio, Aisha Khan, Nilesh D Kashikar, Ana Marie Landin, Darrell V Hardin, Daniel A Rodriguez, Wayne Balkan, Joshua M Hare, Ivonne Hernandez Schulman
BACKGROUND: Left ventricular hypertrophy and heart failure with preserved ejection fraction (HFpEF) are primary manifestations of the cardiorenal syndrome in patients with chronic kidney disease (CKD). Therapies that improve morbidity and mortality in HFpEF are lacking. Cell-based therapies promote cardiac repair in ischemic and non-ischemic cardiomyopathies. We hypothesized that cell-based therapy ameliorates CKD-induced HFpEF. METHODS AND RESULTS: Yorkshire pigs (n = 26) underwent 5/6 embolization-mediated nephrectomy...
March 3, 2022: Stem Cells Translational Medicine