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https://www.readbyqxmd.com/read/29157961/improvement-of-intestinal-absorption-of-curcumin-by-cyclodextrins-and-the-mechanisms-underlying-absorption-enhancement
#1
Xinpeng Li, Sachiyo Uehara, Kasirawat Sawangrat, Masaki Morishita, Kosuke Kusamori, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
Curcumin is known to possess a wide range of pharmacological activities for the treatment of chronic or inflammatory diseases, Alzheimer's disease, and various cancers. However, the therapeutic efficacy of curcumin is restricted by its poor bioavailability after oral administration. In this study, the effects of various cyclodextrins on the intestinal absorption of curcumin were evaluated in rat intestine by an in situ closed-loop method. Among the tested cyclodextrins, 50 mM α-cyclodextrin significantly enhanced the absorption of curcumin without inducing any intestinal toxicity...
November 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29145422/missense-mutation-at-cldn8-associated-with-a-high-plasma-interferon-gamma-inducible-protein-10-level-in-methadone-maintained-patients-with-urine-test-positive-for-morphine
#2
Tung-Hsia Liu, Ren-Hua Chung, Sheng-Chang Wang, Chiu-Ping Fang, Hsiao-Hui Tsou, Chia-Lung Shih, Hsiang-Wei Kuo, Yun Wang, Yu-Li Liu
We previously reported a high plasma chemokine interferon gamma-inducible protein 10 (IP-10) level and prolonged electrocardiography QT-interval in methadone maintenance treatment (MMT) patients with HIV or HCV infection. The purpose of this study was to evaluate the genetic association of high plasma IP-10 level in the MMT patients. The gene-based and pathway-based association analyses were conducted using a genome-wide association study dataset in 344 MMT patients for identifying genes and pathways associated with plasma IP-10 level...
2017: PloS One
https://www.readbyqxmd.com/read/29134439/treatment-related-survival-associations-of-claudin-2-expression-in-fibroblasts-of-colorectal-cancer
#3
Artur Mezheyeuski, Carina Strell, Ina Hrynchyk, Tormod Kyrre Guren, Anca Dragomir, Tatyana Doroshenko, Oksana Pashkova, Julia Gorgun, Kseniya Ruksha, Per Pfeiffer, Elin H Kure, Halfdan Sorbye, David Edler, Anna Martling, Bengt Glimelius, Arne Östman, Anna Portyanko
Claudin-2 is a trans-membrane protein-component of tight junctions in epithelial cells. Elevated claudin-2 expression has been reported in colorectal cancer (CRC). The aim of this study was to investigate the expression patterns of claudin-2 in human CRC samples and analyze its association with clinical characteristics and treatment outcome. TMAs of primary tumors from two cohorts of metastatic CRC (mCRC) were used. Claudin-2 IHC staining was evaluated in a semi-quantitative manner in different regions and cell types...
November 13, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29128906/toll-like-receptor-3-mediates-hiv-1-induced-interleukin-6-expression-in-the-human-brain-endothelium-via-tak1-and-jnk-pathways-implications-for-viral-neuropathogenesis
#4
Biju Bhargavan, Georgette D Kanmogne
HIV-1-associated neurocognitive disorders (HAND) is associated with blood-brain-barrier (BBB) inflammation, and inflammation involves toll-like receptors (TLRs) signaling. It is not known whether primary human brain microvascular endothelial cells (HBMEC), the major BBB component, express TLRs or whether TLRs are involved in BBB dysfunction and HAND. We demonstrate that HBMEC express TLR3, 4, 5, 7, 9, and 10, and TLR3 was the most abundant. HIV-1 and TLR3 activation increased endothelial TLR3 transcription and expression...
November 11, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29123511/a-high-grain-diet-dynamically-shifted-the-composition-of-mucosa-associated-microbiota-and-induced-mucosal-injuries-in-the-colon-of-sheep
#5
Yue Wang, Lei Xu, Junhua Liu, Weiyun Zhu, Shengyong Mao
This study investigated the dynamic shifts in mucosa-associated microbiota composition and mucosal morphology in the colon of sheep fed a high grain (HG) diet. A total of 20 male sheep were randomly assigned to four groups (n = 5 for each). The sheep in first group received hay diet. The animals in other 3 groups were fed an HG diet for 7 (HG7), 14 (HG14), or 28 (HG28) days, respectively. Colonic digesta samples were collected to determine the pH and the concentrations of volatile fatty acid (VFA) and lactate...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29121970/endothelial-%C3%AE-6%C3%AE-4-integrin-protects-during-experimental-autoimmune-encephalomyelitis-induced-neuroinflammation-by-maintaining-vascular-integrity-and-tight-junction-protein-expression
#6
Jennifer V Welser, Sebok K Halder, Ravi Kant, Amin Boroujerdi, Richard Milner
BACKGROUND: Extracellular matrix (ECM) proteins play critical functions regulating vascular formation and function. Laminin is a major component of the vascular basal lamina, and transgenic mice deficient in astrocyte or pericyte laminin show defective blood-brain barrier (BBB) integrity, indicating an important instructive role for laminin in cerebral blood vessels. As previous work shows that in the normal brain, vascular expression of the laminin receptor α6β4 integrin is predominantly restricted to arterioles, but induced on all vessels during neuroinflammation, it is important to define the role of this integrin in the maintenance of BBB integrity...
November 9, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29116019/cldn6-promotes-chemoresistance-through-gstp1-in-human-breast-cancer
#7
Minlan Yang, Yanru Li, Xiangfeng Shen, Yang Ruan, Yan Lu, Xiangshu Jin, Peiye Song, Yantong Guo, Xiaoli Zhang, Huinan Qu, Yijia Shao, Chengshi Quan
BACKGROUND: Claudin-6 (CLDN6), a member of CLDN family and a key component of tight junction, has been reported to function as a tumor suppressor in breast cancer. However, whether CLDN6 plays any role in breast cancer chemoresistance remains unclear. In this study, we investigated the role of CLDN6 in the acquisition of chemoresistance in breast cancer cells. METHODS: We manipulated the expression of CLDN6 in MCF-7 and MCF-7/MDR cells with lv-CLDN6 and CLDN6-shRNA and investigated whether CLDN6 manipulation lead to different susceptibilities to several chemotherapeutic agents in these cells...
November 7, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29115856/lps-induced-acute-lung-injury-involves-the-nf-%C3%AE%C2%BAb-mediated-downregulation-of-sox18
#8
Christine M Gross, Manuela Kellner, Ting Wang, Qing Lu, Xutong Sun, Evgeny A Zemskov, Satish Noonepalle, Archana Kangath, Sanjiv Kumar, Manuel Gonzalez-Garay, Ankit A Desai, Saurabh Aggarwal, Boris Gorshkov, Christina Klinger, Alexander D Verin, John D Catravas, Jeffrey R Jacobson, Jason X-J Yuan, Ruslan Rafikov, Joe G N Garcia, Stephen M Black
One of the early events in the progression of lipopolysaccharide (LPS)-mediated acute lung injury (ALI) in mice is the disruption of the pulmonary endothelial barrier resulting in lung edema. However, the molecular mechanisms by which the endothelial barrier becomes compromised remain unresolved. The SRY-related High Mobility Group box (Sox) group-F family member, Sox18, is a barrier- protective protein through its ability to increase the expression of the tight junction protein, Claudin-5. Thus, the purpose of this study was to determine if down-regulation of the Sox18-Claudin-5 axis plays a role in the pulmonary endothelial barrier disruption associated with LPS exposure...
November 8, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29115705/co-culturing-porcine-normal-urothelial-cells-urinary-bladder-fibroblasts-and-smooth-muscle-cells-for-tissue-engineering-research
#9
Daša Zupančič, Katjuša Mrak Poljšak, Mateja Erdani Kreft
New strategies for culturing and co-culturing of the main types of urinary bladder cells are essential for successful establishment of biomimetic in vitro models, which could be applied for research into, and management of, diverse urological disorders. Porcine normal urothelial cells are available in nearly unlimited amounts and have many properties equivalent to human urothelial cells. In the present study, we established normal differentiated porcine urothelial cells in co-cultures with porcine urinary bladder normal fibroblasts and/or smooth muscle cells...
November 8, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29112624/effect-of-early-and-adult-life-socioeconomic-circumstances-on-physical-inactivity
#10
Boris Cheval, Stefan Sieber, Idris Guessous, Dan Orsholits, Delphine S Courvoisier, Matthias Kliegel, Silvia Stringhini, Stephan P Swinnen, Claudine Burton-Jeangros, Stéphane Cullati, Matthieu P Boisgontier
PURPOSE: To investigate the associations between early- and adult-life socioeconomic circumstances and physical inactivity (level and evolution) in ageing using large-scale longitudinal data. METHODS: This study used the Survey of Health Ageing and Retirement in Europe (SHARE), a 10-year population-based cohort study with repeated measurements in 5 waves, every 2 years between 2004 and 2013. Self-reported physical inactivity (waves 1, 2, 4, and 5), household income (waves 1, 2, 4, and 5), educational attainment (wave of the first measurement occasion), and early-life SEC (wave 3) were collected in 22,846 individuals aged 50 to 95 years...
November 6, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29107696/the-potential-mechanism-for-hydroxysafflor-yellow-a-attenuating-blood-brain-barrier-dysfunction-via-tight-junction-signaling-pathways-excavated-by-an-integrated-serial-affinity-chromatography-and-shotgun-proteomics-analysis-approach
#11
Yanni Lv, Longsheng Fu
Our previous studies elucidated that hydroxysafflor yellow A (HSYA) exerted anti-inflammatory effects against ischemia stroke by inhibiting TLR4 pathway-mediated signaling transduction. However, only several targets were verified in that limited work. The integrated method of serial affinity chromatography (SAC) and shotgun proteomics analysis (SPA) might be an alternative approach for exploring a potential therapeutic role. SAC was induced to extract specific binding proteins in the brain tissue of 2 h of ischemia stroke mice via HSYA affinity matrices...
October 28, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29104935/modeling-group-b-streptococcus-and-blood-brain-barrier-interaction-by-using-induced-pluripotent-stem-cell-derived-brain-endothelial-cells
#12
Brandon J Kim, Olivia B Bee, Maura A McDonagh, Matthew J Stebbins, Sean P Palecek, Kelly S Doran, Eric V Shusta
Bacterial meningitis is a serious infection of the central nervous system (CNS) that occurs after bacteria interact with and penetrate the blood-brain barrier (BBB). The BBB is comprised of highly specialized brain microvascular endothelial cells (BMECs) that function to separate the circulation from the CNS and act as a formidable barrier for toxins and pathogens. Certain bacteria, such as Streptococcus agalactiae (group B Streptococcus [GBS]), possess the ability to interact with and penetrate the BBB to cause meningitis...
November 2017: MSphere
https://www.readbyqxmd.com/read/29100986/dietary-threonine-deficiency-depressed-the-disease-resistance-immune-and-physical-barriers-in-the-gills-of-juvenile-grass-carp-ctenopharyngodon-idella-under-infection-of-flavobacterium-columnare
#13
Yu-Wen Dong, Lin Feng, Wei-Dan Jiang, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Xiao-Qiu Zhou
This study was conducted to investigate the effects of dietary threonine on the disease resistance, gill immune and physical barriers function of juvenile grass carp (Ctenopharyngodon idella). A total of 1080 juveniles were fed six iso-nitrogenous diets containing graded levels of threonine (3.99-21.66 g kg(-1) diet) for 8 weeks, and then challenged with Flavobacterium columnare. Results showed that threonine deficiency (3.99 g kg(-1) diet): (1) increased the gill rot morbidity after exposure to F. columnare; (2) attenuated the gill immune barrier function by decreasing antimicrobial substances production, up-regulating the mRNA levels of pro-inflammatory cytokines (except IL-12p40), and down-regulating the anti-inflammatory cytokines partly due to the modulation of NF-κB and TOR signaling...
October 31, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29100486/an-ecv304-monoculture-model-for-permeability-assessment-of-blood-brain-barrier
#14
Shu Yang, Hong Jin, Zhigang Zhao
OBJECTIVE: ECV304/C6 co-culture model is a widely used tool for BBB studies. However, cell source may influence the establishment of co-culture model and some C6 cells could damage the barrier integrity. Here, we established an ECV304 monoculture model and evaluated it in the respect of tightness, tight junction proteins and discriminative brain penetration. METHODS: The tightness of ECV304 cell layers was evaluated by the measurement of permeability to hydrophilic marker Lucifer yellow...
November 3, 2017: Neurological Research
https://www.readbyqxmd.com/read/29095204/improvement-of-blood-brain-barrier-integrity-in-traumatic-brain-injury-and-hemorrhagic-shock-following-treatment-with-valproic-acid-and-fresh-frozen-plasma
#15
Vahagn C Nikolian, Simone E Dekker, Ted Bambakidis, Gerald A Higgins, Isabel S Dennahy, Patrick E Georgoff, Aaron M Williams, Anuska V Andjelkovic, Hasan B Alam
OBJECTIVE: Combined traumatic brain injury and hemorrhagic shock are highly lethal. Following injuries, the integrity of the blood-brain barrier can be impaired, contributing to secondary brain insults. The status of the blood-brain barrier represents a potential factor impacting long-term neurologic outcomes in combined injuries. Treatment strategies involving plasma-based resuscitation and valproic acid therapy have shown efficacy in this setting. We hypothesize that a component of this beneficial effect is related to blood-brain barrier preservation...
October 31, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29093286/protection-of-tong-qiao-huo-xue-decoction-against-cerebral-ischemic-injury-through-reduction-blood-brain-barrier-permeability
#16
Lili Li, Ning Wang, Qizhong Jin, Qian Wu, Yafang Liu, Yan Wang
Tong-Qiao-Huo-Xue Decoction (TQHXD) is a classical prescription in traditional Chinese medicine treating blood stagnation in the head and facial channels, especially cerebral ischemia. We investigate the effect of TQHXD on the expressions of related proteins of the blood-brain barrier (BBB) and analysis of constituents in the cerebrospinal fluid (CSF) on cerebral ischemic model rats. Here, we demonstrate that TQHXD protected the hippocampus neurons, reduced the opening of tight junction (TJ) and decreased the permeability of BBB by up-regulating ZO-1, occludin, claudin-5 expressions, down-regulating aquaporin-4 (AQP-4) and matrix metalloproteinase-9 (MMP-9) expressions...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29073573/exposure-to-traffic-generated-air-pollutants-mediates-alterations-in-brain-microvascular-integrity-in-wildtype-mice-on-a-high-fat-diet
#17
Usa Suwannasual, JoAnn Lucero, Jacob D McDonald, Amie K Lund
Air pollution-exposure is associated with detrimental outcomes in the central nervous system (CNS) such as cerebrovascular disorders, including stroke, and neurodegenerative diseases. While the mechanisms of these CNS-related outcomes involved have not been fully elucidated, exposure to traffic-generated air pollutants has been associated with altered blood brain barrier (BBB) integrity and permeability. The current study investigated whether inhalation exposure to mixed vehicle emissions (MVE) alters cerebral microvascular integrity in healthy 3 mo old C57BL/6 mice, as well as whether exposure-mediated effects were exacerbated by a high-fat (HF) vs...
October 23, 2017: Environmental Research
https://www.readbyqxmd.com/read/29071269/iodine-125-brachytherapy-for-uveal-melanoma-a-systematic-review-of-radiation-dose
#18
REVIEW
Jose J Echegaray, Nikolaos E Bechrakis, Nakul Singh, Claudine Bellerive, Arun D Singh
AIM: To investigate whether lower radiation doses may yield similar outcome measures to those from the COMS trial. METHODS: A literature review of English language articles was performed using the PubMed database of the U.S. National Library of Medicine and the Cochrane Central Register of Controlled Trials using the following keywords: uveal melanoma, choroidal melanoma, primary uveal malignant melanoma, iodine-125 brachytherapy, local recurrence, local treatment failure, and local tumor control...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29069891/additive-effects-of-rebamipide-plus-proton-pump-inhibitors-on-the-expression-of-tight-junction-proteins-in-a-rat-model-of-gastro-esophageal-reflux-disease
#19
Tae-Geun Gweon, Jong-Hyung Park, Byung-Wook Kim, Yang Kyu Choi, Joon Sung Kim, Sung Min Park, Chang Whan Kim, Hyung-Gil Kim, Jun-Won Chung
Background/Aims: The aim of this study was to investigate the effects of rebamipide on tight junction proteins in the esophageal mucosa in a rat model of gastroesophageal reflux disease (GERD). Methods: GERD was created in rats by tying the proximal stomach. The rats were divided into a control group, a proton pump inhibitor (PPI) group, and a PPI plus rebamipide (PPI+R) group. Pantoprazole (5 mg/kg) was administered intraperitoneally to the PPI and PPI+R groups...
October 27, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29063414/trends-in-the-incidence-of-dementia-design-and-methods-in-the-alzheimer-cohorts-consortium
#20
Lori B Chibnik, Frank J Wolters, Kristoffer Bäckman, Alexa Beiser, Claudine Berr, Joshua C Bis, Eric Boerwinkle, Daniel Bos, Carol Brayne, Jean-Francois Dartigues, Sirwan K L Darweesh, Stephanie Debette, Kendra L Davis-Plourde, Carole Dufouil, Myriam Fornage, Leslie Grasset, Vilmundur Gudnason, Christoforos Hadjichrysanthou, Catherine Helmer, M Arfan Ikram, M Kamran Ikram, Silke Kern, Lewis H Kuller, Lenore Launer, Oscar L Lopez, Fiona Matthews, Osorio Meirelles, Thomas Mosley, Alison Ower, Bruce M Psaty, Claudia L Satizabal, Sudha Seshadri, Ingmar Skoog, Blossom C M Stephan, Christophe Tzourio, Reem Waziry, Mei Mei Wong, Anna Zettergren, Albert Hofman
Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard to the impact of gender and education with underlying causes of a presumed declining trend remaining largely unidentified. The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since 1990...
October 23, 2017: European Journal of Epidemiology
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