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Naringin AND glycation

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https://www.readbyqxmd.com/read/27739344/inhibition-of-periodontitis-induction-using-a-stimuli-responsive-hydrogel-carrying-naringin
#1
Po-Chun Chang, Yi-Chi Chao, Meng-Hsuan Hsiao, Hao-Syun Chou, Yi-Han Jheng, Xin-Hong Yu, Ning Lee, Connie Yang, Dean-Mo Liu
BACKGROUND: Developing a drug carrier with favorable handling characteristics that can respond to environmental changes following inflammation, such as pH changes, may be beneficial for treating periodontitis. This study aimed to investigate the preclinical feasibility of using naringin, a naturally derived polymethoxylated flavonoid compound with anti-inflammatory properties, to inhibit periodontitis induction via a thermo-gelling and pH-responsive injectable hydrogel. METHODS: The hydrogel was made of amphipathic carboxymethyl-hexanoyl chitosan (CHC), beta glycerol-phosphate (β-GP), and glycerol, and the thermo-gelling and pH-responsive characteristics of the hydrogel as well as the cell viability after treatment with the hydrogel containing naringin were evaluated in vitro...
October 14, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/26461390/polyphenols-protect-against-protein-glycoxidation
#2
Izabela Sadowska-Bartosz, Sabina Galiniak, Grzegorz Bartosz
Glycoxidation belongs to posttranslational protein modifications which underlie pathological sequelae of diabetes and other diseases, and contribute to aging. Search for efficient inhibitors of glycoxidation is therefore of considerable importance. We studied the effect of various polyphenols on the glycoxidation of bovine serum albumin (90 uM) incubated in vitro with glucose, fructose or ribose (100mM) for 6 days in 0.1M phosphate buffer, pH 7.4. Polyphenols have multiple biological actions including antioxidant activity and chelation of transition metal ions...
October 2014: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26147673/preconditioning-l6-muscle-cells-with-naringin-ameliorates-oxidative-stress-and-increases-glucose-uptake
#3
R Dhanya, K B Arun, V M Nisha, H P Syama, P Nisha, T R Santhosh Kumar, P Jayamurthy
Enhanced oxidative stress contributes to pathological changes in diabetes and its complications. Thus, strategies to reduce oxidative stress may alleviate these pathogenic processes. Herein, we have investigated Naringin mediated regulation of glutathione (GSH) & intracellular free radical levels and modulation of glucose uptake under oxidative stress in L6 cell lines. The results from the study demonstrated a marked decrease in glutathione with a subsequent increase in free radical levels, which was reversed by the pretreatment of Naringin...
2015: PloS One
https://www.readbyqxmd.com/read/26108947/evaluation-of-potential-flavonoid-inhibitors-of-glyoxalase-i-based-on-virtual-screening-and-in-vitro-studies
#4
Aarti Yadav, Rajnish Kumar, Aditya Sunkaria, Nitin Singhal, Manoj Kumar, Rajat Sandhir
Glyoxalase-I (GLO-I) is a component of the ubiquitous detoxification system involved in the conversion of methylglyoxal (MG) to d-lactate in the glycolytic pathway. MG toxicity arises from its ability to form advanced glycation end products. GLO-I has been reported to be frequently overexpressed in various types of cancer cells. In this study, we performed structure-based virtual screening of focused flavonoids commercial library to identify potential and specific inhibitors of GLO-I. The compounds were ranked based on Glide extra precision docking score and five hits (curcumin, quercetin, morin, naringin and silibinin) were selected on the basis of their interaction with active site amino acid residues of GLO-I...
May 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/24880026/naringin-a-flavanone-glycoside-promotes-angiogenesis-and-inhibits-endothelial-apoptosis-through-modulation-of-inflammatory-and-growth-factor-expression-in-diabetic-foot-ulcer-in-rats
#5
Amit D Kandhare, Pinaki Ghosh, Subhash L Bodhankar
Chronic, unhealed diabetic foot ulcer (DFU) is one of the most severe complications of diabetes mellitus (DM). Naringin, a flavanone glycoside antioxidant, was reported to have antidiabetic and anti-apoptotic properties. In the present study DM was induced experimentally by streptozotocin (STZ, 55 mg/kg, i.p.). In surgically introduced wounds on the dorsal surface of the hind paw of rats, the healing potential of naringin was investigated. Rats were treated with naringin (20, 40 and 80 mg/kg, p.o.), insulin (10 IU/kg, s...
August 5, 2014: Chemico-biological Interactions
https://www.readbyqxmd.com/read/24747646/kinetics-of-glycoxidation-of-bovine-serum-albumin-by-methylglyoxal-and-glyoxal-and-its-prevention-by-various-compounds
#6
Izabela Sadowska-Bartosz, Sabina Galiniak, Grzegorz Bartosz
The aim of this study was to compare several methods for measurement of bovine serum albumin (BSA) modification by glycoxidation with reactive dicarbonyl compounds (methylglyoxal--MGO and glyoxal--GO), for studies of the kinetics of this process and to compare the effects of 19 selected compounds on BSA glycation by the aldehydes. The results confirm the higher reactivity of MGO with respect to GO and point to the usefulness of AGE, dityrosine and N'-formylkynurenine fluorescence for monitoring glycation and evaluation of protection against glycation...
2014: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/21506932/effects-of-antioxidant-polyphenols-on-tnf-alpha-related-diseases
#7
REVIEW
Kiichiro Kawaguchi, Tsukasa Matsumoto, Yoshio Kumazawa
Oxidative stress and inflammatory responses sustained for a long period of time cause many diseases. A proinflammatory cytokine, tumor necrosis factor α (TNF-α), plays a pivotal role in the pathogenesis of chronic and auto-immune diseases. The present review, supplemented by hitherto unpublished data of the authors and their coworkers, shows that the intake of polyphenols contained in natural sources, such as hydroxytyrosol, tyrosol, oleuropein (olives), naringin and hesperidin (Citrus fruits), resveratrol, procyanidins or oligomeric procyanidin (grapes or grape seed extracts), (-)-epigallocatechin gallate (green tea) and quercetin (grapes, green tea) etc...
2011: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/19489629/low-density-lipoprotein-ldl-bound-flavonoids-increase-the-resistance-of-ldl-to-oxidation-and-glycation-under-pathophysiological-concentrations-of-glucose-in-vitro
#8
Chi-Hao Wu, Jer-An Lin, Wen-Ching Hsieh, Gow-Chin Yen
The higher susceptibility of low-density lipoprotein (LDL) to oxidation and glycation in diabetes has been shown to be related to poor glycemic control. The aim of this study was to determine whether LDL-bound flavonoids attenuate high-glucose (HG)-mediated LDL oxidation and glycation. For this purpose, human plasma was preincubated with individual flavonoids for 3 h, followed by sequential ultracentrifugation and extensive dialysis to remove unbound flavonoid samples. Enriched LDL was subsequently isolated and challenged for its resistance to oxidation and glycation...
June 10, 2009: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/18344197/combined-treatment-with-naringin-and-vitamin-c-ameliorates-streptozotocin-induced-diabetes-in-male-wistar-rats
#9
V R Punithavathi, R Anuthama, P Stanely Mainzen Prince
Diet and nutrition have substantial impact on reducing the incidence of diabetes mellitus, where oxidative stress is an important etiopathological factor. The combined protective role of low dose of naringin (15 mg kg(-1)) and vitamin C (25 mg kg(-1)) and high dose of naringin (30 mg kg(-1)) and vitamin C (50 mg kg(-1)) on streptozotocin (STZ)-induced toxicity was studied in male Wistar rats. To induce type II diabetes mellitus, rats were injected with STZ intraperitoneally at a dose of 45 mg kg(-1) body weight...
August 2008: Journal of Applied Toxicology: JAT
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