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https://www.readbyqxmd.com/read/28945044/-effect-of-qishen-yiqi-droplet-on-adenylate-contents-in-myocardium-of-cor-pulmonale-rats
#1
Shi-Han Geng, Qiu-Yue Shan, Meng-Xi Xu, Yi-Dan Zhang, Li-Li Song, Ning Hou, Wen Zhang, Mi-Xia Zhang, Peng-Wei Zhuang, Yan-Jun Zhang
Cor pulmonale rat models were induced by a single intraperitoneal injection of monocrotaline(MCT), and the sham group received a single intraperitioneal injection of normal saline. After the model rats received intragastric administration of Qishen Yiqi droplet(QS) for 6 weeks, the contents of adenylate(ATP, ADP and AMP) in right myocardial tissues were measured by HPLC, and then the metabolism changes in myocardium of cor pulmonale rats with QS were investigated. The results showed that ATP, ADP, and AMP were well separated, with a good linearity within a certain range of concentration; and the recovery rates were within the range of 90%-108%...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944828/protective-effects-of-gv1001-on-myocardial-ischemia%C3%A2-reperfusion-injury
#2
Ji-Eun Chang, Hyun Jun Kim, Sanghoon Jheon, Cheong Lim
The potential cardioprotective effects of the novel vaccine peptide GV1001 were evaluated in myocardial ischemia‑reperfusion injury induced rat models. GV1001 is a human telomerase reverse transcriptase derived peptide, which has been reported to possess both anti‑tumor and anti‑inflammatory effects. The normal saline (control group) and various concentrations (0.001‑10 mg/kg) of GV1001 were administered directly to the right ventricle anterior wall before induction of ischemia. The was induced by Tightening the snare around the left anterior descending coronary artery for 40 min, before releasing the snare for 10 min induced the myocardial ischemia‑reperfusion injury and was conducted in Sprague‑Dawley rats...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28943754/pinus-densiflora-bark-extract-prevents-selenite-induced-cataract-formation-in-the-lens-of-sprague-dawley-rat-pups
#3
Jun Kim, Se-Young Choung
PURPOSE: Rat pups treated with sodium selenite are typically used as an in vivo model to mimic age-related nuclear cataract. Reactive oxygen species (ROS) production, lipid peroxidation, reduction of antioxidant enzymes, crystalline proteolysis, and apoptosis are considered factors that contribute to pathogenesis of age-related nuclear cataract. In the present study, we investigated whether Pinus densiflora bark extract has potential to prevent cataract formation and elucidated the underlying mechanism...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28943226/influences-of-red-blood-cell-and-platelet-counts-on-the-distribution-and-elimination-of-crystalloid-fluid
#4
Robert G Hahn
BACKGROUND AND OBJECTIVE: A high number of blood cells increases the viscosity of the blood. The present study explored whether variations in blood cell counts are relevant to the distribution and elimination of infused crystalloid fluid. MATERIALS AND METHODS: On three different occasions, 10 healthy male volunteers received an intravenous infusion of 25mL/kg of Ringer's acetate, Ringer's lactate, and isotonic saline over 30min. Blood hemoglobin and urinary excretion were monitored for 4h and used as input in a two-volume kinetic model, using nonlinear mixed effects software...
August 3, 2017: Medicina
https://www.readbyqxmd.com/read/28940582/randomized-controlled-trial-of-steroid-soaked-absorbable-calcium-alginate-nasal-packing-following-endoscopic-sinus-surgery
#5
Chi Sang Hwang, Salma Saud Al Sharhan, Bo Ra Kim, Soo In Kim, Jin Woong Kim, Hyung-Ju Cho, Joo-Heon Yoon, Chang-Hoon Kim
OBJECTIVES/HYPOTHESIS: To evaluate the potential efficacy of steroid-soaked, absorbable calcium alginate nasal packing following endoscopic sinus surgery. STUDY DESIGN: Prospective, randomized, single-blinded, placebo-controlled trial. METHODS: Twenty-two patients (44 nostrils) who had chronic rhinosinusitis with polyps underwent bilateral endoscopic sinus surgery. Only those with an intersinus difference in Lund-Mackay severity score of 1 or less were included...
September 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28937043/inhibition-of-cd38-cyclic-adp-ribose-pathway-protects-rats-against-ropivacaine-induced-convulsion
#6
Yu Zou, Xin He, Qian-Yi Peng, Qu-Lian Guo
BACKGROUND: The CD38/cyclic ADP-ribose (cADPR) pathway plays a role in various central nervous system diseases and in morphine tolerance, but its role in local anesthetic intoxication is unknown. The aim of this study was to determine the role of the CD38/cADPR pathway in ropivacaine-induced convulsion. METHODS: Forty male Sprague-Dawley rats were randomly divided into five groups (n = 8 per group): sham group, ropivacaine group, ropivacaine+8-Br-cADPR (5 nmol) group, ropivacaine+8-Br-cADPR (10 nmol) group, and ropivacaine+8-Br-cADPR (20 nmol) group (no rats died)...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28937034/effect-of-cordyceps-sinensis-on-the-treatment-of-experimental-autoimmune-encephalomyelitis-a-pilot-study-on-mice-model
#7
Shan-Shan Zhong, Ya-Juan Xiang, Pen-Ju Liu, Yang He, Ting-Ting Yang, Yang-Yang Wang, A Rong, Jun Zhang, Guang-Zhi Liu
BACKGROUND: As a traditional Chinese medicine, Cordyceps sinensis (CS) possesses a variety of immunoregulatory properties. This study aimed to explore the therapeutic potential of CS in a mice model of multiple sclerosis (MS)-experimental autoimmune encephalomyelitis (EAE). METHODS: Female C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein35-55to induce EAE, followed by an instant intragastric feeding with a low dosage of CS (low-CS group, n = 5), high dosage of CS (high-CS group, n = 5), or the same volume of normal saline (control group, n = 5)...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936961/-effects-of-small-rna-interference-targeting-mammalian-target-of-rapamycin-on-paraquat-induced-pulmonary-fibrosis-in-rats
#8
Wenbin Yang, Xiaoqing Zhao, Ran Liang, Da Chen
OBJECTIVE: To investigate the effects of small RNA interference targeting mammalian target of rapamycin (mTOR) expression on paraquat-induced pulmonary fibrosis in rats. METHODS: Human embryonic kidney cells HEK-293 were cultured in vitro. The mTOR small interfering RNA (mTOR-siRNA) expression plasmid transfection lentivirus was constructed, and non-specific sequence plasmid with no homology to mTOR gene was set as the control. Seventy-two healthy male Sprague-Dawley (SD) rats were randomly divided into normal saline (NS) control group, paraquat model group, mTOR unrelated sequence group, and mTOR-siRNA group, with 18 rats in each group...
September 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28936850/-protective-effects-of-schizonepeta-volatile-oil-on-endotoxin-poisoning-induced-by-lipopolysaccharide-in-mice
#9
Tao-Qun Wen, Wen-Tao Sang, Feng Xu, Feng Wang, Nan Zeng
In order to study the protective effects of Schizonepeta volatile oil (Sto)on endotoxin poisoning mice, and the relatively content of each chemical osubstance in Schizonepeta volatile oil was measured using GC-MS. The mare C57BL/6J mice were randomly divided into five groups including the normal group, model group, dexamethasone group (5 mg•kg⁻¹), and Sto (0.226 and 0.452 g•kg⁻¹, respectively) groups. The dexamethasone group was given the drugs once time by intraperitoneal injection on the 5th day, while the other mice were given drugs by oral administration once a day for 5 days...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936148/the-potential-anticoagulant-property-of-caulerpa-lentillifera-crude-extract
#10
Althea R Arenajo, Adrian P Ybañez, Maria Maichol P Ababan, Charlotte E Villajuan, May Rose M Lasam, Chiqui P Young, Julie Lynn A Reyes
BACKGROUND: Anticoagulants have been used in the treatment of several circulatory diseases and thrombotic disorders, and in the blood sampling for hematologic analysis. Sulfated polysaccharides (SP), which have anticoagulant properties, are found in most seaweeds, including Caulerpa spp. OBJECTIVE: The study generally aimed to evaluate the potential anticoagulant property of Caulerpa lentillifera. METHODOLOGY: The whole plant of fresh C. lentillifera was washed thoroughly with distilled water and manually expressed to obtain the extract...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28935953/very-low-density-lipoprotein-of-metabolic-syndrome-modulates-gap-junctions-and-slows-cardiac-conduction
#11
Hsiang-Chun Lee, Chih-Chieh Chen, Wei-Chung Tsai, Hsin-Ting Lin, Yi-Lin Shiao, Sheng-Hsiung Sheu, Bin-Nan Wu, Chu-Huang Chen, Wen-Ter Lai
Very-low-density lipoproteins (VLDL) is a hallmark of metabolic syndrome (MetS) and each manifestation of MetS is related to atrial fibrillation (AF) risks. Slowed atrial conduction is a mechanism of AF in MetS. We hypothesized that VLDL can modulate and reduce atrial gap junctions. VLDLs were separated from normal (Normal-VLDL) and MetS (MetS-VLDL) individuals. VLDLs (15 µg/g) and equivalent volumes of saline (CTL) were injected respectively to C57BL/6 mice for 6 weeks. Electrocardiograms demonstrated that MetS-VLDL induced prolongation of P wave (P = 0...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28934817/aldosterone-to-renin-ratio-as-a-screening-instrument-for-primary-aldosteronism-in-a-middle-aged-population-with-atrial-fibrillation
#12
Georgios Mourtzinis, Ahmad Ebrahimi, Helena Gustafsson, Gudmundur Johannsson, Karin Manhem
Atrial fibrillation seems to be overrepresented among patients with primary aldosteronism. The aim of this study was to determine the usefulness of aldosterone to renin ratio as a screening instrument for primary aldosteronism in an atrial fibrillation population with relatively low cardiovascular risk profile. A total of 149 patients <65 years and with history of AF were screened for primary aldosteronism using aldosterone to renin ratio. Pathologically increased aldosterone to renin ratio (>65 pmol/mIU) was found in 15 participants (10...
September 21, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28933805/perioperative-administration-of-buffered-versus-non-buffered-crystalloid-intravenous-fluid-to-improve-outcomes-following-adult-surgical-procedures
#13
REVIEW
Sohail Bampoe, Peter M Odor, Ahilanandan Dushianthan, Elliott Bennett-Guerrero, Suzie Cro, Tong J Gan, Michael Pw Grocott, Michael Fm James, Michael G Mythen, Catherine Mn O'Malley, Anthony M Roche, Kathy Rowan, Edward Burdett
BACKGROUND: Perioperative fluid strategies influence clinical outcomes following major surgery. Many intravenous fluid preparations are based on simple solutions, such as normal saline, that feature an electrolyte composition that differs from that of physiological plasma. Buffered fluids have a theoretical advantage of containing a substrate that acts to maintain the body's acid-base status - typically a bicarbonate or a bicarbonate precursor such as maleate, gluconate, lactate, or acetate...
September 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28933149/atomic-thick-ptni-nanowires-assembled-on-graphene-for-high-sensitivity-extra-cellular-hydrogen-peroxide-sensors
#14
Yingjun Sun, Mingchuan Luo, Yingnan Qin, Sihao Zhu, Yingjie Li, Nuoyan Xu, Xiangxi Meng, Qiushi Ren, Lei Wang, Shaojun Guo
H2O2 sensors with high sensitivity and selectivity are essential for monitoring normal activities of cells. Inorganic catalytic nanomaterials show the obvious advantage in boosting the sensitivity of H2O2 sensors, however the H2O2 detection limit of reported inorganic catalysts is still limited, which is not suitable for high-sensitivity detection of H2O2 in real cells. Herein, a novel atomic-thick PtNi nanowires (NWs) were synthesized and assembled on reduced oxide graphene (rGO) via ultrasonic self-assembly method to attain PtNi NWs/rGO composite for boost the electroanalysis of H2O2...
September 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28932774/transcriptomic-and-bioinformatics-analysis-of-the-early-time-course-of-the-response-to-prostaglandin-f2-alpha-in-the-bovine-corpus-luteum
#15
Heather Talbott, Xiaoying Hou, Fang Qiu, Pan Zhang, Chittibabu Guda, Fang Yu, Robert A Cushman, Jennifer R Wood, Cheng Wang, Andrea S Cupp, John S Davis
RNA expression analysis was performed on the corpus luteum tissue at five time points after prostaglandin F2 alpha treatment of midcycle cows using an Affymetrix Bovine Gene v1 Array. The normalized linear microarray data was uploaded to the NCBI GEO repository (GSE94069). Subsequent statistical analysis determined differentially expressed transcripts ± 1.5-fold change from saline control with P ≤ 0.05. Gene ontology of differentially expressed transcripts was annotated by DAVID and Panther. Physiological characteristics of the study animals are presented in a figure...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28932498/hemodynamic-effect-of-intravenous-lidocaine-during-aortic-cannulation-in-cardiac-surgery
#16
Ziya Totonchi, Shirin Salajegheh, Mahmoud Reza Mohaghegh, Mehrdad Mesbah Kiaei, Mohammad Shirvani, Masoud Ghorbanlo
BACKGROUND: Dissection of aorta is a rare, but fatal complication of aortic cannulation in cardiac surgery can be caused by the sudden rise in blood pressure and hemodynamic variations. METHODS: In this study, 90 patients aged 18 years or older undergoing cardiac surgery were divided into two equal groups. Under similar conditions, trial group received 1.5 mg/kg of lidocaine for 90 s before cannulation and control group received normal saline. Hemodynamic parameters of patients including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and central venous pressure before cannulation and 1, 3, and 5 min after cannulation were recorded in a form...
June 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28932199/bacillus-a-biological-tool-for-crop-improvement-through-bio-molecular-changes-in-adverse-environments
#17
REVIEW
Ramalingam Radhakrishnan, Abeer Hashem, Elsayed F Abd Allah
Crop productivity is affected by environmental and genetic factors. Microbes that are beneficial to plants are used to enhance the crop yield and are alternatives to chemical fertilizers and pesticides. Pseudomonas and Bacillus species are the predominant plant growth-promoting bacteria. The spore-forming ability of Bacillus is distinguished from that of Pseudomonas. Members of this genus also survive for a long time under unfavorable environmental conditions. Bacillus spp. secrete several metabolites that trigger plant growth and prevent pathogen infection...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28930962/attenuation-of-hemorrhage-associated-lung-injury-by-adjuvant-treatment-with-c23-an-oligopeptide-derived-from-cold-inducible-rna-binding-protein
#18
Fangming Zhang, Weng-Lang Yang, Max Brenner, Ping Wang
BACKGROUND: Hemorrhagic shock (HS) is an important cause of mortality. HS is associated with an elevated incidence of acute lung injury and acute respiratory distress syndrome, significantly contributing to HS morbidity and mortality. Cold-inducible RNA-binding protein (CIRP) is released into the circulation during HS and can cause lung injury. C23 is a CIRP-derived oligopeptide that binds with high affinity to the CIRP receptor and inhibits CIRP-induced phagocyte secretion of TNF-α...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930834/allergic-shock-caused-by-ingestion-of-cooked-jellyfish-a-case-report
#19
Zhixing Li, Xungang Tan, Botao Yu, Renliang Zhao
RATIONALE: Although anaphylaxis caused by jellyfish stings is common in coastal areas, an allergic shock caused by cooked jellyfish ingestion has never been reported in China. In this paper, we report a case of allergic shock being caused by ingestion of cooked salt-preserved jellyfish shortly after being stung by a live jellyfish. PATIENT CONCERNS: A 26-year-old Chinese man presented with dizziness, pruritus, dyspnea, hypotension, and tachycardia after eating cooked salted jellyfish...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28930830/effect-of-dexmedetomidine-as-an-adjuvant-to-ropivacaine-for-wound-infiltration-in-patients-undergoing-open-gastrectomy-a-prospective-randomized-controlled-trial
#20
Hengfei Luan, Pin Zhu, Xiaobao Zhang, Liang Tian, Jiying Feng, Yong Wu, Yongxin Yan, Zhibin Zhao, Xiaoping Gu
OBJECTIVES: The primary objective of this study was to investigate whether dexmedetomidine could potentiate the analgesic efficacy of ropivacaine, when added to ropivacaine for wound infiltration in patients undergoing open gastrectomy. METHODS: Fifty patients scheduled for open gastrectomy were divided into 2 equal groups that were received wound infiltration using 20 mL 0.3% ropivacaine plus 2 mL normal saline (group R) or 20 mL 0.3% ropivacaine plus 2 mL 1...
September 2017: Medicine (Baltimore)
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