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https://www.readbyqxmd.com/read/29333139/a-framework-for-an-alternatives-assessment-dashboard-for-evaluating-chemical-alternatives-applied-to-flame-retardants-for-electronic-applications
#1
Todd M Martin
The goal of alternatives assessment (AA) is to facilitate a comparison of alternatives to a chemical of concern, resulting in the identification of safer alternatives. A two stage methodology for comparing chemical alternatives was developed. In the first stage, alternatives are compared using a variety of human health effects, ecotoxicity, and physicochemical properties. Hazard profiles are completed using a variety of online sources and quantitative structure activity relationship models. In the second stage, alternatives are evaluated utilizing an exposure/risk assessment over the entire life cycle...
May 1, 2017: Clean Technologies and Environmental Policy
https://www.readbyqxmd.com/read/29333041/pharmacological-evaluation-of-hepatoprotective-activity-of-ahpl-aytab-0613-tablet-in-carbon-tetrachloride-ethanol-and-paracetamol-induced-hepatotoxicity-models-in-wistar-albino-rats
#2
Sanjay U Nipanikar, Sohan S Chitlange, Dheeraj Nagore
Background: Hepatotoxicity ultimately leads to liver failure. Conventional treatment options for hepatotoxicity are limited and not safe. Objective: Formulation AHPL/AYTAB/0613 is developed to provide safer and effective hepatoprotective drug of natural origin. A study was conducted to evaluate hepatoprotective activity of AHPL/AYTAB/0613 (three dosages) in comparison with marketed formulations in carbon tetrachloride (CCl4), ethanol, and paracetamol-induced hepatotoxicity in Wistar albino rats...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29331789/anticonvulsant-activities-of-%C3%AE-asaronol-e-3-hydroxyasarone-an-active-constituent-derived-from-%C3%AE-asarone
#3
Xirui He, Yajun Bai, Min Zeng, Zefeng Zhao, Qiang Zhang, Ning Xu, Fanggang Qin, Xiaoyang Wei, Meimei Zhao, Ni Wu, Zehua Li, Yajun Zhang, Tai-Ping Fan, Xiaohui Zheng
BACKGROUND: Epilepsy is one of chronic neurological disorders that affects 0.5-1.0% of the world's population during their lifetime. There is a still significant need to develop novel anticonvulsant drugs that possess superior efficacy, broad spectrum of activities and good safety profile. METHODS: α-Asaronol and two current antiseizure drugs (α-asarone and carbamazepine (CBZ)) were assessed by in vivo anticonvulsant screening with the three most employed standard animal seizure models, including maximal electroshock seizure (MES), subcutaneous injection-pentylenetetrazole (PTZ)-induced seizures and 3-mercaptopropionic acid (3-MP)-induced seizures in mice...
August 31, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29330172/origins-of-tobacco-harm-reduction-in-the-uk-the-product-modification-programme-1972-1991
#4
Jesse Elias, Pamela M Ling
OBJECTIVE: To better understand the current embrace of long-term nicotine maintenance by British governmental agencies and tobacco harm reduction by several leading British public health organisations, describe the context and deliberations of the UK's first formal tobacco risk reduction programme: 'Product Modification'. METHODS: Analysis of previously secret tobacco industry documents, news archives and Parliamentary debate records. RESULTS: From 1972 to 1991, the British government sought to investigate safer smoking through the 'product modification programme'...
January 12, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29330008/electrophysiological-brain-indices-of-risk-behavior-modification-induced-by-contingent-feedback
#5
Alberto Megías, Miguel Angel Torres, Andrés Catena, Antonio Cándido, Antonio Maldonado
The main aim of this research was to study the effects of response feedback on risk behavior and the neural and cognitive mechanisms involved, as a function of the feedback contingency. Sixty drivers were randomly assigned to one of three feedback groups: contingent, non-contingent and no feedback. The participants' task consisted of braking or not when confronted with a set of risky driving situations, while their electroencephalographic activity was continuously recorded. We observed that contingent feedback, as opposed to non-contingent feedback, promoted changes in the response bias towards safer decisions...
January 9, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29329053/long-term-safety-area-tracking-lt-sat-with-online-failure-detection-and-recovery-for-robotic-minimally-invasive-surgery
#6
Veronica Penza, Xiaofei Du, Danail Stoyanov, Antonello Forgione, Leonardo S Mattos, Elena De Momi
Despite the benefits introduced by robotic systems in abdominal Minimally Invasive Surgery (MIS), major complications can still affect the outcome of the procedure, such as intra-operative bleeding. One of the causes is attributed to accidental damages to arteries or veins by the surgical tools, and some of the possible risk factors are related to the lack of sub-surface visibilty. Assistive tools guiding the surgical gestures to prevent these kind of injuries would represent a relevant step towards safer clinical procedures...
December 22, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29327737/uphill-downhill-nystagmus
#7
M Gufoni
Differential diagnosis between peripheral and central spontaneous nystagmus can be difficult to classify (as peripheral or central) even on the basis of criteria recommended in the recent literature. The aim of this paper is to use the combination of spontaneous nystagmus and ocular tilt reaction to determine the site of origin of the disease that causes nystagmus. We propose to classify the nystagmus in: 1) "Uphill" nystagmus in which the nystagmus takes on an inclined plane and the direction of the fast phase is towards the hypertropic eye (this type of nystagmus is likely peripheral); 2) "Downhill" nystagmus when the nystagmus beats toward the hypotropic eye (this type of nystagmus is likely central); 3) "Flat" nystagmus when the plane on which nystagmus beats is perfectly horizontal: in this case, we cannot say anything about the site of lesion (it was only detected in 15% of cases)...
December 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29327674/insoluble-microenvironment-facilitating-the-generation-and-maintenance-of-pluripotency
#8
Xiaofang Chen, Jiaqi Li, Yan Huang, Peng Liu, Yubo Fan
Induced pluripotent stem cells (iPSCs) hold enormous potential as a tool to generate cells for tissue engineering and regenerative medicine. Since the initial report of iPSCs in 2006, many different methods have been developed in order to enhance the safety and efficiency of this technology. Recent studies indicate that the extracellular signals can promote the production of iPSCs, and even replace the Yamanaka factors. Noticeably, abundant evidences suggest that the insoluble microenvironment, including the culture substrate and neighboring cells, directly regulates the expression of core pluripotency genes and the epigenetic modification of the chromatins, hence impact the reprogramming dynamics...
January 12, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29326520/the-so-called-garr%C3%A3-s-osteomyelitis-of-jaws-and-the-pivotal-utility-of-computed-tomography-scan
#9
Marco Túllio Brazão-Silva, Tiago Novaes Pinheiro
The present paper draw the attention of clinicians to investigate multiple slices of the computed tomography (CT) scan looking for a safe diagnosis of the so-called Garrè's osteomyelitis (GO) of jaws, a not uncommon disease characterized by astonishing bone growth. We report a case involving the left mandible of a 12-year-old girl presenting with a bony enlargement at left mandible. Initial examination revealed carious process of tooth 36 with radiographic apical rarefaction. However, we need to take care with this diagnosis because other aggressive diseases may cause bone enlargement mimicking GO...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326518/toothpaste-use-protocol-with-dental-bleaching-for-a-conservative-treatment-case-reports
#10
Waldemir F Vieira-Junior, Thayla H N Gouveia, Bruna G Silva, Vanessa C P S Bueno, Flávio H B Aguiar, Débora A N L Lima
In-office bleaching is a treatment based on products that contain hydrogen peroxide (HP) while demonstrating whitening effectiveness. HP could promote alterations to surface morphologies and properties of dental tissues. The objective was describe a toothpaste protocol associated to bleaching therapy to promote a safer approach. Patient 1 (male) and Patient 2 (female) were attended, and toothbrushing (twice a day) with a dentifrice containing bioactive glass (BG) (NovaMin™) and fluoride was indicated before and during the treatment...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326467/better-easier-safer-disinfectant
#11
(no author information available yet)
No abstract text is available yet for this article.
January 12, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29325947/usefulness-of-oblique-coronal-ct-and-mri-imaging-in-the-endoscopic-endonasal-approach-to-treat-skull-base-lesions
#12
Shigetoshi Yano, Naoki Shinojima, Mika Kitajima, Hiroyuki Uetani, Takuichiro Hide, Akitake Mukasa
OBJECTIVE: This report examines the utility of the preoperative image to orientate the surgeon in the sphenoid sinus during an endoscopic endonasal transsphenoidal approach (ETSS). METHODS: ETSS was performed in 100 cases of sellar lesion and used to classify the sphenoid sinus septum shape. Preoperative CT and MRI scans were taken for two types of coronal imaging: conventional and oblique. Expected sphenoid sinus septum shape was compared with those from ETSS to estimate concordance...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325708/promising-roles-for-pharmacists-in-addressing-the-u-s-opioid-crisis
#13
Wilson M Compton, Christopher M Jones, Jack B Stein, Eric M Wargo
Overdoses of prescription or illicit opioids claimed the lives of 116 Americans each day in 2016, and the crisis continues to escalate. As healthcare systems evolve to address the crisis, the potential of pharmacists to make a positive difference is significant. In addition to utilizing available prescription drug monitoring programs to help prevent diversion of opioids, practicing pharmacists can be alert for signs of opioid misuse by patients (e.g., multiple prescriptions from different physicians) as well as inappropriate prescribing or hazardous drug combinations that physicians may not be aware of (e...
December 31, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29325515/safer-chairs-for-elderly-patients-design-evaluation-using-electromyography-and-force-measurement
#14
Shabboo Valipoor, Debajyoti Pati, Matt S Stock, Doug Bazuin
A vast majority of patient fall events in hospitals involve the elderly. In inpatient care settings, despite the risk of fall, patients are encouraged to leave their bed, move around their room, and sit on their chair to progress in their healing. Despite the vital role of patient chair design in improving recovery, few studies have examined the ergonomic requirements of safe patient chairs. This study examined the impact of manipulating horizontal and vertical positions of armrests in a test chair on required physical effort during Stand-to-Sit-to-Stand (St-Si-St) transitions among fifteen elderly women...
January 11, 2018: Ergonomics
https://www.readbyqxmd.com/read/29324429/a-pilot-clinical-study-of-a-safe-and-efficient-stool-management-system-in-patients-with-fecal-incontinence
#15
Ashlee Garcia, Sally Fung, Karen Lou Kennedy-Evans
INTRODUCTION: According to the Wound Ostomy Continence Nursing Society's Continence Committee, the incidence of fecal incontinence (FI) can occur from 18% to 37% in an acute care setting. A stool management system has been designed to manage FI in bedridden patients and has proven to be efficacious in wound management and prevention and infection control, provide safer patient outcomes, and enhance ease of nursing. OBJECTIVE: This study aims to evaluate the safety and efficacy of an intrarectal device intended to manage fecal incontinence in hospitalized bedridden patients through nonclinical and clinical testings...
December 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29323614/evaluation-of-anionic-surfactants-effects-on-the-skin-barrier-function-based-of-skin-permeability
#16
Mana Okasaka, Koji Kubota, Emi Yamasaki, Jianzhong Yang, Sadaki Takata
Anionic surfactants are often used for cleaning and pharmaceutical purposes because of their strong surfactancy and foaming property. However, they are rarely ingested orally, the skin is a part of human body most affected by surfactants. Barrier function of the skin is very strong, but the anionic surfactants can serious damage it. Recently, amino acid-based surfactants have attracted attentions as safer options owing to their biocompatibility. Cytotoxicity examinations revealed the amino acid-based surfactants are superior to sulfate-based surfactants...
January 11, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29323609/e-cigarettes-use-effects-on-smoking-risks-and-policy-implications
#17
Stanton A Glantz, David W Bareham
Since e-cigarettes appeared in the mid-2000s, some practitioners, researchers, and policy makers have embraced them as a safer alternative to conventional cigarettes and an effective way to stop smoking. While e-cigarettes deliver lower levels of carcinogens than do conventional cigarettes, they still expose users to high levels of ultrafine particles and other toxins that may substantially increase cardiovascular and noncancer lung disease risks, which account for more than half of all smoking-caused deaths, at rates similar to conventional cigarettes...
January 11, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29323471/synthesis-of-n-substituted-iminosugar-derivatives-and-evaluation-of-their-immunosuppressive-activities
#18
Xinshan Ye, Qin Li
It is important to find more effective and safer immunosuppressants because the clinically-used immunosuppressive agents have significant side-effects. A series of N-substituted iminosugar derivatives were designed and synthesized, and their immunosuppressive effects were evaluated by CCK-8 assay. The results revealed that iminosugars 10e and 10i exhibited the strongest inhibitory effect on mouse splenocyte proliferation (IC50 = 2.16 and 2.48 μM, respectively), whereas the iminosugars containing an amide group near the hydrophilic head (compounds 10j-n) exhibited no inhibitory effects...
January 11, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29323232/comparison-of-bladder-carcinogens-in-the-urine-of-e-cigarette-users-versus-non-e-cigarette-using-controls
#19
Thomas W Fuller, Abhinav P Acharya, Thiagarajan Meyyappan, Michelle Yu, Godugu Bhaskar, Steven R Little, Tatum V Tarin
Electronic cigarette (EC) use is gaining popularity as a substitute for conventional smoking due to the perception and evidence it represents a safer alternative. In contrast to the common perception amongst users that ECs represent no risk initial studies have revealed a complex composition of e-cigarette liquids. Conventional cigarette smoking is a known risk factor for developing bladder cancer and prior reports raise concern some of those causative compounds may exist in EC liquids or vapor. Urine samples were collected from 13 e-cigarette using subjects and 10 non e-cigarette using controls...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322356/inherent-health-and-environmental-risk-assessment-of-nanostructured-metal-oxide-production-processes
#20
Mina Torabifard, Reza Arjmandi, Alimorad Rashidi, Jafar Nouri, Iraj Mohammadfam
The health and environmental effects of chemical processes can be assessed during the initial stage of their production. In this paper, the Chemical Screening Tool for Exposure and Environmental Release (ChemSTEER) software was used to compare the health and environmental risks of spray pyrolysis and wet chemical techniques for the fabrication of nanostructured metal oxide on a semi-industrial scale with a capacity of 300 kg/day in Iran. The pollution sources identified in each production process were pairwise compared in Expert Choice software using indicators including respiratory damage, skin damage, and environmental damages including air, water, and soil pollution...
January 10, 2018: Environmental Monitoring and Assessment
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