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https://www.readbyqxmd.com/read/29144822/testosterone-levels-achieved-by-medically-treated-transgender-women-in-a-united-states-endocrinology-clinic-cohort
#1
Jennifer J Liang, Divya Jolly, Kelly J Chan, Joshua D Safer
OBJECTIVE: Most transgender women depend on medical treatment alone to lower testosterone levels in order to align physical appearance with gender identity. The medical regimen in the United States typically includes spironolactone and estrogens. The purpose of this cross-sectional study was to assess the testosterone suppression achieved among transgender women treated with spironolactone and estrogens. METHODS: Testosterone and estradiol levels were extracted from the electronic medical records of 98 anonymized transgender women treated with oral spironolactone and oral estrogen therapy at the Endocrinology Clinic at Boston Medical Center...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29143695/an-overview-of-systematic-reviews-of-pharmacological-and-non-pharmacological-interventions-for-the-treatment-of-behavioral-and-psychological-symptoms-of-dementia
#2
Suzanne M Dyer, Stephanie L Harrison, Kate Laver, Craig Whitehead, Maria Crotty
BACKGROUND: This systematic overview reports findings from systematic reviews of randomized controlled trials of pharmacological and non-pharmacological interventions for behavioural and psychological symptoms of dementia (BPSD). METHODS: The Cochrane Database of Systematic Reviews, DARE, Medline, EMBASE, and PsycINFO were searched to September 2015. RESULTS: Fifteen systematic reviews of eighteen different interventions were included. A significant improvement in BPSD was seen with: functional analysis-based interventions (GRADE quality of evidence moderate; standardized mean difference (SMD) -0...
November 16, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29143094/the-application-of-a-performance-based-self-administered-intra-procedural-checklist-on-surgical-trainees-during-laparoscopic-cholecystectomy
#3
Michael El Boghdady, Afshin Alijani
INTRODUCTION: Surgical checklists are in use to reduce errors for safer surgery. We aimed to study the effect of a previously designed performance-based self-administered intra-procedural checklist on the performance of trainees during elective laparoscopic cholecystectomy. METHODS: Twenty-four laparoscopic cholecystectomies were enrolled into the study. Six surgical trainees each performed four procedures, two without the checklist and directly followed by two procedures with the checklist...
November 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29142594/micrornas-a-subpopulation-of-regulators-are-involved-in-breast-cancer-progression-through-regulating-breast-cancer-stem-cells
#4
Xuemei Fan, Wei Chen, Ziyi Fu, Lihua Zeng, Yongmei Yin, Hongyan Yuan
Cancer stem cells (CSCs; also known as tumor-initiating cells) are essential effectors of tumor progression due to their self-renewal capacity, differentiation potential, tumorigenic ability and resistance to chemotherapy, all of which contribute to cancer relapse, metastasis and a poor prognosis. Breast cancer stem cells (BCSCs) have been identified to be involved in the processes of BC initiation, growth and recurrence. MicroRNAs (miRNAs) are a class of non-coding small RNAs of 19-23 nucleotides in length that regulate gene expression at the post-transcriptional level through various mechanisms, and serve critical roles in cancer progression...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29142447/a-prospective-randomized-study-comparing-unipolar-versus-bipolar-hysteroscopic-myomectomy-in-infertile-women
#5
Kallol K Roy, Sandeep Metta, Yamini Kansal, Sunesh Kumar, Seema Singhal, Perumal Vanamail
Study Objective: To compare the operative and reproductive outcome of hysteroscopic myomectomy using unipolar resectoscope versus bipolar resectoscope in patients with infertility and menorrhagia. Design: Randomized, prospective, parallel, comparative, single-blinded study. Design Classification: Canadian Task Force classification I. Setting: Tertiary care institute. Patients: Sixty women with submucous myoma and infertility...
July 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29141769/turning-attention-to-clinician-engagement-in-victoria
#6
Christine Jorm, Robyn Hudson, Euan Wallace
The engagement of clinicians with employing organisations and with the broader health system results in better safer care for patients. Concerns about the adequacy of clinician engagement in the state of Victoria led the Victorian Department of Health and Human Services to commission a scoping study. During this investigation more than 100 clinicians were spoken with and 1800 responded to surveys. The result was creation of a clear picture of what engagement and disengagement looked like at all levels - from the clinical microsystem to state health policy making...
November 16, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29141695/methylxanthines-induce-structural-and-functional-alterations-of-the-cardiac-system-in-zebrafish-embryos
#7
Ram Manohar Basnet, Daniela Zizioli, Michela Guarienti, Dario Finazzi, Maurizio Memo
BACKGROUND: Zebrafish embryos are emerging as a model for pharmacological and toxicological studies. We used zebrafish embryos to study the general toxicity and cardiovascular effects of eight methylxanthines: aminophylline, caffeine, diprophylline, doxofylline, etophylline, 3-isobutyl-1-methylxanthine (IBMX), pentoxifylline and theophylline. METHODS: Microinjections of the eight methylxanthines were performed in 1-2 cell stage zebrafish embryos and the general toxicity and cardiovascular effects were analyzed at different time points...
November 15, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29140593/nursing-perception-of-risk-in-common-nursing-practice-situations
#8
Pamela Trevino, Angela Green, Donna Middaugh, Seonghum Heo, Claudia Beverly, Jayant Deshpande
As health care organizations seek to be highly reliable, systems that include layers of redundancy have been created to protect patients from harm. Many of these layers of protection are dependent on nurses making a decision to follow or adhere to the human aspects of the process. Because these decisions begin with a perception and identification of risk, understanding what nurses perceive to be a risk to patients is an essential part of designing safer health care systems. The purposes of this qualitative study were to (1) describe what nurses perceive as risky to patients in common nursing practice situations, (2) describe the effects of the perceptions of risk on clinical decision making and behavior, and (3) identify what factors nurses perceive as increasing or decreasing risk...
November 15, 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/29138902/-use-of-e%C3%A2-cigarettes-as-an-additional-tool-in-a%C3%A2-smoking-cessation-group-intervention-results-after-12%C3%A2-months
#9
Christoph B Kröger, Sarah Ofner, Daniela Piontek
BACKGROUND: E-cigarettes are considerably safer regarding health issues than conventional cigarettes, but there is uncertainty concerning its use for smoking cessation. OBJECTIVES: How and to what extent are E‑cigarettes used by smokers willing to quit? Are E‑cigarettes a useful intervention for smokers attending a group intervention for smoking cessation? MATERIALS AND METHODS: One year after attending a group intervention for smoking cessation in Germany, 637 attendants were assessed by telephone...
November 14, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29138779/ion-solvation-structure-and-battery-electrode-characteristics-of-nonflammable-organic-electrolytes-based-on-tris-trifluoroethyl-phosphate-dissolving-lithium-salts
#10
Yanko Marinov Todorov, Kenta Fujii, Nobuko Yoshimoto, Daisuke Hirayama, Masahiro Aoki, Hideyuki Mimura, Masayuki Morita
The structure and properties of lithium salt solutions based on tris(2,2,2-trifluoroethyl)phosphate (TFEP) solvent have been studied to design a safer electrolyte system for large-sized lithium-ion battery applications. Influences of the ionic structure on the polarization behavior of the LiCoO2 (LCO) positive electrode were investigated. The ionic conductivity and viscosity of the solution consisting of lithium salts dissolved in TFEP, LiX/TFEP (X = PF6, BF4 and TFSA) (TFSA = (CF3SO2)2N), were measured. The results suggest that the ion-solvation structure greatly depends on the anionic species in the salt...
November 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29138075/the-optimal-treatment-options-of-septated-chronic-subdural-haematoma-a-retrospective-comparison-of-craniotomy-versus-endoscopic-assisted-burr-hole-craniostomy
#11
Jibo Zhang, Xingyue Fan, Xuemeng Liu, Jincao Chen, Wei Wang, Kai Fu
OBJECTIVE: To complete a retrospective comparison of endoscope-assisted burr-hole craniostomy (EBHC) and craniotomy in the treatment of septated chronic subdural hematoma (SCSH). METHODS: A retrospective case note review comparing EBHC and craniotomy of SCSH was therefore performed. Data of patients with a SCSH for EBHC or craniotomy during the period from January 2011 to January 2017 were retrospectively collected and analysed. Of 70 patients, 43 underwent EBHC and 27 patients were treated by craniotomy...
November 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29137810/technique-for-precaval-and-laterocaval-nodes-excision-at-extraperitoneal-paraaortic-lymphadenectomy
#12
M Gorostidi, C Villalain, R Ruiz, I Jaunarena, A Lekuona
STUDY OBJECTIVE: To describe our technique for excision of the pre-caval and laterocaval nodes using an extraperitoneal approach. This technique was developed to make the dissection and excision of the less accessible nodes in an easier and safer way by minimizing the risk of great vessels injury and bleeding. DESIGN: Step-by-step description of the surgical procedure using video (Canadian Task Force classification III). SETTING: The procedure was performed at a teaching hospital, Hospital Universitario Donostia (Spain)...
November 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29137557/the-impact-of-a-state-medicaid-peer-review-authorization-program-on-pediatric-use-of-antipsychotic-medications
#13
Dinci Pennap, Mehmet Burcu, Daniel J Safer, Julie Magno Zito
OBJECTIVE: This cross-sectional study assessed the impact of a peer-review program on the prevalence of pediatric antipsychotic use among Medicaid-insured youths in a Mid-Atlantic state. METHODS: Medicaid claims (2010-2014) were assessed among continuously enrolled youths in the 12 months before and after implementation of peer review. The study identified children ages zero to four preimplementation (N=118,815) and postimplementation (N=121,431), ages five to nine preimplementation (N=98,681) and postimplementation (N=107,872), and ages 10 to 17 preimplementation (N=154,696) and postimplementation (N=161,370)...
November 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29137080/a-medium-term-follow-up-of-adult-lumbar-tuberculosis-treating-with-3-surgical-approaches
#14
Qi Hong Zhang, Qiang Guo, Chaofeng Guo, Jianhuang Wu, Jinyang Liu, Qile Gao, Yuxiang Wang
Surgical intervention is an important option for treating lumbar tuberculosis. Previous studies have reported different surgical intervention procedures. To our knowledge, few studies have compared the clinical results of mid-term follow-up of 3 different surgeries in surgical treatment of spinal tuberculosis. This study's purpose is to evaluate the effectiveness of 3 different surgeries for the treatment of lumbar tuberculosis in adult and analyze the mid-term influence of the surgery on quality of life.Between June 2004 and January 2010, a total of 137 adult patients (54 women and 83 men) with lumbar tuberculosis were recruited for this study...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135671/support-for-safer-opioid-prescribing-practices-a-catalog-of-published-use-after-orthopaedic-surgery
#15
Francis Lovecchio, Peter Derman, Jeffrey Stepan, Sravisht Iyer, Alexander Christ, Peter Grimaldi, Kanupriya Kumar, Anil Ranawat, Samuel A Taylor
No abstract text is available yet for this article.
November 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29135272/-protecting-the-inferior-alveolar-nerve-coronectomy-of-lower-third-molars-review
#16
József Szalma, Edina Lempel
Coronectomy of lower impacted wisdom teeth is the partial removal of third molars, aiming to avoid inferior alveolar nerve injuries. The coronectomy procedure has several crucial points, such as the pulpal, periapical preoperative conditions of the tooth, the way of crown sectioning and decoronation, the wound closure and the length of patients' follow up. In addition it is important to identify and manage possible intraoperative or postoperative complications correctly. According to the literature, the complication rate of coronectomy is usually lower, than that of total teeth removal, furthermore considering inferior alveolar nerve injuries, coronectomy is significantly the safer procedure...
November 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29134821/navigating-unintelligibility-queer-australian-young-women-s-negotiations-of-safe-sex-and-risk
#17
Ruby Grant, Meredith Nash
Australian public health promotion positions safe sex as a biomedical, heteronormative concept. Consequently, there is a dearth of scholarly research examining queer young women's sexual health. To fill this knowledge gap, this article considers how Australian bisexual and queer young women understand 'safe sex' and conceptualise 'good' sexual citizenship. Drawing on qualitative interviews with 15 participants in Tasmania, findings reveal that although queer women understand heterosexual safe sex, there is little awareness of safer sexual practices with female partners...
November 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/29133924/bio-detoxification-of-ricin-in-castor-bean-ricinus-communis-l-seeds
#18
Natália L Sousa, Glaucia B Cabral, Pabline M Vieira, Aisy B Baldoni, Francisco J L Aragão
Ricin is a highly toxic ribosome-inactivating lectin occurring in the seeds of castor bean (Ricinus communis L.). Castor bean grows throughout tropical and sub-tropical regions and is a very important crop due to its high seed content of ricinoleic acid, an unusual fatty acid, which has several industrial applications. However, due to the presence of the toxin, castor bean can cause death after the exposure of animals to low doses of ricin through skin contact, injection, inhalation or oral routes. Aiming to generate a detoxified genotype, we explored the RNAi concept in order to silence the ricin coding genes in the endosperm of castor bean seeds...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133299/fatigue-and-risk-are-train-drivers-safer-than-doctors
#19
(no author information available yet)
No abstract text is available yet for this article.
November 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29133148/adventitious-viruses-in-insect-cell-lines-used-for-recombinant-protein-expression
#20
REVIEW
Christoph Geisler, Donald L Jarvis
Insect cells are widely used for recombinant protein expression, typically as hosts for recombinant baculovirus vectors, but also for plasmid-mediated transient transfection or stable genetic transformation. Insect cells are used to express proteins for research, as well as to manufacture biologicals for human and veterinary medicine. Recently, several insect cell lines used for recombinant protein expression were found to be persistently infected with adventitious viruses. This has raised questions about how these infections might affect research performed using those cell lines...
November 10, 2017: Protein Expression and Purification
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