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https://www.readbyqxmd.com/read/29786927/the-exhaled-nitric-oxide-and-mannitol-test-to-predict-exercise-induced-bronchoconstriction
#1
Kyubo Kim, Hong Je Cho, Jung Won Yoon, Sun Hee Choi, Youn Ho Sheen, ManYong Han, Heysung Baek
BACKGROUND: Exercise-induced bronchoconstriction (EIB) is diagnosed via exercise challenge on a treadmill. However, such testing requires complex equipment and sufficient healthcare resources. The fraction of exhaled nitric oxide (FeNO) test and mannitol bronchial provocation test (BPT) may serve as a surrogate of exercise testing. METHODS: We compared the diagnostic utilities of the FeNO test and mannitol BPT in predicting EIB in asthmatic children. We retrospectively analysed data from 60 asthmatic children aged 6-16 years...
May 22, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29786839/the-influence-of-scalded-flour-fermentation-and-plants-belonging-to-lamiaceae-family-on-the-wheat-bread-quality-and-acrylamide-content
#2
Elena Bartkiene, Vadims Bartkevics, Vita Krungleviciute, Iveta Pugajeva, Daiva Zadeike, Grazina Juodeikiene, Dalia Cizeikiene
The aim of this study was to investigate the influence of additives such as plants belonging to Lamiaceae family (Thymus vulgaris, Carum carvi, Origanum vulgare, Ocimum basilicum, and Coriandrum sativum), scalded flour (SF) or scalded flour fermented with Lactobacillus plantarum LUHS135 (SFFLp) on the quality and acrylamide formation in wheat bread. The formation of acrylamide and bread quality significantly depended on the king of plants used and the amount of SF and SFFLp used. The additives of T. vulgaris and SF increased the content of acrylamide by 3...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29786530/meta-analysis-of-safety-and-efficacy-of-oral-anti-coagulants-in-patients-requiring-catheter-ablation-for-atrial-fibrillation
#3
Hammad Rahman, Safi U Khan, Michael DePersis, Tehseen Hammad, Fahad Nasir, Edo Kaluski
BACKGROUND: The ideal oral anticoagulant agent during catheter ablation (CA) for atrial fibrillation (AF) remained unclear. HYPOTHESIS: Novel oral anticoagulants (NOACs) are safer and effective compared to uninterrupted vitamin K antagonists (U-VKA) among patients requiring CA for AF. METHODS: Four randomized controlled trials (RCTs) and 9 observational studies (OS) were selected using PubMed/Medline, EMBASE and the CENTRAL data bases (Inception-December-2017)...
May 9, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29785544/heartmate-ii-implantation-technique-that-spares-the-sternum-and-ascending-aorta
#4
Masashi Kawabori, Chitaru Kurihara, Tadahisa Sugiura, Andrew B Civitello, Jeffrey A Morgan
Left ventricular assist devices (LVADs) have become the standard therapy for patients with end-stage heart failure, and the use of LVADs for long-term support has grown exponentially over the past decade. As the number of LVAD implantations has increased, surgeons have faced more challenging cases, such as those in which the patient has previously undergone a sternotomy. The HeartMate II is one of the most widely implanted LVADs. The standard procedure for HeartMate II implantation is median sternotomy and sewing the outflow graft to the ascending aorta...
May 21, 2018: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/29784753/use-of-direct-oral-anticoagulants-for-treating-venous-thromboembolism-in-patients-with-cancer
#5
Gerald A Soff
For patients with cancer who experience venous thromboembolism (VTE), low-molecular-weight heparin (LMWH) remains the standard of care in the NCCN Guidelines for VTE, but under certain conditions direct oral anticoagulants (DOACs) are acceptable alternatives. A growing body of literature suggests that DOACs may more effective than LMWHs in preventing recurrences, but they do carry some increased risk of bleeding. Most of this risk is seen in patients with gastrointestinal or urinary pathology or implanted devices...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29784621/endoscope-assisted-retrosigmoid-approach-in-hemifacial-spasm-our-experience
#6
Giampietro Ricci, Arianna Di Stadio, Luca D'Ascanio, Ruggero La Penna, Franco Trabalzini, Antonio Della Volpe, Jacques Magnan
INTRODUCTION: The use of surgical decompression of facial hemispasm due to the loop in the internal auditory canal is not always accepted due to the risk related to the surgical procedure. Currently a new surgical technique allows surgeons to work in safer conditions. OBJECTIVE: To report the results with endoscope-assisted retrosigmoid approach for facial nerve microvascular decompression in hemifacial spasm due to neurovascular conflict. The surgical technique is described...
May 9, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29784216/physical-and-mechanical-restraint-in-psychiatric-units-perceptions-and-experiences-of-nursing-staff
#7
Kelly Graziani Giacchero Vedana, Danielle Maria da Silva, Carla Aparecida Arena Ventura, Bianca Cristina Ciccone Giacon, Ana Carolina Guidorizzi Zanetti, Adriana Inocenti Miasso, Tatiana Longo Borges
BACKGROUND: Physical restraint in psychiatric units is a common practice but extremely controversial and poorly evaluated by methodologically appropriate investigations. The cultural issues and professionals' perceptions and attitudes are substantial contributors to the frequency of restraint that tend to be elevated. Aim In this qualitative study, we aimed to understand the experiences and perceptions of nursing staff regarding physical restraint in psychiatric units. METHOD: Through theoretical sampling, 29 nurses from two Brazilian psychiatric units participated in the study...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29784112/technology-based-interventions-to-reduce-sexually-transmitted-infections-and-unintended-pregnancy-among-youth
#8
REVIEW
Laura Widman, Jacqueline Nesi, Kristyn Kamke, Sophia Choukas-Bradley, J L Stewart
PURPOSE: Technology-based interventions to promote sexual health have proliferated in recent years, yet their efficacy among youth has not been meta-analyzed. This study synthesizes the literature on technology-based sexual health interventions among youth. METHODS: Studies were included if they (1) sampled youth ages 13-24; (2) utilized technology-based platforms; (3) measured condom use or abstinence as outcomes; (4) evaluated program effects with experimental or quasi-experimental designs; and (5) were published in English...
June 2018: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29783277/how-safe-is-safe-enough-for-self-driving-vehicles
#9
Peng Liu, Run Yang, Zhigang Xu
Self-driving vehicles (SDVs) promise to considerably reduce traffic crashes. One pressing concern facing the public, automakers, and governments is "How safe is safe enough for SDVs?" To answer this question, a new expressed-preference approach was proposed for the first time to determine the socially acceptable risk of SDVs. In our between-subject survey (N = 499), we determined the respondents' risk-acceptance rate of scenarios with varying traffic-risk frequencies to examine the logarithmic relationships between the traffic-risk frequency and risk-acceptance rate...
May 21, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29783088/evaluation-of-genotoxicity-and-mutagenic-effects-of-vector-dna-nanocomplexes-in-transfected-mesenchymal-stem-cells-by-flow-cytometry
#10
Alireza Nomani, Xuguang Chen, Arash Hatefi
In recent years, there has been a great deal of interest in ex-vivo genetic modification of mesenchymal stem cells (MSCs) to meet various biomedical needs. Considering the self-renewal potential of MSCs, it is critically important to ensure that transfection vectors (gene carriers) do not induce genotoxicity because they could theoretically turn a single stem cell into a cancer-initiating cell. Unfortunately, there is currently no reliable, unbiased, and quantitative method to measure genotoxicity (micronuclei formation) of gene carriers directly in transfected MSCs...
May 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29782508/parent-and-caregiver-perceptions-about-the-safety-and-effectiveness-of-foreign-and-domestic-vaccines-in-shanghai-china
#11
Zhuoying Huang, Xiaodong Sun, Abram L Wagner, Jia Ren, Matthew L Boulton, Lisa A Prosser, Brian J Zikmund-Fisher
BACKGROUND: Chinese parents have access to domestic and foreign vaccines for their children. Their vaccine preferences are unclear, especially given recent pharmaceutical quality scandals and widely held beliefs deriving from Traditional Chinese Medicine (TCM). This study characterized parental beliefs about the safety and effectiveness of Chinese and foreign vaccines. METHODS: In May 2014, caregivers of young children at public immunization clinics in Shanghai, China, responded to a survey on vaccine perceptions...
2018: PloS One
https://www.readbyqxmd.com/read/29781938/physical-demands-of-amateur-domestic-and-representative-netball-in-one-season-in-new-zealand-assessed-using-heart-rate-and-movement-analysis
#12
Doug A King, Cloe Cummins, Patria A Hume, Trevor N Clark
King, DA, Cummins, C, Hume, PA, and Clark, TN. Physical demands of amateur domestic and representative netball in one season in New Zealand assessed using heart rate and movement analysis. J Strength Cond Res XX(X): 000-000, 2018-The purpose of this descriptive cohort study was to describe physical demands of netball for positions and between playing levels using microtechnology. Data were collected from 34 female netball players across 3 teams at different levels (over 19 years representative [O19], under 19 years representative [U19], and open-age amateur club domestic) for 20 games using heart rate and microtechnology data...
May 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29781751/posology-adjustments-of-oral-antineoplastic-agents-for-special-populations-patients-with-renal-impairment-hepatic-impairment-and-hematologic-toxicities
#13
Julieta González, Matías Quiroga, Vicente Escudero-Vilaplana, Roberto Collado-Borrell, Ana Herranz-Alonso, María Sanjurjo Sáez
BACKGROUND: Oral antineoplastic agents (OAA) have reached 30-50% of all antineoplastic treatments. Although they seem safer than parenteral therapy, many severe problems can occur if the dose is not adequately adjusted in special situations. Our objective is to create a comprehensive guide with dosage adjustment recommendations for OAA in cases of renal and hepatic impairment and hematologic toxicities. RESEARCH DESIGN AND METHODS: We analyzed all OAA approved by EMA in July 2017...
May 21, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29781579/poverty-neighborhoods-persistent-stress-and-sle-outcomes-a-qualitative-study-of-the-patients-perspective
#14
Edward Yelin, Laura Trupin, Jared Bunde, Jinoos Yazdany
OBJECTIVE: To obtain the perspective of individuals with SLE about the role of poverty, neighborhood, and chronic stress in SLE outcomes. METHODS: 723 persons with SLE were followed from 2003-2015 through annual structured interviews as part of the Lupus Outcomes Study to establish the effect of combinations of poverty, persistent poverty, living in an area of concentrated poverty, access to health care, and chronic stress on accumulated damage. We sampled 28 from the 723 on the basis of household income, geography, and outcomes in their last interview, and administered qualitative interviews to explore their perspectives on these factors on outcomes...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29781069/dual-and-triple-antithrombotic-therapies-current-patterns-of-practice-and-controversies
#15
Mark Crowther, John Eikelboom
Dual antiplatelet therapy (DAPT) has been the cornerstone of antithrombotic management for patients undergoing percutaneous coronary intervention (PCI). Despite low-quality evidence, triple antithrombotic therapy involving acetylsalicylic acid, clopidogrel and warfarin or non-vitamin K antagonist oral anticoagulant (NOAC) has been recommended in patients with concomitant atrial fibrillation undergoing PCI, who require long-term oral anticoagulation, although such strategy is associated with a substantially increased risk of bleeding compared with DAPT...
May 21, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29780259/delivery-of-bevacizumab-by-intracranial-injection-assessment-in-glioma-model
#16
Yu-Xiao Liu, Wen-Jia Liu, Hui-Ru Zhang, Zhi-Wen Zhang
Background: Many reports have indicated that the intravenous administration of bevacizumab produces a number of systemic side effects. Therefore, we investigated the therapeutic effects of intratumoral bevacizumab administration using a glioma animal model. Methods: The glioma cell lines U251 and U87 that carried luciferase were implanted into the brains of mice to develop glioma models. Glioma-bearing mice were treated with bevacizumab intravenously or intratumorally by Alzet micro-osmotic pumps, and the survival time of mice was monitored...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29779485/tgn-1412-and-bia-2474-trials-with-tragic-end-lessons-learnt-to-make-clinical-trials-safer
#17
Rimple Jeet Kaur, Surjit Singh, Preeti Sidhu, Pramod Kumar Sharma
BACKGROUND: Globally, there have been tremendous efforts by regulatory authorities to make clinical trials safer by making stringent clinical trial regulations. Despite this, we witnessed several tragic events. TGN1412 and BIA 10-2474 phase I trials are infamous trails in which healthy volunteers either succumbed to severe adverse effects or faced irreversible impairments of the test drug. Such afflictions in clinical trials are not only turbulent to the image of pharmaceutical industry but it also conveys dispiriting message for clinical trial participants...
May 20, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29779418/modeling-adverse-event-counts-in-phase-i-clinical-trials-of-a-cytotoxic-agent
#18
Daniel G Muenz, Thomas M Braun, Jeremy Mg Taylor
Background/Aims The goal of phase I clinical trials for cytotoxic agents is to find the maximum dose with an acceptable risk of severe toxicity. The most common designs for these dose-finding trials use a binary outcome indicating whether a patient had a dose-limiting toxicity. However, a patient may experience multiple toxicities, with each toxicity assigned an ordinal severity score. The binary response is then obtained by dichotomizing a patient's richer set of data. We contribute to the growing literature on new models to exploit this richer toxicity data, with the goal of improving the efficiency in estimating the maximum tolerated dose...
May 1, 2018: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29777894/endoscopic-transnasal-resection-of-solitary-fibrous-tumor-in-the-optic-canal
#19
Seiei Torazawa, Masahiro Shin, Hirotaka Hasegawa, Ryohei Otani, Keisuke Ueki, Nobuhito Saito
BACKGROUND: Tumors extending into the optic canal can cause progressive visual impairment due to optic nerve compression, and prompt surgical resection is often necessary. When the tumor is located medially in the optic canal, endoscopic transnasal surgery provides a safer, less invasive alternative to trans-cranial approach. CASE DESCRIPTION: We recently encountered a case of small solitary fibrous tumor in the optic canal causing rapid visual deterioration. The radiographic findings of pre-operative imaging studies were compatible with those of meningioma; however, unlike meningioma, bleeding from the tumor was very profuse during the operation...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29777759/plant-nutraceuticals-as-antimicrobial-agents-in-food-preservation-terpenoids-polyphenols-and-thiols
#20
REVIEW
Ignacio Gutiérrez-Del-Río, Javier Fernández, Felipe Lombó
Synthetic food additives generate a negative perception in consumers. Therefore, food manufacturers search for safer natural alternatives as those involving phytochemicals and plant essential oils. These bioactives have antimicrobial activities widely proved in in vitro tests. Foodborne diseases cause thousands of deaths and millions of infections every year, mainly due to pathogenic bacteria as Salmonella spp., Campylobacter spp., Escherichia coli, Bacillus cereus, Listeria monocytogenes or Staphylococcus aureus...
May 16, 2018: International Journal of Antimicrobial Agents
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