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pulmonary involvement rheumatoid arthritis

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https://www.readbyqxmd.com/read/27733490/therapeutic-management-of-patients-with-rheumatoid-arthritis-and-associated-interstitial-lung-disease-case-report-and-literature-review
#1
Andrea Picchianti Diamanti, Milica Markovic, Giuseppe Argento, Simonetta Giovagnoli, Alberto Ricci, Bruno Laganà, Raffaele D'Amelio
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that can present different extrarticular manifestations involving heart, lungs and kidneys. In recent years there has been a growing awareness of the central role played by the lungs in the onset and progression of RA. In particular interstitial lung disease (ILD) is a common pulmonary manifestation that may be related to the inflammatory process itself, infectious complications and to the treatments used. Management of patients with ILD/RA is still a challenge for clinicians, both synthetic [mainly methotrexate (MTX), leflunomide] and biologic immunosuppressors [mainly anti-tumor necrosis factor (TNF)α] have in fact been related to the onset or worsening of lung diseases with conflicting data...
October 12, 2016: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/27726047/elevated-serum-levels-of-soluble-cd146-in-patients-with-systemic-sclerosis
#2
Tomoko Ito, Naoto Tamura, Sayuri Okuda, Kurisu Tada, Masakazu Matsushita, Ken Yamaji, Kazunori Kato, Yoshinari Takasaki
CD146, a transmembrane glycoprotein member of the immunoglobulin superfamily, acts as an adhesion molecule that helps maintain the cell monolayer. Human endothelial cells expressing CD146 are involved in angiogenesis and inflammation. Recently, we developed a sandwich ELISA for detecting soluble CD146 (sCD146) in human serum specimens. The aim of this study is to determine serum levels of sCD146 in patients with systemic sclerosis (SSc) and to examine the relationship between sCD146 levels and clinical manifestations...
October 11, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27659711/-pulmonary-manifestations-in-collagen-vascular-diseases
#3
M N A Vogel, M Kreuter, H-U Kauczor, C-P Heußel
CLINICAL/METHODICAL ISSUE: Pulmonary complications are frequent in patients with collagen vascular diseases (CVD). Frequent causes are a direct manifestation of the underlying disease, side effects of specific medications and lung infections. STANDARD RADIOLOGICAL METHODS: The standard radiological procedure for the work-up of pulmonary pathologies in patients with CVD is multidetector computed tomography (MDCT) with thin-slice high-resolution reconstruction. PERFORMANCE: The accuracy of thin-slice CT for the identification of particular disease patterns is very high...
October 2016: Der Radiologe
https://www.readbyqxmd.com/read/27604426/methotrexate-induced-epithelial-mesenchymal-transition-in-the-alveolar-epithelial-cell-line-a549
#4
Masashi Kawami, Rika Harabayashi, Mioka Miyamoto, Risako Harada, Ryoko Yumoto, Mikihisa Takano
PURPOSE: Methotrexate (MTX) therapy of certain cancers and rheumatoid arthritis often induces serious interstitial lung complications including pulmonary fibrosis. In this study, we investigated the epithelial-mesenchymal transition (EMT) induced by MTX and by transforming growth factor (TGF)-β1 in the human alveolar epithelial cell line A549 in order to develop new strategies for the prevention of EMT. METHODS: First, we examined the effect of TGF-β1 and MTX on cell morphology and the expression of EMT-related mRNAs in A549 cells...
September 7, 2016: Lung
https://www.readbyqxmd.com/read/27578952/rheumatoid-arthritis-associated-interstitial-lung-disease-1-year-is-too-much-to-exclude-methotrexate-induced-pulmonary-involvement
#5
Ashok Kuwal, Naveen Dutt, Nishant Chauhan
No abstract text is available yet for this article.
July 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27578034/effects-of-vla-1-blockade-on-experimental-inflammation-in-mice
#6
Ryuichi Totsuka, Takaaki Kondo, Shigeki Matsubara, Midori Hirai, Yoichi Kurebayashi
VLA-1 (very late antigen-1) is implicated in recruitment, retention and activation of leukocytes and its blockade has been referred as a potential target of new drug discovery to address unmet medical needs in inflammatory disease area. In the present study, we investigate the effects of an anti-murine CD49a (integrin α subunit of VLA-1) monoclonal antibody (Ha31/8) on various experimental models of inflammatory diseases in mice. Pretreatment with Ha31/8 at an intraperitoneal dose of 250 µg significantly (P<0...
2016: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/27421127/-pulmonary-involvement-in-connective-tissue-disease
#7
Małgorzata Bartosiewicz
The connective tissue diseases are a variable group of autoimmune mediated disorders characterized by multiorgan damage. Pulmonary complications are common, usually occur after the onset of joint symptoms, but can also be initially presenting complaint. The respiratory system may be involved in all its component: airways, vessels, parenchyma, pleura and respiratory muscles. Lung involvement is an increasing cause of morbidity and mortality in the connective tissue diseases. Clinical course is highly variable - can range from mild to rapidly progressive, some processes are reversible, while others are irreversible...
2016: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/27368035/diffuse-alveolar-damage-in-a-patient-with-rheumatoid-arthritis-under-prolonged-leflunomide-treatment-a-case-report-and-literature-review
#8
Li-Ta Keng, Mong-Wei Lin, Hsien-Neng Huang, Kuei-Pin Chung
Patients with rheumatoid arthritis (RA) often have pulmonary involvement, and interstitial lung disease (ILD) is the primary manifestation, in which diffuse alveolar damage (DAD) is a rare histopathologic pattern. Leflunomide (LEF) is a frequently prescribed disease-modifying antirheumatic drug for treating RA. LEF-related ILD in the form of DAD has been reported in patients with RA, with the duration of LEF treatment before symptom onset ranging from 6 to 1204 days.We present a case of elderly woman with RA under prolonged LEF treatment for >9 years (3291 days), who had acute respiratory failure with the initial presentation of exertional dyspnea, fever, chills, and productive cough for 2 days...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27226666/small-clonal-b-cell-population-in-the-bone-marrow-as-a-possible-tool-in-the-diagnosis-of-occult-primary-parotid-lymphoma
#9
Martha Romero, Guido R González-Fontal, Mónica Duarte, Carlos Saavedra, Andrés F Henao-Martínez
CASE DESCRIPTION: An 82-years old Hispanic woman with a past medical history significant for pulmonary thromboembolism on oral anticoagulation, rheumatoid arthritis, and hypertension developed a new onset thrombocytopenia. CLINICAL FINDINGS: Small clonal B-cells populations (SCBP) also known as monoclonal B-cell lymphocytosis was found as part of the workup for an idiopathic thrombocytopenia and lead ultimately to the diagnosis of parotid primary follicular lymphoma coexisting with Warthin tumor involving the bone marrow in a small extent and oncocytic papilloma located in the maxillary sinus...
2016: Colombia Médica: CM
https://www.readbyqxmd.com/read/27149136/paraneoplastic-scleroderma-are-there-any-clues
#10
Hana Jedlickova, Veronika Durčanská, Vladimír Vašků
Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported. We describe 4 patients with paraneoplastic scleroderma who were treated at the I. Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014. The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland. In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27143819/il-32-a-novel-pluripotent-inflammatory-interleukin-towards-gastric-inflammation-gastric-cancer-and-chronic-rhino-sinusitis
#11
REVIEW
Muhammad Babar Khawar, Muddasir Hassan Abbasi, Nadeem Sheikh
A vast variety of nonstructural proteins have been studied for their key roles and involvement in a number of biological phenomenona. Interleukin-32 is a novel cytokine whose presence has been confirmed in most of the mammals except rodents. The IL-32 gene was identified on human chromosome 16 p13.3. The gene has eight exons and nine splice variants, namely, IL-32α, IL-32β, IL-32γ, IL-32δ, IL-32ε, IL-32ζ, IL-32η, IL-32θ, and IL-32s. It was found to induce the expression of various inflammatory cytokines including TNF-α, IL-6, and IL-1β as well as macrophage inflammatory protein-2 (MIP-2) and has been reported previously to be involved in the pathogenesis and progression of a number of inflammatory disorders, namely, inflammatory bowel disease (IBD), gastric inflammation and cancer, rheumatoid arthritis, and chronic obstructive pulmonary disease (COPD)...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27080864/role-of-cd248-as-a-potential-severity-marker-in-idiopathic-pulmonary-fibrosis
#12
Domokos Bartis, Louise E Crowley, Vijay K D'Souza, Lee Borthwick, Andrew J Fisher, Adam P Croft, Judit E Pongrácz, Richard Thompson, Gerald Langman, Christopher D Buckley, David R Thickett
BACKGROUND: CD248 or Endosialin is a transmembrane molecule expressed in stromal cells binding to extracellular matrix (ECM) components. It has been previously implicated in kidney fibrosis, rheumatoid arthritis as well as in tumour-stromal interactions. This study investigates the role of CD248 in the pathogenesis of fibrotic diseases in Idiopathic Pulmonary Fibrosis (IPF). METHODS: CD248 quantitative immunohistochemistry (IHC) was performed on lung samples from 22 IPF patients and its expression was assayed in cultured pulmonary fibroblasts and epithelial cells...
2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27014276/silica-silicosis-and-autoimmunity
#13
REVIEW
Kenneth Michael Pollard
Inhalation of dust containing crystalline silica is associated with a number of acute and chronic diseases including systemic autoimmune diseases. Evidence for the link with autoimmune disease comes from epidemiological studies linking occupational exposure to crystalline silica dust with the systemic autoimmune diseases systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. Although little is known regarding the mechanism by which silica exposure leads to systemic autoimmune disease, there is a voluminous literature on silica exposure and silicosis that may help identify immune processes that precede development of autoimmunity...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/26989491/yellow-nail-syndrome-in-rheumatoid-arthritis-an-aetiology-beyond-thiol-drugs
#14
Ajay Kumar Mishra, Anu Anna George, Leni George
Yellow nail syndrome (YNS) is a rare entity characterized by a triad of nail changes, lymphoedema and lung involvement. We report a 57-year-old man with rheumatoid arthritis (RA) and YNS. We have reviewed the previous case reports of RA and YNS and discuss the pulmonary manifestations.
March 2016: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/26957528/smoking-and-air-pollution-as-pro-inflammatory-triggers-for-the-development-of-rheumatoid-arthritis
#15
REVIEW
Ronald Anderson, Pieter W A Meyer, Mahmood M T M Ally, Mohammed Tikly
INTRODUCTION: Smoking is now well recognized not only as a risk factor for rheumatoid arthritis (RA), but also as a determinant of disease activity, severity, response to therapy, and possibly mortality. METHODS: Studies, mostly recent, which have provided significant insights into the molecular and cellular mechanisms which underpin the pathogenesis of smoking-related RA, as well as the possible involvement of other types of outdoor and indoor pollution form the basis of this review...
July 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/26933307/pulmonary-involvement-in-rheumatoid-arthritis-a-cross-sectional-study-in-iran
#16
Habib Zayeni, Asghar Haji-Abbasi, Seyed Ali Alavi Foumani, Mehdi Tohidi, Irandokht Shenavar Masooleh, Banafsheh Ghavidel Parsa, Mehrdad Aghaei, Amir Hassankhani, Pooneh Ghavidel Parsa, Alireza Amir Maafi
BACKGROUND: Interstitial lung disease (ILD) is a type of pulmonary manifestation in patients with rheumatoid arthritis (RA). Mostly RA-ILD has no symptoms and is only diagnosed by clinical examination, pulmonary function test (PFT), and high-resolution computed tomography (HRCT); hence it seems that the diagnosis of pulmonary involvement in early stages of RA is of great importance. Therefore, we decided to answer this question whether the evaluation of RA patients without pulmonary symptoms using methods such as PFT and HRCT are justifiable and reasonable or not...
January 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/26912511/management-of-interstitial-lung-disease-associated-with-connective-tissue-disease
#17
REVIEW
Stephen C Mathai, Sonye K Danoff
The lung is a common site of complications of systemic connective tissue disease (CTD), and lung involvement can present in several ways. Interstitial lung disease (ILD) and pulmonary hypertension are the most common lung manifestations in CTD. Although it is generally thought that interstitial lung disease develops later on in CTD it is often the initial presentation ("lung dominant" CTD). ILD can be present in most types of CTD, including rheumatoid arthritis, scleroderma, systemic lupus erythematosus, polymyositis or dermatomyositis, Sjögren's syndrome, and mixed connective tissue disease...
February 24, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/26889492/multiple-pulmonary-cavitary-nodules-with-pyoderma-gangrenosum-in-patient-with-rheumatoid-arthritis
#18
Miae Be, Hee Jeong Cha, Chanho Park, Yongtae Park, Hwasik Jung, Yoeunim Lee, Yangjin Jegal
Pyoderma gangrenosum (PG) is a rare ulcerative neutrophilic disorder of skin. Its pulmonary manifestations are uncommon and only less than forty cases have been reported in the literature previously. PG is associated with variable systemic diseases, most commonly inflammatory bowel disease and hematologic malignancies. It reported rarely in rheumatoid arthritis (RA). We report a case of PG lung involvement in patient with RA associated interstitial lung disease. A 66-year-old woman presented with productive cough and recurrent ulcerative lesion on her left ankle...
January 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/26886389/computed-tomography-of-pulmonary-changes-in-rheumatoid-arthritis-carcinoembryonic-antigen-cea-as-a-marker-of-airway-disease
#19
Milene Caroline Koch, Ivânio Alves Pereira, Luiz Felipe Souza Nobre, Fabricio Souza Neves
Rheumatoid arthritis (RA) classically affects the joints, but can present extra-articular manifestations, including pulmonary disease. The present study aimed to identify possible risk factors or laboratory markers for lung involvement in RA, particularly the presence of rheumatoid factor (RF), anti-citrullinated peptide antibodies (ACPA), and tumor markers, by correlating them with changes observed on chest high-resolution computerized tomography (HRCT). This cross-sectional study involved RA patients who were examined and questioned by a specialist physician and later subjected to chest HRCT and blood collection for measurement of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), ACPA (anti-vimentin and/or anti-CCP3), and the tumor markers carcinoembryonic antigen (CEA), CA 125, CA 15-3, and CA 19-9...
April 2016: Rheumatology International
https://www.readbyqxmd.com/read/26866155/rheumatoid-arthritis-associated-with-pulmonary-fibrosis-in-nigerians-two-case-reports
#20
B O Adefuye, O O Adelowo, P O Adefuye, O O Oguntona
Rheumatoid arthritis may sometimes present with extra-articular involvement, pulmonary involvement is not common. Rheumatoid arthritis has been reported among Nigerians and extra-articular manifestations are rarely seen. One of the patients was misdiagnosed and mismanaged as a patient with pulmonary tuberculosis. The study is to demonstrate that rheumatoid arthritis is not as rare as previously reported in Nigeria and its pulmonary involvement can mimic tuberculosis or other granulomatous lung disorder. Clinical and serological acumen are necessary to distinguish between the two...
September 2014: East African Medical Journal
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