keyword
https://read.qxmd.com/read/38218753/a-new-lymphedema-treatment-using-pyro-drive-jet-injection
#21
JOURNAL ARTICLE
Megumi Nishiyama, Yuko Sakaguchi, Sayuri Morito, Kei Nagase, Takehisa Sakumoto, Kunihiko Yamashita, Mariko Hashiguchi, Makoto Fukuda, Shuji Toda, Shigehisa Aoki
Lymphedema, resulting from impaired lymphatic drainage, causes inflammation, fibrosis and tissue damage leading to symptoms such as limb swelling and restricted mobility. Despite various treatments under exploration, no standard effective therapy exists. Here a novel technique using the pyro-drive jet injection (PJI) was used to create artificial clefts between collagen fibers, which facilitated the removal of excess interstitial fluid. The PJI was used to deliver a mixture of lactated Ringer's solution and air into the tail of animals with secondary skin edema...
January 14, 2024: Human Cell
https://read.qxmd.com/read/38212494/radix-sanguisorbae-improves-intestinal-barrier-in-septic-rats-via-hif-1-%C3%AE-ho-1-f-e2-axis
#22
JOURNAL ARTICLE
Yi-Yan Liu, Dai-Qin Bao, Zi-Sen Zhang, Yu Zhu, Liang-Ming Liu, Tao Li
OBJECTIVE: To investigate whether Radix Sanguisorbae (RS, Diyu) could restore intestinal barrier function following sepsis using a cecal ligation and puncture (CLP)-induced septic rat model and lipopolysaccharide (LPS)-challenged IEC-6 cell model, respectively. METHODS: Totally 224 rats were divided into 4 groups including a control, sham, CLP and RS group according to a random number table. The rats in the control group were administrated with Ringer's lactate solution (30 mL/kg) with additional dopamine [10 µ g/(kg·min)] and given intramuscular injections of cefuroxime sodium (10 mg/kg) 12 h following CLP...
January 12, 2024: Chinese Journal of Integrative Medicine
https://read.qxmd.com/read/38179398/management-of-acute-ferrous-sulfate-poisoning-using-activated-charcoal-monotherapy-a-case-report
#23
Salah Eldin A Abdel Haleem
A 13-year-old schoolgirl presented to a public hospital having ingested over 70 tablets of 65 mg of prescription ferrous sulphate within the last hour. She complained of a 7/10 sharp abdominal pain. Signs included lethargy, agony, diaphoresis, and frequent eructation. Gastrointestinal movements were audible and frequent. Heart rate was at 50 beats per minute with intact but weak pulsations. Blood pressure was at 95/65 mmHg. During the clerking, she started vomiting in pouts separated by few-minute intervals...
December 2023: Curēus
https://read.qxmd.com/read/38164322/a-comparison-between-saline-and-balanced-solutions-in-kidney-transplants-a-randomized-clinical-trial
#24
JOURNAL ARTICLE
Heitor Medeiros, Paulo H Lima, Vital S Junior, Diego A Souza, Aline M Pinheiro, Rand R Martins, Kellen M A H Costa, Jose Hipolito D Junior, Paulo J Medeiros, Wallace A Da Silva
Objective This study aimed to investigate the impact of different types of intravenous fluids - normal saline (NS), lactated Ringer's solution (LR), and PlasmaLyte (PL) - on the acid-base balance and electrolyte concentration following kidney transplant, a common procedure for patients with end-stage renal disease (ESRD). Methodology A randomized controlled trial design was employed, wherein the primary parameters analyzed were postoperative pH and serum potassium levels. Postoperative concentrations of serum bicarbonate, sodium, chloride, and creatinine, as well as graft functionality, were assessed as secondary outcomes...
December 2023: Curēus
https://read.qxmd.com/read/38157984/lowering-cranioplasty-infection-incidence-with-novel-bone-flap-storage-protocol-a-retrospective-cohort-study
#25
JOURNAL ARTICLE
Varun Rao, Noah Burket, Alexei Christodoulides, Christopher Wilson, Chiara A Flores, Jae Hyun Kwon, James Miller, Jamie Bradbury
INTRODUCTION: After craniectomy, autologous bone flaps may be stored using wet or dry cryopreservation. After brain edema subsides, they are replaced during an operation termed "cranioplasty." Cranioplasty is associated with 15% infection incidence. METHODS: We conducted a retrospective comparison of infection outcomes between "wet" and "dry" cryopreservation of cranioplasty bone flaps. Historically, bone flaps were stored utilizing "wet" cryopreservation - bone flap storage in 1 L of Lactated Ringer's solution containing 80mg gentamicin and 2g nafcillin in a sterile plastic container secured in an unsterile plastic bag...
December 27, 2023: World Neurosurgery
https://read.qxmd.com/read/38155325/additional-bicarbonate-infusion-complements-who-rehydration-therapy-in-children-with-acute-diarrhea-and-severe-dehydration-presenting-with-severe-non-anion-gap-metabolic-acidemia-an-open-label-randomized-trial
#26
JOURNAL ARTICLE
Lalit Takia, Arun K Baranwal, Pramod K Gupta, Muralidharan Jayashree, Suresh Kumar Angurana
OBJECTIVES: To assess the efficacy and safety of bicarbonate infusion in children with Acute Diarrhea and Severe Dehydration (ADSD) having severe Non-Anion Gap Metabolic Acidemia (sNAGMA). METHODS: Children (aged 1-144 mo) with ADSD and sNAGMA (pH ≤7.2 and/or serum bicarbonate ≤15 mEq/L) were enrolled in an open-label randomized design. Controls (n = 25) received WHO-recommended rehydration therapy with Ringer Lactate, while intervention group (n = 25) received additional bicarbonate deficit correction...
December 29, 2023: Indian Journal of Pediatrics
https://read.qxmd.com/read/38146499/the-autologous-chondral-platelet-rich-plasma-matrix-implantation-a-new-therapy-in-cartilage-repair-and-regeneration-macroscopic-and-biomechanical-study-in-an-experimental-sheep-model
#27
JOURNAL ARTICLE
Pau Peláez-Gorrea, Elena Damiá-Giménez, Mónica Rubio-Zaragoza, Belén Cuervo-Serrato, Ángel María Hernández-Guerra, Laura Miguel-Pastor, Ayla Del Romero-Martínez, Joaquín Sopena-Juncosa, Marta Torres-Torrillas, Angelo Santana, Ramón Cugat-Bertomeu, José Manuel Vilar-Guereño, Jose Maria Carrillo-Poveda
INTRODUCTION: Articular cartilage injuries are a severe problem, and the treatments for these injuries are complex. The present study investigates a treatment for full-thickness cartilage defects called Autologous Chondral Platelet Rich Plasma Matrix Implantation (PACI) in a sheep model. METHODS: Chondral defects 8 mm in diameter were surgically induced in the medial femoral condyles of both stifles in eight healthy sheep. Right stifles were treated with PACI and an intraarticular injection with a plasma rich in growth factors (PRGF) solution [treatment group (TRT)], while an intraarticular injection of Ringer's lactate solution was administered in left stifles [Control group (CT)]...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/38117095/exchange-transfusion-with-vs-101-a-new-pegylated-hb-designed-to-restore-perfusion-and-increase-o2-carrying-capacity
#28
JOURNAL ARTICLE
William H Nugent, Forest R Sheppard, Kim D Vandegriff, William M Schindler, Ashok Malavalli, Bjorn K Song
Blood products are the current standard for resuscitation of hemorrhagic shock. However, logistical constraints of perishable blood limit availability and pre-hospital use meaning alternatives that provide blood-like responses remain an area of active investigation and development. VS-101 is a new PEGylated human hemoglobin-based oxygen carrier that avoids the logistical hurdles of traditional blood transfusion. This study sought to determine the safety and ability of VS-101 to maintain circulatory function and capillary oxygen delivery in a severe (50%) exchange transfusion (ET) model...
December 13, 2023: Shock
https://read.qxmd.com/read/38105566/comparison-of-six-percent-hydroxyethyl-starch-130-0-4-and-ringer-s-lactate-as-priming-solutions-in-patients-undergoing-isolated-open-heart-valve-surgery-a-double-blind-randomized-controlled-trial
#29
JOURNAL ARTICLE
Behzad Sheikhi, Yousef Rezaei, Farnaz Baghaei Vaji, Mostafa Fatahi, Mehdi Hosseini Yazdi, Ziae Totonchi, Sepideh Banar, Mohammad Mehdi Peighambari, Saeid Hosseini, Carlos-A Mestres
OBJECTIVES: Colloids are added to the priming solution of the cardiopulmonary bypass (CPB) pump to maintain colloid osmotic pressure and prevent fluid overload. This study aimed to compare the effects of 6% hydroxyethyl starch (HES) 130/0.4 and ringer's lactate (RL) priming solution on patients' outcomes undergoing isolated heart valve surgery with CPB. METHODS: This randomized clinical trial included one hundred and 20 patients undergoing heart valve surgery, and those were allocated into two groups...
December 17, 2023: Perfusion
https://read.qxmd.com/read/38101616/a-meta-analysis-of-lactate-ringer-s-solution-versus-normal-saline-in-the-treatment-of-acute-pancreatitis
#30
REVIEW
Zhengwang Wang, Keru Shi, Shaojian Mo, Ziang Liu, Jie Yao
Fluid resuscitation is an important way in the treatment of acute pancreatitis (AP). This meta-analysis aimed to compare the safety and efficacy of Lactate Ringer's solution (LR) and Normal Saline (NS) in the treatment of patients with acute pancreatitis. Searched in PubMed, Web of Science Core Collection (Clarivate), Embase, Cochrane Library, CNKI, China Wanfang, and China VIP database. All randomized controlled clinical trials (RCTs) were identified. 6 studies with 431 patients were included. Compared with NS, LR can significantly reduce the incidence of SIRS at 24 hours, reduce the length of hospitalization, moderate-severe AP, ICU admission and local complications, especially pancreatic necrosis...
December 13, 2023: Gastroenterología y Hepatología
https://read.qxmd.com/read/38084607/effect-of-sodium-bicarbonate-ringer-s-solution-on-lung-injury-in-rats-with-traumatic-hemorrhagic-shock
#31
JOURNAL ARTICLE
Zhenjie Wang, Shugen Xu, Zhaolei Qiu, Chuanming Zheng, Feng Cheng, Lei Li, Zhipeng Xu, Qi Song, Fulong Zhang
This study aimed to explore the impact of different pH values of resuscitation fluid on traumatic hemorrhagic shock (THS), focusing on their effects on glycocalyx and inflammation. A rat model of THS was induced by hemorrhage from a left femur fracture, while an oxygen-glucose deprivation/reoxygenation (OGD/R)-induced HULEC-5a cell model was considered as an in vitro THS model. The lung tissue pathology and glycocalyx structure were assessed through hematoxylin-eosin (H&E) staining and transmission electron microscope examination...
December 12, 2023: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38062206/impact-of-ventriculo-cisternal-irrigation-on-prevention-of-delayed-cerebral-infarction-in-aneurysmal-subarachnoid-hemorrhage-a-single-center-retrospective-study-and-literature-review
#32
REVIEW
Motoyuki Umekawa, Gakushi Yoshikawa
OBJECTIVE: The aim of this study was to evaluate the effectiveness of ventriculo-cisternal irrigation (VCI) in preventing vasospasms and delayed cerebral infarction (DCI) by washing out subarachnoid clots earlier after aneurysm surgery. METHODS: We retrospectively identified 340 subarachnoid hemorrhage (SAH) patients with ruptured intracranial aneurysms treated with postoperative VCI at our institution between December 2010 and January 2020. As VCI therapy, a ventricular drain/cisternal drain was placed during aneurysm surgery, and lactated Ringer's solution was used for irrigation until day 4 of SAH, followed by intracranial pressure control at 5-10 cmH2 O until day 14...
December 8, 2023: Neurosurgical Review
https://read.qxmd.com/read/38059289/high-molecular-weight-linear-polymers-improve-microvascular-perfusion-after-extracorporeal-circulation
#33
JOURNAL ARTICLE
Krianthan Govender, Cynthia Walser, Pedro Cabrales
High molecular weight linear polymers (HMWLP) have earned the name "drag-reducing polymers" due to their ability to reduce drag in turbulent flows. Recently, these polymers have become popular in bioengineering applications. This study investigated whether the addition of HMWLP in a venoarterial extracorporeal circulation (ECC) model could improve microvascular perfusion and oxygenation. Golden Syrian hamsters were instrumented with a dorsal skinfold window chamber and subjected to ECC using a circuit comprising of a peristaltic pump and bubble trap...
December 7, 2023: Journal of Applied Physiology
https://read.qxmd.com/read/38050056/balanced-crystalloids-ringer-s-lactate-versus-normal-saline-in-adults-with-diabetic-ketoacidosis-in-the-emergency-department-brisk-ed-a-pilot-randomised-controlled-trial
#34
RANDOMIZED CONTROLLED TRIAL
Justin W Yan, Ahmed Slim, Kristine Van Aarsen, Yun-Hee Choi, Christopher Byrne, Naveen Poonai, Haley Collins, Kristin K Clemens
BACKGROUND: Current diabetic ketoacidosis (DKA) treatment guidelines recommend using normal saline (NS); however, NS may delay DKA resolution by causing more hyperchloremic metabolic acidosis compared with balanced crystalloids. This study's objective was to determine the feasibility of a future multicentred randomised controlled trial (RCT) comparing intravenous Ringer's lactate (RL) with NS in managing ED patients with DKA. METHODS: We conducted a parallel-arm, triple-blind, pilot RCT of adults (≥18 years) with DKA at a Canadian academic tertiary care ED...
January 22, 2024: Emergency Medicine Journal: EMJ
https://read.qxmd.com/read/38047766/ferroptosis-induced-by-plasma-activated-ringer-s-lactate-solution-prevents-oral-cancer-progression
#35
JOURNAL ARTICLE
Kotaro Sato, Ming Yang, Kae Nakamura, Hiromasa Tanaka, Masaru Hori, Miki Nishio, Akira Suzuki, Hideharu Hibi, Shinya Toyokuni
OBJECTIVE: This study aimed to investigate the effect of plasma-activated Ringer's lactate solution (PAL) on oral squamous cell carcinoma (OSCC) cells and carcinogenic processes with a particular focus on iron and collagenous matrix formation. MATERIALS AND METHODS: We used three OSCC cell lines, one keratinocyte cell line, and two fibroblast lines, and cell viability assays, immunoblotting, flow cytometry, and transmission electron microscopy were performed to evaluate the effect and type of cell death...
December 4, 2023: Oral Diseases
https://read.qxmd.com/read/38042672/effect-of-a-single-intravenous-injection-of-branched-chain-amino-acids-on-body-temperature-of-cats-undergoing-general-anesthesia
#36
JOURNAL ARTICLE
Hisashi Sakata, Stuart C Clark-Price, Aime K Johnson, Susan M Elrod, Erik H Hofmeister
OBJECTIVE: To evaluate the effect of a single intravenous injection of branched chain amino acids (BCAAs) on body temperature in cats undergoing general anesthesia. STUDY DESIGN: Prospective, blinded, randomized, crossover, experimental study. ANIMALS: A total of 10 healthy adult cats (five female and five male). METHODS: Cats were anesthetized three times with three different treatments in a random order: 3 mL kg-1 lactated Ringer's solution (LRS), 100 mg kg-1 BCAAs (B100) or 200 mg kg-1 BCAAs (B200) solution immediately before induction of anesthesia...
November 8, 2023: Veterinary Anaesthesia and Analgesia
https://read.qxmd.com/read/38033223/continuing-medical-education-questions-december-2023
#37
JOURNAL ARTICLE
Ahmed M Dirweesh
Article Title: Lactated Ringers Use in the First 24 Hours of Hospitalization Is Associated with Improved Outcomes in 999 Acute Pancreatitis Patients.
December 1, 2023: American Journal of Gastroenterology
https://read.qxmd.com/read/38025580/peri-operative-management-of-diabetes-mellitus-a-survey-of-current-practices-among-indian-anesthesiologists
#38
JOURNAL ARTICLE
Vansh Priya, Prateek S Bais, Amit Rastogi, Rafat Shamim, Anil Aggarwal, Abinash Patro
BACKGROUND AND AIMS: Increased burden of diabetes in India has resulted in a spurt in the number of patients with diabetes posted for surgeries. The paucity of national guidelines can lead to marked practice variations in the peri-operative management of diabetes. This survey intends to discern current peri-operative practices among anesthesiologists working in medical colleges, tertiary care government, and private health care institutes of the country. MATERIAL AND METHODS: An anonymous online survey comprising of 25 closed-ended questions was conducted using Google Forms® and disseminated through social media, emails, and messaging platforms...
2023: Journal of Anaesthesiology, Clinical Pharmacology
https://read.qxmd.com/read/38025504/end-expiratory-occlusion-test-and-mini-fluid-challenge-test-for-predicting-fluid-responsiveness-in-acute-circulatory-failure
#39
JOURNAL ARTICLE
Velmurugan Selvam, Dilip Shende, Rahul Kumar Anand, Lokesh Kashyap, Bikash Ranjan Ray
INTRODUCTION: Predicting which patients with acute circulatory failure will respond to the fluid by an increase in cardiac output is a daily challenge. End-expiratory occlusion test (EEOT) and mini-fluid challenge (MFC) can be used for assessing fluid responsiveness in patients with spontaneous breathing activity, cardiac arrhythmias, low-tidal volume and/or low lung compliance. METHODS: The objective of the study is to evaluate the value of EEOT and MFC-induced rise in left ventricular outflow tract (LVOT) velocity time integral (VTI) in predicting fluid responsiveness in acute circulatory failure in comparison to the passive leg-raising (PLR) test...
2023: Journal of Emergencies, Trauma, and Shock
https://read.qxmd.com/read/38015322/comparison-of-fluid-resuscitation-with-lactate-ringer-s-versus-normal-saline-in-acute-pancreatitis-an-updated-meta-analysis
#40
JOURNAL ARTICLE
Jiaze Hong, Qingyuan Li, Yiran Wang, Lizhi Xiang, Yifu Zhou, Mengke Fan, Rong Lin
BACKGROUND: Fluid resuscitation is one of the main therapies for acute pancreatitis (AP). There is still no consensus on the type of fluid resuscitation. This study investigated the differences between lactate Ringer's (LR) and normal saline (NS) in treating AP. METHODS: Two authors systematically searched Web of Science, Embase (via OVID), Cochrane Library, and PubMed to find all published research before July, 2023. The odds of moderately severe/severe AP and intensive care unit (ICU) admission are set as primary endpoints...
January 2024: Digestive Diseases and Sciences
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