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https://www.readbyqxmd.com/read/29471480/family-medicine-clinic-a-case-study-of-a-hospital-family-medicine-practice-redesign-to-improve-chronic-disease-care-in-the-community-in-singapore
#1
Yee Wei Lim, Joanna Ling, Zoe Lim, Audrey Chia
Background: Singapore's health care system is strained by the health care needs of a rapidly aging population. The unprecedented collaboration between a public hospital and a private family practice to set up the Family Medicine Clinic (FMC) to co-manage patients with chronic disease is an example of efforts to shift care to the community. Objective: To explore patients' initial experience of shared chronic disease care in a private family practice setting. Methods: In this exploratory case study, we surveyed 330 patients with stable chronic diseases and interviewed 10 complex care patients and their caregivers...
February 17, 2018: Family Practice
https://www.readbyqxmd.com/read/29471342/alternative-treatment-strategies-to-accelerate-the-elimination-of-onchocerciasis
#2
Michel Boussinesq, Grace Fobi, Annette C Kuesel
The use of alternative (or complementary) treatment strategies (ATSs) i.e. differing from annual community-directed treatment with ivermectin (CDTI) is required in some African foci to eliminate onchocerciasis by 2025. ATSs include vector control, biannual or pluriannual CDTI, better timing of CDTI, community-directed treatment with combinations of currently available anthelminthics or new drugs, and 'test-and-treat' (TNT) strategies requiring diagnosis of infection and/or contraindications to treatment for decisions on who to treat with what regimen...
March 1, 2018: International Health
https://www.readbyqxmd.com/read/29471232/changes-in-pro-inflammatory-cytokine-levels-and-late-life-depression-a-two-year-population-based-longitudinal-study
#3
Jae-Min Kim, Robert Stewart, Ju-Wan Kim, Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Jin-Sang Yoon
Longitudinal associations of cytokine levels with depression are unclear. This study aimed to investigate cross-sectional and prospective associations between five serum pro-inflammatory cytokine levels and late-life depression. 732 Korean people aged 65+ were evaluated at baseline. Of 631 without depression (Geriatric Mental State schedule) at baseline, 521 (83%) were followed over a 2 year period and incident depression was ascertained. Serum tumor necrosis factor-α, interleukin (IL)-1α, IL-1β, IL-6, and IL-8 levels were assayed at both baseline and follow-up...
February 14, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29471214/joint-associations-of-%C3%AE-amyloidosis-and-cortical-thickness-with-cognition
#4
David S Knopman, Emily S Lundt, Terry M Therneau, Prashanthi Vemuri, Val J Lowe, Kejal Kantarci, Jeffrey L Gunter, Matthew L Senjem, Michelle M Mielke, Mary M Machulda, Rosebud O Roberts, Bradley F Boeve, David T Jones, Ronald C Petersen, Clifford R Jack
In 1164 cognitively unimpaired persons, aged 50-95 years, from the population-based Mayo Clinic Study of Aging, we examined the relationships of baseline cognition and cognitive changes across the full range of cortical thickness of an Alzheimer signature region of interest and global β-amyloid levels measured by Pittsburgh compound B positron emission tomography (PIB PET) standardized uptake value ratio (SUVR). In machine-learning models accounting for both biomarkers simultaneously, worsening biomarker values were additive and associated with lower baseline global cognition and greater subsequent decline in global cognition...
February 2, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29471199/statistical-modelling-of-fat-oil-and-grease-fog-deposits-in-wastewater-pump-sumps
#5
Eva Nieuwenhuis, Johan Post, Alex Duinmeijer, Jeroen Langeveld, François Clemens
The accumulation of FOG (Fat, Oil and Grease) deposits in sewer pumping stations results in an increase in maintenance costs, malfunctioning of pumps and, a potential increase of wastewater spills in receiving open water bodies. It is thought that a variety of parameters (e.g. geometry of the pump sump, pump operation, socioeconomic parameters of the catchment) influences the built-up of FOG. Based on a database containing data of 126 pumping stations located in five Dutch municipalities a statistical model was built...
February 13, 2018: Water Research
https://www.readbyqxmd.com/read/29471189/concentrations-of-trace-elements-and-pcdd-fs-around-a-municipal-solid-waste-incinerator-in-girona-catalonia-spain-human-health-risks-for-the-population-living-in-the-neighborhood
#6
Joaquim Rovira, Martí Nadal, Marta Schuhmacher, José L Domingo
Previously to the modernization of the municipal solid waste incinerator (MSWI) of Campdorà (Girona, Catalonia, Spain) two sampling campaigns (2015 and 2016) were conducted. In each campaign, 8 soil and 4 air samples (PM10 and total particle phase and gas phase) were collected. The levels of As, Cd, Co, Cr, Cu, Hg, Mn, Ni, Pb, Sb, Sn, Tl and V, and PCDD/Fs were analysed at different distances and wind directions around the MSWI. Environmental levels of trace elements and PCDD/Fs were used to assess exposure and health risks (carcinogenic and non-carcinogenic) for the population living around the facility...
February 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29471188/developing-cross-validating-and-applying-regression-models-to-predict-the-concentrations-of-faecal-indicator-organisms-in-coastal-waters-under-different-environmental-scenarios
#7
Robson V de Souza, Carlos J A Campos, Luis H P Garbossa, Walter Q Seiffert
This study developed, cross-validated and applied a regression-based model to predict concentrations of faecal indicator organisms (FIOs) under different environmental conditions in the North and South bays of Santa Catarina, South of Brazil. The model was developed using a database of FIO concentrations in seawater sampled at 50 sites and the validation was performed using a different database by comparing 288 pairs of measured and modelled results for 15 sites. The index of agreement between the model outputs and the FIO concentrations measured during the validation period was 66%; the mean average error was 0...
February 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29471100/dynamic-fmri-networks-predict-success-in-a-behavioral-weight-loss-program-among-older-adults
#8
Fatemeh Mokhtari, W Jack Rejeski, Yingying Zhu, Guorong Wu, Sean L Simpson, Jonathan H Burdette, Paul J Laurienti
More than one-third of adults in the United States are obese, with a higher prevalence among older adults. Obesity among older adults is a major cause of physical dysfunction, hypertension, diabetes, and coronary heart diseases. Many people who engage in lifestyle weight loss interventions fail to reach targeted goals for weight loss, and most will regain what was lost within 1-2 years following cessation of treatment. This variability in treatment efficacy suggests that there are important phenotypes predictive of success with intentional weight loss that could lead to tailored treatment regimen, an idea that is consistent with the concept of precision-based medicine...
February 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29471016/sensitivity-to-psychosocial-chronic-stressors-and-adolescents-externalizing-problems-combined-moderator-effects-of-resting-heart-rate-and-parental-psychiatric-history
#9
Anna Roos E Zandstra, Johan Ormel, Andrea Dietrich, Edwin R van den Heuvel, Pieter J Hoekstra, Catharina A Hartman
From the literature it is not clear whether low resting heart rate (HR) reflects low or high sensitivity to the detrimental effects of adverse environments on externalizing problems. We studied parental psychiatric history (PH), reflecting general vulnerability, as possible moderator explaining these inconsistencies. Using Linear Mixed Models, we analyzed data from 1914 subjects, obtained in three measurement waves (mean age 11, 13.5, and 16 years) from the TRacking Adolescents' Individual Lives Survey population-based cohort and the parallel clinic-referred cohort...
February 19, 2018: Biological Psychology
https://www.readbyqxmd.com/read/29470544/validation-of-the-what-matters-index-a-brief-patient-reported-index-that-guides-care-for-chronic-conditions-and-can-substitute-for-computer-generated-risk-models
#10
John H Wasson, Lynn Ho, Laura Soloway, L Gordon Moore
INTRODUCTION: Current health care delivery relies on complex, computer-generated risk models constructed from insurance claims and medical record data. However, these models produce inaccurate predictions of risk levels for individual patients, do not explicitly guide care, and undermine health management investments in many patients at lesser risk. Therefore, this study prospectively validates a concise patient-reported risk assessment that addresses these inadequacies of computer-generated risk models...
2018: PloS One
https://www.readbyqxmd.com/read/29470532/psychosocial-health-and-suicidal-ideation-among-people-living-with-hiv-aids-a-cross-sectional-study-in-nanjing-china
#11
Wei Wang, Chenchang Xiao, Xing Yao, Yinmei Yang, Hong Yan, Shiyue Li
BACKGROUND: Suicide is a serious cause of mortality worldwide and is considered as a psychiatric emergency. People living with HIV/AIDS (PLWHA) have higher rates of suicidal behavior than the general population. This study assessed the prevalence and verified the syndemic effect of psychosocial health conditions on suicidal ideation among PLWHA in China. METHODS: An institutional-based cross-sectional study was conducted from July to August 2016 in Nanjing, China, using a self-report questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29470484/the-characteristic-of-asthma-control-among-nasal-diseases-population-results-from-a-cross-sectional-study
#12
Jiangtao Lin, Jie Gao, Kefang Lai, Xin Zhou, Bei He, Jianying Zhou, Changzheng Wang
Asthma affects a large number of patients in China, but comprehensive evaluation of risks associated with poor asthma control in asthmatic patients with nasal diseases was still limited. We conducted this study to provide a comprehensive estimate of asthma control in Chinese asthma patients with combined nasal diseases, to explore the effect of kinds of nasal diseases on the asthma control, and to identify risk factors associated with uncontrolled asthmatic patients with combined nasal diseases. 1756 asthma patients concomitant with nasal diseases aged ≥17 years and representing all regions of mainland China were surveyed...
2018: PloS One
https://www.readbyqxmd.com/read/29470318/cesarean-section-on-the-risk-of-celiac-disease-in-the-offspring-the-teddy-study
#13
Sibylle Koletzko, Hye-Seung Lee, Andreas Beyerlein, Carin A Aronsson, Michael Hummel, Edwin Liu, Ville Simell, Kalle Kurppa, Åke Lernmark, William Hagopian, Marian Rewers, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G Ziegler, Jeffrey Krischer, Daniel Agardh
OBJECTIVE: Cesarean section (C-section) is associated with various immune-mediated diseases in the offspring. We investigated the relationship between mode of delivery and celiac disease (CD) and CD autoimmunity (CDA) in a multinational birth cohort. METHODS: From 2004 to 2010, infants from the general population who tested positive for HLA DR3-DQ2 or DR4-DQ8 were enrolled in The Environmental Determinants for Diabetes in the Young (TEDDY) study. Children were annually screened for transglutaminase autoantibodies, if positive, they are retested after 3 to 6 months and those persistently positive defined as CDA...
March 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29469683/positive-association-between-serum-25-hydroxy-vitamin-d-and-liver-enzymes-levels-in-healthy-individuals-a-population-based-study-from-iran
#14
Leila Nikniaz, Masood Shirmohammadi, Jafar Sadegh Tabrizi, Homayoun Sadeghi Bazargani, Mostafa Farahbakhsh
OBJECTIVE: The relationship between serum 25-hydroxy-vitamin D and within normal range liver enzymes in a population-based study in the northwest of Iran was investigated. METHOD: This cross-sectional study was comprised of 700 apparently healthy Iranian adults (287 men & 413 women) who participated in the major lifestyle promotion project (LPP) conducted in East Azarbaijan-Iran in 2015. The ultraviolet method and chemiluminescent immunoassay technology were respectively used for determination of the serum levels of liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and 25-hydroxy-vitamin D...
February 22, 2018: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/29469682/vitamin-d-supplementation-in-adults-with-vitamin-d-deficiency-and-its-effect-on-metabolic-syndrome-a-randomized-controlled-study
#15
Saba Fathima Mahmood, Jyothi Idiculla, Rajnish Joshi, Shailesh Joshi, Shruthi Kulkarni
BACKGROUND: Inverse relationship between metabolic syndrome (MetS) and 25-hydroxyvitamin D (25(OH) D) levels is controversial. Hypovitaminosis-D has long been suspected as a risk factor for glucose intolerance. AIM: A randomized double blind placebo controlled study to evaluate effects of vitamin D supplementation on insulin resistance in subjects with hypovitaminosis-D and MetS. MATERIALS AND METHODS: Subjects were randomized to receive either oral 25(OH) D3 supplement (60000 (IU) per week for 8 weeks followed by 60,000 IU monthly for 4 months) or a placebo for six months...
February 22, 2018: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/29469042/more-evidence-for-the-genetic-susceptibility-of-mexican-population-to-nonalcoholic-fatty-liver-disease-through-pnpla3
#16
Paulina Chinchilla-López, Oscar Ramírez-Pérez, Vania Cruz-Ramón, Samuel Canizales-Quinteros, Aarón Domínguez-López, Guadalupe Ponciano-Rodríguez, Fausto Sánchez-Muñoz, Nahum Méndez-Sánchez
BACKGROUND: The gene for patatin-like phospholipase domain containing 3 (PNPLA3) is associated with nonalcoholic fatty liver disease (NAFLD) development. We previously found that Mexican indigenous population had the highest frequency reported of the PNPLA3 148M risk allele. Further, we observed a relationship between M148M genotype with elevated ALT levels in individuals with normal weight, overweight and obese. We sought to investigate whether PNPLA3 polymorphism is associated with NAFLD development in Mexicans...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29468986/increased-endothelial-dysfunction-and-insulin-resistance-in-patients-with-klinefelter-syndrome
#17
Cem Haymana, Aydogan Aydogdu, Ibrahim Demirci, Mustafa Dinc, Orhan Demir, Deniz Torun, Fatih Yesildal, Coskun Meric, Yalcın Basaran, Alper Sonmez, Omer Azal
Patients with Klinefelter Syndrome (KS) have increased cardiometabolic risk however the pathogenesis is not clear. We investigated the presence of endothelial dysfunction, insulin resistance and inflammation in an unconfounded population of KS. A total of 32 patients with KS (mean age 21.59 ± 1.66 years) and 33 healthy control subjects (mean age: 22.15 ± 1.03 years) were enrolled. The demographic parameters, Asymmetric dimethylarginine (ADMA), homeostatic model assessment of insulin resistance (HOMA-IR) index and high-sensitivity C-reactive protein (hs-CRP) levels were measured...
February 19, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29468971/il-10-promoter-592-polymorphism-may-influence-resistance-to-hiv-infection-in-south-indian-population
#18
Murugesan Harishankar, Harini Ravikrishnan, Akshaya Ravishankar, Luke Hanna Elizabeth, Soumya Swaminathan, Paramasivam Selvaraj, Ramalingam Bethunaickan
BACKGROUND: Genetic factors play an important role in the development of disease susceptibility or protection. Cytokine gene polymorphisms are reported to be associated with altered levels of cytokine production that can impact disease progression in HIV and TB. OBJECTIVE: In this study, we studied IL-10 -592(C/A) and TGF-β -509 (C/T) promoter polymorphisms to understand their role in susceptibility or resistance to HIV and TB in a South Indian population. METHOD: Genomic DNA was isolated from healthy controls, pulmonary tuberculosis patients (n=122) and HIV positive individuals (n=100) and used for genotyping by polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) method...
February 19, 2018: Current HIV Research
https://www.readbyqxmd.com/read/29468953/socioeconomic-differences-in-the-use-of-alcohol-and-drunkenness-in-adolescents-trends-in-the-health-behaviour-in-school-aged-children-study-in-finland-1990-2014
#19
Yang Liu, Tomi Lintonen, Jorma Tynjälä, Jari Villberg, Raili Välimaa, Kristiina Ojala, Lasse Kannas
AIMS: The aims of this study were to explore time-based trends of socioeconomic differences in alcohol use and drunkenness in Finnish adolescents from 1990 to 2014 and to investigate the significance of two indicators in detecting socioeconomic differences in alcohol use and drunkenness. METHODS: Data were retrieved from seven surveys conducted as part of the Health Behaviour in School-aged Children (HBSC) study in Finland from 1990 to 2014. The alcohol use and drunkenness of 15-year-old students, as well as socioeconomic status, including educational aspiration and perceived family wealth, were assessed via a self-report questionnaire...
February 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29468775/spatiotemporal-incidence-rate-data-analysis-by-nonparametric-regression
#20
Kai Yang, Peihua Qiu
To monitor the incidence rates of cancers, AIDS, cardiovascular diseases, and other chronic or infectious diseases, some global, national, and regional reporting systems have been built to collect/provide population-based data about the disease incidence. Such databases usually report daily, monthly, or yearly disease incidence numbers at the city, county, state, or country level, and the disease incidence numbers collected at different places and different times are often correlated, with the ones closer in place or time being more correlated...
February 21, 2018: Statistics in Medicine
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