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https://www.readbyqxmd.com/read/29244841/individual-preferences-for-physical-exercise-as-secondary-prevention-for-non-specific-low-back-pain-a-discrete-choice-experiment
#1
Emmanuel Aboagye, Jan Hagberg, Iben Axén, Lydia Kwak, Malin Lohela-Karlsson, Eva Skillgate, Gunilla Dahlgren, Irene Jensen
BACKGROUND: Exercise is effective in improving non-specific low back pain (LBP). Certain components of physical exercise, such as the type, intensity and frequency of exercise, are likely to influence participation among working adults with non-specific LBP, but the value and relative importance of these components remain unknown. The study's aim was to examine such specific components and their influence on individual preferences for exercise for secondary prevention of non-specific LBP among working adults...
2017: PloS One
https://www.readbyqxmd.com/read/29244822/alcohol-consumption-and-breast-cancer-specific-and-all-cause-mortality-in-women-diagnosed-with-breast-cancer-at-the-new-york-site-of-the-breast-cancer-family-registry
#2
Nur Zeinomar, Ashley Thai, Ann J Cloud, Jasmine A McDonald, Yuyan Liao, Mary Beth Terry
PURPOSE: Alcohol consumption is an established and important risk factor for breast cancer incidence in the general population. However, the relationship between alcohol and mortality among women with breast cancer is less clear. This study examines the effect of alcohol consumption on mortality in women affected with breast cancer at baseline from a high-risk family breast and ovarian cancer registry. METHODS: We studied 1116 women affected with breast cancer at baseline from the Metropolitan New York Registry...
2017: PloS One
https://www.readbyqxmd.com/read/29244810/synaptic-augmentation-in-a-cortical-circuit-model-reproduces-serial-dependence-in-visual-working-memory
#3
Daniel P Bliss, Mark D'Esposito
Recent work has established that visual working memory is subject to serial dependence: current information in memory blends with that from the recent past as a function of their similarity. This tuned temporal smoothing likely promotes the stability of memory in the face of noise and occlusion. Serial dependence accumulates over several seconds in memory and deteriorates with increased separation between trials. While this phenomenon has been extensively characterized in behavior, its neural mechanism is unknown...
2017: PloS One
https://www.readbyqxmd.com/read/29244775/spatial-temporal-and-dietary-variables-associated-with-elevated-mercury-exposure-in-peruvian-riverine-communities-upstream-and-downstream-of-artisanal-and-small-scale-gold-mining
#4
Lauren Wyatt, Ernesto J Ortiz, Beth Feingold, Axel Berky, Sarah Diringer, Ana Maria Morales, Elvis Rojas Jurado, Heileen Hsu-Kim, William Pan
Artisanal and small-scale gold mining (ASGM) is a primary contributor to global mercury and its rapid expansion raises concern for human exposure. Non-occupational exposure risks are presumed to be strongly tied to environmental contamination; however, the relationship between environmental and human mercury exposure, how exposure has changed over time, and risk factors beyond fish consumption are not well understood in ASGM settings. In Peruvian riverine communities (n = 12), where ASGM has increased 4-6 fold over the past decade, we provide a large-scale assessment of the connection between environmental and human mercury exposure by comparing total mercury contents in human hair (2-cm segment, n = 231) to locally caught fish tissue, analyzing temporal exposure in women of child bearing age (WCBA, 15-49 years, n = 46) over one year, and evaluating general mercury exposure risks including fish and non-fish dietary items through household surveys and linear mixed models...
December 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29244556/seasonal-food-scarcity-prompts-long-distance-foraging-by-a-wild-social-bee
#5
Nathaniel S Pope, Shalene Jha
Foraging is an essential process for mobile animals, and its optimization serves as a foundational theory in ecology and evolution; however, drivers of foraging are rarely investigated across landscapes and seasons. Using a common bumblebee species from the western United States (Bombus vosnesenskii), we ask whether seasonal decreases in food resources prompt changes in foraging behavior and space use. We employ a unique integration of population genetic tools and spatially explicit foraging models to estimate foraging distances and rates of patch visitation for wild bumblebee colonies across three study regions and two seasons...
January 2018: American Naturalist
https://www.readbyqxmd.com/read/29244218/person-specific-contribution-of-neuropathologies-to-cognitive-loss-in-old-age
#6
Patricia A Boyle, Lei Yu, Robert S Wilson, Sue E Leurgans, Julie A Schneider, David A Bennett
OBJECTIVE: Mixed neuropathologies are the most common cause of dementia at the population level, but how different neuropathologies contribute to cognitive decline at the individual level remains unknown. We quantified the contribution of nine neuropathologies to cognitive loss at an individual level. METHODS: Participants (n=1,079) came from 2 longitudinal clinical-pathologic studies of aging. All completed 2+ cognitive evaluations (maximum = 22), died and underwent neuropathologic examinations to identify Alzheimer's disease (AD), other neurodegenerative diseases, and vascular pathologies...
December 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29243850/serum-pepsinogen-1-and-anti-helicobacter-pylori-igg-antibodies-as-predictors-of-gastric-cancer-risk-in-finnish-males
#7
M Song, M C Camargo, S J Weinstein, G Murphy, N D Freedman, J Koshiol, R Z Stolzenberg-Solomon, C C Abnet, S Männistö, D Albanes, C S Rabkin
BACKGROUND: Serum pepsinogen 1 (SPG1) and anti-Helicobacter pylori serology have been used for gastric risk stratification in Asia. AIM: To assess utility of these markers in a Western population. METHODS: SPG1 measurements were available for 21 895 Finnish male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. We used Cox proportional hazards models adjusted for potential confounders to estimate gastric cancer hazard ratios (HR) and 95% confidence intervals (95% CI) for low SPG1 (<25 μg/L)...
December 15, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29243550/attention-deficit-hyperactivity-disorder-is-associated-with-reduced-levels-of-serum-low-density-lipoprotein-cholesterol-in-adolescents-data-from-the-population-based-german-kiggs-study
#8
Raquel Pinho, Biyao Wang, Andreas Becker, Aribert Rothenberger, Tiago F Outeiro, Christoph Herrmann-Lingen, Thomas Meyer
OBJECTIVES: Attention-deficit/hyperactivity disorder (ADHD) is a multifactorial, complex and the most common neurodevelopmental disorder in childhood. In this analysis, we tested the hypothesis that altered serum lipid patterns are associated with ADHD. METHODS: Using data from the nationwide, population-based German Health Interview and Examination Survey for Children and Adolescents (KiGGS), we compared serum levels of total cholesterol, high-density (HDL) and low-density lipoprotein (LDL) cholesterol, and also triglycerides, in participants with physician-diagnosed and/or suspected ADHD, as defined by a value of ≥7 on the hyperactivity-inattention subscale of the Strengths and Difficulties Questionnaire (SDQ), with non-ADHD controls...
December 15, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29243539/the-influence-of-neighbor-effect-and-urbanization-toward-organ-donation-in-thailand
#9
Kua Wongboonsin, Pavitra Jindahra, Surat Teerakapibal
INTRODUCTION: Toward population wellness, an extreme scarcity of organ supply is proven to be an enormous hindrance. Preferences toward organ donation are vital to raise the organ donation rate. Notably, the area people live in can address the social influence on individual preference toward organ donation. RESEARCH QUESTIONS: This article studies the impact of the neighbor effect on organ donation decisions, addressing the social influence of urbanization on preferences...
January 1, 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29243347/cost-effectiveness-of-increasing-the-reach-of-smoking-cessation-interventions-in-germany-results-from-the-equiptmod
#10
Manuel B Huber, Maximilian Präger, Kathryn Coyle, Doug Coyle, Adam Lester-George, Marta Trapero-Bertran, Bertalan Nemeth, Kei Long Cheung, Renee Stark, Matthias Vogl, Subhash Pokhrel, Reiner Leidl
AIMS: To evaluate costs, effects and cost-effectiveness of increased reach of specific smoking cessation interventions in Germany. DESIGN: A Markov-based state transition return on investment model (EQUIPTMOD) was used to evaluate current smoking cessation interventions as well as two prospective investment scenarios. A health-care perspective (extended to include out-of-pocket payments) with life-time horizon was considered. A probabilistic analysis was used to assess uncertainty concerning predicted estimates...
December 15, 2017: Addiction
https://www.readbyqxmd.com/read/29243239/evaluation-of-australian-surveillance-for-freedom-from-bovine-tuberculosis
#11
Esg Sergeant, J Happold, I Langstaff
BACKGROUND: Australia declared freedom from bovine tuberculosis (TB) in accordance with international guidelines in 1997 and has since maintained ongoing surveillance for this disease, primarily through abattoir surveillance of cattle carcases (meat inspection) for TB-like granulomas. The objectives of this study were to estimate the sensitivity of Australia's surveillance system and quantify the probability that Australia is free from bovine TB at the specified design prevalence. METHODS: The analysis included approximately 80 million records of individual cattle slaughtered and meat inspected at Australian abattoirs between 2005 and 2015 calendar years...
December 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29243222/population-modeling-of-tumor-kinetics-and-overall-survival-to-identify-prognostic-and-predictive-biomarkers-of-efficacy-for-durvalumab-in-patients-with-urothelial-carcinoma
#12
Yanan Zheng, Rajesh Narwal, ChaoYu Jin, Paul G Baverel, Xiaoping Jin, Ashok Gupta, Yong Ben, Bing Wang, Pralay Mukhopadhyay, Brandon W Higgs, Lorin Roskos
Durvalumab is an anti-PD-L1 monoclonal antibody approved for patients with locally advanced or metastatic urothelial carcinoma (UC) that has progressed after platinum-containing chemotherapy. A population tumor kinetic model, coupled with dropout and survival models, was developed to describe longitudinal tumor size data and predict overall survival in UC patients treated with durvalumab (NCT01693562) and to identify prognostic and predictive biomarkers of clinical outcomes. Model-based covariate analysis identified liver metastasis as the most influential factor for tumor growth and immune-cell PD-L1 expression and baseline tumor burden as predictive factors for tumor killing...
December 15, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29242096/risk-factors-for-short-term-complications-after-rotator-cuff-repair-in-the-united-states
#13
William W Schairer, Benedict U Nwachukwu, Michael C Fu, Russell F Warren
PURPOSE: To use a population-level dataset to evaluate the rate of 30-day complications after rotator cuff repair, and to evaluate the risk factors for complication and unplanned hospital readmission. METHODS: We used the American College of Surgeons National Surgical Quality Improvement Program from 2011 to 2015 to identify patients who underwent rotator cuff repair and concomitant procedures using Current Procedural Terminology codes. Postoperative complications and unplanned hospital readmissions were identified...
December 11, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29241646/hiv-population-level-adaptation-can-rapidly-diminish-the-impact-of-a-partially-effective-vaccine
#14
Joshua T Herbeck, Kathryn Peebles, Paul T Edlefsen, Morgane Rolland, James T Murphy, Geoffrey S Gottlieb, Neil Abernethy, James I Mullins, John E Mittler, Steven M Goodreau
BACKGROUND: Development of an HIV vaccine might be essential to ending the HIV/AIDS pandemic. However, vaccines can result in the emergence and spread of vaccine-resistant strains. Indeed, analyses of breakthrough infections in the HIV phase 3 vaccine trial RV144 identified HIV genotypes with differential rates of transmission in vaccine and placebo recipients. We hypothesized that, for HIV vaccination programs based on partially effective vaccines similar to RV144, HIV adaptation will rapidly diminish the expected vaccine impact...
December 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29241637/-health-and-determinants-of-health-in-second-generations-of-international-immigrants-social-inequalities-in-health-since-childhood
#15
Yolanda González-Rábago, Unai Martín
OBJECTIVE: To analyse the social inequalities in health between children and youth population of an immigrant origin from low-income countries and those of native origin in the Basque Country. METHOD: Cross-sectional descriptive study using data from the Basque Country Health Survey 2013. Variables of health, behaviours and life conditions were used as the outcome variables. Prevalence ratios were calculated using robust Poisson models. RESULTS: The children with immigrant parents had poorer self-rated health, a higher prevalence of obesity, spent more hours in sedentary activities and lived in households with greater economic difficulties...
December 11, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29241433/long-run-trends-in-antidepressant-use-among-youths-after-the-fda-black-box-warning
#16
Nilay Kafali, Ana Progovac, Sherry Shu-Yeu Hou, Benjamin Lê Cook
OBJECTIVE: In October 2004, the Food and Drug Administration directed pharmaceutical companies to issue a black box warning about the potential link between the use of antidepressants and suicidal ideation among children. This study analyzed long-run trends in antidepressant use among children before and after the black box warning for those with and without severe psychological impairment. METHODS: The analysis used data from the Medical Expenditure Panel Survey for children ages five to 17, covering years 2000-2011 (N=75,819)...
December 15, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29241065/associations-between-maternal-triclosan-concentrations-in-early-pregnancy-and-gestational-diabetes-mellitus-impaired-glucose-tolerance-gestational-weight-gain-and-fetal-markers-of-metabolic-function
#17
Gabriel D Shapiro, Tye E Arbuckle, Jillian Ashley-Martin, William D Fraser, Mandy Fisher, Maryse F Bouchard, Patricia Monnier, Anne-Sophie Morisset, Adrienne S Ettinger, Linda Dodds
BACKGROUND: Triclosan is a phenolic biocide used in a multitude of consumer products and in health care settings. It is widely detected in the American and Canadian populations and has been shown in animal models to act as an endocrine disrupting agent. However, there has been little examination to date of the effects of triclosan exposure in pregnancy on perinatal metabolic outcomes in human populations. METHODS: Using data from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a Canadian pregnancy cohort, we measured associations of first-trimester urinary triclosan concentrations with total gestational weight gain, gestational diabetes mellitus and impaired glucose tolerance in pregnancy, and fetal markers of metabolic function...
December 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/29240670/well-being-and-associated-factors-among-women-in-the-gender-segregated-country
#18
Hoda Jradi, Oraynab Abouabbas
Well-being is an essential measure that contributes to the evaluation of the health and quality of life of populations. In 1948, the World Health Organization (WHO) defined health as physical, mental and social well-being. A cross-sectional survey was conducted in Riyadh, Saudi Arabia, between July and September 2015. Women aged 18 years old and above were invited to participate in the study. The data were collected using the WHO's Well-Being Index questionnaire. Univariate and multivariate logistic regression models were fitted to identify factors that are significantly associated with well-being...
December 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29240232/trends-in-self-reported-oral-health-of-us-adults-national-health-and-nutrition-examination-survey-1999-2014
#19
Kar Yan Li, Christopher E Okunseri, Colman McGrath, May C M Wong
OBJECTIVE: Single-item self-reported oral health (SROH) is a convenient and reliable measure for the assessment of population-based oral health. However, little is known about trends and its associations among US adults. This study investigated trends in SROH (aged 20+ years) and the associated factors among adults living in the United States. METHODS: Self-reported oral health data for 41 621 adults aged 20+ years from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2014 were analysed...
December 14, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29239587/redefining-medical-care
#20
Lauren R Roth
President Donald J. Trump has said he will repeal the Affordable Care Act (ACA) and replace it with health savings accounts (HSAs). Conservatives have long preferred individual accounts to meet social welfare needs instead of more traditional entitlement programs. The types of "medical care" that can be reimbursed through an HSA are listed in section 213(d) of the Internal Revenue Code (Code) and include expenses "for the diagnosis, cure, mitigation, treatment, or prevention of disease, or for the purpose of affecting any structure or function of the body...
2017: Cornell Journal of Law and Public Policy
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