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https://www.readbyqxmd.com/read/29691071/incidence-determinants-and-clinical-impact-of-definite-stent-thrombosis-on-mortality-in-women-from-the-win-des-collaborative-patient-level-pooled-analysis
#1
Laura S Kerkmeijer, Bimmer E Claessen, Usman Baber, Samantha Sartori, Jaya Chandrasekhar, Giulio G Stefanini, Gregg W Stone, P Gabriel Steg, Alaide Chieffo, Giora Weisz, Stephan Windecker, Ghada W Mikhail, Adnan Kastrati, Marie-Claude Morice, George D Dangas, Robbert J de Winter, Roxana Mehran
BACKGROUND: Predictors and clinical outcomes of stent thrombosis (ST) in women have not been well investigated. Present study aimed to identify predictors of definite ST and its impact on mortality in women undergoing percutaneous coronary intervention (PCI). METHODS: Patient-level data of women enrolled in 26 randomized trials of DES was pooled. The study population was stratified based on the presence or absence of definite ST. Cox proportional hazards models were used to determine the predictors of definite ST...
April 12, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29690884/capsaicin-enriched-diet-ameliorates-autoimmune-neuritis-in-rats
#2
Jeremias Motte, Björn Ambrosius, Thomas Grüter, Hussein Bachir, Melissa Sgodzai, Xiomara Pedreiturria, Kalliopi Pitarokoili, Ralf Gold
BACKGROUND: Autoimmune neuropathies are common PNS disorders and effective treatment is challenging. Environmental influence and dietary components are known to affect the course of autoimmune diseases. Capsaicin as pungent component of chili-peppers is common in human nutrition. An influence of capsaicin on autoimmune diseases has been postulated. METHODS: We tested capsaicin in the animal model of experimental autoimmune neuritis (EAN) in Lewis rat. Rats were immunized with P2-peptide and were treated with capsaicin in different preventive settings...
April 24, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29690614/cytokine-expression-and-macrophage-localization-in-xenograft-and-allograft-tumor-models-stimulated-with-lipopolysaccharide
#3
Junko Masuda, Tsukasa Shigehiro, Takuma Matsumoto, Ayano Satoh, Akifumi Mizutani, Chiho Umemura, Shoki Saito, Mayumi Kijihira, Eiji Takayama, Akimasa Seno, Hiroshi Murakami, Masaharu Seno
T cell-deficient mice such as nude mice are often used to generate tumor xenograft for the development of anticancer agents. However, the functionality of the other immune cells including macrophages, dendritic cells (DCs), and myeloid-derived suppressor cells (MDSCs) in the xenograft are largely unknown. Macrophages and dendritic cells (DCs) acquire functionally distinct properties in response to various environmental stimuli; the interaction of these cells with MDSCs in tumor microenvironments regulates cancer progression...
April 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29690535/projection-of-future-mortality-due-to-temperature-and-population-changes-under-representative-concentration-pathways-and-shared-socioeconomic-pathways
#4
Jae Young Lee, Ejin Kim, Woo-Seop Lee, Yeora Chae, Ho Kim
The Paris Agreement aims to limit the global temperature increase to below 2 °C above pre-industrial levels and to pursue efforts to limit the increase to even below 1.5 °C. Now, it should be asked what benefits are in pursuing these two targets. In this study, we assessed the temperature⁻mortality relationship using a distributed lag non-linear model in seven major cities of South Korea. Then, we projected future temperature-attributable mortality under different Representative Concentration Pathway (RCP) and Shared Socioeconomic Pathway (SSP) scenarios for those cities...
April 21, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29689465/two-way-effect-modifications-of-air-pollution-and-air-temperature-on-total-natural-and-cardiovascular-mortality-in-eight-european-urban-areas
#5
Kai Chen, Kathrin Wolf, Susanne Breitner, Antonio Gasparrini, Massimo Stafoggia, Evangelia Samoli, Zorana Jovanovic Andersen, Getahun Bero-Bedada, Tom Bellander, Frauke Hennig, Bénédicte Jacquemin, Juha Pekkanen, Regina Hampel, Josef Cyrys, Annette Peters, Alexandra Schneider
BACKGROUND: Although epidemiological studies have reported associations between mortality and both ambient air pollution and air temperature, it remains uncertain whether the mortality effects of air pollution are modified by temperature and vice versa. Moreover, little is known on the interactions between ultrafine particles (diameter ≤ 100 nm, UFP) and temperature. OBJECTIVE: We investigated whether the short-term associations of particle number concentration (PNC in the ultrafine range (≤100 nm) or total PNC ≤ 3000 nm, as a proxy for UFP), particulate matter ≤ 2...
April 21, 2018: Environment International
https://www.readbyqxmd.com/read/29689080/beyond-syndromic-management-opportunities-for-diagnosis-based-treatment-of-sexually-transmitted-infections-in-low-and-middle-income-countries
#6
Nigel J Garrett, Farzana Osman, Bhavna Maharaj, Nivashnee Naicker, Andrew Gibbs, Emily Norman, Natasha Samsunder, Hope Ngobese, Nireshni Mitchev, Ravesh Singh, Salim S Abdool Karim, Ayesha B M Kharsany, Koleka Mlisana, Anne Rompalo, Adrian Mindel
INTRODUCTION: In light of the limited impact the syndromic management approach has had on the global sexually transmitted infection (STI) epidemic, we assessed a care model comprising point-of-care (POC) STI testing, immediate treatment, and expedited partner therapy (EPT) among a cohort of young women at high HIV risk in South Africa. METHODS AND FINDINGS: HIV negative women presenting for STI care underwent POC testing for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV), and swabs were sent for NG culture and susceptibility testing...
2018: PloS One
https://www.readbyqxmd.com/read/29688759/relations-between-the-residential-fast-food-environment-and-the-individual-risk-of-cardiovascular-diseases-in-the-netherlands-a-nationwide-follow-up-study
#7
Maartje Poelman, Maciej Strak, Oliver Schmitz, Gerard Hoek, Derek Karssenberg, Marco Helbich, Anna-Maria Ntarladima, Michiel Bots, Bert Brunekreef, Rick Grobbee, Martin Dijst, Ilonca Vaartjes
Background The food environment has been hypothesized to influence cardiovascular diseases such as hypertension and coronary heart disease. This study determines the relation between fast-food outlet density (FFD) and the individual risk for cardiovascular disease, among a nationwide Dutch sample. Methods After linkage of three national registers, a cohort of 2,472,004 adults (≥35 years), free from cardiovascular disease at January 1st 2009 and living at the same address for ≥15 years was constructed. Participants were followed for one year to determine incidence of cardiovascular disease, including coronary heart disease, stroke and heart failure...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29688421/differential-effect-of-selection-against-line-retrotransposons-among-vertebrates-inferred-from-whole-genome-data-and-demographic-modeling
#8
Alexander T Xue, Robert P Ruggiero, Michael J Hickerson, Stéphane Boissinot
Variation in LINE composition is one of the major determinants for the substantial size and structural differences among vertebrate genomes. In particular, the larger genomes of mammals are characterized by hundreds of thousands of copies from a single LINE clade, L1, whereas non-mammalian vertebrates possess a much greater diversity of LINEs, yet with orders of magnitude less in copy number. It has been proposed that such variation in copy number among vertebrates is due to differential effect of LINE insertions on host fitness...
April 23, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29688419/clinical-impact-of-direct-stenting-and-interaction-with-thrombus-aspiration-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-percutaneous-coronary-intervention-thrombectomy-trialists-collaboration
#9
Karim D Mahmoud, Sanjit S Jolly, Stefan James, Vladimír Džavík, John A Cairns, Goran K Olivecrona, Henrik Renlund, Peggy Gao, Bo Lagerqvist, Ashraf Alazzoni, Sasko Kedev, Goran Stankovic, Brandi Meeks, Ole Frøbert, Felix Zijlstra
Aims: Preliminary studies suggest that direct stenting (DS) during percutaneous coronary intervention (PCI) may reduce microvascular obstruction and improve clinical outcome. Thrombus aspiration may facilitate DS. We assessed the impact of DS on clinical outcome and myocardial reperfusion and its interaction with thrombus aspiration among ST-segment elevation myocardial infarction (STEMI) patients undergoing PCI. Methods and results: Patient-level data from the three largest randomized trials on routine manual thrombus aspiration vs...
April 21, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29688320/limited-english-proficiency-and-trajectories-of-depressive-symptoms-among-mexican-american-older-adults
#10
Giyeon Kim, Minjung Kim, Soohyun Park, Daniel E Jimenez, David A Chiriboga
Background and Objectives: This study examined the effect of limited English proficiency (LEP) on trajectories of depressive symptoms among Mexican American older adults in the United States. Research Design and Methods: The sample was drawn from Waves 1 to 6 (1993-2007) of the Hispanic Established Population for Epidemiological Studies of the Elderly (H-EPESE). A total of 2,945 Mexican American older adults were included in the analyses. A latent growth curve modeling was conducted...
April 23, 2018: Gerontologist
https://www.readbyqxmd.com/read/29687883/optimists-or-realists-how-ants-allocate-resources-in-making-reproductive-investments
#11
Brittany L Enzmann, Peter Nonacs
1.Parents often face an investment trade-off between either producing many small or fewer large offspring. When environments vary predictably, the fittest parental solution matches available resources by varying only number of offspring and never optimal individual size. However when mismatches occur often between parental expectations and true resource levels, dynamic models like multifaceted parental investment (MFPI) and parental optimism (PO) both predict offspring size can vary significantly. MFPI is a "realist" strategy: parents assume future environments of average richness...
April 24, 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29687872/ikk%C3%AE%C2%B5-aggravates-inflammatory-response-via-phosphorylation-of-erk-in-rheumatoid-arthritis
#12
L-F Zhou, W Zeng, L-C Sun, Y Wang, F Jiang, X Li, Y Zheng, G-M Wu
OBJECTIVE: Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease, whereas its cause still remains elusive. Typical pathological manifestations of RA include persistent synovitis and bone degeneration in the surrounding joints. Although the incidence of RA is high in population, currently there have been no effective cures for it. The purpose of this study is to investigate the therapeutic effects and main mechanism of IKKε (inhibitor of nuclear factor kappa-B kinase ε) in collagen II induced- Rheumatoid Arthritis (CIA) mice model...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687748/magnetic-resonance-conditional-paramagnetic-choke-for-suppression-of-imaging-artifacts-during-magnetic-resonance-imaging
#13
Kevin J Wu, T Stan Gregory, Brian L Boland, Wujun Zhao, Rui Cheng, Leidong Mao, Zion Tsz Ho Tse
Higher risk patient populations require continuous physiological monitoring and, in some cases, connected life-support systems, during magnetic resonance imaging examinations. While recently there has been a shift toward wireless technology, some of the magnetic resonance imaging devices are still connected to the outside using cabling that could interfere with the magnetic resonance imaging's radio frequency during scanning, resulting in excessive heating. We developed a passive method for radio frequency suppression on cabling that may assist in making some of these devices magnetic resonance imaging compatible...
April 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29687651/tlr9-deficiency-breaks-tolerance-to-rna-associated-antigens-and-upregulates-tlr7-protein-in-sle1-mice
#14
Teja Celhar, Hiroko Yasuga, Hui-Yin Lee, Olga Zharkova, Shubhita Tripathi, Susannah I Thornhill, Hao K Lu, Bijin Au, Lina H K Lim, Thomas P Thamboo, Shizuo Akira, Edward K Wakeland, John E Connolly, Anna-Marie Fairhurst
OBJECTIVE: Toll-like receptors (TLRs) 7 and 9 are important innate signaling molecules with opposing roles in the development and progression of Systemic Lupus Erythematosus (SLE). While multiple studies support a dependency on TLR7 for disease development, genetic ablation of TLR9 results in severe disease with glomerulonephritis (GN) by a largely unknown mechanism. The present study was designed to examine the suppressive role of TLR9 in the development of severe lupus. METHODS: We crossed Sle1 lupus-prone mice with TLR9-deficient mice to generate Sle1TLR9-/- ...
April 24, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29686968/circulating-pander-concentration-is-associated-with-increased-hba1c-and-fasting-blood-glucose-in-type-2-diabetic-subjects
#15
Catherine B MarElia, Melanie N Kuehl, Tiffany A Shemwell, Amy C Alman, Brant R Burkhardt
Aim: PANcreatic-DERived factor (PANDER, FAM3B) is a novel hormone that regulates glucose levels via interaction with both the endocrine pancreas and liver. Prior studies examining PANDER were primarily conducted in murine models or in vitro but little is known regarding the circulating concentration of PANDER in humans, especially with regard to the association of type 2 diabetes (T2D) or overall glycemic regulation. To address this limitation, we performed a cross-sectional analysis of circulating serum PANDER concentration in association with other hormones that serve as either markers of insulin resistance (insulin and adiponectin) or to metabolic parameters of glycemic control such as fasting HbA1c and blood glucose (FBG)...
March 2018: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29686863/fat-soluble-vitamins-a-and-e-and-health-disparities-in-a-cohort-of-pregnant-women-at-delivery
#16
Corrine Hanson, Marina Verdi Schumacher, Elizabeth Lyden, Dejun Su, Jeremy Furtado, Rex Cammack, Bradley Bereitschaft, Matthew Van Ormer, Howard Needelman, Elizabeth McGinn, Katherine Rilett, Caleb Cave, Rebecca Johnson, Kara Weishaar, Ann Anderson-Berry
The objective of the present study was to evaluate intakes and serum levels of vitamin A, vitamin E, and related compounds in a cohort of maternal-infant pairs in the Midwestern USA in relation to measures of health disparities. Concentrations of carotenoids and tocopherols in maternal serum were measured using HPLC and measures of socio-economic status, including food security and food desert residence, were obtained in 180 mothers upon admission to a Midwestern Academic Medical Center labour and delivery unit...
2018: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29686841/effects-of-the-tanaka-line-on-the-genetic-structure-of-bombax-ceiba-malvaceae-in-dry-hot-valley-areas-of-southwest-china
#17
Miao-Miao Ju, Yi Fu, Gui-Fang Zhao, Cheng-Zhong He, Zhong-Hu Li, Bin Tian
Southwest China is an important biodiversity hotspot. The interactions among the complex topography, climate change, and ecological factors in the dry-hot valley areas in southwest China may have profoundly affected the genetic structure of plant species in this region. In this study, we determined the effects of the Tanaka Line on genetic variation in the wild Bombax ceiba tree in southwest China. We sampled 224 individuals from 17 populations throughout the dry-hot valley regions. Six polymorphic expressed sequence tag-simple sequence repeat primers were employed to sequence the PCR products using the first-generation Sanger technique...
April 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29686781/salivary-metals-age-and-gender-correlate-with-cultivable-oral-candida-carriage-levels
#18
Hannah L Norris, Justin Friedman, Ziqiang Chen, Sumant Puri, Gregory Wilding, Mira Edgerton
Background : Little is known about the normal range of metal levels in unstimulated saliva, nor whether these might impact Candida carriage in healthy individuals. Both are important in determining which populations are at risk for candidiasis, as the availability of metal ions can influence the growth and pathogenesis of Candida albicans . Objective : We quantified salivary metals of healthy individuals to determine the correlation with C. albicans oral colonization. Design : Unstimulated whole saliva was collected from healthy adults and plated to determine fungal carriage, and metal content was measured using ICP-mass spectrometry (ICP-MS)...
2018: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29686613/essential-control-of-the-function-of-the-striatopallidal-neuron-by-pre-coupled-complexes-of-adenosine-a-2a-dopamine-d-2-receptor-heterotetramers-and-adenylyl-cyclase
#19
Sergi Ferré, Jordi Bonaventura, Wendy Zhu, Candice Hatcher-Solis, Jaume Taura, César Quiroz, Ning-Sheng Cai, Estefanía Moreno, Verónica Casadó-Anguera, Alexxai V Kravitz, Kimberly R Thompson, Dardo G Tomasi, Gemma Navarro, Arnau Cordomí, Leonardo Pardo, Carme Lluís, Carmen W Dessauer, Nora D Volkow, Vicent Casadó, Francisco Ciruela, Diomedes E Logothetis, Daniel Zwilling
The central adenosine system and adenosine receptors play a fundamental role in the modulation of dopaminergic neurotransmission. This is mostly achieved by the strategic co-localization of different adenosine and dopamine receptor subtypes in the two populations of striatal efferent neurons, striatonigral and striatopallidal, that give rise to the direct and indirect striatal efferent pathways, respectively. With optogenetic techniques it has been possible to dissect a differential role of the direct and indirect pathways in mediating "Go" responses upon exposure to reward-related stimuli and "NoGo" responses upon exposure to non-rewarded or aversive-related stimuli, respectively, which depends on their different connecting output structures and their differential expression of dopamine and adenosine receptor subtypes...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29686471/analysis-of-aggressiveness-factors-in-hepatocellular-carcinoma-patients-undergoing-transarterial-chemoembolization
#20
Yossi Ventura, Brian I Carr, Issac Kori, Vito Guerra, Oren Shibolet
AIM: To investigate novel predictors of survival in hepatocellular carcinoma (HCC) patients following transarterial chemoembolization (TACE). METHODS: One hundred sixty seven patients with un-resectable HCC were retrospectively analyzed to identify factors that might contribute to their HCC biology and aggressiveness. We correlated routine laboratory results (total bilirubin, AST, ALKP, GGTP, albumin etc .) to maximum tumor diameter, number of tumor nodules, portal vein thrombosis and blood alpha-fetoprotein levels...
April 21, 2018: World Journal of Gastroenterology: WJG
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