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https://www.readbyqxmd.com/read/28202192/ordered-mesoporous-silica-functionalized-with-%C3%AE-cyclodextrin-derivative-for-stereoisomer-separation-of-flavanones-and-flavanone-glycosides-by-nano-liquid-chromatography-and-capillary-electrochromatography
#1
Mariana Silva, Damián Pérez-Quintanilla, Sonia Morante-Zarcero, Isabel Sierra, María Luisa Marina, Zeineb Aturki, Salvatore Fanali
In this paper a chiral stationary phase (CSP) was prepared by the immobilization of a β-CD derivative (3,5-dimethylphenylcarbamoylated β-CD) onto the surface of amino-functionalized spherical ordered mesoporous silica (denoted as SM) via a urea linkage using the Staudinger reaction. The CSP was packed into fused silica capillaries 100μm I.D. and evaluated by means of nano-liquid chromatography (nano-LC) and capillary electrochromatography (CEC) using model compounds for the enantio- and the diastereomeric separation...
February 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28192136/inhibition-of-glycation-and-aldose-reductase-activity-using-dietary-flavonoids-a-lens-organ-culture-studies
#2
Kapil K Patil, Rajesh N Gacche
On the eve of increasing incidence of diabetes mellitus and related complications, the search for novel, safe and alternatives therapeutic approaches are evolving. In the present investigation, a panel of ten dietary flavonoids such as 4'-methoxyflavanone, formononetin, hesperetin, hesperidin, naringenin, naringin, rutin, diadzin, silibinin and silymarin was evaluated as possible inhibitors of sugar induced cataractogenesis using bovine lens organ culture studies. The effect of selected flavonoids was observed on glycation induced lens opacity, AGE fluorescence, carbonyl group formation (a biomarker of glycation), protein aggregation and aldose reductase (AR) inhibition...
February 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28174089/controllable-immobilization-of-naringinase-on-electrospun-cellulose-acetate-nanofibers-and-their-application-to-juice-debittering
#3
Weijuan Huang, Yingfei Zhan, Xiaowen Shi, Jiajia Chen, Hongbing Deng, Yumin Du
Electrospinning is a facile method to fabricate nanofibers, in terms of their high specific surface area and porous structure. Electrospun nanofibrous mats are excellent candidates for immobilization of enzymes. In this study, a simple route based on electrospinning and layer-by-layer (LBL) self-assembly processes has been developed to prepared naringinase/alginate multilayer coated electrospun cellulose acetate nanofibers. The content of immobilized naringinase could be tuned by adjusting the number of multilayers...
February 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28165379/in-vitro-lipophilic-antioxidant-capacity-antidiabetic-and-antibacterial-activity-of-citrus-fruits-extracts-from-aceh-indonesia
#4
Ernawita, Ruri Agung Wahyuono, Jana Hesse, Uta-Christina Hipler, Peter Elsner, Volker Böhm
This study reports in vitro lipophilic antioxidant, inhibition of α-amylase and antibacterial activities of extracts of peel and pulp of citrus samples from Aceh, Indonesia. HPLC (high-performance liquid chromatography), phytochemical, and FTIR (fourier transform infrared) analysis detected carotenoids, flavonoids, phenolic acids and terpenoids, contributing to the biological potencies. Most peel and pulp extracts contained lutein and lower concentrations of zeaxanthin, α-carotene, β-carotene and β-cryptoxanthin...
February 3, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28159252/a-process-to-preserve-valuable-compounds-and-acquire-essential-oils-from-pomelo-flavedo-using-a-microwave-irradiation-treatment
#5
Zaizhi Liu, Yuangang Zu, Lei Yang
A microwave pretreatment method was developed to preserve pectin, naringin, and limonin contents in pomelo flavedo to allow for longer storage times and subsequent extraction of pomelo essential oil. In terms of the essential oil, microwave pretreatment performed better than hydrodistillation with respect to extraction efficiency (1.88±0.06% in 24min versus 1.91±0.08% in 240min), oxygenation fraction (48.59±1.32% versus 29.63±1.02%), energy consumption (0.15kWh versus 1.54kWh), and environmental impact (123...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28119357/stimulus-dependent-effects-of-temperature-on-bitter-taste-in-humans
#6
Barry G Green, Kendra Andrew
This study investigated the effects of temperature on bitter taste in humans. The experiments were conducted within the context of current understanding of the neurobiology of bitter taste and recent evidence of stimulus-dependent effects of temperature on sweet taste. In the first experiment, the bitterness of caffeine and quinine sampled with the tongue tip was assessed at 4 different temperatures (10°, 21°, 30°, and 37 °C) following pre-exposure to the same solution or to water for 0, 3, or 10 s. The results showed that initial bitterness (0-s pre-exposure) followed an inverted U-shaped function of temperature for both stimuli, but the differences across temperature were statistically significant only for quinine...
February 2017: Chemical Senses
https://www.readbyqxmd.com/read/28110962/%C3%AE-l-rhamnosidase-selective-for-rutin-to-isoquercitrin-transformation-from-penicillium-griseoroseum-mtcc-9224
#7
Sarita Yadav, Sudha Yadava, Kapil D S Yadav
An α-l-rhamnosidase secreting fungal strain has been isolated from the decaying goose berry (Emblica officinalis) fruit peel. The fungal strain has been identified as Penicillium greoroseum MTCC-9224. The α-l-rhamnosidase of this fungal strain has been purified to homogeneity using a simple procedure involving concentration by ultra filtration and an anion exchange chromatography on DEAE-cellulose. The purified enzyme gave a single protein band corresponding to molecular mass of 97kDa in SDS-PAGE analysis...
January 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28110667/identification-of-a-novel-penicillium-chrysogenum-rhamnogalacturonan-rhamnohydrolase-and-the-first-report-of-a-rhamnogalacturonan-rhamnohydrolase-gene
#8
Shotaro Matsumoto, Hiroyuki Yamada, Yuika Kunishige, Shigeo Takenaka, Masami Nakazawa, Mitsuhiro Ueda, Tatsuji Sakamoto
Rhamnogalacturonan (RG) I is one of the main components of pectins in the plant cell wall. We recently reported two RG I-degrading enzymes, endo-RG and exo-RG lyases, secreted by Penicillium chrysogenum 31B. Here, our aims were to purify a RG rhamnohydrolase (PcRGRH78A) from the culture filtrate of this strain and to characterize this enzyme. On the basis of the internal amino acid sequences, the encoding gene, Pcrgrh78A, was cloned and overexpressed in Aspergillus oryzae. The deduced amino acid sequence of PcRGRH78A is highly similar to an uncharacterized protein belonging to glycoside hydrolase family 78...
March 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28101344/evaluation-of-pharmacological-relaxation-effect-of-the-natural-product-naringin-on-in-vitro-cultured-airway-smooth-muscle-cells-and-in-vivo-ovalbumin-induced-asthma-balb-c-mice
#9
Yue Wang, Yun Lu, Mingzhi Luo, Xiaohao Shi, Yan Pan, Huilong Zeng, Linhong Deng
Asthma has become a common chronic respiratory disease worldwide and its prevalence is predicted to continue increasing in the next decade, particularly in developing countries. A key component in asthma therapy is to alleviate the excessive bronchial airway narrowing ultimately due to airway smooth muscle contraction, which is often facilitated by a smooth muscle relaxant, such as the β2-adrenergic agonists. Recently, bitter taste receptor (TAS2R) agonists, including saccharin and chloroquine, have been found to potently relax the airway smooth muscle cells (ASMCs) via intracellular Ca(2+) signaling...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28063211/nmr-metabolomics-investigates-the-influence-of-flavonoid-enriched-rations-on-chicken-plasma
#10
Charalambos Fotakis, Dimitra Z Lantzouraki, Michael Goliomytis, Panagiotis E Simitzis, Maria Charismiadou, Stelios G Deligeorgis, Panagiotis Zoumpoulakis
The use of flavonoids as dietary supplements is well established, mainly due to their intense antioxidant and anti-inflammatory properties. In the present study, hesperidin, naringin, and vitamin E were used as additives at different concentrations in poultry rations in order to achieve meat of improved quality. NMR metabolomics was applied to chicken blood serum samples to discern whether and how the enriched rations affected the animals’ metabolic profile. Variations in the metabolic patterns according to sustenance consumption were traced by orthogonal projections to latent structures discriminant analysis (OPLS-DA) models and were attributed to specific metabolites by using S-line plots...
January 7, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28032362/prioritizing-pharmacokinetic-drug-interaction-precipitants-in-natural-products-application-to-oatp-inhibitors-in-grapefruit-juice
#11
Emily J Johnson, Christina S Won, Kathleen Köeck, Mary F Paine
Natural products, including botanical dietary supplements and exotic drinks, represent an ever-increasing share of the health care market. The parallel ever-increasing popularity of self-medicating with natural products increases the likelihood of co-consumption with conventional drugs, raising concerns for unwanted natural product-drug interactions. Assessing the drug interaction liability of natural products is challenging due to the complex and variable chemical composition inherent to these products, necessitating a streamlined preclinical testing approach to prioritize precipitant individual constituents for further investigation...
December 29, 2016: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28025998/in-vitro-screening-of-radioprotective-properties-in-the-novel-glucosylated-flavonoids
#12
Hao Yu, Jeremy S Haskins, Cathy Su, Allison Allum, Alexis H Haskins, Victoria A Salinas, Shigeaki Sunada, Taisuke Inoue, Yasushi Aizawa, Mitsuru Uesaka, Takamitsu A Kato
Novel glucosyl flavonoids are developed by the addition of glucose to naturally occurring flavonoids. Flavonoids are known antioxidants that possess radioprotective properties. In order to investigate the radioprotective properties of novel glucosyl flavonoids, in vitro DNA double-strand breaks (DSBs) analysis was carried out. In the present study, Quercetin, Naringenin, and Hesperetin groups of flavonoids included in the natural and novel glucosyl 13 flavonoids were investigated. Flavonoids were mixed with Lambda DNA, and subsequently exposed to gamma‑rays...
November 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28025523/development-of-a-uplc-tq-ms-approach-for-the-determination-of-eleven-bioactive-components-in-haizao-yuhu-decoction-plus-minus-haizao-and-gancao-drug-combination-after-oral-administration-in-a-rat-model-of-hypothyroidism
#13
Yingchang Ma, Yang Zhang, Yuanjuan Zhai, Zhenhua Zhu, Ying Pan, Dawei Qian, Shulan Su, Xinsheng Fan, Jinao Duan
Haizao Yuhu Decoction (HYD) has been used for approximately 500 years and is well-known in Traditional Chinese Medicine for its efficacy in the treatment of thyroid-related diseases. In this study, a rapid liquid chromatography-tandem mass spectrometry method was developed for the determination of liquiritin, naringin, hesperidin, peimine, liquiritigenin, glycyrrhizic acid, bergapten, nobiletin, osthole, and glycyrrhetinic acid in rat plasma to investigate the pharmacokinetic profile of different HYD prescriptions in a rat model of hypothyroidism...
December 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28011192/naringin-alleviates-early-brain-injury-after-experimental-subarachnoid-hemorrhage-by-reducing-oxidative-stress-and-inhibiting-apoptosis
#14
Yuwei Han, Jingyuan Su, Xiujuan Liu, Yuan Zhao, Chenchen Wang, Xiaoming Li
This study aims to clarify the neuroprotective effect of naringin on early brain injury (EBI) following subarachnoid hemorrhage (SAH) and the possible mechanisms of naringin in the treatment of SAH. The endovascular puncture model was performed to induce SAH model in rats and the efficacy of 40mg/kg and 80mg/kg naringin were tested by intraperitoneally administration. SAH grade, neurological score, brain edema, blood-brain barrier permeability, the changes of oxidative stress related factors, apoptosis-related proteins, mitogen-activated protein kinase (MAPK) signaling pathway and neuronal morphology were detected to analyze the potential effect of naringin against SAH...
December 21, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27988309/naringenin-suppresses-edwardsiella-tarda-infection-in-gaks-cells-by-nana-sialidase-inhibition
#15
Sayaka Shinyoshi, Yuko Kamada, Koki Matsusaki, Petros Kingstone Chigwechokha, Supawan Tepparin, Kyosuke Araki, Masaharu Komatsu, Kazuhiro Shiozaki
Edwardsiella tarda (E. tarda) is a gram-negative bacterium, which causes Edwardsiellosis in aquaculture. Previous studies indicate that E. tarda NanA sialidase plays crucial roles in infection through the desialylation of glycoproteins in fish cells. On the other hand, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid, classic sialidase inhibitor, negatively regulates E. tarda infection of goldfish scale GAKS cells. Here, to development the suppression model of E. tarda infection for aquaculture application, the possibility of NanA inhibitory activities in citrus phytochemicals was evaluated as citrus extracts have widely been used as a supplement in fish diets for the improvement of meat quality...
February 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27941619/black-crowberry-empetrum-nigrum-l-flavonoids-and-their-health-promoting-activity
#16
REVIEW
Tunde Jurikova, Jiri Mlcek, Sona Skrovankova, Stefan Balla, Jiri Sochor, Mojmir Baron, Daniela Sumczynski
Nowadays, much research attention is focused on underutilized berry crops due to the high antioxidant activity of fruits. Black crowberry (Empetrum nigrum L.) represents an important source of flavonols (quercetin, rutin, myricetin, naringenin, naringin, morin, and kaempferol) and anthocyanins. The fruit components could be utilised as natural colourants or as a part of functional foods and, because of the high antioxidant activity, the berries of black crowberry can be used in the treatment of diseases accompanied with inflammation, or as an effective antibacterial and antifungal remedy...
December 7, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27937032/effects-of-naringin-on-physical-fatigue-and-serum-mmp-9-concentration-in-female-rats
#17
Mohammad Zamanian, Mohammadreza Hajizadeh, Ali Shamsizadeh, Mohammad Moemenzadeh, Morteza Amirteimouri, Mohammad Elshiekh, Mohammad Allahtavakoli
CONTEXT: Oxidative stress has a critical role in the development of physical fatigue and activation of matrix metalloproteinases-9 (MMP-9). Naringin (Nar) is a bioflavonoid that has antioxidant activity and suppresses MMP-9 expression. OBJECTIVE: The present study evaluates the anti-fatigue activity of Nar on physical fatigue and serum MMP-9 concentration in rats. MATERIALS AND METHODS: Fifty female Wistar rats were randomly divided into five groups (n = 10); a control group, vehicle group and three Nar treatment groups...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27935131/evaluation-of-interactions-between-raw264-7-macrophages-and-small-molecules-by-capillary-electrophoresis
#18
Feng-Qin Wang, Qiao-Qiao Li, Qian Zhang, Yin-Zhen Wang, Yuan-Jia Hu, Peng Li, Jian-Bo Wan, Feng-Qing Yang, Zhi-Ning Xia
In this study, the affinity interactions between RAW 264.7 macrophages and three small molecules including naringin, oleuropein and paeoniflorin were evaluated by affinity capillary electrophoresis (ACE), partial filling affinity capillary electrophoresis (PFACE) and frontal analysis capillary electrophoresis (FACE), respectively. The result indicated that ACE (varying concentrations of cell suspension were filled in the capillary as receptor) may not be suitable for the evaluation of interactions between cell and small molecules due to the high viscosity of cell suspension; PFACE can qualitatively evaluate the interaction, but the difference in viscosity between RAW264...
December 9, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27904711/naringin-promotes-osteogenic-differentiation-of-bone-marrow-stromal-cells-by-up-regulating-foxc2-expression-via-the-ihh-signaling-pathway
#19
Fei-Xiang Lin, Shi-Xin Du, De-Zhong Liu, Qin-Xiao Hu, Guo-Yong Yu, Chu-Cheng Wu, Gui-Zhou Zheng, Da Xie, Xue-Dong Li, Bo Chang
Naringin is an active compound extracted from Rhizoma Drynariae, and studies have revealed that naringin can promote proliferation and osteogenic differentiation of bone marrow stromal cells (BMSCs). In this study, we explored whether naringin could promote osteogenic differentiation of BMSCs by upregulating Foxc2 expression via the Indian hedgehog (IHH) signaling pathway. BMSCs were cultured in basal medium, basal medium with naringin, osteogenic induction medium, osteogenic induction medium with naringin and osteogenic induction medium with naringin in the presence of the IHH inhibitor cyclopamine (CPE)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27848901/herb-medicines-against-osteoporosis-active-compounds-relevant-biological-mechanisms
#20
Lei Wu, Zhuoyan Ling, Xueqin Feng, Caiping Mao, Zhice Xu
Osteoporosis is one of common bone disorders, affecting millions of people worldwide. Treatments of osteoporosis consist of pharmacotherapy and non-pharmacological interventions, such as mineral supplementation, lifestyle changes, and exercise programs. Due to the minimum side effects and favorable cost-effective therapeutic effects, herbal medicine has been widely applied in clinical practices for more than 2,000 years in China. Of the many traditional formulas reported for treating bone diseases, 4 single herbs namely (1) Herba Epimedii, (2) Rhizoma Drynariae, (3) Fructus Psoraleae, and (4) Cortex Eucommiae, are considered as the featured "Kidney-Yang" tonics, and frequently and effectively applied for preventing and treating osteoporosis...
November 16, 2016: Current Topics in Medicinal Chemistry
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