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Naringin

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https://www.readbyqxmd.com/read/28548484/controlled-release-of-naringin-in-metal-organic-frameworks-mofs-loaded-mineralized-collagen-coating-to-simultaneously-enhance-osseointegration-and-antibacterial-activity
#1
Mengfei Yu, Dongqi You, Junjun Zhuang, Suya Lin, Lingqing Dong, Shengtao Weng, Bin Zhang, Kui Cheng, Wen-Jian Weng, Huiming Wang
Two important goals in orthopedic implants research are to promote osseointegration and prevent infection. However, much of previous efforts have been paid on the design of coatings either to enhance osseointegration while ignoring antibacterial activity or vice versa, to prevent infection while ignoring bone integration. Here, we designed a multifunctional mineralized collagen coating on titanium with the aid of metal-organic frameworks (MOFs) nanocrystals to control the release of naringin, a Chinese herbal medicine which could promote osseointegration and prevent bacterial infection...
May 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28541668/matrix-effects-and-interferences-of-different-citrus-fruits-co-extractives-in-pesticide-residue-analysis-using-ultra-high-performance-liquid-chromatography-high-resolution-mass-spectrometry
#2
Natalia Besil, Veronica Cesio, Horacio Heinzen, Amadeo R Fernández-Alba
The matrix effects of ethyl acetate extracts from seven different citrus fruits on the determination of 80 pesticide residues using liquid chromatography coupled to high resolution time of flight mass spectrometry (UHPLC-(ESI)-HR-TOF) at 4 GHz resolution mode were studied. Only 20% of the evaluated pesticides showed noticeable matrix effects (ME) due to co-elution with natural products between tR=3-11 minutes. Principal components analysis (PCA) of the co-extractives detected grouped the mandarins and the orange varieties, but separated lemon, oranges, and mandarins from each other...
May 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28513167/quercetin-luteolin-phloretin-and-morin-are-dietary-flavonoid-inhibitors-of-monocarboxylate-transporter-6
#3
Robert Spencer Jones, Mark Parker, Marilyn Emily Morris
Monocarboxylate transporter 6 (MCT6; SLC16A5) has been recognized for its role as a xenobiotic transporter, with characterized substrates probenecid, bumetanide, and nateglinide. To date, the impact of commonly ingested dietary compounds on MCT6 function has not been investigated and therefore, the objective of this study was to evaluate a variety of flavonoids for their potential MCT6-specific interactions. Flavonoids are a large group of polyphenolic phytochemicals found in commonly consumed plant-based products that have been recognized for their dietary health benefits...
May 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28500940/efficient-catalytic-hydration-of-cyanamides-in-aqueous-medium-and-in-the-presence-of-naringin-sulfuric-acid-or-green-synthesized-silver-nanoparticles-by-using-gongronema-latifolium-leaf-extract
#4
Zahra Issaabadi, Mahmoud Nasrollahzadeh, S Mohammad Sajadi
In this paper, a novel, efficient and green method for the preparation of Naringin sulfuric acid (NSA) as a Brønsted acid organocatalyst and silver nanoparticles (Ag NPs) by using Gongronema latifolium leaf extract as a reducing and stabilizing agent is introduced. The catalysts were characterized using the powder XRD, SEM, EDS, TEM, UV-Vis and FT-IR spectroscopy. Afterward, the catalytic activity of synthesized NSA and Ag NPs were investigated for the synthesis of N-monosubstituted ureas via the hydration of cyanamides in aqueous medium...
May 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28479197/anti-atherosclerotic-activities-of-flavonoids-from-the-flowers-of-helichrysum-arenarium-l-moench-through-the-pathway-of-anti-inflammation
#5
Zhonghua Mao, Chunli Gan, Jiuxin Zhu, Nan Ma, Lijun Wu, Libo Wang, Xiaobo Wang
We have successfully established AS model using thoracic aortas vascular ring which evaluated by the morphological changes of blood vessels, the proliferation of VSMC, and the expression of inflammation factors VEGF, CRP, JNK2 and p38. This AS model has the advantages of low cost, convenient and short period of established time. Moreover, we investigated the anti-AS activities of 7 flavonoids Narirutin (1), Naringin (2), Eriodictyol (3), Luteolin (4), Galuteolin (5), Astragalin (6), Kaempferol (7) from flowers of Helichrysum arenarium L...
June 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28469664/the-mechanism-of-naringin-enhanced-remyelination-after-spinal-cord-injury
#6
Wei Rong, Yong-Wei Pan, Xu Cai, Fei Song, Zhe Zhao, Song-Hua Xiao, Cheng Zhang
Our previous study revealed that intragastric administration of naringin improved remyelination in rats with spinal cord injury and promoted the recovery of neurological function of the injured spinal cord. This study sought to reveal the mechanisms by which naringin improves oligodendrocyte precursor cell differentiation and maturation, and promotes remyelination. Spinal cord injury was induced in rats by the weight-drop method. Naringin was intragastrically administered daily (20, 40 mg/kg) for 4 weeks after spinal cord injury induction...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28462109/simultaneous-determination-of-nine-bioactive-compounds-in-yijin-tang-via-high-performance-liquid-chromatography-and-liquid-chromatography-electrospray-ionization-mass-spectrometry
#7
Hye Jin Yang, Nam-Hui Yim, Kwang Jin Lee, Min Jung Gu, Bohyoung Lee, Youn-Hwan Hwang, Jin Yeul Ma
BACKGROUND: Yijin-tang (YJ) has been used traditionally for the treatment of cardiovascular conditions, nausea, vomiting, gastroduodenal ulcers, and chronic gastritis. In this study, a simple and sensitive high-performance liquid chromatography (HPLC) method was developed for the quantitation of nine bioactive compounds in YJ: homogentisic acid, liquiritin, naringin, hesperidin, neohesperidin, liquiritigenin, glycyrrhizin, 6-gingerol, and pachymic acid. METHODS: Chromatographic separation of the analytes was achieved on an RS Tech C18 column (4...
June 2016: Integr Med Res
https://www.readbyqxmd.com/read/28431473/structures-and-bioactivities-of-seven-flavonoids-from-osmanthus-fragrans-jinqiu-essential-oil-extraction-residues
#8
Jiang-Lian Zhou, Xian-Ying Fang, Jing-Qiu Wang, Lin-Guo Zhao, Yi Li, Feng Tang, Yong-De Yue
Osmanthus fragrans are well-known for their fragrance, but it is wasteful if to discard O. fragrans flower after extracting their essential oils. In this paper, we found that O. fragrans flower residues were rich in flavonoids. Six flavonoids and one phenylethanoid glycoside were isolated from the ethanol extract of O. fragrans flower residues, identified as quercetin (1), rutin (2), verbascoside (3), genistin (4), kaempferol (5), isorhamnetin (6) and naringin (7). In bioactivity study, kaempferol (IC50 = 1...
April 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28426254/naringin-protects-viscera-from-ischemia-reperfusion-injury-by-regulating-the-nitric-oxide-level-in-a-rat-model
#9
A Cerkezkayabekir, F Sanal, E Bakar, E Ulucam, M Inan
We investigated the effects of naringin on small intestine, liver, kidney and lung recovery after ischemia/reperfusion (I/R) injury of the gut. Rats were divided randomly into four groups of eight. Group A was the sham control; group B was ischemic for 2 h; group C was ischemic for 2 h and re-perfused for 2 h (I/R); group D was treated with 50 mg/kg naringin after ischemia, then re-perfused for 2 h. Endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) expressions were detected by immunolabeling...
April 20, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28422390/naringin-abates-adverse-effects-of-cadmium-mediated-hepatotoxicity-an-experimental-study-using-hepg2-cells
#10
Visesh Kumar Rathi, Shubhankar Das, Archana Parampalli Raghavendra, Bola Sadashiva Satish Rao
This study investigated the protective potential of Naringin (NIN) against cadmium chloride (CdCl2 ) mediated hepatotoxicity using human hepatocellular carcinoma (HepG2) cells. An optimal concentration of NIN (5 μM) was potent enough to confer cytoprotection against CdCl2 (50 μM) as was observed by MTT assay. Preconditioning with NIN maintained redox homeostasis, mitochondrial membrane potential, and reduced apoptosis as marked by decrease in the percentage sub-G0 /G1 and Annexin V-FITC/propidium iodide positive cells (apoptotic)...
April 19, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/28395989/naringin-ameliorates-diabetic-nephropathy-by-inhibiting-nadph-oxidase-4
#11
Junwei Zhang, Suxia Yang, Huicong Li, Fang Chen, Jun Shi
Naringin, a naturally flavanone glycoside, has been previously demonstrated to alleviate diabetic kidney disease by inhibiting oxidative stress and inflammatory reaction. However, the underlying mechanism of naringin in diabetic nephropathy (DN) has not been fully elucidated. Here, the beneficial effect of naringin on DN in streptozotocin (STZ)-induced DN rats and high glucose (HG)-induced podocytes and its underlying mechanism were elaborated. The result revealed that naringin alleviated STZ-induced renal dysfunction and injury in DN rats, relieved STZ-induced oxidative stress in vivo and inhibited HG-induced apoptosis and reactive oxygen species level i20n vitro...
June 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28330084/covalent-immobilization-of-microbial-naringinase-using-novel-thermally-stable-biopolymer-for-hydrolysis-of-naringin
#12
Ghada E A Awad, Abeer A Abd El Aty, Abeer N Shehata, Mohamed E Hassan, Magdy M Elnashar
Naringinase induced from the fermented broth of marine-derived fungus Aspergillus niger was immobilized into grafted gel beads, to obtain biocatalytically active beads. The support for enzyme immobilization was characterized by ART-FTIR and TGA techniques. TGA revealed a significant improvement in the grafted gel's thermal stability from 200 to 300 °C. Optimization of the enzyme loading capacity increased gradually by 28-fold from 32 U/g gel to 899 U/g gel beads, retaining 99 % of the enzyme immobilization efficiency and 88 % of the immobilization yield...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28322845/metformin-like-antidiabetic-cardio-protective-and-non-glycemic-effects-of-naringenin-molecular-and-pharmacological-insights
#13
REVIEW
Ntsoaki Annah Nyane, Thabiso Bethwel Tlaila, Tanki Gabriel Malefane, Dudu Edith Ndwandwe, Peter Mark Oroma Owira
Metformin is a widely used drug for the treatment of type 2 diabetes (T2D). Its blood glucose-lowering effects are initially due to inhibition of hepatic glucose production and increased peripheral glucose utilization. Metformin has also been shown to have several beneficial effects on cardiovascular risk factors and it is the only oral antihyperglycaemic agent thus far associated with decreased macrovascular complications in patients with diabetes. Adenosine Monophosphate Activated-Protein Kinase (AMPK) is a major cellular regulator of lipid and glucose metabolism...
May 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28293083/pharmacokinetics-and-pharmacodynamics-of-da-cheng-qi-decoction-in-the-liver-of-rats-with-severe-acute-pancreatitis
#14
Yu-Mei Zhang, Hong-Yu Ren, Xian-Lin Zhao, Juan Li, Jun-Yi Li, Fu-Sheng Wu, Hang Su, Wen-Fu Tang
AIM: To explore the pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction (DCQD) in the liver of rats with severe acute pancreatitis (SAP) based on an herbal recipe tissue pharmacology hypothesis. METHODS: Healthy male Sprague-Dawley rats were randomly divided into a sham operation group (SOG); a model group (MG); and low-, median- and high-dose treatment groups (LDG, MDG, and HDG, respectively). Different dosages (6, 12 and 24 g/kg for the LDG, MDG, and HDG, respectively) of DCQD were administered to the rats with SAP...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28282882/maternal%C3%A2-consumption%C3%A2-of%C3%A2-hesperidin%C3%A2-and%C3%A2-naringin%C3%A2-flavanones%C3%A2-exerts%C3%A2-transient%C3%A2-effects%C3%A2-to%C3%A2-tibia%C3%A2-bone%C3%A2-structure%C3%A2-in%C3%A2-female%C3%A2-cd-1%C3%A2-offspring
#15
Sandra M Sacco, Caitlin Saint, Paul J LeBlanc, Wendy E Ward
Hesperidin (HSP) and naringin (NAR), flavanones rich in citrus fruits, support skeletal integrity in adult and aging rodent models. This study determined whether maternal consumption of HSP and NAR favorably programs bone development, resulting in higher bone mineral density (BMD) and greater structure and biomechanical strength (i.e., peak load) in female offspring. Female CD-1 mice were fed a control diet or a HSP + NAR diet five weeks before pregnancy and throughout pregnancy and lactation. At weaning, female offspring were fed a control diet until six months of age...
March 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28270768/extracts-of-immature-orange-aurantii-fructus-immaturus-and-citrus-unshiu-peel-citri-unshiu-pericarpium-induce-p-glycoprotein-and-cytochrome-p450-3a4-expression-via-upregulation-of-pregnane-x-receptor
#16
Naoto Okada, Aki Murakami, Shiori Urushizaki, Misa Matsuda, Kazuyoshi Kawazoe, Keisuke Ishizawa
P-glycoprotein (P-gp) and cytochrome P450 3A4 (CYP3A4) are expressed in the intestine and are associated with drug absorption and metabolism. Pregnane X receptor (PXR) is the key molecule that regulates the expression of P-gp and CYP3A4. Given that PXR activity is regulated by a variety of compounds, it is possible that unknown PXR activators exist among known medicines. Kampo is a Japanese traditional medicine composed of various natural compounds. In particular, immature orange [Aurantii fructus immaturus (IO)] and citrus unshiu peel [Citri unshiu pericarpium (CP)] are common ingredients of kampo...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28263808/structural-characterization-and-bioavailability-of-ternary-nanoparticles-consisting-of-amylose-%C3%AE-linoleic-acid-and-%C3%AE-lactoglobulin-complexed-with-naringin
#17
Tao Feng, Ke Wang, Fangfang Liu, Ran Ye, Xiao Zhu, Haining Zhuang, Zhimin Xu
Naringin is a bioflavonoid that is rich in citrus plants and possesses enormous health benefits. However, the use of naringin as a nutraceutical is significantly limited by its low bioavailability. In this study, a novel water-soluble ternary nanoparticle material consisting of amylose, α-linoleic acid and β-lactoglobulin was developed to encapsulate naringin to improve its bioavailability. The physicochemical characteristics of the ternary nanoparticle-naringin inclusion complex were analysed by ultraviolet-visible spectroscopy (UV), Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), high-resolution transmission electron microscopy (TEM), X-ray diffractometry (XRD) and particle size distribution...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28260042/protective-effect-of-naringin-against-the-lps-induced-apoptosis-of-pc12-cells-implications-for-the-treatment-of-neurodegenerative-disorders
#18
Hui Wang, You Song Xu, Miao Lin Wang, Chao Cheng, Rui Bian, Hao Yuan, Yi Wang, Ting Guo, Lin Lin Zhu, Hang Zhou
Several studies have demonstrated that increased apoptosis plays an essential role in neurodegenerative disorders. It has been demonstrated that lipopolysaccharide (LPS) induces apoptosis largely through the production of intracellular reactive oxygen species (ROS) and inflammatory mediators. In this study, we investigated the potential protective mechanisms of naringin (Nar), a pummelo peel extract, on LPS-induced PC12 cell apoptosis. Nar pre-conditioning prior to stimulation with LPS for 18 h was a prerequisite for evaluating PC12 cell viability and the protective mechanisms of Nar...
April 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28202192/ordered-mesoporous-silica-functionalized-with-%C3%AE-cyclodextrin-derivative-for-stereoisomer-separation-of-flavanones-and-flavanone-glycosides-by-nano-liquid-chromatography-and-capillary-electrochromatography
#19
Mariana Silva, Damián Pérez-Quintanilla, Sonia Morante-Zarcero, Isabel Sierra, María Luisa Marina, Zeineb Aturki, Salvatore Fanali
In this paper a chiral stationary phase (CSP) was prepared by the immobilization of a β-CD derivative (3,5-dimethylphenylcarbamoylated β-CD) onto the surface of amino-functionalized spherical ordered mesoporous silica (denoted as SM) via a urea linkage using the Staudinger reaction. The CSP was packed into fused silica capillaries 100μm I.D. and evaluated by means of nano-liquid chromatography (nano-LC) and capillary electrochromatography (CEC) using model compounds for the enantio- and the diastereomeric separation...
March 24, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28192136/inhibition-of-glycation-and-aldose-reductase-activity-using-dietary-flavonoids-a-lens-organ-culture-studies
#20
Kapil K Patil, Rajesh N Gacche
On the eve of increasing incidence of diabetes mellitus and related complications, the search for novel, safe and alternatives therapeutic approaches are evolving. In the present investigation, a panel of ten dietary flavonoids such as 4'-methoxyflavanone, formononetin, hesperetin, hesperidin, naringenin, naringin, rutin, diadzin, silibinin and silymarin was evaluated as possible inhibitors of sugar induced cataractogenesis using bovine lens organ culture studies. The effect of selected flavonoids was observed on glycation induced lens opacity, AGE fluorescence, carbonyl group formation (a biomarker of glycation), protein aggregation and aldose reductase (AR) inhibition...
May 2017: International Journal of Biological Macromolecules
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