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Naringin

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https://www.readbyqxmd.com/read/28718686/kinetic-study-on-the-inhibition-of-xanthine-oxidase-by-acylated-derivatives-of-flavonoids-synthesised-enzymatically
#1
Maria Elisa Melo Branco de Araújo, Yollanda Edwirges Moreira Franco, Thiago Grando Alberto, Marcia Cristina Fernandes Messias, Camila Wielewski Leme, Alexandra Christine Helena Frankland Sawaya, Patricia de Oliveira Carvalho
Studies have reported that flavonoids inhibit xanthine oxidase (XO) activity; however, poor solubility and stability in lipophilic media limit their bioavailability and applications. This study evaluated the kinetic parameters of XO inhibition and partition coefficients of flavonoid esters biosynthesised from hesperidin, naringin, and rutin via enzymatic acylation with hexanoic, octanoic, decanoic, lauric, and oleic acids catalysed by Candida antarctica lipase B (CALB). Quantitative determination by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) showed higher conversion yields (%) for naringin and rutin esters using acyl donors with 8C and 10C...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28699201/characterization-of-sugar-and-polyphenolic-diversity-in-floral-nectar-of-different-obla%C3%A4-inska-sour-cherry-clones
#2
Basem Guffa, Nebojša M Nedić, Dragana Č Dabić Zagorac, Tomislav B Tosti, Uroš M Gašić, Maja M Natić, Milica M Fotirić Akšić
'Oblačinska' sour cherry, an autochthonous cultivar, is the most planted cultivar in Serbian orchards. Since fruit trees in temperate zone reward insects by producing nectar which 'quality' affects the efficiency of insect pollination, the aim of this study was analyzing of sugars and polyphenolics in floral nectar of 16 'Oblačinska' sour cherry clones with different yielding potential. The contents of sugars and sugar alcohols were analyzed by ion chromatography, while polyphenolic profile was established using liquid chromatography - mass spectrometry technique (LC/MS)...
July 12, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28686835/various-antioxidant-effects-were-attributed-to-different-components-in-the-dried-blossoms-of-citrus-aurantium-l-var-amara-engl
#3
Chun-Yan Shen, Tian-Xing Wang, Xi-Mei Zhang, Jian-Guo Jiang
Citrus aurantium L. var. amara Engl. (CAVA) was traditionally used as edible and medicinal material in China. Total flavonoids (CAVAF), alkaloids (CAVAA), polysaccharides (CAVAP), coumarins (CAVAC) and neroli (CAVAO) were extracted from CAVA. Hesperidin, naringin and neohesperidin composed 83.94% of CAVAF, and synephrine represented 50.56% of CAVAA. Based on 1,1-diphenyl-2-picrylhydrazyl radical (DPPH•), 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt radical cation (ABTS•+), hydroxyl radical (•OH), ferric-reducing antioxidant power (FRAP) and reducing power assays, the antioxidant activities of five components were comprehensively and comparatively investigated...
July 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28682120/comparison-of-the-effects-of-dietary-supplementation-of-flavonoids-on-laying-hen-performance-egg-quality-and-egg-nutrient-profile
#4
H Iskender, G Yenice, E Dokumacioglu, O Kaynar, A Hayırlı, A Kaya
1. The aim of this experiment was to compare the effects of dietary supplementation of hesperidin, naringin and quercetin on laying hen performance, egg quality and egg yolk lipid and protein profiles. A total of 96 Lohmann White laying hens weighing an average of 1500 g at 28 weeks of age were randomly assigned to a basal diet and the basal diet supplemented (0.5 g/kg) with either hesperidin, naringin or quercetin. Each treatment was replicated in 6 cages in an 8-week experimental period. Data were analysed using one-way ANOVA...
July 6, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28675012/-effect-of-naringin-combined-with-bone-morphogenetic-protein-2-on-the-proliferation-and-differentiation-of-mc3t3-e1-cells
#5
Xu Gaoli, Liu Yi, Wu Lili, Shi Qiutao, Huo Guang, Gu Zhiyuan
OBJECTIVE: This study evaluates the biological effects of naringin (NAR) joint bone morphogenetic protein (BMP)-2 on the proliferation, alkaline phosphatase (ALP) activity, and expression of osteoblastogenic genes, such as Runt-related transcription factor 2 (Runx2), collagen Ⅰ (ColⅠ), ALP, and osteocalcin (OCN) of pre-osteoblasts. METHODS: Three different NAR concentrations (10, 100, and 1 000 μmol·L⁻¹) were applied, alone or combined with BMP-2(50 ng·mL⁻¹), to restore the osteoblastogenesis of pre-osteoblasts (MC3T3-E1 cell line)...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28668949/naringin-reverses-neurobehavioral-and-biochemical-alterations-in-intracerebroventricular-collagenase-induced-intracerebral-hemorrhage-in-rats
#6
Navdeep Singh, Yashika Bansal, Ranjana Bhandari, Lovish Marwaha, Raghunath Singh, Kanwaljit Chopra, Anurag Kuhad
Intracerebral hemorrhage (ICH) contributes to 10-15% of all strokes and is a high risk factor for morbidity and mortality as compared to other subtypes of stroke, that is, cerebral ischemia and subarachnoid hemorrhage. Oxidative stress (OS)-induced neuroinflammation and neuronal cell death contribute towards the hallmarks of ICH. Spared antioxidant levels, increased inflammatory cytokines and free radicals in ICH lead to neuronal death and exaggerate the hallmarks of ICH. Intracerebroventricular (ICV) collagenase (COL-induced neuronal cell damage and cognitive deficits form a widely recognized experimental model for ICH...
July 1, 2017: Pharmacology
https://www.readbyqxmd.com/read/28662177/a-new-approach-for-the-assessment-of-the-toxicity-of-polyphenol-rich-compounds-with-the-use-of-high-content-screening-analysis
#7
Magdalena Boncler, Jacek Golanski, Magdalena Lukasiak, Malgorzata Redzynia, Jaroslaw Dastych, Cezary Watala
The toxicity of in vitro tested compounds is usually evaluated based on AC50 values calculated from dose-response curves. However, there is a large group of compounds for which a standard four-parametric sigmoid curve fitting may be inappropriate for estimating AC50. In the present study, 22 polyphenol-rich compounds were prioritized from the least to the most toxic based on the total area under and over the dose-response curves (AUOC) in relation to baselines. The studied compounds were ranked across three key cell indicators (mitochondrial membrane potential, cell membrane integrity and nuclear size) in a panel of five cell lines (HepG2, Caco-2, A549, HMEC-1, and 3T3), using a high-content screening (HCS) assay...
2017: PloS One
https://www.readbyqxmd.com/read/28635611/modulatory-effects-of-naringin-on-hepatic-key-enzymes-of-carbohydrate-metabolism-in-high-fat-diet-low-dose-streptozotocin-induced-diabetes-in-rats
#8
Leelavinothan Pari, Ramasamy Chandramohan
We evaluated the modulatory effects of naringin on altered hepatic key enzymes of carbohydrate metabolism in high-fat diet/low-dose streptozotocin-induced diabetic rats. Oral treatment of naringin at a doses of 20, 40 and 80 mg/kg body weight to diabetic rats for 30 days resulted in a significant reduction in the levels of plasma glucose, blood glycosylated hemoglobin and increase in the levels of plasma insulin and blood hemoglobin. The altered activities of the hepatic key enzymes of carbohydrate metabolism such as hexokinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase, glycogen phosphorylase and glycogen content of diabetic rats were significantly reverted to near normal levels by the treatment of naringin in a dose-dependent manner...
July 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/28617100/discovery-of-potent-and-selective-acetylcholinesterase-ache-inhibitors-acacetin-7-o-methyl-ether-mannich-base-derivatives-synthesised-from-easy-access-natural-product-naringin
#9
Hao-Ran Liu, Xue Men, Xiao-Hui Gao, Lin-Bo Liu, Hao-Qun Fan, Xin-Hua Xia, Qiu-An Wang
Naringin, as a component universal existing in the peel of some fruits or medicinal plants, was usually selected as the material to synthesise bioactive derivates since it was easy to gain with low cost. In present investigation, eight new acacetin-7-O-methyl ether Mannich base derivatives (1-8) were synthesised from naringin. The bioactivity evaluation revealed that most of them exhibited moderate or potent acetylcholinesterase (AChE) inhibitory activity. Among them, compound 7 (IC50 for AChE = 0.82 ± 0...
June 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28578029/investigation-of-the-interaction-for-three-citrus-flavonoids-and-%C3%AE-amylase-by-surface-plasmon-resonance
#10
Xia Liu, Fang Luo, Pao Li, Yin She, Wanru Gao
Flavonoids, a class of natural drugs with broad biological activity, exhibit inhibitory effect on α-amylase. Citrus peel is a good source of flavonoids. The real-time interactions between three Citrus flavonoids (naringin, neohesperidin, hesperidin) and α-amylase were investigated by surface plasmon resonance biosensor, and were compared with the α-amylase inhibitors, acarbose. These results showed the binding affinities of naringin, neohesperidin and hesperidin with α-amylase reach the highest at pH6 with KD values of 2...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28572940/influence-of-storage-temperature-and-low-temperature-conditioning-on-the-levels-of-health-promoting-compounds-in-rio-red-grapefruit
#11
Priyanka R Chaudhary, Xiang Yu, Guddadarangavvanahally K Jayaprakasha, Bhimanagouda S Patil
Commercial operations use low-temperature conditioning of citrus fruits to reduce the incidence of chilling injury (CI) during cold storage and quarantine treatments. Rio Red grapefruits (Citrus paradisi Macf) were stored for 12 weeks at 11°C or 5°C; an additional set was temperature conditioned at 16°C for 7 days before storing at 5°C (CD). Every 3 weeks, samples were assessed for chilling injury (CI) and health-promoting compounds such as ascorbic acid, carotenoids, limonoids, flavonoids, and furocoumarins...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28554841/erk1-2-signaling-mediated-naringin-induced-osteogenic-differentiation-of-immortalized-human-periodontal-ligament-stem-cells
#12
Kai Wei, Yuansheng Xie, Tianyu Chen, Bo Fu, Shaoyuan Cui, Yan Wang, Guangyan Cai, Xiangmei Chen
Periodontal ligament stem cells (PDLSCs) are promising tools for the investigations of cell differentiation and bone regeneration. However, the limited life span significantly restricts their usefulness. In this study, we established an immortalized PDLSC cell line by the introduction of Bmi1 (PDLSC-Bmi1). Several genes related to cell cycle, cell replication and stemness were found to be changed with the overexpression of Bmi1. Compared with primary PDLSCs, the immortalized cells had a slower aging rate, maintained in a proliferative state without crisis for more than 30 passages, and retained the molecular markers and biological functions of primary ones...
May 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28548484/controlled-release-of-naringin-in-metal-organic-framework-loaded-mineralized-collagen-coating-to-simultaneously-enhance-osseointegration-and-antibacterial-activity
#13
Mengfei Yu, Dongqi You, Junjun Zhuang, Suya Lin, Lingqing Dong, Shengtao Weng, Bin Zhang, Kui Cheng, Wenjian Weng, Huiming Wang
Two important goals in orthopedic implant research are to promote osseointegration and prevent infection. However, much previous effort has been focused on the design of coatings to either enhance osseointegration while ignoring antibacterial activity or vice versa, to prevent infection while ignoring bone integration. Here, we designed a multifunctional mineralized collagen coating on titanium with the aid of metal-organic framework (MOF) nanocrystals to control the release of naringin, a Chinese herbal medicine that could promote osseointegration and prevent bacterial infection...
June 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28541668/matrix-effects-and-interferences-of-different-citrus-fruit-coextractives-in-pesticide-residue-analysis-using-ultrahigh-performance-liquid-chromatography-high-resolution-mass-spectrometry
#14
Natalia Besil, Verónica Cesio, Horacio Heinzen, Amadeo R Fernandez-Alba
The matrix effects of ethyl acetate extracts from seven different citrus fruits on the determination of 80 pesticide residues using liquid chromatography coupled to high-resolution time-of-flight mass spectrometry (UHPLC-(ESI)-HR-TOF) at 4 GHz resolution mode were studied. Only 20% of the evaluated pesticides showed noticeable matrix effects (ME) due to coelution with natural products between tR = 3 and 11 min. Principal component analysis (PCA) of the detected coextractives grouped the mandarins and the orange varieties, but separated lemon, oranges, and mandarins from each other...
June 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28513167/quercetin-morin-luteolin-and-phloretin-are-dietary-flavonoid-inhibitors-of-monocarboxylate-transporter-6
#15
Robert S Jones, Mark D Parker, Marilyn E Morris
Monocarboxylate transporter 6 (MCT6; SLC16A5) has been recognized for its role as a xenobiotic transporter, with characterized substrates probenecid, bumetanide, and nateglinide. To date, the impact of commonly ingested dietary compounds on MCT6 function has not been investigated, and therefore, the objective of this study was to evaluate a variety of flavonoids for their potential MCT6-specific interactions. Flavonoids are a large group of polyphenolic phytochemicals found in commonly consumed plant-based products that have been recognized for their dietary health benefits...
May 31, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28500940/efficient-catalytic-hydration-of-cyanamides-in-aqueous-medium-and-in-the-presence-of-naringin-sulfuric-acid-or-green-synthesized-silver-nanoparticles-by-using-gongronema-latifolium-leaf-extract
#16
Zahra Issaabadi, Mahmoud Nasrollahzadeh, S Mohammad Sajadi
In this paper, a novel, efficient and green method for the preparation of Naringin sulfuric acid (NSA) as a Brønsted acid organocatalyst and silver nanoparticles (Ag NPs) by using Gongronema latifolium leaf extract as a reducing and stabilizing agent is introduced. The catalysts were characterized using the powder XRD, SEM, EDS, TEM, UV-Vis and FT-IR spectroscopy. Afterward, the catalytic activity of synthesized NSA and Ag NPs were investigated for the synthesis of N-monosubstituted ureas via the hydration of cyanamides in aqueous medium...
October 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28479197/anti-atherosclerotic-activities-of-flavonoids-from-the-flowers-of-helichrysum-arenarium-l-moench-through-the-pathway-of-anti-inflammation
#17
Zhonghua Mao, Chunli Gan, Jiuxin Zhu, Nan Ma, Lijun Wu, Libo Wang, Xiaobo Wang
We have successfully established AS model using thoracic aortas vascular ring which evaluated by the morphological changes of blood vessels, the proliferation of VSMC, and the expression of inflammation factors VEGF, CRP, JNK2 and p38. This AS model has the advantages of low cost, convenient and short period of established time. Moreover, we investigated the anti-AS activities of 7 flavonoids Narirutin (1), Naringin (2), Eriodictyol (3), Luteolin (4), Galuteolin (5), Astragalin (6), Kaempferol (7) from flowers of Helichrysum arenarium L...
June 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28469664/the-mechanism-of-naringin-enhanced-remyelination-after-spinal-cord-injury
#18
Wei Rong, Yong-Wei Pan, Xu Cai, Fei Song, Zhe Zhao, Song-Hua Xiao, Cheng Zhang
Our previous study revealed that intragastric administration of naringin improved remyelination in rats with spinal cord injury and promoted the recovery of neurological function of the injured spinal cord. This study sought to reveal the mechanisms by which naringin improves oligodendrocyte precursor cell differentiation and maturation, and promotes remyelination. Spinal cord injury was induced in rats by the weight-drop method. Naringin was intragastrically administered daily (20, 40 mg/kg) for 4 weeks after spinal cord injury induction...
March 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28462109/simultaneous-determination-of-nine-bioactive-compounds-in-yijin-tang-via-high-performance-liquid-chromatography-and-liquid-chromatography-electrospray-ionization-mass-spectrometry
#19
Hye Jin Yang, Nam-Hui Yim, Kwang Jin Lee, Min Jung Gu, Bohyoung Lee, Youn-Hwan Hwang, Jin Yeul Ma
BACKGROUND: Yijin-tang (YJ) has been used traditionally for the treatment of cardiovascular conditions, nausea, vomiting, gastroduodenal ulcers, and chronic gastritis. In this study, a simple and sensitive high-performance liquid chromatography (HPLC) method was developed for the quantitation of nine bioactive compounds in YJ: homogentisic acid, liquiritin, naringin, hesperidin, neohesperidin, liquiritigenin, glycyrrhizin, 6-gingerol, and pachymic acid. METHODS: Chromatographic separation of the analytes was achieved on an RS Tech C18 column (4...
June 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28431473/structures-and-bioactivities-of-seven-flavonoids-from-osmanthus-fragrans-jinqiu-essential-oil-extraction-residues
#20
Jiang-Lian Zhou, Xian-Ying Fang, Jing-Qiu Wang, Lin-Guo Zhao, Yi Li, Feng Tang, Yong-De Yue
Osmanthus fragrans are well-known for their fragrance, but it is wasteful if to discard O. fragrans flower after extracting their essential oils. In this paper, we found that O. fragrans flower residues were rich in flavonoids. Six flavonoids and one phenylethanoid glycoside were isolated from the ethanol extract of O. fragrans flower residues, identified as quercetin (1), rutin (2), verbascoside (3), genistin (4), kaempferol (5), isorhamnetin (6) and naringin (7). In bioactivity study, kaempferol (IC50 = 1...
April 21, 2017: Natural Product Research
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