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https://www.readbyqxmd.com/read/29334407/chiral-separation-of-novel-iminonaringenin-derivatives
#1
Meriem Bouanini, Nasser Belboukhari, J Carlos Menéndez, Khaled Sekkoum, Abdelkarim Cheriti, Hassan Y Aboul-Enein
A series of 4-iminonaringenin derivatives 2-6 have been prepared in good overall yields from a condensation reaction between naringenin and primary amines. The structures of all products were confirmed by ultraviolet, infrared, proton nuclear magnetic resonance, and carbon-13 nuclear magnetic resonance spectroscopic techniques. These derivatives were analyzed by high-performance liquid chromatography using polysaccharide-based chiral stationary phases, namely, Chiralpak IB and Chiralcel OD, using various mobile phases...
January 15, 2018: Chirality
https://www.readbyqxmd.com/read/29314619/naringin-protects-pancreatic-%C3%AE-cells-against-oxidative-stress-induced-apoptosis-by-inhibiting-both-intrinsic-and-extrinsic-pathways-in-insulin-deficient-diabetic-mice
#2
Ye Jin Lim, Jung Ho Kim, Jeong Hoon Pan, Jae Kyeom Kim, Tae-Sik Park, Young Jun Kim, Jin Hyup Lee, Jun Ho Kim
SCOPE: Oxidative stress has been suggested to play a central role in the pathogenesis of diabetes, as well as other metabolic disorders. Naringin, a major flavanone glycoside in citrus species, has been shown to display strong antioxidant potential in in vitro and in vivo models of oxidative stress; however, the underlying protective mechanisms in diabetes are unclear. METHODS AND RESULTS: To study the protective effects and molecular mechanisms of naringin in preventing islet dysfunction and diabetes, we examined glucose homeostasis, β-cell apoptosis, and inflammatory response in insulin-deficient diabetic mice exposed to acute oxidative stress with streptozotocin (STZ)...
January 4, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29287324/development-and-characterization-of-an-%C3%AE-l-rhamnosidase-mutant-with-improved-thermostability-and-a-higher-efficiency-for-debittering-orange-juice
#3
Li Jun Li, Zhe Yu Wu, Yue Yu, Lu Jia Zhang, Yan Bing Zhu, Hui Ni, Feng Chen
The glycoside hydrolase, α-l-rhamnosidase, could remove the bitter taste of naringin from citrus juices. However, most α-l-rhamnosidases are easily deactivated at high temperatures, limiting the practice in debittering citrus juices. The V529A mutant of the α-l-rhamnosidase r-Rha1 from Aspergillus niger JMU-TS528 was developed with improved thermostability using directed evolution technology and site-directed mutagenesis. The enzyme mutant had a half-live of thermal inactivation T(1/2) of 1.92 h, 25.00 min, and 2 min at 60, 65, and 70 °C, respectively...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29279541/in-vitro-evaluation-of-electrospun-plga-plla-pdlla-blend-fibers-loaded-with-naringin-for-guided-bone-regeneration
#4
Zhenzhao Guo, Shuai Wu, Hong Li, Qiyan Li, Gang Wu, Changren Zhou
The present study was to evaluate fiber mesh loaded with naringin via electrospinning to guide bone regeneration in vitro. The naringin-loaded fiber mesh was prepared via elctrospinning of PLGA, PLLA, PDLLA blending solution with naringin. SEM showed that naringin decreased the fiber's diameter according to the concentration of naringin. After 20 days' degradation in PBS, the drugloaded fiber meshes still kept their stability with about 10% decrease in tensile strength. In vitro release experiments showed a sustained and steady naringin releasing profile with little initial burst releasing...
December 27, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/29216513/a-novel-ultradeformable-liposomes-of-naringin-for-anti-inflammatory-therapy
#5
María Pleguezuelos-Villa, Silvia Mir-Palomo, Octavio Díez-Sales, M A Ofelia Vila Buso, Amparo Ruiz Sauri, Amparo Nácher
Ultradeformable liposomes were formulated using naringin (NA), a flavanone glycoside, at different concentrations (3, 6 and 9mg/mL). Nanovesicles were small size (∼100nm), regardless of the NA concentration used, and monodisperse (PI<0.30). All formulations showed a high entrapment efficiency (∼88%) and a highly negative zeta potential (around -30mV). The selected formulations were highly biocompatible as confirmed by in vitro studies using 3T3 fibroblasts. In vitro assay showed that the amounts (%) of NA accumulated in the epidermis (∼10%) could explain the anti-inflammatory properties of ultradeformable liposomes...
December 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29212216/naringin-improves-random-skin-flap-survival-in-rats
#6
Liang Cheng, Tingxiang Chen, Qiming Tu, Hang Li, Zhenghua Feng, Zhijie Li, Dingsheng Lin
Background: Random-pattern flap transfer is commonly used to treat soft-tissue defects. However, flap necrosis remains a serious problem. Naringin accelerates angiogenesis by activating the expression of vascular endothelial growth factor (VEGF). In the present study, we investigated whether naringin improves the survival of random skin flaps. Results: Compared with controls, the naringin-treated groups exhibited significantly larger mean areas of flap survival, significantly increased SOD activity and VEGF expression, and significantly reduced MDA level...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29208404/naringin-prevents-bone-loss-in-a-rat-model-of-type-1-diabetes-mellitus
#7
M Rivoira, V Rodríguez, G Picotto, R Battaglino, N Tolosa de Talamoni
The aim of this work was to know whether naringin (NA) could prevent the bone complications in a model of streptozotocin (STZ) induced diabetes. Rats were divided in: 1) controls, 2) STZ-rats, 3) STZ-rats treated with 40 mg NA/kg, and 4) STZ-rats treated with 80 mg NA/kg. BMD and BMC were performed by DEXA. Bone histomorphometry and histology as well as TRAP staining were done in tibia. Osteocalcin (OCN) was determined in bone and serum. Glutathione content and SOD and catalase activities were assayed in bone marrow from femur...
December 2, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29197498/combination-effect-naringin-and-pravastatin-in-lipid-profile-and-glucose-in-obese-rats
#8
Abdel K Raffoul-Orozco, Ana E Ávila-González, Christian M Rodríguez-Razón, Teresa A García-Cobian, Edsaul E Pérez-Guerrero, Trinidad García-Iglesias, Edy D Rubio Arellano
AIMS: The purpose of this study was to compare the effect of naringin 100mg/kg in combination with pravastatin 10mg/kg by gavage for 6weeks compared with monotherapy over lipid profiles, glucose levels and weight in murine model of obesity. MAIN METHODS: The study design was planned with 5 groups of 6 male Wistar Albina rats: Group 1: control with balanced food and vehicle (C-); Group 2: control with Obesity and vehicle (C+); Group 3: Obesity+naringin (N); Group 4: Obesity+pravastatin (P); Group 5: Obesity+pravastatin+naringin (NP)...
November 29, 2017: Life Sciences
https://www.readbyqxmd.com/read/29184243/starch-digestibility-and-glycemic-index-of-paranthas-supplemented-with-citrus-maxima-burm-merr-fruit-segments
#9
S K Reshmi, M L Sudha, M N Shashirekha
The present investigation was undertaken to develop paranthas suiting diabetic population with added health benefits. Paranthas were prepared using fresh and dry segments of pomelo. The increase in the concentration of segments decreased the texture value from 1080 to 1022 g force (fresh segments) and 1005 to 870 g force (dry segments). Naringin along with other bioactive compounds were retained to a greater extent in Paranthas containing dry pomelo fruit segments. Paranthas prepared using 20% (fresh) and 5% (dry) were sensorily acceptable...
December 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29174446/protective-effect-of-ethyl-acetate-fraction-of-drynaria-quercifolia-against-ccl4-induced-rat-liver-fibrosis-via-nrf2-are-and-nf%C3%AE%C2%BAb-signalling-pathway
#10
G I Anuja, V J Shine, P G Latha, S R Suja
ETHNOPHARMACOLOGICAL RELEVANCE: Drynaria quercifolia rhizome is traditionally used as hepatoprotective drug especially in chronic jaundice. AIM OF THE STUDY: The present study was undertaken to scientifically evaluate the efficacy of D. quercifolia rhizome against liver fibrosis. MATERIALS AND METHODS: D. quercifolia rhizome crude extract (DQ) and its fractions of hexane (HDQ), ethyl acetate (EDQ), butanol (BDQ) were evaluated in vitro using primary hepatocytes and RAW 264...
November 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29163154/biotransformation-of-flavonoid-conjugates-with-fatty-acids-and-evaluations-of-their-functionalities
#11
Cynthia Q Sun, Keryn D Johnson, Herbert Wong, L Y Foo
Enzymatic conjugation with fatty acids including omega-3 polyunsaturated fatty acids (ω-3 PUFAs) derived from fish oil to three citrus fruit-derived flavonoids: grapefruit extract, naringin, and neohesperidin dihydrochalcone were investigated. The conversions were achieved over 85% under the catalysis of lipase Novozyme 435 in acetone at 45°C at semi-preparative scale. The conjugates were purified via solvent partition and silica gel chromatography and achieved 90-98% in purity. The NMR analysis of the conjugates confirmed that the fatty acid carbon chain was linked onto the primary -OH group on the glucose moiety of the flavonoids...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29156531/heated-naringin-mitigate-the-genotoxicity-effect-of-mitomycin-c-in-balb-c-mice-through-enhancing-the-antioxidant-status
#12
Mouna Maatouk, Nadia Mustapha, Imen Mokdad-Bzeouich, Hind Chaaban, Irina Ioannou, Kamel Ghedira, Mohamed Ghoul, Leila Chekir-Ghedira
A major problem with cancer chemotherapy is its severe toxic effects on non-target tissues. Assessment of natural products for their protective effect against anticancer drugs induced toxicity is gaining importance in cancer biology. The aim of the present study was to evaluate the effect of native and thermal treated naringin on the protective effect against mitomycin C (MMC) induced genotoxicity. The genotoxicity in liver kidney and brain cells isolated from Balb/C mice were evaluated by performing the comet assay...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29152646/naringin-protects-myocardial-cells-from-doxorubicin%C3%A2-induced-apoptosis-partially-by-inhibiting-the-p38mapk-pathway
#13
Chun-Yan Jian, Han-Bin Ouyang, Xian-Hong Xiang, Jia-Li Chen, Yong-Xin Li, Xin Zhou, Jin-Yang Wang, Yang Yang, En-Yi Zhong, Wen-Hua Huang, Hong-Wu Zhang
Doxorubicin (DOX) has been widely used to treat cancers as a first‑line antitumor drug. However, it causes severe, irreversible, dose‑dependent cardiotoxicity. To evaluate the protective effects of naringin (NRG) on cardiotoxicity, the authors investigated the molecular mechanism of the p38MAPK signaling pathway. H9c2 cells were treated for 24 h by using 5 µmol/l DOX without or with being pretreated by 1 µM NRG for 150 min or by 3 µM SB203580 for 60 min. Cell viability was detected by cell counting kit‑8 assay...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29151126/nutritional-programming-of-bone-structure-in-male-offspring-by-maternal-consumption-of-citrus-flavanones
#14
Sandra M Sacco, Caitlin Saint, Paul J LeBlanc, Wendy E Ward
Maternal exposure to hesperidin (HSP) and naringin (NAR) during pregnancy and lactation transiently compromised bone mineral density (BMD) and bone structure at the proximal tibia in female CD-1 offspring. We examined whether maternal consumption of HSP + NAR during pregnancy and lactation compromises BMD, bone structure, and bone strength in male CD-1 offspring. Male CD-1 offspring, from mothers fed a control diet (CON, n = 10) or a 0.5% HSP + 0.25% NAR diet (HSP + NAR, n = 8) for 5 weeks before mating and throughout pregnancy and lactation, were weaned and fed CON until 6 months of age...
November 18, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29145756/micronutrients-and-natural-compounds-status-and-their-effects-on-wound-healing-in-the-diabetic-foot-ulcer
#15
Kanokwan Kulprachakarn, Sakaewan Ounjaijean, Jukkrit Wungrath, Raj Mani, Kittipan Rerkasem
The diabetic foot ulcer (DFU) is an invariably common complication of diabetes mellitus, it is also a significant cause of amputation as well as extended hospitalization. As most patients with DFU suffer from malnutrition, which has been related to improper metabolic micronutrients status, alterations can affect impaired wound healing process. Micronutrients and herbal remedies applications present a wide range of health advantages to patients with DFU. The purpose of this review is to provide current evidence on the potential effect of dietary supplementations such as vitamins A, C, D, E, magnesium, zinc, copper, iron, boron, and such naturally occurring compounds as Aloe vera, Naringin, and Radix Astragali (RA) and Radix Rehmanniae (RR) in the administration of lower extremity wounds, especially in DFU, and to present some insights for applications in the treatment of DFU patients in the future...
November 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29145059/binding-of-naringin-and-naringenin-with-hen-egg-white-lysozyme-a-spectroscopic-investigation-and-molecular-docking-study
#16
Sourav Das, Pooja Ghosh, Sudipta Koley, Atanu Singha Roy
The interactions of naringenin (NG) and naringin (NR) with Hen Egg White Lysozyme (HEWL) in aqueous medium have been investigated using UV-vis spectroscopy, steady-state fluorescence, circular dichroism (CD), Fourier Transform infrared spectroscopy (FT-IR) and molecular docking analyses. Both NG and NR can quench the intrinsic fluorescence of HEWL via static quenching mechanism. At 300K, the value of binding constant (Kb) of HEWL-NG complex (5.596±0.063×10(4)M(-1)) was found to be greater than that of HEWL-NR complex (3...
November 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29124335/rhamnosidase-activity-of-selected-probiotics-and-their-ability-to-hydrolyse-flavonoid-rhamnoglucosides
#17
Monika Mueller, Barbara Zartl, Agnes Schleritzko, Margit Stenzl, Helmut Viernstein, Frank M Unger
Bioavailability of flavonoids is low, especially when occurring as rhamnoglucosides. Thus, the hydrolysis of rutin, hesperidin, naringin and a mixture of narcissin and rutin (from Cyrtosperma johnstonii) by 14 selected probiotics was tested. All strains showed rhamnosidase activity as shown using 4-nitrophenyl α-L-rhamnopyranoside as a substrate. Hesperidin was hydrolysed by 8-27% after 4 and up to 80% after 10 days and narcissin to 14-56% after 4 and 25-97% after 10 days. Rutin was hardly hydrolysed with a conversion rate ranging from 0 to 5% after 10 days...
November 10, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29122589/naringin-prevents-the-inhibition-of-intestinal-ca-2-absorption-induced-by-a-fructose-rich-diet
#18
V Rodríguez, M Rivoira, S Guizzardi, N Tolosa de Talamoni
This study tries to elucidate the mechanisms by which fructose rich diets (FRD) inhibit the rat intestinal Ca(2+) absorption, and determine if any or all underlying alterations are prevented by naringin (NAR). Male rats were divided into: 1) controls, 2) treated with FRD, 3) treated with FRD and NAR. The intestinal Ca(2+) absorption and proteins of the transcellular and paracellular Ca(2+) pathways were measured. Oxidative/nitrosative stress and inflammation parameters were evaluated. FRD rats showed inhibition of the intestinal Ca(2+) absorption and decrease in the protein expression of molecules of both Ca(2+) pathways, which were blocked by NAR...
November 7, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29121676/naringin-prevents-hiv-1-protease-inhibitors-induced-metabolic-complications-in-vivo
#19
Sanelisiwe Nzuza, Sindiswa Zondi, Peter M O Owira
BACKGROUND: Insulin resistance, glucose intolerance and overt diabetes are known metabolic complications associated with chronic use of HIV-Protease Inhibitors. Naringin is a grapefruit-derived flavonoid with anti-diabetic, anti-dyslipidemia, anti-inflammatory and anti-oxidant activities. OBJECTIVES: The study investigated the protective effects of naringin on glucose intolerance and impaired insulin secretion and signaling in vivo. METHODS: Male Wistar rats were divided into six groups (n = 6) and were daily orally treated with distilled water {3...
2017: PloS One
https://www.readbyqxmd.com/read/29093618/optimal-timing-for-the-oral-administration-of-da-cheng-qi-decoction-based-on-the-pharmacokinetic-and-pharmacodynamic-targeting-of-the-pancreas-in-rats-with-acute-pancreatitis
#20
Yu-Mei Zhang, Lin Zhu, Xian-Lin Zhao, Huan Chen, Hong-Xin Kang, Jian-Lei Zhao, Mei-Hua Wan, Juan Li, Lv Zhu, Wen-Fu Tang
AIM: To identify the optimal oral dosing time of Da-Cheng-Qi decoction (DCQD) in rats with acute pancreatitis (AP) based on the pharmacokinetic and pharmacodynamic parameters. METHODS: First, 24 male Sprague-Dawley rats were divided into a sham-operated group [NG(a)] and three model groups [4hG(a), 12hG(a) and 24hG(a)]. The NG(a) and model groups were administered DCQD (10 g/kg.BW) intragastrically at 4 h, 4 h, 12 h and 24 h, respectively, after AP models induced by 3% sodium taurocholate...
October 21, 2017: World Journal of Gastroenterology: WJG
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