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https://www.readbyqxmd.com/read/28813782/urea-cycle-pathway-targeted-therapeutic-action-of-naringin-against-ammonium-chloride-induced-hyperammonemic-rats
#1
Arumugam Ramakrishnan, Natesan Vijayakumar
Ammonia is a well-known neurotoxin that causes liver disease and urea cycle disorder. Excessive ammonia content in the blood leads to hyperammonemic condition and affects both excitatory and inhibitory neurotransmission including brain edema and coma. Naringin, a plant bioflavonoid present in various citrus fruits and mainly extracted from the grape fruit. This study was designed to assess the protective effect of naringin on ammonium chloride (NH4Cl) induced hyperammonemic rats. Experimental hyperammonemia was induced by intraperitoneal injections (i...
August 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28810519/the-beneficial-role-of-naringin-a-citrus-bioflavonoid-against-oxidative-stress-induced-neurobehavioral-disorders-and-cognitive-dysfunction-in-rodents-a-systematic-review-and-meta-analysis
#2
REVIEW
Gollapalle Lakshminarayanashastry Viswanatha, H Shylaja, Yogananda Moolemath
OBJECTIVES: Naringin is a bioflavonoid, very abundantly found in citrus species. In literature, naringin has been scientifically well documented for its beneficial effects in various neurological disorders. In this systematic review and meta-analysis, we have made an attempt to correlate the protective role of naringin against oxidative stress-induced neurological disorders in rodents. METHODS: The systematic search was performed using electronic databases; the search was mainly focused on the role of naringin in oxidative stress-induced neuropathological conditions in rodents...
August 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28804610/naringin-enhances-osteogenic-differentiation-through-the-activation-of-erk-signaling-in-human-bone-marrow-mesenchymal-stem-cells
#3
Huichao Wang, Chunbo Li, Jianming Li, Yingjie Zhu, Yudong Jia, Ying Zhang, Xiaodong Zhang, Wenlong Li, Lei Cui, Wuyin Li, Youwen Liu
OBJECTIVES: Naringin has been reported to regulate bone metabolism. However, its effect on osteogenesis remains unclear. The aim was to investigate the effect of naringin on osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through the activation of the ERK signaling pathway in osteogenic differentiation. MATERIALS AND METHODS: Annexin V-FITC assay and MTT assay were used to measure the effect of naringin on cytotoxicity and proliferation of hBMSCs, respectively...
April 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28800907/biochemical-characterization-of-aspergillus-oryzae-recombinant-%C3%AE-l-rhamnosidase-expressed-in-pichia-pastoris
#4
Mai Ishikawa, Yoshihito Shiono, Takuya Koseki
An α-l-rhamnosidase-encoding gene from Aspergillus oryzae, which belongs to the glycoside hydrolase family 78, was cloned and expressed in Pichia pastoris. SDS-PAGE of the purified recombinant α-l-rhamnosidase protein revealed smeared bands with apparent molecular mass of 90-130 kDa. After N-deglycosylation, the recombinant enzyme showed a molecular mass of 70 kDa. The enzyme exhibited optimal activity at a pH of 5.0 and a temperature of 70 °C. Specific activity of the enzyme was higher toward hesperidin than toward naringin, which consist of α-1,6 and α-1,2 linkages, respectively...
August 9, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28765519/effect-of-naringin-on-monosodium-iodoacetate-induced-osteoarthritis-pain-in-rats
#5
Qiang Xu, Zuo-Fu Zhang, Wei-Xue Sun
BACKGROUND The aim of the current study was to evaluate the anti-osteoarthritic and anti-inflammatory effect of naringin in a monosodium iodoacetate (MIA)- induced osteoarthritis (OA) model in rats. The anti-osteoarthritic potential of naringin was evaluated against the MIA-induced OA rat model. MATERIAL AND METHODS Wistar rats were used for the study and were divided into the following groups: normal control (saline-treated); group II (MIA-treated): group III (MIA+Naringin), and group IV (MIA+Indomethacin)...
August 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28764092/starch-digestibility-and-predicted-glycemic-index-in-the-bread-fortified-with-pomelo-citrus-maxima-fruit-segments
#6
S K Reshmi, M L Sudha, M N Shashirekha
The aim of this study was to evaluate the starch digestibility and predicted glycemic index in breads incorporated with pomelo fruit (Citrus maxima) segments. Volume of the white and brown breads supplemented with pomelo fresh segments increased, while the crumb firmness decreased. Bread with 20% fresh and 5% dry pomelo segments were sensorily acceptable. Bioactive components such as phenolics, flavonoids, naringin and carotenoids were retained to a greater extent in bread containing dry pomelo segments. The pomelo incorporated bread had higher levels of resistant starch fractions (3...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28759757/navel-orange-peel-hydroethanolic-extract-naringin-and-naringenin-have-anti-diabetic-potentials-in-type-2-diabetic-rats
#7
Osama M Ahmed, Mohamed A Hassan, Sanaa M Abdel-Twab, Manal N Abdel Azeem
The therapy of Type 2 Diabetes Mellitus (T2DM) stays a challenging issue. During the last decade, there has been an interest in the expansion of anti-diabetic drugs especially those of natural sources. Thus, the aim of this study was to assess the anti-hyperglycemic and the anti-hyperlipidemic effects as well as the anti-oxidant activities of navel orange hydroethanolic extract and its constituting flavonoids naringin and naringenin on nicotineamide (NA)/streptozotocin (STZ)-induced type 2 diabetic rats. To induce T2DM, 16h-fasted rats were intraperitoneally injected with STZ at dose of 50mg/kg body weight (b...
July 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28753918/the-anti-inflammatory-properties-of-citrus-wilsonii-tanaka-extract-in-lps-induced-raw-264-7-and-primary-mouse-bone-marrow-derived-dendritic-cells
#8
Liping Cheng, Yujie Ren, Dingbo Lin, Shu'ang Peng, Bo Zhong, Zhaocheng Ma
'Zhique' (Citrus wilsonii Tanaka) is a traditional Chinese medicine. Its fruits have been used to treat inflammation-related symptoms, such as cough and sputum, though the underlying mechanism remains poorly understood. The aim of this study was to investigate the anti-inflammatory properties of 'Zhique' pulp extract (ZQE) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages and primary mouse bone marrow-derived dendritic cells (BMDCs). The flavonoid profiles of the ZQE were determined by high performance liquid chromatography...
July 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28745128/the-permeability-characteristics-and-interaction-of-main-components-from-si-ni-san-in-a-mdck-epithelial-cell-monolayer-model
#9
Ruonan Chen, Chenlin Shen, Qingqing Xu, Yaru Liu, Bo Li, Cheng Huang, Taotao Ma, Xiaoming Meng, Maomao Wu, Jun Li
1. Si-Ni-San (SNS) possesses extensive therapeutic effects, however, the extent to which main components are absorbed and the mechanisms involved are controversial. 2. In this study, MDCK cell model was used to determine the permeability characteristics and interaction between the major components of Si-Ni-San, including saikosaponin a, paeoniflorin, naringin and glycyrrhizic acid. 3. The transport of the major components was concentration-dependent in both directions. Moreover, the transport of paeoniflorin, naringin and glycyrrhizic acid was significantly reduced at 4°C or in the presence of NaN3...
July 26, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28730621/multiple-homonuclear-band-selective-decoupling-nmr-fast-and-unambiguous-determination-of-diastereomeric-excess
#10
Kavitha Rachineni, Veera Mohana Rao Kakita, Ramakrishna V Hosur
Discrimination and quantification of chiral stereoisomers have been studied by different analytical methods and NMR has emerged as a powerful one with the advancements in pure-shift NMR methods. In the present manuscript, an al-F1F2-MHOBS-DIAG NMR method for the quantification of diastereomeric excess ratio (dr) has been proposed and demonstrated, using Hesperidin and Naringin mixtures. This method enables simultaneous quantification of dr at multiple resonances, in a single experiment, and it takes only ~10 min to record...
July 20, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28718686/kinetic-study-on-the-inhibition-of-xanthine-oxidase-by-acylated-derivatives-of-flavonoids-synthesised-enzymatically
#11
Maria Elisa Melo Branco de Araújo, Yollanda Edwirges Moreira Franco, Thiago Grando Alberto, Marcia Cristina Fernandes Messias, Camila Wielewski Leme, Alexandra Christine Helena Frankland Sawaya, Patricia de Oliveira Carvalho
Studies have reported that flavonoids inhibit xanthine oxidase (XO) activity; however, poor solubility and stability in lipophilic media limit their bioavailability and applications. This study evaluated the kinetic parameters of XO inhibition and partition coefficients of flavonoid esters biosynthesised from hesperidin, naringin, and rutin via enzymatic acylation with hexanoic, octanoic, decanoic, lauric, and oleic acids catalysed by Candida antarctica lipase B (CALB). Quantitative determination by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) showed higher conversion yields (%) for naringin and rutin esters using acyl donors with 8C and 10C...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28699201/characterization-of-sugar-and-polyphenolic-diversity-in-floral-nectar-of-different-obla%C3%A4-inska-sour-cherry-clones
#12
Basem Guffa, Nebojša M Nedić, Dragana Č Dabić Zagorac, Tomislav B Tosti, Uroš M Gašić, Maja M Natić, Milica M Fotirić Akšić
'Oblačinska' sour cherry, an autochthonous cultivar, is the most planted cultivar in Serbian orchards. Since fruit trees in temperate zone reward insects by producing nectar which 'quality' affects the efficiency of insect pollination, the aim of this study was analyzing of sugars and polyphenolics in floral nectar of 16 'Oblačinska' sour cherry clones with different yielding potential. The contents of sugars and sugar alcohols were analyzed by ion chromatography, while polyphenolic profile was established using liquid chromatography - mass spectrometry technique (LC/MS)...
July 12, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28686835/various-antioxidant-effects-were-attributed-to-different-components-in-the-dried-blossoms-of-citrus-aurantium-l-var-amara-engl
#13
Chun-Yan Shen, Tian-Xing Wang, Xi-Mei Zhang, Jian-Guo Jiang
Citrus aurantium L. var. amara Engl. (CAVA) was traditionally used as an edible and medicinal material in China. Total flavonoids (CAVAF), alkaloids (CAVAA), polysaccharides (CAVAP), coumarins (CAVAC), and neroli (CAVAO) were extracted from CAVA. Hesperidin, naringin, and neohesperidin composed 83.94% of CAVAF, and synephrine represented 50.56% of CAVAA. On the basis of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH(•)), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radical cation (ABTS(•) (+)), hydroxyl radical ((•)OH), ferric-reducing antioxidant power (FRAP), and reducing power assays, the antioxidant activities of five components were comprehensively and comparatively investigated...
August 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28682120/comparison-of-the-effects-of-dietary-supplementation-of-flavonoids-on-laying-hen-performance-egg-quality-and-egg-nutrient-profile
#14
H Iskender, G Yenice, E Dokumacioglu, O Kaynar, A Hayırlı, A Kaya
1. The aim of this experiment was to compare the effects of dietary supplementation of hesperidin, naringin and quercetin on laying hen performance, egg quality and egg yolk lipid and protein profiles. A total of 96 Lohmann White laying hens weighing an average of 1500 g at 28 weeks of age were randomly assigned to a basal diet and the basal diet supplemented (0.5 g/kg) with either hesperidin, naringin or quercetin. Each treatment was replicated in 6 cages in an 8-week experimental period. Data were analysed using one-way ANOVA...
July 6, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28675012/-effect-of-naringin-combined-with-bone-morphogenetic-protein-2-on-the-proliferation-and-differentiation-of-mc3t3-e1-cells
#15
Xu Gaoli, Liu Yi, Wu Lili, Shi Qiutao, Huo Guang, Gu Zhiyuan
OBJECTIVE: This study evaluates the biological effects of naringin (NAR) joint bone morphogenetic protein (BMP)-2 on the proliferation, alkaline phosphatase (ALP) activity, and expression of osteoblastogenic genes, such as Runt-related transcription factor 2 (Runx2), collagen Ⅰ (ColⅠ), ALP, and osteocalcin (OCN) of pre-osteoblasts. METHODS: Three different NAR concentrations (10, 100, and 1 000 μmol·L⁻¹) were applied, alone or combined with BMP-2(50 ng·mL⁻¹), to restore the osteoblastogenesis of pre-osteoblasts (MC3T3-E1 cell line)...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28668949/naringin-reverses-neurobehavioral-and-biochemical-alterations-in-intracerebroventricular-collagenase-induced-intracerebral-hemorrhage-in-rats
#16
Navdeep Singh, Yashika Bansal, Ranjana Bhandari, Lovish Marwaha, Raghunath Singh, Kanwaljit Chopra, Anurag Kuhad
Intracerebral hemorrhage (ICH) contributes to 10-15% of all strokes and is a high risk factor for morbidity and mortality as compared to other subtypes of stroke, that is, cerebral ischemia and subarachnoid hemorrhage. Oxidative stress (OS)-induced neuroinflammation and neuronal cell death contribute towards the hallmarks of ICH. Spared antioxidant levels, increased inflammatory cytokines and free radicals in ICH lead to neuronal death and exaggerate the hallmarks of ICH. Intracerebroventricular (ICV) collagenase (COL-induced neuronal cell damage and cognitive deficits form a widely recognized experimental model for ICH...
2017: Pharmacology
https://www.readbyqxmd.com/read/28662177/a-new-approach-for-the-assessment-of-the-toxicity-of-polyphenol-rich-compounds-with-the-use-of-high-content-screening-analysis
#17
Magdalena Boncler, Jacek Golanski, Magdalena Lukasiak, Malgorzata Redzynia, Jaroslaw Dastych, Cezary Watala
The toxicity of in vitro tested compounds is usually evaluated based on AC50 values calculated from dose-response curves. However, there is a large group of compounds for which a standard four-parametric sigmoid curve fitting may be inappropriate for estimating AC50. In the present study, 22 polyphenol-rich compounds were prioritized from the least to the most toxic based on the total area under and over the dose-response curves (AUOC) in relation to baselines. The studied compounds were ranked across three key cell indicators (mitochondrial membrane potential, cell membrane integrity and nuclear size) in a panel of five cell lines (HepG2, Caco-2, A549, HMEC-1, and 3T3), using a high-content screening (HCS) assay...
2017: PloS One
https://www.readbyqxmd.com/read/28635611/modulatory-effects-of-naringin-on-hepatic-key-enzymes-of-carbohydrate-metabolism-in-high-fat-diet-low-dose-streptozotocin-induced-diabetes-in-rats
#18
Leelavinothan Pari, Ramasamy Chandramohan
We evaluated the modulatory effects of naringin on altered hepatic key enzymes of carbohydrate metabolism in high-fat diet/low-dose streptozotocin-induced diabetic rats. Oral treatment of naringin at a doses of 20, 40 and 80 mg/kg body weight to diabetic rats for 30 days resulted in a significant reduction in the levels of plasma glucose, blood glycosylated hemoglobin and increase in the levels of plasma insulin and blood hemoglobin. The altered activities of the hepatic key enzymes of carbohydrate metabolism such as hexokinase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glucose-6-phosphate dehydrogenase, glycogen synthase, glycogen phosphorylase and glycogen content of diabetic rats were significantly reverted to near normal levels by the treatment of naringin in a dose-dependent manner...
July 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/28617100/discovery-of-potent-and-selective-acetylcholinesterase-ache-inhibitors-acacetin-7-o-methyl-ether-mannich-base-derivatives-synthesised-from-easy-access-natural-product-naringin
#19
Hao-Ran Liu, Xue Men, Xiao-Hui Gao, Lin-Bo Liu, Hao-Qun Fan, Xin-Hua Xia, Qiu-An Wang
Naringin, as a component universal existing in the peel of some fruits or medicinal plants, was usually selected as the material to synthesise bioactive derivates since it was easy to gain with low cost. In present investigation, eight new acacetin-7-O-methyl ether Mannich base derivatives (1-8) were synthesised from naringin. The bioactivity evaluation revealed that most of them exhibited moderate or potent acetylcholinesterase (AChE) inhibitory activity. Among them, compound 7 (IC50 for AChE = 0.82 ± 0...
June 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28578029/investigation-of-the-interaction-for-three-citrus-flavonoids-and-%C3%AE-amylase-by-surface-plasmon-resonance
#20
Xia Liu, Fang Luo, Pao Li, Yin She, Wanru Gao
Flavonoids, a class of natural drugs with broad biological activity, exhibit inhibitory effect on α-amylase. Citrus peel is a good source of flavonoids. The real-time interactions between three Citrus flavonoids (naringin, neohesperidin, hesperidin) and α-amylase were investigated by surface plasmon resonance biosensor, and were compared with the α-amylase inhibitors, acarbose. These results showed the binding affinities of naringin, neohesperidin and hesperidin with α-amylase reach the highest at pH6 with KD values of 2...
July 2017: Food Research International
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