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Naringin

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https://www.readbyqxmd.com/read/27904711/naringin-promotes-osteogenic-differentiation-of-bone-marrow-stromal-cells-by-up-regulating-foxc2-expression-via-the-ihh-signaling-pathway
#1
Fei-Xiang Lin, Shi-Xin Du, De-Zhong Liu, Qin-Xiao Hu, Guo-Yong Yu, Chu-Cheng Wu, Gui-Zhou Zheng, Da Xie, Xue-Dong Li, Bo Chang
Naringin is an active compound extracted from Rhizoma Drynariae, and studies have revealed that naringin can promote proliferation and osteogenic differentiation of bone marrow stromal cells (BMSCs). In this study, we explored whether naringin could promote osteogenic differentiation of BMSCs by upregulating Foxc2 expression via the Indian hedgehog (IHH) signaling pathway. BMSCs were cultured in basal medium, basal medium with naringin, osteogenic induction medium, osteogenic induction medium with naringin and osteogenic induction medium with naringin in the presence of the IHH inhibitor cyclopamine (CPE)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27848901/herb-medicines-against-osteoporosis-active-compounds-relevant-biological-mechanisms
#2
Lei Wu, Zhuoyan Ling, Xueqin Feng, Caiping Mao, Zhice Xu
Osteoporosis is one of common bone disorders, affecting millions of people worldwide. Treatments of osteoporosis consist of pharmacotherapy and non-pharmacological interventions, such as mineral supplementation, lifestyle changes, and exercise programs. Due to the minimum side effects and favorable cost-effective therapeutic effects, herbal medicine has been widely applied in clinical practices for more than 2,000 years in China. Of the many traditional formulas reported for treating bone diseases, 4 single herbs namely (1) Herba Epimedii, (2) Rhizoma Drynariae, (3) Fructus Psoraleae, and (4) Cortex Eucommiae, are considered as the featured "Kidney-Yang" tonics, and frequently and effectively applied for preventing and treating osteoporosis...
November 16, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27836465/naringin-regulates-glutamate-nitric-oxide-cgmp-pathway-in-ammonium-chloride-induced-neurotoxicity
#3
Arumugam Ramakrishnan, Natesan Vijayakumar, Mani Renuka
Naringin, plant bioflavonoid extracted mainly from grapefruit and other related citrus species. This study was designed to assess the neuroprotective effect of naringin on ammonium chloride (NH4Cl) induced hyperammonemic rats. Experimental hyperammonemia was induced by intraperitonial injection (i.p) of NH4Cl (100mg/kg body weight (b.w.)) thrice a week for 8 consecutive weeks. Hyperammonemic rats were treated with naringin (80mg/kg b.w.) via oral gavage. Naringin administration drastically restored the levels of blood ammonia, plasma urea, nitric oxide (NO), glutamate, glutamine, lipid peroxidation, lipid profile, activities of liver marker enzymes, antioxidant status and sodium/potassium-ATPase (Na(+)/K(+)-ATPase)...
November 8, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27833010/naringin-promotes-fracture-healing-through-stimulation-of-angiogenesis-by-regulating-the-vegf-vegfr-2-signaling-pathway-in-osteoporotic-rats
#4
Nan Song, Zhihu Zhao, Xinlong Ma, Xiaolei Sun, Jianxiong Ma, Fengbo Li, Lei Sun, Jianwei Lv
Postmenopausal osteoporosis is characterized by a reduction in the number of sinusoidal and arterial capillaries in the bone marrow and reduced bone perfusion. Thus, osteogenesis and angiogenesis are coupled in the process of osteoporosis formation and fracture healing. Naringin is the main ingredient of the root Rhizoma Drynariae, a traditional Chinese medicine, and it has potential effects on promoting fracture healing. However, whether naringin stimulates angiogenesis in the process of bone healing is unclear...
November 8, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27825627/post-acquisition-spectral-stitching-an-alternative-approach-for-data-processing-in-untargeted-metabolomics-by-uhplc-esi-hrms
#5
Eirini Baira, Eleni Siapi, Panagiotis Zoumpoulakis, Deligeorgis Stelios G, Alexios-Leandros Skaltsounis, Evagelos Gikas
INTRODUCTION: In the case of the MS-based metabolomics, the large number of false positives remains a fundamental issue. OBJECTIVE: The aim of this study was to develop a new strategy, which highlights the number of the reliable features i.e. the detected features that correspond to a consistent peak according to chromatographic and mass spectrometric criteria. METHOD: For the analysis blood samples from 20 chickens, which were administrated with naringin and 9 samples from control, were analyzed by UHPLC-HRMS (Orbitrap Velos)...
October 24, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27810393/metabolic-engineering-of-saccharomyces-cerevisiae-for-de-novo-production-of-dihydrochalcones-with-known-antioxidant-antidiabetic-and-sweet-tasting-properties
#6
Michael Eichenberger, Beata Joanna Lehka, Christophe Folly, David Fischer, Stefan Martens, Ernesto Simón, Michael Naesby
Dihydrochalcones are plant secondary metabolites comprising molecules of significant commercial interest as antioxidants, antidiabetics, or sweeteners. To date, their heterologous biosynthesis in microorganisms has been achieved only by precursor feeding or as minor by-products in strains engineered for flavonoid production. Here, the native ScTSC13 was overexpressed in Saccharomyces cerevisiae to increase its side activity in reducing p-coumaroyl-CoA to p-dihydrocoumaroyl-CoA. De novo production of phloretin, the first committed dihydrochalcone, was achieved by co-expression of additional relevant pathway enzymes...
October 31, 2016: Metabolic Engineering
https://www.readbyqxmd.com/read/27808514/variation-in-key-flavonoid-biosynthetic-enzymes-and-phytochemicals-in-rio-red-grapefruit-citrus-paradisi-macf-during-fruit-development
#7
Priyanka R Chaudhary, Haejeen Bang, Guddadarangavvanahally K Jayaprakasha, Bhimanagouda S Patil
In the current study, phytochemical contents and expression of genes involved in flavonoid biosynthesis in Rio Red grapefruit were studied at different developmental and maturity stages for the first time. Grapefruit were harvested in June, August, November, January, and April and analyzed for the levels of carotenoids, vitamin C, limonoids, flavonoids, and furocoumarins by HPLC. In addition, genes encoding for phenylalanine ammonia lyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI) and 1, 2-rhamnosyltransferase (2RT) were isolated and their expression in grapefruit juice vesicles was studied...
November 3, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27771282/phytochemical-mediated-modulation-of-the-expression-and-transporter-function-of-breast-cancer-resistance-protein-at-the-blood-brain-barrier-an-in-vitro-study
#8
Manjit Kaur, Raj K S Badhan
Clinical translation of BCRP inhibitors have failed due to neurotoxicity and novel approaches are required to identify suitable modulators of BCRP to enhance CNS drug delivery. In this study we examine 18 compounds, primarily phytochemicals, as potential novel modulators of AhR-mediated regulation of BCRP expression and function in immortalised and primary porcine brain microvascular endothelial cells as a mechanism to enhance CNS drug delivery. The majority of modulators possessed a cellular viability IC50 > 100µM in both cell systems...
October 19, 2016: Brain Research
https://www.readbyqxmd.com/read/27760293/non-covalent-interactions-between-superoxide-dismutase-and-flavonoids-studied-by-native-mass-spectrometry-combined-with-molecular-simulations
#9
Xiaoyu Zhuang, Bing Zhao, Shu Liu, Fengrui Song, Fengchao Cui, Zhiqiang Liu, Yunqi Li
Misfolding and aggregation of Cu, Zn superoxide dismutase (SOD1) is implicated in the etiology amyotrophic lateral sclerosis (ALS). The use of small molecules may stabilize the spatial structure of SOD1 dimer, thus preventing its dissociation and aggregation. In this study, "native" mass spectrometry (MS) was used to study the non-covalent interactions between SOD1 and flavonoid compounds. MS experiments were performed on a quadruple time-of-flight (Q-ToF) mass spectrometer with an electrospray ionization (ESI) source and T-wave ion mobility...
October 19, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27744636/identification-of-naringin-metabolites-in-human-urine-and-feces
#10
Xuan Zeng, Yang Bai, Wei Peng, Weiwei Su
BACKGROUND AND OBJECTIVES: Naringin, an active flavanone glycoside, has been widely considered as a prospective antitussive and expectorant. The present study aimed to elucidate the metabolic profile of naringin in the human body. METHODS: Four male and three female volunteers (20-30 years old and 18.8-21.7 kg/m(2) Body Mass Index) were orally administrated 320 mg naringin; their urine and feces were collected at different times and the corresponding metabolites were identified with a high resolution ultra-fast liquid chromatography-quadrupole-time-of-flight tandem mass spectrometry (UFLC-Q-TOF-MS/MS) system...
October 15, 2016: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27739344/inhibition-of-periodontitis-induction-using-a-stimuli-responsive-hydrogel-carrying-naringin
#11
Po-Chun Chang, Yi-Chi Chao, Meng-Hsuan Hsiao, Hao-Syun Chou, Yi-Han Jheng, Xin-Hong Yu, Ning Lee, Connie Yang, Dean-Mo Liu
BACKGROUND: Developing a drug carrier with favorable handling characteristics that can respond to environmental changes following inflammation, such as pH changes, may be beneficial for treating periodontitis. This study aimed to investigate the preclinical feasibility of using naringin, a naturally derived polymethoxylated flavonoid compound with anti-inflammatory properties, to inhibit periodontitis induction via a thermo-gelling and pH-responsive injectable hydrogel. METHODS: The hydrogel was made of amphipathic carboxymethyl-hexanoyl chitosan (CHC), beta glycerol-phosphate (β-GP), and glycerol, and the thermo-gelling and pH-responsive characteristics of the hydrogel as well as the cell viability after treatment with the hydrogel containing naringin were evaluated in vitro...
October 14, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27736690/dynamic-metabolic-profile-of-zhi-zi-da-huang-decoction-in-rat-urine-based-on-hybrid-liquid-chromatography-mass-spectrometry-coupled-with-solid-phase-extraction
#12
Juanjuan Wang, Qingshui Shi, Chunyong Wu, Fang Feng
Zhi-Zi-Da-Huang decoction (ZZDHD) has been used for treatment of alcoholic liver disease in China for thousands of years. In order to reveal the dynamic biotransformation of the decoction in vivo, a high-throughout, sensitive and special method based on high performance liquid chromatography coupled with diode array detection and time-of-flight mass spectrometry (HPLC-DAD-TOF/MS) and high performance liquid chromatography coupled with triple quadrupole mass spectrometry (HPLC-QqQ/MS) was developed and validated...
November 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27716835/naringin-decreases-tnf-%C3%AE-and-hmgb1-release-from-lps-stimulated-macrophages-and-improves-survival-in-a-clp-induced-sepsis-mice
#13
Minchan Gil, Yun Kyu Kim, Sang Bum Hong, Kyung Jin Lee
Naringin, a flavanone glycoside extracted from various plants, has a wide range of pharmacological effects. In the present study, we investigated naringin's mechanism of action and its inhibitory effect on lipopolysaccharide-induced tumor necrosis factor-alpha and high-mobility group box 1 expression in macrophages, and on death in a cecal ligation and puncture induced mouse model of sepsis. Naringin increased heme oxygenase 1 expression in peritoneal macrophage cells through the activation of adenosine monophosphate-activated protein kinase, p38, and NF-E2-related factor 2...
2016: PloS One
https://www.readbyqxmd.com/read/27716530/naringin-protects-against-lipopolysaccharide-induced-cardiac-injury-in-mice
#14
Liu Xianchu, Professor Zheng Lan, Li Qiufang, Liu Yi, Ruan Xiangcheng, Hou Wenqi, Ding Yang
Previous research has demonstrated that lipopolysaccharide (LPS) can induce sepsis and lead to myocardial dysfunction. Naringin has various biological activities in LPS-induced sepsis. In this study, our aim was to investigate the effects of Naringin on LPS-induced cardiac injury and clarify its potential mechanism. We found that in vivo treatment with Naringin significantly ameliorated body weight loss, and attenuated cardiac histopathological changes after LPS challenge. Furthermore, Naringin inhibited LPS-induced increase of TNF-α, IL-1β and IL-6 activities to alleviate inflammatory response in heart...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27687505/naringin-in-ganshuang-granule-suppresses-activation-of-hepatic-stellate-cells-for-anti-fibrosis-effect-by-inhibition-of-mammalian-target-of-rapamycin
#15
Hongbo Shi, Honglin Shi, Feng Ren, Dexi Chen, Yu Chen, Zhongping Duan
A previous study has demonstrated that Ganshuang granule (GSG) plays an anti-fibrotic role partially by deactivation of hepatic stellate cells (HSCs). In HSCs activation, mammalian target of rapamycin (mTOR)-autophagy plays an important role. We attempted to investigate the role of mTOR-autophagy in anti-fibrotic effect of GSG. The cirrhotic mouse model was prepared to demonstrate the anti-fibrosis effect of GSG. High performance liquid chromatography (HPLC) analyses were used to identify the active component of GSG...
September 30, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27665317/copper-ii-and-zinc-ii-complexes-with-flavanone-derivatives-identification-of-potential-cholinesterase-inhibitors-by-on-flow-assays
#16
André Lucio Franceschini Sarria, Adriana Ferreira Lopes Vilela, Bárbara Mammana Frugeri, João Batista Fernandes, Rose Maria Carlos, Maria Fátima das Graças Fernandes da Silva, Quezia Bezerra Cass, Carmen Lúcia Cardoso
Metal chelates strongly influence the nature and magnitude of pharmacological activities in flavonoids. In recent years, studies have shown that a promising class of flavanone-metal ion complexes can act as selective cholinesterase inhibitors (ChEIs), which has led our group to synthesize a new series of flavanone derivatives (hesperidin, hesperetin, naringin, and naringenin) complexed to either copper (II) or zinc (II) and to evaluate their potential use as selective ChEIs. Most of the synthesized complexes exhibited greater inhibitory activity against acetylcholinesterase (AChE) than against butyrylcholinesterase (BChE)...
September 17, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27664614/changes-of-phenolic-acids-and-vitamin-e-profiles-on-germinated-rough-rice-oryza-sativa-l-treated-by-high-hydrostatic-pressure
#17
Min Young Kim, Sang Hoon Lee, Gwi Yeong Jang, Meishan Li, Youn Ri Lee, Junsoo Lee, Heon Sang Jeong
This study was performed to investigate changes in the phenolic acid and vitamin E profiles of germinated rough rice following high hydrostatic pressure treatment (HPT). Rough rice was germinated at 37°C for two days and subjected to 0.1, 10, 30, 50, and 100MPa pressures for 24h. The total phenolic acid content increased from 85.37μg/g at 0.1MPa to 183.52μg/g at 100MPa. The highest gallic acid (4.29μg/g), catechin (9.55μg/g), p-coumaric acid (8.36μg/g), ferulic acid (14.99μg/g), salicylic acid (14.88μg/g), naringin (6...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27616636/antiplatelet-activity-of-flavonoid-and-coumarin-drugs
#18
Cristina Zaragozá Arnaéz, Jorge Monserrat Sanz, Carolina Mantecón Ramiro, Lucinda Villaescusa Castillo, Francisco Zaragozá García, Melchor Álvarez de Mon Soto
Polyphenols are used as phlebotonic drugs, but their mechanism of action remains unknown. Since platelet activity and platelet-endothelial cell interactions are involved in the pathogenesis of cardiovascular disease, this work examines whether different flavonoid and coumarin drugs are able to inhibit platelet aggregation. This specific case of coumarins, the antiplatelet effect is not linked with a possible interaction over blood coagulation since this effect only dicoumarols have it. The antiplatelet capacity of polyphenols was assayed using peripheral blood platelets from healthy controls...
September 8, 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27603739/nmr-tube-degradation-method-for-sugar-analysis-of-glycosides
#19
José-Luis Giner, Ju Feng, David J Kiemle
The sugar subunits of natural glycosides can be conveniently determined by acid hydrolysis and (1)H NMR spectroscopy without isolation or derivatization. The chemical shifts, coupling constants, and integral ratios of the anomeric signals allow each monosaccharide to be identified and its molar ratio to other monosaccharides to be quantified. The NMR data for the anomeric signals of 28 monosaccharides and three disaccharides are reported. Application of the method is demonstrated with the flavonoid glycoside naringin (1), the aminoglycoside antibiotics kanamycin (2) and tobramycin (3), and the saponin digitonin (4)...
September 23, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27584687/naringenin-ameliorates-kainic-acid-induced-morphological-alterations-in-the-dentate-gyrus-in-a-mouse-model-of-temporal-lobe-epilepsy
#20
Jungha Park, Kyoung Hoon Jeong, Won-Ho Shin, Young-Seuk Bae, Un Ju Jung, Sang Ryong Kim
Granule cell dispersion (GCD) in the dentate gyrus (DG) of the hippocampus is a morphological alteration characteristic of temporal lobe epilepsy. Recently, we reported that treatment with naringin, a flavonoid found in grapefruit and citrus fruits, reduced spontaneous recurrent seizures by inhibiting kainic acid (KA)-induced GCD and neuronal cell death in mouse hippocampus, suggesting that naringin might have beneficial effects for preventing epileptic events in the adult brain. However, it is still unclear whether the beneficial effects of naringin treatment are mediated by the metabolism of naringin into naringenin in the KA-treated hippocampus...
October 19, 2016: Neuroreport
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