keyword
https://read.qxmd.com/read/34788673/ultra-high-pressure-liquid-chromatography-coupled-to-travelling-wave-ion-mobility-time-of-flight-mass-spectrometry-for-the-screening-of-pharmaceutical-metabolites-in-wastewater-samples-application-to-antiretrovirals
#21
JOURNAL ARTICLE
Tlou T Mosekiemang, Maria A Stander, André de Villiers
The presence of pharmaceutical compounds in the aquatic environment is a significant environmental health concern, which is exacerbated by recent evidence of the contribution of drug metabolites to the overall pharmaceutical load. In light of a recent report of the occurrence of metabolites of antiretroviral drugs (ARVDs) in wastewater, we investigate in the present work the occurrence of further ARVD metabolites in samples obtained from a domestic wastewater treatment plant in the Western Cape, South Africa...
December 20, 2021: Journal of Chromatography. A
https://read.qxmd.com/read/34557694/uhl-s-anomaly-with-left-ventricular-noncompaction-role-of-multimodality-imaging-in-a-rare-association
#22
Adeba Mohammad, Purvi Parwani, Carlo Manalo, Brent M Gordon, Ahmed Kheiwa
Uhl's anomaly is a rare congenital heart disease characterized by partial or complete absence of the right ventricle myocardium. We report the first case, in a 21-year-old man, of Uhl's anomaly-associated left ventricular noncompaction. This association represents a unique clinical entity and has important implications for management strategies. ( Level of Difficulty: Intermediate. ).
September 15, 2021: JACC. Case reports
https://read.qxmd.com/read/34384806/atherosclerotic-renovascular-disease-a-kdigo-kidney-disease-improving-global-outcomes-controversies-conference
#23
JOURNAL ARTICLE
Caitlin W Hicks, Timothy W I Clark, Christopher J Cooper, Áine M de Bhailís, Marco De Carlo, Darren Green, Jolanta Małyszko, Marius Miglinas, Stephen C Textor, Charles A Herzog, Kirsten L Johansen, Holger Reinecke, Philip A Kalra
The diagnosis and management of atherosclerotic renovascular disease (ARVD) is complex and controversial. Despite evidence from the ASTRAL (2009) and CORAL (2013) randomized controlled trials showing that percutaneous renal artery revascularization did not improve major outcomes compared with best medical therapy alone over 3-5 years, several areas of uncertainty remain. Medical therapy, including statin and antihypertensive medications, has evolved in recent years, and the use of renin-angiotensin-aldosterone system blockers is now considered the primary means to treat hypertension in the setting of ARVD...
February 2022: American Journal of Kidney Diseases
https://read.qxmd.com/read/34262479/cullin-deneddylation-suppresses-the-necroptotic-pathway-in-cardiomyocytes
#24
Megan T Lewno, Taixing Cui, Xuejun Wang
Cardiomyocyte death in the form of apoptosis and necrosis represents a major cellular mechanism underlying cardiac pathogenesis. Recent advances in cell death research reveal that not all necrosis is accidental, but rather there are multiple forms of necrosis that are regulated. Necroptosis, the earliest identified regulated necrosis, is perhaps the most studied thus far, and potential links between necroptosis and Cullin-RING ligases (CRLs), the largest family of ubiquitin E3 ligases, have been postulated...
2021: Frontiers in Physiology
https://read.qxmd.com/read/34189007/can-smartwatch-prevent-sudden-cardiac-deaths-a-case-of-smartwatch-failure-in-arrhythmogenic-right-ventricular-dysplasia
#25
Sengottaian Sivakumar, Navdeep Bhatti
Arrhythmogenic right ventricular dysplasia (ARVD) is caused by mutations in genes coding for components of desmosomes in the myocardium. Mutations in these genes make desmosomes dysfunctional and account for myocyte detachment, followed by inflammation and apoptosis when it encounters undue mechanical stress. This is why ARVD is a common cause of sudden cardiac death in athletes with undiagnosed ARVD, as increased physical activity exacerbates this progression of ARVD and associated arrhythmias. We describe a case of ARVD in a 36-year-old woman who presented with an unusual sensation in her chest due to non-sustaining ventricular tachycardia, which her smartwatch failed to pick up...
June 24, 2021: Curēus
https://read.qxmd.com/read/34087998/an-induced-pluripotent-stem-cell-line-ehtjui004-a-generated-from-a-neonate-with-c-4683_4684delct-p-leu1563fs-mutation-in-the-gene-dsp-causing-familial-arrhythmogenic-right-ventricular-dysplasia-arvd
#26
JOURNAL ARTICLE
Yi-Yao Qi, Ji-Zhen Lu, Lu Zhang, Hong-Xia Cao, Han-Yu Zhu, Zhi-Hui Bai, Shou-Mei Zhang, Zhi-Bin Qiao, Wen-Wen Jia, Zhong-Min Liu
Familial Arrhythmogenic Right Ventricular Dysplasia (ARVD) is a primary cardiomyopathy characterized by the abnormality of the right ventricular muscle. ARVD may be life-threatening due to the induction of paroxysmal refractory ventricular tachycardia or supraventricular arrhythmia. A human induced pluripotent stem cell line (EHTJUi004-A) was generated from human umbilical cord blood mononuclear cells (UCBMCs) of a female neonate with heterozygous mutation of p.Leu1563fs (c.4683_4684delCT) in the DSP gene. This iPS cell line resource provides an ideal in vitro model to study the pathological mechanism of ARVD...
May 2021: Stem Cell Research
https://read.qxmd.com/read/34033688/antiretroviral-drugs-in-african-surface-waters-prevalence-analysis-and-potential-remediation
#27
REVIEW
Adedapo O Adeola, Patricia B C Forbes
The sources, ecotoxicological impact, and potential remediation strategies of antiretroviral drugs (ARVDs) as emerging contaminants in surface waters are reviewed based on recent literature. The occurrence of ARVDs in water bodies raises concern because many communities in Africa depend on rivers for water resources. Southern Africa is a potential hotspot regarding ARVD contamination due to relatively high therapeutic application and detection thereof in water bodies. Efavirenz and nevirapine are the most persistent in effluents and are prevalent in surface water based on environmental concentrations...
February 2022: Environmental Toxicology and Chemistry
https://read.qxmd.com/read/34026494/epicardial-access-facilitated-by-carbon-dioxide-insufflation-for-redo-ventricular-tachycardia-ablation-in-a-patient-with-arrhythmogenic-right-ventricular-dysplasia-and-dense-adhesions
#28
Jordan S Leyton-Mange, Edward Y Sze, Christina Conley, Samip C Vasaiwala, Henry W Sesselberg
No abstract text is available yet for this article.
April 2021: HeartRhythm Case Reports
https://read.qxmd.com/read/34011348/left-ventricular-fibro-fatty-replacement-in-arrhythmogenic-right-ventricular-dysplasia-cardiomyopathy-prevalence-patterns-and-association-with-arrhythmias
#29
JOURNAL ARTICLE
Tarek Zghaib, Anneline S J M Te Riele, Cynthia A James, Neda Rastegar, Brittney Murray, Crystal Tichnell, Marc K Halushka, David A Bluemke, Harikrishna Tandri, Hugh Calkins, Ihab R Kamel, Stefan Loy Zimmerman
BACKGROUND: Left ventricular (LV) fibrofatty infiltration in arrhythmogenic right ventricular (RV) dysplasia/cardiomyopathy (ARVD/C) has been reported, however, detailed cardiovascular magnetic resonance (CMR) characteristics and association with outcomes are uncertain. We aim to describe LV findings on CMR in ARVD/C patients and their relationship with arrhythmic outcomes. METHODS: CMR of 73 subjects with ARVD/C according to the 2010 Task Force Criteria (TFC) were analyzed for LV involvement, defined as ≥ 1 of the following features: LV wall motion abnormality, LV late gadolinium enhancement (LGE), LV fat infiltration, or LV ejection fraction (LVEF) < 50%...
May 20, 2021: Journal of Cardiovascular Magnetic Resonance
https://read.qxmd.com/read/34007738/arrhythmogenic-right-ventricular-dysplasia-and-brugada-syndrome-overlap
#30
Hussein Rabah, Ali Rabah
Arrhythmogenic right ventricular dysplasia (ARVD) and Brugada syndrome( BS) are associated with an increased risk of sudden cardiac death. Although they are described as two different entities, research suggests that they are not entirely separate. This paper presents a 55 years old male who presented for syncope. Interestingly, his electrocardiogram met the diagnostic criteria for both ARVD and BS. Subsequently, an implantable cardioverter-defibrillator (ICD) was implanted before discharge due to his high risk of sudden cardiac death...
April 14, 2021: Curēus
https://read.qxmd.com/read/33857019/desmosomal-cop9-regulates-proteome-degradation-in-arrhythmogenic-right-ventricular-dysplasia-cardiomyopathy
#31
JOURNAL ARTICLE
Yan Liang, Robert C Lyon, Jason Pellman, William H Bradford, Stephan Lange, Julius Bogomolovas, Nancy D Dalton, Yusu Gu, Marcus Bobar, Mong-Hong Lee, Tomoo Iwakuma, Vishal Nigam, Angeliki Asimaki, Melvin Scheinman, Kirk L Peterson, Farah Sheikh
Dysregulated protein degradative pathways are increasingly recognized as mediators of human disease. This mechanism may have particular relevance to desmosomal proteins that play critical structural roles in both tissue architecture and cell-cell communication, as destabilization/breakdown of the desmosomal proteome is a hallmark of genetic-based desmosomal-targeted diseases, such as the cardiac disease arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). However, no information exists on whether there are resident proteins that regulate desmosomal proteome homeostasis...
June 1, 2021: Journal of Clinical Investigation
https://read.qxmd.com/read/33789750/mesenchymal-stem-cells-and-extracellular-vesicles-in-therapy-against-kidney-diseases
#32
REVIEW
Yuling Huang, Lina Yang
Kidney diseases pose a threat to human health due to their rising incidence and fatality rate. In preclinical and clinical studies, it has been acknowledged that mesenchymal stem cells (MSCs) are effective and safe when used to treat kidney diseases. MSCs play their role mainly by secreting trophic factors and delivering extracellular vesicles (EVs). The genetic materials and proteins contained in the MSC-derived EVs (MSC-EVs), as an important means of cellular communication, have become a research focus for targeted therapy of kidney diseases...
March 31, 2021: Stem Cell Research & Therapy
https://read.qxmd.com/read/33743362/generation-of-three-induced-pluripotent-stem-cell-lines-scvii003-a-scvii004-a-scvii005-a-from-patients-with-arvd-c-caused-by-heterozygous-mutations-in-the-pkp2-gene
#33
JOURNAL ARTICLE
James W S Jahng, Katelyn E Black, Lichao Liu, Hye Ryeong Bae, Marco Perez, Euan A Ashley, Karim Sallam, Joseph C Wu
Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited heart disease which can cause life-threatening ventricular arrhythmias and cardiac dysfunction. The autosomal dominant form of ARVD/C is caused by mutations in the cardiac desmosome, such as those in the plakoglobin plakophilin-2 (PKP2) gene. Here, we generated three human induced pluripotent stem cell (iPSC) lines from the peripheral blood mononuclear cells (PBMCs) of three ARVD/C patients carrying pathogenic variants in their PKP2 genes (c...
May 2021: Stem Cell Research
https://read.qxmd.com/read/33418261/uptake-accumulation-and-impact-of-antiretroviral-and-antiviral-pharmaceutical-compounds-in-lettuce
#34
JOURNAL ARTICLE
Preston Akenga, Antony Gachanja, Mark F Fitzsimons, Alan Tappin, Sean Comber
While the contamination of agroecosystems with pharmaceutical compounds has been reported, the fate of these compounds, particularly uptake into plants remains unclear. This lack of environmental fate data is evident for a critical class of pharmaceuticals, the antivirals and antiretrovirals (ARVDs). Thus, this study evaluated the root uptake of the antiretroviral compounds nevirapine, lamivudine and efavirenz, and the antiviral compound oseltamivir in lettuce. The lettuce was hydroponically grown in a nutrient solution containing the four ARVD pharmaceutical mixture in the 1-100 μg L-1 concentration range...
December 24, 2020: Science of the Total Environment
https://read.qxmd.com/read/33324513/clinical-manifestations-and-diagnostic-approach-to-arrhythmogenic-right-ventricular-cardiomyopathy-a-case-report-and-literature-review
#35
Raja S Mushtaque, Rabia Mushtaque, Shahbano Baloch, Muhammad Idrees, Haseeb Bhatti
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare inherited disorder, which is characterized by fibrofatty degeneration of cardiac muscles mainly in the right ventricular myocardium. It may cause tachyarrhythmias or right-heart failure or may cause sudden death, especially in young athletes. In our case report, we present a case of young age male patient who presented at a local community hospital with the complaint of atypical chest pain, palpitations, and vomiting and sustained ventricular tachycardia (VT) on electrocardiograph (ECG) showing sustained VT, left bundle branch morphology with the superior axis...
November 10, 2020: Curēus
https://read.qxmd.com/read/33224778/right-ventricular-dysfunction-and-long-term-risk-of-death
#36
REVIEW
Jason L Sanders, Martin Koestenberger, Stephan Rosenkranz, Bradley A Maron
Sudden cardiac death (SCD), or sudden loss of life-sustaining systemic and cerebral perfusion, is most often due to left ventricular (LV) dysfunction secondary to ischemic or structural cardiac disease or channelopathies. Degeneration of sinus rhythm into ventricular tachycardia and ultimately ventricular fibrillation is the final common pathway for most heart failure patients. Right ventricular (RV) dysfunction is recognized as an independent contributor to worsening heart failure. There is emerging evidence that RV dysfunction may also be an independent predictor of SCD...
October 2020: Cardiovascular Diagnosis and Therapy
https://read.qxmd.com/read/32659557/mass-loading-distribution-and-removal-of-antibiotics-and-antiretroviral-drugs-in-selected-wastewater-treatment-plants-in-kenya
#37
JOURNAL ARTICLE
Cecilia Muriuki, Pius Kairigo, Patrick Home, Elijah Ngumba, James Raude, Anthony Gachanja, Tuula Tuhkanen
The discharge of active pharmaceutical ingredients (APIs) into the aquatic environment from wastewater effluents is a concern in many countries. Although many studies have been conducted to evaluate the APIs removal efficiencies and emissions to the environment in wastewater treatment plants (WWTPs), most of these studies considered the aqueous and sludge phases, disregarding the suspended particulate matter (SPM) phase. To try to understand the role of the SPM, the occurrence of five most common antibiotics and three antiretroviral drugs (ARVDs) commonly used in Kenya were investigated in this study...
July 6, 2020: Science of the Total Environment
https://read.qxmd.com/read/32657137/long-term-outcome-after-ventricular-tachycardia-ablation-in-nonischemic-cardiomyopathy-late-potential-abolition-and-vt-noninducibility
#38
JOURNAL ARTICLE
Kenji Okubo, Lorenzo Gigli, Nicola Trevisi, Luca Foppoli, Andrea Radinovic, Caterina Bisceglia, Antonio Frontera, Giuseppe D'Angelo, Manuela Cireddu, Gabriele Paglino, Patrizio Mazzone, Paolo Della Bella
BACKGROUND: In patients with an ischemic cardiomyopathy (ICM), the combination of late potential (LP) abolition and postprocedural ventricular tachycardia (VT) noninducibility is known to be the desirable end point for a successful long-term outcome after VT ablation. We investigated whether LP abolition and VT noninducibilty have a similar impact on the outcomes of patients with non-ICMs (NICM) undergoing VT ablation. METHODS: A total of 403 patients with NICM (523 procedures) who underwent a VT ablation from 2010 to 2016 were included...
August 2020: Circulation. Arrhythmia and Electrophysiology
https://read.qxmd.com/read/32465911/safety-and-feasibility-of-home-inr-monitoring-for-outpatient-ventricular-assist-device-support-in-children
#39
JOURNAL ARTICLE
B M Hawkins, C Ventresco, A Hellinger, C VanderPluym, C Knoll
PURPOSE: The use of intracorporeal continuous flow (CF) ventricular assist devices- namely the Heartware™ HVAD™- has expanded dramatically in the children, with many being discharged home. We sought to evaluate the feasibility and outcomes of children discharged home with point of care (POC) INR monitors for their warfarin anticoagulation management. METHODS: This is a retrospective single center review of all pediatric patients, aged ≤19 years at time of implantation, who were discharged home for longer than 1 week...
April 2020: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/32444857/kidney-enlargement-effect-of-angioplasty-for-nonatherosclerotic-renovascular-disease-reversibility-of-ischemic-kidney
#40
JOURNAL ARTICLE
Tomoyuki Iwasaki, Eikan Mishima, Takehiro Suzuki, Koichi Kikuchi, Takafumi Toyohara, Kazumasa Seiji, Kei Takase, Mariko Miyazaki, Hideo Harigae, Sadayoshi Ito, Takaaki Abe
Renal artery stenosis causes kidney ischemia, reducing the size of the affected kidney, which eventually results in atrophy. Although renal atrophy is considered irreversible, resolution of the ischemia occasionally restores kidney size when the cause is renal artery stenosis. Angioplasty is effective in patients with nonatherosclerotic renovascular diseases (non-ARVDs). Nevertheless, renal enlargement after angioplasty has not been fully examined. We conducted a retrospective study to examine this phenomenon in non-ARVD patients...
May 22, 2020: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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