Aigbe Gregory Ohihoin, Esther Ngozi Ohihoin, Ifeoma Ujomu, Airat Bakare, Oladeji Olanrewaju, Arinze Okafor, Mercy Ojetunde, Joy Boluwatife Ayoola, Oluwagbemiga Aina, Olusola Ajibaye, Simon D Taylor-Robinson
INTRODUCTION: There are genuine concerns that long-term use of anti-retroviral drugs may be associated with reproductive complications in females. This study aimed to ascertain the effect of highly active anti-retroviral drugs on the ovarian reserve and reproductive potential of female Wistar rats and by extension to HIV-positive human females. METHODS: A total of 25 female Wistar rats, weighing between 140g and 162g, were randomly allotted into non-intervention and intervention groups, receiving the anti-retroviral drugs, Efavirenz (EFV), Tenofovir Disoproxil Fumarate (TDF), Lamivudine (3TC), and a fixed-dose combination (FDC)...
2023: Journal of Experimental Pharmacology