keyword
https://read.qxmd.com/read/37518823/ultrasound-guided-injections-in-ankle-and-foot
#21
JOURNAL ARTICLE
Fernando Ruiz Santiago, Beatriz Moraleda Cabrera, Antonio Jesús Láinez Ramos-Bossini
Ultrasound guidance is particularly useful for percutaneous injections in the diagnosis and management of painful conditions of the ankle and foot. The injectates used include steroids and local anesthetics, such as lidocaine, mepivacaine, bupivacaine, ropivacaine, and platelet-rich plasma. Osteoarthritis is the main indication for joint injections. Joints amenable to being injected include the tibiotalar, subtalar, midtarsal, and metatarsophalangeal joints. Tendon injections mainly involve the Achilles, peroneus, extensors, and tibialis tendons, while plantar fascia injections are useful for treating plantar fasciitis and plantar fibromatosis...
July 30, 2023: Journal of Ultrasound
https://read.qxmd.com/read/37483085/evaluation-of-frontal-and-infratrochlear-nerve-blocks-for-standing-sedated-frontonasal-sinusotomy-in-horses
#22
JOURNAL ARTICLE
Singen M Elliott, Shyla C Giancola, Valerie Moorman
OBJECTIVE: To determine if targeted blocking of frontal and infratrochlear nerves provided anesthesia for the approach to a frontonasal sinusotomy. STUDY DESIGN: Two part study: Part 1 randomized crossover design; Part 2 proof of concept. ANIMALS: N = 12; six each in Parts 1 and 2. METHODS: Part 1: Each horse had either frontal and infratrochlear nerve blocks or a line block performed with 2% mepivacaine hydrochloride...
July 22, 2023: Veterinary Surgery
https://read.qxmd.com/read/37463601/implanting-impella-5-5-under-local-anesthesia
#23
JOURNAL ARTICLE
Kaveh Eghbalzadeh, Thorsten C W Wahlers, Antje Christin Deppe
BACKGROUND:  Surgically implanted Impella 5.5. delivers full cardiac support and left ventricular unloading for patients with heart failure. So far, the Impella device is implanted under general anesthesia (GA). MATERIAL AND METHODS:  A total of n  = 3 critically ill patients presented with acute heart failure in need of cardiac support. All patients suffered cardiogenic shock of varying etiology. Due to hemodynamically unstable conditions, GA was avoided...
August 11, 2023: Thoracic and Cardiovascular Surgeon
https://read.qxmd.com/read/37433742/transitioning-from-intrathecal-bupivacaine-to-mepivacaine-for-same-day-discharge-total-joint-arthroplasty-a-quality-improvement-study
#24
JOURNAL ARTICLE
Peter W Coleman, Tyler C Underriner, Victoria M Kennerley, Kyle D Marshall
INTRODUCTION: Same-day discharge total knee and hip arthroplasty is becoming more common. Anesthetic approaches that optimize readiness for discharge are important. Based on an institutional change from low-dose bupivacaine to mepivacaine, we aimed to assess the impact on postanesthesia care unit (PACU) recovery in a quaternary care, academic medical center. METHODS: In this quality improvement retrospective study, a single surgeon performed 96 combined total knee and hip arthroplasties booked as same-day discharge from September 20, 2021 to December 20, 2021...
July 11, 2023: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/37416846/a-randomized-triple-blinded-controlled-clinical-study-with-a-novel-disease-modifying-drug-combination-in-equine-lameness-associated-osteoarthritis
#25
JOURNAL ARTICLE
E Skiöldebrand, S Adepu, C Lützelschwab, S Nyström, A Lindahl, K Abrahamsson-Aurell, E Hansson
OBJECTIVE: This study aimed to test a novel treatment combination (TC) (equivalent to sildenafil, mepivacaine, and glucose) with disease-modifying properties compared to Celestone® bifas® (CB) in a randomized triple-blinded phase III clinical study in horses with mild osteoarthritis (OA). Joint biomarkers (reflecting the articular cartilage and subchondral bone remodelling) and clinical lameness were used as readouts to evaluate the treatment efficacy. METHODS: Twenty horses with OA-associated lameness in the carpal joint were included in the study and received either TC ( n =  10) or CB ( n =  10) drug intra-articularly-twice in the middle carpal joint with an interval of 2 weeks (visit 1 & 2)...
September 2023: Osteoarthritis and cartilage open
https://read.qxmd.com/read/37386676/opioid-sparing-effect-of-intravenous-dexmedetomidine-in-orthopaedic-surgery-a-retrospective-analysis
#26
JOURNAL ARTICLE
Valerio Donatiello, Aniello Alfieri, Andrea Napolitano, Vincenzo Maffei, Francesco Coppolino, Vincenzo Pota, Maria Beatrice Passavanti, Maria Caterina Pace, Pasquale Sansone
BACKGROUND: Dexmedetomidine is a highly selective alpha-2 receptor agonist without any effect on the GABA receptor. It provides an excellent sedative and analgesic profile with few side effects. We report our experience with dexmedetomidine use during orthopaedic surgery under locoregional anaesthesia to ensure adequate sedation and optimal postoperative pain control. METHODS: In this retrospective analysis, we included 128 patients who underwent orthopaedic surgery between January 2019 and December 2021...
December 19, 2022: J Anesth Analg Crit Care
https://read.qxmd.com/read/37332132/effects-of-subconjunctival-ropivacaine-liposomal-bupivacaine-and-mepivacaine-on-corneal-sensitivity-in-healthy-horses
#27
JOURNAL ARTICLE
Gabriel A Gonzalez, Caroline Betbeze, Robert Wills, Alison Eddy, Cathleen Mochal-King, Robin L Fontenot
OBJECTIVE: To evaluate corneal sensitivity and adverse events following subconjunctival administration of three local anesthetics in horses. STUDY DESIGN: Randomized, masked, crossover study. ANIMALS: Twelve healthy adult mares. METHODS: The subconjunctival space of the treated eye was injected with 0.2 mL of liposomal bupivacaine (1.3%), ropivacaine (0.5%), or mepivacaine (2%). All horses received each medication once and the contralateral eye received saline (control)...
June 18, 2023: Veterinary Surgery
https://read.qxmd.com/read/37313269/allergic-reactions-to-local-anesthetic-mepivacaine-in-dental-procedures-a-case-report
#28
Yoonhyoung Nam, Seyeon Min, Wonse Park, Kee-Deog Kim
Local anesthetics are an essential part of pain control during dental treatment. Despite its effectiveness and safety, patients should constantly be aware of potential adverse effects, including allergic reactions. Allergic reactions to amide-type local anesthetics (LAs), such as lidocaine and mepivacaine, are rare compared to those to ester-type LAs. Herein, we report the case of a patient with a history of allergy to lidocaine and mepivacaine, with symptoms of itching, diffuse erythema of the wrists and hands, dizziness, and pectoralgia...
June 2023: Journal of Dental Anesthesia and Pain Medicine
https://read.qxmd.com/read/37231720/local-anesthetics-clinical-uses-and-toxicity-recognition-and-management
#29
JOURNAL ARTICLE
Sedat Ozbay, Mustafa Ayan, Ozgur Karcioglu
Local anesthetic (LA) compounds decrease the permeability of the ion channels to sodium, which in turn, diminishes the rate of depolarization. These agents (a.k.a. -caines) are also used to depress mucosal sensations, e.g., gag reflex in the form of topical anesthetics. Overdose of LA can lead to local anesthetic systemic toxicity (LAST), which is the precursor of potentially lethal consequences on clinical grounds. There is a wide array of possible presentations of LAST, from mild findings, such as temporary hypertensive events, to serious conditions, including refractory cardiac dysfunction, dysrhythmias and prearrest situations...
May 25, 2023: Current Pharmaceutical Design
https://read.qxmd.com/read/37180689/comparison-of-the-success-of-inferior-alveolar-nerve-anesthesia-in-the-mandibular-first-molars-with-symptomatic-irreversible-pulpitis-using-two-anesthetic-solutions-of-prilocaine-and-mepivacaine-a-randomized-controlled-clinical-trial
#30
JOURNAL ARTICLE
Mahsa Eskandarinezhad, Negin Ghasemi, Parisa Rostami, Amir Ardalan Abdollahi
BACKGROUND: This study aimed to compare the success rate of inferior alveolar nerve (IAN) anesthesia in the mandibular first molars with symptomatic irreversible pulpitis using two anesthetic solutions of prilocaine and mepivacaine. MATERIALS AND METHODS: The current randomized controlled clinical trial was conducted on 100 patients in two groups ( n = 50). Standard injection of IAN block (IANB) was performed using two cartridges of 3% mepivacaine plain in the first group and using two cartridges of 3% prilocaine with 0...
2023: Dental Research Journal
https://read.qxmd.com/read/37119368/safety-and-utility-of-ultrasound-guided-superior-cervical-ganglion-block-for-headaches-and-orofacial-pain-a-retrospective-single-center-study-of-10-patients
#31
JOURNAL ARTICLE
Aiko Maeda, Yoji Chikama, Ryudo Tanaka, Masachika Tominaga, Kazuhiro Shirozu, Ken Yamaura
BACKGROUND: Several new ultrasound-guided superior cervical ganglia blocks (U-SCGBs) have been proposed to overcome the shortcomings of conventional superior cervical ganglia blocks; however, their clinical utility and practicality have not yet been demonstrated. The aim of this study was to evaluate the safety and utility of a new method of U-SCGB. METHODS: We retrospectively collected data on patients who underwent U-SCGB for the treatment of headaches and orofacial pain at a single center...
April 29, 2023: JA Clinical Reports
https://read.qxmd.com/read/37078000/microrna-27a-suppresses-the-toxic-action-of-mepivacaine-on-breast-cancer-cells-via-inositol-requiring-enzyme-1-tnf-receptor-associated-factor-2
#32
JOURNAL ARTICLE
WenHong Fu, XiaoLing Hu, GengZhang Li, SongTao Liu
OBJECTIVE: To investigate the toxic effects of microRNA-27a on breast cancer cells through inositol-acquiring enzyme 1-TNF receptor-associated factor 2 inhibition by mepivacaine. METHODS: The elevation of miR-27a in MCF-7 of BCC lines was measured, and groups were set up as control, mepivacaine, and elevated groups. Cells from each group were examined for inflammatory progression. RESULTS: Elevated miR-27a in MCF-7 cells was able to distinctly augment the cell advancement ( P < 0...
2023: Contrast Media & Molecular Imaging
https://read.qxmd.com/read/36988627/comprehensive-analysis-of-local-anesthetics-affecting-adipose-stem-cells-in-vitro
#33
JOURNAL ARTICLE
Vincent G J Guillaume, Ella F Lippold, Justus P Beier, Tim Ruhl
BACKGROUND: Fat grafting represe nts a common technique to treat volume deficits, e.g. for breast augmentation. Therein, adipose stem cells (ASCs) hold a great regenerative capacity, because of their differentiation capability and, more importantly, their secretory activity. Thus, the survival of ASCs is of great significance during perioperative harvesting. Various local anesthetics are commonly applied during fat grafting procedures. Historically, these substances are known to impair cellular viability, which would affect graft survival and its final outcome...
March 27, 2023: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/36961318/pain-management-following-dental-trauma-and-surgical-procedures
#34
REVIEW
Stanley F Malamed
Surgical procedures and post-traumatic management of dental patients require effective pain management during treatment, but being considerably more invasive than conservative treatments, pain management is required into the postoperative period. Clinical trials on pain intensity following dental surgical procedures (e.g., 3rd molar extraction, implant placement, periodontal, and endodontic surgery) have shown that pain is most intense approximately 5-6 h after completion of the procedure, reaching its peak levels during the first postoperative day...
March 24, 2023: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://read.qxmd.com/read/36958714/spinal-anesthesia-for-primary-hip-and-knee-arthroplasty-comparative-rates-of-transient-neurological-symptoms-and-urinary-retention-using-lidocaine-mepivacaine-and-bupivacaine
#35
JOURNAL ARTICLE
Sean E Slaven, Emin S Dedeogullari, Nancy L Parks, Robert A Sershon, Kevin B Fricka, William G Hamilton
BACKGROUND: Short-acting spinal anesthetics enable rapid recovery after hip and knee arthroplasty; however, concerns with transient neurological symptoms (TNS) cause some to avoid using lidocaine. Postoperative urinary retention (POUR) is also a concern with spinal anesthesia. We sought to study the comparative rates of TNS and POUR between lidocaine, mepivacaine, and bupivacaine in a high-volume hip and knee arthroplasty setting. METHODS: Data for 1,217 primary THA, TKA, and unicompartmental knee arthroplasty cases were reviewed and grouped by spinal anesthetic agent (lidocaine, mepivacaine, or bupivacaine)...
June 2023: Journal of Arthroplasty
https://read.qxmd.com/read/36928300/crystallization-of-short-acting-and-intermediate-acting-local-anesthetics-when-mixed-with-adjuvants-a-semiquantitative-light-microscopy-analysis
#36
JOURNAL ARTICLE
Elisabeth Hoerner, Ottokar Stundner, Heidi Fiegl, Lukas Gasteiger
INTRODUCTION: The addition of adjuvants to short-acting local anesthetics (LA) is common practice in clinical routine to speed up block onset and decrease pain on injection. In a previous study, we observed the development of microscopic crystal precipitations after bupivacaine or ropivacaine were mixed with adjuvants; this follow-up study is intended to clarify whether crystallization (A) also occurs in short-acting or intermediate-acting LA-adjuvant mixtures, (B) changes over time, and (C) is associated with the solutions' pH...
October 2023: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/36921025/intrathecal-mepivacaine-after-general-anesthesia-is-an-effective-method-of-equine-euthanasia-when-compared-to-intravenous-pentobarbital
#37
JOURNAL ARTICLE
Kate Alexander, Embry Simon, Khursheed Mama, Sangeeta Rao, Luke Bass
OBJECTIVES: This study aims to assess intrathecal mepivacaine for euthanasia in anesthetized horses and compare it to a traditional euthanasia method using a single intravenous injection of pentobarbital in sedated horses. ANIMALS: Client-owned horses and horses requiring euthanasia due to involvement in concurrent research projects were used. Horses were randomly assigned to 1 of 2 groups: intrathecal mepivacaine after anesthesia or intravenous pentobarbital after sedation...
March 19, 2023: American Journal of Veterinary Research
https://read.qxmd.com/read/36847742/comparative-study-of-the-anaesthetic-efficacy-of-4-articaine-versus-2-mepivacaine-in-mandibular-third-molar-germectomy-using-different-anaesthetic-techniques-a-split-mouth-clinical-trial
#38
JOURNAL ARTICLE
Dardo Menditti, Mariarosaria Boccellino, Ludovica Nucci, Antonino P Ribeiro Sobrinho, Andrea Marotta, Pasquale Angrisani, Stefania Cantore, Marco Menditti, Antonio Vitiello, Marina DI Domenico, Barbara Rinaldi, Alfredo DE Rosa
BACKGROUND: Currently, one of the most discouraging aspects for many patients undergoing dental procedures is the administration of local anaesthesia. Therefore, there is a constant search for new techniques to avoid the invasive and painful nature of the injection. This study aimed to compare the clinical efficacy of local anaesthetics with articaine 4% or mepivacaine 2% (both with epinephrine 1:100.000), using different anaesthetic techniques to perform germectomy of lower third molars and to assess patients' feelings and pain during surgery...
February 2023: Minerva dental and oral science
https://read.qxmd.com/read/36821081/changes-in-neuraxial-anesthesia-protocols-and-improved-efficiency-of-same-day-discharge-total-knee-arthroplasty-in-an-ambulatory-surgery-center-a-retrospective-cohort-study
#39
JOURNAL ARTICLE
Tyler E Calkins, Clayton C Wing, Zachary R Diltz, William M Mihalko, Patrick C Toy
INTRODUCTION: This study evaluated the effect of bupivacaine versus mepivacaine spinal anesthesia and preoperative adductor canal block (ACB) on recovery, length of stay, pain, and complications of same-day discharge total knee arthroplasty (TKA) at a free-standing ambulatory surgery center. METHODS: We performed a retrospective review of patients who underwent TKA between March 2018 and September 2019. The patients were grouped based on the neuraxial anesthetic regimen: bupivacaine with ACB, bupivacaine without ACB, and mepivacaine without ACB...
March 1, 2023: Journal of the American Academy of Orthopaedic Surgeons
https://read.qxmd.com/read/36798042/treatment-efficacy-of-0-9-saline-and-mepivacaine-infiltration-with-dermojet%C3%A2-in-eliminating-plantar-warts
#40
JOURNAL ARTICLE
Oltra-Romero Ana M, Garcia-Lázaro Silvia, Gracia-Sánchez Alba, Zúnica-García Sara, Chicharro-Luna Esther
BACKGROUND: Plantar warts are benign, epidermal neoformations, viral, and easily transmitted. Although 30% of these warts disappear spontaneously, the American Association of Dermatology recommends treatment if they cause pain or bleeding. OBJECTIVES: The aim of this study was to determine the efficacy of Dermojet® infiltration using a solution composed of equal parts of 0.9% saline and 2% mepivacaine in the treatment of plantar warts, and to identify the type of necrosis achieved at 7-10 days after the infiltration (M1 sample) and at 15-17 days (M2 sample)...
July 2023: Journal of Cosmetic Dermatology
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