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Mepivacain

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https://www.readbyqxmd.com/read/28514354/-out-patient-dental-care-in-patients-with-arterial-hypertension
#1
L A Axamit, E N Anisimova, I V Orekhova, S T Sokhov
The aim of the study was to improve dental treatment quality in patients with arterial hypertension. The study included 256 patients with arterial hypertension (153 females, 103 males) aged 35 to 60 years. Anesthesia efficacy was assessed by visual analog scale after treatment. Oral adverse effects caused by regular intake of antihypertensive drugs and interrelation with articaine and mepivacaine were described. The study proved high efficacy of 4% articaine 1:200 000. The efficacy of 3% mepivacaine with no vasoconstriction agents was 86...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28491114/optimal-solubility-of-diclofenac-%C3%AE-cyclodextrin-in-combination-with-local-anaesthetics-for-mesotherapy-applications
#2
Giuseppe Tringali, Pierluigi Navarra
Because of low injection volume, the recently marketed injectable solution of diclofenac in complex with β-cyclodextrin (Akis®, IBSA Farmaceutici Italia) is an ideal candidate for mesotherapy applications. In this study, we investigated the solubility of Akis, 25 and 50 mg/kg, in combination with various local anaesthetics (lidocaine, mepivacaine, bupivacaine, levobupivacaine, and ropivacaine) at different concentrations in aqueous vehicles (normal saline, sterile water, or bicarbonate). Final injection mixtures were classified as limpid, turbid, or milky at visual analysis under standardized conditions...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28489457/adverse-events-associated-with-a-large-dose-of-intravenous-lipid-emulsion-for-suspected-local-anesthetic-toxicity
#3
Daniel J Corwin, Alexis Topjian, Brenda L Banwell, Kevin Osterhoudt
BACKGROUND: Intravenous lipid emulsion (ILE) has gained favor as a rescue treatment for cardiovascular collapse due to intravenous local anesthetic overdose, however, goals of ILE therapy are still being defined. We describe a case of a girl given 66 mL/kg of 20% lipid emulsion (ILE) in the treatment of presumed mepivacaine toxicity. CASE REPORT: An 11-year-old girl weighing 55.6 kg developed pallor, rolling back of the eyes, and rhythmic muscle twitching after receiving a mandibular nerve block injection with a 1...
July 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28460873/long-term-therapeutic-effects-of-dextrose-prolotherapy-in-patients-with-hypermobility-of-the-temporomandibular-joint-a-single-arm-study-with-1-4-years-follow-up
#4
H Refai
The aim was to analyse the short-term and long-term therapeutic efficacy of dextrose prolotherapy for dislocation or subluxation (hypermobility) of the temporomandibular joint (TMJ). Sixty-one patients with symptomatic hypermobility of the TMJ were included in this single-arm prospective study, in which they were each given four sessions of intra-articular and pericapsular injections six weeks apart. Each injection comprised 10% dextrose/mepivacaine solution 3ml. Clinical outcomes including severity of pain on movement according to the numerical rating scale (NRS), maximal interincisal opening, clicking, and frequency of locking were measured before treatment (T1), during treatment (T2) (just before the third session of injections), at the short-term follow-up (T3) (three months after treatment), and at the long-term follow-up (T4) (1-4 years after treatment)...
April 28, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28442952/comparison-of-onset-anesthesia-time-and-injection-discomfort-of-4-articaine-and-2-mepivacaine-during-teeth-extractions
#5
Giath Gazal, Rashdan Alharbi, Wamiq Musheer Fareed, Esam Omar, Albraa Badr Alolayan, Hassan Al-Zoubi, Ahmad A Alnazzawi
OBJECTIVE: To investigate the speed of action and injection discomfort of 4% articaine and 2% mepivacaine for upper teeth extractions. MATERIALS AND METHODS: Forty-five patients were included in the articaine 4% group, and 45 in the mepivacaine 2% control group. After all injections, soft and hard tissue numbness was objectively gauged by dental probe at intervals of 15 s. Furthermore, the discomfort of the injections were recorded by the patients after each treatment on standard 100 mm visual analog scales, tagged at the endpoints with "no pain" (0 mm) and "unbearable pain" (100 mm)...
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28408851/prilocaine-hydrochloride-2-hyperbaric-solution-for-intrathecal-injection-a-clinical-review
#6
REVIEW
Alberto Manassero, Andrea Fanelli
Prilocaine is a local anesthetic characterized by intermediate potency and duration and fast onset of action. As hyperbaric formulation of 5% solution, it was introduced and has been successfully used for spinal anesthesia since 1960. A new formulation of 2% plain and hyperbaric solution is currently available in Europe. Because of its lower incidence of transient neurological symptoms, prilocaine is suggested as substitute to lidocaine and mepivacaine in spinal anesthesia for ambulatory surgery, as well as a suitable alternative to low doses of long-acting local anesthetics...
2017: Local and Regional Anesthesia
https://www.readbyqxmd.com/read/28403602/nonabsorbable-polymer-clip-as-a-cause-of-chronic-perineal-pain-after-radical-prostatectomy-description-of-a-case-treated-by-transperineal-approach
#7
Massimiliano Creta, Sergio Di Meo, Roberto Buonopane, Bernardo Rocco, Vittorio Imperatore
The occurrence of persistent perineal pain caused by surgical clips has rarely been described after radical prostatectomy (RP). We describe the case of a patient complaining of chronic perineal pain occurred soon after robotic RP, refractory to conventional medical therapy and exacerbated by the sitting position. Pain was related to a nonabsorbable polymer clip used to secure lateral pedicles. A transpeerineal approach was used to perform an hydrodissection of the rectovesical space at the level of the surgical clip combined with local injection of mepivacaine and betametasone...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28330526/different-spectrophotometric-and-chromatographic-methods-for-determination-of-mepivacaine-and-its-toxic-impurity
#8
Nada S Abdelwahab, Nehal F Fared, Mohamed Elagawany, Esraa H Abdelmomen
Stability-indicating spectrophotometric, TLC-densitometric, and ultra-performance LC (UPLC) methods were developed forthe determination of mepivacaine HCl (MEP) in the presence of its toxic impurity, 2,6-dimethylanaline (DMA). Different spectrophotometric methods were developed for the determination of MEP and DMA. In a dual-wavelength method combined with direct spectrophotometric measurement, the absorbance difference between 221.4 and 240 nm was used for MEP measurements, whereas the absorbance at 283 nm was used for measuring DMA in the binary mixture...
February 21, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28319552/evaluation-of-lung-function-and-clinical-features-of-the-ultrasound-guided-stellate-ganglion-block-with-2-different-concentrations-of-a-local-anesthetic-a-randomized-controlled-trial
#9
Won-Joong Kim, Hahck Soo Park, Myung Sub Yi, Gill-Hoi Koo, Hwa-Yong Shin
BACKGROUND: One possible complication of stellate ganglion block (SGB) is respiratory compromise. No study has yet addressed the comparison of its effect on lung function and clinical features, including Horner's syndrome, changes in temperature, sensory and motor functions, and adverse events of lower versus higher concentrations (LC and HC, respectively) of local anesthetics in an ultrasound-guided SGB. METHODS: Fifty patients were randomized into 1 of 2 groups: the LC group (5 mL of 0...
April 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28289821/single-dose-local-anesthetics-exhibit-a-type-dose-and-time-dependent-chondrotoxic-effect-on-chondrocytes-and-cartilage-a-systematic-review-of-the-current-literature
#10
REVIEW
Peter Cornelius Kreuz, Matthias Steinwachs, Peter Angele
PURPOSE: Many studies have shown that local anesthetics may impede chondrocyte metabolism. However, the influence of a single-dose local anesthetics is controversial. The aim of this metaanalysis was to review the literature for studies investigating the cytotoxic effects of single-dose local anesthetics on chondrocytes and cartilage. METHODS: A comprehensive literature search was performed using established search engines (Medline, Embase) to identify studies, investigating the influence of single-dose local anesthetics on cartilage...
March 13, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28277420/regional-to-the-rescue-axillary-brachial-plexus-nerve-block-facilitates-removal-of-entrapped-transradial-catheter-placed-for-cardiac-catheterization
#11
Brian M Fitzgerald, Lee A Babbel, Ferdinand K Bacomo, Sandeep T Dhanjal
OBJECTIVE: Our objective was to describe the first reported use of an axillary brachial plexus block to treat the entrapment of a transradial artery catheter due to vasospasm. CASE REPORT: A 42-year-old man undergoing transradial arterial cardiac catheterization suffered arterial vasospasm causing the catheter to become entrapped and refractory to conservative (warm compresses) and standard pharmacologic interventions (intracatheter verapamil, intravenous infusions of nitroglycerin and nicardipine, and subcutaneous lidocaine and topical nitroglycerin)...
March 8, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28271334/topical-treatments-for-localized-neuropathic-pain
#12
REVIEW
Roberto Casale, Z Symeonidou, M Bartolo
PURPOSE OF REVIEW: Topical therapeutic approaches in localized neuropathic pain (LNP) syndromes are increasingly used by both specialists and general practitioners, with a potentially promising effect on pain reduction. In this narrative review, we describe the available compounds for topical use in LNP syndromes and address their potential efficacy according to the literature. RECENT FINDINGS: Local anaesthetics (e.g., lidocaine, bupivacaine and mepivacaine), as well as general anaesthetic agents (e...
March 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28235506/effective-volumes-of-1-5-mepivacaine-with-different-sodium-concentration-for-ultrasound-guided-popliteal-block
#13
Mercedes López, Miguel Calvo, Azahara Sancho, Nicolas Brogly, Emilia Guasch, Fernando Gilsanz
STUDY OBJECTIVE: To determine if a solution of 1.5% mepivacaine diluted with 5% dextrose, which decreases the sodium concentration by 30%, results in reduced volume requirements for a complete sensory block, in the case of an ultrasound guided popliteal nerve block. DESIGN: A randomized controlled study. SETTING: Operating room. PATIENTS: We included seventy ASA 1-3 patients, undergoing unilateral "hallux valgus" repair under ultrasound guided popliteal nerve block...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28215443/2-mepivacaine-seems-to-do-better-than-2-%C3%A2-lidocaine-in-achieving-successful-anesthesia-in-posterior-teeth-with-irreversible-pulpitis
#14
Romina Brignardello-Petersen
No abstract text is available yet for this article.
February 16, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28120017/-sciatic-nerve-block-out-of-plane-distal-to-the-bifurcation-effective-and-safe
#15
RANDOMIZED CONTROLLED TRIAL
T Geiser, J Apel, O Vicent, J Büttner
BACKGROUND: Ultrasound guided distal sciatic nerve block (DSB) at bifurcation level shows fast onset and provides excellent success rates. However, its safe performance might be difficult for the unexperienced physician. Just slightly distal to the bifurcation, the tibial nerve (TN) and common fibular nerve (CFN) can be shown clearly separated from each other. Therefore, we investigated if a block done here would provide similar quality results compared to the DSB proximally to the division, with a potentially lower risk of nerve damage...
March 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28017345/axillary-brachial-plexus-block-duration-with-mepivacaine-in-patients-with-chronic-renal-failure-case-control-study
#16
V Mojica, D Nieuwveld, A E Herrera, G Mestres, A M López, X Sala-Blanch
INTRODUCTION: Regional anaesthesia is commonly preferred for arteriovenous fistula (AVF) creation. Previous studies suggest a shorter block duration in patients with chronic renal failure, maybe because of the changes in regional blood flow. The aim of our study was to evaluate the duration of the axillary block with 1.5% mepivacaine in patients with chronic renal failure scheduled for AVF compared with healthy controls. METHODS: Patients scheduled for AVF creation for the first time (GIRC) were included...
April 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28004094/chemiluminescence-determination-of-local-anaesthetic-mepivacaine-in-human-plasma-and-pharmaceuticals
#17
Ali Mokhtari
In this study, a new method has been developed for the simple determination of mepivacaine (carbocaine). The method is based on the enhancement effect of mepivacaine in the chemiluminescence (CL) reaction of tris(1,10 phenanthroline) ruthenium(II) with cerium(IV). A mechanism for the CL reaction has been proposed on the basis of UV-Vis, fluorescent and CL spectra. Under optimum conditions, the CL intensity was proportional to the concentration of the drug in solution over the range 0.45-226.25 μg mL-1 (R2 = 0...
December 2016: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/27976931/a-novel-lc-ms-ms-method-for-mepivacaine-determination-and-pharmacokinetic-study-in-a-single-dose-two-period-crossover-in-healthy-subjects
#18
Ruo-Wang Duan, Jiong Song, Yu-Ping Li, Chun-Gen Xing
The objective of this work was to develop a simple, selective, and sensitive LC-MS/MS method for the quantitation of the mepivacaine in Chinese biological matrix. The calibration curve of mepivacaine ranged from 0.5 to 2000 ng/mL with the lower limit of quantitation being 0.5 ng/mL. This sensitivity was high enough to describe the profile of blood mepivacaine level versus time. Thereby it was very desirable for the pharmacokinetic study because of its high sensitivity and accuracy. The study used a single-dose two-period crossover design principle...
December 15, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/27938934/medial-approach-of-ultrasound-guided-costoclavicular-plexus-block-and-its-effects-on-regional-perfussion
#19
D Nieuwveld, V Mojica, A E Herrera, J Pomés, A Prats, X Sala-Blanch
INTRODUCTION: Ultrasound-guided infraclavicular block in the costoclavicular space located between the clavicle and the first rib, reaches the secondary trunks when they are clustered together and lateral to the axillary artery. This block is most often performed through a lateral approach, the difficulty being finding the coracoid process an obstacle and guiding the needle towards the vessels and pleura. A medial approach, meaning from inside to outside, will avoid these structures. Traditionally the assessment of a successful block is through motor or sensitive responses but a sympathetic fibre block can also be evaluated measuring the changes in humeral artery blood flow, skin temperature and/or perfusion index...
April 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/27938712/the-stability-and-microbial-contamination-of-bupivacaine-lidocaine-and-mepivacaine-used-for-lameness-diagnostics-in-horses
#20
D M T Adler, C Cornett, P Damborg, D R Verwilghen
Local anaesthetics (LAs) are frequently used for diagnostic procedures in equine veterinary practice. The objective of this study was to investigate the physico-chemical stability and bacterial contamination of bupivacaine, lidocaine and mepivacaine used for lameness examinations in horses. The LAs were stored in 12 different groups at different temperatures (-18 °C to 70 °C), light intensities and in common veterinary field conditions for up to 16 months. The pH, presence of bacterial contamination and concentrations of LAs and methylparaben (a preservative present in lidocaine) were determined serially in both new and repeatedly punctured (RP) vials...
December 2016: Veterinary Journal
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