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Mepivacain

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https://www.readbyqxmd.com/read/29199070/anaesthetic-efficacy-of-4-articaine-compared-with-2-mepivacaine-a-randomized-double-blind-crossover-clinical-trial
#1
M C Bortoluzzi, P de Camargo Smolarek, R Cecato, M T Pochapski, A C R Chibinski
The aim of this study was to evaluate the clinical efficacy of 4% articaine (Ar4) compared to 2% mepivacaine (Me2), both in combination with 1:100,000 epinephrine, in a unique soft tissue model. This was a randomized, double-blind, crossover clinical trial. The anaesthetic was applied to the lower lip using a computerized local delivery system. The following were evaluated: blood flow, thermal sensation, pressure and proprioception, extent of anaesthesia, gradual elimination, and the final duration of the effect of the anaesthesia...
November 30, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29115971/local-anaesthetics-or-their-combination-with-morphine-and-or-magnesium-sulphate-are-toxic-for-equine-chondrocytes-and-synoviocytes-in-vitro
#2
L M Rubio-Martínez, E Rioja, M Castro Martins, S Wipawee, P Clegg, M J Peffers
BACKGROUND: Chondrotoxic effects of local anaesthetics are well reported in humans and some animal species but knowledge on their toxic effects on synoviocytes or equine chondrocytes or the effects on cellular production of inflammatory cytokines is limited. The purpose of this study was to evaluate the in vitro effects of local anaesthetics, morphine, magnesium sulphate (MgSO4) or their combinations on cell viability and pro-inflammatory cytokine gene expression of equine synoviocytes and chondrocytes...
November 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29049072/effect-of-stellate-ganglion-block-on-the-regional-hemodynamics-of-the-upper-extremity-a-randomized-controlled-trial
#3
Min Kyoung Kim, Myung Sub Yi, Pyung Gul Park, Hyun Kang, Jae Sung Lee, Hwa Yong Shin
BACKGROUND: The success of stellate ganglion block (SGB) is traditionally determined on the basis of findings such as Horner's syndrome, temperature rise in the face, hyperemia of the tympanic membrane, and nasal congestion. However, decreases in vascular resistance and increases in blood flow in the arm may be more meaningful findings. To date, the effect of SGB on the regional hemodynamics of the arm has not been evaluated using pulsed-wave Doppler ultrasound. METHODS: A total of 52 patients who were to undergo orthopedic surgery of the forearm were randomly assigned to either the mepivacaine group (SGB with 5 mL of 0...
October 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29046780/myoclonus-of-ipsilateral-upper-extremity-after-ultrasound-guided-supraclavicular-brachial-plexus-block-with-mepivacaine
#4
Bong Jin Kang, Jaegyok Song, Sung-Mi Ji, Jong Pil Kim
No abstract text is available yet for this article.
October 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28871844/management-of-bleeding-in-exclusive-endoscopic-ear-surgery-pilot-clinical-experience
#5
Lukas Anschuetz, Marco Bonali, Pierre Guarino, Filippo B Fabbri, Matteo Alicandri-Ciufelli, Domenico Villari, Marco Caversaccio, Livio Presutti
Objective Transcanal exclusive endoscopic ear surgery requires the management of the endoscope and the surgical instruments in the external auditory canal. Bleeding in this narrow space is one of the most challenging issues, especially for novice endoscopic ear surgeons. We aim to assess the severity and occurrence of bleeding and describe strategies to control the bleeding during endoscopic ear surgery. We hypothesize that bleeding is reasonably controllable in endoscopic ear surgery. Study Design Case series with chart review...
October 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28806384/transient-amaurosis-and-diplopia-after-inferior-alveolar-nerve-block
#6
Onur Odabaşi, Onur Şahin, Mehmet Emrah Polat
A 40-year-old female patient was admitted to the authors' oral and maxillofacial clinic for removal of her lower left second molar under local anesthesia. The patient's medical history revealed that she had cardiac arhythmia and hypertension. Inferior alveolar nerve block was achieved using 2 mL of sefacaine (%3 mepivacaine HCL, without epinephrine). The patient complained of loss of vision in her left eye. All procedures were stopped immediately. Within 2 minutes the patient reported diplopia. All of the symptoms disappeared about 5 minutes after initial observation...
October 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28803906/viscosupplementation-for-hip-osteoarthritis-a-systematic-review-and-meta-analysis-of-the-efficacy-for-pain-disability-and-adverse-events
#7
REVIEW
Victor Figueiredo Leite, João Eduardo Daud Amadera, Anna Maria Buehler
OBJECTIVE: To assess the efficacy of viscosupplementation (HA) in hip osteoarthritis (OA) pain, disability and adverse events. DATA SOURCES: Pubmed, EMBASE, Cochrane Library, ClinicalTrials.gov database and specific journals up to March 2017. STUDY SELECTION: Randomized controlled trials comparing HA with any other intra-articular injection. DATA EXTRACTION: Performed according to Cochrane/GRADE criteria. Two authors extracted data, assessed risk of bias and quality of evidence...
August 10, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28760404/retinal-toxicity-after-accidental-intravitreal-injection-of-mepivacaine-and-adrenaline
#8
F López-Herrero, J L Sánchez-Vicente, J Monge-Esquivel, E Parra-Oviedo, A Martínez-Borrego, A Muñoz-Morales
CASE REPORT: The case is presented of a 32 year-old male with no medical history of interest who suffered a traffic accident with mild traumatic brain injury. He had a left supraciliary incised and contused wound that extended to the left upper eyelid, with no loss of vision. After palpebral anaesthetic injection, there was a sudden visual acuity decrease in the left eye and hyposphagma located between I-III at 4mm from the limbus, with increased intraocular pressure. A whitish lesion with a central haemorrhagic focus was observed in the ocular fundus, corresponding to the area where the hyposphagma was located...
July 28, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28714266/potential-biotechnological-capabilities-of-cultivable-mycobiota-from-carwash-effluents
#9
Timothy Sibanda, Ramganesh Selvarajan, Memory Tekere, Hlengilizwe Nyoni, Stephen Meddows-Taylor
Urban life has created man-made extreme environments like carwashes. These environments have, however, not been sufficiently explored for mycobiota that can be sources of biotechnologically useful products, as has been the case with natural extreme environments. Using a combination of culture and molecular techniques, fungi from carwash effluents was characterized for production of lipase and cellulase enzymes, nonpolar and polar biotechnologically relevant secondary metabolites and hydrocarbon utilization...
October 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28703891/duration-of-action-of-mepivacaine-and-lidocaine-in-equine-palmar-digital-perineural-blocks-in-an-experimental-lameness-model
#10
Mona Hoerdemann, Rachael L Smith, Giselle Hosgood
OBJECTIVE: To establish and compare the onset and duration of action of 2 local anesthetics based on objective lameness and skin sensitivity assessment. STUDY DESIGN: Interventional crossover experimental trial with balanced randomization. ANIMALS: Eight horses. METHODS: Reversible forelimb lameness was induced in 8 horses. A palmar digital nerve block (PDNB) was applied with mepivacaine or lidocaine (both 2%). Quantitative lameness and skin sensitivity data were collected with an inertial sensor system and a force gauge, respectively...
July 13, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28694714/sensitivity-specificity-predictive-values-and-accuracy-of-three-diagnostic-tests-to-predict-inferior-alveolar-nerve-blockade-failure-in-symptomatic-irreversible-pulpitis
#11
Daniel Chavarría-Bolaños, Laura Rodríguez-Wong, Danny Noguera-González, Vicente Esparza-Villalpando, Mauricio Montero-Aguilar, Amaury Pozos-Guillén
INTRODUCTION: The inferior alveolar nerve block (IANB) is the most common anesthetic technique used on mandibular teeth during root canal treatment. Its success in the presence of preoperative inflammation is still controversial. The aim of this study was to evaluate the sensitivity, specificity, predictive values, and accuracy of three diagnostic tests used to predict IANB failure in symptomatic irreversible pulpitis (SIP). METHODOLOGY: A cross-sectional study was carried out on the mandibular molars of 53 patients with SIP...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28671067/the-antimicrobial-activity-of-bupivacaine-lidocaine-and-mepivacaine-against-equine-pathogens-an-investigation-of-40-bacterial-isolates
#12
D M T Adler, P Damborg, D R Verwilghen
Lameness is the most commonly reported health problem in horses, and lameness investigations which include local anaesthetic injections are routinely performed by equine practitioners. Through this process, bacteria can enter the tissues perforated by the needle and may cause local infections at the injection site. The objective of this in vitro study was to investigate if local anaesthetics at concentrations available in commercially available solutions could inhibit growth and/or kill bacteria that could be inoculated into the synovial space or soft tissues during injection...
May 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28550902/quantification-of-the-vasodilatory-effect-of-axillary-plexus-block-a-prospective-controlled-study
#13
Andrea Wenger, Jens Rothenberger, Lara-Elena Hakim-Meibodi, Thomas Notheisen, Hans-Eberhard Schaller
BACKGROUND: Axillary plexus block is a common method for regional anesthesia, especially in hand and wrist surgery. Local anesthetics (e.g., mepivacaine) are injected around the peripheral nerves in the axilla. A vasodilatory effect due to sympathicolysis has been described, but not quantified. MATERIALS AND METHODS: In a prospective controlled study between October 2012 and July 2013, we analyzed 20 patients with saddle joint arthritis undergoing trapeziectomy under axillary plexus block...
May 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28549932/2-adamantanamine-produces-prolonged-spinal-block-in-rats
#14
Yu-Wen Chen, Chia-Ming Chen, Kuo-Sheng Liu, Jhi-Joung Wang, Ching-Hsia Hung
We aimed to investigate the local anesthetic effect of 2-adamantanamine in spinal anesthesia. The dose-response curves were constructed after intrathecally injecting the rats with five doses of 2-adamantanamine and a common local anesthetic mepivacaine. The quality and duration of 2-adamantanamine at producing spinal nociceptive, proprioceptive and motor block were compared with that of mepivacaine. We revealed that 2-adamantanamine provoked spinal nociceptive, proprioceptive and motor block dose-dependently...
July 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28546014/-anesthetic-requirements-measured-by-bilateral-bispectral-analysis-and-femoral-blockade-in-total-knee-arthroplasty
#15
Maylin Koo, Javier Bocos, Antoni Sabaté, Vinyet López, Carmina Ribes
BACKGROUND AND OBJECTIVES: A continuous peripheral nerve blockade has proved benefits on reducing postoperative morphine consumption; the combination of a femoral blockade and general anesthesia on reducing intraoperative anesthetic requirements has not been studied. The objective of this study was to determine the relevance of timing in the performance of femoral block to intraoperative anesthetic requirements during general anesthesia for total knee arthroplasty. METHODS: A single-center, prospective cohort study on patients scheduled for total knee arthroplasty, were sequentially allocated to receive 20mL of 2% mepivacaine throughout a femoral catheter, prior to anesthesia induction (Preoperative) or when skin closure started (Postoperative)...
May 22, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28514354/-out-patient-dental-care-in-patients-with-arterial-hypertension
#16
L A Axamit, E N Anisimova, I V Orekhova, S T Sokhov
The aim of the study was to improve dental treatment quality in patients with arterial hypertension. The study included 256 patients with arterial hypertension (153 females, 103 males) aged 35 to 60 years. Anesthesia efficacy was assessed by visual analog scale after treatment. Oral adverse effects caused by regular intake of antihypertensive drugs and interrelation with articaine and mepivacaine were described. The study proved high efficacy of 4% articaine 1:200 000. The efficacy of 3% mepivacaine with no vasoconstriction agents was 86...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28491114/optimal-solubility-of-diclofenac-%C3%AE-cyclodextrin-in-combination-with-local-anaesthetics-for-mesotherapy-applications
#17
Giuseppe Tringali, Pierluigi Navarra
Because of low injection volume, the recently marketed injectable solution of diclofenac in complex with β-cyclodextrin (Akis®, IBSA Farmaceutici Italia) is an ideal candidate for mesotherapy applications. In this study, we investigated the solubility of Akis, 25 and 50 mg/kg, in combination with various local anaesthetics (lidocaine, mepivacaine, bupivacaine, levobupivacaine, and ropivacaine) at different concentrations in aqueous vehicles (normal saline, sterile water, or bicarbonate). Final injection mixtures were classified as limpid, turbid, or milky at visual analysis under standardized conditions...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28489457/adverse-events-associated-with-a-large-dose-of-intravenous-lipid-emulsion-for-suspected-local-anesthetic-toxicity
#18
Daniel J Corwin, Alexis Topjian, Brenda L Banwell, Kevin Osterhoudt
BACKGROUND: Intravenous lipid emulsion (ILE) has gained favor as a rescue treatment for cardiovascular collapse due to intravenous local anesthetic overdose, however, goals of ILE therapy are still being defined. We describe a case of a girl given 66 mL/kg of 20% lipid emulsion (ILE) in the treatment of presumed mepivacaine toxicity. CASE REPORT: An 11-year-old girl weighing 55.6 kg developed pallor, rolling back of the eyes, and rhythmic muscle twitching after receiving a mandibular nerve block injection with a 1...
July 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28460873/long-term-therapeutic-effects-of-dextrose-prolotherapy-in-patients-with-hypermobility-of-the-temporomandibular-joint-a-single-arm-study-with-1-4-years-follow-up
#19
H Refai
The aim was to analyse the short-term and long-term therapeutic efficacy of dextrose prolotherapy for dislocation or subluxation (hypermobility) of the temporomandibular joint (TMJ). Sixty-one patients with symptomatic hypermobility of the TMJ were included in this single-arm prospective study, in which they were each given four sessions of intra-articular and pericapsular injections six weeks apart. Each injection comprised 10% dextrose/mepivacaine solution 3ml. Clinical outcomes including severity of pain on movement according to the numerical rating scale (NRS), maximal interincisal opening, clicking, and frequency of locking were measured before treatment (T1), during treatment (T2) (just before the third session of injections), at the short-term follow-up (T3) (three months after treatment), and at the long-term follow-up (T4) (1-4 years after treatment)...
June 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28442952/comparison-of-onset-anesthesia-time-and-injection-discomfort-of-4-articaine-and-2-mepivacaine-during-teeth-extractions
#20
Giath Gazal, Rashdan Alharbi, Wamiq Musheer Fareed, Esam Omar, Albraa Badr Alolayan, Hassan Al-Zoubi, Ahmad A Alnazzawi
OBJECTIVE: To investigate the speed of action and injection discomfort of 4% articaine and 2% mepivacaine for upper teeth extractions. MATERIALS AND METHODS: Forty-five patients were included in the articaine 4% group, and 45 in the mepivacaine 2% control group. After all injections, soft and hard tissue numbness was objectively gauged by dental probe at intervals of 15 s. Furthermore, the discomfort of the injections were recorded by the patients after each treatment on standard 100 mm visual analog scales, tagged at the endpoints with "no pain" (0 mm) and "unbearable pain" (100 mm)...
April 2017: Saudi Journal of Anaesthesia
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