keyword
https://read.qxmd.com/read/38443138/crystallization-of-mixtures-of-local-anesthetics-with-and-without-select-adjuvants-a-semiquantitative-light-microscopy-analysis
#1
JOURNAL ARTICLE
Elisabeth Hoerner, Ottokar Stundner, Anna Seisl, Heidi Fiegl, Lukas Gasteiger
INTRODUCTION: Injecting mixtures of local anesthetics with or without adjuvants is a common practise in regional and particularly obstetric anesthesia to decrease block onset time and/or augment epidural analgesia for cesarean section. While evidence on the efficacy of this practise is equivocal, little is known about its safety in terms of the pharmacologic compatibility of local anesthetics. METHODS: We assessed the grade of crystallization in individual mixtures of seven local anesthetics (bupivacaine, ropivacaine, lidocaine, procaine, chloroprocaine, mepivacaine, prilocaine) with or without four adjuvants (sodium bicarbonate, dexamethasone, clonidine, fentanyl) using a semiquantitative light microscopy scale (ranging from 0 to 5), repeatedly for up to 60 min and performed correlation analysis between grade of crystallization and initial solution pH...
March 5, 2024: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/38380269/rapid-production-of-the-anaesthetic-mepivacaine-through-continuous-portable-technology
#2
JOURNAL ARTICLE
Pablo Díaz-Kruik, Francesca Paradisi
Local anaesthetics such as mepivacaine are key molecules in the medical sector, so ensuring their supply chain is crucial for every health care system. Rapid production of mepivacaine from readily available commercial reagents and (non-dry) solvents under safe conditions using portable, continuous apparatus could make an impactful difference in underdeveloped countries. In this work, we report a continuous platform for synthesising mepivacaine, one of the most widely used anaesthetics for minor surgeries. With a focus on sustainability, reaction efficiency and seamless implementation, this platform afforded the drug in 44% isolated yield following a concomitant distillation-crystallisation on a gram scale after N -functionalisation and amide coupling, with full recovery of the solvents and excess reagents...
February 19, 2024: Green Chemistry: An International Journal and Green Chemistry Resource: GC
https://read.qxmd.com/read/38321405/effect-of-ropivacaine-mepivacaine-or-the-combination-of-ropivacaine-and-mepivacaine-for-epidural-anaesthesia-on-the-postoperative-recovery-in-patients-undergoing-caesarean-section-a-randomized-prospective-double-blind-study
#3
RANDOMIZED CONTROLLED TRIAL
Muye Wang, Chen Liao, Xiaocui Li, Weiming Chen, Yujie Li, Wei Zhang, Shouping Wang
BACKGROUND: Anaesthetic methods and drugs with rapid onset, rapid recovery and better postoperative analgesia are more suitable for rapid recovery in obstetric anaesthesia. We formulated the following hypothesis: a combination of mepivacaine and ropivacaine could provide a longer analgesic effect and have more advantages in terms of rapid-recovery indicators. METHODS: A total of 180 pregnant women scheduled to undergo elective caesarean sections were randomly assigned to three surgical groups, which received 2% mepivacaine (Group M), 2% mepivacaine + 0...
February 7, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38307613/mepivacaine-dosing-for-spinal-anesthesia-in-pediatric-orthopedic-surgery-a-retrospective-chart-review
#4
JOURNAL ARTICLE
Michelle Carley, Miriam Sheetz, Justas Lauzadis, Haoyan Zhong, Kathryn DelPizzo
BACKGROUND: Mepivacaine is an intermediate-acting local anesthetic used for spinal anesthesia in adults. Currently, there are no published dosing guidelines for spinal mepivacaine in patients under age 18. AIMS: The purpose of this study is to describe the clinically used doses of mepivacaine by weight and age for orthopedic surgery in pediatrics. METHODS: We performed a retrospective chart review of patients aged 0-18 who received mepivacaine for spinal anesthesia from 2016 to 2022...
February 2, 2024: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/38276054/effectiveness-of-acupotomy-combined-with-epidural-steroid-injection-for-lumbosacral-radiculopathy-a-randomized-controlled-pragmatic-pilot-study
#5
JOURNAL ARTICLE
Jin-Hyun Lee, Sang-Hyun Lee, Hae Sun Suh, Man-Suk Hwang, Semin Jang, Sooil Choi, Young-Soo Lim, Sang Hyun Byun, Sang-Hoon Yoon, Sukhee Park, Tae-Yong Park
Background and Objectives : This pilot study aimed to evaluate the clinical effectiveness, cost-effectiveness, and safety of acupotomy combined with epidural steroid injection (ESI) in lumbosacral radiculopathy and examine its feasibility for the main study. Materials and Methods : This randomized, controlled, two-arm, parallel, assessor-blinded, pragmatic study included 50 patients with severe lumbosacral radiculopathy who had insufficient improvement after an ESI. Patients were randomized (1:1 ratio) into a combined treatment (acupotomy + ESI, experimental) and an ESI single treatment (control) group...
January 19, 2024: Medicina
https://read.qxmd.com/read/38202113/intra-articular-local-anesthetics-in-temporomandibular-disorders-a-systematic-review-and-meta-analysis
#6
REVIEW
Karolina Lubecka, Kamila Chęcińska, Filip Bliźniak, Maciej Chęciński, Natalia Turosz, Adam Michcik, Dariusz Chlubek, Maciej Sikora
This systematic review with meta-analysis was conducted to evaluate the effectiveness of local anesthetic administration into temporomandibular joint cavities in relieving pain and increasing mandibular mobility. Randomized controlled trials were included with no limitation on report publication dates. Final searches were performed on 15 October 2023, using engines provided by the US National Library, Bielefeld University, and Elsevier Publishing House. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool...
December 24, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38145776/the-efficacy-of-injecting-a-distillate-of-the-pitcher-plant-sarraceniaceae-adjacent-to-the-palmar-digital-nerves-of-horses-to-ameliorate-lameness-caused-by-digital-pain
#7
JOURNAL ARTICLE
Leanda Livesey, Fred DeGraves, Courtney Allred, Lindsey Boone, John Schumacher
This study aimed to determine the efficacy of instilling extract of the pitcher plant around the palmar digital nerves of horses to ameliorate digit pain causing lameness. Five mixed breed horses were recruited. Horses were determined to be lame because of pain in the distal portion of one or both thoracic limbs by a positive response to a basisesamoid nerve block using mepivacaine hydrochloride. Gait was evaluated pre- and post-nerve block at 30 min, 3, 7,14 and 21 days. At the 3-week evaluation, the basisesamoid nerve block was repeated using the extract, and the gait was evaluated at similar times...
December 23, 2023: Journal of Equine Veterinary Science
https://read.qxmd.com/read/38103803/spinal-versus-general-anesthesia-for-outpatient-total-hip-and-knee-arthroplasty-in-the-ambulatory-surgery-center-a-matched-cohort-study
#8
JOURNAL ARTICLE
Tyler E Calkins, Evan P Johnson, Renn Eason, William M Mihalko, Marcus C Ford
BACKGROUND: Spinal anesthesia is the predominant regimen in outpatient total joint arthroplasty (TJA), but induction often is unsuccessful, unobtainable, or against patient preference. We compared outcomes of same-day discharge (SDD) TJA with spinal versus general anesthesia in a free-standing ambulatory surgery center (ASC). METHODS: We took 105 general anesthesia TJA and one-to-one nearest-neighbor matched them to 105 spinal anesthesia TJA over 7 years at one ASC...
December 14, 2023: Journal of Arthroplasty
https://read.qxmd.com/read/38041616/retinal-artery-occlusion-after-ophthalmic-surgery-under-regional-anaesthesia-a-narrative-review
#9
REVIEW
Alfred Wy Chua, Matthew J Chua, Brian P Harrisberg, Chandra M Kumar
Two recent cases of central retinal artery occlusion under otherwise uncomplicated sub-Tenon's block that resulted in significant visual loss after cataract surgery prompted us to undertake a literature review of such cases. We identified 97 cases of retinal artery occlusion after ophthalmic surgery under regional anaesthesia that had no immediate signs of block-related complications. These occurred after various intraocular (87%) and extraocular (13%) operations, across a wide range of ages (19-89 years) on patients with (59%) or without (39%) known risk factors...
March 2024: Anaesthesia and Intensive Care
https://read.qxmd.com/read/38034168/comparison-of-lidocaine-and-mepivacaine-for-variation-in-regional-tissue-oxygenation-in-stellate-ganglion-block-a-randomized-double-blind-crossover-trial
#10
JOURNAL ARTICLE
Hidetaka Kuroda, Norika Katagiri, Keita Kagawa, Uno Imaizumi, Noboru Ishikawa, Yoshiyuki Shibukawa, Yoshinari Morimoto, Takuro Sanuki
Introduction This prospective, randomized, double-blind, crossover trial aimed to investigate the effect of different types of local anesthetics on regional tissue blood oxygenation on the stellate ganglion block (SGB). Methods Twenty eligible patients were recruited for this study; 16 of whom were allocated to the study protocol. Participants were randomized into one of the two crossover sequences: 1% lidocaine hydrochloride or 1% mepivacaine hydrochloride, and received SGBs with 6 mL of any one of the local anesthetics, followed by a washout period of more than 24 hours, and then received SGBs by substituting the two local anesthetics...
October 2023: Curēus
https://read.qxmd.com/read/38020254/effect-of-local-anesthetics-on-renal-function-an-animal-study-in-iran
#11
JOURNAL ARTICLE
Rasul Gheisari, Masoud Saatchi, Firoozeh Estakhri, Mehrdad Vossoughi, Mohammad Bazaei, Zahra Khosravani
BACKGROUND: Although most of the metabolism of local anesthetics (LAs) takes place in the liver, no study has investigated the effect of these anesthetics on the kidney function of single-kidney humans or animals. The present study was conducted to examine the effect of LAs on renal function in single-kidney rats. MATERIALS AND METHODS: The present experimental animal study with two control groups was done in an animal laboratory. Forty-two rats were randomly assigned to seven groups of six rats, including two control groups and five experimental groups...
2023: Dental Research Journal
https://read.qxmd.com/read/38009737/local-anesthetic-thoracoscopy-for-undiagnosed-pleural-effusion
#12
JOURNAL ARTICLE
Uffe Bodtger, José M Porcel, Rahul Bhatnagar, Mohammed Munavvar, Casper Jensen, Paul Frost Clementsen, Daniel Bech Rasmussen
Local anesthetic thoracoscopy (LAT) is a minimally invasive diagnostic procedure gaining recognition among chest physicians for managing undiagnosed pleural effusions. This single-port procedure is conducted with the patient under mild sedation and involves a contralateral decubitus position. It is performed in a sterile setting, typically a bronchoscopy suite or surgical theater, by a single operator with support from a procedure-focused nurse and a patient-focused nurse. The procedure begins with a thoracic ultrasound to determine the optimal entry point, usually in the IV-V intercostal space along the midaxillary line...
November 10, 2023: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/37999201/development-of-a-predictive-statistical-pharmacological-model-for-local-anesthetic-agent-effects-with-bayesian-hierarchical-model-parameter-estimation
#13
JOURNAL ARTICLE
Toshiaki Ara, Hiroyuki Kitamura
As an alternative to animal use, computer simulations are useful for predicting pharmacokinetics and cardiovascular activities. For this purpose, we constructed a statistical model to simulate the effects of local anesthetic agents. To train the model, animal experiments were performed on 6-week-old male Hartley guinea pigs. Firstly, the guinea pigs' backs were shaved, then local anesthetic agents were subcutaneously injected, with subsequent stimulation of the anesthetized site with a needle six times at regular intervals...
November 15, 2023: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/37866512/liposomal-bupivacaine-interscalene-blocks-demonstrate-a-greater-proportion-of-total-shoulder-arthroplasty-patients-with-clinically-tolerable-pain-a-retrospective-quality-improvement-study-of-491-patients
#14
JOURNAL ARTICLE
Johnny K Lee, Steven Greenberg, Richard Wixson, Claire Heshmat, Andrew Locke, Travette Daniel, Jason Koh
OBJECTIVE: To evaluate the effects of liposomal bupivacaine use for interscalene blocks on postoperative analgesia in total shoulder arthroplasty patients. METHODS: De-identified total or reverse total shoulder arthroplasty patients between 2018 and 2021 were analyzed. Patients were grouped into single shot interscalene block with liposomal bupivacaine (LB) with plain bupivacaine, other block (OB) with other local anesthetics (mepivacaine, ropivacaine, or plain bupivacaine), or no block (NB)...
October 20, 2023: Journal of ISAKOS
https://read.qxmd.com/read/37865418/efficacy-and-safety-of-articaine-in-3-year-old-children-for-dental-procedures-a-protocol-for-a-clinical-randomised-control-trial-in-saudi-arabia
#15
JOURNAL ARTICLE
Murad Alrashdi, Atyaf Alhunti, Asya Almansour
INTRODUCTION: Despite the wide use of articaine in paediatric dentistry owing to its proven effectiveness and safety, articaine application in children <4 years remains controversial due to a lack of data on the use of articaine in very young children. This trial aims to examine the efficacy and safety of 4% articaine compared with 2% mepivacaine in children 3-4 years old requiring dental extractions. We aim to assess local anaesthetic efficacy and safety through a local anaesthetic infiltration technique for primary teeth requiring dental extraction in children 3 years old...
October 21, 2023: BMJ Open
https://read.qxmd.com/read/37701662/standing-sedation-management-of-a-domesticated-reindeer-for-third-eyelid-removal
#16
Sara J Lawrence-Mills, Maria-Christine Fischer, Sophie Talbot, Jenny Reed, Carolina Palacios Jimenez
BACKGROUND: Reindeer are becoming popular animals within petting farms. Few case reports describe the sedation of domesticated reindeer, but none describe the use of ocular local anesthetic blocks in this species. CASE DESCRIPTION: A 9-year-old, female, Svalbard reindeer ( Rangifer tarandus platyrhynchus ) presenting for removal of a squamous cell carcinoma involving the third eyelid. Standing sedation was performed using initial boluses of medetomidine and butorphanol via intramuscular injection before catheter placement and maintenance with a variable rate infusion of medetomidine...
August 2023: Open Veterinary Journal
https://read.qxmd.com/read/37643724/modified-abaxial-sesamoid-nerve-block-provides-enhanced-proximal-diffusion-compared-to-basisesamoid-block-and-lower-proximal-diffusion-than-traditional-low-plantar-nerve-block-in-equine-hind-limbs-ex-vivo-and-in-vivo-study
#17
JOURNAL ARTICLE
Roberto J Estrada, Genner J Alvarado, Alejandro Vargas, Jose Vargas, Diana Vargas, Randall Chacón, Patricio Razquin, Rafael Vindas
OBJECTIVE: To determine the proximal diffusion distance of radiopaque contrast medium and mepivacaine/methylene blue solution and incidence of inadvertent intrasynovial and intravascular injections of modified sesamoid nerve block (MASB) when compared with traditional plantar nerve analgesia techniques of the equine distal hind limb. SAMPLE: Ex vivo model: 18 hind limbs; and in vivo model: 5 horses in a crossover study. METHODS: In the ex vivo model, a mepivacaine/methylene blue solution was used to compare the diffusion distance between MASB, basisesamoid block (BSB), and traditional low plantar block (TLPB)...
August 29, 2023: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/37614207/a-randomised-study-of-turp-after-intraprostatic-injection-of-mepicacaine-adrenaline-versus-regular-turp-in-patients-with-luts-bpo
#18
RANDOMIZED CONTROLLED TRIAL
Fredrik Stenmark, Lars Brundin, Olof Gunnarsson, Henrik Kjölhede, Edvard Lekås, Ralph Peeker, Marianne Månsson, Jonas Richthoff, Johan Stranne
INTRODUCTION: During transurethral resection of the prostate (TURP), the most established surgical treatment of lower urinary tract symptoms (LUTS) due to benign prostatic obstruction (BPO), the prostate can bleed profusely, bringing about anaemia and compromised oxygen delivery to the entire body. OBJECTIVE: The primary objective of this study was to assess the efficacy of mepivacaine and adrenaline (MA) injected into the prostate on bleeding. The primary endpoint was to measure blood loss per resected weight of prostate tissue...
August 24, 2023: Scandinavian Journal of Urology
https://read.qxmd.com/read/37534092/the-dose-response-relationships-of-the-direct-scavenging-activity-of-amide-based-local-anesthetics-against-multiple-free-radicals
#19
JOURNAL ARTICLE
Yukiko Sato, Shigekiyo Matsumoto, Kazue Ogata, Kira Bacal, Misato Nakatake, Takaaki Kitano, Osamu Tokumaru
This study aimed to illustrate the dose-response relationships of the direct scavenging activity of amide-based local anesthetics against multiple free radicals in vitro . We have demonstrated that amide-type local anesthetics selectively and directly scavenge some free radicals. Three kinds of free radicals were eliminated by all the four local anesthetics examined. Mepivacaine, lidocaine, bupivacaine, and dibucaine scavenged hydroxyl radicals in dose-dependent manners. Ascorbyl free radicals were also scavenged in dose-dependent manners, and lastly singlet oxygen was scavenged in dose-dependent manners...
July 2023: Journal of Clinical Biochemistry and Nutrition
https://read.qxmd.com/read/37527165/comparison-of-mepivacaine-2-and-isobaric-bupivacaine-0-5-spinal-anesthetics-for-total-knee-arthroplasty
#20
JOURNAL ARTICLE
Nicoli F Bettin, Kaitlyn L Crawford, Jessica J Peterson
Spinal anesthesia is an option for patients during total knee arthroplasty (TKA) procedures. Spinal anesthesia can offer advantages and disadvantages to the patient's experience and outcomes. We conducted an evidence-based, quality improvement project comparing mepivacaine 2% and isobaric bupivacaine 0.5% and retrospectively assessed specific intraoperative and postoperative outcomes that were of interest to the staff at the hospital where the project was completed. Primary outcome measures of interest included intraoperative heart rate, blood pressure, vasopressor use, fluid resuscitation, postoperative pain scores, use of opioid analgesic medications, and time to ambulation after administration of the spinal anesthetic...
August 2023: AANA Journal
keyword
keyword
95734
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.