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Elodie Lefrançois, Pierre Esseiva, Jean-Pierre Gervasoni, Sonia Lucia, Frank Zobel, Marc Augsburger
BACKGROUND: For the first time in Switzerland, an analysis of residual contents from used syringes collected from low threshold facilities was performed. This preliminary study is part of a wider project aiming to understand patterns of injecting drug use over time. METHODS: Among the 100,000 syringes exchanged annually by the ABS foundation (Accueil Bas Seuil), 113 were collected following a purposive sampling method and analysed by gas chromatography coupled with mass spectrometry (GC-MS)...
September 2016: Forensic Science International
G Asselborn, M Yegles, R Wennig
Background : Remifentanil (Ultiva®) is a recently introduced esterase-metabolized potent opioid (EMO) μ-receptor agonist with a rapid onset and offset of action for use as part of general anaesthesia in association with isoflurane or propofol or with midazolam (Dormicum®) and in combination with mivacurium. Case Report : A nurse from the anaesthesiology department of a hospital was found dead at home with a syringe and empty vials of Ultiva® (2 mg) and of Dormicum ® (1 mg/mL). At autopsy several injection sites were found on her body...
2002: Acta Clinica Belgica
Tamas Bartfai, Ming-wei Wang
The task of finding selective and stable peptide receptor agonists with low molecular weight, desirable pharmacokinetic properties and penetrable to the blood-brain barrier has proven too difficult for many highly coveted drug targets, including receptors for endothelin, vasoactive intestinal peptide and galanin. These receptors and ligand-gated ion channels activated by structurally simple agonists such as glutamate, glycine and GABA present such a narrow chemical space that the design of subtype-selective molecules capable of distinguishing a dozen of glutamate and GABA receptor subtypes and possessing desirable pharmacokinetic properties has also been problematic...
July 2013: Acta Pharmacologica Sinica
Hanna Mackiewicz-Nartowicz, Anna Sinkiewicz, Arleta Bielecka
OBJECTIVE: The aim of this study was to report our experience with laryngovideostroboscopy (LVS) in consecutively examined children patients. METHODS: The study included 150 children (2.5-14 years of age) diagnosed with dysphonia. Patients were divided into three age groups: group I - from 2.5 to 6 years of age (n = 31), group II - from 6 to 10 years of age (n = 73), and group III--from 10 to 14 years of age (n = 46). LVS was performed during the second visit. 3...
August 2011: International Journal of Pediatric Otorhinolaryngology
Jin Hyun Song, Seung Whan Doo, Won Jae Yang, Yun Seob Song, Geun Woo Kim, Ja Hyeon Ku, Chang Ho Lee
PURPOSE: Although transrectal ultrasound-guided prostate biopsy is useful for diagnosing prostate cancer, it is a painful procedure. There are many methods for providing pain relief and for treating discomfort during the procedure, but occasionally these are reported to be of limited use. We aimed to evaluate the value and safety of midazolam-induced anesthetic transrectal ultrasound-guided prostate biopsy. MATERIALS AND METHODS: From August 2008 to December 2009, 104 male patients, who were examined with transrectal ultrasound-guided prostate 12-core biopsy, were randomly assigned to two groups...
March 2011: Korean Journal of Urology
V I Parshin, N K Pastukhova
The paper deals with the specific features of anesthetic maintenance (ketamine, diprivan, dormicum, perfalgan, promedol) during circular face lifting without artificial ventilation. All intravenous anesthesia procedures have yielded good results. Narcotic analgesics may be removed from the anesthetic maintenance scheme, ruling out the necessity of their licensing, storing, and recording. The use of perfalgan causes no hallucinogenic reactions and offers the optimum level of anesthesia. During face lifting, 2...
March 2010: Anesteziologiia i Reanimatologiia
Ozgul Baygin, Haluk Bodur, Berrin Isik
BACKGROUND AND OBJECTIVE: In paediatric dentistry, when anxiety, fear of dental procedures or behavioural impairment precludes the conduct of dental treatments, sedation procedures are required. However, sedation at the desired level might not be achieved despite administration of various agents. The present study aimed to evaluate the effectiveness of oral premedication with different agents on children scheduled for dental treatment under nitrous oxide/oxygen (N2O/O2) sedation. METHODS: The present research was approved by the Ethics Committee of Gazi University Faculty of Medicine...
April 2010: European Journal of Anaesthesiology
Anita Gothelf, Pernille Hojman, Julie Gehl
Analgesic and anesthetic drugs may have an impact on the results achieved from animal experiments. In the study presented here, we try to enlighten whether anesthesia with fentanyl/fluniasone and midazolam (Hypnorm and Dormicum) has an influence on measurements of hemoglobin in mice. In a cross-over study, we have compared hemoglobin levels in two groups of mice: anesthetized versus non-anesthetized and found significant decrease in hemoglobin levels in the anesthetized group (p < 0.05) unrelated to which group received the anesthesia...
2009: Biological Procedures Online
Berrin Isik, Ozgül Baygin, Haluk Bodur
AIM: Failure of dental treatment caused by anxiety is a common problem in children. Oral midazolam has been the most commonly used premedication for pediatric patient but the use of midazolam may be associated with paradoxical reactions in children. Melatonin may induce a natural sleepiness and improve sedation. We have investigated premedication with melatonin compared with midazolam in children under nitrous oxide/oxygen (N(2)O/O(2)) sedation for dental treatment. METHODS: In a randomized study, 60 children received either 3 mg of melatonin [Melatonina (3 mg(R)) 60 min before the procedure (n = 15); group I], 0...
July 2008: Paediatric Anaesthesia
Henry H L Chan, C H Yang, Joseph C K Leung, W I Wei, K N Lai
BACKGROUND AND OBJECTIVE: Non-ablative skin rejuvenation treatments that involve the use of laser/light sources together with cooling devices have gained much popularity in recent years due to the lack of down time that is associated with them. One important but neglected issue is long-term safety. Does the repeated use of non-ablative skin rejuvenation lead to photoaging? Are we creating another sun-bed phenomenon? Recently, we performed an in vitro study to examine the effect of sub-lethal QS 755 nm lasers on the expression of p16INK4a on melanoma cell lines, and found that sub-lethal laser damage could increase DNA damage, which led to an increase in p16 expression...
January 2007: Lasers in Surgery and Medicine
Tue E H Christoffersen, Mark Aplin, Claes C Strom, Soren P Sheikh, Ole Skott, Peter K Busk, Stig Haunso, Lars B Nielsen
Both atrial (ANP) and brain (BNP) natriuretic peptide affect development of cardiac hypertrophy and fibrosis via binding to natriuretic peptide receptor (NPR)-A in the heart. A putative clearance receptor, NPR-C, is believed to regulate cardiac levels of ANP and BNP. The renin-angiotensin system also affects cardiac hypertrophy and fibrosis. In this study we examined the expression of genes for the NPRs in rats with pressure-overload cardiac hypertrophy. The ANG II type 1 receptor was blocked with losartan (10 mg...
April 2006: American Journal of Physiology. Heart and Circulatory Physiology
M N Lebedeva, A M Ageenko, E V Bykova, S I Kirilina, D S Luk'ianov
Vertebral operations are highly traumatic, prolonged and can cause significant blood loss, which requires effective anesthesiological defense. Inclusion of clofelin, a stress protector, into the anesthesiological provision scheme is an effective way of potentiating the protection of a patient from surgical stress. The development of neurological disorders is a severest complication during surgical interventions in vertebral surgery. The task that is important for a surgeon and an anesthesiologist in performing such operations is the maximum early recovery of patients from anesthesia and their muscular activity in the postoperative period in order to make a timely evaluation of their neurological status...
May 2005: Anesteziologiia i Reanimatologiia
A M Ovezov, V V Likhvantsev, O V Petrov
Thirty patients from 3 groups that differed only in the scope of monitoring were examined to study the efficiency of combined neurophysiological and autonomic nervous monitoring in the assess of the quality of anesthesiological protection during highly traumatic surgical interventions made in abdominal patients under combined general anesthesia based on long-term graded epidural naropine (3 mg/ml) infusion at the thoracic level Addition of the Harvard standard with monitoring the information saturation of EEG made it possible to maintain the depth of anesthesia, by reducing the dose of dormicum by 20% (p < 0...
March 2005: Anesteziologiia i Reanimatologiia
Thomas Laube, Hyunil Krohner, Gabriele Helga Franke, Claudia Brockmann, Klaus Peter Steuhl
PURPOSE: To evaluate and compare the efficacy of oral clorazepate dipotassium (Tranxilium) and intravenous midazolam (Dormicum) as premedication agents in retrobulbar anesthesia and clear corneal phacoemulsification with intraocular lens (IOL) implantation. SETTING: Department of Ophthalmology, University of Essen, Essen, Germany. METHODS: In a prospective clinical trial, 97 consecutive patients (97 eyes) having phacoemulsification with implantation of a foldable IOL were randomized to 2 groups...
October 2003: Journal of Cataract and Refractive Surgery
I F Ostreĭkov, S A Pivovarov, V V Milenin, Ia I Vasil'ev
34 children selected into two groups due to age (patients from 4 to 7 year old were included in the 1st group, the 2nd group consisted of children, aged from 8 years to 14 years, were premedicated with dormicum, and in other 37 patients standard premedication was applied. The state of cardiovascular system was estimated by means of indices of central hemodynamics and heart rate monitoring data. Every patient was examined both before and 30 minutes after premedication. While standard premedication activates central hemodynamics, increases, especially in older children, left ventricular performance, premedication with dormicum influence neither indices of central hemodynamics nor left ventricular performance, and causes moderate sympatical activation by dormicum in dose of 0...
July 2002: Anesteziologiia i Reanimatologiia
O Ia Zamiralova, A M Shcherbakov, A I Evtiukhin
The evidence on the attitude of 60 cancer out-patients to fibrocolonoscopy carried out under general anesthesia was evaluated versus different procedures of intravenous injection. Most patients were scared prior to examination; 83.3% felt sleepy during the procedure while 85% of those anesthetized wouldn't mind receiving narcosis for repeat examination. Propofol (diprivan) alone showed an advantage over midazolam (dormicum) in being more tolerable and cutting stay at hospital by a third. Ketamin proved undesirable due to psychomimetic effects and delayed regaining of consciousness...
2002: Voprosy Onkologii
Asta Juzeniene, Petras Juzenas, Olav Kaalhus, Vladimir Iani, Johan Moan
Significant amounts of protoporphyrin IX (PpIX) are formed after 6 min of topical application of 5-aminolevulinic acid (ALA) and its hexylester derivative, whereas PpIX is formed after 10 min of topical application of ALA-methylester derivative in normal mouse skin at 37 degrees C. Lowering the skin temperature to 28-32 degrees C by the administration of the anesthetic Hypnorm-Dormicum reduces the PpIX fluorescence by a factor of 2-3. Practically no PpIX was formed as long as the skin temperature was kept at 12-18 degrees C...
October 2002: Photochemistry and Photobiology
Kh Kh Kharrasov, V V Klimenko, P P Sergin
The efficiencies of modern intravenous anesthetics, analgesics, and hypnotics (dormicum, diprivan, ketamine, and fentanyl) in various combinations for artificial abortions was evaluated. Hemodynamic parameters, autonomic status, and clinical signs of awakening were evaluated. The most effective protection was attained with a combination of diprivan, dormicum, and fentanyl.
January 2002: Anesteziologiia i Reanimatologiia
G Asselborn, M Yegles, R Wennig
BACKGROUND: Remifentanil (Ultiva) is a recently introduced esterase-metabolized potent opioid (EMO) mu-receptor agonist with a rapid onset and offset of action for use as part of general anaesthesia in association with isoflurane or propofol or with midazolam (Dormicum) and in combination with mivacurium. CASE REPORT: A nurse from the anaesthesiology department of a hospital was found dead at home with a syringe and empty vials of Ultiva (2 mg) and of Dormicum (1 mg/mL)...
2002: Acta Clinica Belgica
R N Radev, N P Maneva, Kh I Khristova, V Tsvetkov, G D Dimitrov
47 women on which sectio cesarean has been done in occasion of belvic-fetal disproportion, anatomical abnormalities of the pelvis, bad position of presentation. We studies presence of consciousnes spontaneous realtion to pain and possibility for contact according the method of Tunstall M.E. It was proved that the use of benzodiazepin derivate--Dormicum impacts substantially influensences of the studied processes. Introduction anaesthetics (thiopental-kalipsol, dormicum-kalipsol and thiopental and helothan in 0...
1999: Akusherstvo i Ginekologii︠a︡
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