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JOURNAL ARTICLE
Ankur R Sangoi, Kristyna Pivovarcikova, Mahmut Akgul, Sean R Williamson, Monica Ulamec, Joanna Dominica Rogala, Petr Martinek, Tomas Vanecek, Ondrej Hes, Reza Alaghehbandan
In addition to "classic" and eosinophilic subtype, chromophobe renal cell carcinoma (RCC) is well-known to demonstrate various morphological patterns including adenomatoid, microcystic, pigmented, multicystic, papillary, neuroendocrine-like, and small cell-like, all of which are important to appreciate for accurate diagnosis. Herein, we expand on a unique chromophobe RCC morphology not previously described consisting of tumor cells with extensive stromal retraction, mimicking upper urothelial tract micropapillary carcinoma (MPC)...
April 3, 2024: International Journal of Surgical Pathology
#22
JOURNAL ARTICLE
Matthieu Groh, Laurène Fenwarth, Mathilde Labro, Augustin Boudry, Elise Fournier, Mathieu Wemeau, Alice Marceau-Renaut, Rafael Daltro de Oliveira, Julie Abraham, Marly Barry, Philippe Blanche, Quentin Bodard, Thorsten Braun, Safia Chebrek, Matthieu Decamp, Cécile-Audrey Durel, Edouard Forcade, Mathieu Gerfaud-Valentin, Camille Golfier, Clément Gourguechon, Nathalie Grardel, Olivier Kosmider, Nihal Martis, Sarah Melboucy Belkhir, Fatiha Merabet, Adrien Michon, Stéphane Moreau, Cécile Morice, Antoine Néel, Franck E Nicolini, Laurent Pascal, Florence Pasquier, Andrea Pieragostini, Catherine Roche-Lestienne, Philippe Rousselot, Louis Terriou, Anne Thiebaut-Bertrand, Jean-François Viallard, Claude Preudhomme, Jean-Emmanuel Kahn, Guillaume Lefevre, Nicolas Duployez
We investigated using a custom NGS panel of 149 genes the mutational landscape of 64 consecutive adult patients with tyrosine kinase fusion-negative hypereosinophilia (HE)/hypereosinophilic syndrome (HES) harboring features suggestive of myeloid neoplasm. At least one mutation was reported in 50/64 (78%) patients (compared to 8/44 (18%) patients with idiopathic HE/HES/HEUS used as controls; p < .001). Thirty-five patients (54%) had at least one mutation involving the JAK-STAT pathway, including STAT5B (n = 18, among which the hotspot N642H, n = 13), JAK1 (indels in exon 13, n = 5; V658F/L, n = 2), and JAK2 (V617F, n = 6; indels in exon 13, n = 2)...
April 2, 2024: American Journal of Hematology
#23
JOURNAL ARTICLE
F M Ayyaz, J Joyner, M Cheetham, Twr Briggs, W K Gray
INTRODUCTION: The aim of this study was to investigate the safety of day-case laparoscopic cholecystectomy, and the association between day-case rates and, post the COVID-19 pandemic, recovery of activity to prepandemic levels for integrated care boards (ICBs) in England. METHODS: This was a retrospective observational study of the Hospital Episodes Statistics (HES) data set. Elective laparoscopic cholecystectomies for the period 1 January 2019 to 31 December 2022 were identified...
April 2, 2024: Annals of the Royal College of Surgeons of England
#24
JOURNAL ARTICLE
Lingtao Kang, Xiaolei Han, Xia Chang, Zhipeng Su, Fuhua Fu, Yang Shan, Jiajing Guo, Gaoyang Li
Our study aimed at developing polymer micelles that possess redox sensitivity and excellent controlled release properties. 3,3'-dithiodipropionic acid (DTDPA, Abbreviation in synthetic polymers: SS) was introduced as ROS (Reactive oxygen species)response bond and connecting arm to couple hydroxyethyl starch (HES) with oleanolic acid (OA), resulting in the synthesis of four distinct grafting ratios of HES-SS-OA. FTIR (Fourier Transform infrared spectroscopy) and 1 H NMR (1 H Nuclear magnetic resonance spectra) were used to verify the triumphant combination of HES-SS-OA...
March 27, 2024: International Journal of Biological Macromolecules
#25
JOURNAL ARTICLE
William Shomali, Jason Gotlib
DISEASE OVERVIEW: The eosinophilias encompass a broad range of non-hematologic (secondary or reactive) and hematologic (primary or clonal) disorders with the potential for end-organ damage. DIAGNOSIS: Hypereosinophilia (HE) has generally been defined as a peripheral blood eosinophil count greater than 1.5 × 109 /L, and may be associated with tissue damage. After the exclusion of secondary causes of eosinophilia, diagnostic evaluation of primary eosinophilias relies on a combination of various tests...
March 29, 2024: American Journal of Hematology
#26
REVIEW
A M Marra, C M Rossi, M A Piga, G Moroncini, M B Bilò
Eosinophil-associated diseases (EADs) refer to heterogeneous conditions in which eosinophils are believed to play critical pathological roles. They encompass common respiratory conditions, such as asthma, chronic rhinosinusitis with nasal polyps (CRSwNP), less common primary eosinophilic disorders of gastrointestinal tract, and rare conditions including eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES). A literature search was carried out in January 2024 in the MEDLINE and Scopus databases using the PubMed search engine (PubMed, National Library of Medicine, Bethesda, MD)...
March 28, 2024: European Annals of Allergy and Clinical Immunology
#27
JOURNAL ARTICLE
Yu Liang, Xinyu Zhao, Yujia Xu, Yonglin Lu, Lishuang Lv
There is considerable research evidence that α-dicarbonyl compounds, including glyoxal (GO) and methylglyoxal (MGO), are closely related to many chronic diseases. In this work, after comparison of the capture capacity, reaction pathway, and reaction rate of synephrine (SYN) and neohesperidin (NEO) on GO/MGO in vitro , experimental mice were administrated with SYN and NEO alone and in combination. Quantitative data from UHPLC-QQQ-MS/MS revealed that SYN/NEO/HES (hesperetin, the metabolite of NEO) could form the GO/MGO-adducts in mice (except SYN-MGO), and the levels of GO/MGO-adducts in mouse urine and fecal samples were dose-dependent...
March 26, 2024: Journal of Agricultural and Food Chemistry
#28
JOURNAL ARTICLE
Da Huang, Yongming Wang, Chenlan Xu, Minglang Zou, Yangcan Ming, Fang Luo, Zhenjin Xu, Ying Miao, Na Wang, Zhenyu Lin, Zuquan Weng
Curcumin (CUR) is a natural polyphenol that holds promise for treating ulcerative colitis (UC), yet oral administration of CUR exhibits limited bioavailability and existing formulations for oral delivery of CUR often suffer from unsatisfactory loading capacity. This study presents hydroxyethyl starch-curcumin microspheres (HC-MSs) with excellent CUR loading capacity (54.52 %), and the HC-MSs can further encapsulate anti-inflammatory drugs dexamethasone (DEX) to obtain a combination formulation (DHC-MSs) with high DEX loading capacity (19...
March 23, 2024: International Journal of Biological Macromolecules
#29
JOURNAL ARTICLE
Sarah Shidid, Pakinam Mekki, Tamar A Smith-Norowitz
OBJECTIVE: To present the case of an athlete with hypereosinophilic syndrome (HES). CASE REPORT: We present a 25-year-old female athlete, with no significant past medical history, who had a two-month history of progressive dry cough, wheezing, exertional dyspnea, and chest pain. Physical examination revealed patient to be febrile to 101.6 degrees Fahrenheit and tachycardic to 120 beats per minute with new leukocytosis of 35.9x109 /L and eosinophilia of 24,000/μL...
January 2024: Annals of Clinical and Laboratory Science
#30
JOURNAL ARTICLE
Chaoqun Li, Yaogang Zhang, Mingquan Pang, Yong Zhang, Chunhui Hu, Haining Fan
Albendazole (ABZ) is the primary treatment for alveolar echinococcosis (AE); however, its limited solubility impacts oral bioavailability, affecting therapeutic outcomes. In this study, various ABZ-solubilizing formulations, including albendazole crystal dispersion system (ABZ-CSD), albendazole hydrochloride-hydroxypropyl methylcellulose phthalate composite (TABZ-HCl-H ), and albendazole hydroxyethyl sulfonate-hydroxypropyl methylcellulose phthalate composite (TABZ-HES-H ), were developed and evaluated. Physicochemical properties as well as liver enzyme activity were analyzed and their pharmacodynamics in an anti-secondary hepatic alveolar echinococcosis (HAE) rat model were investigated...
March 19, 2024: Antimicrobial Agents and Chemotherapy
#31
JOURNAL ARTICLE
Laurie Smith, Emily Wilkes, Chris Rolfe, Petra Westlake, Julie Cornish, Paul Brooks, Jared Torkington
Background: Incisional hernia (IH) is a common complication of abdominal surgery affecting between 12.8% and 30% of patients. In spite of this, rates of IH repair remain low, at around 5% in the literature. We aimed to assess the rate of IH repair in the UK across surgical specialties and the cost burden associated with IH repair. Methods: This is a retrospective observational study of patients undergoing abdominal surgery in England between 2012 and 2022 using the Hospital Episode Statistics (HES) database...
2024: J Abdom Wall Surg
#32
JOURNAL ARTICLE
Filiz Ozyigit, Ayse Nur Deger, Fatma Emel Kocak, Mehmet Fatih Ekici, Hasan Simsek, Ozlem Arık
PURPOSE: This study evaluated the protective effect of hesperidin on injury induced by gastric ischemia-reperfusion. METHODS: Fifty male Sprague Dawley rats (250-300 g) were divided into five groups: control (C), sham (S), ischemia (I), ischemia-reperfusion (I/R) and hesperidin + ischemia-reperfusion (Hes + I/R). Hesperidin was injected intraperitoneally at the dose of 100 mg/kg one hour before the experimental stomach ischemia-reperfusion. Celiac artery was ligated...
2024: Acta Cirúrgica Brasileira
#33
JOURNAL ARTICLE
Rachel Burns, Sacha Wyke, Yamina Boukari, Sirinivasa Vittal Katikireddi, Dominik Zenner, Ines Campos-Matos, Katie Harron, Robert W Aldridge
INTRODUCTION: Difficulties ascertaining migrant status in national data sources such as hospital records have limited large-scale evaluation of migrant healthcare needs in many countries, including England. Linkage of immigration data for migrants and refugees, with National Health Service (NHS) hospital care data enables research into the relationship between migration and health for a large cohort of international migrants. OBJECTIVES: We aimed to describe the linkage process and compare linkage rates between migrant sub-groups to evaluate for potential bias for data on non-EU migrants and resettled refugees linked to Hospital Episode Statistics (HES) in England...
2024: International Journal of Population Data Science
#34
JOURNAL ARTICLE
Xiaoyun Huang, Zhiming Liu, Weijian Zeng, Xiaoyu Ma, Yu Zhang, Muye Li, Jiutong Sun, Sheng Mao, Li Bian
Fenton catalytic medicine that catalyzes the production of ·OH without external energy input or oxygen as a substrate has reshaped the landscape of conventional cancer therapy in recent decades, yet potential biosafety concerns caused by non-safety-approved components restrict their clinical translation from the bench to the bedside. Herein, to overcome this dilemma, we elaborately utilizate safety-approved hetastarch, which has been extensively employed in the clinic as a plasma substitute, as a stabilizer participating in the copper chloride-initiated polymerization of pyrrole monomer before loading it with DOX...
March 6, 2024: RSC Advances
#35
JOURNAL ARTICLE
Han Zeng, Jiaxin Song, Yiyao Li, Chen Guo, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Xing Tang
The degradation of peptide drugs limits the application of peptide drug microspheres. Structural changes of peptides at the water-oil interface and the destruction of their spatial structure in the complex microenvironment during polymer degradation can affect drug release and in vivo biological activity. This study demonstrates that adding hydroxyethyl starch (HES) to the internal aqueous phase (W1 ) significantly enhances the stability of semaglutide and optimizes its release behavior in PLGA microspheres...
March 11, 2024: International Journal of Pharmaceutics
#36
JOURNAL ARTICLE
Islem Ouanes, Sarra Toumi, Yasser Ben Cheikh, Oussama Ben Rejeb, Nadia Mama
Hypereosinophilic syndrome (HES) is a leucoproliferative disorder, characterized by marked blood eosinophilia and organ damage due to tissue eosinophilia. Pulmonary involvement may lead to life-threatening acute respiratory failure and intensive care unit (ICU) admission. Association between eosinophilia and thromboembolism has been previously described. However, simultaneous venous and arterial thromboses are less reported. We report a case of a 25-year-old man, admitted to the ICU and developed acute respiratory failure, laboratory tests revealed hyperleukocytosis (39,700 /µL) with high eosinophil count (27393 /µl), Computed tomographic (CT) pulmonary angiography on admission showed a right pulmonary embolism and foci of splenic infarctions...
October 5, 2023: La Tunisie Médicale
#37
Mohamed Elbahoty, Sherine Elnaggar, Nooran Soror, Ahmed Elkeraie, Ayman Youssef
Hypereosinophilic syndrome (HES) is defined as the presence of (1) peripheral blood eosinophilia >1.5 x 109 /L for at least one month, (2) evidence of eosinophil-mediated organ damage and/or dysfunction, and (3) exclusion of other potential causes of eosinophilia. In hemodialysis patients, HES has been associated with manifestations because of low blood pressure or gastrointestinal symptoms that result in dialysis intolerance. Very few cases of HES co-occurrence in dialysis patients have been reported in the literature, and their clinical characteristics are not fully understood...
February 2024: Curēus
#38
JOURNAL ARTICLE
Tahania A Ahmad, Abu Zm Dayem Ullah, Claude Chelala, Dipesh P Gopal, Fabiola Eto, Rafael Henkin, Miriam Samuel, Sarah Finer, Stephanie Jc Taylor
Multimorbidity, the presence of a chronic condition in addition to cancer, is of particular importance to cancer survivors. It has an impact on the progression, stage at diagnosis, prognosis, and treatment of cancer patients. Evidence is scarce on the prevalence of specific comorbidities in survivors of different cancers to inform prevention and management of multimorbidity. The objective of this study is to address this evidence gap by using large scale electronic health data from multiple linked UK healthcare databases to examine the prevalence of multimorbidity in 28 cancer sites...
2024: American Journal of Cancer Research
#39
JOURNAL ARTICLE
Elham Ashrafi, Milica Radisic, Janet A W Elliott
H9c2 myoblasts are a cell line derived from embryonic rat heart tissue and demonstrate the ability to differentiate to cardiac myotubes upon reduction of the serum concentration (from 10% to 1%) and addition of all-trans retinoic acid in the growth medium. H9c2 cells are increasingly being used as an easy-to-culture proxy for some functions of cardiomyocytes. The cryobiology of cardiac cells including H9c2 myoblasts has not been studied as extensively as that of some cell types. Consequently, it is important to characterize the cryobiological response and systematically develop well-optimized cryopreservation protocols for H9c2 cells to have optimal and consistent viability and functionality after thaw for high quality studies with this cell type...
2024: PloS One
#40
JOURNAL ARTICLE
Yasuhiro Kajiwara, Yuichiro Honda, Ayumi Takahashi, Natsumi Tanaka, Hironobu Koseki, Junya Sakamoto, Minoru Okita
OBJECTIVES: This study aimed to determine whether mechanical stress via muscle contractile exercise with belt electrode-skeletal muscle electrical stimulation (B-SES) device effectively prevents immobilization-induced bone atrophy. METHODS: Wistar rats were randomly divided into the control (CON) group, immobilization (IM) group (immobilized treatment only), HES and LES groups (immobilized treatment and high or low-intensity electrical muscular stimulation through B-SES device)...
March 1, 2024: Journal of Musculoskeletal & Neuronal Interactions
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