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https://www.readbyqxmd.com/read/28338941/data-resource-profile-hospital-episode-statistics-admitted-patient-care-hes-apc
#1
Annie Herbert, Linda Wijlaars, Ania Zylbersztejn, David Cromwell, Pia Hardelid
No abstract text is available yet for this article.
March 15, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28337763/automatic-washing-of-thawed-haematopoietic-progenitor-cell-grafts-a-preclinical-evaluation
#2
M Abonnenc, B Pesse, J-D Tissot, S Barelli, N Lion
BACKGROUND AND OBJECTIVES: Autologous haematopoietic progenitor cell (HPC) is a prerequisite for high-dose chemotherapy in treatment of several haematologic and non-haematologic malignancies. HPCs are collected by apheresis and cryopreserved until infusion. Postinfusion adverse events have been in part related to the dimethyl sulphoxide (DMSO) used as cryoprotectant. The aim was to evaluate (i) an automated sequential washing procedure for DMSO removal in thawed HPC grafts and (ii) washing solutions in replacement of hydroxyethyl starch (HES)-based solutions...
March 23, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28337408/eosinophilic-granulomatosis-with-polyangiitis-formerly-known-as-churg-strauss-syndrome-as-a-differential-diagnosis-of-hypereosinophilic-syndromes
#3
Yuri Albuquerque Pessoa Santos, Bruno Rangel Antunes Silva, Pollyanna Natividade Zanconato Barros Assis Lira, Luiz Carlos Aguiar Vaz, Thiago Thomaz Mafort, Leonardo Palermo Bruno, Agnaldo José Lopes
Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome, is a rare systemic disease situated between primary small vessel vasculitides associated with antineutrophil cytoplasmic antibodies (ANCAs) and hypereosinophilic syndromes (HES). Here, we present a case of EGPA in a 38-year-old male, with a previous diagnosis of asthma, who presented with fever, migratory lung infiltrates and systemic eosinophilia that was refractory to previous courses of antibiotics. This case highlights the importance of the primary care physician understanding the differential diagnosis of pulmonary eosinophilic syndromes...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28331624/comparison-of-hydroxyethyl-starch-regulatory-summaries-from-the-food-and-drug-administration-and-the-european-medicines-agency
#4
Christian J Wiedermann, Klaus Eisendle
This article aims to highlight the positions of the Food and Drug Administration and the European Medicines Agency regarding use and marketing of hydroxyethyl starch (HES) products, and how these have changed over recent years. In 2013, warnings from both agencies advised against use of HES in critically ill patients, including patients with sepsis, when several large randomized controlled trials on volume resuscitation in critical illness failed to observe clinically beneficial effects of HES. In areas such as patient monitoring and requirements for further clinical trials, the FDA and EMA are very much in agreement in their recommendations...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/28325361/warthin-like-papillary-renal-cell-carcinoma-clinicopathologic-morphologic-immunohistochemical-and-molecular-genetic-analysis-of-11-cases
#5
Faruk Skenderi, Monika Ulamec, Tomas Vanecek, Petr Martinek, Reza Alaghehbandan, Maria Pane Foix, Iva Babankova, Delia Perez Montiel, Isabel Alvarado-Cabrero, Marian Svajdler, Pavol Dubinský, Dana Cempirkova, Michal Pavlovsky, Semir Vranic, Ondrej Daum, Ondrej Ondic, Kristyna Pivovarcikova, Kvetoslava Michalova, Milan Hora, Pavla Rotterova, Adela Stehlikova, Martin Dusek, Michal Michal, Ondrej Hes
Oncocytic papillary renal cell carcinoma (PRCC) is a distinct subtype of PRCC, listed as a possible new variant of PRCC in the 2016 WHO classification. It is composed of papillae aligned by large single-layered eosinophilic cells showing linearly arranged oncocytoma-like nuclei. We analyzed clinicopathologic, morphologic, immunohistochemical and molecular-genetic characteristics of 11 oncocytic PRCCs with prominent tumor lymphocytic infiltrate, morphologically resembling Warthin's tumor. The patients were predominantly males (8/11, 73%), with an average age of 59years (range 14-76), and a mean tumor size of 7cm (range 1-22cm)...
April 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28324043/reduced-transforming-growth-factor-beta-activity-in-the-endometrium-of-women-with-heavy-menstrual-bleeding
#6
J A Maybin, L Boswell, V J Young, W C Duncan, Hod Critchley
Context: Heavy menstrual bleeding (HMB) is common and incapacitating. Aberrant menstrual endometrial repair may result in HMB. The TGFβ superfamily contributes to tissue repair, but its role in HMB is unknown. Objective: We hypothesised that TGFβ1 is important for endometrial repair and women with HMB have aberrant TGFβ1 activity at menses. Participants/Setting: Endometrial biopsies were collected from women and menstrual blood loss objectively measured (HMB >80ml/cycle, normal menstrual bleeding, NMB <80ml)...
January 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28316062/cldn-1-promoted-the-epithelial-to-migration-and-mesenchymal-transition-emt-in-human-bronchial-epithelial-cells-via-notch-pathway
#7
Jing Lv, Baohua Sun, Zhitao Mai, Mingming Jiang, Junfeng Du
Claudin-1 (CLDN-1) is one of main tight junction components that play an important role in epithelial-mesenchymal transition (EMT). However, the effects of CLDN-1 on the migration and EMT induced by TGF-β1 in primary normal human bronchial epithelial (NHBE) and BEAS-2B cells have not been clear. The expression of CLDN-1 was quantified by Western blotting in NHBE and BEAS-2B cells. Cell migration and invasion were detected using transwell assays. The expression level of E-cadherin, N-cadherin, α-SMA, and Vimentin was evaluated by quantitative real-time PCR and Western blotting...
March 18, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28315424/diagnostic-criteria-for-oncocytic-renal-neoplasms-a-survey-of-urologic-pathologists
#8
Sean R Williamson, Ramya Gadde, Kiril Trpkov, Michelle S Hirsch, John R Srigley, Victor E Reuter, Liang Cheng, L Priya Kunju, Ravi Barod, Craig G Rogers, Brett Delahunt, Ondrej Hes, John N Eble, Ming Zhou, Jesse K McKenney, Guido Martignoni, Stewart Fleming, David J Grignon, Holger Moch, Nilesh S Gupta
Renal oncocytoma and chromophobe renal cell carcinoma (RCC) have been long recognized as distinct tumors; however, it remains unknown if uniform diagnostic criteria are used to distinguish these tumor types in practice. A survey was distributed to urologic pathologists regarding oncocytic tumors. Responses were received from 17/26 invitees. Histologically, >1 mitotic figure was regarded as most worrisome (n=10) or incompatible (n=6) with oncocytoma diagnosis. Interpretation of focal nuclear wrinkling, focal perinuclear clearing, and multinucleation depended on extent and did not necessarily exclude oncocytoma if minor...
March 14, 2017: Human Pathology
https://www.readbyqxmd.com/read/28302346/postoperative-acute-kidney-injury-and-blood-product-transfusion-after-synthetic-colloid-use-during-cardiac-surgery
#9
Rajika Tobey, Hao Cheng, Mei Gao, Zhongmin Li, J Nilas Young, W Douglas Boyd, Fuhai Ji, Hong Liu
OBJECTIVES: This study assessed the effect of 2 types of hydroxyethyl starches (HES) on renal integrity and blood transfusion in cardiac surgery patients. DESIGN: Retrospective investigation. SETTING: Patients from a single tertiary medical center. PARTICIPANTS: Inclusion criteria included coronary artery bypass graft (CABG) and/or valve surgery that included cardiopulmonary bypass with aortic cross-clamping. INTERVENTIONS: Intraoperative HES and blood product administration...
December 28, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28300872/impacts-of-albumin-synergized-with-hydroxyethyl-starch-on-early-microvascular-albumin-leakage-after-major-abdominal-surgery-in-rabbits
#10
Weiming Li, Pengyuan Xu, Yunyun Cen, Dali Sun, Ting Yang, Qingwen Xu, Shumin Li, Yijun Li, Bo Ding
PURPOSE: To investigate the impacts of albumin synergized with hydroxyethyl starch (HES) on early microvascular albumin leakage after major abdominal surgery in rabbits. METHODS: Forty male Japanese rabbits were randomly divided into four groups: the control group, the saline group, the albumin group, and the Syn group (hydroxyethyl starch+albumin). The latter three groups were performed gastrectomy plus resection of pancreatic body and tail and splenectomy. The serum albumin concentration was detected before and 48h after surgery, and the conditions of mesenteric microvascular leakage in these 4 groups were observed under microscope 48 h after surgery to calculate the leakage rate...
February 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28299746/improving-physical-activity-program-adoption-using-integrated-research-practice-partnerships-an-effectiveness-implementation-trial
#11
Samantha M Harden, Sallie Beth Johnson, Fabio A Almeida, Paul A Estabrooks
Integrated research-practice partnerships (IRPPs) may improve adoption of evidence-based programs. The aim of this study is to compare adoption of an IRPP-developed physical activity (PA) program (Fit Extension, FitEx) to a typical efficacy-effectiveness-dissemination pipeline model program (Active Living Every Day, ALED). Guided by the Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) framework, a randomized controlled trial assigned health educators (HEs) to FitEx (n = 18) or ALED (n = 18)...
March 2017: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/28299474/a-population-based-cohort-study-of-emergency-appendectomy-performed-in-england-and-new-york-state
#12
Waleed Al-Khyatt, Jemma Mytton, Benjamin H L Tan, Christopher T Aquina, Felicity Evison, Fergal J Fleming, Sandro Pasquali, Ewen A Griffiths, Ravinder S Vohra
BACKGROUND: To compare selected outcomes (30-day reoperation and total length of hospital stay) following emergency appendectomy between populations from New York State and England. METHODS: This retrospective cohort study used demographic and in-hospital outcome data from Hospital Episode Statistics (HES) and the New York Statewide Planning and Research Cooperative System (SPARCS) administrative databases for all patients aged 18+ years undergoing appendectomy between April 2009 and March 2014...
March 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28298021/prophylactic-nimodipine-treatment-and-improvement-in-hearing-outcome-after-vestibular-schwannoma-surgery-a-combined-analysis-of-a-randomized-multicenter-phase-iii-trial-and-its-pilot-study
#13
Christian Scheller, Andreas Wienke, Marcos Tatagiba, Alireza Gharabaghi, Kristofer F Ramina, Oliver Ganslandt, Barbara Bischoff, Johannes Zenk, Tobias Engelhorn, Cordula Matthies, Thomas Westermaier, Gregor Antoniadis, Maria Teresa Pedro, Veit Rohde, Kajetan von Eckardstein, Thomas Kretschmer, Malte Kornhuber, Jörg Steighardt, Michael Richter, Fred G Barker, Christian Strauss
OBJECT In clinical routines, neuroprotective strategies in neurosurgical interventions are still missing. A pilot study (n = 30) and an analogously performed Phase III trial (n = 112) pointed to a beneficial effect of prophylactic nimodipine and hydroxyethyl starch (HES) in vestibular schwannoma (VS) surgery. Considering the small sample size, the data from both studies were pooled. METHODS The patients in both investigator-initiated studies were assigned to 2 groups. The treatment group (n = 70) received parenteral nimodipine (1-2 mg/hour) and HES (hematocrit 30%-35%) from the day before surgery until the 7th postoperative day...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28293867/binding-specificity-of-r-10g-and-tra-1-60-81-and-substrate-specificity-of-keratanase-ii-studied-with-chemically-synthesized-oligosaccharides
#14
Hiromi Nakao, Yuko Nagai, Aya Kojima, Hidenao Toyoda, Nobuko Kawasaki, Toshisuke Kawasaki
Recently, we established a mouse monoclonal antibody specific to hiPS/ hES cells, R-10G, which recognizes a type of keratan sulfate. Keratan sulfates (KS) comprise a family of glycosaminoglycans consisting of the repeating unit of [Gal-GlcNAc(6S)]. However, there is a diversity in the degree of sulfation at Gal and GlcNAc residues, and also in the mode of linkage, Galβ1 - 3GlcNAc (type 1) or Galβ1 - 4GlcNAc (type 2). To gain more insight into the binding specificity of R-10G, we carried out an ELISA test on avidin-coated plates using polyethylene glycol (PEG)3-biotinylated derivatives of a series of N-acetyllactosamine tetrasaccharides (keratan sulfates (KSs))...
March 14, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28292748/unwarranted-variation-in-the-quality-of-care-for-patients-with-diseases-of-the-thoracic-aorta
#15
Alex Bottle, Giovanni Mariscalco, Matthew A Shaw, Umberto Benedetto, Athanasios Saratzis, Silvia Mariani, Mohamad Bashir, Paul Aylin, David Jenkins, Aung Y Oo, Gavin J Murphy
BACKGROUND: Thoracic aortic disease has a high mortality. We sought to establish the contribution of unwarranted variation in care to regional differences in outcomes observed in patients with thoracic aortic disease in England. METHODS AND RESULTS: Data from the Hospital Episode Statistics (HES) and the National Adult Cardiac Surgery Audit (NACSA) were extracted. A parallel systematic review/meta-analysis through December 2015, and structure and process questionnaire of English cardiac surgery units were also accomplished...
March 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28290180/non-bacterial-thrombotic-endocarditis-of-aortic-valve-due-to-hypereosinophilic-syndrome
#16
Harveen Lamba, Salil Deo, Salah Altarabsheh, Yakov Elgudin, Allen Markowitz, Soon Park
Hypereosinophilic syndrome (HES) is a rare hematological disorder, which may present with cardiac involvement. The case is presented of a 61-year-old male patient with isolated aortic stenosis secondary to non-bacterial thrombotic endocarditis and HES. The patient underwent successful aortic valve replacement with a bioprosthesis and remained recurrence-free at the 18-month follow up. A review of the current literature is also presented and cardiac manifestations, clinical presentation and surgical issues in the care of patients with this rare condition are discussed...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28290178/multiple-valvular-complications-of-hypereosinophilic-syndrome
#17
Zoltán Pozsonyi, Szabolcs Benedek, Pál Sármán, Lívia Jánoskuti, Tivadar Hüttl, Astrid Apor
Endomyocardial fibrosis (EMF) is the most common cardiac abnormality in hyeperosinophilic syndrome (HES), sometimes complicated with mitral valve disease. Mitral valve disease without ventricular manifestation is very rare, however. Case reports link HES to prosthetic valve thrombosis (PVT), but the optimal type of prosthetic valve in HES is not known. Herein is reported the case of a young female HES patient with secondary mitral valve degeneration and severe regurgitation. A mechanical prosthetic valve was implanted six months after she was diagnosed with HES, but despite anticoagulation and antiplatelet therapy she developed PVT three months later...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28288585/hypertonic-saline-attenuates-expression-of-notch-signaling-and-proinflammatory-mediators-in-activated-microglia-in-experimentally-induced-cerebral-ischemia-and-hypoxic-bv-2-microglia
#18
Wen-Xin Zeng, Yong-Li Han, Gao-Feng Zhu, Lin-Qiang Huang, Yi-Yu Deng, Qiao-Sheng Wang, Wen-Qiang Jiang, Miao-Yun Wen, Qian-Peng Han, Di Xie, Hong-Ke Zeng
BACKGROUND: Ischemic stroke is a major disease that threatens human health in ageing population. Increasing evidence has shown that neuroinflammatory mediators play crucial roles in the pathophysiology of cerebral ischemia injury. Notch signaling is recognized as the cell fate signaling but recent evidence indicates that it may be involved in the inflammatory response in activated microglia in cerebral ischemia. Previous report in our group demonstrated hypertonic saline (HS) could reduce the release of interleukin-1 beta and tumor necrosis factor-alpha in activated microglia, but the underlying molecular and cellular mechanisms have remained uncertain...
March 14, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28283219/pet-mri-multiparametric-imaging-of-brain-tumors
#19
Jiří Ferda, Eva Ferdová, Ondřej Hes, Jan Mraček, Boris Kreuzberg, Jan Baxa
A combination of morphological imaging of the brain with microstructural and functional imaging provides a comprehensive overview of the properties of individual tissues. While diffusion weighted imaging provides information about tissue cellularity, spectroscopic imaging allows us to evaluate the integrity of neurons and possible anaerobic glycolysis during tumor hypoxia, in addition to the presence of accelerated synthesis or degradation of cellular membranes; on the other hand, PET metabolic imaging is used to evaluate major metabolic pathways, determining the overall extent of the tumor ((18)F-FET, (18)F-FDOPA, (18)F-FCH) or the degree of differentiation ((18)F-FDG, (18)F-FLT, (18)F-FDOPA and (18)F-FET)...
February 22, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28272837/the-effect-of-buckwheat-hull-extract-on-lipid-oxidation-in-frozen-stored-meat-products
#20
Marzanna Hęś, Artur Szwengiel, Krzysztof Dziedzic, Joanna Le Thanh-Blicharz, Dominik Kmiecik, Danuta Górecka
This study investigated the effect of antioxidants on lipid stability of frozen-stored meat products. Buckwheat hull extract was used to enrich fried meatballs made from ground pork. During 180-d storage of meat products, lipid oxidation (peroxide and 2-thiobarbituric acid reactive substances [TBARS] value) was periodically monitored. The results were compared with butylated hydroxytoluene (BHT). The addition of antioxidants decreased lipid oxidation in stored meatballs. The highest ability to control peroxide and TBARS values was demonstrated for buckwheat hull extract...
March 8, 2017: Journal of Food Science
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