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https://www.readbyqxmd.com/read/29779281/-effects-of-tumor-necrosis-factor-%C3%AE-on-osteogenic-differentiation-and-notch-signaling-pathway-in-human-periodontal-ligament-stem-cells
#1
Yu Ma, Shu-Hui Li, Xin-Xin Ding, Pei-Ling Wu
OBJECTIVE: To evaluate the effects of tumor necrosis factor-α (TNF-α) on osteogenic differentiation and Notch signaling pathway of periodontal ligament stem cells (PDLSCs) and to investigate the regulatory role of Notch signaling pathway on the osteogenic differentiation of PDLSCs under the influence of TNF-α. METHODS: PDLSCs were obtained through enzyme digestion and tissue block method. The expression levels of stem cell surface markers CD105, CD90, CD146, CD45, and CD31 were detected by fluorescence activated cell sorter (FACS)...
April 1, 2018: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29777207/clinical-progression-and-metachronous-paragangliomas-in-a-large-cohort-of-sdhd-germline-variant-carriers
#2
Berdine L Heesterman, Lisa M H de Pont, Andel Gl van der Mey, Jean-Pierre Bayley, Eleonora Pm Corssmit, Frederik J Hes, Berit M Verbist, Peter Paul G van Benthem, Jeroen C Jansen
Although it is well established that paternally transmitted germline variants in SDHD are associated with multifocal paragangliomas and lifelong follow-up is generally advised, the risk of metachronous lesions is presently unknown. In a large Dutch cohort of SDHD variant carriers, we studied the development of new paragangliomas, and the evolution of symptoms and cranial nerve impairment. Recurrent event analysis and the Kaplan-Meier product limit estimator were used to study the risk of new lesions. The relation between several predictors and development of new symptoms was assessed using logistic regression...
May 18, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29758550/microrna-449a-inhibition-protects-h9c2-cells-against-hypoxia-reoxygenation-induced-injury-by-targeting-the-notch-1-signaling-pathway
#3
Jing Cheng, Qianfu Wu, Rong Lv, Li Huang, Banglong Xu, Xianbao Wang, Aihua Chen, Fei He
BACKGROUND/AIMS: The present study aimed to detect the expression of miR-449a and investigate the effect of miR-449a on cell injury in cardiomyocytes subjected to hypoxia/ reoxygenation (H/R) and its underlying mechanisms. METHODS: The expression of miR-449a was determined using reverse transcription-polymerase chain reaction in both neonatal rat ventricular myocytes and H9C2 cells. For gain-of-function and loss-of-function studies, H9C2 cells were transfected with either miR-449a mimics or miR-449a inhibitor...
May 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29758216/molecular-background-of-colorectal-tumors-from-patients-with-lynch-syndrome-associated-with-germline-variants-in-pms2
#4
S W Ten Broeke, T C van Bavel, A M L Jansen, E Gómez-García, F J Hes, L P van Hest, T G W Letteboer, M J W Olderode-Berends, D Ruano, L Spruijt, M Suerink, C M Tops, R van Eijk, H Morreau, T van Wezel, M Nielsen
BACKGROUND & AIMS: Germline variants in the mismatch repair genes MLH1, MSH2 (EPCAM), MSH6, or PMS2 cause Lynch syndrome. Patients with these variants have an increased risk of developing colorectal cancers (CRCs) that differ from sporadic CRCs in genetic and histologic features. It has been a challenge to study CRCs associated with PMS2 variants (PMS2-associated CRCs) because these develop less frequently and in patients of older ages than colorectal tumors with variants in the other mismatch repair genes...
May 11, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29751154/long-term-clinical-outcomes-of-high-dose-mepolizumab-treatment-for-hypereosinophilic-syndrome
#5
Fei Li Kuang, Michael P Fay, JeanAnne Ware, Lauren Wetzler, Nicole Holland-Thomas, Thomas Brown, Hector Ortega, Jonathan Steinfeld, Paneez Khoury, Amy D Klion
BACKGROUND: Conventional therapies for hypereosinophilic syndromes (HES) have variable efficacy and carry significant long-term toxicities. Anti-IL5 (mepolizumab) therapy has a glucocorticoid (GC)-sparing effect in GC-sensitive HES, but the efficacy of mepolizumab in treatment-refractory HES patients with severe disease has not been examined to date. OBJECTIVE: To identify predictors of response to mepolizumab in subjects with severe treatment-refractory HES and compare long-term outcomes in these subjects to HES subjects treated with conventional therapies...
May 8, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29750292/microrna%C3%A2-381-hes1-is-a-potential-therapeutic-target-for-spinal-cord-injury
#6
Wendong Ruan, Guangzhi Ning, Shiqing Feng, Shijie Gao, Yan Hao
The aim of the present study was to investigate whether microRNA‑381 is a potential therapeutic target for spinal cord injury (SCI) and its possible mechanism. Reverse transcription quantitative polymerase chain reaction (qPCR) for mRNA expression was used to analyze the changes of microRNA-381 expression. Cell viability and cell apoptosis were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry. Caspase‑3 activity was measured using caspase‑3 activity kit, and western blot analysis was used to measure the protein expression of neurogenic locus notch homolog protein 1 (Notch1), notch 1 intracellular domain (NICD) and transcription factor HES-1 (Hes1)...
May 8, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29743461/-determination-of-hesperidin-and-monoglucosylhesperidin-contents-in-processed-foods-using-relative-molar-sensitivity-based-on-1-h-quantitative-nmr
#7
Yuzo Nishizaki, Naoko Sato-Masumoto, Akihito Nakanishi, Yushi Hashizume, Mahamadou Tandia, Taichi Yamazaki, Miho Kuroe, Masahiko Numata, Toshihide Ihara, Naoki Sugimoto, Kyoko Sato
We designed an off-line combination of HPLC/photodiode array detector (PDA) and 1 H-quantitative NMR (1 H-qNMR) to estimate the relative molar sensitivity (RMS) of an analyte to a reference standard. The RMS is calculated as follows: a mixture of the analyte and the reference is analyzed using 1 H-qNMR and HPLC/PDA. The response ratio of the analyte and the reference obtained by HPLC/PDA is then corrected using the molar ratio obtained by 1 H-qNMR. We selected methylparaben (MPB), which is a certified reference material, as the reference standard and hesperidin (Hes) and monoglucosylhesperidin (MGHes) as analytes, and the RMSs of Hes283 nm /MPB255 nm and MGHes283 nm /MPB255 nm were determined as 1...
2018: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/29739754/dexpramipexole-as-an-oral-steroid-sparing-agent-in-hypereosinophilic-syndromes
#8
Sandhya R Panch, Michael E Bozik, Thomas Brown, Michelle Makiya, Calman Prussin, Donald G Archibald, Gregory T Hebrank, Mary Sullivan, Xiaoping Sun, Lauren Wetzler, JeanAnne Ware, Michael P Fay, Cynthia E Dunbar, Steven I Dworetzky, Paneez Khoury, Irina Maric, Amy D Klion
Hypereosinophilic syndromes (HES) are a heterogeneous group of disorders characterized by peripheral eosinophilia and eosinophil-related end organ damage. Whereas most patients respond to glucocorticoid (GC) therapy, high doses are often necessary and side effects are common. Dexpramipexole (KNS 760704), an orally bioavailable synthetic amino-benzothiazole, showed an excellent safety profile and was coincidentally noted to significantly decrease absolute eosinophil counts (AEC) in a phase 3 trial for amyotrophic lateral sclerosis...
May 8, 2018: Blood
https://www.readbyqxmd.com/read/29730458/annular-closure-in-lumbar-microdiskectomy-for-prevention-of-reherniation-a-randomized-clinical-trial
#9
Claudius Thomé, Peter Douglas Klassen, Gerrit J Bouma, Adisa Kursumovic, Javier Fandino, Martin Barth, Mark Arts, Wimar van den Brink, Richard Bostelmann, Aldemar Hegewald, Volkmar Heidecke, Peter Vajkoczy, Susanne Fröhlich, Jasper Wolfs, Richard Assaker, Erik Van de Kelft, Hans-Peter Köhler, Senol Jadik, Sandro Eustacchio, Robert Hes, Frederic Martens
BACKGROUND CONTEXT: Patients with large annular defects following lumbar diskectomy for disk herniation are at high risk for symptomatic recurrence and reoperation. PURPOSE: To determine whether a bone-anchored annular closure device in addition to lumbar microdiskectomy resulted in lower reherniation and reoperation rates plus increased overall success compared to lumbar microdiskectomy alone. DESIGN: Multicenter, randomized superiority study...
May 3, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29728805/large-volume-crystalloid-fluid-is-associated-with-increased-hyaluronan-shedding-and-inflammation-in-a-canine-hemorrhagic-shock-model
#10
Lisa Smart, C J Boyd, M A Claus, E Bosio, G Hosgood, A Raisis
Shedding of the endothelial glycocalyx precedes leukocyte activation and adherence in acute inflammation. Rapid administration of crystalloid or colloid fluids for treating hemorrhagic shock may cause endothelial glycocalyx shedding, thereby increasing inflammation. This study aimed to compare the effect of different fluid treatments in a canine shock model on glycocalyx biomarker, hyaluronan, and inflammatory biomarkers. Greyhound dogs under general anesthesia subject to hemorrhage for 60 min were given 20 mL kg-1 of either fresh whole blood (FWB), hydroxyethyl starch (HES) 130/0...
May 4, 2018: Inflammation
https://www.readbyqxmd.com/read/29728756/postoperative-renal-function-in-parturients-with-severe-preeclampsia-who-underwent-cesarean-delivery-a-retrospective-observational-study
#11
Yusuke Mazda, Motoshi Tanaka, Katsuo Terui, Sayuri Nagashima, Rie Inoue
Although postoperative renal dysfunction is relatively rare after cesarean delivery, preeclampsia is considered as the high-risk population. On the other hand, hydroxyethyl starch (HES) administration for preventing maternal hypotension induced by spinal anesthesia for cesarean delivery is a common practice. However, the effect of HES administration during cesarean delivery on postoperative kidney function in parturients with severe preeclampsia is not well investigated. We retrospectively reviewed both medical and anesthesia records of patients with severe preeclampsia who underwent cesarean delivery from January 2011 to December 2013...
May 4, 2018: Journal of Anesthesia
https://www.readbyqxmd.com/read/29720422/gremlin-activates-the-notch-pathway-linked-to-renal-inflammation
#12
Carolina Lavoz, Jonay Poveda, Laura Márquez-Expósito, Sandra Rayego-Mateos, Raul R Rodrigues-Diez, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Marta Ruiz-Ortega
Preclinical studies suggest that Gremlin participates in renal damage and could be a potential therapeutic target for human chronic kidney diseases. Inflammation is a common characteristic of progressive renal disease, and therefore novel anti-inflammatory therapeutic targets should be investigated. The Notch signaling pathway is involved in kidney development and is activated in human chronic kidney disease, but whether Gremlin regulates the Notch pathway has not been investigated. In cultured tubular cells, Gremlin up-regulated gene expression of several Notch pathway components, increased the production of the canonical ligand Jagged-1 and caused the nuclear translocation of active Notch-1 (N1ICD)...
May 2, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29716625/6-hydroxyethyl-starch-hes-130-0-4-diminishes-glycocalyx-degradation-and-decreases-vascular-permeability-during-systemic-and-pulmonary-inflammation-in-mice
#13
Andreas Margraf, Jan M Herter, Katharina Kühne, Anika Stadtmann, Thomas Ermert, Manuel Wenk, Melanie Meersch, Hugo Van Aken, Alexander Zarbock, Jan Rossaint
BACKGROUND: Increased vascular permeability is a pathophysiological hallmark of sepsis and results in increased transcapillary leakage of plasma fluid, hypovolemia, and interstitial edema formation. 6% hydroxyethyl starch (HES 130/0.4) is commonly used to treat hypovolemia to maintain adequate organ perfusion and oxygen delivery. The present study was designed to investigate the effects of 6% HES 130/0.4 on glycocalyx integrity and vascular permeability in lipopolysaccharide (LPS)-induced pulmonary inflammation and systemic inflammation in mice...
May 1, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29714651/hypereosinophilic-syndrome-preceding-a-diagnosis-of-b-cell-lymphoma
#14
Arash Samarghandi, Shradha Ahuja, Vishal Jindal, Sorab Gupta, Ilmana Fulger
INTRODUCTION: Hypereosinophilic syndrome (HES) is a rare condition characterized by eosinophilia and organ destruction secondary to eosinophilic infiltration. The coexistence of primary B-cell lymphoma and hypereosinophilic syndrome is extremely rare. We present a case of HES that preceded the diagnosis of diffuse large B-cell lymphoma. CASE REPORT: A 70-year-old man presented with a 3-month history of diarrhea and 30-pound weight loss. Complete blood count showed a white blood cell count of 7452/µL with eosinophils of 42% (absolute eosinophil count 3130)...
March 1, 2018: Tumori
https://www.readbyqxmd.com/read/29706640/rna-analysis-of-cancer-predisposing-genes-in-formalin-fixed-paraffin-embedded-tissue-determines-aberrant-splicing
#15
Anne Ml Jansen, Heleen M van der Klift, Marieke Ae Roos, Jaap Dh van Eendenburg, Carli Mj Tops, Juul T Wijnen, Frederik J Hes, Hans Morreau, Tom van Wezel
High-throughput sequencing efforts in molecular tumour diagnostics detect increasing numbers of novel variants, including variants predicted to affect splicing. In silico prediction tools can reliably predict the effect of variant disrupting canonical splice sites; however, experimental validation is required to confirm aberrant splicing. Here, we present RNA analysis performed for 13 canonical splice site variants predicted or known to result in splicing in the cancer predisposition genes MLH1, MSH2, MSH6, APC and BRCA1...
April 30, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29706108/the-use-of-a-simultaneous-integrated-boost-in-spinal-stereotactic-body-radiotherapy-to-reduce-the-risk-of-vertebral-compression-fractures-a-treatment-planning-study
#16
Joanne M van der Velden, Jochem Hes, Arjun Sahgal, Stan J Hoogcarspel, Marielle E P Philippens, Wietse S C Eppinga, Enrica Seravalli
No abstract text is available yet for this article.
April 28, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29705715/solid-pseudopapillary-neoplasm-spn-of-the-testis-comprehensive-mutational-analysis-of-6-testicular-and-8-pancreatic-spns
#17
Kvetoslava Michalova, Michael Michal, Monika Sedivcova, Dmitry V Kazakov, Carlos Bacchi, Tatjana Antic, Marketa Miesbauerova, Ondrej Hes, Michal Michal
BACKGROUND: Recently, we came with the theory of a possible relationship between a group of testicular and pancreatic tumors. We used one case of a pancreatic analogue solid pseudopapillary neoplasm of the testis composed partially of areas reminiscent of solid pseudopapillary neoplasm (SPN) of the pancreas and partially of structures identical to primary signet ring stromal tumor of the testis (PSRSTT) as a connecting link between these two entities. After demonstrating that PSRSTT and pancreatic analogue SPN of the testis share the same immunoprofile and genetic features characteristic for pancreatic SPN, we came to the conclusion that pancreatic analogue SPN of the testis and PSRSTT represent a morphological spectrum of a single entity and that both are related to the pancreatic SPN...
April 20, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29703051/balanced-10-hydroxyethyl-starch-compared-with-balanced-6-hydroxyethyl-starch-and-balanced-crystalloid-using-a-goal-directed-hemodynamic-algorithm-in-pancreatic-surgery-a-randomized-clinical-trial
#18
Julia Werner, Oliver Hunsicker, Anja Schneider, Henryk Stein, Christian von Heymann, Adrian Freitag, Aarne Feldheiser, Klaus-Dieter Wernecke, Claudia Spies
BACKGROUND: While hydroxyethyl starch (HES) solutions are not recommended any longer in critically ill patients, data on efficacy and safety during surgery are still limited. METHODS: In a randomized controlled trial 63 patients were assigned to receive 10% HES (130/0.42), 6% HES (130/0.42), or crystalloid within a goal-directed hemodynamic algorithm during pancreatic surgery. The primary endpoints were intraoperative volume of HES and time until fully on oral diet...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29694990/respiratory-instability-and-hypoxemia-episodes-in-preterm-infants
#19
Eduardo Bancalari, Nelson Claure
Oxygenation instability is a very common problem in the premature infant that manifests as intermittent hypoxemia episodes (HEs). These are particularly frequent in premature infants who are on mechanical ventilation beyond the first weeks after birth. However, they can also occur in spontaneously breathing infants. Some of these episodes are due to central apnea, but in ventilated infants, they are frequently due to contractions of the abdominal musculature that can splint the respiratory pump, resulting in periods of decreased lung volume and hypoventilation...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29692610/preparation-characterization-and-systemic-application-of-self-assembled-hydroxyethyl-starch-nanoparticles-loaded-flavonoid-morin-for-hyperuricemia-therapy
#20
Jianbo Li, Yang Yang, Likang Lu, Qiujin Ma, Jinjie Zhang
Background: Morin, one of the most widely distributed flavonoids in plants, has been identified as a potent antihyperuricemic agent. Its poor water solubility and fast in vivo clearance, however, have limited its application in the treatment of hyperuricemia. In this study, a novel amphiphilic polymer (hydroxyethyl starch-deoxycholic acid [HES-DOCA]) was synthesized to overcome these limitations. Methods: HES-DOCA conjugates with various substitution degrees were prepared by chemical grafting DOCA to HES through ester formation...
2018: International Journal of Nanomedicine
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