Fiona Sewell, Camilla Alexander-White, Susy Brescia, Richard A Currie, Ruth Roberts, Clive Roper, Catherine Vickers, Carl Westmoreland, Ian Kimber
New approach methodologies (NAMs) can deliver improved chemical safety assessment through the provision of more protective and/or relevant models that have a reduced reliance on animals. Despite the widely acknowledged benefits offered by NAMs, there continue to be barriers that prevent or limit their application for decision-making in chemical safety assessment. These include barriers related to real and perceived scientific, technical, legislative and economic issues, as well as cultural and societal obstacles that may relate to inertia, familiarity, and comfort with established methods, and perceptions around regulatory expectations and acceptance...
April 2024: Toxicology Research