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Tumor vascular normalization

Domenico Policicchio, Artan Doda, Enrico Sgaramella, Stefano Ticca, Filippo Veneziani Santonio, Riccardo Boccaletti
BACKGROUND: The use of intraoperative ultrasound (iUS) has increased in the last 15 years becoming a standard tool in many neurosurgical centers. Our aim was to assess the utility of routine use of iUS during various types of intracranial surgery. We reviewed our series to assess ultrasound visibility of different pathologies and iUS applications during the course of surgery. MATERIALS AND METHODS: This is a retrospective review of 162 patients who underwent intracranial surgery with assistance of the iUS guidance system (SonoWand)...
April 19, 2018: Acta Neurochirurgica
Li-Qian Liu, Fu-Jun Tian, Ying Xiong, Yan Zhao, Jian-Bo Song
Skin squamous cell carcinoma (SCC) is generally considered as nonaggressive lesions and mainly caused by ultraviolet (UV) radiation. Gadd45a is a key component protecting skin against UV-induced tumors. For that, the study aims to investigate the mechanism of Gadd45a gene silencing on cell proliferation, apoptosis, and senescence in nude mice with skin SCC through the p53 signaling pathway. Healthy nude mice was collected as the normal group and 40 nude mouse models of skin SCC were successfully established as the model group, which were sub-divided into five groups...
April 16, 2018: Journal of Cellular Physiology
Daishi Yamakawa, Weizhen Jia, Hiroyasu Kidoya, Shoko Hosojima, Miku Torigata, Li Zhang, Nobuyuki Takakura
Vascular endothelial cells (ECs) isolated from tumors characteristically express certain genes. It has recently been suggested that tumor vessel normalization facilitates effective drug delivery into tumors; however, how tumor vessel normalization can be recognized on the basis of the molecules expressed by tumor ECs is not clearly defined. The degree of cell proliferation is an important indicator to characterize the condition of the ECs. Herein, we generated transgenic mice expressing enhanced green fluorescent protein (EGFP) under the transcriptional control of the DNA replication factor partner of Sld5-1 (PSF1; official name GINS1) promoter to assess whether active ECs can be distinguished from dormant ECs...
April 2, 2018: American Journal of Pathology
Zhenhai Fan, Hongwei Xia, Huanji Xu, Ji Ma, Sheng Zhou, Wanting Hou, Qiulin Tang, Qiyong Gong, Yongzhan Nie, Feng Bi
High expression levels of CD44 and YAP have been identified as poor prognostic factors in hepatocellular carcinoma (HCC). However, the mechanistic relationship between CD44 and YAP during HCC tumorigenesis remains largely unknown. To investigate the mutual regulation between standard CD44 (CD44S) and YAP1 in HCC cell lines and tissue samples, CD44S and YAP1 expression in 40 pairs of tumor samples and matched distal normal tissues from HCC patients was examined by immunohistochemical staining. High expression of either CD44S or YAP1 was associated with a younger age and worse pathology grade...
April 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sudarat Onsurathum, Ornuma Haonon, Porntip Pinlaor, Chawalit Pairojkul, Narong Khuntikeo, Raynoo Thanan, Sittiruk Roytrakul, Somchai Pinlaor
Tumor interstitial fluid contains tumor-specific proteins that may be useful biomarkers for cancers. In this study, we identified proteins present in cholangiocarcinoma interstitial fluid. Proteins derived from three samples of tumor interstitial fluid and paired samples of adjacent normal interstitial fluid from cholangiocarcinoma patients were subjected to two-dimensional liquid chromatography with tandem mass spectrometry. Candidate proteins were selected based on a greater than twofold change in expression levels between tumor interstitial fluid and normal interstitial fluid...
April 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Min Gao, Jinhua Tang, Kun Liu, Ming Yang, Haiyun Liu
Purpose: We investigated the application of contrast-enhanced ultrasound (CEUS) to quantify vascular perfusion in two animal models of choroidal melanoma. Methods: B16F10 and choroidal melanoma cell line (OCM1) melanoma xenografts were implanted into the cyclodialysis cleft of rabbits' right eyes. Fundus photography, indocyanine green angiography (ICGA), B-mode ultrasound, and CEUS were used to examine the tumors. Standard vascular parameters of CEUS imaging were evaluated, including the area under the receiver operating characteristic curve (AUC), peak intensity (IMAX), mean transit time (mTT), rise time, and time to peak...
March 1, 2018: Investigative Ophthalmology & Visual Science
Zhiwei Hu, Rulong Shen, Amanda Campbell, Elizabeth L McMichael, Lianbo Yu, Bhuvaneswari Ramaswamy, Cheryl A London, Tian Xu, William E Carson
Triple-negative breast cancer (TNBC) is a leading cause of breast cancer death and is often associated with BRCA1 and BRCA2 mutation. Due to the lack of validated target molecules, no targeted therapy for TNBC is approved. Tissue factor (TF) is a common yet specific surface target receptor for cancer cells, tumor vascular endothelial cells and cancer stem cells in several types of solid cancers including breast cancer. Here we report evidence supporting the idea that TF is a surface target in TNBC. We used in vitro cancer lines and in vivo tumor xenografts in mice, all with BRCA1 or BRCA2 mutations, derived from patients' tumors...
April 5, 2018: Cancer Immunology Research
Hui-Yu Wei, Ya-Jie Zhang, Shao-Zhen Zhao
Neovascular glaucoma is an ophthalmic disease and a potentially blinding secondary glaucoma caused by the formation of abnormal new blood vessels on the iris, which can prevent the normal drainage of water from the anterior segment of the eye. Evidence from China has suggested that puerarin benefits many diseases including myocardial infarction, stable angina, cerebral ischemia and glaucoma in a clinical setting. In the present study, the aim was to investigate the efficacies of puerarin on neovascular glaucoma in a mouse model...
March 28, 2018: Molecular Medicine Reports
Cen Wen, Mengyuan Xu, Cheng Mo, Zhigang Cheng, Qulian Guo, Xiaoyan Zhu
Treatment of neuropathic pain (NPP) continues to be a major challenge, and the underlying mechanisms remain to be elucidated. Previous studies have demonstrated that histone methylation is important in synaptic plasticity of the nervous system and may affect nuclear factor‑κB (NF‑κB) signaling through epigenetic mechanisms. The present study aimed to investigate the role of Jumonji C domain 6 (JMJD6), a histone demethylase, in a chronic constriction injury (CCI) model of NPP. On the third day post‑CCI surgery, a JMJD6 overexpressing lentiviral vector (LV‑JMJD6) was intrathecally injected in the rats...
April 3, 2018: International Journal of Molecular Medicine
Xilong Wang, Jun Zhang, Yangyun Wang, Minqi Tu, Ying Wang, Guowei Shi
Purpose: As a typical hypervascular tumor, clear cell renal cell carcinoma (ccRCC) is the most common type of RCC. This study was aimed to explore the prognostic genes for ccRCC, focusing on the roles of vascular endothelial growth factor A ( VEGFA ) and Delta-like ligand 4 ( DLL4 ) in the disease. Materials and methods: The mRNA-sequencing data of kidney renal clear cell carcinoma (KIRC) were obtained from The Cancer Genome Atlas (TCGA) database, including 469 tumor samples and 68 adjacent normal samples...
2018: OncoTargets and Therapy
Rukiye Aydin, Tongalp H Tezel
PURPOSE: To report the efficacy of intravitreal bevacizumab to resolve secondary angle closure glaucoma caused by biliary tract carcinoma metastasis to iris. ABSTRACT: A 52-year-old Caucasian woman who was under systemic chemotherapy for biliary tract carcinoma presented with metastatic tumor in the left iris. At presentation, her visual acuity was at 20/50 level. Tumor was occupying nasal half of the iris and had already occupied 5.5 clock hours of the angle resulting intraocular pressure elevation to 34▒mm Hg...
April 2, 2018: Journal of Glaucoma
Lihua Zhong, Yuanyuan Wang, Yu Cheng, Wen Wang, Baoling Lu, Liying Zhu, Yingji Ma
In the recent years, increasing evidences identify circular RNAs (circRNAs) as a class of important regulators in various human cancers. Nevertheless, the functions and mechanisms of most circRNAs in cancer cells remain largely unknown. In this study, we found out a significantly downregulated circRNA circC3P1 in hepatocellular carcinoma (HCC) tissues compared to adjacent normal tissues. And our results indicated that circC3P1 expression level was negatively correlated with TNM stage, tumor size and vascular invasion in HCC...
April 3, 2018: Biochemical and Biophysical Research Communications
Bo He, Arnaud Jabouille, Veronica Steri, Anna Johansson-Percival, Iacovos P Michael, Venkata Ramana Kotamraju, Reimar Junckerstorff, Anna K Nowak, Juliana Hamzah, Gabriel Lee, Gabriele Bergers, Ruth Ganss
High grade brain cancer such as glioblastoma (GBM) remains an incurable disease. A common feature of GBM is the angiogenic vasculature which can be targeted with selected peptides for payload delivery. We assessed the ability of micelle-tagged, vascular homing peptides RGR, CGKRK or NGR to specifically bind to blood vessels in syngeneic orthotopic GBM models. By using the peptide CGKRK to deliver the TNF superfamily member LIGHT (also known as tumor necrosis factor superfamily member 14; TNFSF14) to angiogenic tumour vessels we have generated a reagent which normalizes the brain cancer vasculature by inducing pericyte contractility and re-establishing endothelial barrier integrity...
March 30, 2018: Journal of Pathology
Takamichi Katsuhara, Nobuhiro Moro, Takashi Ohta, Taku Homma, Atsuo Yoshino
Solitary primary intracranial leptomeningeal glioma (PLG) is a rare entity of glioma. PLG arises from the heterotopic glial tissue in the subarachnoid space and usually grows there without parenchymal invasion. The present study reported a case of solitary PLG, pathologically diagnosed as glioblastoma, that invaded the temporal cortex and finally disseminated to the spinal cord. A 55-year-old woman had headaches and visited Nihon University, Itabashi Hospital. Head magnetic resonance imaging showed a solid mass mainly located in the right middle fossa extending to the frontal base with strong enhancement effect after contrast medium injection...
March 2018: Molecular and Clinical Oncology
Debora Claramunt-Taberner, Aurélia Bertholet-Thomas, Marie-Christine Carlier, Frédérique Dijoud, Franck Chotel, Caroline Silve, Justine Bacchetta
BACKGROUND: Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare autosomal recessive disease caused by mutations in genes encoding FGF23 or its regulators, and leading to functional deficiency or resistance to fibroblast growth factor 23 (FGF23). Subsequent biochemical features include hyperphosphatemia due to increased renal phosphate reabsorption, and increased or inappropriately normal 1,25-dihydroxyvitamin D (1,25-D) levels. CASE-DIAGNOSIS/TREATMENT: A 15-year-old girl was referred for a 1...
March 28, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Michael R Chicoine
Introduction  A variety of dural openings are described for frontal-temporal and cranio-orbital craniotomies. As with any surgical technique, the goal is to optimally and safely address the pathology, minimize normal anatomy disruption, and optimize postoperative recovery. This study reports a modified dural opening for frontal-temporal approaches which minimizes brain exposure while facilitating visualization for neoplastic and vascular lesions of the anterior clinoid, supra- and parasellar and adjacent regions...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
Christopher S Rabender, Ninu Bruno, Asim Alam, Gobalakrishnan Sundaresan, Jamal Zweit, Ross B Mikkelsen
Previously we demonstrated that nitric oxide synthase (NOS) is uncoupled in a wide range of solid tumors and that restoring NOS coupling with the tetrahydrobiopterin precursor, sepiapterin (SP), inhibits tumor progression. Endothelial dysfunction characterizes the poorly functional vasculature of solid tumors and since NO is critical for regulation of endothelial function we asked whether SP, by recoupling NOS, improves tumor vasculature structure and function enhancing chemotherapeutic delivery and response to radiotherapy...
March 26, 2018: Journal of Pharmacology and Experimental Therapeutics
Vinayak Narayan, Nasser Mohammed, Shyamal C Bir, Amey R Savardekar, Devi Prasad Patra, Papireddy Bollam, Anil Nanda
INTRODUCTION: Stereotactic radiosurgery [SRS], particularly Gamma knife radiosurgery [GKRS] is an established treatment option for residual and recurrent pituitary adenoma tumors. It helps in the preservation of surrounding normal neuronal, vascular and hormone producing structures and cause less neurological deficits. The aim of the research is to evaluate the efficacy and define the role of GKRS for the treatment of non-functioning [NFA] and hormonal-active [HAA] pituitary adenoma. METHODS: A retrospective analysis of 111 patients of histologically proven pituitary adenoma who underwent GKRS treatment at LSU Health Sciences Center, Shreveport, Louisiana, USA over seventeen year period is presented...
March 21, 2018: World Neurosurgery
Yun Liu, Hai-Qi Liu, Jian-Ying Xiao, Kai-Ting Ma, Xin-Qiu-Yue Wang, Huan-Jia Shen, Jian-Dong Luo
Apoptosis plays a critical role in normal embryonic development and tissue homeostasis regulation. EndophilinA2 (EndoA2) is widely reported to regulate endocytosis. Additionally, EndoA2 has been demonstrated to be involved in tumor metastasis, neuroregulation and vascular function. In this study, we used siRNA and Ad-EndoA2 transfection strategy to investigate whether EndoA2 provides a protective effect against apoptosis induced by H2 O2 in H9C2 cardiomyocytes and the underlying mechanisms. We found that EndoA2 siRNA knockdown promoted H2 O2 -induced apoptosis in H9C2 cardiomyocytes, evidenced by decreased cell number, increased apoptotic cells, and activation of caspase-3...
March 23, 2018: Biochemical and Biophysical Research Communications
Byoung Kwan Son, Dong-Hoon Kim, Kyueng-Whan Min, Eun-Kyung Kim, Mi Jung Kwon
Gastric cancer is a heterogeneous disorder for which predicting clinical outcomes is challenging, although various biomarkers have been suggested. The Smad4 and Fascin proteins are known prognostic indicators of different types of malignancy. Smad4 primarily functions as a key regulator of tumor suppression, whereas Fascin exhibits oncogenic function by enhancing tumor infiltration. A combined marker based on these opposing roles may improve prognostic accuracy in gastric cancer. Smad4 and Fascin expression was assessed in tissue microarrays obtained from 285 primary gastric adenocarcinoma, 201 normal tissue, and 51 metastatic adenocarcinoma samples...
March 15, 2018: Pathology, Research and Practice
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