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Tumor vascular normalization

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https://www.readbyqxmd.com/read/29456207/medical-renal-disease-in-tumor-nephrectomies-the-silent-killer
#1
Rohit Tewari, Rajat Bajaj, Reena Bharadwaj
In tumor nephrectomy specimens, the evaluation of the normal renal parenchyma is often overlooked. A patient with both end-stage renal diseases (ESRDs) with a renal cell carcinoma is more likely to die of the ESRD rather than cancer. At the time of nephrectomy, a pathologist has a large amount of tissue available to him to comment upon the presence of disease in the nonneoplastic kidney. Hence, this study was undertaken with the idea of characterizing disease in the nonneoplastic kidney at the time of tumor nephrectomy...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29454129/delayed-post-traumatic-subacute-lumbar-subarachnoid-hematoma-case-report-and-review-of-the-literature
#2
Thiébaud Picart, Timothée Jacquesson, Emmanuel Jouanneau, Moncef Berhouma
BACKGROUND: Traumatic spinal subarachnoid hematoma, associated or not to a concurrent subdural hematoma has rarely been described. The evolution of such hematomas is heterogeneous. This study aims at defining the most accurate management which is currently not standardized. CASE DESCRIPTION: A 20-year-old man, victim of a high kinetic road accident five days before, suffering from several non-neurologic non-surgical vertebral fractures, complained of a sudden dorso-lumbar pain irradiating to his lower limbs...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29448307/histopathological-changes-resulting-from-selective-internal-radiotherapy-sirt
#3
Christoph Justinger, Juliana Gruden, Konstantinos Kouladouros, Christos Stravodimos, Peter Reimer, Andrea Tannapfel, Martin Binnenhei, Martin Bentz, Klaus Tatsch, Thomas Rüdiger, Michael R Schön
BACKGROUND: Selective internal radiotherapy (SIRT) has emerged as an effective therapy for patients with liver malignancies. Here, we report our analysis of histopathological changes in tumors and healthy liver tissue after SIRT and liver resection. Our main intent was to determine if specific histopathological changes occur in tumor and normal liver tissues. METHODS: We identified 17 patients in whom SIRT was applied to achieve liver resectability. Samples were taken from the resected liver tissue...
February 15, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29444818/sox7-promotes-high-grade-glioma-by-increasing-vegfr2-mediated-vascular-abnormality
#4
Il-Kug Kim, Kangsan Kim, Eunhyeong Lee, Dong Sun Oh, Chan Soon Park, Seongyeol Park, Jee Myung Yang, Ju-Hee Kim, Hyung-Seok Kim, David T Shima, Jeong Hoon Kim, Seok Ho Hong, Young Hyun Cho, Young Hoon Kim, Jong Bae Park, Gou Young Koh, Young Seok Ju, Heung Kyu Lee, Seungjoo Lee, Injune Kim
High-grade glioma (HGG) is highly angiogenic, but antiangiogenic therapy has transient clinical benefit in only a fraction of patients. Vascular regulators of these heterogeneous responses remain undetermined. We found up-regulation of Sox7 and down-regulation of Sox17 in tumor endothelial cells (tECs) in mouse HGG. Sox7 deletion suppressed VEGFR2 expression, vascular abnormality, hypoxia-driven invasion, regulatory T cell infiltration, and tumor growth. Conversely, Sox17 deletion exacerbated these phenotypes by up-regulating Sox7 in tECs...
February 14, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29442096/oral-and-masticatory-rehabilitation-using-osseointegrated-dental-implants-after-resective-treatment-of-multicystic-ameloblastoma-in-the-lower-jaw-with-a-fibula-graft
#5
João Ricardo Almeida Grossi, Tatiana Miranda Deliberador, Tielly Saad, Rafaela Scariot, Joao Cesar Zielak, Allan Fernando Giovanini
Ameloblastoma is an aggressive odontogenic tumor which typically occurs between third and fourth decade of life that often needs resective approach. Immediate reconstruction may show better results. The treatment of multicystic ameloblastoma in the mandible being a rare case that occurred in the late second decade of life, which was surgically removed along with the affected teeth with safety margins, and the region was immediately reconstructed using a vascularized graft, removed from the fibula. Its integration, in combination with osseointegrated dental implants and fixed implant-supported prostheses, restored chewing function and esthetics...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29435175/rest-upregulates-gremlin-to-modulate-diffuse-intrinsic-pontine-glioma-vasculature
#6
Shavali Shaik, Bridget Kennis, Shinji Maegawa, Keri Schadler, Yang Yanwen, Keri Callegari, Rishi R Lulla, Stewart Goldman, Javad Nazarian, Veena Rajaram, Jason Fangusaro, Vidya Gopalakrishnan
Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive glial tumor that occurs in children. The extremely poor median and 5-year survival in children afflicted with DIPG highlights the need for novel biology-driven therapeutics. Here, we have implicated the chromatin remodeler and regulator of brain development called RE1 Silencing Transcription Factor (REST), in DIPG pathology. We show that REST protein is aberrantly elevated in at least 21% of DIPG tumors compared to normal controls. Its knockdown in DIPG cell lines diminished cell growth and decreased their tumorigenicity in mouse intracranial models...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29434887/pi3k-akt-afadin-signaling-pathway-contributes-to-pathological-vascularization-in-glioblastomas
#7
Xuan Zhai, Yingliang Li, Ping Liang, Lusheng Li, Yudong Zhou, Weidan Zhang, Difei Wang, Guanghui Wei
Glioblastomas are brain tumors with extensive vascularization that are associated with tumor malignancy. The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway is activated in endothelial cell tumors, although its exact function in glioblastoma neovascularization is poorly characterized. The present study identified that endothelial cells derived from human glioblastomas exhibit increased permeability and motility compared with normal brain vascular endothelial cells. Furthermore, the phosphorylation of AKT was significantly induced in glioblastoma-derived endothelial cells and glioblastoma vessels...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434873/mechanisms-by-which-cxcr4-cxcl12-cause-metastatic-behavior-in-pancreatic-cancer
#8
Jianbo Zhang, Chengxin Liu, Xinkai Mo, Huan Shi, Sheng Li
C-X-C motif chemokine receptor (CXCR) 4/CXCL12 is associated with tumor invasion and metastasis in pancreatic cancer. The present study aimed to investigate the possible mechanisms behind this process by studying the association between the expression of CXCR4 and numerous molecular markers. A total of 60 patients with pancreatic cancer who had been treated with radical surgery between July 2012 and February 2016 were included in the present study. The expression of CXCR4/CXCL12 in primary pancreatic cancer lesions, tissues adjacent to cancerous tissue, non-cancerous pancreatic tissues and in the surrounding lymph nodes was evaluated by immunohistochemistry...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433538/microrna-193a-stimulates-pancreatic-cancer-cell-repopulation-and-metastasis-through-modulating-tgf-%C3%AE-2-tgf-%C3%AE-riii-signalings
#9
Chi Fang, Chen-Yun Dai, Zhu Mei, Ming-Jie Jiang, Dian-Na Gu, Qian Huang, Ling Tian
BACKGROUND: Pancreatic cancer characterizes high recurrence and poor prognosis. In clinical practice, radiotherapy is widely used for pancreatic cancer treatment. However, the outcome remains undesirable due to tumor repopulation and following recurrence and metastasis after radiation. So, it is highly needed to explore the underlying molecular mechanisms and accordingly develop therapeutic strategies. Our previous studies revealed that dying cells from chemoradiation could stimulate repopulation of surviving pancreatic cancer cells...
February 13, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29430239/a-case-of-paraneoplastic-remitting-seronegative-symmetrical-synovitis-with-pitting-edema-syndrome-improved-by-chemotherapy
#10
Takahiko Sakamoto, Shuji Ota, Terunobu Haruyama, Masashi Ishihara, Maika Natsume, Yoko Fukasawa, Shigeru Tanzawa, Ryo Usui, Takeshi Honda, Yasuko Ichikawa, Kiyotaka Watanabe, Nobuhiko Seki
The patient was a 69-year-old male who had started experiencing acute-onset pain in both shoulder joints and edema of both hands and feet. His symptoms progressively worsened within 1 month. Laboratory data indicated elevated CRP and erythrocyte sedimentation rate despite the normal range of antinuclear antibodies and rheumatoid factor and normal organ function. Furthermore, imaging data of the hand indicated synovitis without bone erosions. Meanwhile, chest CT revealed a lung tumor, leading to a diagnosis of primary lung adenocarcinoma with EGFR mutation (cT2aN3M0, stage IIIB)...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29427908/kinetics-of-viral-load-and-cytokines-in-severe-fever-with-thrombocytopenia-syndrome
#11
Ji-Soo Kwon, Min-Chul Kim, Ji Yeun Kim, Na-Young Jeon, Byung-Han Ryu, Jeongmin Hong, Min-Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
BACKGROUND: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China, Japan, and Korea, which is characterized by high fever, thrombocytopenia, and high mortality. It is hypothesized that a cytokine storm plays an important role in the pathophysiology of SFTS. However, limited data have been published on the detailed kinetics of the viral load and cytokine profiles throughout the course of this disease. OBJECTIVES: We investigated the patterns of changes in cytokines and viral load in SFTS patients...
January 31, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29426963/prostate-specific-membrane-antigen-psma-expression-in-breast-cancer-and-its-metastases
#12
Mariz Kasoha, Clara Unger, Erich-Franz Solomayer, Rainer M Bohle, Claudia Zaharia, Fadi Khreich, Stefan Wagenpfeil, Ingolf Juhasz-Böss
The present study was undertaken to investigate the expression of prostate-specific membrane antigen (PSMA) in normal breast tissues, in cancerous breast tissues and in distant metastases from patients with breast cancer. Immunohistochemical analysis was performed to determine PSMA expression and angiogenic activity using anti-PSMA mAb and anti-CD31 mAb respectively. Immunofluorescence staining was applied to confirm the exact co-localization of PSMA and CD31. We observed different patterns of PSMA expression between normal and cancerous tissues...
February 10, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29423081/pm2-5-inhalation-induces-intracranial-atherosclerosis-which-may-be-ameliorated-by-omega-3-fatty-acids
#13
Longfei Guan, Xiaokun Geng, Jiamei Shen, James Yip, Fengwu Li, Huishan Du, Zhili Ji, Yuchuan Ding
Background: Intracranial atherosclerosis (ICA) a major health problem. This study investigated whether inhalation of fine airborne particulate matters (PM2.5) causes ICA and whether omega-3 fatty acids (O3FA) attenuated the development of ICA. Results: Twelve but not 6 week exposure significantly increased triglycerides (TG) in normal chow diet (NCD), while PM2.5 enhanced all lipid profiles (TG, low density lipoprotein (LDL) and cholesterol (CHO)) after both 6 and 12-week exposure with high-cholesterol diet (HCD)...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29419946/photoacoustic-microscopy-for-evaluating-combretastatin-a4-phosphate-induced-vascular-disruption-in-orthotopic-glioma
#14
Renzhe Bi, Ghayathri Balasundaram, Seungwan Jeon, Hui Chien Tay, Yang Pu, Xiuting Li, Mohesh Moothanchery, Chulhong Kim, Malini Olivo
The use of an optical resolution photoacoustic microscopy system (OR-PAM) to evaluate the vascular disruptive effect of Combretastatin A4 Phosphate (CA4P) on a murine orthotopic glioma with intact skull is described here. Second generation optical-resolution PAM scanner with a 532 nm pulsed diode-pumped solid-state (DPSS) laser that specifically matches the absorption maximum of haemoglobin in tissues was used to image orthotopic glioma inoculated in mouse brain. 2D maps of brain vasculature with a lateral resolution of 5 μm and a depth of 700 μm at a field of view 5 × 4 mm were acquired on normal brain and glioma brain...
February 8, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29417360/42-573-cases-of-hepatectomy-in-china-a-multicenter-retrospective-investigation
#15
Binhao Zhang, Bixiang Zhang, Zhiwei Zhang, Zhiyong Huang, Yifa Chen, Minshan Chen, Ping Bie, Baogang Peng, Liqun Wu, Zhiming Wang, Bo Li, Jia Fan, Lunxiu Qin, Ping Chen, Jingfeng Liu, Zhe Tang, Jun Niu, Xinmin Yin, Deyu Li, Songqing He, Bin Jiang, Yilei Mao, Weiping Zhou, Xiaoping Chen
Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma (HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed...
February 2, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29416164/retrospective-analysis-of-giant-cell-tumor-lower-end-radius-treated-with-en-bloc-excision-and-translocation-of-ulna
#16
Amit Vyas, Purnima Patni, Narender Saini, Rahul Sharma, Vinit Arora, S P Gupta
Background: Distal end of radius is third most common site for GCT of long bones and 1% of these metastasize mostly to lungs. Reconstruction methods commonly used are fibula (vascularized and nonvascularized), centralization of ulna, translocation of ulna, and endoprosthetic replacement. We report the outcome of series of twenty cases where we did en bloc excision of tumor with translocation of ulna. Materials and Methods: Twenty cases of giant cell tumor (GCT) of lower end of radius were included in this retrospective study...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29404256/modified-one-piece-extended-transbasal-approach-for-endoscopic-assisted-microsurgical-resection-of-tuberculum-sellae-meningioma-operative-video-and-technical-nuances
#17
James K Liu, Kentaro Watanabe
The optimal approach for surgical resection of tuberculum sellae meningiomas remains controversial. Approach selection is largely based on a variety of factors, such as tumor size, extent and location relative to the optic canal and internal carotid artery, the presence of vascular encasement, and surgeon's preference. In this operative video manuscript, the authors demonstrate the importance of an open transcranial approach when the tumor extends lateral to the optic nerve over the internal carotid artery into the opticocarotid triangle, which is a difficult region to safely access with a purely endoscopic endonasal approach...
February 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29404255/one-piece-orbitozygomatic-craniotomy-for-resection-of-rathke-s-cleft-cyst-operative-video
#18
Rimal H Dossani, Devi P Patra, Christopher Storey, Piyush Kalakoti, Hai Sun
Objective  The video stars orbitozygomatic resection of Rathke's cleft cyst with suprasellar extension in a 37-year-old male patient presenting with severe headaches and bitemporal hemianopia. Clinical and radiological characteristics along with surgical technique (positioning, bony opening, surgical dissection and debulking, closure), histopathology, and postoperative course are described. Methods  Preoperative MRI demonstrated a noncontrast-enhancing cystic lesion in the sella with suprasellar extension causing compression of both optic nerves...
February 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29403275/development-of-biocompatible-and-vegf-targeted-paclitaxel-nanodrugs-on-albumin-and-graphene-oxide-dual-carrier-for-photothermal-triggered-drug-delivery-in-vitro-and-in-vivo
#19
Wentao Deng, Juhui Qiu, Shaoting Wang, Zhi Yuan, Yuefeng Jia, Hailin Tan, Jiru Lu, Ruqiang Zheng
In this study, we performed the characterization and synthesis of biocompatible and targeted albumin and graphene oxide (GO) dual-carrier paclitaxel (PTX) nanoparticles for photothermal-triggered tumor therapy. PTX absorbed on GO nanosheets as cores were coated with human serum albumin (HSA), following surface conjugation with monoclonal antibodies (mAb) against vascular endothelial growth factor (VEGF; denoted as mAbVEGF) via polyethylene glycol linker to form targeted nanoparticles (PTX-GHP-VEGF). The spherical nanoparticles were 191±5 nm in size with good stability and biocompatibility...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29399278/current-state-and-clinical-outcome-in-turkish-patients-with-hepatocellular-carcinoma
#20
Omer Ekinci, Bulent Baran, Asli Cifcibasi Ormeci, Ozlem Mutluay Soyer, Suut Gokturk, Sami Evirgen, Arzu Poyanli, Mine Gulluoglu, Filiz Akyuz, Cetin Karaca, Kadir Demir, Fatih Besisik, Sabahattin Kaymakoglu
AIM: To investigate clinical, etiological, and prognostic features in patients with hepatocellular carcinoma. METHODS: Patients with hepatocellular carcinoma who were followed-up from 2001 to 2011 were included in the study. The diagnosis was established by histopathological and/or radiological criteria. We retrospectively reviewed clinical and laboratory data, etiology of primary liver disease, imaging characteristics and treatments. Child-Pugh and Barcelona Clinic Liver Cancer stage was determined at initial diagnosis...
January 27, 2018: World Journal of Hepatology
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