keyword
https://read.qxmd.com/read/38480803/exploring-the-anatomical-configurations-of-the-cerebral-arteries-in-a-cohort-of-south-african-patients
#21
JOURNAL ARTICLE
Gugulethu Sibiya, Bukola R Omotoso, Rohen Harrichandparsad, Lelika Lazarus
The cerebral arteries, specifically the anterior cerebral artery (ACA) and posterior cerebral artery (PCA), work together with the smaller calibre arteries to provide effective communication between the anterior and posterior circuits of the brain via the circle of Willis (CoW). Morphologic variations of the cerebral arteries and the CoW may alter blood flow to the brain, resulting in intracranial vascular disorders associated with stroke, and aneurysms. This study aimed to document the morphology of the cerebral arteries and the CoW in the South African population...
March 13, 2024: Scientific Reports
https://read.qxmd.com/read/38480591/dysplastic-aberrant-left-subclavian-artery-originating-from-a-thoracic-intersegmental-artery-associated-with-a-right-aortic-arch
#22
JOURNAL ARTICLE
Kohei Ishikawa, Yasufumi Ohtake, Mamoru Fukuda, Hideki Endo, Hirohiko Nakamura
PURPOSE: A right aortic arch (RAA) is a rare vascular anomaly that often coexists with an aberrant left subclavian artery (ALSA). Due to the rarity of RAA, the development of an ALSA is not well understood. METHOD: We describe a case in which a 58-year-old man who was scheduled to undergo posterior decompression and fusion surgery for thoracic ossification of the posterior longitudinal ligament from Th1 to Th3 was found to have a RAA and an ALSA. RESULTS: Preoperative computed tomography angiography demonstrated a RAA and an ALSA...
March 13, 2024: Surgical and Radiologic Anatomy: SRA
https://read.qxmd.com/read/38479129/nutrient-vessel-dysfunction-can-contribute-to-mucoid-degeneration-of-the-posterior-cruciate-ligament-coexisting-with-lipoma-arborescens-a-case-study
#23
Akira Inoue
INTRODUCTION: With the rapid improvement of magnetic resonance imaging (MRI), mucoid degeneration (MD) of the anterior cruciate ligament (MD-ACL) has become an established disease entity and mechanical factors, such as increased posterior tibial tilt and intercondylar notch impingement, have been proposed. However, symptomatic MD of the posterior cruciate ligament (MD-PCL) remains an orphan disease without any established etiology. PRESENTATION OF CASE: A man in his 60s exhibited restricted range of motion with knee pain...
March 5, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38478907/central-retinal-artery-occlusion-after-cardioversion-of-atrial-fibrillation
#24
JOURNAL ARTICLE
Lilia Lagha, Dimitrios Kalogeropoulos, Srinivas Goverdhan, Andrew J Lotery
Central retinal artery occlusion (CRAO) is a vascular ophthalmic emergency. Often caused by a sudden interruption of blood flow to the eye, with profound and painless vision loss, resulting in irreversible cell damage. An impacted embolus at the narrowest part of the central retinal artery is the most common cause. Cardioversion is a medical procedure used to restore a normal heart rhythm in individuals with atrial fibrillation (AF). In some cases, cardioversion can lead to thromboembolic complications. If an embolus reaches the central retinal artery, it can block the blood flow to the retina, resulting in CRAO and subsequent vision loss...
March 12, 2024: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38478616/the-%C3%AE-catenin-c-terminus-links-wnt-and-sphingosine-1-phosphate-signaling-pathways-to-promote-vascular-remodeling-and-atherosclerosis
#25
JOURNAL ARTICLE
Gustavo H Oliveira-Paula, Sophia Liu, Alishba Maira, Gaia Ressa, Graziele C Ferreira, Amado Quintar, Smitha Jayakumar, Vanessa Almonte, Dippal Parikh, Tomas Valenta, Konrad Basler, Timothy Hla, Dario F Riascos-Bernal, Nicholas E S Sibinga
Canonical Wnt and sphingosine-1-phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, and cardiovascular system function; despite these functional overlaps, little is known about Wnt/β-catenin-S1P cross-talk. In the vascular system, both Wnt/β-catenin and S1P signals affect vessel maturation, stability, and barrier function, but information regarding their potential coordination is scant. We report an instance of functional interaction between the two pathways, including evidence that S1P receptor 1 (S1PR1) is a transcriptional target of β-catenin...
March 15, 2024: Science Advances
https://read.qxmd.com/read/38477704/aortic-calcification-is-associated-with-the-difference-between-invasive-central-and-cuff-measured-brachial-blood-pressure-in-chronic-kidney-disease
#26
JOURNAL ARTICLE
Jakob Nyvad, Kent Lodberg Christensen, Gratien Andersen, Mark Reinhard, Michael Maeng, Sebastian Nielsen, Martin Bjergskov Thomsen, Jesper Møller Jensen, Bjarne Linde Nørgaard, Niels Henrik Buus
OBJECTIVE: Chronic kidney disease (CKD) is associated with accelerated vascular calcification and increased central systolic blood pressure when measured invasively (invCSBP) relative to cuff-based brachial systolic blood pressure (cuffSBP). The contribution of aortic wall calcification to this phenomenon has not been clarified. We therefore examined the effects of aortic calcification on cuffSBP and invCSBP in a cohort of patients representing all stages of CKD. METHODS: During elective coronary angiography, invCSBP was measured in the ascending aorta with a fluid-filled catheter with simultaneous recording of cuffSBP using an oscillometric device...
March 13, 2024: American Journal of Hypertension
https://read.qxmd.com/read/38477161/b-flow-spatiotemporal-image-correlation-m-mode-ultrasound-provides-novel-method-to-quantify-spiral-artery-remodeling-during-normal-human-pregnancy
#27
JOURNAL ARTICLE
O M Turan, Y Liang, B Kelley, S Turan, G J Pepe, E D Albrecht
OBJECTIVES: During human pregnancy placental extravillous trophoblasts replace the vascular smooth muscle and elastic tissue within the walls of the uterine spiral arteries, thereby remodeling these arteries into distensible low resistance vessels to promote placental perfusion. The present study, determined whether B-flow/ spatio-temporal image correlation (STIC) M-mode ultrasonography provides an in vivo imaging method to digitally quantify spiral artery luminal distensibility, as a physiological index of spiral artery remodeling, during advancing stages of normal human pregnancy...
March 13, 2024: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/38475941/endothelial-specific-telomerase-inactivation-causes-telomere-independent-cell-senescence-and-multi-organ-dysfunction-characteristic-of-aging
#28
JOURNAL ARTICLE
Zhanguo Gao, Rafael Bravo Santos, Joseph Rupert, Rachel Van Drunen, Yongmei Yu, Kristin Eckel-Mahan, Mikhail G Kolonin
It has remained unclear how aging of endothelial cells (EC) contributes to pathophysiology of individual organs. Cell senescence results in part from inactivation of telomerase (TERT). Here, we analyzed mice with Tert knockout specifically in EC. Tert loss in EC induced transcriptional changes indicative of senescence and tissue hypoxia in EC and in other cells. We demonstrate that EC-Tert-KO mice have leaky blood vessels. The blood-brain barrier of EC-Tert-KO mice is compromised, and their cognitive function is impaired...
March 12, 2024: Aging Cell
https://read.qxmd.com/read/38475835/tracheal-agenesis-versus-tracheal-atresia-anatomical-conditions-pathomechanisms-and-causes-with-a-possible-link-to-a-novel-mapk11-variant-in-one-case
#29
JOURNAL ARTICLE
Mateja Pfeifer, Helga Rehder, Maria Gerykova Bujalkova, Christine Bartsch, Barbara Fritz, Cordula Knopp, Björn Beckers, Frank Dohle, Matthias Meyer-Wittkopf, Roland Axt-Fliedner, Alexander V Beribisky, Manuel Hofer, Franco Laccone, Katharina Schoner
BACKGROUND: In this study we aimed to describe the morphological and pathogenetic differences between tracheal agenesis and tracheal atresia, which are not clearly distinguished from each other in the literature, and to contribute thereby to the understanding and management of these conditions. Both tracheal agenesis and tracheal atresia represent rare disorders of still unknown aetiology that cannot be detected by prenatal ultrasound. If the affected foetuses survive until birth these conditions result in respiratory failure and in futile attempts to rescue the infant's life...
March 12, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38473847/functional-structural-and-proteomic-effects-of-ageing-in-resistance-arteries
#30
REVIEW
Lars Jørn Jensen
The normal ageing process affects resistance arteries, leading to various functional and structural changes. Systolic hypertension is a common occurrence in human ageing, and it is associated with large artery stiffening, heightened pulsatility, small artery remodeling, and damage to critical microvascular structures. Starting from young adulthood, a progressive elevation in the mean arterial pressure is evidenced by clinical and epidemiological data as well as findings from animal models. The myogenic response, a protective mechanism for the microcirculation, may face disruptions during ageing...
February 23, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473252/blood-vessel-targeted-therapy-in-colorectal-cancer-current-strategies-and-future-perspectives
#31
REVIEW
Anne Jacobsen, Jürgen Siebler, Robert Grützmann, Michael Stürzl, Elisabeth Naschberger
The vasculature is a key player and regulatory component in the multicellular microenvironment of solid tumors and, consequently, a therapeutic target. In colorectal carcinoma (CRC), antiangiogenic treatment was approved almost 20 years ago, but there are still no valid predictors of response. In addition, treatment resistance has become a problem. Vascular heterogeneity and plasticity due to species-, organ-, and milieu-dependent phenotypic and functional differences of blood vascular cells reduced the hope of being able to apply a standard approach of antiangiogenic therapy to all patients...
February 22, 2024: Cancers
https://read.qxmd.com/read/38473074/maternal-supplementation-with-ornithine-promotes-placental-angiogenesis-and-improves-intestinal-development-of-suckling-piglets
#32
JOURNAL ARTICLE
Yun Yang, Guanyu Hou, Fengjie Ji, Hanlin Zhou, Renlong Lv, Chengjun Hu
The blood vessels of the placenta are crucial for fetal growth. Here, lower vessel density and ornithine (Orn) content were observed in placentae for low-birth-weight fetuses versus normal-birth-weight fetuses at day 75 of gestation. Furthermore, the Orn content in placentae decreased from day 75 to 110 of gestation. To investigate the role of Orn in placental angiogenesis, 48 gilts (Bama pig) were allocated into four groups. The gilts in the control group were fed a basal diet (CON group), while those in the experimental groups were fed a basal diet supplemented with 0...
February 22, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38473022/quantitative-ct-texture-analysis-of-covid-19-hospitalized-patients-during-3-24-month-follow-up-and-correlation-with-functional-parameters
#33
JOURNAL ARTICLE
Salvatore Claudio Fanni, Federica Volpi, Leonardo Colligiani, Davide Chimera, Michele Tonerini, Francesco Pistelli, Roberta Pancani, Chiara Airoldi, Brian J Bartholmai, Dania Cioni, Laura Carrozzi, Emanuele Neri, Annalisa De Liperi, Chiara Romei
BACKGROUND: To quantitatively evaluate CT lung abnormalities in COVID-19 survivors from the acute phase to 24-month follow-up. Quantitative CT features as predictors of abnormalities' persistence were investigated. METHODS: Patients who survived COVID-19 were retrospectively enrolled and underwent a chest CT at baseline (T0) and 3 months (T3) after discharge, with pulmonary function tests (PFTs). Patients with residual CT abnormalities repeated the CT at 12 (T12) and 24 (T24) months after discharge...
March 5, 2024: Diagnostics
https://read.qxmd.com/read/38472215/hypoxia-and-low-glucose-environments-co-induced-hgdilnc1-promote-glycolysis-and-angiogenesis
#34
JOURNAL ARTICLE
Qing-Wei Zhang, Xiao-Lu Lin, Zi-Hao Dai, Ran Zhao, Yi-Chao Hou, Qian Liang, Yan Zhang, Zhi-Zheng Ge
Small bowel vascular malformation disease (SBVM) commonly causes obscure gastrointestinal bleeding (OGIB). However, the pathogenetic mechanism and the role of lncRNAs in SBVM remain largely unknown. Here, we found that hypoxia and low-glucose environments co-augment angiogenesis and existed in SBVM. Mechanistically, hypoxia and low-glucose environments supported angiogenesis via activation of hypoxia and glucose deprivation-induced lncRNA (HGDILnc1) transcription by increasing binding of the NeuroD1 transcription factor to the HGDILnc1 promoter...
March 12, 2024: Cell Death Discovery
https://read.qxmd.com/read/38469759/an-atherosclerosis-indicator-hyaluronic-acid-can-plasma-hyaluronic-acid-be-useful-in-diagnosing-alzheimer-s-disease
#35
JOURNAL ARTICLE
Serdar Ceylan, Merve Guner, Arzu Okyar-Bas, Zeynep Kahyaoglu, Neriman S Koc, Gamze N Koksal, Yasin Kiran, Aykut Sagir, Cafer Balci, Meltem G Halil, Mustafa Cankurtaran, Tolga Yildirim, Incilay Lay, Burcu B Dogu
BACKGROUND: The aim is to compare the plasma levels of hyaluronic acid (HA) which is closely related to inflam-mation and vascular changes and arterial stiffness (AS) related values in patients with Alzheimer's disease (AD), amnestic type mild cognitive impairment (aMCI), and normal cognitive functions (NCF). METHODS: Ninety participants were categorized into three groups, patients with AD, MCI, and NCF. Arterial stiffness measurement in the nephrology outpatient clinic, and storage and analysis of plasma samples in the biochemistry laboratory...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38469605/identifying-factors-associated-with-non-mesenterovascular-pathology-in-patients-undergoing-surgical-treatment-for-acute-mesenteric-ischemia
#36
JOURNAL ARTICLE
Mustafa Karaagac, Fatih Dal, Tutkun Talih, Muhammet Akyuz, Erdogan Mutevelli Sozuer, Hizir Yakup Akyildiz
AIM: To identify factors that can help us to avoid a preoperative incorrect diagnosis of vascular occlusion by evaluating patients who underwent laparotomy with a probable preoperative diagnosis of acute mesenteric ischemia (AMI), but later at laparotomy, were diagnosed to have a different pathology than AMI. MATERIAL AND METHODS: A total of 213 patients who were operated with the diagnosis of AMI were enrolled in this study. Based on their operational, clinical, and pathological findings, they were divided into two groups...
2024: Annali Italiani di Chirurgia
https://read.qxmd.com/read/38468264/cardiopulmonary-exercise-test-to-detect-cardiac-dysfunction-from-pulmonary-vascular-disease
#37
REVIEW
Mona Alotaibi, Jenny Z Yang, Demosthenes G Papamatheakis, W Cameron McGuire, Timothy M Fernandes, Timothy A Morris
BACKGROUND: Cardiac dysfunction from pulmonary vascular disease causes characteristic findings on cardiopulmonary exercise testing (CPET). We tested the accuracy of CPET for detecting inadequate stroke volume (SV) augmentation during exercise, a pivotal manifestation of cardiac limitation in patients with pulmonary vascular disease. METHODS: We reviewed patients with suspected pulmonary vascular disease in whom CPET and right heart catheterization (RHC) measurements were taken at rest and at anaerobic threshold (AT)...
March 11, 2024: Respiratory Research
https://read.qxmd.com/read/38467721/novel-theory-and-potential-applications-of-central-diastolic-pressure-decay-time-constant
#38
JOURNAL ARTICLE
Vasiliki Bikia, Patrick Segers, Georgios Rovas, Sokratis Anagnostopoulos, Nikolaos Stergiopulos
Central aortic diastolic pressure decay time constant ( <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mi>τ</mml:mi></mml:math> ) is according to the two-element Windkessel model equal to the product of total peripheral resistance ( <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mi>R</mml:mi></mml:math> ) times total arterial compliance ( <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"><mml:mi>C</mml:mi></mml:math> )...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38467666/pulmonary-vascular-reactivity-in-growth-restricted-fetuses-using-computational-modelling-and-machine-learning-analysis-of-fetal-doppler-waveforms
#39
JOURNAL ARTICLE
Kilian Vellvé, Patricia Garcia-Canadilla, Mariana Nogueira, Lina Youssef, Angela Arranz, Ayako Nakaki, David Boada, Isabel Blanco, Rosa Faner, Francesc Figueras, Àlvar Agustí, Eduard Gratacós, Francesca Crovetto, Bart Bijnens, Fàtima Crispi
The aim of this study was to investigate the pulmonary vasculature in baseline conditions and after maternal hyperoxygenation in growth restricted fetuses (FGR). A prospective cohort study of singleton pregnancies including 97 FGR and 111 normally grown fetuses was carried out. Ultrasound Doppler of the pulmonary vessels was obtained at 24-37 weeks of gestation and data were acquired before and after oxygen administration. After, Machine Learning (ML) and a computational model were used on the Doppler waveforms to classify individuals and estimate pulmonary vascular resistance (PVR)...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38466346/transcatheter-aortic-valve-implantation-in-patients-with-significant-septal-hypertrophy
#40
JOURNAL ARTICLE
Martin Beyer, Till Joscha Demal, Oliver D Bhadra, Matthias Linder, Sebastian Ludwig, David Grundmann, Lisa Voigtlaender-Buschmann, Lara Waldschmidt, Johannes Schirmer, Niklas Schofer, Simon Pecha, Stefan Blankenberg, Hermann Reichenspurner, Lenard Conradi, Moritz Seiffert, Andreas Schaefer
BACKGROUND: Previous reports suggest septal hypertrophy with an interventricular septum depth (IVSD) ≥ 14 mm may adversely affect outcomes after transcatheter aortic valve implantation (TAVI) due to suboptimal valve placement, valve migration, or residual increased LVOT pressure gradients. AIMS: This analysis investigates the impact of interventricular septal hypertrophy on acute outcomes after TAVI. METHODS: Between 2009 and 2021, 1033 consecutive patients (55...
March 11, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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