Gustavo H Oliveira-Paula, Sophia Liu, Alishba Maira, Gaia Ressa, Graziele C Ferreira, Amado Quintar, Smitha Jayakumar, Vanessa Almonte, Dippal Parikh, Tomas Valenta, Konrad Basler, Timothy Hla, Dario F Riascos-Bernal, Nicholas E S Sibinga
Canonical Wnt and sphingosine-1-phosphate (S1P) signaling pathways are highly conserved systems that contribute to normal vertebrate development, with key consequences for immune, nervous, and cardiovascular system function; despite these functional overlaps, little is known about Wnt/β-catenin-S1P cross-talk. In the vascular system, both Wnt/β-catenin and S1P signals affect vessel maturation, stability, and barrier function, but information regarding their potential coordination is scant. We report an instance of functional interaction between the two pathways, including evidence that S1P receptor 1 (S1PR1) is a transcriptional target of β-catenin...
March 15, 2024: Science Advances