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https://www.readbyqxmd.com/read/29166648/different-response-to-hypoxia-of-adipose-derived-multipotent-cells-from-obese-subjects-with-and-without-metabolic-syndrome
#1
Wilfredo Oliva-Olivera, Isabel Moreno-Indias, Leticia Coín-Aragüez, Said Lhamyani, Juan Alcaide Torres, Sonia Fernández-Veledo, Joan Vendrell, Antonio Camargo, Rajaa El Bekay, Francisco José Tinahones
BACKGROUND/OBJECTIVES: Multiple studies suggest that hypoxia, together with inflammation, could be one of the phenomena involved in the onset and progression of obesity-related insulin resistance. In addition, dysfunction of adipose tissue in obese subjects with metabolic syndrome is associated with decreased angiogenesis. However, some subjects with a high body mass index do not develop metabolic abnormalities associated with obesity. The aim of the current study was to examine the neovascular properties of visceral adipose tissue-derived multipotent mesenchymal cells subjected to hypoxia (hypox-visASCs) from normal-weight subjects (Nw) and obese patients with metabolic syndrome (MS) and without metabolic syndrome (NonMS)...
2017: PloS One
https://www.readbyqxmd.com/read/29164133/role-of-dietary-antioxidants-in-the-preservation-of-vascular-function-and-the-modulation-of-health-and-disease
#2
REVIEW
Saradhadevi Varadharaj, Owen J Kelly, Rami N Khayat, Purnima S Kumar, Naseer Ahmed, Jay L Zweier
In vascular diseases, including hypertension and atherosclerosis, vascular endothelial dysfunction (VED) occurs secondary to altered function of endothelial nitric oxide synthase (eNOS). A novel redox regulated pathway was identified through which eNOS is uncoupled due to S-glutathionylation of critical cysteine residues, resulting in superoxide free radical formation instead of the vasodilator molecule, nitric oxide. In addition, the redox sensitive cofactor tetrahydrobiopterin, BH4, is also essential for eNOS coupling...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29163690/delisheng-induces-antiproliferation-and-apoptosis-effects-in-hep3b-cells-via-modulation-of-angiogenic-proteins
#3
Hai-Feng Sun, Li Jing, Tao Wu, Ming Li, Ya-Huan Guo, Hui Guo, Zheng Zhao, Min-Cong Wang, Shu-Hong Wang, Ke-Jun Nan
Delisheng is a widely used antineoplastic agent in China. Although previous studies revealed that Delisheng exhibits numerous pharmacological effects including the inhibition of cancer cell differentiation and enhancement of immune function with the lowest toxicity, the precise anticancer mechanisms of Delisheng in human hepatocellular carcinoma (HCC) cells remains largely unknown. The present study investigated the potential mechanisms underlying the anticancer properties of Delisheng on Hep3B cells. Delisheng demonstrated a strong anti-proliferation effect on Hep3B cells compared with normal liver HL-7702 cells, as detected by MTT assays...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29163203/cyclic-stretch-alters-vascular-reactivity-of-mouse-aortic-segments
#4
Arthur Leloup, Sofie De Moudt, Cor Van Hove, Paul Fransen
Large, elastic arteries buffer the pressure wave originating in the left ventricle and are constantly exposed to higher amplitudes of cyclic stretch (10%) than muscular arteries (2%). As a crucial factor for endothelial and smooth muscle cell function, cyclic stretch has, however, never been studied in ex vivo aortic segments of mice. To investigate the effects of cyclic stretch on vaso-reactivity of mouse aortic segments, we used the Rodent Oscillatory Tension Set-up to study Arterial Compliance (ROTSAC). The aortic segments were clamped at frequencies of 6-600 bpm between two variable preloads, thereby mimicking dilation as upon left ventricular systole and recoiling as during diastole...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163168/atheroregressive-potential-of-the-treatment-with-a-chimeric-monoclonal-antibody-against-sulfated-glycosaminoglycans-on-pre-existing-lesions-in-apolipoprotein-e-deficient-mice
#5
Victor Brito, Katia Mellal, Karina F Zoccal, Yosdel Soto, Liliane Ménard, Roger Sarduy, Lucia H Faccioli, Huy Ong, Ana M Vázquez, Sylvie Marleau
The retention of lipoprotein particles in the intima, in particular to glycosaminoglycan side chains of proteoglycans, is a critical step in atherosclerosis initiation. Administration of chP3R99, a chimeric mouse/human monoclonal antibody inducing an anti-idiotypic network response against glycosaminoglycans was previously shown to prevent atherosclerotic lesion progression, yet its effect in the late-stage progression of lesions remains unknown. This study investigated the effect of chP3R99 at a late stage of disease development in apolipoprotein E-deficient mice and the vascular mechanisms involved...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29162889/identification-of-micrornas-as-potential-cellular-monocytic-biomarkers-in-the-early-phase-of-myocardial-infarction-a-pilot-study
#6
Mariana S Parahuleva, Gerhild Euler, Amar Mardini, Behnoush Parviz, Bernhard Schieffer, Rainer Schulz, Muhammad Aslam
MicroRNA has been increasingly suggested to be involved in vascular inflammation. The aim of this study was to assess the expression profile of miRs as possible novel cellular biomarkers in circulating monocytes in patients with ST-segment elevation myocardial infarction (STEMI). Microarray techniques and TaqMan polymerase chain reaction were used to analyse the global expression of 352 miRNAs in peripheral blood monocytes from healthy donors (n = 20) and patients (n = 24) with acute STEMI. The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29162296/early-outcomes-of-vein-grafting-for-reconstruction-of-brachial-arterial-injuries-in-children
#7
Kristin Alves, Hillard Spencer, Carol E Barnewolt, Peter M Waters, Donald S Bae
PURPOSE: We postulated that, with microsurgical technique, vascular reconstruction with interpositional vein grafts in the pediatric population is safe and results in sustained vascular patency and excellent midterm outcomes. METHODS: Twenty children with brachial artery injuries were treated with interpositional vein grafting at a tertiary pediatric hospital from 1995 to 2013. Medical records were evaluated for demographic, clinical, and radiographic data. Ten patients were available for longer-term follow-up...
November 18, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29161683/out-of-the-blue-finger-ischaemia-and-occult-colorectal-cancer
#8
Ami Schattner
A woman aged 66 years with a history of unprovoked deep venous thrombosis (DVT) presented with persistent digital ischaemic changes of 2 of her right hand fingers. Physical examination was otherwise normal and extensive laboratory and imaging studies were unremarkable. A history of unprovoked DVT and the current episode of digital ischaemia prompted concern for underlying occult malignancy. Repeated history-taking revealed a strongly positive family history suggesting an occult colorectal cancer. Colonoscopy with biopsy revealed adenocarcinoma...
March 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29160954/islet-allo-autotransplantation-allogeneic-pancreas-transplantation-followed-by-transplant-pancreatectomy-and-islet-transplantation
#9
M F Nijhoff, J Dubbeld, A R van Erkel, P J M van der Boog, T J Rabelink, M A Engelse, E J P de Koning
Simultaneous pancreas/kidney (SPK) transplantation is an important treatment option for patients with type 1 diabetes (T1D) and end stage renal disease (ESRD). Due to complications, in up to 10% of cases allograft pancreatectomy is necessary shortly after transplantation. Usually the donor pancreas is discarded. Here we report on a novel procedure to rescue endocrine tissue after allograft pancreatectomy. A 39-year-old woman with T1D and ESRD who had received an SPK transplantation required emergency allograft pancreatectomy due to bleeding at the vascular anastomosis...
November 21, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29160086/anatomic-and-radiologic-study-of-renal-avascular-plane-brodel-s-line-and-its-potential-relevance-on-percutaneous-and-surgical-approaches-to-the-kidney
#10
Veronica Macchi, Edgardo Picardi, Antonino Inferrera, Andrea Porzionato, Alessandro Crestani, Giacomo Novara, Raffaele De Caro, Vincenzo Ficarra
OBJECTIVE: The aim of the present anatomic and radiologic study was to evaluate the location, extension and characteristics of the Brödel's plane and eventually define its different patterns. MATERIAL AND METHODS: We evaluated 15 human normal kidneys sampled from un-embalmed cadavers without clinical history or anatomical evidence of renal diseases. Kidneys with the surrounding perirenal fat tissue were removed en bloc with the abdominal segment of the aorta. The renal artery was injected with acrylic and radiopaque resins...
November 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29159794/high-fat-high-sugar-diet-induced-subendothelial-matrix-stiffening-is-mitigated-by-exercise
#11
Julie C Kohn, Julian Azar, Francesca Seta, Cynthia A Reinhart-King
Consumption of a high-fat, high-sugar diet and sedentary lifestyle are correlated with bulk arterial stiffening. While measurements of bulk arterial stiffening are used to assess cardiovascular health clinically, they cannot account for changes to the tissue occurring on the cellular scale. The compliance of the subendothelial matrix in the intima mediates vascular permeability, an initiating step in atherosclerosis. High-fat, high-sugar diet consumption and a sedentary lifestyle both cause micro-scale subendothelial matrix stiffening, but the impact of these factors in concert remains unknown...
November 20, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29158852/curative-metatarsal-bone-surgery-combined-with-intralesional-administration-of-recombinant-human-epidermal-growth-factor-in-diabetic-neuropathic-ulceration-of-the-forefoot-a-prospective-open-uncontrolled-nonrandomized-observational-study
#12
Aristides L Garcia Herrera, Ridel de Jesús Febles Sanabria, Liliana de Los Ángeles Acosta Cabadilla, Miriam Moliner Cartaya
Background: Curative surgery is performed for a foot with ulcers and loss of protective sensation to heal the wound and prevent amputation. Evidence supports that patients with diabetes have decreased concentrations of growth factors in their tissues, notably epidermal growth factor (EGF). Injecting EGF deep into the bottom of the wound and its contours encourages a more effective response in terms of granulation tissue growth and wound closure. Objective: To assess the effectiveness and safety of curative metatarsal bone surgery combined with intralesional administration of human recombitant EGF in neuropathic diabetic forefoot ulceration...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158804/heparanase-contributes-to-trans-endothelial-migration-of-hepatocellular-carcinoma-cells
#13
Xiaopeng Chen, Wen Jiang, Chaofu Yue, Wenjun Zhang, Chaogang Tong, Dafei Dai, Bin Cheng, Chen Huang, Linming Lu
The overall outcome of patients with hepatocellular carcinoma (HCC) is still very poor due to its high metastasis and recurrence rate. During metastasis, trans-endothelial migration (TEM) of HCC cells is a key step. Heparanase (HPSE) is an endo-beta-glucuronidase and exerts prometastatic properties for normal and tumor-derived cells. However, it is remains unclear that HPSE contributes to TEM of HCC cells. In this study, human umbilical vein endothelial cells-C (HUVEC-C) was used to simulate vascular endothelial cells (VECs), and the HCCLM3 cells with high HPSE expression were chosen and used for in vitro TEM assay and in vivo experiment...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29158187/white-matter-structural-integrity-and-trans-cranial-doppler-blood-flow-pulsatility-in-normal-aging
#14
Roman Fleysher, Michael L Lipton, Olga Noskin, Tatjana Rundek, Richard Lipton, Carol A Derby
Cerebrovascular diseases underlie many forms of age-related cognitive impairment and the mechanism linking the two is hypothesized to involve adverse changes in white matter (WM) integrity. Despite being systemic, small vessel disease does not uniformly affect WM. We performed voxel-wise analysis of MRI images to examine the association between fractional anisotropy (FA) - a diffusion tensor measure of WM structural integrity - and pulsatility index (PI) - a transcranial Doppler ultrasound measure of abnormal arterial flow - in adults over the age of 70 years who were free of stroke and dementia...
November 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29157938/-vascular-adrenal-cyst-causing-difficult-to-control-high-blood-pressure
#15
D García Escudero, M Torres Roca, M E Hernández Contreras, C Sánchez Rodríguez, J Oñate Celdrán
Hypertension is a prevalent disease in developed countries. Adrenal masses, and especially adrenal cysts, are a rare and usually asymptomatic finding, which can go unnoticed or be detected as incidental findings in imaging tests. These circumstances make the multidisciplinary approach mandatory. The case is presented on a 72 year-old woman with uncontrolled high blood pressure referred to the Urology Department due to the incidental finding of a right retroperitoneal mass. A functional and imaging study was performed, establishing a diagnosis of adrenal cyst causing hypertensive symptoms...
November 17, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/29157095/endothelial-autophagic-flux-hampers-atherosclerotic-lesion-development
#16
Marouane Kheloufi, Anne-Clemence Vion, Adel Hammoutene, Johanne Poisson, Juliette Lasselin, Cecile Devue, Isabelle Pic, Nicolas Dupont, Johanna Busse, Konstantin Stark, Julie Lafaurie-Janvore, Abdul I Barakat, Xavier Loyer, Michele Souyri, Benoit Viollet, Pierre Julia, Alain Tedgui, Patrice Codogno, Chantal M Boulanger, Pierre-Emmanuel Rautou
Blood flowing in arteries generates shear forces at the surface of the vascular endothelium that control its anti-atherogenic properties. However, due to the architecture of the vascular tree, these shear forces are heterogeneous and atherosclerotic plaques develop preferentially in areas where shear is low or disturbed. Here we review our recent study showing that elevated shear forces stimulate endothelial autophagic flux and that inactivating the endothelial macroautophagy/autophagy pathway promotes a pro-inflammatory, pro-senescent and pro-apoptotic cell phenotype despite the presence of atheroprotective shear forces...
November 20, 2017: Autophagy
https://www.readbyqxmd.com/read/29156466/-retinal-artery-occlusions
#17
Gabriele E Lang, Stefan J Lang
Retinal artery occlusions are acute vascular diseases. Very often they are caused by an embolisation. Rarely a thrombosis is caused by an arteriitis. In the acute phase diagnosis in most of the cases can be made by ophthalmoscopy due to the whitish retinal edema and in central retinal artery occlusion the cherry red spot. Difficulties in making the diagnosis can occur in the chronic stage, especially after reperfusion of the retinal vessels, when the fundus colour returned to normal again. Several diagnostic procedures help to make the diagnosis...
November 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29155160/%C3%AE-v%C3%AE-3-and-%C3%AE-5%C3%AE-1-integrin-specific-ligands-from-tumor-angiogenesis-inhibitors-to-vascularization-promoters-in-regenerative-medicine
#18
REVIEW
Luís A Rocha, David A Learmonth, Rui A Sousa, António J Salgado
Integrins are cell adhesion receptors predominantly important during normal and tumor angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg-Gly-Asp (RGD) has attracted attention due to its role in cell adhesion mediated by integrins. The development of ligands that can bind to integrins involved in tumor angiogenesis and brake disease progression has resulted in new investigational drug entities reaching the clinical trial phase in humans. The use of integrin-specific ligands can be useful for the vascularization of regenerative medicine constructs, which remains a major limitation for translation into clinical practice...
November 15, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/29154462/the-role-of-indoleamine-2-3-dioxygenase-in-normal-and-pathological-pregnancies
#19
REVIEW
Rui-Qi Chang, Da-Jin Li, Ming-Qing Li
The survival of allogeneic fetus during pregnancy contradicts the laws of immune responses. Behind this paradoxical phenomenon, the mechanism is quite complex. Indoleamine-2,3-dioxygenase (IDO) is the first and rate-limiting enzyme of tryptophan catabolism. Emerging evidence shows that IDO is expressed at the maternal-fetal interface, including trophoblast cells, decidual stroma cells, decidual immune cells (eg, natural killer cells, T cells, and macrophages), and vascular endothelial cells of decidua and chorion...
November 20, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29153690/time-course-of-angiotensin-ii-dependent-vascular-and-metabolic-effects-of-preeclampsia
#20
Paula Rosas, Cecilia Tufiño, Ismael Bracho Valdes, Rosa A Bobadilla Lugo
Pregnancy is characterized by a blunted pressor response to angiotensin II that is progressively lost during preeclampsia complicated pregnancies. Renin angiotensin system (RAS) plays a pivotal role in cardiovascular and renal function but its role in normal and pathological pregnancy is far from being clarified. It is not as clear if hypertension and particularly pregnancy-induced hypertension as the initial event, can trigger some of the metabolic syndrome components, and if these changes are angiotensin II mediated...
October 2017: Pregnancy Hypertension
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