keyword
https://read.qxmd.com/read/38493318/transplant-renal-artery-stenosis-a-case-report-and-literature-review
#1
JOURNAL ARTICLE
Nasser Simforoosh, Amirhossein Nayebzade, Meisam Ghaedi
Transplant renal artery stenosis is the most common vascular complication that turns out following kidney transplantation and can lead to graft dysfunction and even its loss. The present report, describes A patient with end-stage renal disease who underwent living related renal transplantation. He had oliguria and creatinine rise in the post-operative course but all doppler ultrasonography (DUS) during the 2 months post-operation for the renal graft showed a normal mean resistive index in the graft renal artery...
March 17, 2024: Urology Journal
https://read.qxmd.com/read/38492732/evaluation-of-hemodynamic-properties-after-chimney-and-fenestrated-endovascular-aneurysm-repair
#2
JOURNAL ARTICLE
Stavros Malatos, Laura Fazzini, Anastasios Raptis, Petroula Nana, George Kouvelos, Paola Tasso, Diego Gallo, Umberto Morbiducci, Michail A Xenos, Athanasios Giannoukas, Miltiadis Matsagkas
OBJECTIVES: Fenestrated (FEVAR) and chimney (ChEVAR) endovascular aortic repair have been applied in anatomically suitable complex aortic aneurysms. However, local hemodynamic changes may occur after repair. This study aimed to compare FEVAR's and ChEVAR's hemodynamic properties, focusing on visceral arteries. METHODS: Pre- and post-operative computed tomography angiographies (CTAs) have been used to reconstruct patient-based models. Data of three patients, for each modality, were analyzed...
March 14, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38491833/ultrasound-guided-percutaneous-high-frequency-irreversible-electroporation-in-porcine-livers-using-four-electrode-needles-a-feasibility-and-safety-study
#3
JOURNAL ARTICLE
Chang-Tian Li, Guo-Dong Zhao, Wen-Bo Zou, Zhen-Hua Zhang, Yi Zhao, Rong Liu
BACKGROUND: Malignant liver tumors seriously endanger human health. Among different therapeutic approaches, high-frequency irreversible electroporation (H-FIRE) is a recently emerging tumor ablation technique. The objective of this study was to evaluate the feasibility and safety of ultrasound-guided percutaneous H-FIRE using four electrode needles in porcine livers. METHODS: Twelve experimental pigs underwent percutaneous H-FIRE ablation using a compound steep-pulse therapeutic device...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491831/decreased-interleukin-17ra-expression-is-associated-with-good-prognosis-in-patients-with-colorectal-cancer-and-inhibits-tumor-growth-and-vascularity-in-mice
#4
JOURNAL ARTICLE
Jeng-Kai Jiang, Chi-Hung Lin, Ting-An Chang, Liang-Chuan Lo, Chien-Ping Lin, Ruey-Hwa Lu, Chih-Yung Yang
BACKGROUND: Interleukin-17 (IL-17) is a pro-inflammatory cytokine that plays a vital role in the promotion of tumorigenesis in various cancers, including colorectal cancer (CRC). Based on current evidence, IL-17 binds to interleukin-17 receptor A (IL-17RA); however, the role of IL-17RA has not been elucidated in previous studies on CRC. In this study, we explored the role of IL-17RA in human CRC tissues and the progression of CRC in humans and mice. METHODS: The expressions of IL-17RA and epithelial-mesenchymal transition (EMT)-related genes were examined in CRC cells and tissue samples by quantitative real-time polymerase chain reaction...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491429/the-association-between-inflammation-arterial-stiffness-oxidized-ldl-and-cardiovascular-disease-in-finnish-men-with-metabolic-syndrome-a-15-year-follow-up-study
#5
JOURNAL ARTICLE
Harri Juhani Saarinen, Jorma Lahtela, Päivi Mähönen, Ari Palomäki
BACKGROUND: All-cause mortality and cardiovascular disease are increased in subjects with metabolic syndrome (MetS). Risk scores are used to predict individual risk of heart disease. We performed a long-term follow-up study to investigate whether risk scores and cardiovascular risk factors such as arterial stiffness, high-sensitive C-reactive protein (hs-CRP) and oxidized LDL (OxLDL) can be used to predict cardiovascular events in Finnish men with MetS. METHODS: After baseline measurements we followed 105 Finnish men aged 30 to 65 years with MetS for a mean period of 16...
March 15, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38491143/clinical-report-of-microsurgical-treatment-of-kohler-s-disease
#6
JOURNAL ARTICLE
Yantao Pei, Lei Zhu, Qingjia Xu, Juntao Wang, Yuliang Sun, Gang Wang
The conservative treatment for Kohler's disease will take several months, but some patients still have flatfoot and persistent pain. From October 2013 to July 2015, 3 children with Kohler's disease underwent navicular decompression and micro-circulation reconstruction surgery in our hospital. All the patients have received conservative treatment for more than 3 months and the effect was poor. X-ray showed the bone density of navicular increased significantly. All patients were followed up over 1 year...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490900/diagnosis-and-management-of-vasoplegia-in-temporary-mechanical-circulatory-support-a-narrative-review
#7
REVIEW
Jamel Ortoleva, Adam A Dalia, Dominic V Pisano, Alexander Shapeton
Refractory vasodilatory shock, or vasoplegia, is a pathophysiologic state observed in the intensive care unit and operating room in patients with a variety of primary diagnoses. Definitions of vasoplegia vary by source but are qualitatively defined clinically as a normal or high cardiac index and low systemic vascular resistance causing hypotension despite high-dose vasopressors in the setting of euvolemia. This definition can be difficult to apply to patients undergoing mechanical circulatory support (MCS)...
February 23, 2024: Journal of Cardiothoracic and Vascular Anesthesia
https://read.qxmd.com/read/38490890/biomimetic-hepatic-lobules-from-three-dimensional-imprinted-cell-sheets
#8
JOURNAL ARTICLE
Jinglin Wang, Danqing Huang, Hanxu Chen, Yuanjin Zhao
Liver-tissue engineering has proven valuable in treating liver diseases, but the construction of liver tissues with high fidelity remains challenging. Here, we present a novel three-dimensional (3D)-imprinted cell-sheet strategy for the synchronous construction of biomimetic hepatic microtissues with high accuracy in terms of cell type, density, and distribution. To achieve this, the specific composition of hepatic cells in a normal human liver was determined using a spatial proteogenomics dataset. The data and biomimetic hepatic micro-tissues with hexagonal hollow cross-sections indicate that cell information was successfully generated using a homemade 3D-imprinted device for layer-by-layer imprinting and assembling the hepatic cell sheets...
February 28, 2024: Science Bulletin
https://read.qxmd.com/read/38490537/thromboelastography-with-platelet-mapping-identifies-high-platelet-reactivity-is-associated-with-obesity-diabetes-and-thrombotic-events
#9
JOURNAL ARTICLE
Ryan Hall, Sasha Suarez, Monica Majumdar, Ivy Lee, Nikolaos Zacharias, Denise Gee, Anahita Dua
OBJECTIVE: Identify prothrombotic coagulation profiles associated with diabetes and obesity using Thromboelastography SUMMARY BACKGROUND DATA: Metabolic comorbidities such as diabetes and obesity are considered pro-inflammatory states which theoretically increase the risk of perioperative thrombotic events across many surgical disciplines. Currently, there is a paucity of objective metrics to determine such risk and ideal pharmacologic targets. Thromboelastography with Platelet Mapping (TEG-PM) provides a comprehensive profile of coagulation and may provide insight into clot dysregulation...
March 13, 2024: Annals of Vascular Surgery
https://read.qxmd.com/read/38490095/a-longitudinal-and-cross-sectional-study-of-placental-circulation-between-normal-and-placental-insufficiency-pregnancies
#10
JOURNAL ARTICLE
J Y Chen, B L Yu, X J Wu, Y F Li, L Y Zhong, M Chen
INTRODUCTION: To longitudinally and cross-sectionally study the differences in the uterine artery pulsatility index (UTPI), umbilical artery pulsatility index (UAPI) and placental vascularization indices (PVIs, derived from 3-dimensional power Doppler) between normal and placental insufficiency pregnancies throughout gestation. METHODS: UTPI, UAPI and PVI were measured 6 times at 4- to 5- week intervals from 11 to 13+6 weeks-36 weeks. Preeclampsia (PE) and fetal growth restriction (FGR) were defined as placental insufficiency...
March 11, 2024: Placenta
https://read.qxmd.com/read/38489699/gynura-segetum-induces-hepatic-sinusoidal-obstruction-syndrome-in-a-child-a-case-report
#11
JOURNAL ARTICLE
Qian Zheng, Haiyang Zhang
RATIONALE: Hepatic sinusoidal obstruction syndrome (HSOS), which includes hepatic stasis and portal hypertension, is a rare vascular disorder of the liver. It is often associated with hematopoietic stem cell transplantation. It is also possible to treat this disease using Chinese herbal medicines that contain pyrrolizidine alkaloids (PAs). This disease is extremely rare in children and poses a serious threat to their health. To our knowledge, this is the first case of HSOS in a child with PAs...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38488667/down-regulating-lncrna-kcnq1ot1-relieves-type-ii-alveolar-epithelial-cell-apoptosis-during-one-lung-ventilation-via-modulating-mir-129-5p-hmgb1-axis-induced-pulmonary-endothelial-glycocalyx
#12
JOURNAL ARTICLE
Zhenghuan Song, Zhongqiu Wang, Jiaqin Cai, Yihu Zhou, Yueyi Jiang, Jing Tan, Lianbin Gu
OBJECTIVE: Endothelial glycocalyx (EG) maintains vascular homeostasis and is destroyed after one-lung ventilation (OLV)-induced lung injury. Long noncoding RNAs (lncRNAs) are critically involved in various lung injuries. This study aimed to investigate the role and regulatory mechanism of KCNQ1 overlapping transcript 1 (KCNQ1OT1) in OLV-induced lung injury and LPS-induced type II alveolar epithelial cell (AECII) apoptosis. METHODS: The rat OLV model was established, and the effects of KCNQ1OT1 on OLV-induced ALI in vivo were explored...
March 15, 2024: Environmental Toxicology
https://read.qxmd.com/read/38486977/phosphodiesterases-mediate-the-augmentation-of-myogenic-constriction-by-inhibitory-g-protein-signaling-and-is-negatively-modulated-by-the-dual-action-of-rgs2-and-5
#13
JOURNAL ARTICLE
Bo Sun, Nia Smith, Alethia J Dixon, Patrick Osei-Owusu
G protein regulation by regulators of G protein signaling (RGS) proteins play a key role in vascular tone maintenance. The loss of Gi/o and Gq/11 regulation by RGS2 and RGS5 in non-pregnant mice is implicated in augmented vascular tone and decreased uterine blood flow (UBF). RGS2 and 5 are closely related and co-expressed in uterine arteries (UA). However, whether and how RGS2 and 5 coordinate their regulatory activities to finetune G protein signaling and regulate vascular tone are unclear. Here, we determined how the integrated activity of RGS2 and 5 modulates vascular tone to promote UBF...
2024: Function
https://read.qxmd.com/read/38486060/unveiling-the-impact-of-hemodynamics-on-endothelial-inflammation-mediated-hepatocellular-carcinoma-metastasis-using-a-biomimetic-vascular-flow-model
#14
JOURNAL ARTICLE
Jia He, Peiyan Duan, Yi Liu, Tang Feng, Shuo Wang, Xinyi Lin, Jing Xie, Xiaoheng Liu
Distant metastasis of hepatocellular carcinoma (HCC) mediated by hematogenous dissemination is a leading cause of HCC-related deaths. The inflammatory response of vascular endothelial cells facilitates this process by promoting the adhesion and invasion of tumor cells in the circulatory system. While the regulation of this inflammation-mediated metastasis through upregulation of adhesion molecules and disruption of intercellular junctions has been well established, the contribution of hemodynamics to this process remains poorly understood due to the lack of a suitable vascular flow model for investigation...
March 14, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38485071/evaluating-growth-patterns-of-abdominal-aortic-aneurysms-among-women
#15
JOURNAL ARTICLE
Kathryn DiLosa, Gregory Brittenham, Cara Pozolo, Nasim Hedayati, Mimmie Kwong, Steven Maximus, Misty Humphries
OBJECTIVES: Though initially protected from vessel dilation by estrogen, women may experience rapid abdominal aortic aneurysm (AAA) growth post-menopause. The rate of growth has been poorly defined in prior literature. Here we describe aneurysm growth in a cohort of women found through an AAA screening program. METHODS: Women with AAA were retrospectively identified. Aortic imaging was reviewed, and measurements of maximum transverse and anterior-posterior diameters were completed...
March 12, 2024: Journal of Vascular Surgery
https://read.qxmd.com/read/38484963/vascular-health-years-after-a-hypertensive-disorder-of-pregnancy-the-epoch-study
#16
JOURNAL ARTICLE
Hayley E Miller, Seda Tierney, Marcia L Stefanick, Jonathan A Mayo, Oshra Sedan, Lisa G Rosas, Mads Melbye, Heather A Boyd, David K Stevenson, Gary M Shaw, Virginia D Winn, Mark A Hlatky
BACKGROUND: Preeclampsia is associated with a two-fold increase in a woman's lifetime risk of developing atherosclerotic cardiovascular disease (ASCVD), but the reasons for this association are uncertain. The objective of this study was to examine the associations between vascular health and a hypertensive disorder of pregnancy among women ≥ 2 years postpartum. METHODS: Pre-menopausal women with a history of either a hypertensive disorder of pregnancy (cases: preeclampsia or gestational hypertension) or a normotensive pregnancy (controls) were enrolled...
March 12, 2024: American Heart Journal
https://read.qxmd.com/read/38482942/effects-of-edaravone-on-testicular-torsion-detorsion-injury-in-rats
#17
JOURNAL ARTICLE
Yaşar Şahin, Evren Üstüner, Hidayet Tutun, Ebru Yildirim, Oğuz Eroğlu, Efe Kurtdede, Yasin Ozkabadayi, Enes Güncüm, Kürşat Kutluca, Ahmet Bilgehan Bilge
BACKGROUND AND OBJECTIVE: This study aimed to assess the protective ability of edaravone on testicular torsion-detorsion injury in rats. METHODS: Eighteen adult male Sprague-Dawley rats were randomly divided into three groups: Sham group (control, n = 6); testicular torsion/detorsion (T/D group, n = 6) and T/D+edaravone (T/D+E group, n = 6). The spermatic cords of rats of the T/D group and the T/D+E group were rotated 720° in a clockwise direction and maintained for 120 min in this torsion position...
March 14, 2024: Andrology
https://read.qxmd.com/read/38482387/automated-valvular-heart-disease-detection-using-heart-sound-with-a-deep-learning-algorithm
#18
JOURNAL ARTICLE
Zihan Jiang, Wenhua Song, Yonghong Yan, Ao Li, Yujing Shen, Shouda Lu, Tonglian Lv, Xinmu Li, Ta Li, Xueshuai Zhang, Xun Wang, Yingjie Qi, Wei Hua, Min Tang, Tong Liu
BACKGROUND: Insufficient clinicians' auscultation ability delays the diagnosis and treatment of valvular heart disease (VHD); artificial intelligence provides a solution to compensate for the insufficiency in auscultation ability by distinguishing between heart murmurs and normal heart sounds. However, whether artificial intelligence can automatically diagnose VHD remains unknown. Our objective was to use deep learning to process and compare raw heart sound data to identify patients with VHD requiring intervention...
April 2024: IJC Heart & Vasculature
https://read.qxmd.com/read/38482230/management-and-mechanism-of-calciphylaxis-in-a-patient-treated-with-the-fgfr-inhibitor-pemigatinib-a-case-report
#19
Sreenivasa R Chandana, Austin Frisch, Sergio Mendoza, Ranu S Sinniah, Oxana Crysler, Ramandeep Banga, Diane E Perkins
BACKGROUND: Small molecule fibroblast growth factor receptor (FGFR) inhibitors, such as pemigatinib, have been developed for the treatment of cholangiocarcinoma (CCA) with rearrangements or fusions in the FGFR2. FGFR inhibitors (FGFRis) have dermatologic side effects such as dry skin or nail bed damage. However, in very rare instances, a life-threatening vascular calcification disease known as calciphylaxis has been linked to these therapies. CASE DESCRIPTION: We report a patient with metastatic CCA, who developed calciphylaxis following the start of their pemigatinib treatment...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38481281/nitric-oxide-nano-reactor-dnmf-plga-enables%C3%A2-tumor-vascular-microenvironment-and-chemo-hyperthermia-synergetic-therapy
#20
JOURNAL ARTICLE
Ruoyao Wang, Long Cheng, Lingyun He, Chier Du, Haiyang Wang, Bohao Peng, Xiaoqing Yu, Weiwei Liu, Wenpei Luo, Haitao Ran, Lu Yang
BACKGROUND: Breast cancer ranks first among malignant tumors, of which triple-negative breast cancer (TNBC) is characterized by its highly invasive behavior and the worst prognosis. Timely diagnosis and precise treatment of TNBC are substantially challenging. Abnormal tumor vessels play a crucial role in TNBC progression and treatment. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis, while effective NO delivery can normalize the tumor vasculature. Accordingly, we have proposed here a tumor vascular microenvironment remodeling strategy based on NO-induced vessel normalization and extracellular matrix collagen degradation with multimodality imaging-guided nanoparticles against TNBC called DNMF/PLGA...
March 13, 2024: Journal of Nanobiotechnology
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