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Asthma in pregnancy

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https://www.readbyqxmd.com/read/28712803/maternal-asthma-severity-and-control-during-pregnancy-and-risk-of-offspring-asthma
#1
Xiaoqin Liu, Esben Agerbo, Vivi Schlünssen, Rosalind J Wright, Jiong Li, Trine Munk-Olsen
BACKGROUND: Severe and uncontrolled asthma during pregnancy has been linked to several unfavorable perinatal outcomes. However, current knowledge on the association between the severity and control of maternal asthma and offspring asthma is sparse. OBJECTIVE: We sought to investigate the extent to which offspring asthma is influenced by maternal asthma severity and control during pregnancy. METHODS: We performed a prospective population-based cohort study...
June 27, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28706087/periconception-endogenous-and-exogenous-maternal-sex-steroid-hormones-and-risk-of-asthma-and-allergy-in-offspring-protocol-for-a-systematic-review-and-meta-analysis
#2
Merhunisa Talovic, Aziz Sheikh, Nicola McCleary, Maijaliisa Erkkola, Minna Kaila, Suvi M Virtanen, Bright I Nwaru
INTRODUCTION: Pregnancy is associated with several hormonal changes which influence the developing fetus. Variations in maternal endogenous hormones and prepregnancy use of hormonal preparations have been linked to asthma and allergy in the offspring, but findings are inconsistent. We plan to undertake a systematic review to synthesise the evidence on the association between endogenous and exogenous maternal sex hormones and the risk of asthma and allergy in the offspring. METHODS AND ANALYSIS: We will search Medline, Embase, Cochrane Library, Institute of Scientific Information Web of Science, Cumulative Index of Nursing and Allied Health, Scopus, Google Scholar, Allied and Complementary Medicine Database, Global Health, Psychological Information (PsycINFO), Centre for Agriculture and Bioscience (CAB) International and WHO Global Health Library from inception until 2016 to identify relevant studies on the topic...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28694101/fish-oil-supplementation-during-pregnancy-may-reduce-risk-of-persistent-wheeze-or-asthma-in-children-in-first-five-years-of-life
#3
Daniel A Ostrovsky
No abstract text is available yet for this article.
April 21, 2017: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/28684711/chronic-and-acute-ozone-exposure-in-the-week-prior-to-delivery-is-associated-with-the-risk-of-stillbirth
#4
Pauline Mendola, Sandie Ha, Anna Z Pollack, Yeyi Zhu, Indulaxmi Seeni, Sung Soo Kim, Seth Sherman, Danping Liu
Chronic and acute air pollution has been studied in relation to stillbirth with inconsistent findings. We examined stillbirth risk in a retrospective cohort of 223,375 singleton deliveries from 12 clinical sites across the United States. Average criteria air pollutant exposure was calculated using modified Community Multiscale Air Quality models for the day of delivery and each of the seven days prior, whole pregnancy, and first trimester. Poisson regression models using generalized estimating equations estimated the relative risk (RR) of stillbirth and 95% confidence intervals (CI) in relation to an interquartile range increase in pollutant with adjustment for temperature, clinical, and demographic factors...
July 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28684535/sugar-intake-in-pregnancy-is-linked-to-child-s-allergy-and-allergic-asthma
#5
Ingrid Torjesen
No abstract text is available yet for this article.
July 6, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28683663/using-fathers-as-a-negative-control-exposure-to-test-the-developmental-origins-of-health-and-disease-hypothesis-a-case-study-on-maternal-distress-and-offspring-asthma-using-swedish-register-data
#6
Bronwyn K Brew, Tong Gong, Dylan M Williams, Henrik Larsson, Catarina Almqvist
BACKGROUND: Developmental Origins of Health and Disease Hypothesis (DOHaD) studies are often observational in nature and are therefore prone to biases from loss to follow-up and unmeasured confounding. Register-based studies can reduce these issues since they allow almost complete follow-up and provide information on fathers that can be used in a negative control analysis to assess the impact of unmeasured confounding. AIM: The aim of this study was to propose a causal model for testing DOHaD using paternal exposure as a negative control, and its application to maternal distress in pregnancy and offspring asthma...
July 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28679610/maternal-intake-of-sugar-during-pregnancy-and-childhood-respiratory-and%C3%A2-atopic-outcomes
#7
Annabelle Bédard, Kate Northstone, A John Henderson, Seif O Shaheen
The possible role of maternal consumption of free sugar during pregnancy in the inception of respiratory and atopic diseases has not been studied. We aimed to study the relationship between maternal intake of free sugar during pregnancy and respiratory and atopic outcomes in the offspring in a population-based birth cohort, the Avon Longitudinal Study of Parents and Children.We analysed associations between maternal intake of free sugar in pregnancy (estimated by a food frequency questionnaire), and current doctor-diagnosed asthma, wheezing, hay fever, eczema, atopy, serum total IgE and lung function in children aged 7-9 years (n=8956 with information on maternal diet in pregnancy and at least one outcome of interest)...
July 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28661182/prenatal-nitrate-exposure-and-childhood-asthma-influence-of-maternal-prenatal-stress-and-fetal-sex
#8
Sonali Bose, Yueh-Hsiu M Chiu, Hsiao-Hsien L Hsu, Qian Di, Maria José Rosa, Alison Lee, Itai Kloog, Ander Wilson, Joel Schwartz, Robert O Wright, Sheldon Cohen, Brent A Coull, Rosalind J Wright
RATIONALE: Impact of ambient pollution upon children's asthma may differ by sex, and exposure dose and timing. Psychosocial stress can also modify pollutant effects. These associations have not been examined for in utero ambient nitrate exposure. OBJECTIVES: We implemented Bayesian distributed lag interaction models (BDLIMs), to identify sensitive prenatal windows for the influence of NO3- on child asthma, accounting for effect modification by sex and stress. METHODS: Analyses included 752 mother-child dyads...
June 29, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28635579/-fish-oil-in-pregnancy-can-it-prevent-asthma-in-children
#9
P L P Brand, M B Katan
Taking fish oil supplements in the third trimester of pregnancy was associated with significantly less wheezing or asthma in the child at the age of 3-5 years, according to a randomized clinical trial by Bisgaard et al., NEJM 2017. However, the results of this study should be interpreted with caution. The primary end points were modified at a late stage in the study, and two primary end points, eczema in the first 3 years of life and allergic sensitization at 18 months of age, were demoted to secondary end points, and showed no significant effect of treatment...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28632934/a-prospective-microbiome-wide-association-study-of-food-sensitization-and-food-allergy-in-early-childhood
#10
Jessica H Savage, Kathleen A Lee-Sarwar, Joanne Sordillo, Supinda Bunyavanich, Yanjiao Zhou, George O'Connor, Megan Sandel, Leonard Bacharier, Robert Zeiger, Erica Sodergren, George M Weinstock, Diane R Gold, Scott T Weiss, Augusto A Litonjua
BACKGROUND: Alterations in the intestinal microbiome are prospectively associated with the development of asthma; less is known regarding the role of microbiome alterations in food allergy development. METHODS: Intestinal microbiome samples were collected at age 3-6 months in children participating in the follow-up phase of an interventional trial of high dose Vitamin D given during pregnancy. At age 3, sensitization to foods (milk, egg, peanut, soy, wheat, walnut) was assessed...
June 20, 2017: Allergy
https://www.readbyqxmd.com/read/28606587/asthma-control-status-in-pregnancy-bmi-and-maternal-vitamin-d-levels
#11
Hooman Mirzakhani, George O'Connor, Leonard B Bacharier, Robert S Zeiger, Michael X Schatz, Scott T Weiss, Augusto A Litonjua
Higher maternal 25OHD levels at early pregnancy could reduce the associated risk of uncontrolled asthma status during pregnancy. Obesity might attenuate this effect and is a predictor of uncontrolled status during pregnancy.
June 9, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28601684/b-cells-control-maternofetal-priming-of-allergy-and-tolerance-in-a-murine-model-of-allergic-airway-inflammation
#12
Christine Happle, Adan Chari Jirmo, Almut Meyer-Bahlburg, Anika Habener, Heinz Gerd Hoymann, Christian Hennig, Jelena Skuljec, Gesine Hansen
BACKGROUND: Allergic asthma is a chronic lung disease resulting from inappropriate immune responses to environmental antigens. Early tolerance induction is an attractive approach for primary prevention of asthma. OBJECTIVE: We analysed the mechanisms of perinatal tolerance induction to allergens with particular focus on the role of B cells in preconceptional and early intrauterine immune priming. METHODS: Wild type (WT) and B cell deficient mice received ovalbumin (OVA) intranasally before mating...
June 7, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28601048/maternal-asthma-pregnancy-delivery-and-birth-outcomes-a-retrospective-cohort-study
#13
Atefeh Vaezi, Ladan Haghighi, Farzaneh Beigmohammadi, Marzieh Nojomi
The aim of current study was to determine women´s maternal asthma in pregnancy, delivery and birth outcomes. Using a retrospective cohort design, data of 580 pregnant women were gathered form a large teaching hospital in Tehran, Iran. The medical records of pregnant women who had attended this hospital between 2009 and 2011 were assessed. Data of delivery and birth outcomes were gathered by observation and medical records of women. Multiple logistic regression and adjusted odds ratio (OR) were used to assess the independent association of asthma and outcomes...
April 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28596717/integration-of-metabolomic-and-transcriptomic-networks-in-pregnant-women-reveals-biological-pathways-and-predictive-signatures-associated-with-preeclampsia
#14
Rachel S Kelly, Damien C Croteau-Chonka, Amber Dahlin, Hooman Mirzakhani, Ann C Wu, Emily S Wan, Michael J McGeachie, Weiliang Qiu, Joanne E Sordillo, Amal Al-Garawi, Kathryn J Gray, Thomas F McElrath, Vincent J Carey, Clary B Clish, Augusto A Litonjua, Scott T Weiss, Jessica A Lasky-Su
INTRODUCTION: Preeclampsia is a leading cause of maternal and fetal mortality worldwide, yet its exact pathogenesis remains elusive. OBJECTIVES: This study, nested within the Vitamin D Antenatal Asthma Reduction Trial (VDAART), aimed to develop integrated omics models of preeclampsia that have utility in both prediction and in the elucidation of underlying biological mechanisms. METHODS: Metabolomic profiling was performed on first trimester plasma samples of 47 pregnant women from VDAART who subsequently developed preeclampsia and 62 controls with healthy pregnancies, using liquid-chromatography tandem mass-spectrometry...
January 2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28568319/narcolepsy-with-cataplexy-and-pregnancy-a-case-control-study
#15
Elena Calvo-Ferrandiz, Rosa Peraita-Adrados
This was a retrospective case-control study in 25 patients with narcolepsy with cataplexy and 75 women in the control group. Patients completed the questionnaire by Maurovich-Horvat et al. (J. Sleep Res., 2013, 22: 496-512). We personally interviewed 25 patients with narcolepsy with cataplexy using the administered questionnaire regarding conception, pregnancy, delivery, perinatal and breastfeeding periods. Patients with narcolepsy with cataplexy reported 59 pregnancies versus 164 in the control group. In 16 cases (27...
June 1, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28561251/management-of-acute-respiratory-failure-in-pregnancy
#16
Stephen E Lapinsky
Respiratory failure affects up to 1 in 500 pregnancies, more commonly in the postpartum period. The causes of respiratory failure include several pregnancy-specific conditions such as preeclampsia, amniotic fluid embolism, and peripartum cardiomyopathy. Pregnancy may also increase the risk or severity of other conditions, such as asthma, thromboembolism, viral pneumonitis, and gastric acid aspiration. Changes to maternal respiratory physiology and the presence of a fetus may affect the assessment and management of these patients...
April 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28561247/asthma-during-pregnancy-exacerbations-management-and-health-outcomes-for-mother-and-infant
#17
Vanessa E Murphy, Megan E Jensen, Peter G Gibson
One in 10 pregnant women worldwide has asthma and of these, 10% will have a severe exacerbation requiring oral corticosteroids (OCSs) in pregnancy. This review of recent publications in the field will describe the effects of exacerbation on maternal and neonatal health, the use of asthma medications during pregnancy, and will suggest novel management approaches for asthma in pregnancy. Pregnancy results in unpredictable changes in the disease; therefore, regular monitoring of symptoms is recommended. Uncontrolled asthma is frequently described in cohorts of pregnant women with asthma, and some recent studies show associations with adverse perinatal outcomes, as previously demonstrated with exacerbations...
April 2017: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28559916/maternal-sensitivity-and-social-support-protect-against-childhood-atopic-dermatitis
#18
Nicole L Letourneau, Anita L Kozyrskyj, Nela Cosic, Henry N Ntanda, Lubna Anis, Martha J Hart, Tavis S Campbell, Gerald F Giesbrecht
BACKGROUND: Many studies have identified associations between qualities of maternal-child relationships and childhood asthma, but few have examined associations with childhood atopic dermatitis (AD), a common precursor to asthma. Moreover, maternal psychological distress, including prenatal and postnatal depression, anxiety and stress, may increase risk, while social support from partners may reduce risk for childhood AD. We sought to uncover the association between maternal-infant relationship qualities (maternal sensitivity towards infant behavioral signals, controlling behavior, and unresponsiveness) and child AD after accounting for risk (i...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28552588/vitamin-d-supplementation-during-pregnancy-effect-on-the-neonatal-immune-system-in-a-randomized-controlled-trial
#19
Eve Hornsby, Paul E Pfeffer, Nancy Laranjo, William Cruikshank, Marina Tuzova, Augusto A Litonjua, Scott T Weiss, Vincent J Carey, George O'Connor, Catherine Hawrylowicz
BACKGROUND: Programming of the immune system during fetal development can influence asthma-related risk factors and outcomes in later life. Vitamin D is a well-recognized immune modulator, and deficiency of this nutrient during pregnancy is hypothesized to influence disease development in offspring. OBJECTIVE: We sought to investigate the effect on neonatal immunity of maternal supplementation with 4400 IU/d vitamin D3 during the second and third trimesters of pregnancy by using a subset of cord blood samples from a randomized, double-blind, placebo-controlled clinical trial (the Vitamin D Antenatal Asthma Reduction Trial)...
May 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28552381/influence-of-maternal-body-mass-index-and-macrophage-activation-on-asthma-exacerbations-in-pregnancy
#20
Vanessa E Murphy, Megan E Jensen, Heather Powell, Peter G Gibson
BACKGROUND: Obesity is a risk factor for exacerbations of asthma, but the mechanisms of this effect in pregnancy are unknown. OBJECTIVE: This study determined the influence of maternal body mass index, gestational weight gain, eosinophilic inflammation, and systemic macrophage activation on the risk of exacerbations during pregnancy. METHODS: Women with asthma (n = 164) participated in the study. Body mass index recorded at baseline (17 weeks gestation) was categorized as healthy weight (18...
May 25, 2017: Journal of Allergy and Clinical Immunology in Practice
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