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Asthma in pregnancy

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https://www.readbyqxmd.com/read/29905403/25-hydroxyvitamin-d-and-health-service-utilization-for-asthma-in-early-childhood
#1
Jessica A Omand, Teresa To, Deborah L O'Connor, Patricia C Parkin, Catherine S Birken, Kevin E Thorpe, Jonathon L Maguire
BACKGROUND: Asthma is the most common chronic illness of childhood and a common reason for hospital admission. Studies suggest that low vitamin D levels may be associated with health service utilization (HSU) for childhood asthma. The primary objective was to determine if vitamin D serum levels in early childhood were associated with HSU for asthma including: a) hospital admissions; b) emergency department visits; and c) outpatient sick visits. Secondary objectives were to determine whether vitamin D supplementation in pregnancy or childhood were associated with HSU for asthma...
June 15, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29902162/youth-risk-behavior-surveillance-united-states-2017
#2
Laura Kann, Tim McManus, William A Harris, Shari L Shanklin, Katherine H Flint, Barbara Queen, Richard Lowry, David Chyen, Lisa Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, Nancy Brener, Kathleen A Ethier
PROBLEM: Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults in the United States. In addition, significant health disparities exist among demographic subgroups of youth defined by sex, race/ethnicity, and grade in school and between sexual minority and nonsexual minority youth. Population-based data on the most important health-related behaviors at the national, state, and local levels can be used to help monitor the effectiveness of public health interventions designed to protect and promote the health of youth at the national, state, and local levels...
June 15, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29882296/influence-of-genetic-variants-on-childhood-lung-functionthe-generation-r-study
#3
REVIEW
Sara Shagiwal, Herman T den Dekker, Johan C de Jongste, Guy G Brusselle, Vincent W V Jaddoe, Janine F Felix, Liesbeth Duijts
BACKGROUND: Genetic variants associated with adult lung function could already exert effects in childhood lung function. We aimed to examine the associations of adult lung function-related genetic variants with childhood lung function and asthma, and whether these associations were modified by atopic predisposition, tobacco smoke exposure, or early growth characteristics. METHODS: In a population-based prospective cohort study among 3,347 children, we selected 7 and 20 SNPs associated with adult forced expiratory volume in 1 second (FEV1 ) and FEV1 /forced vital capacity (FEV1 /FVC), respectively...
June 7, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29880541/maternal-age-at-delivery-lung-function-and-asthma-in-offspring-a-population-based-survey
#4
Francisco Gómez Real, John A Burgess, Simona Villani, Julia Dratva, Joachim Heinrich, Christer Janson, Debbie Jarvis, Jennifer Koplin, Bénédicte Leynaert, Caroline Lodge, Birger N Lærum, Melanie C Matheson, Dan Norbäck, Ernst R Omenaas, Svein M Skulstad, Jordi Sunyer, Shyamali C Dharmage, Cecilie Svanes
There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex.10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years...
June 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29879703/the-aaa-risk-factors-scale-a-new-model-to-screen-for-the-risk-of-asthma-allergic-rhinitis-and-atopic-dermatitis-in-children
#5
Souheil Hallit, Chantal Raherison, Diana Malaeb, Rabih Hallit, Nelly Kheir, Pascale Salameh
OBJECTIVE: To create an allergic disease risk factors scale score that would screen for the risk assessment of asthma, allergic rhinitis and atopic dermatitis in children from 3-17 years. METHODS: This case-control study, conducted between December 2015 and April 2016, enrolled 1274 children. The allergic disease risk factors scale was created by combining environmental, exposure to toxics during pregnancy and breastfeeding and parental history of allergic diseases...
June 7, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29863910/maternal-cytokine-profiles-during-pregnancy-predict-asthma-in-children-of-nonasthmatic-mothers
#6
Janet Rothers, Debra A Stern, I Carla Lohman, Amber Spangenberg, Anne L Wright, Avery DeVries, Donata Vercelli, Marilyn Halonen
Little is known about whether maternal immune status during pregnancy influences asthma development in the child. We measured cytokine production in supernatants from mitogen-stimulated peripheral blood immune cells collected during and after pregnancy from the mothers of children enrolled in the Tucson Infant Immune Study, a non-selected birth cohort. Physician-diagnosed active asthma in children through age 9 and a history of asthma in their mothers were assessed through questionnaires. Maternal production of each of the cytokines IL-13, IL-4, IL-5, IFN-γ, IL-10, and IL-17 during pregnancy was unrelated to childhood asthma...
June 4, 2018: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29806178/airway-function-in-infancy-is-linked-to-airflow-measurements-and-respiratory-symptoms-from-childhood-into-adulthood
#7
Louisa Owens, Ingrid A Laing, Guicheng Zhang, Steve Turner, Peter N Le Souëf
INTRODUCTION: Increasing evidence suggests that poor lung function in adulthood is determined very early in life. Our study aims were: (1) identify factors associated with early infant lung function; (2) quantify the link between early infant lung function and early adult lung function; and (3) identify environmental and inherited factors which predict lung function throughout the post-natal growth period. METHODS: In this longitudinal study, 253 individuals were recruited antenatally...
May 27, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29797075/prospective-cohort-study-of-pregnancy-complications-and-birth-outcomes-in-women-with-asthma
#8
Nasrin Fazel, Michael Kundi, Erika Jensen-Jarolim, Isabella Pali-Schöll, Asghar Kazemzadeh, Mojtaba Fattahi Abdizadeh, Habibollah Esmaily, Roya Akbarzadeh, Raheleh Ahmadi
BACKGROUND: Asthma is the most common potentially serious medical complication in pregnancy. The purpose of this study was to determine the association between maternal asthma and a spectrum of adverse neonatal and maternal outcomes. METHODS: Events during pregnancy and birth outcome were evaluated in 34 asthmatic as well as 1569 non-asthmatic pregnant women who were enrolled in a prospective cohort study undertaken at the antenatal clinics of Mobini Hospital in Iran...
May 24, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29785060/cost-effectiveness-of-vitamin-c-supplementation-for-pregnant-smokers-to-improve-offspring-lung-function-at-birth-and-reduce-childhood-wheeze-asthma
#9
Leah Yieh, Cindy T McEvoy, Scott W Hoffman, Aaron B Caughey, Kelvin D MacDonald, Dmitry Dukhovny
OBJECTIVE: To determine the implications of supplemental vitamin C for pregnant tobacco smokers and its effects on the prevalence of pediatric asthma, asthma-related mortality, and associated costs. STUDY DESIGN: A decision-analytic model built via TreeAge compared the outcome of asthma in a theoretical annual cohort of 480,000 children born to pregnant smokers through 18 years of life. Vitamin C supplementation (500 mg/day) with a standard prenatal vitamin was compared to a prenatal vitamin (60 mg/day)...
May 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29775476/maternal-asthma-is-associated-with-increased-risk-of-perinatal-mortality
#10
Mari Kemppainen, Anna-Maria Lahesmaa-Korpinen, Paula Kauppi, Martti Virtanen, Suvi M Virtanen, Riitta Karikoski, Mika Gissler, Turkka Kirjavainen
BACKGROUND: Asthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome. OBJECTIVES: Our goal was to assess the association between maternal asthma and the perinatal risks as well as possible effects of asthma medication. METHODS: The study was based on a nationwide Finnish register-based cohort between the years 1996 and 2012 in the Drug and Pregnancy Database. The register data comprised 962 405 singleton live and stillbirths, 898 333 (93...
2018: PloS One
https://www.readbyqxmd.com/read/29774708/-communicating-data-of-the-italian-ninfea-birth-cohort
#11
Lorenzo Richiardi, Maja Popovic, Daniela Zugna, Franca Rusconi, Franco Merletti, Costanza Pizzi
"In March 2016, the website of the NINFEA project (an Internet-based cohort set up to investigate the effects of exposures acting early in life) was enriched with the section «Data», which reports aggregated data for selected variables of the cohort. This article discusses the rationale for this new section, available data and their possible uses are described, and some results are compared with figures accessible from surveillance studies. The Italian birth cohort NINFEA includes 7,500 pregnant women, recruited through the Internet from 2005 to June 2016, and of their children, followed up with repeated questionnaires...
March 2018: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29762633/using-a-mixture-of-bivariate-regression-model-to-explore-heterogeneity-of-effects-of-use-of-inhaled-corticosteroids-on-gestational-age-and-birthweight-among-pregnant-women-with-asthma
#12
Mariia Samoilenko, Lucie Blais, Isabelle Boucoiran, Geneviève Lefebvre
Asthma is a heterogeneous disease, and responses to asthma medications vary noticeably among patients. A substantively oriented objective of this study was to explore the potential heterogeneous effects of maternal inhaled corticosteroids (ICS) exposure on gestational age (GA) at delivery and birthweight (BW) using a cohort of 6,197 pregnancies from women with asthma (Quebec, Canada, 1998-2008). A methodologically oriented objective was to comprehensively describe the application of a Bayesian two-component mixture of bivariate regressions to address this issue and estimate the effects of ICS on GA and BW jointly...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29758487/maternal-allergy-as-an-isolated-risk-factor-for-early-onset-preeclampsia-an-epidemiological-study
#13
Anne Kvie Sande, Erik Andreas Torkildsen, Ragnar Kvie Sande, Nils-Halvdan Morken
Immunological mechanisms underlying the development of preeclampsia are well known, but no association to allergy has yet been demonstrated. The aim of this study was to assess the correlation between maternal pre-gestational allergy, and early-onset and late-onset preeclampsia, respectively. It was a retrospective cohort study including all women giving birth in the Norwegian cities of Stavanger (1996-2014) and Bergen (2009-2014). Pre-gestational asthma, allergy, other known risk factors for preeclampsia, maternal age and parity were obtained from the electronic medical record system...
June 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29748248/bromodomain-protein-brd4-is-increased-in-human-placentas-from-women-with-early-onset-preeclampsia
#14
Stella Liong, Gillian Barker, Martha Lappas
Preeclampsia affects 5% of all pregnancies and is a serious disorder of pregnancy, characterised by high maternal blood pressure, placental hypoxia, fluid retention (oedema) and proteinuria. Women with preeclampsia are associated with exaggerated levels of pro-inflammatory cytokines, chemokines and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFLT1). Studies in non-gestational tissues have described the bromodomain (BRD) and extraterminal family of proteins, in particular BRD4 to play a critical role in propagating inflammation and is currently a therapeutic target for treating cancer, lung inflammation and asthma...
June 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29747656/maternal-drug-use-and-the-risk-of-anorectal-malformations-systematic-review-and-meta-analysis
#15
REVIEW
Nadine Zwink, Ekkehart Jenetzky
BACKGROUND: Origin of anorectal malformations (ARM) are considered multifactorial. Several genetic and non-genetic risk factors are discussed in literature. Maternal periconceptional medical drug use as possible risk factor, however, has not been reviewed systematically. METHODS: Studies published between 1977 and April 2017 were reviewed through systematic search in PubMed, ISI Web of Knowledge and Scopus databases. Furthermore, related and cross-referencing publications were reviewed...
May 10, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29737224/associations-between-childhood-biomedical-factors-maternal-smoking-personality-traits-body-and-mass-index-and-the-prevalence-of-asthma-in-adulthood
#16
Helen Cheng, Scott Montgomery, Luke Treglown, Adrian Furnham
OBJECTIVE: The study set out to investigate socio-economic, biomedical, health and behavioural and psychological factors in childhood and adulthood associated with the prevalence of asthma in adulthood, drawing data from The National Child Development Studies (NCDS), a birth cohort in the UK. DESIGN: The National Child Development Study, a nationally representative sample of 17,415 babies born in Great Britain in 1958 and followed up at 7, 11, 33 and 50 years was used...
May 8, 2018: Psychology & Health
https://www.readbyqxmd.com/read/29722838/vitamin-a-and-d-intake-in-pregnancy-infant-supplementation-and-asthma-development-the-norwegian-mother-and-child-cohort
#17
Christine L Parr, Maria C Magnus, Øystein Karlstad, Kristin Holvik, Nicolai A Lund-Blix, Margareta Haugen, Christian M Page, Per Nafstad, Per M Ueland, Stephanie J London, Siri E Håberg, Wenche Nystad
Background: Western diets may provide excess vitamin A, which is potentially toxic and could adversely affect respiratory health and counteract benefits from vitamin D. Objective: The aim of this study was to examine child asthma at age 7 y in relation to maternal intake of vitamins A and D during pregnancy, infant supplementation with these vitamins, and their potential interaction. Design: We studied 61,676 school-age children (born during 2002-2007) from the Norwegian Mother and Child Cohort with data on maternal total (food and supplement) nutrient intake in pregnancy (food-frequency questionnaire validated against biomarkers) and infant supplement use at age 6 mo (n = 54,142 children)...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29716412/trends-in-asthma-self-management-skills-and-inhaled-corticosteroid-use-during-pregnancy-and-postpartum-from-2004-to-2017
#18
Annelies L Robijn, Megan E Jensen, Peter G Gibson, Heather Powell, Warwick B Giles, Vicki L Clifton, Joerg Mattes, Michael J Peek, Helen L Barrett, Sean K Seeho, Leonie K Callaway, Alistair Abbott, John Attia, Peter A Wark, Vanessa E Murphy
OBJECTIVE: Asthma exacerbations and medication non-adherence are significant clinical problems during pregnancy. While asthma self-management education is effective, the number of education sessions required to maximise asthma management knowledge and inhaler technique and whether improvements persist postpartum, is unknown. This paper describes how asthma knowledge, skills, and inhaled corticosteroid (ICS) use have changed over time. METHODS: Data were obtained from three cohorts of pregnant women with asthma recruited in Newcastle, Australia between 2004-2017 (N = 895)...
May 2, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29714103/traffic-related-air-pollution-lung-function-and-host-vulnerability-new-insights-from-the-paris-birth-cohort
#19
Nicolas Bougas, Fanny Rancière, Nicole Beydon, Malika Viola, Xavier Perrot, Stephan Gabet, Guillaume Lezmi, Flore Amat, Jacques De Blic, Jocelyne Just, Isabelle Momas
RATIONALE: Although the effects of traffic-related air pollution on respiratory exacerbations have been well documented, its impact on lung function in childhood remains unclear. OBJECTIVES: Our aim was to investigate the associations of prenatal, early, and lifetime traffic-related air pollution exposure with lung function at 8-9 years studying possible effect modification by sex, sensitization at 8-9 years, and early lower respiratory tract infections. METHODS: We conducted this study among 788 children from the PARIS (Pollution and Asthma Risk: an Infant Study) birth cohort...
May 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29702689/wheezing-phenotypes-and-risk-factors-in-early-life-the-elfe-cohort
#20
Souheil Hallit, Benedicte Leynaert, Marie Christine Delmas, Steffi Rocchi, Jacques De Blic, Christophe Marguet, Emeline Scherer, Marie Noelle Dufourg, Corinne Bois, Gabriel Reboux, Laurence Millon, Marie Aline Charles, Chantal Raherison
OBJECTIVE: Different phenotypes of wheezing have been described to date but not in early life. We aim to describe wheezing phenotypes between the ages of two months and one year, and assess risk factors associated with these wheezing phenotypes in a large birth cohort. METHODS: We studied 18,041 infants from the ELFE (French Longitudinal Study of Children) birth cohort. Parents reported wheezing and respiratory symptoms at two and 12 months, and answered a complete questionnaire (exposure during pregnancy, parental allergy)...
2018: PloS One
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