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Asthma in pregnancy

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https://www.readbyqxmd.com/read/29219619/prenatal-and-early-life-fructose-fructose-containing-beverages-and-mid-childhood-asthma
#1
Lakiea S Wright, Sheryl L Rifas-Shiman, Emily Oken, Augusto A Litonjua, Diane R Gold
RATIONALE: Cross-sectional studies have linked intake of high fructose corn syrup sweetened beverages with asthma in school children. OBJECTIVE: To examine associations of maternal prenatal and early childhood intake of sugar sweetened beverages and fructose with current asthma in mid-childhood (median 7.7years). METHODS: We assessed maternal pregnancy (1st and 2nd trimester average) and child (median 3.3years) intake of sugar sweetened beverages and total fructose using food frequency questionnaires in 1068 mother-child pairs from Project Viva, a prospective pre-birth cohort...
December 8, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29211611/pregnancy-associated-plasma-protein-a-papp-a-levels-in-patients-with-severe-allergic-asthma-are-reduced-by-omalizumab
#2
Ismet Bulut, Zeynep F Ozseker, Abdurrahman Coskun, Mustafa Serteser, Ibrahim Unsal
BACKGROUND: Remodeling is a crucial feature of severe asthma and may be associated with activation of the allergic cascade by immunoglobulin E (IgE). Omalizumab, an anti-IgE monoclonal antibody, effectively targets the severe allergic asthma phenotype. Pregnancy-associated plasma protein-A (PAPP-A) is an insulin-like growth factor binding protein-4 (IGFBP-4) protease, increasing local insulin-like growth factor (IGF)-1 concentrations, which in turn initiating a cascade involved in the regulation of cell growth, differentiation, and proliferation in various tissues...
December 6, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29210195/hair-nicotine-at-15-months-old-tobacco-exposure-and-wheeze-or-asthma-from-15-months-to-6-years-old
#3
Philip K Pattemore, Karen M Silvers, Chris M Frampton, Kristin Wickens, Tristram Ingham, David Fishwick, Julian Crane, G Ian Town, Michael J Epton
OBJECTIVE: To investigate the relationship between hair nicotine levels at 15 months of age and prior parent-reported smoking exposure, and the risk of wheezing and current asthma from 15 months to 6 years of age. STUDY DESIGN: We measured hair nicotine levels at 15 months of age in 376 of 535 infants enrolled in a prospective birth cohort in Christchurch, New Zealand. We obtained detailed information from parents about smoking exposure during pregnancy and in the home at 3 and 15 months of age...
December 6, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29200898/circulating-clusterin-and-osteopontin-levels-in-asthma-and-asthmatic-pregnancy
#4
Brigitta Dombai, István Ivancsó, András Bikov, Dóra Oroszi, Anikó Bohács, Veronika Müller, János Rigó, Barna Vásárhelyi, György Losonczy, Lilla Tamási
Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483-2.701] versus 2.075 [1...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29198451/development-of-the-microbiota-in-infants-and-its-role-in-maturation-of-the-gut-mucosa-and-the-immune-system
#5
Cecilia Ximenez, Javier Torres
Dysbiosis of the gut microbiota has been associated with increasing numbers of diseases, including obesity, diabetes, inflammatory bowel disease, asthma, allergy, cancer and even neurologic or behavioral disorders. The other side of the coin is that a healthy microbiota leads to a healthy human development, to a mature and well trained immune system and to an efficient metabolic machinery. What we have learned in adults is in the end the result of a good start, a programmed, healthy development of the microbiota that must occur in the early years of life, probably even starting during the fetal stage...
November 30, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29193127/pregnancy-and-perinatal-conditions-and-atopic-disease-prevalence-in-childhood-and-adulthood
#6
Jessica Gerlich, Nora Benecke, Astrid S Peters-Weist, Sabine Heinrich, Diana Roller, Jon Genuneit, Gudrun Weinmayr, Doris Windstetter, Holger Dressel, U Range, Dennis Nowak, Erika von Mutius, Katja Radon, Christian Vogelberg
BACKGROUND: Previous studies showed controversial results for the influence of pregnancy-related and perinatal factors on subsequent respiratory and atopic diseases in children. The aim of this study was to assess the association between perinatal variables and the prevalence of asthma, bronchial hyperreactivity, flexural eczema, allergic rhinitis, and sensitization in childhood and early adulthood. METHODS: The studied population was first examined in Munich and Dresden in 1995/1996 at age 9-11 yrs...
November 29, 2017: Allergy
https://www.readbyqxmd.com/read/29168282/risk-factors-for-asthma-occurrence-in-children-with-early-onset-atopic-dermatitis-an-8-year-follow-up-study
#7
Ching-Chun Huang, Tung-Liang Chiang, Pau-Chung Chen, Shio-Jean Lin, Hui-Ju Wen, Yue-Liang Guo
BACKGROUND: Children with early-onset atopic dermatitis (AD) are at substantial risk of developing asthma later in life, and identifying the critical window of detrimental exposure is advantageous for implementing preventive actions. The aim of this study was to evaluate the role of exposure to environmental modifiers during pregnancy and early childhood in asthma occurrence in an infantile AD cohort. METHODS: Eligible study participants were selected from the Taiwan Birth Cohort Study, which enrolled 24200 newborns in 2005...
November 23, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29167579/the-first-1000-days-of-life-factors-associated-with-childhood-asthma-symptoms-brisa-cohort-brazil
#8
Joelma Ximenes Prado Teixeira Nascimento, Cecilia Claudia Costa Ribeiro, Rosângela Fernandes Lucena Batista, Maria Teresa Seabra Soares de Britto Alves, Vanda Maria Ferreira Simões, Luana Lopes Padilha, Viviane Cunha Cardoso, Elcio Oliveira Vianna, Heloisa Bettiol, Marco Antonio Barbieri, Antônio Augusto Moura Da Silva
This prospective study used data from the BRISA Cohort, São Luís, Brazil (n = 1140) and analyzed associations between environmental factors up to the first 1000 days of life and "Childhood Asthma Symptoms". "Childhood Asthma Symptoms" was a latent variable based on the number of wheezing episodes, emergency care visit due to wheezing, diagnosis of asthma and diagnosis of rhinitis. A theoretical model that included prenatal factors (socioeconomic status, pregestational body mass index-BMI, soft drink and junk food consumption), birth factors (gestational age, smoking and diseases during pregnancy, birth weight and type of delivery), first year of life factors (breastfeeding, environmental aeroallergens and respiratory diseases) and BMI z-score in the second year of life, was analyzed by structural equation modeling...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29167295/sex-specific-impact-of-asthma-during-pregnancy-on-infant-gut-microbiota
#9
Petya T Koleva, Hein M Tun, Theodore Konya, David S Guttman, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Padmaja Subbarao, Malcolm R Sears, James A Scott, Anita L Kozyrskyj
Asthma during pregnancy is associated with retardation of fetal growth in a sex-specific manner. Lactobacilli microbes influence infant growth. This study aimed to determine whether lactobacilli and other microbes are reduced in the gut of infants born to an asthmatic mother, and whether this differs by the sex of the infant.Mother-infant pairs (N=1021) from the Canadian Healthy Infant Longitudinal Development full-term cohort were studied. The abundance of infant faecal microbiota at 3-4 months, profiled by gene sequencing, was compared between both women with and without asthma treatment during pregnancy...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29166819/pregnancy-outcomes-among-women-with-asthma
#10
Haitham Baghlaf, Andrea R Spence, Nicholas Czuzoj-Shulman, Haim Arie Abenhaim
PURPOSE: The purpose of this study is to examine the association between maternal asthma and pregnancy, delivery and neonatal outcomes. MATERIALS AND METHODS: We carried out a retrospective cohort study using the Health Care Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) database from 2003 to 2011. Among women who delivered during this time period, we compared pregnancy, delivery, and neonatal outcomes in asthmatics versus non-asthmatics. Multivariate logistic regression was used to estimate adjusted odds ratios and 95% confidence intervals...
November 22, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29165157/the-hokkaido-birth-cohort-study-on-environment-and-children-s-health-cohort-profile-updated-2017
#11
Reiko Kishi, Atsuko Araki, Machiko Minatoya, Tomoyuki Hanaoka, Chihiro Miyashita, Sachiko Itoh, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Ryu Miura, Naomi Tamura, Kumiko Ito, Houman Goudarzi
The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary study goals are (1) to examine the effects of low-level environmental chemical exposures on birth outcomes, including birth defects and growth retardation; (2) to follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders and perform a longitudinal observation of child development; (3) to identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) to identify the additive effects of various chemicals, including tobacco smoking...
May 18, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29159833/maternal-hypothyroidism-in-the-perinatal-period-and-childhood-asthma-in-the-offspring
#12
Xiaoqin Liu, Stine Linding Andersen, Jørn Olsen, Esben Agerbo, Vivi Schlünssen, Shyamali Chandrika Dharmage, Trine Munk-Olsen
BACKGROUND: There is increasing interest in the possible link between maternal hypothyroidism in the perinatal period and childhood asthma risk. We explored this in the present study while accounting for the timing of hypothyroidism diagnosis. Further, we evaluated whether the risk was moderated by thyroid hormone treatment during pregnancy. METHODS: We conducted a population-based cohort study using Danish national registers. All liveborn singletons in Denmark from 1998 to 2007 were identified...
November 21, 2017: Allergy
https://www.readbyqxmd.com/read/29134693/microglia-from-offspring-of-dams-with-allergic-asthma-exhibit-epigenomic-alterations-in-genes-dysregulated-in-autism
#13
Annie Vogel Ciernia, Milo Careaga, Janine M LaSalle, Paul Ashwood
Dysregulation in immune responses during pregnancy increases the risk of a having a child with an autism spectrum disorder (ASD). Asthma is one of the most common chronic diseases among pregnant women, and symptoms often worsen during pregnancy. We recently developed a mouse model of maternal allergic asthma (MAA) that induces changes in sociability, repetitive, and perseverative behaviors in the offspring. Since epigenetic changes help a static genome adapt to the maternal environment, activation of the immune system may epigenetically alter fetal microglia, the brain's resident immune cells...
November 14, 2017: Glia
https://www.readbyqxmd.com/read/29125902/asthma-in-children-of-mothers-with-systemic-lupus-erythematosus-and-the-role-of-preterm-birth
#14
Marios Rossides, Cathina Nguyen, Elizabeth V Arkema, Julia F Simard
OBJECTIVE: Systemic lupus erythematosus (SLE) and asthma share inheritable IgE-related pathophysiology, but the association between maternal SLE and asthma in the offspring has not been explored. Our aim was to investigate the association between maternal SLE during pregnancy and childhood asthma and examine the role of preterm birth as a mediator of the association using Swedish register data. METHODS: Information on 12000 singleton live births (2001-2013) was collected from the Medical Birth Register...
November 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29117460/maternal-folic-acid-use-during-pregnancy-mthfr-polymorphism-and-child-s-lung-function-and-asthma
#15
Herman T den Dekker, Vincent W V Jaddoe, Irwin K Reiss, Johan C de Jongste, Liesbeth Duijts
BACKGROUND: Folic acid supplement use during pregnancy might affect childhood respiratory health, potentially mediated by methylenetetrahydrofolate-reductase polymorphism C677T (MTHFR-C677T) carriership. OBJECTIVES: We examined the associations of maternal folic acid supplement use and folate, vitamin B12 and homocysteine concentrations during pregnancy with childhood lung function and asthma. METHODS: This study was embedded in a population-based prospective cohort study among 5,653 children...
November 8, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29108868/does-vitamin-e-prevent-asthma-or-wheeze-in-children-a-systematic-review-and-meta-analysis
#16
REVIEW
Hui Wu, Chunwei Zhang, Yongqing Wang, Yanlin Li
Asthma is a heterogeneous disease with multiple phenotypes. Epidemiologic studies suggest a close relationship between vitamin E and the occurrence of asthma, wheezing and atopic conditions during childhood. Previous results on its effects have been conflicting. The aim of this meta-analysis was to critically examine the current evidence on the association of vitamin E with childhood asthma and wheezing. We searched electronic databases for observational studies in English-language journals published from 2000 to 2016...
October 16, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29101450/diet-in-pregnancy-more-than-food
#17
REVIEW
H Danielewicz, G Myszczyszyn, A Dębińska, A Myszkal, A Boznański, L Hirnle
High food quality, together with adequate macro- and micronutrient intake in pregnancy, is crucial for the health status of the mother and child. Recent findings suggest that it could also be beneficial or harmful in the context of the well-being of the whole future population. According to the developmental origins of health and disease hypothesis, most conditions that occur in adulthood originate in foetal life. Moreover, some epigenetic events, modified inter alia by diet, impact more than one generation...
December 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29089129/effects-of-prenatal-di-2-ethylhexyl-phthalate-exposure-on-childhood-allergies-and-infectious-diseases-the-hokkaido-study-on-environment-and-children-s-health
#18
Yu Ait Bamai, Chihiro Miyashita, Atsuko Araki, Tamie Nakajima, Seiko Sasaki, Reiko Kishi
Phthalates are widely used in consumer products, and experimental studies suggest that exposure to phthalates increase the risk of allergies. However, epidemiologic evidence on the associations between prenatal phthalate exposure and allergies/infectious diseases and cord blood immunoglobulin E (IgE) levels is limited. This study aimed to evaluate the associations between maternal mono(2-ethylhexyl) phthalate (MEHP) levels and cord blood IgE levels at birth (n=127), as well as the risk of allergies/infectious diseases in participants up to 7years of age; the participants were 1...
October 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29077711/prenatal-vitamin-d-supplementation-reduces-risk-of-asthma-recurrent-wheeze-in-early-childhood-a-combined-analysis-of-two-randomized-controlled-trials
#19
Helene M Wolsk, Bo L Chawes, Augusto A Litonjua, Bruce W Hollis, Johannes Waage, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Scott T Weiss
BACKGROUND: We recently published two independent randomized controlled trials of vitamin D supplementation during pregnancy, both indicating a >20% reduced risk of asthma/recurrent wheeze in the offspring by 3 years of age. However, neither reached statistical significance. OBJECTIVE: To perform a combined analysis of the two trials and investigate whether maternal 25-hydroxy-vitamin D (25(OH)D) level at trial entry modified the intervention effect. METHODS: VDAART (N = 806) and COPSAC2010...
2017: PloS One
https://www.readbyqxmd.com/read/29070270/prenatal-maternal-depression-related-to-allergic-rhinoconjunctivitis-in-the-first-5-years-of-life-in-children-of-the-eden-mother-child-cohort-study
#20
Cailiang Zhou, Gladys Ibanez, Vincent Miramont, Magali Steinecker, Nour Baiz, Soutrik Banerjee, Jocelyne Just, Isabella Annesi-Maesano, Julie Chastang
Backgroud: Evidence about the relationship between prenatal maternal depression and the development of childhood asthma and allergies in early life is scarce. We aimed to examine this relationship by using data set of EDEN mother-child cohort study. A total of 1139 children were followed-up until the age of 5 years. METHODS: Prenatal maternal depression was self-reported by using the Centre for Epidemiological Studies-Depression scale (CES-D) questionnaire and was classified into binary variable (maternal depression [CES-D score of ≥16] and no maternal depression [CES-D score of <16])...
October 1, 2017: Allergy & Rhinology
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