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Asthma in pregnancy

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https://www.readbyqxmd.com/read/27931277/american-academy-of-allergy-asthma-immunology-membership-experience-with-allergen-immunotherapy-safety-in-patients-with-specific-medical-conditions
#1
Dsire E S Larenas-Linnemann, David W Hauswirth, Christopher W Calabria, Lawrence D Sher, Matthew A Rank
BACKGROUND: Little data in the literature exist concerning patients with certain underlying medical conditions who receive allergen subcutaneous immunotherapy (SCIT). OBJECTIVE: To survey allergists' experience with SCIT in patients with medical conditions considered to impose an elevated risk for untoward outcomes. METHODS: A Web-based survey was conducted among members of the American Academy of Allergy, Asthma Immunology to query about their experience with SCIT in patients with certain medical conditions...
September 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27927045/pharmacological-difficulties-in-the-treatment-of-asthma-in-pregnant-women
#2
Jennifer A Namazy, Michael Schatz
This is a review of the diagnosis and management of asthma in the pregnant patient. Asthma may adversely affect both maternal quality of life and, perinatal outcomes. Optimal management of asthma is thus important for both mother and baby. Areas Covered: Special attention is paid to the challenges in diagnosis and management of asthma during pregnancy. Expert Commentary: This article reviews the safety of asthma medications commonly used during pregnancy.
December 7, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27917572/mannitol-challenge-testing-for-asthma-in-a-community-cohort-of-young-adults
#3
Elisha C White, Nicholas de Klerk, Zoltan Hantos, Monique Priston, Elysia M Hollams, Alan James, Peter D Sly, Patrick G Holt, Graham L Hall
BACKGROUND AND OBJECTIVE: Mannitol challenge testing is an established tool for clinical asthma diagnosis, and can be performed outside of specialized respiratory laboratories. Despite applicability in both clinical and non-clinical populations, with different pre-test asthma probabilities, differences in diagnostic properties have not been well explored. This study aimed to quantify the diagnostic utility of mannitol challenge testing for asthma in a community cohort and a symptomatic wheezing subset of this cohort...
December 5, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27913770/cor-triatriatum-a-review
#4
REVIEW
Ajay Kumar Jha, Neeti Makhija
Cor triatriatum is a rare congenital cardiac anomaly defined by an abnormal septation within the atrium (left or right) leading to inflow obstruction to the respective ventricles. It exists either in isolated classical form or may be associated with simple to complex congenital cardiac anomalies. Several anatomical variants exist even in the classical form, and therefore, it may require multimodal diagnostic modalities to characterize and differentiate for better percutaneous interventional or surgical planning...
December 2, 2016: Seminars in Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27899314/preeclampsia-and-the-risk-of-cataract-extraction-in-life
#5
Nathalie Auger, Marc-André Rhéaume, Gilles Paradis, Jessica Healy-Profitós, Ada Hsieh, William D Fraser
BACKGROUND: Pregnancy-related risk factors for cataract are understudied, including the possibility that preeclampsia increases the risk of cataract later in life. OBJECTIVE: To evaluate the long term risk of cataract extraction following a preeclamptic pregnancy STUDY DESIGN: We carried out a historic cohort study of 1,108,541 women who delivered at least one infant in any hospital in the province of Quebec, Canada between 1989 and 2013, including 64,350 with preeclampsia and 5,732 with cataract extractions...
November 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27888986/relationship-between-birth-weight-maternal-smoking-during-pregnancy-and-childhood-and-adolescent-lung-function-a-path-analysis
#6
Pallavi Balte, Wilfried Karmaus, Graham Roberts, Ramesh Kurukulaaratchy, Frances Mitchell, Hasan Arshad
BACKGROUND: Low birth weight and gestational maternal smoking have been linked with reduced lung function in children in many cross sectional studies. However, these associations have not yet been assessed with repeated measurements of lung function. Our aim was to investigate the effects of birth weight, gestational age, and gestational maternal smoking on lung function in children at age 10 and 18 years. METHODS: In the Isle of Wight birth cohort spirometry was performed at age 10 and 18 years...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27878468/the-risk-of-adverse-pregnancy-outcome-after-first-trimester-exposure-to-h1-antihistamines-a-systematic-review-and-meta-analysis
#7
REVIEW
Fatma Etwel, Lauren H Faught, Michael J Rieder, Gideon Koren
INTRODUCTION: H1 antihistamines are used for the treatment of nausea and vomiting during pregnancy as well as the symptomatic relief of asthma, urticaria, allergy, and the common cold. Although they are overall felt to be safe during pregnancy, recently several studies have challenged this assumption, as millions of women are exposed to them in the first trimester. METHODS: Following the guidelines of PRISMA, a systematic review was performed to retrieve all published articles involving H1-antihistamine exposure during pregnancy...
November 22, 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27866770/tetanus-vaccination-is-associated-with-differential-dna-methylation-reduces-the-risk-of-asthma-in-adolescence
#8
Vimala Devi Janjanam, Nandini Mukherjee, Gabrielle A Lockett, Faisal I Rezwan, Ramesh Kurukulaaratchy, Frances Mitchell, Hongmei Zhang, Hasan Arshad, John W Holloway, Wilfried Karmaus
BACKGROUND: Vaccinations have been suggested to be associated with increased risk of allergic diseases. Tetanus vaccination is one of the most frequently administered vaccines as a part of wound management and was also found to be associated with increased serum IgE levels. We hypothesized that the vaccination modifies the risk of allergic diseases through epigenetic changes such as DNA methylation. METHOD: Data on tetanus vaccination between 10 and 18years of age was collected from a birth cohort established on the Isle of Wight UK in 1989...
December 12, 2016: Vaccine
https://www.readbyqxmd.com/read/27853176/smoke-free-legislation-and-child-health
#9
REVIEW
Timor Faber, Jasper V Been, Irwin K Reiss, Johan P Mackenbach, Aziz Sheikh
In this paper, we aim to present an overview of the scientific literature on the link between smoke-free legislation and early-life health outcomes. Exposure to second-hand smoke is responsible for an estimated 166 ,000 child deaths each year worldwide. To protect people from tobacco smoke, the World Health Organization recommends the implementation of comprehensive smoke-free legislation that prohibits smoking in all public indoor spaces, including workplaces, bars and restaurants. The implementation of such legislation has been found to reduce tobacco smoke exposure, encourage people to quit smoking and improve adult health outcomes...
November 17, 2016: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/27832763/a-comparison-of-intestinal-microbiota-in-a-population-of-low-risk-infants-exposed-and-not-exposed-to-intrapartum-antibiotics-the-baby-microbiota-of-the-intestine-cohort-study-protocol
#10
Julia Simioni, Eileen K Hutton, Elizabeth Gunn, Alison C Holloway, Jennifer C Stearns, Helen McDonald, Andrea Mousseau, Jonathan D Schertzer, Elyanne M Ratcliffe, Lehana Thabane, Michael G Surette, Katherine M Morrison
BACKGROUND: The intestinal microbiota influences metabolic, nutritional, and immunologic processes and has been associated with a broad range of adverse health outcomes including asthma, obesity and Type 2 diabetes. Early life exposures may alter the course of gut microbial colonization leading to differences in metabolic and immune regulation throughout life. Although approximately 50 % of low-risk full-term infants born in Canada are exposed to intrapartum antibiotics, little is known about the influence of this common prophylactic treatment on the developing neonatal intestinal microbiota...
November 10, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27826703/leukotriene-receptor-antagonists-and-antiallergy-drugs
#11
Tsutomu Tamada, Masakazu Ichinose
As one of the candidates of the therapeutic strategy for asthma in addition to inhaled corticosteroids (ICS), leukotriene receptor antagonists (LTRAs) are known to be useful for long-term management of asthma patients complicated by allergic rhinitis (AR) or exercise-induced asthma (EIA). Currently available LTRAs are pranlukast hydrate, zafirlukast, and montelukast. These LTRAs have a bronchodilator action and inhibit airway inflammation, resulting in a significant improvement of asthma symptoms, respiratory function, inhalation frequency of as-needed inhaled β2-agonist, airway inflammation, airway hyperresponsiveness, dosage of ICSs, asthma exacerbations, and patients' QOL...
November 9, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27826434/development-and-piloting-of-a-food-based-intervention-to-increase-vitamin-e-intake-in-pregnant-women-in-a-randomized-controlled-trial
#12
Julia Clark, Nikki Holgan, Leone Craig, Heather Morgan, Peter Danielian, Graham Devereux
Low maternal vitamin E intake during pregnancy is associated with childhood asthma and a trial is required to test whether increasing maternal vitamin E intake reduces childhood asthma. This study investigated whether such a trial is possible using food to increase vitamin E intake. Three soup varieties with enhanced vitamin E content (16-19 mg/can) from food ingredients were developed. Near identical retail versions (vitamin E 1-4 mg/can) acted as placebo. In a pilot double-blind randomized controlled trial, pregnant women were randomized 1:1 to enhanced or placebo soups (three tins/week) from 12 weeks gestation to delivery...
November 2016: Food Science & Nutrition
https://www.readbyqxmd.com/read/27817809/low-risk-of-adverse-obstetrical-and-perinatal-outcome-in-pregnancies-complicated-by-asthma-a-case-control-study
#13
Zarqa Ali, Lisbeth Nilas, Charlotte Suppli Ulrik
BACKGROUND: Asthma in pregnancy have been associated with an increased risk of pregnancy complications. Our aim was to estimate incidence and describe risk factors for adverse obstetrical and perinatal outcomes in pregnant women with asthma. METHODS: Women enrolled in the Management of Asthma during Pregnancy (MAP) program were each matched with three controls (i.e. consecutive women giving birth at our obstetrical service). Asthma severity was classified according to treatment step...
November 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27798419/novel-targets-of-omalizumab-in-asthma
#14
Caroline Sattler, Gilles Garcia, Marc Humbert
PURPOSE OF REVIEW: Omalizumab is a recombinant humanized anti-IgE monoclonal antibody approved in the US for moderate to severe persistent allergic asthma (severe persistent asthma in the European Union), uncontrolled despite treatment with inhaled corticosteroids and long-acting beta2 agonists. It reduces asthma exacerbations, symptoms, oral corticosteroid doses, and improves quality of life. RECENT FINDINGS: Omalizumab may have an antiviral effect when used as a preventive therapy for fall exacerbations in children and teenagers...
January 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27794037/pre-and-postnatal-smoking-exposure-and-risk-of-atopic-eczema-in-young-japanese-children-a-prospective-pre-birth-cohort-study
#15
Keiko Tanaka, Yoshihiro Miyake, Shinya Furukawa, Masashi Arakawa
INTRODUCTION: Epidemiological evidence regarding the effect of perinatal smoking exposure on atopic eczema in children continues to be inconclusive. The aim of this prospective prebirth cohort study was to investigate the association between prenatal smoking exposure and postnatal living with household smokers and the risk of atopic eczema in Japanese children aged 23 to 29 months. METHODS: Study subjects were 1354 Japanese mother-child pairs. Information on the variables under study was obtained through questionnaires which were completed by mothers, first prior to delivery, then shortly after birth and subsequently around 4, 12, and 24 months after delivery...
October 28, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27793178/urinary-incontinence-among-pregnant-women-following-antenatal-care-at-university-of-gondar-hospital-north-west-ethiopia
#16
Abey Bekele, Mulat Adefris, Senait Demeke
BACKGROUND: Urinary incontinence is defined as a complaint of any involuntary leakage of urine. During pregnancy, the prevalence of urinary incontinence ranges from 32 to 64 %. Different factors like demographic factors, obstetric factors, and other external factors affect urinary incontinence. In Ethiopia, there is no study conducted so far on the magnitude of urinary incontinence and factors associated among pregnant women. The objective of this study was to determine the prevalence of urinary incontinence and associated factors among pregnant women following antenatal care at the University of Gondar Hospital...
October 28, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27789184/a-limited-survey-based-uncontrolled-follow-up-study-of-children-born-after-ooplasmic-transplantation-in-a-single-centre
#17
Serena H Chen, Claudia Pascale, Maria Jackson, Mary Ann Szvetecz, Jacques Cohen
Experimental ooplasmic transplantation from donor to recipient oocyte took place between 1996 and 2001 at Saint Barnabas Medical Center, USA. Indication for 33 patients was repeated implantation failure. Thirteen couples had 17 babies. One patient delivered twins from mixed ooplasmic and donor egg embryos. A limited survey-based follow-up study on the children is reported: 12 out of 13 parents completed a questionnaire on pregnancy, birth, health, academic performance and disclosure. Parents of a quadruplet did not participate...
October 24, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27778417/pregnancy-alters-the-circulating-b-cell-compartment-in-atopic-asthmatic-women-and-transitional-b-cells-are-positively-associated-with-the-development-of-allergy-manifestations-in-their-progeny
#18
Catarina Martins, Jorge Lima, Glória Nunes, Luís Miguel Borrego
PROBLEM: Maternal atopy is a risk factor for allergy. B cells are poorly studied in reproduction and atopy. We aimed to assess how pregnancy affects B cells in atopic women and whether B cells relate to allergic manifestations in offspring. METHOD OF STUDY: Women with and without atopic asthma, pregnant and non-pregnant were enrolled for the study, and circulating B cells were evaluated by flow cytometry, using CD19, CD27, CD38, IgD, and IgM. RESULTS: Compared to healthy non-pregnant, atopic asthmatic non-pregnant (ANP) women presented increased B cell counts, enlarged memory subsets, less transitional cells, and plasmablasts...
December 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27763990/maternal-history-of-childhood-abuse-and-risk-of-asthma-and-allergy-in-2-year-old-children
#19
Lianne M Tomfohr-Madsen, Hamideh Bayrampour, Suzanne Tough
OBJECTIVES: Exposure to child abuse (CA) is associated with an increased risk of developing asthma and allergies; it is unknown if that risk is present across generations. This study investigated if 2-year-old children born to mothers with a history of CA were at an increased risk of receiving a diagnosis of asthma or allergies. METHODS: Data from 1,551 participants were collected as part of the All Our Babies (AOB) study, a prospective pregnancy cohort. During pregnancy, each woman provided information about her own history of CA, and at 24 months postpartum, she provided information about her child's medical diagnoses...
October 19, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27746239/factors-influencing-the-infant-gut-microbiome-at-age-3-6%C3%A2-months-findings-from-the-ethnically-diverse-vitamin-d-antenatal-asthma-reduction-trial-vdaart
#20
Joanne E Sordillo, Yanjiao Zhou, Michael J McGeachie, John Ziniti, Nancy Lange, Nancy Laranjo, Jessica R Savage, Vincent Carey, George O'Connor, Megan Sandel, Robert Strunk, Leonard Bacharier, Robert Zeiger, Scott T Weiss, George Weinstock, Diane R Gold, Augusto A Litonjua
BACKGROUND: The gut microbiome in infancy influences immune system maturation, and may have an important impact on allergic disease risk. OBJECTIVE: We sought to determine how prenatal and early life factors impact the gut microbiome in a relatively large, ethnically diverse study population of infants at age 3 to 6 months, who were enrolled in Vitamin D Antenatal Asthma Reduction Trial, a clinical trial of vitamin D supplementation in pregnancy to prevent asthma and allergies in offspring...
October 13, 2016: Journal of Allergy and Clinical Immunology
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