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https://www.readbyqxmd.com/read/28231371/efficacy-of-intralipid-infusion-in-reducing-amphotericin-b-associated-nephrotoxicity-in-head-and-neck-invasive-fungal-infection-a-randomized-controlled-trial
#1
Mehrdad Hasibi, Sirous Jafari, Seyyed Ali Manshadi, Marjan Asadollahi, Mohammadreza Salehi, Varasteh Vakili Zarch, Ali Kouhi
Amphotericin B deoxycholate (ABD) is the best therapeutic agent available for the treatment of most systemic fungal infections. However, some untoward adverse effects such as nephrotoxicity may limit its appropriate therapeutic use. We conducted a randomized, controlled trial ofthe infusion of fat emulsion (Intralipid) shortly after the infusion of ABD to evaluate its effects on reducing ABD-associated nephrotoxicity. Our patient population was made up of 31 patients who were randomized into two groups: an intervention group (n = 16) and a control group (15 patients)...
February 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28223143/comparison-of-photoinactivation-of-t-rubrum-by-new-methylene-blue-nmb-and-indocyanine-green-emundo-%C3%A2
#2
Reza Fekrazad, Arash Poorsattar Bejeh Mir, Mina Kahyaie Aghdam, Vadood Ghasemi Barghi
BACKGROUND: Superficial mycotic skin infections which are predominantly caused by Trichophyton rubrum, poorly responses to conventional therapies. A great amount of attention has focused on to find more effective treatments. The current work is aimed to compare the effectiveness of phoinactivation of Trichophyton rubrum by two relatively new photosensitizers: a phenothiazinium dye(New methylene blue) and Indocyanine green (EmunDo(®)). MATERIALS AND METHODS: A Final inoculum of T...
February 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28220533/does-dextrose-gel-prevent-treatment-failure-in-infants-with-neonatal-hypoglycaemia
#3
Stephanie L Bourque, Paul J Rozance
No abstract text is available yet for this article.
February 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28218386/glucose-adsorption-to-chitosan-membranes-increases-proliferation-of-human-chondrocyte-via-mammalian-target-of-rapamycin-complex-1-and-sterol-regulatory-element-binding-protein-1-signaling
#4
Shun-Fu Chang, Kuo-Chin Huang, Chin-Chang Cheng, Yu-Ping Su, Ko-Chao Lee, Cheng-Nan Chen, Hsin-I Chang
BACKGROUND: Osteoarthritis (OA) is currently still an irreversible degenerative disease of the articular cartilage. Recent, dextrose (D-glucose) intraarticular injection prolotherapy for OA patients has been reported to benefit the chondrogenic stimulation of damaged cartilage. However, the detailed mechanism of glucose's effect on cartilage repair remains unclear. Chitosan, a naturally derived polysaccharide, has recently been investigated as a surgical or dental dressing to control breeding...
February 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28215890/effect-of-oral-calcium-administration-on-the-cure-and-reproductive-performance-of-holstein-cows-diagnosed-with-puerperal-metritis
#5
Pablo Pinedo, Juan Velez, Gilberto Solano, Nelson Rodriguez, Julianne Naves, Gustavo M Schuenemann, Carlos Risco
Our objective was to evaluate the effect of oral calcium administration on clinical cure, survival, subsequent presentation of peripartal health disorders, and reproductive performance of Holstein cows diagnosed with puerperal metritis (PM) under certified organic management. A second objective was to evaluate the metabolic status at calving and at the time of PM diagnosis (d 0) in affected and matched healthy cows. Cows diagnosed with PM (n = 200) were assigned randomly to receive 1 of 2 treatments: (1) control received 3...
February 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28215611/effectiveness-of-prolotherapy-in-the-treatment-of-chronic-rotator-cuff-lesions
#6
Mehmet Murat Seven, Omer Ersen, Serkan Akpancar, Huseyin Ozkan, Selim Turkkan, Yavuz Yıldız, Kenan Koca
BACKGROUND: Rotator cuff lesions are one of the major causes of shoulder pain and dysfunction. Numerous non-surgical treatment modalities have been described for chronic rotator cuff lesions, but the debate continues over the optimal procedure. The aim of this report is to present the results of prolotherapy in the treatment of chronic refractory rotator cuff lesions. HYPOTHESIS: Dextrose prolotherapy will reduce pain and improve shoulder function and patient satisfaction...
February 16, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28215169/bioactive-constituents-from-an-endophytic-fungus-penicillium-polonicum-nfw9-associated-with-taxus-fauna
#7
Nighat Fatima, Tawanun Sripisut, Ui Joung Youn, Safia Ahmed, Ihsan Ul-Haq, Ulyana Muñoz-Acuña, Charles J Simmons, Muneer Ahmed Qazi, Muniba Jadoon, Ghee Teng Tan, Esperanza J Carcache de Blanco, Leng Chee Chang
BACKGROUND: Endophytic fungi are being recognized as vital and untapped sources of a variety of structurally novel and unique bioactive secondary metabolites in the field of natural products drug discovery. Herein, this study reports the isolation and characterization of secondary metabolites from an endophytic fungus Penicillium polonicum (NFW9) associated with Taxus fuana. METHODS: Extracts of the endophytic fungus cultured on potato dextrose agar were purified using several chromatographic techniques...
February 16, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28205208/skin-to-skin-care-for-procedural-pain-in-neonates
#8
REVIEW
Celeste Johnston, Marsha Campbell-Yeo, Timothy Disher, Britney Benoit, Ananda Fernandes, David Streiner, Darlene Inglis, Rebekah Zee
BACKGROUND: Skin-to-skin care (SSC), often referred to as 'kangaroo care' (KC) due to its similarity with marsupial behaviour of ventral maternal-infant contact, is one non-pharmacological intervention for pain control in infants. OBJECTIVES: The primary objectives were to determine the effect of SSC alone on pain from medical or nursing procedures in neonates compared to no intervention, sucrose or other analgesics, or additions to simple SSC such as rocking; and to determine the effects of the amount of SSC (duration in minutes), method of administration (e...
February 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28205121/effect-of-n-acetylcysteine-on-mortality-and-liver-transplantation-rate-in-non-acetaminophen-induced-acute-liver-failure-a-multicenter-study
#9
Samar K Darweesh, Mona F Ibrahim, Mahmoud A El-Tahawy
INTRODUCTION AND AIM: Previous studies and systematic reviews have not provided conclusive evidence on the effect of N-acetylcysteine (NAC) in non-acetaminophen-induced acute liver failure (NAI-ALF). We aimed to study the value of intravenous NAC in reducing liver transplantation and mortality in NAI-ALF. PATIENTS AND METHODS: In a prospective, multicenter, observational study, acute liver failure patients without clinical or historical evidence of acetaminophen overdose were enrolled...
February 15, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28204952/a-preliminary-report-of-indigenous-fungal-isolates-from-contaminated-municipal-solid-waste-site-in-india
#10
Abhishek Kumar Awasthi, Akhilesh Kumar Pandey, Jamaluddin Khan
Municipal solid waste (MSW) containing harmful substances is a major concern in waste management and can cause adverse effects on diversity of fungi in soil. The main objective was to evaluate the fungal diversity inhabiting in the soil nearby MSW disposal site. The fungal strains were isolated in potato dextrose agar (PDA), media at temperatures 28 ± 1 °C by using standard serial dilution pour plate method, and appeared fungal colonies identified based on morphological characteristics. The overall most fungal diversity was found in soil sample collected from S5, followed by S4, S3, S1, and least in S2 site...
February 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28188331/urnula-sp-an-endophyte-of-dicksonia-antarctica-making-a-fragrant-mixture-of-biologically-active-volatile-organic-compounds
#11
Gary Strobel, Amy Ericksen, Joe Sears, Jie Xie, Brad Geary, Bryan Blatt
Urnula sp. was isolated as an endophyte of Dicksonia antarctica and identified primarily on the basis of its ITS sequence and morphological features. The anamorphic state of the fungus appeared as a hyphomyceteous-like fungus as based on its features in culture and scanning electron microscopy examination of its spores. On potato dextrose agar (PDA), the organism makes a characteristic fragrance resembling peach pie with vanilla overtones. A GC/MS analysis done on the volatile organic compounds (VOCs) of this organism, trapped by carbotrap methodology, revealed over 150 compounds with high MS matching quality being noted for 44 of these...
February 10, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28185458/mutant-potential-ubiquitination-sites-in-dur3p-enhance-the-urea-and-ethyl-carbamate-reduction-in-a-model-rice-wine-system
#12
Peng Zhang, Guocheng Du, Huijun Zou, Guangfa Xie, Jian Chen, Zhongping Shi, Jingwen Zhou
Ubiquitination can significantly affect the endocytosis and degradation of plasma membrane proteins. Here, the ubiquitination of a Saccharomyces cerevisiae urea plasma membrane transporter (Dur3p) was altered. Two potential ubiquitination sites, lysine residues K556 and K571, of Dur3p were predicted and replaced by arginine, and the effects of these mutations on urea utilization and formation under different nitrogen conditions were investigated. Compared with Dur3p, the Dur3pK556R mutant showed a 20.1% decrease in ubiquitination level in yeast nitrogen base medium containing urea and glutamine...
February 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28182028/preparation-of-arjun%C3%A4-ri%C3%A1-%C3%A1-a-using-microbes-isolated-from-woodfordia-fruticosa-flowers-dhayati
#13
Dheeraj S Randive, Sadik F Sayyad, Somnath Devidas Bhinge, Mangesh A Bhutkar
OBJECTIVE: To verify the utility of isolated fermentative microbes from Woodfordia fruticosa flowers for preparation of Arjunāriṣṭa formulation and its comparative evaluation with the same formulation prepared by traditional method. METHODOLOGY: In the present technique, isolated colonies of microorganisms from Woodfordia fruticosa (Dhātakī) flowers on Saubroad dextrose media were separated and suspended in sterile water. This suspension was aseptically added in previously sterilized mixtures containing all intended ingredients for Arjunāriṣṭa which was thereafter incubated for 20 days at 37°C to achieve optimal fermentation...
July 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28181429/fluconazole-containing-agar-sabouraud-dextrose-plates-are-not-useful-when-screening-for-susceptibility-in-candida-albicans
#14
M A Bordallo-Cardona, L J Marcos-Zambrano, E Gómez G de la Pedrosa, P Escribano, E Bouza, J Guinea, R Cantón
OBJECTIVE: Fluconazole is an alternative for candidemic patients who are not critically ill. Fluconazole is mainly fungistatic and does not completely inhibit visual Candida albicans growth. We studied the usefulness of fluconazole-containing Sabouraud dextrose agar plates for detecting susceptibility to fluconazole in C. albicans. METHODS: Adjusted inocula of 19 isolates were transferred directly onto fluconazole-containing Sabouraud dextrose plates (concentrations ranging from 0...
February 9, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28176608/validation-of-commercial-elisas-for-quantifying-anabolic-growth-factors-and-cytokines-in-canine-acd-a-anticoagulated-plasma
#15
Kate Birdwhistell, Robert Basinger, Brian Hayes, Natalie Norton, David J Hurley, Samuel P Franklin
Platelet-rich plasma has been studied extensively in dogs, but validation of enzyme-linked immunosorbent assays (ELISAs) for quantifying anabolic growth factors and inflammatory cytokines in canine plasma prepared with citrate-based anticoagulants is not available. We performed a validation of commercial ELISAs for transforming growth factor-beta 1 (TGF-β1), platelet-derived growth factor-BB (PDGF-BB), vascular endothelial growth factor (VEGF), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β) for use with canine plasma prepared with acid-citrate-dextrose, solution A (ACD-A)...
January 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28168624/antimicrobial-activity-of-endophytic-fungi-from-olive-tree-leaves
#16
Cynthia Malhadas, Ricardo Malheiro, José Alberto Pereira, Paula Guedes de Pinho, Paula Baptista
In this study, the antimicrobial potential of three fungal endophytes from leaves of Olea europaea L. was evaluated and the host plant extract effect in the antimicrobial activity was examined. The volatile compounds produced by endophytes were identified by GC/MS and further correlated with the antimicrobial activity. In potato dextrose agar, both Penicillium commune and Penicillium canescens were the most effective inhibiting Gram-positive and -negative bacteria (up to 2.7-fold compared to 30 µg/mL chloramphenicol), whereas Alternaria alternata was most effective inhibiting yeasts (up to 8...
March 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28168311/impact-of-laparotomy-and-intraperitoneal-hyperthermic-instillation-lihi-on-the-oxaliplatin-pharmacokinetics-after-intravenous-administration-in-wistar-rats
#17
María Isabel Mas-Fuster, Amelia Ramon-Lopez, Javier Lacueva, Antonio Compañ, Patricio Más-Serrano, Ricardo Nalda-Molina
PURPOSE: In peritoneal metastasis condition, the fact that most of the disease is limited to the peritoneal cavity laid the foundations for a surgical treatment, including intraperitoneal hyperthermic chemotherapy (HIPEC). The aim of this study was to evaluate the impact of the surgical procedures implied in open HIPEC technique, referred to laparotomy procedures followed by an intraperitoneal hyperthermic instillation (LIHI) on oxaliplatin tissue distribution and elimination. To delimit the influence of this procedure alone, oxaliplatin was administered as an intravenous (iv) bolus in both groups...
February 6, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28168044/anti-inflammatory-and-antioxidative-stress-effects-of-oryzanol-in-glaucomatous-rabbits
#18
Shital S Panchal, Rajesh K Patidar, Abhishek B Jha, Ahmed A Allam, Jamaan Ajarem, Shital B Butani
Purpose. γ-Oryzanol works by anti-inflammatory and radical scavenging activity as a neuroprotective, anticancer, antiulcer, and immunosuppressive agent. The present study was conducted to investigate effect of oryzanol in acute and chronic experimental glaucoma in rabbits. Methods. Effect of oryzanol was evaluated in 5% dextrose induced acute model of ocular hypertension in rabbit eye. Chronic model of glaucoma was induced with subconjunctival injection of 5% of 0.3 ml phenol. Treatment with oryzanol was given for next two weeks after induction of glaucoma...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28167893/morphogenetic-alterations-of-alternaria-alternata-exposed-to-dicarboximide-fungicide-iprodione
#19
Eunji Kim, Hye Min Lee, Young Ho Kim
Fungicide-resistant Alternaria alternata impede the practical control of the Alternaria diseases in crop fields. This study aimed to investigate cytological fungicide resistance mechanisms of A. alternata against dicarboximide fungicide iprodione. A. alternata isolated from cactus brown spot was cultured on potato-dextrose agar (PDA) with or without iprodione, and the fungal cultures with different growth characteristics from no, initial and full growth were observed by light and electron microscopy. Mycelia began to grow from one day after incubation (DAI) and continued to be in full growth (control-growth, Con-G) on PDA without fungicide, while on PDA with iprodione, no fungal growth (iprodione-no growth, Ipr-N) occurred for the first 3 DAI, but once the initial growth (iprodione-initial growth, Ipr-I) began at 4-5 DAI, the colonies grew and expanded continuously to be in full growth (iprodione-growth, Ipr-G), suggesting Ipr-I may be a turning moment of the morphogenetic changes resisting fungicidal toxicity...
February 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28164647/ethylenediaminetetraacetic-acid-sodium-citrate-heparin-and-citrate-phosphate-dextrose-adenine-anticoagulants-differentially-affect-cytokine-mrna-expression-in-blood-leukocytes
#20
Eva Herzogova, Pavlina Dankova
BACKGROUND: The aim of this study is to determine whether and how the anticoagulant agents EDTA, sodium citrate, and heparin present in vacutainers and CPDA located in transfusion bags modify peripheral blood cell behavior. METHODS: We compared the effect of four anticoagulants within an expression study quantifying mRNA by realtime PCR in 60 blood samples. RESULTS: We observed a significant increase of TNFα and CCL2 mRNA expression in leukocytes placed in EDTA anticoagulant compared to leukocytes collected with citrate or heparin (p ≤ 0...
July 1, 2016: Clinical Laboratory
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