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https://www.readbyqxmd.com/read/29230949/glucocorticoid-receptor-activation-is-associated-with-increased-resistance-to-heat-induced-hyperthermia-and-injury
#1
Yifan Chen, Tianzheng Yu
AIM: Anti-inflammatory mediators likely play a key role in maintaining thermal homeostasis and providing protection against heat stress. The aim of this study was to investigate the association between activation of the glucocorticoid receptor (GR) and resistance to heat-induced hyperthermia and injury. METHODS: Effects of heat exposure on core body temperature, muscle GR phosphorylation status and subcellular expression were examined in control mice and thermal acclimation (TA)-exposed mice...
December 12, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29229138/abdominal-wall-reconstruction-after-cytoreduction-surgery-hyperthermic-intraperitoneal-chemotherapy
#2
Anthony J Scholer, Joseph B Oliver, Jesus Rosado, Jimmy S Patel, Lindsay J Lynch, Kevin M Spiegler, Karen Houck, Ravi J Chokshi
BACKGROUND: Cytoreduction surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) improve survival and decrease recurrence of peritoneal metastasis in a select population of patients. Abdominal wall resection is often needed to achieve complete CRS and the extent of abdominal wall resection may necessitate abdominal wall reconstruction (AWR). We sought to investigate if postoperative morbidity and mortality was increased in patients who underwent AWR with CRS-HIPEC (AWR group) compared to CRS-HIPEC without AWR (non-AWR group) and to identify if patient, tumor, and operative risk factors were associated with poor outcomes following AWR...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228720/gastric-myoelectric-activity-during-cisplatin-induced-acute-and-delayed-emesis-reveals-a-temporal-impairment-of-slow-waves-in-ferrets-effects-not-reversed-by-the-glp-1-receptor-antagonist-exendin-9-39
#3
Zengbing Lu, Man P Ngan, Ge Lin, David T W Yew, Xiaodan Fan, Paul L R Andrews, John A Rudd
Preclinical studies show that the glucagon-like peptide-1 (GLP-1) receptor antagonist, exendin (9-39), can reduce acute emesis induced by cisplatin. In the present study, we investigate the effect of exendin (9-39) (100 nmol/24 h, i.c.v), on cisplatin (5 mg/kg, i.p.)-induced acute and delayed emesis and changes indicative of 'nausea' in ferrets. Cisplatin induced 37.2 ± 2.3 and 59.0 ± 7.7 retches + vomits during the 0-24 (acute) and 24-72 h (delayed) periods, respectively. Cisplatin also increased (P<0...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29214450/effects-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-hipec-in-the-treatment-of-goblet-cell-carcinoma-a-prospective-cohort-study
#4
Anders Husted Madsen, Morten Ladekarl, Gerda Elisabeth Villadsen, Henning Grønbæk, Mette Møller Sørensen, Katrine Stribolt, Vic Jilbert Verwaal, Lene Hjerrild Iversen
BACKGROUND: Goblet cell carcinoma (GCC) of the appendix is a rare disease. Treatment options vary according to disease staging. Cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) may improve survival in patients with peritoneal spreading. OBJECTIVE: The aim of this study was to examine the prognosis of patients with appendiceal GCC treated per protocol, and to evaluate the results of CRS+HIPEC in cases of peritoneal spreading...
December 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29209518/diagnosis-and-treatment-of-soft-tissue-sarcomas-of-the-extremities-and-trunk
#5
Maria Anna Smolle, Dimosthenis Andreou, Per-Ulf Tunn, Joanna Szkandera, Bernadette Liegl-Atzwanger, Andreas Leithner
The relatively low incidence and often atypical clinical presentation of soft-tissue sarcomas (STS) impedes early and adequate diagnosis. Patients may report on recently enlarged soft-tissue swellings, infrequently complain of painful lesions, or even have no symptoms at all.A thorough diagnostic work-up is essential in order to distinguish between benign soft-tissue tumours and STSs. Patient history, clinical features and radiological findings all help in assessing the underlying pathology. 'Worrying' features such as recent increase in size, deep location relative to the fascia, a tumour exceeding 4 cm in size, and invasive growth patterns seen on imaging should prompt verification by biopsy...
October 2017: EFORT Open Reviews
https://www.readbyqxmd.com/read/29204776/implications-of-hyperthermic-intraperitoneal-chemotherapy-perfusion-related-hyperglycemia
#6
Camille L Stewart, Ana Gleisner, Alison Halpern, Irada Ibrahim-Zada, Rodrigo Asturias Luna, Nathan Pearlman, Csaba Gajdos, Barish Edil, Martin McCarter
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) administration can be associated with hyperglycemia during perfusion. Little is known about this effect, and no previous studies have examined patient characteristics associated with perfusion-related hyperglycemia. METHODS: We retrospectively identified consecutive patients at a single institution treated with HIPEC from 8/2003 to 10/2016 who had intraoperative blood glucose measured. Hypertonic 1.5% dextrose-containing peritoneal dialysate was used as carrier solution in all patients...
December 4, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29204126/pharmacokinetic-ambulatory-and-hyperthermic-effects-of-3-4-methylenedioxy-n-methylcathinone-methylone-in-rats
#7
Kristýna Štefková, Monika Židková, Rachel R Horsley, Nikola Pinterová, Klára Šíchová, Libor Uttl, Marie Balíková, Hynek Danda, Martin Kuchař, Tomáš Páleníček
Methylone (3,4-methylenedioxy-N-methylcathinone) is a synthetic cathinone analog of the recreational drug ecstasy. Although it is marketed to recreational users as relatively safe, fatalities due to hyperthermia, serotonin syndrome, and multi-organ system failure have been reported. Since psychopharmacological data remain scarce, we have focused our research on pharmacokinetics, and on a detailed evaluation of temporal effects of methylone and its metabolite nor-methylone on behavior and body temperature in rats...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29204054/nuclear-heat-shock-protein-110-expression-is-associated-with-poor-prognosis-and-hyperthermo-chemotherapy-resistance-in-gastric-cancer-patients-with-peritoneal-metastasis
#8
Akiharu Kimura, Kyoichi Ogata, Bolag Altan, Takehiko Yokobori, Erito Mochiki, Mitsuhiro Yanai, Norimichi Kogure, Toru Yanoma, Masaki Suzuki, Tuya Bai, Hiroyuki Kuwano
AIM: To investigate the significance of heat shock protein 110 (HSP110) in gastric cancer (GC) patients with peritoneal metastasis undergoing hyperthermo-chemotherapy. METHODS: Primary GC patients (n = 14) with peritoneal metastasis or positive peritoneal lavage cytology who underwent distal or total gastrectomy between April 2000 and December 2011 were enrolled in this study. The patients underwent postoperative intraperitoneal hyperthermo-chemotherapy using a Thermotron RF-8 heating device two weeks after surgery...
November 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29203986/crs-and-hipec-for-pmp-use-of-the-lc-cusum-to-determine-the-number-of-procedures-required-to-attain-a-minimal-level-of-proficiency-in-delivering-the-combined-modality-treatment
#9
Aditi Bhatt, Antony George, Sanket Mehta
The learning curve for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei (PMP) which peaks at 90 procedures for the surgeon may take several years to reach. The cumulative summation (CUSUM) test of the learning curve (LC-CUSUM) was used to assess the safety of the procedure (minimal level of proficiency for the surgeon) in terms of morbidity, mortality, and completeness of cytoreduction and early oncological failure before the peak of the learning curve had been reached...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203984/ovarian-metastases-of-colorectal-origin-treatment-patterns-and-factors-affecting-outcomes
#10
Praveen S Kammar, Reena Engineer, Prachi S Patil, Vikas Ostwal, T S Shylasree, Avanish P Saklani
The purpose of this study is to evaluate the patterns of treatment and factors affecting outcomes in ovarian metastases of colorectal origins treated at our institution and to assess the response of ovarian metastases to chemotherapy. Survival in R0 and R+ resections and patients receiving only chemotherapy is also analyzed. This is a retrospective study of 25 patients registered between January 2012 and December 2015. Patient's age, disease status, mode of presentation, disease spread, mode of treatment, response to chemotherapy, completeness of resection, histology, and outcomes were considered as variables for analysis...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29200845/solid-lipid-nanoparticles-for-thermoresponsive-targeting-evidence-from-spectrophotometry-electrochemical-and-cytotoxicity-studies
#11
Mubashar Rehman, Ayesha Ihsan, Asadullah Madni, Sadia Zafar Bajwa, Di Shi, Thomas J Webster, Waheed S Khan
Thermoresponsive drug delivery systems are designed for the controlled and targeted release of therapeutic payload. These systems exploit hyperthermic temperatures (>39°C), which may be applied by some external means or due to an encountered symptom in inflammatory diseases such as cancer and arthritis. The objective of this paper was to provide some solid evidence in support of the hypothesis that solid lipid nanoparticles (SLNs) can be used for thermoresponsive targeting by undergoing solid-liquid phase transition at their melting point (MP)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29196444/temporal-analysis-of-hippocampal-ca3-gene-co-expression-networks-in-a-rat-model-of-febrile-seizures
#12
Hatylas Azevedo, Nathália Amato Khaled, Paula Santos, Fernanda Bernardi Bertonha, Carlos Alberto Moreira-Filho
Complex febrile seizures during infancy constitute an important risk factor for epilepsy development. However, little is known about the alterations induced by febrile seizures that may turn the brain susceptible to epileptic activity. In this context, the use of animal models of hyperthermic seizures (HS) could allow the temporal analysis of brain molecular changes that arise after febrile seizures. Here, we investigated temporal changes in hippocampal gene co-expression networks during the development of rats submitted to HS...
November 30, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29193085/elevated-brain-natriuretic-peptide-bnp-is-an-early-marker-for-patients-at-risk-for-complications-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-crs%C3%A2-%C3%A2-hipec
#13
Sarah B Fisher, Safia Rafeeq, Ken Hess, Travis E Grotz, Paul Mansfield, Richard Royal, Brian Badgwell, Jason Fleming, Keith Fournier, Gary N Mann
BACKGROUND: Elevated BNP is associated with adverse cardiac outcomes after noncardiac surgery. We assessed BNP values as markers of perioperative fluid status and their correlation with major/cardiopulmonary (CP) complications following CRS + HIPEC. METHODS: Fluid balance, BNP levels, and morbidity data were collected for all patients undergoing CRS + HIPEC between 6/2014 and 2/2016. RESULTS: One hundred and twenty-nine patients underwent CRS + HIPEC for appendiceal adenocarcinoma (n = 99), mesothelioma (n = 16), and colon cancer (n = 14)...
November 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29192372/prediction-of-resectability-in-pseudomyxoma-peritonei-with-a-new-ct-score
#14
Morgane Bouquot, Anthony Dohan, Etienne Gayat, Maxime Barat, Olivier Glehen, Marc Pocard, Pascal Rousset, Clarisse Eveno
BACKGROUND: Curative treatment of pseudomyxoma peritonei (PMP) is complete cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). OBJECTIVE: The aim of this study was to build and evaluate a preoperative imaging score to predict resectability. PATIENTS AND METHODS: Between 2007 and 2014, all PMP patients in two tertiary reference centers who underwent laparotomy with intent to undergo CRS and HIPEC were included in this study retrospectively...
November 30, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29191688/diaphragm-and-lung-preserving-surgery-with-hyperthermic-chemotherapy-for-malignant-pleural-mesothelioma-a-10-year-experience
#15
Marcello Carlo Ambrogi, Pietro Bertoglio, Vittorio Aprile, Antonio Chella, Stylianos Korasidis, Gabriella Fontanini, Olivia Fanucchi, Marco Lucchi, Alfredo Mussi
BACKGROUND: The best surgical treatment for malignant pleural mesothelioma is still under a debate, but recent evidence points toward a less-invasive approach to reduce morbidity and mortality. We reported our 10-year experience of a limited surgical approach associated with hyperthermic intrathoracic chemotherapy (HITHOC). MATERIAL AND METHODS: Between 2005 and 2014, patients with epithelioid or biphasic malignant pleural mesothelioma were treated with lung-diaphragm-pericardium-sparing pleurectomy associated with double-drug HITHOC; at least 3 cycles of adjuvant chemotherapy were then administered...
November 1, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29188026/is-temperature-an-important-variable-in-recovery-after-mild-traumatic-brain-injury
#16
REVIEW
Coleen M Atkins, Helen M Bramlett, W Dalton Dietrich
With nearly 42 million mild traumatic brain injuries (mTBIs) occurring worldwide every year, understanding the factors that may adversely influence recovery after mTBI is important for developing guidelines in mTBI management. Extensive clinical evidence exists documenting the detrimental effects of elevated temperature levels on recovery after moderate to severe TBI. However, whether elevated temperature alters recovery after mTBI or concussion is an active area of investigation. Individuals engaged in exercise and competitive sports regularly experience body and brain temperature increases to hyperthermic levels and these temperature increases are prolonged in hot and humid ambient environments...
2017: F1000Research
https://www.readbyqxmd.com/read/29185227/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-the-management-of-pseudomyxoma-peritonei-a-single-center-experience
#17
Ayman Zaki Azzam, Zyad Adil Alyahya, Ahmed Abbas Al Wusaibie, Tarek Mahmoud Amin
BACKGROUND AND AIMS: Pseudomyxoma peritonei (PMP) results from perforated appendiceal tumors. It is usually diagnosed preoperatively by imaging. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), although aggressive long procedure with high complications rate, was considered the optimal treatment. This study is aiming to study the role of CRS and HIPEC in the management of PMP and assess the outcome. METHODS: This is a retrospective study which was conducted at King Faisal Hospital and Research Center, a tertiary care hospital during the period from November 2008 to June 2016...
November 29, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29184697/clinical-presentation-diagnosis-classification-and-management-of-peritoneal-mesothelioma-a-review
#18
REVIEW
Alfonso García-Fadrique, Akash Mehta, Faheez Mohamed, Sanjeev Dayal, Tom Cecil, Brendan J Moran
Peritoneal mesothelioma (PM) is an uncommon but a serious, and often, fatal primary peritoneal tumour, with increasing incidence worldwide. Conventional systemic chemotherapy, generally based on experience with pleural mesothelioma, usually has disappointing results considering PM as a terminal condition. Patients usually present with non-specific symptoms of abdominal distension and pain making the diagnosis challenging. As PM is confined to the abdomen for all, or much, of its clinical course, a multimodality treatment combining cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a new standard of care, and has been reported to achieve promising survival outcomes and local disease control in selected patients with PM...
October 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29183538/laparoscopic-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-carcinomatosisfrom-gastric-cancer-its-beneficial-effects-on-reduction-and-exact-evaluation-of-the-peritoneal-cancer-index
#19
Kazuyoshi Takeshita, Yang Liu, Haruaki Ishibashi, Yutaka Yonemura
We assessed whether the laparoscopic hyperthermic intraperitoneal chemotherapy (L-HIPEC) + neoadjuvant intraperitoneal and systemic chemotherapy (NIPS) could reduce the peritoneal cancer index (PCI; which is defined by Sugerbaker) and improve the possibility to obtain a complete cytoreductive surgery (CRS with peritonectomy; basically according to the Sugerbaker's procedure). After L-HIPEC + NIPS, the PCI score was decreased in 89.5 per cent of patients, and the average score was significantly reduced. The average PCI reduction of improved PCI cases was 10...
November 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29181652/repeat-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy-for-recurrent-peritoneal-carcinomatosis-of-appendiceal-origin
#20
Toshiyuki Kitai, Kenya Yamanaka
BACKGROUND: The purpose of this study was to clarify the role of repeat cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) in the management of recurrent peritoneal carcinomatosis of appendiceal origin. METHODS: Data were retrieved on 42 patients who underwent CRS + HIPEC; 29 repeat surgical procedures were performed in 13 patients. RESULTS: Complete cytoreduction was achieved in 12 of 13 patients by the second CRS...
November 27, 2017: International Journal of Clinical Oncology
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