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https://www.readbyqxmd.com/read/29675023/increased-plasma-levels-of-danger-associated-molecular-patterns-are-associated-with-immune-suppression-and-postoperative-infections-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#1
Guus P Leijte, Hettie Custers, Jelle Gerretsen, Amon Heijne, Johannes Roth, Thomas Vogl, Gert J Scheffer, Peter Pickkers, Matthijs Kox
Introduction: Danger-associated molecular patterns (DAMPs) can elicit immune responses and may subsequently induce an immune-suppressed state. Previous work showed that increased plasma levels of DAMPs are associated with immune suppression and increased susceptibility toward infections in trauma patients. Like trauma, major surgical procedures, such as cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC), are also thought to cause profound DAMP release...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29672605/concentration-related-metabolic-rate-and-behavioral-thermoregulatory-adaptations-to-serial-administrations-of-nitrous-oxide-in-rats
#2
Karl J Kaiyala, Douglas S Ramsay
BACKGROUND: Initial administration of ≥60% nitrous oxide (N2O) to rats evokes hypothermia, but after repeated administrations the gas instead evokes hyperthermia. This sign reversal is driven mainly by increased heat production. To determine whether rats will behaviorally oppose or assist the development of hyperthermia, we previously performed thermal gradient testing. Inhalation of N2O at ≥60% causes rats to select cooler ambient temperatures both during initial administrations and during subsequent administrations in which the hyperthermic state exists...
2018: PloS One
https://www.readbyqxmd.com/read/29671139/treatment-of-isolated-peritoneal-recurrences-in-patients-with-colorectal-peritoneal-metastases-previously-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#3
Wijntje J van Eden, Fortuné M K Elekonawo, Bas J Starremans, Niels F M Kok, André J A Bremers, Johannes H W de Wilt, Arend G J Aalbers
BACKGROUND: Colorectal peritoneal carcinomatosis (PC) is preferably treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Peritoneal recurrence of disease after treatment can occur without distant metastases, with a variety of treatment options. OBJECTIVE: This study aimed to evaluate the management of isolated peritoneal recurrence after primary CRS-HIPEC. METHODS: In two tertiary referral centers, all patients who underwent CRS-HIPEC for colorectal PC between 2004 and 2015 and who developed isolated peritoneal recurrences were retrospectively evaluated...
April 18, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29667123/peritoneal-carcinomatosis-arising-from-rectal-or-colonic-adenocarcinoma-treated-with-cytoreductive-surgery-crs-hyperthermic-intraperitoneal-chemotherapy-hipec-two-different-diseases
#4
M Tonello, G Ortega-Perez, O Alonso-Casado, P Torres-Mesa, G Guiñez, S Gonzalez-Moreno
PURPOSE: Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) has poor survival. Multi-modal treatment including systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC) can be used in selected patients with curative intent. The majority published works consider PC of CRC origin as a homogenous disease. Aim of this study is to stress the different biological behaviors and survival of PC according to colonic or rectal origin. METHODS: Data of CRS and HIPEC procedures for PC of CRC origin performed at MD Anderson Cancer Center-Madrid (Spain) have been collected, dividing patients into two groups according to colonic or rectal PC...
April 17, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29652048/-should-a-doctor-take-into-consideration-the-influence-of-climatic-factors-deliberations-on-the-occasion-of-the-publication-of-a-new-monograph-the-book-of-essays-of-arid-medicine-by-z-r-zununov-i-h-nurov-and-s-z-zununova
#5
E L Povazhnaya
The authors analyze the monograph of the Uzbek scientists professor Z.R. Zununov, I.H. Nurov, and S.Z. Zununova «Essays of arid medicine» (Tashkent: «KAMALAK-PRESS» publishing house, 2016;540). The book presents the results of the comprehensive bioclimatic assessment of the arid zones of Uzbekistan, their extreme climatic conditions (such as high intensity and solar radiation and the considerable duration of its period, dry air and summer heat, sandstorms (the so-called «Afghans»), and the great variety of the natural health-improving factors including mineral waters, microclimate of the speleotherapeutic cave, the desert dune sand, etc...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29651532/32nd-annual-meeting-of-the-european-society-for-hyperthermic-oncology
#6
(no author information available yet)
No abstract text is available yet for this article.
April 12, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29650418/inflammatory-bowel-disease-drastically-affects-the-prognosis-of-patients-treated-for-peritoneal-metastases-with-combined-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-multicenter-study
#7
Nassim Hammoudi, Clarisse Eveno, Jérôme Lambert, Marianne Maillet, Olivier Glehen, Diane Goere, Nelson Lourenco, Matthieu Allez, Thomas Aparicio, Marc Pocard, Jean-Marc Gornet
BACKGROUND: Complete cytoreductive surgery (CCRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a validated treatment in selected patients with peritoneal metastases (PM) of intestinal origin. There is an increased risk of Colorectal Cancer (CRC) and Small Bowel Adenocarcinoma (SBA) in Inflammatory Bowel Disease (IBD). The feasibility and benefit of that surgical approach in IBD patients is unknown. METHODS: IBD patients with operated PM complicating CRC or SBA were extracted from a French national multicenter prospective database of patients who underwent surgery for PM in HIPEC expert centers from 1995 to 2016...
March 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29643552/anaesthetic-management-and-perioperative-outcomes-of-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-a-retrospective-analysis
#8
Kalpana P Balakrishnan, Sreedevi Survesan
Background and Aims: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is becoming the standard treatment option for peritoneal carcinomatosis but is associated with high rates of morbidity and mortality. Our aim was to retrospectively analyse and evaluate intra-operative factors associated with morbidity and mortality of CRS and HIPEC. Methods: Intra-operative data were collected for cases done over 1 year (24 cases) and analysed for the primary outcome of post-operative ventilation >24 h, and secondary outcome of length of the Intensive Care Unit (ICU) stay >5 days...
March 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29643548/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-fluid-and-temperature-remain-the-culprit
#9
EDITORIAL
Rakesh Garg
No abstract text is available yet for this article.
March 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29630093/comment-about-the-hyperthermic-intraoperative-intraperitoneal-chemotherapy-in-the-treatment-of-advanced-abdominopelvic-cancer-personal-experience-on-103-procedures-during-a-seventeen-year-period-in-a-single-italian-center
#10
R Fisichella, A Cappellani, S Berretta
No abstract text is available yet for this article.
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29626594/population-pharmacokinetics-of-oxaliplatin-after-intraperitoneal-administration-with-hyperthermia-in-wistar-rats
#11
M I Mas-Fuster, A Ramon-Lopez, F J Lacueva, A Arroyo, P Más-Serrano, R Nalda-Molina
BACKGROUND: The evaluation of the efficacy and toxicity of hyperthermic intraoperative peritoneal chemotherapy presents some difficulties, due in part to the lack of information about the pharmacokinetic behavior of the drugs administered in this procedure. The aim of this study was to characterize the population pharmacokinetics of hyperthermic intraoperative peritoneal oxaliplatin in Wistar rats and to evaluate the effect of treatment-related covariates dose, instillation time and temperature on the pharmacokinetic parameters...
April 4, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29624505/impact-of-concomitant-urologic-intervention-on-clinical-outcomes-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#12
Akshat Saxena, Winston Liauw, Sohaib A Virk, David L Morris
INTRODUCTION: The impact of concomitant urologic procedures (UPs) on perioperative and long-term outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is uncertain. METHODS: In total, 935 consecutive CRS/HIPEC procedures were performed between 1996 and 2016 in Sydney, Australia. Among these, 73 (7.8%) involved concomitant UP. The association of concomitant UP with 21 perioperative outcomes and overall survival was assessed using univariate and multivariate analyses...
April 5, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29624120/theoretical-investigations-and-density-functional-theory-based-probe-of-the-affinity-interaction-of-saccharide-ligands-with-extra-cellular-sialic-acid-residues
#13
Anjali Patel, Sanjay Tiwari, Prafulla K Jha
Changes in glycosylation pattern leads to malignant transformations among the cells. In combination with upregulated actions of sialyltransferases, it ultimately leads to differential expression of sialic acid (SA) at cell surface. Given its negative charge and localization to extracellular domain, SA has been exploited as a target for the development of targeted theranostics using approaches, such as, cationization and appending recognition saccharides on carrier surface. In this study, we have performed quantum mechanical calculations based on density functional theory (DFT) to study the interaction of saccharides with extracellular SA...
April 6, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29616280/-surgical-treatment-of-peritoneal-metastases-of-gastric-cancer
#14
REVIEW
A Brandl, E Pachmayr, S Gül-Klein, M Alberto, P Thuss-Patience, B Rau
BACKGROUND: Up to 17% of all patients with gastric cancer are diagnosed with the presence of peritoneal metastases, which is associated with a poor prognosis. The most promising results were shown with multimodal treatment regimens including systemic chemotherapy and cytoreductive surgery (CRS). A subsequent hyperthermic intraperitoneal chemotherapy (HIPEC).possibly has a positive effect and is currently being tested. OBJECTIVES: This manuscript highlights the key role of CRS and HIPEC in patients with peritoneal metastases of gastric cancer and illustrates which patients benefit from this intensive therapy...
April 3, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29615881/age-dependent-hypothalamic-and-pituitary-responses-to-novel-environment-stress-or-lipopolysaccharide-in-rats
#15
Sandy Koenig, Janne Bredehöft, Alexander Perniss, Franziska Fuchs, Joachim Roth, Christoph Rummel
Previously, we have shown that the transcription factor nuclear factor interleukin (NF-IL)6 can be used as an activation marker for inflammatory lipopolysaccharide (LPS)-induced and psychological novel environment stress (NES) in the rat brain. Here, we aimed to investigate age dependent changes of hypothalamic and pituitary responses to NES (cage switch) or LPS (100 μg/kg) in 2 and 24 months old rats. Animals were sacrificed at specific time points, blood and brains withdrawn and analyzed using immunohistochemistry, RT-PCR and bioassays...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29603776/selective-bladder-denervation-for-overactive-bladder-oab-syndrome-from-concept-to-healing-outcomes-using-the-ovine-model
#16
James Fugett, Lynette Phillips, Emily Tobin, Eric Whitbrook, Haydon Bennett, Joshua Shrout, James E Coad
AIMS: We evaluated a Selective Bladder Denervation (SBD) device, which uses radiofrequency ablation, for the treatment of overactive bladder syndrome in terms of its nerve denervation, ablation characteristics, and post-treatment healing. METHODS: Using the SBD device, eight fresh extirpated ovine bladder trigones were treated (90°C set point for 60 s) and nitroblue tetrazolium viability stained to characterize the ablation. In addition, 12 trigones were treated in vivo with three adjacent ablations and divided into survival cohorts: Day 7, Day 30, and Day 90 to assess the ablations and their associated healing...
March 31, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29599360/transient-exocrine-pancreatic-insufficiency-first-report-of-an-unrecognized-complication-of-cytoreductive-surgery-and-hipec
#17
Samer A Naffouje, George I Salti
BACKGROUND: As cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are being increasingly adopted as the standard treatment for peritoneal surface malignancies, familiarity with this procedure's adverse events is also growing. Herein, we describe an unreported adverse event of exocrine pancreatic insufficiency (EPI) following CRS and HIPEC. PATIENTS AND METHODS: Patients who underwent CRS and HIPEC between 9/2016 and 9/2017 were prospectively recruited...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29596655/enhanced-hepatic-ppar%C3%AE-activity-links-glut8-deficiency-to-augmented-peripheral-fasting-responses-in-male-mice
#18
Allyson L Mayer, Yiming Zhang, Emily H Feng, Cassandra B Higgins, Oyin Adenekan, Terri A Pietka, Wandy L Beatty, Brian J DeBosch
The adaptive fasting response is invoked as a promising cardiometabolic and neurodegenerative therapeutic pathway. We and others have defined the carbohydrate transporter, GLUT8, as a critical regulator of hepatic and whole-organism metabolic homeostasis in the overfed and diabetic states. However, the functions of this critical transporter in the physiological fasting response remain poorly understood. Here, we tested the hypothesis that GLUT8 modulates the adaptive hepatic fasting response. We demonstrate that mice with targeted Slc2a8 disruption exhibit enhanced thermogenesis, ketogenesis and peripheral lipid mobilization during fasting...
March 26, 2018: Endocrinology
https://www.readbyqxmd.com/read/29596491/core-and-skin-temperature-influences-on-the-surface-electromyographic-responses-to-an-isometric-force-and-position-task
#19
Nico A Coletta, Matthew M Mallette, David A Gabriel, Christopher J Tyler, Stephen S Cheung
The large body of work demonstrating hyperthermic impairment of neuromuscular function has utilized maximal isometric contractions, but extrapolating these findings to whole-body exercise and submaximal, dynamic contractions may be problematic. We isolated and compared core and skin temperature influences on an isometric force task versus a position task requiring dynamic maintenance of joint angle. Surface electromyography (sEMG) was measured on the flexor carpi radialis at 60% of baseline maximal voluntary contraction while either pushing against a rigid restraint (force task) or while maintaining a constant wrist angle and supporting an equivalent inertial load (position task)...
2018: PloS One
https://www.readbyqxmd.com/read/29596098/a-dedicated-acute-pain-service-is-associated-with-reduced-postoperative-opioid-requirements-in-patients-undergoing-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy
#20
Engy T Said, Jacklynn F Sztain, Wendy B Abramson, Minhthy N Meineke, Timothy J Furnish, Ulrich H Schmidt, Gerard R Manecke, Rodney A Gabriel
BACKGROUND: The Acute Pain Service (APS) was initially introduced to optimize multimodal postoperative pain control. The aim of this study was to evaluate the association between the implementation of an APS and postoperative pain management and outcomes for patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). METHODS: In this propensity-matched retrospective cohort study, we performed a before-after study without a concurrent control group...
March 27, 2018: Anesthesia and Analgesia
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