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Hyperthermic

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https://www.readbyqxmd.com/read/28326959/angiosarcoma-of-the-pelvis-in-a-13-year-old-girl
#1
Farah El-Sharkawy, Patricia Isabel Delgado, Antonello Podda, Holly Leigh Neville, Claudia Patricia Rojas
Angiosarcomas are highly aggressive malignancies of vascular origin and are very rarely found in children. We report a case of a 13-year-old girl with a history of abdominal pain and increased abdominal girth. Radiologic imaging showed significant ascites and large pelvic masses involving bilateral adnexa with abdominal spread. Microscopic examination of a biopsy revealed pleomorphic epithelioid and spindle cells with brisk mitotic activity, intracytoplasmic vacuoles, vascular channels, and large areas of hemorrhage and necrosis...
March 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28324285/preoperative-thrombocytosis-predicts-shortened-survival-in-patients-with-malignant-peritoneal-mesothelioma-undergoing-operative-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy
#2
Yue C Li, Tamara Khashab, Julia Terhune, Richard L Eckert, Nader Hanna, Allen Burke, H Richard Alexander
BACKGROUND: This study was designed to determine the clinical significance of preoperative thrombocytosis in patients with malignant peritoneal mesothelioma (MPM) undergoing operative cytoreduction (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). CRS and HIPEC have been associated with prolonged survival in patients with MPM and is the preferred treatment in select patients. However, patient selection criteria remain ill-defined for this operation that is also associated with significant morbidity and mortality...
March 21, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28322970/gold-nanoparticles-radiations-and-the-immune-system-current-insights-into-the-physical-mechanisms-and-the-biological-interactions-of-this-new-alliance-towards-cancer-therapy
#3
REVIEW
Nikolaos M Dimitriou, George Tsekenis, Evangelos C Balanikas, Athanasia Pavlopoulou, Melina Mitsiogianni, Theodora Mantso, George Pashos, Andreas G Boudouvis, Ioannis N Lykakis, Georgios Tsigaridas, Mihalis I Panayiotidis, Vassilios Yannopapas, Alexandros G Georgakilas
Considering both cancer's serious impact on public health and the side effects of cancer treatments, strategies towards targeted cancer therapy have lately gained considerable interest. Employment of gold nanoparticles (GNPs), in combination with ionizing and non-ionizing radiations, has been shown to improve the effect of radiation treatment significantly. GNPs, as high-Z particles, possess the ability to absorb ionizing radiation and enhance the deposited dose within the targeted tumors. Furthermore, they can convert non-ionizing radiation into heat, due to plasmon resonance, leading to hyperthermic damage to cancer cells...
March 16, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28322514/strategies-to-improve-cancer-photothermal-therapy-mediated-by-nanomaterials
#4
REVIEW
Duarte de Melo-Diogo, Cleide Pais-Silva, Diana R Dias, André F Moreira, Ilídio J Correia
The deployment of hyperthermia-based treatments for cancer therapy has captured the attention of different researchers worldwide. In particular, the application of light-responsive nanomaterials to mediate hyperthermia has revealed promising results in several pre-clinical assays. Unlike conventional therapies, these nanostructures can display a preferential tumor accumulation and thus mediate, upon irradiation with near-infrared light, a selective hyperthermic effect with temporal resolution. Different types of nanomaterials such as those based on gold, carbon, copper, molybdenum, tungsten, iron, palladium and conjugated polymers have been used for this photothermal modality...
March 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28319750/unfavorable-effect-of-levetiracetam-on-cultured-hippocampal-neurons-after-hyperthermic-injury
#5
Krzysztof Sendrowski, Piotr Sobaniec, Elżbieta Poskrobko, Małgorzata Rusak, Wojciech Sobaniec
BACKGROUND: The aim of this study was to examine the viability of neurons and the putative neuroprotective effects of second-generation antiepileptic drug, levetiracetam (LEV), on cultured hippocampal neurons injured by hyperthermia. METHODS: Primary cultures of rat's hippocampal neurons at 7day in vitro (DIV) were incubated in the presence or absence of LEV in varied concentrations under hyperthermic conditions. Cultures were heated in a temperature of 40°C for 24h or in a temperature of 41°C for 6h...
January 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28317590/radical-appendectomy-as-an-alternative-to-right-colon-resection-in-patients-with-epithelial-appendiceal-neoplasms
#6
Santiago González-Moreno, Paul H Sugarbaker
OBJECTIVE: Appendectomy is an extremely common surgical procedure usually performed for an inflammatory process within this organ. Upon occasion, the pathology within the appendix is a neoplastic process which requires definitive oncologic management. METHODS: The optimal management strategies for appendiceal neoplasms were reviewed and pertinent literature critically evaluated. The technology for appendectomy for an inflammatory process and an appendectomy for a neoplastic process were compared and contrasted...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28317586/strategies-to-improve-local-control-of-resected-pancreas-adenocarcinoma
#7
Paul H Sugarbaker
BACKGROUND: Only approximately one in ten pancreas cancer patients is a candidate for potentially curative resection of this disease. Even this small fraction of patients has a poor prognosis following pancreatico-duodenectomy. The disease has an anatomic location that makes it difficult for the surgeon to maintain adequate margins of resection and prevent tumor spillage at the time of resection. Also, the disease is biologically aggressive and even with a complete visible resection of the disease, micrometastases are likely to remain behind...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28315061/external-validation-of-the-simplified-preoperative-assessment-for-low-grade-mucinous-adenocarcinoma-of-the-appendix
#8
Vladimir Milovanov, Armando Sardi, Nail Aydin, Carol Nieroda, Michelle Sittig, Vadim Gushchin
BACKGROUND: MD Anderson Cancer Center developed a computed tomography (CT)-based preoperative assessment tool simplified preoperative assessment for appendix tumor (SPAAT) for predicting incomplete cytoreduction (IC) in low-grade mucinous adenocarcinoma (LGMA) of the appendix, based on preoperative CT scans. This study independently evaluates the tool's performance. METHODS: Seventy-six preoperative CT scans of LGMA patients were evaluated by two surgeons unfamiliar with the patients' medical history...
March 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28297683/effects-of-hypothermia-on-the-mechanical-behavior-of-rabbit-femoral-arteries
#9
Kozaburo Hayashi, Yuki Kurose
The need to better understand the effects of non-physiological temperatures on arterial wall behavior is becoming more important because of the increased clinical use of hypothermal and hyperthermal treatments. The present study was performed to examine the effects of temperature on the mechanical behavior of femoral arteries excised from rabbits. Among 17, 27, 37, and 42°C, there were no significant differences in their diameter, stiffness, and P-D relations under the physiologically normal, control condition, although the arterial diameter was slightly smaller at 42°C than at the other three temperatures...
March 6, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28291907/the-effects-of-hyperthermic-intraperitoneal-chemoperfusion-on-colonic-anastomosis-an-experimental-study-in-a-rat-model
#10
Afag Aghayeva, Cigdem Benlice, Ismail Ahmet Bilgin, Pinar Atukeren, Gulen Dogusoy, Figen Demir, Deniz Atasoy, Bilgi Baca
INTRODUCTION: Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model...
February 28, 2017: Tumori
https://www.readbyqxmd.com/read/28289659/single-center-experience-with-hyperthermic-intraperitoneal-chemotherapy
#11
Woo Ram Kim, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Nam Kyu Kim
PURPOSE: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been proposed for controlling peritoneal seeding metastasis in some kinds of cancers, including those of colorectal origin, but their safety and oncological benefits are subjects of debate. We present our early experience with those procedures. METHODS: Data were retrospectively collected from all patients with peritoneal carcinomatosis (PC) and pseudomyxoma peritonei (PMP) treated using CRS and HIPEC at Yonsei Cancer Center between July 2014 and July 2015...
February 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28289655/is-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-safe-and-effective-procedure-for-treating-patients-with-a-peritoneal-surface-malignancy
#12
EDITORIAL
https://www.readbyqxmd.com/read/28282002/the-efficacy-of-dextran-40-as-a-venous-thromboembolism-prophylaxis-strategy-in-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#13
Jason M Foster, Richard Sleightholm, Duncan Watley, Steven Wahlmeier, Asish Patel
The incidence of venous thromboembolism (VTE) in peritoneal malignancies can approach 30 to 50 per cent without prophylaxis. Prophylaxis in cytoreductive surgeries (CRS) presents a challenge to preoperative heparin-based therapy because of an increased risk of coagulopathy and potential for bleeding. Herein, we report the large series of CRS and hyperthermic intraperitoneal chemotherapy receiving dextran-40 prophylaxis. Retrospective chart review of peritoneal malignancies patients undergoing CRS at University of Nebraska Medical Center identified 69 individuals who received dextran-40 between 2010 and 2013...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28280341/a-facile-method-to-prepare-superparamagnetic-iron-oxide-and-hydrophobic-drug-encapsulated-biodegradable-polyurethane-nanoparticles
#14
Kuo-Wei Cheng, Shan-Hui Hsu
Superparamagnetic iron oxide nanoparticles (SPIO NPs) have a wide range of biomedical applications such as in magnetic resonance imaging, targeting, and hyperthermia therapy. Aggregation of SPIO NPs can occur because of the hydrophobic surface and high surface energy of SPIO NPs. Here, we developed a facile method to encapsulate SPIO NPs in amphiphilic biodegradable polymer. Anionic biodegradable polyurethane nanoparticles (PU NPs) with ~35 nm size and different chemistry were prepared by waterborne processes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28274663/is-less-also-better-a-single-institution-experience-on-treatment-of-early-stage-malignant-pleural-mesothelioma
#15
P Bertoglio, M C Ambrogi, A Chella, V Aprile, P Dini, S Korasidis, O Fanucchi, A Mussi
OBJECTIVES: No clear evidence of which surgical procedure should be performed for early stage mesothelioma is available to date. We analyzed our 10-year experience in the treatment of early stage mesothelioma with surgery and Hyperthermic IntraTHOracic Chemotherapy. METHODS: We retrospectively analyzed all cases of histologically proven epithelioid or biphasic IMIG stage I and II mesothelioma that we operated between 2005 and 2014. We performed an open pleurectomy and partial decortication of any visible lesion on the visceral pleura in all cases and both diaphragm and pericardium were always spared; Hyperthermic IntraTHOracic Chemotherapy was ran using Cisplatin 80 mg/m(2) and Doxorubicin 25 mg/m(2) at a target temperature of 42...
February 27, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28273222/exploring-flow-rate-selection-in-hipec-procedures
#16
Thales Paulo Batista, Levon Badiglian Filho, Cristiano Souza Leão
Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a main comprehensive treatment of peritoneal malignancies. However, current data on the literature are very heterogeneous in terms of its technical particularities, which require some efforts to standardization of practices. In these setting, we present some early data from a pioneering clinical trial in Brazil (ClinicalTrials.gov Identifier: NCT02249013) to explore the dynamic relationships between flow rates and temperature parameters in the first cases of our study, which may help in selecting better technical parameters during HIPEC procedures...
December 2016: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28265776/major-postoperative-complications-are-a-risk-factor-for-impaired-survival-after-crs-hipec
#17
Marcel André Schneider, Dilmurodjon Eshmuminov, Kuno Lehmann
BACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is a combined treatment option for well-selected patients with peritoneal carcinomatosis (PC). The study aimed to identify factors influencing cancer-specific survival (CSS) and disease-free survival (DFS). METHODS: Data of 113 patients with colorectal or appendicular carcinomatosis from a single center operated between 2009 and 2014 were retrospectively collected and analyzed...
March 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28256298/contribution-of-mitochondria-to-injury-of-hepatocytes-and-liver-tissue-by-hyperthermia
#18
Rasa Žūkienė, Zita Naučienė, Giedrė Šilkūnienė, Tomas Vanagas, Antanas Gulbinas, Aurelijus Zimkus, Vida Mildažienė
OBJECTIVE: The aim of this study was to investigate functional changes of liver mitochondria within the experimentally modeled transition zone of radiofrequency ablation and to estimate possible contribution of these changes to the energy status of liver cells and the whole tissue. MATERIALS AND METHODS: Experiments were carried out on mitochondria isolated from the perfused liver and isolated hepatocytes of male Wistar rats. Hyperthermia was induced by changing the temperature of perfusion medium in the range characteristic for the transition zone (38-52°C)...
January 9, 2017: Medicina
https://www.readbyqxmd.com/read/28253071/response-to-mynbaev-et-al-re-the-onset-of-intra-abdominal-adhesions-during-closed-abdomen-hyperthermic-intraperitoneal-chemotherapy
#19
Marco Lotti
No abstract text is available yet for this article.
March 2, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28253052/re-the-onset-of-intra-abdominal-adhesions-during-closed-abdomen-hyperthermic-intraperitoneal-chemotherapy-j-laparoendosc-adv-surg-tech-a-2016-26-997-1002
#20
Ospan A Mynbaev, Alexey A Ivanov, Tahar Benhidjeb, Michael Stark
No abstract text is available yet for this article.
March 2, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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