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https://www.readbyqxmd.com/read/27906837/different-impacts-of-hypertension-and-diabetes-mellitus-on-all-cause-and-cardiovascular-mortality-in-community-dwelling-older-adults-the-rancho-bernardo-study
#1
Jee-Young Oh, Matthew A Allison, Elizabeth Barrett-Connor
OBJECTIVES: Although the prevalence rates of hypertension (HTN) and diabetes mellitus are slowing in some high-income countries, HTN and diabetes mellitus remain as the two major risk factors for atherosclerotic cardiovascular disease (CVD), the leading cause of death in the United States and worldwide. We aimed to observe the association of HTN and diabetes mellitus with all-cause and CVD mortality in older white adults. METHODS: All community-dwelling Rancho Bernardo Study participants who were at least 55 years old and had carefully measured blood pressure and plasma glucose from 75-g oral glucose tolerance test at the baseline visit (1984-1987, n = 2186) were followed up until death or the last clinic visit in 2013 (median 14...
January 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27892612/the-prevalence-of-depressive-symptoms-among-older-patients-with-hypertension-in-rural-china
#2
Jiang Xue, Shulin Chen, Hillary R Bogner, Wan Tang, Lydia Li, Yeates Conwell
OBJECTIVE: The comorbidity of depression and hypertension (HTN) is common and complicates the management of both conditions. This study investigated the prevalence of depressive symptoms among older patients with HTN in rural China and explored the relationship between the two conditions. METHODS: The baseline data of older patients diagnosed with HTN included in the depression/HTN in Chinese Older Adults-Collaborations for Health Study were used for the analysis...
November 28, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27891612/neurovascular-mechanisms-underlying-augmented-cold-induced-reflex-cutaneous-vasoconstriction-in-human-hypertension
#3
Jody L Greaney, W Larry Kenney, Lacy M Alexander
Despite ample evidence of dysregulated sympathetic control of the peripheral vasculature in hypertension, no studies have examined integrated neurovascular function during cold stress in hypertensive adults (HTN). We hypothesized that (1) whole-body cooling would elicit greater cutaneous vasoconstriction and greater increases in skin sympathetic nervous system activity (SSNA) in HTN (n = 14; 56 ± 2 yrs) compared to age-matched normotensive adults (NTN; n = 14; 55 ± 2 yrs) and (2) augmented reflex vasoconstriction in HTN would be mediated by an increase in cutaneous vascular adrenergic sensitivity and a greater contribution of non-adrenergic sympathetic co-transmitters...
November 28, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27882930/hypertension-is-an-important-risk-determinant-for-chronic-kidney-disease-results-from-a-cross-sectional-observational-study-from-a-rural-population-in-south-india
#4
Y J Anupama, S N Hegde, G Uma, M Patil
Hypertension (HTN) is an important cause for chronic kidney disease (CKD). There is a paucity of studies exploring the association of HTN with CKD from rural India. The objective of the study was to determine the prevalence and the determinants for HTN in a rural population in South India, focusing on the association with CKD. In a cross-sectional study on 2984 adults in three villages, demographic and anthropometric data were collected. Blood pressure was recorded on all individuals and prevalence was estimated...
November 24, 2016: Journal of Human Hypertension
https://www.readbyqxmd.com/read/27882291/comparison-of-body-mass-index-waist-circumference-and-waist-to-height-ratio-in-the-prediction-of-hypertension-and-diabetes-mellitus-filipino-american-women-cardiovascular-study
#5
Cynthia A Battie, Nancy Borja-Hart, Irma B Ancheta, Rene Flores, Goutham Rao, Latha Palaniappan
The relative ability of three obesity indices to predict hypertension (HTN) and diabetes (DM) and the validity of using Asian-specific thresholds of these indices were examined in Filipino-American women (FAW). Filipino-American women (n = 382), 40-65 years of age were screened for hypertension (HTN) and diabetes (DM) in four major US cities. Body mass index (BMI), waist circumference (WC) and waist circumference to height ratio (WHtR) were measured. ROC analyses determined that the three obesity measurements were similar in predicting HTN and DM (AUC: 0...
December 2016: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27881848/expression-and-methylation-of-circulating-microrna-510-in-essential-hypertension
#6
Ramalingam Krishnan, Panagal Mani, Pethanen Sivakumar, Vincent Gopinath, Durairaj Sekar
Hypertension (HTN) is one of the most common emerging disease in developing countries. It alters endothelial cell structure and function, resulting in several diseases, such as cardiovascular disease, peripheral vasculopathy, cerebrovascular disease and nephropathy. Although much progress has been made in researching HTN in recent years, early diagnosis and treatment of HTN are not yet satisfactory, and progression control/treatment is still poor. MicroRNAs are well-known regulators of the physiological and developmental processes of HTN...
November 24, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27881062/antihypertensive-treatments-in-patients-affected-by-aortic-valve-stenosis
#7
Paolo Poggio, Gianluca Folesani, Giuseppe M Raffa, Paola Songia, Vincenzo Valenti, Veronika Myasoedova, Alessandro Parolari
Systemic hypertension and aortic valve stenosis (AVS) are both age-related diseases. Severe aortic stenosis affects ≈2% to 5% of adults age > 65 years. Systemic hypertension (HTN) is a frequent comorbidity in patients with AVS and is coexistent for a longer period of time before AVS is treated. Essential systemic hypertension, per se, plays an important role in the creation of lesions on the aortic side of the valve, the region of higher exposure to tension stress. The subsequent endothelial defect represents the principal site of inflammatory process and oxidative stress, leading to aortic sclerosis and calcification...
November 23, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27872696/incidence-and-clinical-outcome-of-patients-with-hypertensive-acute-ischemic-stroke-an-update-from-tertiary-care-center-of-central-india
#8
Amit R Nayak, Seema D Shekhawat, Neha H Lande, Anuja P Kawle, Dinesh P Kabra, Nitin H Chandak, Shweta R Badar, Dhananjay V Raje, Hatim F Daginawala, Lokendra R Singh, Rajpal S Kashyap
INTRODUCTION: We evaluated the incidence and clinical outcome of patients with hypertensive acute ischemic stroke (AIS) admitted to a tertiary care center in Central India. In addition, we examined the status of stroke biomarkers namely neuron-specific enolase (NSE), glial specific protein (S-100ββ), and inter-α-trypsin inhibitor heavy chain 4(ITIH4) in the serum of patients suffering from AIS with hypertension (HTN) and without HTN. METHODS: A total of 104 patients with AIS were enrolled for the study...
October 2016: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/27867112/hydrogel-thickened-nanoemulsions-based-on-essential-oils-for-topical-delivery-of-psoralen-permeation-and-stability-studies
#9
Thaís Nogueira Barradas, Juliana Perdiz Senna, Stephani Araujo Cardoso, Sara Nicoli, Cristina Padula, Patrizia Santi, Francesca Rossi, K Gyselle de Holanda E Silva, Claudia R Elias Mansur
Nanoemulsions (NE) have attracted much attention due to their as dermal delivery systems for lipophilic drugs such as psoralens. However, NE feature low viscosity which might be unsuitable for topical application. In this work, we produced hydrogel-thickened nanoemulsions (HTN) using chitosan as thickening polymer to overcome the low viscosity attributed to NE. The aim of this study is to develop and characterize oil-in-water (o/w) HTN based on sweet fennel and clove essential oil to transdermal delivery of 8-methoxsalen (8-MOP)...
November 17, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27847154/primary-hyperparathyroidism-predicts-hypertension-results-from-the-national-inpatient-sample
#10
A Kalla, P Krishnamoorthy, A Gopalakrishnan, J Garg, N C Patel, V M Figueredo
INTRODUCTION: Primary hyperparathyroidism (pHPT), most commonly caused by solitary parathyroid adenomas, leads to mobilization of calcium and is known to result in nephrolithiasis and osteoporosis. To date, studies of pHPT and cardiovascular risk factors and events have produced discrepant findings, likely due to small sample sizes and enrolling populations with varying disease severity. HYPOTHESIS: We utilized a national registry, hypothesizing an association between pHPT and cardiovascular risk factors and events...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27843947/relationship-between-interdialytic-weight-gain-and-blood-pressure-in-pediatric-patients-on-chronic-hemodialysis
#11
Olivera Marsenic, Michael Anderson, Kevin G Couloures
Overhydration is reported to be the main cause of hypertension (HTN) as well as to have no association with HTN in hemodialysis (HD) population. This is the first report of the relationship between interdialytic weight gain (IDWG) and pre-HD blood pressure (BP) in pediatric patients in relation to residual urine output (RUO). We studied 170 HD sessions and interdialytic periods performed during a 12-week period in 5 patients [age 4-17 years, weight 20.8-66 kg, 3 anuric (102 HD sessions), and 2 nonanuric (68 HD sessions)]...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27843607/association-between-bevacizumab-related-hypertension-and-response-to-treatment-in-patients-with-metastatic-colorectal-cancer
#12
Isabel José Dionísio de Sousa, Joana Ferreira, Joana Rodrigues, Nuno Bonito, Paula Jacinto, Mariela Marques, João Ribeiro, Ana Pais, Helena Gervásio
BACKGROUND: Bevacizumab has become standard of care as first-line treatment of metastatic colorectal cancer (mCRC), after proving increased response rates and improvement in survival outcomes. Hypertension (HTN) is a common complication of the treatment with bevacizumab and, owing to its close relation with antiangiogenic mechanism, may represent a clinical biomarker to predict the efficacy of the treatment. The aim of this study was to retrospectively evaluate if HTN grades 2 to 3 were correlated with response to treatment with bevacizumab in first line, as well as with improved progression-free survival (PFS) and overall survival (OS), in a series of patients with mCRC...
2016: ESMO Open
https://www.readbyqxmd.com/read/27823680/hypertension-in-adults-with-repaired-coarctation-of-the-aorta
#13
Daniel Rinnström, Mikael Dellborg, Ulf Thilén, Peder Sörensson, Niels-Erik Nielsen, Christina Christersson, Bengt Johansson
AIMS: In adults with coarctation of the aorta (CoA), hypertension (HTN) is a common long-term complication. We investigated the prevalence of HTN and analyzed factors associated with HTN. METHODS AND RESULTS: In the national register for congenital heart disease, 653 adults with repaired CoA were identified (mean age 36.9±14.4years); 344 (52.7%) of them had HTN, defined as either an existing diagnosis or blood pressure (BP) ≥140/90mmHg at the clinical visit. In a multivariable model, age (years) (odds ratio [OR] 1...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27822022/sex-specific-predictors-of-left-ventricular-diastolic-dysfunction-in-untreated-hypertension
#14
Joanna Jaroch, Olga Vriz, Zbigniew Bociąga, Caterina Driussi, Maria Łoboz-Rudnicka, Barbara Rzyczkowska, Krystyna Łoboz-Grudzień
BACKGROUND: Little is known about the sex-specific differences in left ventricular (LV) diastolic dysfunction (DD) predictors. We hypothesized that arterial stiffness (AS) may play a different role in the etiology of LV DD in hypertensive men and postmenopausal women, acting independently from other established predictors of this condition, such as age, obesity, diabetes mellitus, LV remodeling, and systolic function. OBJECTIVES: The aim of the study was to analyze the sex-specific differences in AS and other predictors of LV DD in men and postmenopausal women with untreated hypertension (HTN)...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27812514/association-between-genetic-variations-affecting-mean-telomere-length-and-the-prevalence-of-hypertension-and-coronary-heart-disease-in-koreans
#15
Jean Kyung Paik, Ryungwoo Kang, Yoonsu Cho, Min-Jeong Shin
In this study, we investigated whether the single nucleotide polymorphisms (SNPs) associated with telomere length (TL) were associated with the incidence of hypertension (HTN)/coronary heart disease (CHD) and cardiovascular risk factors in the Korean population. Data from 5,705 (ages 39-70) participants in the Korean Genome Epidemiology Study (rural Ansung and urban Ansan cohorts) were studied. Twelve SNPs known to be associated with telomere biology were tested for an association with HTN/CHD. As results, no significant associations were found between the selected TL-related SNPs and prevalence of HTN and CHD...
October 2016: Clinical Nutrition Research
https://www.readbyqxmd.com/read/27809339/clinical-significance-of-nonsustained-ventricular-tachycardia-on-stored-electrograms-in-permanent-pacemaker-patients
#16
James Gabriels, Michael Wu, Lisa Rosen, Apoor Patel, Bruce Goldner
BACKGROUND: Permanent pacemaker electrograms record a variety of arrhythmias, including nonsustained ventricular tachycardia (NSVT). Little has been reported regarding incidence and clinical significance of NSVT in pacemaker patients after long-term monitoring. METHODS: Records from all patients implanted with Medtronic pacemakers (Medtronic, Minneapolis, MN, USA) at a single institution from January 1, 2009 to February 27, 2012 were reviewed. Demographic characteristics, imaging studies, pacemaker interrogations, and the Social Security Death Index were examined in patients older than 18 years of age who had ≥ 2 follow-up device interrogations...
November 3, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27806472/analytical-assessment-of-belief-about-medicine-among-patients-with-hypertension-a-case-study-on-patients-referred-to-medical-centers
#17
Mohammad Edris Arbabshastan, Azizollah Arbabisarjou, Iraj Zareban, Mahlagha Dehghan, Saeed Pakdel, Sedigheh Iranmanesh
INTRODUCTION & OBJECTIVE: Hypertension (HTN) is one of the major health problems in many countries. Medicinal treatments and lifestyle modification have so far failed to effectively influence blood pressure control. Hence, this study intended to analytically assess the belief about medicine among hypertensive patients who referred to medical centers during 2015. MATERIALS & METHODS: This was a descriptive-analytical, cross-sectional study. The population consisted of all patients who referred to health centers and doctors' offices for internal medicine and heart diseases...
June 30, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27804237/association-between-pulse-pressure-and-body-mass-index-in-hypertensive-and-normotensive-populations-in-the-korea-national-health-and-nutrition-examination-survey-v-2010-2012
#18
Min Gyu Kang, Kye-Hwan Kim, Jin-Sin Koh, Jeong Rang Park, Seok-Jae Hwang, Jin-Yong Hwang, Jong Hwa Ahn, Jeong Yoon Jang, Young-Hoon Jeong, Choong Hwan Kwak, Hyun Woong Park
The authors conducted a national cross-sectional cohort study to evaluate the associations between pulse pressure (PP) and body mass index (BMI) and sex, according to blood pressure (BP) status. A total of 18 812 patients without a history of antihypertensive medication and cardiovascular disease were selected. There was good concordance between PP and the selected cardiovascular risk factors. PP increased with high BMI among patients with normal BP, but decreased with high BMI among patients with hypertension (HTN)...
November 2, 2016: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/27797437/screening-and-treatment-for-subclinical-hypertensive-heart-disease-in-emergency-department-patients-with-uncontrolled-blood-pressure-a-cost-effectiveness-analysis
#19
Michael J Twiner, Alexander L Marinica, Kenneth Kuper, Allen Goodman, James J Mahn, Michael J Burla, Aaron M Brody, Justin A Carroll, Robina Josiah Willock, John M Flack, Samar A Nasser, Phillip Levy
OBJECTIVES: Poorly controlled hypertension (HTN) is extremely prevalent and if left unchecked, subclinical hypertensive heart disease (SHHD) may ensue leading to conditions such as heart failure (HF). To address this, we designed a multidisciplinary program to detect and treat SHHD in a high-risk, predominantly African American community. The primary objective of this study was to determine the cost effectiveness of our program. METHODS: Study costs associated with identifying and treating patients with SHHD were calculated and a sensitivity analysis was performed comparing the effect of four parameters on cost estimates...
October 31, 2016: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/27796865/hypertension-in-patients-with-heart-failure-with-reduced-ejection-fraction
#20
REVIEW
Massimo Volpe, Caterina Santolamazza, Giuliano Tocci
Hypertension (HTN) is a well-known health problem associated with considerable morbidity and mortality and it is an important risk factor for the development of heart failure (HF). These findings support the need for optimizing the antihypertensive strategies to prevent the progression to HF. Interestingly, the progression from HTN to HF, among other things, may be a consequence of inappropriate over-activation of the renin-angiotensin-aldosterone system (RAAS), sympathetic nervous system (SNS), and the natriuretic peptide system (NPS)...
December 2016: Current Cardiology Reports
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