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hyperthermia cancer

Taoufik Ladhari, Konrad Szafnicki
Usual therapies against malignant tumors, such as surgery, chemotherapy, radiation, is severe and when repeated their efficiency may decrease because tumorous cells may become resistant. Contrarily, hyperthermia has been known for some time as an effective auxiliary treatment, which can be applied repeatedly. In some cases of abdominal carcinomatosis, particularly those of digestive origin, HIPEC is considered as an promising therapeutic option. Chemotherapy and hyperthermia are combined via the perfusion of the abdominal cavity with hot fluids containing chemotherapeutic agents, thus, augmenting the influence of appropriate chemotherapeutic agents with heat...
April 2018: 3 Biotech
Vaidotas Cesna, Arturas Sukovas, Aldona Jasukaitiene, Rima Naginiene, Giedrius Barauskas, Zilvinas Dambrauskas, Saulius Paskauskas, Antanas Gulbinas
AIM: To investigate the response to hyperthermia and chemotherapy, analyzing apoptosis, cytotoxicity, and cisplatin concentration in different digestive system cancer cells. METHODS: AGS (gastric cancer cell line), Caco-2 (colon cancer cell line) and T3M4 (pancreatic cancer cell line) were treated by cisplatin and different temperature setting (37 °C to 45 °C) either in isolation, or in combination. Treatment lasted for one hour. 48 h after the treatment viability was evaluated by MTT, cell apoptosis by Annexin V-PE and 7ADD flow cytometry...
March 14, 2018: World Journal of Gastroenterology: WJG
Eduardo Guisasola, Laura Asín, Lillianne Beola, Jesús M De La Fuente, Alejandro Baeza, María Vallet Regí
This work presents an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles (MMSNs). This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated with an engineered thermoresponsive polymer. The magnetic nanoparticles act as internal heating sources under an alternating magnetic field (AMF) that increase the temperature of the surroundings, provoking the polymer transition and consequently the release of a drug trapped inside the silica pores...
March 21, 2018: ACS Applied Materials & Interfaces
Katarzyna Kaczmarek, Tomasz Hornowski, Martina Kubovcíkova, Milan Timko, Marceli Koralewski, Arkadiusz Józefczak
The efficiency of ultrasound hyperthermia for anti-cancer treatments such as radiotherapy or chemotherapy can be improved by using sonosensitizers, which are materials that enhance the attenuation and dissipation of acoustic energy. We propose the use of magnetic nanoparticles as sonosensitizers because of their biocompatibility, non-toxicity, and common use in several medical applications. A magnetic material was synthetized and then incorporated in the form of a magnetic fluid in agar tissue-mimicking phantoms...
March 21, 2018: ACS Applied Materials & Interfaces
Shahbaz Ahmad Zakki, Zheng-Guo Cui, Lu Sun, Qian-Wen Feng, Meng-Ling Li, Hidekuni Inadera
BACKGROUND/AIMS: Hyperthermia is a widely used therapeutic tool for cancer therapy and a well-known inducer of apoptosis. Although the flavonoid compound baicalin (BCN) is a potent anticancer agent for several human carcinomas, it is less potent in the human U937 myelomonocytic leukemia cell line. To explore any enhancing effects of BCN on hyperthermia-induced apoptosis, this study investigated the combined effects and apoptotic mechanisms of hyperthermia and BCN in U937 cells. METHODS: U937 cells were heat treated at 44ºC for 12 min with or without pre-treatment with BCN (10-50 µM) and then incubated for 6 h at 37 ºC with 5% CO2 and 95% air...
March 15, 2018: Cellular Physiology and Biochemistry
Lu Sun, Zheng-Guo Cui, Shahbaz Ahmad Zakki, Qian-Wen Feng, Meng-Ling Li, Hidekuni Inadera
Hyperthermia is one therapeutic tool for damaging and killing cancer cells, with minimal injury to normal tissues. However, its cytotoxic effects alone are insufficient for quantitative cancer cell death. To overcome this limitation, several studies have explored non-toxic enhancers for hyperthermia-induced cell death. Capsaicin may be applicable as a therapeutic tool against various types of cancer. In the present study, we employed nonivamide, a less-pungent capsaicin analogue, to investigate its possible enhancing effects on hyperthermia-induced apoptosis; moreover, we analyzed its molecular mechanism...
March 15, 2018: Free Radical Biology & Medicine
Francisco Pelaez, Navid Manuchehrabadi, Priyatanu Roy, Harishankar Natesan, Yiru Wang, Emilian Racila, Heather Fong, Kevin Zeng, Abby M Silbaugh, John C Bischof, Samira M Azarin
Currently, there are very few therapeutic options for treatment of metastatic disease, as it often remains undetected until the burden of disease is too high. Microporous poly(ε-caprolactone) biomaterials have been shown to attract metastasizing breast cancer cells in vivo early in tumor progression. In order to enhance the therapeutic potential of these scaffolds, they were modified such that infiltrating cells could be eliminated with non-invasive focal hyperthermia. Metal disks were incorporated into poly(ε-caprolactone) scaffolds to generate heat through electromagnetic induction by an oscillating magnetic field within a radiofrequency coil...
February 28, 2018: Biomaterials
Akhila Jose, Mrudula Surendran, Sajid Fazal, Bindhu-Paul Prasanth, Deepthy Menon
This work reports the potential of iron quantum clusters (FeQCs) as a hyperthermia agent for cancer, by testing its in-vitro response to shortwave (MHz range), radiofrequency (RF) waves non-invasively. Stable, fluorescent FeQCs of size ∼1 nm prepared by facile aqueous chemistry from endogenous protein haemoglobin were found to give a high thermal response, with a ΔT ∼50 °C at concentrationsas low as165 μg/mL. The as-prepared nanoclusters purified by lyophilization as well as dialysis showed a concentration, power and time-dependent RF response, with the lyophilized FeQCs exhibiting pronounced heating effects...
February 27, 2018: Colloids and Surfaces. B, Biointerfaces
Lin Chen, Huan Zhang, Jing Zheng, Shiping Yu, Jinglei Du, Yongzhen Yang, Xuguang Liu
A multifunctional nanoplatform based on thermo-sensitively and magnetically ordered mesoporous carbon nanospheres (TMOMCNs) is developed for effective targeted controlled release of doxorubicin hydrochloride (DOX) and hyperthermia in this work. The morphology, specific surface area, porosity, thermo-stability, thermo-sensitivity, as well as magnetism properties of TMOMCNs were verified by high resolution transmission electron microscopy, field emission scanning electron microscopy, thermo-gravimetric analysis, X-ray diffraction, Brunauer-Emmeltt-Teller surface area analysis, dynamic light scattering and vibrating sample magnetometry measurement...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
H P Kok, F Navarro, L Strigari, M Cavagnaro, J Crezee
BACKGROUND: Locoregional hyperthermia is applied to deep-seated tumors in the pelvic region. Two very different heating techniques are often applied: capacitive and radiative heating. In this paper numerical simulations are applied to compare the performance of both techniques in heating of deep-seated tumors. METHODS: Phantom simulations were performed for small (30x20x50cm3 ) and large (45x30x50cm3 ), homogeneous fatless and inhomogeneous fat-muscle, tissue-equivalent phantoms with a central or eccentric target region...
March 6, 2018: International Journal of Hyperthermia
David Cabrera, Annelies Coene, Jonathan Leliaert, Emilio J Artés-Ibáñez, Luc Dupré, Neil D Telling, Francisco J Teran
Magnetic nanoparticles exposed to alternating magnetic fields have shown a great potential acting as magnetic hyperthermia mediators for cancer treatment. However, a dramatic and unexplained reduction of the nanoparticle magnetic heating efficiency has been evidenced when nanoparticles are located inside cells or tissues. Recent studies suggest the enhancement of nanoparticle clustering and/or immobilization after interaction with cells as possible causes, although a quantitative description of the influence of biological matrices on the magnetic response of magnetic nanoparticles under AC magnetic fields is lacking...
March 6, 2018: ACS Nano
Oihane K Arriortua, Maite Insausti, Luis Lezama, Izaskun Gil de Muro, Eneko Garaio, Jesus Martínez de la Fuente, Raluca M Fratila, Maria P Morales, Rocío Costa, Maite Eceiza, Maialen Sagartzazu-Aizpurua, Jesus M Aizpurua
To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3 O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a "click" chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target αv β3 integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements...
February 15, 2018: Colloids and Surfaces. B, Biointerfaces
Mostafa Pasandi Boroon, Mohammad-Bagher Ayani, Sajad Razavi Bazaz
Hyperthermia is one of the most appealing methods of cancer treatment in which the temperature of tumor is elevated to reach a desired temperature. One of the methods of increasing tissue temperature is injection of nanoparticle fluids to tumor and applying alternative magnetic field, which is called magnetic nanoparticle hyperthermia method. The total number of injection points, as well as the their location within a tissue play a significant role in this method. Furthermore, the power of heating of a magnetic material per gram or specific loss power (SLP) is another important factor which needs to be investigated...
February 2018: Journal of Thermal Biology
Hasan Norouzi, Karim Khoshgard, Fatemeh Akbarzadeh
Hyperthermia is an anti-cancer treatment in which the temperature of the malignant tumor is increased more than other adjacent normal tissues. Microwave, ultrasound, laser, and radiofrequency sources have been used for hyperthermia of cancerous tissues. In the past decade, near-infrared (NIR) laser for cancer therapy, known as photo-thermal therapy (PTT), was expanded in which the photo-sensitizer agent converts the light photon energy to heat. The heat following PTT can destroy cancer cells. There are some photo-sensitizer agents which have been used for PTT; however, owing to recent advances in nanotechnology, noble metal nanoparticles like gold (Au) nanoparticles (GNPs) have been used successfully in PTT...
February 28, 2018: Lasers in Medical Science
Mariko Ishizuka, Yu Tsubota, Aiko Ueda, Noriko Sueoka, Katsuhiro Yoshikawa, Daigo Yamamoto
Advanced breast cancer has a poor prognosis compared to early breast cancer; however, quality of life and radical operation can be improved in some case by using multidisciplinary treatment. A 54-year-old woman was examined at the hospital because of an enlarging tumor in the left breast. She was aware of a lump for 3 years. Results of the initial examination indicated invasive ductal carcinoma with liver metastasis. She first received chemotherapy(AC followed by weekly paclitaxel). After 4 courses of weekly paclitaxel, computed tomography revealed axillary lymph nodes involved in the axillary vein...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Massimo Bonucci, Carlo Pastore, Vincenzo Ferrera, Carla Fiorentini, Alessia Fabbri
Pancreatic cancer (PC) has a very low average survival, but its prognosis is further reduced in the case of metastatic spread. Medical therapy in these cases is the only applicable methodology in the international guidelines. During anticancer treatments, common side effects are nausea, vomiting, arthralgia, neuropathy, and alopecia as well as a myelosuppressive effect. The toxicity of various drugs not only affects the quality of life of the patient, but often its severity requires a reduction in if not the termination of drug administration...
February 1, 2018: Integrative Cancer Therapies
Jared M Newton, Jose H Flores-Arredondo, Sarah Suki, Matthew J Ware, Martyna Krzykawska-Serda, Mahdi Agha, Justin J Law, Andrew G Sikora, Steven A Curley, Stuart J Corr
Previous work using non-invasive radiofrequency field treatment (RFT) in cancer has demonstrated its therapeutic potential as it can increase intratumoral blood perfusion, localization of intravenously delivered drugs, and promote a hyperthermic intratumoral state. Despite the well-known immunologic benefits that febrile hyperthermia can induce, an investigation of how RFT could modulate the intra-tumoral immune microenvironment had not been studied. Thus, using an established 4T1 breast cancer model in immune competent mice, we demonstrate that RFT induces a transient, localized, and T-cell dependent intratumoral inflammatory response...
February 22, 2018: Scientific Reports
Samuel D Oberdick, Ahmed Abdelgawad, Carlos Moya, Samaneh Mesbahi-Vasey, Demie Kepaptsoglou, Vlado K Lazarov, Richard F L Evans, Daniel Meilak, Elizabeth Skoropata, Johan van Lierop, Ian Hunt-Isaak, Hillary Pan, Yumi Ijiri, Kathryn L Krycka, Julie A Borchers, Sara A Majetich
Magnetic nanoparticles (MNPs) have become increasingly important in biomedical applications like magnetic imaging and hyperthermia based cancer treatment. Understanding their magnetic spin configurations is important for optimizing these applications. The measured magnetization of MNPs can be significantly lower than bulk counterparts, often due to canted spins. This has previously been presumed to be a surface effect, where reduced exchange allows spins closest to the nanoparticle surface to deviate locally from collinear structures...
February 21, 2018: Scientific Reports
Zhila Rajaee, Samideh Khoei, Seied Rabi Mahdavi, Marzieh Ebrahimi, Sakine Shirvalilou, Alireza Mahdavian
The aim of this study was to investigate the effect of hyperthermia, 6 MeV electron radiation and combination of these treatments on cancer cell line DU145 in both monolayer culture and spheroids enriched for prostate cancer stem cells (CSCs). Flowcytometric analysis of the expression of molecular markers CD133+ /CD44+ was carried out to determine the prostate CSCs in cell line DU145 grown as spheroids in serum-free medium. Following monolayer and spheroid culture, DU145 cells were treated with different doses of hyperthermia, electron beam and combination of them...
February 17, 2018: Radiation and Environmental Biophysics
Rolf D Issels, Lars H Lindner, Jaap Verweij, Rüdiger Wessalowski, Peter Reichardt, Peter Wust, Pirus Ghadjar, Peter Hohenberger, Martin Angele, Christoph Salat, Zeljko Vujaskovic, Soeren Daugaard, Olav Mella, Ulrich Mansmann, Hans Roland Dürr, Thomas Knösel, Sultan Abdel-Rahman, Michael Schmidt, Wolfgang Hiddemann, Karl-Walter Jauch, Claus Belka, Alessandro Gronchi
Importance: Patients with soft tissue sarcoma are at risk for local recurrence and distant metastases despite optimal local treatment. Preoperative anthracycline plus ifosfamide chemotherapy improves outcome in common histological subtypes. Objective: To analyze whether the previously reported improvement in local progression-free survival by adding regional hyperthermia to neoadjuvant chemotherapy translates into improved survival. Design, Setting, and Participants: Open-label, phase 3 randomized clinical trial to evaluate the efficacy and toxic effects of neoadjuvant chemotherapy plus regional hyperthermia...
February 15, 2018: JAMA Oncology
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