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https://www.readbyqxmd.com/read/28733865/checkpoint-kinase-2-is-dispensable-for-regulation-of-the-p53-response-but-is-required-for-g2-m-arrest-and-cell-survival-in-cells-with-p53-defects-under-heat-stress
#1
Yukihiro Furusawa, Yuka Yamanouchi, Takashi Iizumi, Qing-Li Zhao, Yohei Mitsuhashi, Akinori Morita, Atushi Enomoto, Yoshiaki Tabuchi, Takashi Kondo
Hyperthermia induced by heat stress (HS) is known to inhibit proliferation and induce cell death in cancer. We previously demonstrated that checkpoint kinase 1 (Chk1) contributes to G2/M arrest and cell survival under HS; however, the role of Chk2, a functional analog of Chk1, in regulation of the cell cycle and cell death under HS is still unknown. Here, we addressed the role of Chk2 using Molt-4 cells with p53-targeted shRNA (Molt-4/shp53) and parental control cells (Molt-4/V). Chk2 inhibition suppressed C-terminal acetylation of p53 and delayed the induction of p53-target genes in Molt-4/V cells under HS; however, Chk2 inhibition failed to inhibit apoptosis induced by HS, indicating that Chk2 was dispensable for p53-dependent apoptosis under HS...
July 21, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28732311/solid-and-aqueous-magnetoliposomes-as-nanocarriers-for-a-new-potential-drug-active-against-breast-cancer
#2
Ana Rita O Rodrigues, Pedro M F Mendes, Pedro M L Silva, V A Machado, Bernardo G Almeida, J P Araújo, Maria-João R P Queiroz, Elisabete M S Castanheira, Paulo J G Coutinho
Iron oxide nanoparticles, with diameters around 12nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7Oe and a blocking temperature of 118K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28731175/heat-shock-induced-hikeshi-protects-cell-viability-via-nuclear-translocation-of-heat-shock-protein-70
#3
Toru Yanoma, Kyoichi Ogata, Takehiko Yokobori, Munenori Ide, Erito Mochiki, Yoshitaka Toyomasu, Mitsuhiro Yanai, Norimichi Kogure, Akiharu Kimura, Masaki Suzuki, Nobuhiro Nakazawa, Tuya Bai, Tetsunari Oyama, Takayuki Asao, Ken Shirabe, Hiroyuki Kuwano
Heat shock proteins (HSPs), particularly HSP70, help restore normal cellular function following damage caused by stressors. HSP expression in tumor tissues indicates cancer progression, and while the development of HSP inhibitors is progressing, these substances are not widely used to treat cancer. HIKESHI (C11orf73) does not control the intracellular movement of HSP70 at normal temperatures; however, it does regulate the function and movements of HSP70 during heat shock. In this study, we examined the intracellular movement of HSP70 during heat shock to investigate the significance of HIKESHI expression in gastric cancer (GC) and determine if HIKESHI inhibition has cytotoxic effects...
July 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28726937/novel-nanoparticles-with-cr-3-substituted-ferrite-for-self-regulating-temperature-hyperthermia
#4
Wei Zhang, Xudong Zuo, Ying Niu, Chengwei Wu, Shuping Wang, Shui Guan, S Ravi P Silva
For hyperthermia to be used under clinical conditions for cancer therapeutics the temperature regulation needs to be precise and accurately controllable. In the case of the metal nanoparticles used for such activities, a high coercivity is a prerequisite in order to couple more energy in a single heating cycle for efficient and faster differential heating. The chemically stable Co-Zn ferrite nanoparticles have typically not been used in such self-regulating hyperthermia temperature applications to date due to their low Curie temperature usually accompanied by a poor coercivity...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28723064/doxorubicin-intracellular-remote-release-from-biocompatible-oegma-based-magnetic-nanogels-triggered-by-magnetic-hyperthermia
#5
Esther Cazares-Cortes, Ana Espinosa, Jean-Michel Guigner, Aude Michel, Nébéwia Griffete, Claire Wilhelm, Christine Menager
Hybrid nanogels, composed of thermoresponsive polymers and superparamagnetic nanoparticles (MNPs) are attractive nanocarriers for biomedical applications, being able - as polymer matrix - to uptake and release high quantities of chemotherapeutic agents and - as magnetic nanoparticles - to heat when exposed to an alternative magnetic field (AMF), better known as magnetic hyperthermia. Herein, biocompatible, pH-, magnetic- and thermo-responsive nanogels, based on oligo (ethylene glycol) methacrylate monomers (OEGMAs) and methacrylic acid co-monomer (MAA) were prepared by conventional precipitation radical co-polymerization in water, post-assembled by complexation with iron oxide magnetic nanoparticles (MNPs) of maghemite (-Fe2O3) and loaded with an anticancer drug (doxorubicin - DOX), for remotely controlled drug release by "hot-spot", as an athermal magnetic hyperthermia strategy against cancer...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28722819/self-targeting-immune-transparent-plasma-protein-coated-nanocomplex-for-noninvasive-photothermal-anticancer-therapy
#6
Fwu-Long Mi, Thierry Burnouf, Shih-Yuan Lu, Yu-Jen Lu, Kun-Ying Lu, Yi-Cheng Ho, Chang-Yi Kuo, Er-Yuan Chuang
Cancer cells exhibit specific physiological differences compared to normal cells. Most surface membranes of cancer cells are characterized by high expression of given protein receptors, such as albumin, transferrin, and growth factors that are also present in the plasma of patients themselves, but are lacking on the surface of normal cells. These distinct features between cancer and normal cells can serve as a niche for developing specific treatment strategies. Near-infrared (NIR)-light-triggered therapy platforms are an interesting novel avenue for use in clinical nanomedicine...
July 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28720518/nanoparticle-based-hyperthermia-a-local-treatment-modulating-the-tumor-extracellular-matrix
#7
Jelena Kolosnjaj-Tabi, Iris Marangon, Alba Nicolas-Boluda, Amanda Brun, Florence Gazeau
The structural complexity and physical properties of the tumor microenvironment negatively affect the penetration and efficiency of conventional anticancer drugs. While previously underestimated, the tumor microenvironment now becomes a potential target for cancer treatment. This microenvironment can be modulated either systemically by pharmacological means, or locally, through physical effects mediated by certain nanoparticles. Some of them, such as magnetic, plasmonic or carbon-based nanoparticles, can generate heat on demand in a spatially and temporally controlled manner...
July 15, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28715967/hyperthermia-enhanced-targeted-drug-delivery-using-magnetic-resonance-guided-focussed-ultrasound-a-pre-clinical-study-in-a-genetic-model-of-pancreatic-cancer
#8
Navid Farr, Yak-Nam Wang, Samantha D'Andrea, Frank Starr, Ari Partanen, Kayla M Gravelle, Jeannine S McCune, Linda J Risler, Stella G Whang, Amy Chang, Sunil R Hingorani, Donghoon Lee, Joo Ha Hwang
PURPOSE: The lack of effective treatment options for pancreatic cancer has led to a 5-year survival rate of just 8%. Here, we evaluate the ability to enhance targeted drug delivery using mild hyperthermia in combination with the systemic administration of a low-temperature sensitive liposomal formulation of doxorubicin (LTSL-Dox) using a relevant model for pancreas cancer. MATERIALS AND METHODS: Experiments were performed in a genetically engineered mouse model of pancreatic cancer (KPC mice: LSL-Kras(G12D/+); LSL-Trp53(R172H/+); Pdx-1-Cre)...
July 17, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28715397/magnetic-and-thermal-sensitive-poly-n-isopropylacrylamide-based-microgels-for-magnetically-triggered-controlled-release
#9
Chih-Yu Kuo, Ting-Yu Liu, Kuan-Syun Wang, Andri Hardiansyah, Yen-Ting Lin, Hsueh-Yung Chen, Wen-Yen Chiu
Magnetically and thermally sensitive poly(N-isopropylacrylamide) (PNIPAAm)/Fe3O4-NH2 microgels with the encapsulated anti-cancer drug curcumin (Cur) were designed and fabricated for magnetically triggered release. PNIPAAm-based magnetic microgels with a spherical structure were produced via a temperature-induced emulsion followed with physical-crosslinking by mixing PNIPAAm, polyethylenimine (PEI), and Fe3O4-NH2 magnetic nanoparticles. Because of their dispersity, the Fe3O4-NH2 nanoparticles were embedded inside the polymer matrix...
July 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28713771/integrating-hyperthermia-into-modern-radiation-oncology-what-evidence-is-necessary
#10
REVIEW
Jan C Peeken, Peter Vaupel, Stephanie E Combs
Hyperthermia (HT) is one of the hot topics that have been discussed over decades. However, it never made its way into primetime. The basic biological rationale of heat to enhance the effect of radiation, chemotherapeutic agents, and immunotherapy is evident. Preclinical work has confirmed this effect. HT may trigger changes in perfusion and oxygenation as well as inhibition of DNA repair mechanisms. Moreover, there is evidence for immune stimulation and the induction of systemic immune responses. Despite the increasing number of solid clinical studies, only few centers have included this adjuvant treatment into their repertoire...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28693270/hyperthermia-and-radiation-reduce-the-toxic-side-effects-of-bufadienolides-for-cancer-therapy
#11
Heba Emam, Alaa Refaat, Paras Jawaid, Mati Ur Rehman, Peng Li, Qing-Li Zhao, Takashi Kondo
Bufadienolides are constituents of the traditional Chinese medicine Chan Su and are found in toad venom. Cardiovascular side-effects are one of the limiting factors towards developing bufadienolides as chemotherapeutic agents. Thus, in the present study, low doses of bufalin and cinobufotalin, prominent members of the bufadienolides, were investigated for their cytotoxic activity in combination with hyperthermia (HT) or radiation (Rad) therapy. In addition, the underlying mechanism involved was investigated...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693137/treatment-outcome-analysis-of-chemotherapy-combined-with-modulated-electro-hyperthermia-compared-with-chemotherapy-alone-for-recurrent-cervical-cancer-following-irradiation
#12
Sun Young Lee, Na Ri Lee, Dong-Hyu Cho, Jung Soo Kim
The survival of patients with recurrent cervical cancer following irradiation remains poor. Chemotherapy combined with hyperthermia has been demonstrated to improve the response rate. The present study was performed to evaluate the effect of modulated electro-hyperthermia combined with conventional chemotherapy compared with chemotherapy alone on recurrent cervical cancer previously treated with irradiation. A total of 20 patients were treated with chemotherapy alone, and 18 were treated with chemotherapy combined with modulated electro-hyperthermia...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28685676/recent-advances-in-superparamagnetic-iron-oxide-based-nanoprobes-as-multifunctional-theranostic-agents-for-breast-cancer-imaging-and-therapy
#13
Jianjun Zheng, Wenzhi Ren, Tianxiang Chen, Jin Yinhua, Aijing Li, Kun Yan, Yijiao Wu, Aiguo Wu
Breast cancer accounts for nearly one in three cancers, and it is the most common cancer diagnosed among women. The death rate of breast cancer is estimated to 14%. Hence, accurate diagnosis in early stage and effective treatment in any stage are critical for the survival of breast cancer. Mammogram has been the most common technique administered to detect breast cancer. However, the radiation dose from mammogram is harmful to patients. Fortunately, magnetic resonance imaging (MRI) can diagnose breast cancer without any radiation dose, and enhanced MRI can make earlier and differential diagnosis...
July 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28684911/photothermal-therapy-of-melanoma-tumor-using-multiwalled-carbon-nanotubes
#14
Zahra Sobhani, Mohammad Ali Behnam, Farzin Emami, Amirreza Dehghanian, Iman Jamhiri
Photothermal therapy (PTT) is a therapeutic method in which photon energy is transformed into heat rapidly via different operations to extirpate cancer. Nanoparticles, such as carbon nanotubes (CNTs) have exceptional optical absorbance in visible and near infrared spectra. Therefore, they could be a good converter to induce hyperthermia in PTT technique. In our study, for improving the dispersibility of multiwalled CNTs in water, the CNTs were oxidized (O-CNTs) and then polyethylene glycol (PEG) was used for wrapping the surface of nanotubes...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28684680/bevacizumab-based-chemotherapy-combined-with-regional-deep-capacitive-hyperthermia-in-metastatic-cancer-patients-a-pilot-study
#15
Girolamo Ranieri, Cristina Ferrari, Alessandra Di Palo, Ilaria Marech, Mariangela Porcelli, Gianmarco Falagario, Fabiana Ritrovato, Luigi Ramunni, Margherita Fanelli, Giuseppe Rubini, Cosmo Damiano Gadaleta
As an angiogenesis inhibitor, bevacizumab has been investigated in combination with different chemotherapeutic agents, achieving an established role for metastatic cancer treatment. However, potential synergic anti-angiogenic effects of hyperthermia have not tested to date in literature. The aim of our study was to analyze efficacy, safety, and survival of anti-angiogenic-based chemotherapy associated to regional deep capacitive hyperthermia (HT) in metastatic cancer patients. Twenty-three patients with metastatic colorectal (n = 16), ovarian (n = 5), and breast (n = 2) cancer were treated with HT in addition to a standard bevacizumab-based chemotherapy regimen...
July 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28683723/case-report-anaesthetic-management-of-radical-gastrectomy-for-gastric-cancer-associated-with-anti-n-methyl-d-aspartate-receptor-encephalitis
#16
Lei Ding, Hongyu Tan, Ziyu Li, Jiafu Ji, Xuejun Song
BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a rare neurological disorder that is caused by the production of antibodies against NMDARs. As many anaesthetic drugs interact with NMDARs and may worsen the disease and because the disease poses risks, such as cardiovascular events, hyperthermia and respiratory insufficiency, while under anaesthesia, administering anaesthesia to patients with this disorder is clinically challenging. CASE PRESENTATION: A 55-year-old man with gastric cancer associated with anti-NMDAR encephalitis who was diagnosed 8 months prior was admitted to Peking University Cancer Hospital for tumour resection...
July 6, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28679349/relationships-between-thermal-dose-parameters-and-the-efficacy-of-definitive-chemoradiotherapy-plus-regional-hyperthermia-in-the-treatment-of-locally-advanced-cervical-cancer-data-from-a-multicenter-randomized-clinical-trial
#17
Takayuki Ohguri, Yoko Harima, Hajime Imada, Hideyuki Sakurai, Tatsuya Ohno, Yoshiyuki Hiraki, Koh Tuji, Masahiro Tanaka, Hiromi Terashima
PURPOSE: To evaluate the contribution of the thermal dose parameters during regional hyperthermia (HT) treatment to the clinical outcomes in patients with cervical carcinoma (CC) who received chemoradiotherapy (CRT) plus HT. MATERIALS AND METHODS: Data from a multicenter randomized clinical trial of concurrent CRT+HT vs. CRT alone were used to evaluate the efficacy and safety of this combination therapy in the CC patients. The intrarectal temperatures of patients undergoing HT were recorded...
July 5, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28679178/effectivity-of-intravescical-thermo-chemotherapy-prophylaxis-for-patients-with-high-recurrence-and-progression-risk-for-non-muscle-invasive-bladder-cancer
#18
Ali Serdar Gözen, Paolo Umari, Walter Scheitlin, Fuat Ernis Su, Yigit Akin, Jens Rassweiler
Background&Aim: High grade non-muscle invasive bladder cancer (NMIBC) is common in urological practice. Most of these cancers are or become refractory to intravesical immunotherapy and chemotherapy. Here we evaluated the efficacy of combined local bladder hyperthermia and intravesical mitomycin-C (MMC) instillation in patients with high-risk recurrent NMIBC. MATERIALS AND METHODS: Between February 2014 and December 2015, 18 patients with high risk NMIBC were enrolled. Patients were treated in an outpatient basis with 6 weekly induction sessions followed by monthly maintenance sessions with intravesical MMC in local hyperthermia with bladder wall thermo-chemotherapy (BWT) system (PelvixTT system, Elmedical Ltd...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28675807/autophagy-inhibition-enabled-efficient-photothermal-therapy-at-a-mild-temperature
#19
Zhengjie Zhou, Yang Yan, Kewen Hu, Yuan Zou, Yiwen Li, Rui Ma, Qiang Zhang, Yiyun Cheng
The heterogeneously-distributed hyperthermia in nanomaterial-mediated photothermal therapy commonly results in incomplete tumor eradication and serious damage of health tissue. Here, we found autophagy was activated in cancer cells underwent photothermal therapy and the inhibition of autophagy significantly enhanced the efficacy of photothermal killing of cancer cells. A formulation of chloroquine-loaded polydopamine nanoparticles was developed for sensitized photothermal cancer therapy, and the in vitro and in vivo study demonstrated that inhibition of autophagy remarkably augmented the efficacy of photothermal therapy, leading to efficient tumor suppression at a mild temperature...
June 27, 2017: Biomaterials
https://www.readbyqxmd.com/read/28663855/simulation-of-nanoparticle-mediated-near-infrared-thermal-therapy-using-gate
#20
Vesna Cuplov, Frédéric Pain, Sébastien Jan
Application of nanotechnology for biomedicine in cancer therapy allows for direct delivery of anticancer agents to tumors. An example of such therapies is the nanoparticle-mediated near-infrared hyperthermia treatment. In order to investigate the influence of nanoparticle properties on the spatial distribution of heat in the tumor and healthy tissues, accurate simulations are required. The Geant4 Application for Emission Tomography (GATE) open-source simulation platform, based on the Geant4 toolkit, is widely used by the research community involved in molecular imaging, radiotherapy and optical imaging...
March 1, 2017: Biomedical Optics Express
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