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https://www.readbyqxmd.com/read/28626897/ultrastable-near-infrared-conjugated-polymer-nanoparticles-for-dually-photoactive-tumor-inhibition
#1
Tao Yang, Ling Liu, Yibin Deng, Zhengqing Guo, Guobing Zhang, Zhishen Ge, Hengte Ke, Huabing Chen
It is highly desired that satisfactory photoactive agents with ideal photophysical characteristics are explored for potent cancer phototherapeutics. Herein, bifunctional nanoparticles of low-bandgap donor-acceptor (D-A)-type conjugated-polymer nanoparticles (CP-NPs) are developed to afford a highly efficient singlet-to-triplet transition and photothermal conversion for near-infrared (NIR) light-induced photodynamic (PDT)/photothermal (PTT) treatment. CP-NPs display remarkable NIR absorption with the peak at 782 nm, and perfect resistance to photobleaching...
June 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28625829/combinatorial-immunotherapy-and-nanoparticle-mediated-hyperthermia
#2
Austin J Moy, James W Tunnell
Immune checkpoint therapy has become the first widely adopted immunotherapy for patients with late stage malignant melanoma, with potential for a wide range of cancers. While some patients can experience long term disease remission, this is limited only to a subset of patients and tumor types. The path forward to expand this therapy to more patients and tumor types is currently thought to be combinatorial treatments, the combination of immunotherapy with other treatments. In this review, the combinatorial approach of immune checkpoint therapy combined with nanoparticle-assisted localized hyperthermia is discussed, starting with an overview of the different nanoparticle hyperthermia approaches in development, an overview of the state of immune checkpoint therapy, recent reports of immune checkpoint therapy and nanoparticle-assisted hyperthermia in a combinatorial approach, and finally a discussion of future research topics and areas to be explored in this new combinatorial approach to cancer treatment...
June 15, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28624871/synthesis-and-application-of-magnetite-dextran-spermine-nanoparticles-in-breast-cancer-hyperthermia
#3
Reza Avazzadeh, Ebrahim Vasheghani-Farahani, Masoud Soleimani, Saeid Amanpour, Mohsen Sadeghi
Cancer treatment has been very challenging in recent decades. One of the most promising cancer treatment methods is hyperthermia, which increases the tumor temperature (41-45 °C). Magnetic nanoparticles have been widely used for selective targeting of cancer cells. In the present study, magnetic dextran-spermine nanoparticles, conjugated with Anti-HER2 antibody to target breast cancer cells were developed. The magnetic dextran-spermine nanoparticles (DMNPs) were prepared by ionic gelation, followed by conjugation of antibody to them using EDC-NHS method...
June 17, 2017: Progress in biomaterials
https://www.readbyqxmd.com/read/28610455/non-fourier-thermal-transport-induced-structural-hierarchy-and-damage-to-collagen-ultrastructure-subjected-to-laser-irradiation
#4
Nilamani Sahoo, Arunn Narasimhan, Purbarun Dhar, Sarit Kumar Das
Comprehending the mechanism of thermal transport through biological tissues is an important factor for optimal ablation of cancerous tissues and minimising collateral tissue damage. The present study reports detailed mapping of the rise in internal temperature within the tissue mimics due to NIR (1064 nm) laser irradiation, both for bare mimics and with gold nanostructures infused. Gold nanostructures such as mesoflowers and nano spheres have been synthesized and used as photothermal converters to enhance the temperature rise, resulting in achieving the desired degradation of malignant tissue in targeted region...
June 13, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28605946/design-and-characterization-of-a-phased-antenna-array-for-intact-breast-hyperthermia
#5
Sergio Curto, Aleix Garcia-Miquel, Minyoung Suh, Neus Vidal, Jose M Lopez-Villegas, Punit Prakash
PURPOSE: Currently available hyperthermia technology is not well suited to treating cancer malignancies in the intact breast. This study investigates a microwave applicator incorporating multiple patch antennas, with the goal of facilitating controllable power deposition profiles for treating lesions at diverse locations within the intact breast. MATERIALS AND METHODS: A 3D-computational model was implemented to assess power deposition profiles with 915 MHz applicators incorporating a hemispheric groundplane and configurations of 2, 4, 8, 12, 16 and 20 antennas...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28595072/zinc-phthalocyanines-attached-to-gold-nanorods-for-simultaneous-hyperthermic-and-photodynamic-therapies-against-melanoma-in-vitro
#6
L F Freitas, M R Hamblin, F Anzengruber, J R Perussi, A O Ribeiro, V C A Martins, A M G Plepis
Studies indicate that hyperthermic therapy using gold nanorods and photodynamic activity with many photosensitizers can present a synergistic effect, and offer a great therapeutic potential, although more investigation needs to be performed before such approach could be implemented. We proposed to investigate the effect of the attachment of phthalocyanines on the surface of gold nanorods (well-characterized devices for hyperthermia generation) for the elimination of melanoma, one of the most important skin cancers due to its high lethality...
May 30, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28588736/treatment-outcomes-of-concurrent-hyperthermia-and-chemoradiotherapy-for-pancreatic-cancer-insights-into-the-significance-of-hyperthermia-treatment
#7
Toshiya Maebayashi, Naoya Ishibashi, Takuya Aizawa, Masakuni Sakaguchi, Tsutomu Sato, Jiro Kawamori, Yoshiaki Tanaka
Patients with locally advanced unresectable pancreatic cancer (LAUPC) have a poor prognosis. In addition their quality of life impaired by cancer pain and biliary tract infections. Therefore, multimodality therapy and selection of optimal treatment methods are essential for achieving prolonged survival. The present study investigated the significance of using hyperthermia concurrently with multimodality therapy to improve treatment outcomes in patients with LAUPC. In total, 13 patients receiving concurrent hyperthermia and chemoradiotherapy (HCR) or chemoradiotherapy (CR) alone for LAUPC between 2002 and 2013 were analyzed retrospectively...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28588670/anticancer-effects-of-%C3%AE-elemene-with-hyperthermia-in-lung-cancer-cells
#8
Zhibing Wu, Ting Wang, Yanmei Zhang, Zhishuang Zheng, Shuhuan Yu, Saisai Jing, Sumei Chen, Hao Jiang, Shenglin Ma
β-elemene is a novel, plant-derived anticancer drug, which has been used to target multiple solid tumor types. Hyperthermia is an adjuvant therapeutic modality to treat cancer. However, the underlying mechanisms associated with the efficacy of these two treatments are largely unknown. The aim of the present study was to evaluate the effects of β-elemene combined with hyperthermia in lung cancer cell lines. An MTT assay was used to determine cell viability. The cell cycle and apoptosis were analyzed using flow cytometry...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28585348/synthesis-of-magnetic-nanoparticle-ansamitocin-conjugates-inductive-heating-leads-to-decreased-cell-proliferation-in-vitro-and-attenuation-of-tumour-growth-in-vivo
#9
Andreas Kirschning, Liang Liang Wang, Katja Seidel, Michael Ott, Asha Balakrishnan, Ronja Komoll, Christina Janko, Christoph Alexiou
Conjugates based on nanostructured, superparamagnetic particles, a thermolabile linker and a cytotoxic maytansinoid were developed to serve as a model for tumour selective drug delivery and release. It combines chemo- with thermal therapy. The linker-modified toxin was prepared by a combination of biotechnology and semisynthesis.Drug release was achieved by hyperthermia through an external oscillating electromagnetic field that induces heat inside the particles. Efficacy of this release concept was demonstrated both for cancer cell proliferation in vitro, and for tumour growth in vivo, in a xenograft mouse model...
June 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28580979/design-of-tpgs-functionalized-cu3bis3-nanocrystals-with-strong-absorption-in-the-second-near-infrared-window-for-radiation-therapy-enhancement
#10
Jiangfeng Du, Xiaopeng Zheng, Yuan Yong, Jie Yu, Xinghua Dong, Chenyang Zhang, Ruyi Zhou, Bai Li, Liang Yan, Chunying Chen, Zhanjun Gu, Yuliang Zhao
Integrating radiation therapy with high-depth photothermal therapy in the second near-infrared (NIR) window is highly required for efficient treatment of deep-seated tumor cells. Here, we constructed a multifunctional nano-theranostic with bimetallic chalcogenide nanocrystals (NCs) functionalized with amphiphilic d-α-tocopherol polyethylene glycol 1000 succinate (TPGS-Cu3BiS3). Benefiting from the strong absorbance of both X-ray and NIR light in the second NIR window, TPGS-Cu3BiS3 CNs can not only deposit more radiation dose to trigger enhanced radiation damage in vivo, but also conduct photo-induced hyperthermia for thermal ablation in the second NIR window and effective improvement of tumor oxygenation to overcome the hypoxia-associated radio-resistance of tumors...
June 5, 2017: Nanoscale
https://www.readbyqxmd.com/read/28580312/the-role-of-radiofrequency-hyperthermia-in-the-radiosensitization-of-a-human-prostate-cancer-cell-line
#11
Azam Janati Esfahani, Seied Rabi Mahdavi, Mohammad Bagher Shiran, Samideh Khoei
OBJECTIVE: This study evaluated enhanced induced DNA damages and apoptosis of a spheroid culture of DU145 prostate cancer cells treated by a combination of radiofrequency hyperthermia (RF HT) with radiation treatment (RT) from an external radiotherapy machine compared to RT alone. MATERIALS AND METHODS: In this experimental study, DU145 cells were cultured as spheroids until they reached 300 µm in diameter. We exposed these cultures to either: RF HT for 90 minutes at 43˚C originated from a Celsius TCS system, RF HT followed by RT at doses of 2 Gy or 4 Gy (15 MV energy) with 15-minute interval, or RT alone at the above mentioned doses...
2017: Cell Journal
https://www.readbyqxmd.com/read/28580311/enhanced-dna-damages-of-human-prostate-cancer-cells-induced-by-radiofrequency-capacitive-hyperthermia-pre-and-post-x-rays-6-mv-versus-15-mv
#12
Seied Rabi Mahdavi, Azam Janati Esfahani, Mohammad Bagher Shiran, Samideh Khoei, Nader Estiri
OBJECTIVE: This study aimed to determine the effect of 13.56 MHz radiofrequency (RF) capacitive hyperthermia (HT) on radiosensivity of human prostate cancer cells pre and post X-ray radiation treatment (RT). MATERIALS AND METHODS: In this experimental study, the human prostate cancer cell line DU145 was cultured as 300 µm diameter spheroids. We divided the spheroids into group I: control, group II: HT at 43˚C for 30 minutes (HT), group III: 4 Gy irradiation with 6 MV X-ray [RT (6 MV)], group IV: 4 Gy irradiation with 15 MV X-ray [RT (15 MV)], group V: HT+RT (6 MV), group VI: HT+RT (15 MV), group VII: RT (6 MV)+HT, and group VIII: RT (15 MV)+HT...
2017: Cell Journal
https://www.readbyqxmd.com/read/28576066/designing-of-macroporous-magnetic-bioscaffold-based-on-functionalized-methacrylate-network-covered-by-hydroxyapatites-and-doped-with-nano-mgfe2o4-for-potential-cancer-hyperthermia-therapy
#13
Łukasz John, Mateusz Janeta, Sławomir Szafert
In this paper, we report on synthesis and characterization of three-dimensional biocomposite based on a polymerized 3-(trimethoxysilyl)propyl methacrylate/ethylene glycol dimethacrylate (pTMSPMA/pEGDMA) framework. The resulting composite was doped with Ca(2+) and PO4(3-) or decorated by hydroxyapatite (HA) and carbonate hydroxyapatite (CHA) to aid potential bone fixation and the in vitro bioactivity was evaluated. During the construction of the macroporous scaffold, the size and shape of pores were modified depending on the type of porogens which was applied (commercially available sugar, NaCl, or NH4Cl)...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28576058/colloidal-properties-and-in-vitro-evaluation-of-hydroxy-ethyl-cellulose-coated-iron-oxide-particles-for-targeted-drug-delivery
#14
Maide Gökçe Bekaroğlu, Yavuz İşçi, Sevim İşçi
In this study, superparamagnetic iron oxide (Fe3O4) nanoparticles were prepared for the targeted drug delivery applications by controlling the colloidal properties with a cellulosic polymer that is Hydroxy ethyl cellulose (HEC). Fe3O4 particles were treated with HEC in a variable range of polymer concentration. Rheological, electrokinetic, magnetorheological and morphological properties of the dispersions were investigated to have stable and fully covered surfaces of Fe3O4 particles by coating with HEC and obtaining non-toxic biocompatible multifunctional magnetic particles...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28565928/iron-oxide-magnetic-nanoparticles-as-antimicrobials-for-therapeutics
#15
Lucas de Alcântara Sica de Toledo, Hélen Cássia Rosseto, Marcos Luciano Bruschi
The use of iron oxide magnetic nanoparticles (IMNP) in medical and pharmaceutical areas dates to the beginning of the 1970s, as carriers. Some other uses to these nanoparticles are in vitro separation, magnetic resonance imaging and drug targeting agent. Many preparations containing IMNP have been described and used in drug delivery, hyperthermia, in vitro separation, tissue repair, cellular therapy, for magnetic separation, magnetic resonance imaging, as spoilers for magnetic resonance spectroscopy, and more recently as sensors for metabolites and other biomolecules...
June 21, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28558940/hyperthermia-enhances-bortezomib-induced-apoptosis-in-human-white-blood-cancer-cells
#16
Timur Saliev, Loreto B Feril, Dinara Begimbetova, Dinara Baiskhanova, Anton Klodzinskyi, Xeniya Bobrova, Rassulbek Aipov, Tolkyn Baltabayeva, Katsuro Tachibana
At present, the current therapeutic strategy for apoptosis induction mainly relies on the administration of pharmacological apoptotic modulators. Apart from that, apoptosis can be induced by various external stimuli such as hyperthermia, ionizing radiation, and electric fields. Despite advantages, both physical and pharmacological approaches bear some limitations as well. The rationale of this study was to overcome the limitations by combining hyperthermia and apoptotic modulator 'bortezomib' (Velcade). Two types of human blood cancer cell lines were utilized: human leukemic monocyte lymphoma cell U937 line and peripheral blood mononuclear cells (PMBCs) derived from the patient diagnosed with acute myeloid leukemia...
July 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28558937/numerical-simulation-of-time-fractional-dual-phase-lag-model-of-heat-transfer-within-skin-tissue-during-thermal-therapy
#17
Dinesh Kumar, K N Rai
In this paper, we investigated the thermal behavior in living biological tissues using time fractional dual-phase-lag bioheat transfer (DPLBHT) model subjected to Dirichelt boundary condition in presence of metabolic and electromagnetic heat sources during thermal therapy. We solved this bioheat transfer model using finite element Legendre wavelet Galerkin method (FELWGM) with help of block pulse function in sense of Caputo fractional order derivative. We compared the obtained results from FELWGM and exact method in a specific case, and found a high accuracy...
July 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28557569/the-global-end-diastolic-volume-gedv-could-be-more-appropiate-to-fluid-management-than-central-venous-pressure-cvp-during-closed-hyperthermic-intrabdominal-chemotherapy-with-co2-circulation
#18
Francisco Javier Redondo, David Padilla, Pedro Villarejo, Victor Baladron, Patricia Faba, Sergio Sánchez, José Ramón Muñoz-Rodríguez, Natalia Bejarano
BACKGROUND: Closed hyperthermic intraperitoneal chemotherapy (HIPEC) may increase abdominal pressure and effects of hemodynamic changes due to maintenance hyperthermia. Our aim was to analyze the safety and effectiveness of our closed technique with CO2 circulation in management fluid status and hemodynamic parameters by means of cardiac preload control measured by Global End Diastolic Values (GEDV) and a gas exchanger. MATERIAL AND METHODS: A Pilot Clinical Study that included 18 advanced ovarian cancer patients undergoing citoreductive surgery and HIPEC...
May 30, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28553112/ionp-doped-nanoparticles-for-highly-effective-nir-controlled-drug-release-and-combination-tumor-therapy
#19
Xudong Fu, Xinjun Wang, Shaolong Zhou, Yanyan Zhang
Despite advances in controlled drug delivery, drug delivery systems (DDSs) with controlled activated drug release and high spatial and temporal resolution are still required. Theranostic nanomedicine is capable of diagnosis, therapy, and monitoring the delivery and distribution of drug molecules and has received growing interest. In this study, a near-infrared light-controlled "off-on" DDS with magnetic resonance imaging and magnetic targeting properties was developed using a hybrid nanoplatform (carbon nanotubes [CNTs]-iron oxide nanoparticle)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28549003/noninvasive-thermometry-in-high-intensity-focused-ultrasound-ablation
#20
Yufeng Zhou
High-intensity focused ultrasound (HIFU) is emerging as an effective and promising treatment modality for the formation of coagulative necrosis inside the cancer/tumor noninvasively. To guarantee the efficacy and efficiency of HIFU ablation, the temperature field and consequent thermal dose should be monitored accurately in a high temporal and spatial resolution in real time. However, because of the significant variations of the tissue properties and deep penetration of HIFU beam, especially in the abdominal application, noninvasive thermometry is a very challenging topic, which may hamper the wide acceptance of HIFU by physicians worldwide...
May 25, 2017: Ultrasound Quarterly
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