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https://www.readbyqxmd.com/read/28106206/moo3-x-quantum-dots-for-photoacoustic-imaging-guided-photothermal-photodynamic-cancer-treatment
#1
Dandan Ding, Wei Guo, Chongshen Guo, Jianzhe Sun, Nannan Zheng, Fei Wang, Mei Yan, Shaoqin Liu
A theranostic system of image-guided phototherapy is considered as a potential technique for cancer treatment because of the ability to integrate diagnostics and therapies together, thus enhancing accuracy and visualization during the treatment. In this work, we realized photoacoustic (PA) imaging-guided photothermal (PT)/photodynamic (PD) combined cancer treatment just via a single material, MoO3-x quantum dots (QDs). Due to their strong NIR harvesting ability, MoO3-x QDs can convert incident light into hyperthermia and sensitize the formation of singlet oxygen synchronously as evidenced by in vitro assay, hence, they can behave as both PT and PD agents effectively and act as a "dual-punch" to cancer cells...
January 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28104923/unique-heating-curves-generated-by-radiofrequency-electric-field-interactions-with-semi-aqueous-solutions
#2
Nadia C Lara, Asad A Haider, Lon J Wilson, Steven A Curley, Stuart J Corr
Aqueous and nanoparticle-based solutions have been reported to heat when exposed to an alternating radiofrequency (RF) electric-field. Although the theoretical models have been developed to accurately model such a behavior given the solution composition as well as the geometrical constraints of the sample holder, these models have not been investigated across a wide-range of solutions where the dielectric properties differ, especially with regard to the real permittivity. In this work, we investigate the RF heating properties of non-aqueous solutions composed of ethanol, propylene glycol, and glycine betaine with and without varying amounts of NaCl and LiCl...
January 2, 2017: Applied Physics Letters
https://www.readbyqxmd.com/read/28100096/targeting-therapy-resistant-cancer-stem-cells-by-hyperthermia
#3
A L Oei, L E M Vriend, P M Krawczyk, M R Horsman, N A P Franken, J Crezee
Eradication of all malignant cells is the ultimate but challenging goal of anti-cancer treatment; most traditional clinically-available approaches fail because there are cells in a tumor that either escape therapy or become therapy-resistant. A subpopulation of cancer cells, the cancer stem cells (CSCs), is considered to be of particular significance for tumor initiation, progression and metastasis. CSCs are considered in particular to be therapy-resistant and may drive disease recurrence, which positions CSCs in the focus of anti-cancer research, but successful CSC-targeting therapies are limited...
January 19, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28093325/gold-nanostar-polymer-hybrids-for-sirna-delivery-polymer-design-towards-colloidal-stability-and-in-vitro-studies-on-breast-cancer-cells
#4
Carla Sardo, Barbara Bassi, Emanuela F Craparo, Cinzia Scialabba, Elisa Cabrini, Giacomo Dacarro, Agnese D'Agostino, Angelo Taglietti, Gaetano Giammona, Piersandro Pallavicini, Gennara Cavallaro
To overcome the low bioavailability of siRNA (small interfering RNA) and to improve their transfection efficiency, the use of non-viral delivery carriers is today a feasible approach to transform the discovery of these incredibly potent and versatile drugs into clinical practice. Polymer-modified gold nanoconstructs (AuNCs) are currently viewed as efficient and safe intracellular delivery carriers for siRNA, as they have the possibility to conjugate the ability to stably entrap and deliver siRNAs inside cells with the advantages of gold nanoparticles, which can act as theranostic agents and radiotherapy enhancers through laser-induced hyperthermia...
January 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28093005/cardiac-and-respiratory-effects-of-deep-regional-hyperthermia-using-an-8-mhz-radiofrequency-capacitive-device-on-patients-with-cancer
#5
Rieko Izukura, Hajime Imada, Nobuko Hashiguchi, Hiroyuki Sawatari, Takayuki Ohguri, Mami Miyazono, Shin Ohta, Chizuko Takakura, Keiko Yamasaki, Chie Magota, Kanae Fujita, Hiromi Kuroda, Hideki Hirata, Tomoko Ohkusa, Akiko Chishaki
PURPOSE: Hyperthermia (HT), an adjuvant therapy for variable cancers, may cause physiological changes in the patients, which may lead to cardiovascular problems. Among various HT treatments, the physiological effects of deep regional HT are still unclear. We examined the physiological alterations throughout deep regional HT to improve the HT safety. MATERIALS AND METHODS: Thirty-one patients (age: 61±12 years) with cancer received HT in the thoracic or upper abdominal regions using an 8-MHz radiofrequency-capacitive-device for 50 min...
January 16, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28088668/near-infrared-light-triggered-drug-delivery-system-for-higher-efficacy-of-combined-chemo-photothermal-treatment
#6
Yi Chen, Haohuan Li, Yueyang Deng, Haifeng Sun, Xue Ke, Tianyuan Ci
: The combination of chemotherapy and photothermal therapy is a promising strategy for cancer treatment. In the present study, indocyanine green (ICG), a widely used near-infrared (NIR) dye in photothermal therapy, and chemotherapeutic drug-doxorubicin (DOX) were loaded within the nanoparticles of novel designed arylboronic ester and cholesterol modified hyaluronic acid (PPE-Chol1-HA), denoted as PCH-DI. We take advantage of reactive oxygen species (ROS) production capability of ICG and ROS-sensitivity of arylboronic ester to realize controllable drug release...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28078950/magnetic-nanoparticles-based-drug-and-gene-delivery-systems-for-the-treatment-of-pulmonary-diseases
#7
Ibrahim M El-Sherbiny, Nancy M Elbaz, Mohammed Sedki, Abdulaziz Elgammal, Magdi H Yacoub
Magnetic nanoparticles (MNPs) have gained much attention due to their unique properties such as biocompatibility and biodegradability as well as magnetic and heat-medicated characteristics. Due to these inherent properties, MNPs have been widely used in various biomedical applications including targeted drug delivery and hyperthermia-based therapy. Hyperthermia is a promising approach for the thermal activation therapy of several diseases, including pulmonary diseases. Additionally, due to their large loading capacity and controlled release ability, several MNP-based drug delivery systems have been emerged for treatment of cystic fibrosis and lung cancer...
January 12, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28072430/measurement-of-thermal-conductivity-of-porcine-liver-in-the-temperature-range-of-cryotherapy-and-hyperthermia-250-315k-by-a-thermal-sensor-made-of-a-micron-scale-enameled-copper-wire
#8
Z D Jiang, G Zhao, G R Lu
:   BACKGROUND: Cryotherapy and hyperthermia are effective treatments for several diseases, especially for liver cancers. Thermal conductivity is a significant thermal property for the prediction and guidance of surgical procedure. However, the thermal conductivities of organs and tissues, especially over the temperature range of both cryotherapy and hyperthermia are scarce. OBJECTIVE: To provide comprehensive thermal conductivity of liver for both cryotherapy and hyperthermia...
November 2016: Cryo Letters
https://www.readbyqxmd.com/read/28069201/pulsed-wave-low-dose-ultrasound-hyperthermia-selectively-enhances-nanodrug-delivery-and-improves-antitumor-efficacy-for-brain-metastasis-of-breast-cancer
#9
Sheng-Kai Wu, Chi-Feng Chiang, Yu-Hone Hsu, Houng-Chi Liou, Wen-Mei Fu, Win-Li Lin
The clinical application of chemotherapeutics for brain tumors remains a challenge due to limitation of blood-brain barrier/blood-tumor barrier (BBB/BTB). In this study, we investigated the effects of low-dose focused ultrasound hyperthermia (UH) on the delivery and therapeutic efficacy of pegylated liposomal doxorubicin (PLD) for brain metastasis of breast cancer. Murine breast cancer cells (4T1-luc2) expressing firefly luciferase were implanted into mouse striatum as a brain tumor model. The mice were intravenously injected with PLD with/without transcranial pulsed-wave/continuous-wave UH (pUH/cUH) treatment on day-6 after tumor implantation...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28056401/toxicity-evaluation-of-magnetic-hyperthermia-induced-by-remote-actuation-of-magnetic-nanoparticles-in-3d-micrometastasic-tumor-tissue-analogs-for-triple-negative-breast-cancer
#10
Nathanael A Stocke, Pallavi Sethi, Amar Jyoti, Ryan Chan, Susanne M Arnold, J Zach Hilt, Meenakshi Upreti
Magnetic hyperthermia as a treatment modality is acquiring increased recognition for loco-regional therapy of primary and metastatic lung malignancies by pulmonary delivery of magnetic nanoparticles (MNP). The unique characteristic of magnetic nanoparticles to induce localized hyperthermia in the presence of an alternating magnetic field (AMF) allows for preferential killing of cells at the tumor site. In this study we demonstrate the effect of hyperthermia induced by low and high dose of MNP under the influence of an AMF using 3D tumor tissue analogs (TTA) representing the micrometastatic, perfusion independent stage of triple negative breast cancer (TNBC) that infiltrates the lungs...
December 23, 2016: Biomaterials
https://www.readbyqxmd.com/read/28054529/a-retrospective-analysis-of-patients-with-head-and-neck-cancer-treated-with-radiation-hyperthermia-and-cetuximab-a-brief-report-of-outcome
#11
Nagraj G Huilgol
PURPOSE: Advanced head and neck cancer continues to have a dismal outcome. Chemoradiation remains the current standard of care. Chemoradiation has not achieved the desired increase in survival in locally advanced head and neck cancer. This is a retrospective analysis of six patients treated with hyperthermia, radiation therapy, and cetuximab. We wished to determine if this combination treatment would further improve the outcome. MATERIALS AND METHODS: Six patients with squamous cell cancer of the head and neck region were treated with hyperthermia, cetuximab, and radiation therapy...
July 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28052042/a-printed-yagi-uda-antenna-for-application-in-magnetic-resonance-thermometry-guided-microwave-hyperthermia-applicators
#12
Margarethus Marius Paulides, R Mestrom, Ghassan Salim, Bedilu Adela, Wouter Numan, Tomas Drizdal, Desmond Yeo, Bart Smolders
Biological studies and clinical trials show that addition of hyperthermia stimulates conventional cancer treatment modalities and significantly improves treatment outcome. This supra-additive stimulation can be optimized by adaptive hyperthermia to counteract strong and dynamic thermoregulation. The only clinically proven method for the 3D non-invasive temperature monitoring required is by magnetic resonance (MR) temperature imaging, but the currently available set of MR compatible hyperthermia applicators lack the degree of heat control required...
January 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28048054/su-f-j-05-the-effect-of-air-pockets-in-the-urinary-bladder-during-bladder-hyperthermia-treatment
#13
G Schooneveldt, H P Kok, A Bakker, E D Geijsen, T M de Reijke, J Crezee
PURPOSE: Hyperthermia combined with Mitomycin C is used for the treatment of non-muscle invasive bladder cancer (NMIBC), using a phased array system of microwave antennas for bladder heating. Often some air is present in the bladder, which effectively blocks the microwave radiation, potentially preventing proper treatment of that part of the bladder. Air can be a relevant fraction of the bladder content and large air pockets are expected to have a noticeable influence on achieved temperatures...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046912/su-f-e-04-a-paris-system-based-implant-approach-to-hyperthermia-cancer-tumor-with-gold-seeds-and-ultrasound
#14
C Austerlitz, A Barros, I Gkigkitzis, I Haranas, D Zhu, D Campos
PURPOSE: To apply the Paris system-based implant for an uniform bio-heat distribution from implanted gold rods in tissue insonated with ultrasound. METHODS: Experiments with single-plane implants using parallel equidistant 1.018 ± 0.015 cm height and 0.136 ± 0.001 cm diameter 24-K gold rods) arranged in triangular and square shapes were performed in Mus Musculus white mice (medial dorsal region). The mice were anesthetized and gold rods were implanted by means of a trocar needle and the implanted region was insonated with a 4-cm diameter transducer oscillating with a nominal frequency of 1 MHz and power of about 75 W...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042085/sequential-hifu-heating-and-nanobubble-encapsulation-provide-efficient-drug-penetration-from-stealth-and-temperature-sensitive-liposomes-in-colon-cancer
#15
Joshua VanOsdol, Kalyani Ektate, Selvarani Ramasamy, Danny Maples, Willie Collins, Jerry Malayer, Ashish Ranjan
Mild hyperthermia generated using high intensity focused ultrasound (HIFU) and microbubbles (MBs) can improve tumor drug delivery from non-thermosensitive liposomes (NTSLs) and low temperature sensitive liposomes (LTSLs). However, MB and HIFU are limited by the half-life of the contrast agent and challenges in accurate control of large volume tumor hyperthermia for longer duration (>30min.). The objectives of this study were to: 1) synthesize and characterized long-circulating echogenic nanobubble encapsulated LTSLs (ELTSLs) and NTSLs (ENTSLs), 2) evaluate in vivo drug release following short duration (~20min each) HIFU treatments administered sequentially over an hour in a large volume of mouse xenograft colon tumor, and 3) determine the impact of the HIFU/nanobubble combination on intratumoral drug distribution...
December 30, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28029783/platinum-coated-gold-nanorods-efficient-reactive-oxygen-scavengers-that-prevent-oxidative-damage-toward-healthy-untreated-cells-during-plasmonic-photothermal-therapy
#16
Mena Aioub, Sajanlal R Panikkanvalappil, Mostafa A El-Sayed
As a minimally invasive therapeutic strategy, gold nanorod (AuNR)-based plasmonic photothermal therapy (PPT) has shown significant promise for the selective ablation of cancer cells. However, the heat stress experienced by cells during the PPT treatment produces significant amounts of reactive oxygen species (ROS), which could harm healthy, untreated tissue near the point of care by inducing irreversible damage to DNA, lipids, and proteins, potentially causing cellular dysfunction or mutation. In this study, we utilized biocompatible Pt-coated AuNRs (PtAuNRs) with different platinum shell thicknesses as an alternative to AuNRs often used for the treatment...
January 3, 2017: ACS Nano
https://www.readbyqxmd.com/read/28024357/controllable-co-release-following-near-infrared-light-induced-cleavage-of-iron-carbonyl-derivatized-prussian-blue-nanoparticles-for-co-assisted-synergistic-treatment
#17
Wei-Peng Li, Chia-Hao Su, Ling-Chuan Tsao, Chun-Ting Chang, Ya-Ping Hsu, Chen-Sheng Yeh
Carbon monoxide (CO) causes the dysfunction of mitochondria to induce the apoptosis of cancer cells giving a promising choice as an emerging treatment. The currently reported CO-based complexes still suffer from many limitations. Synthesis of CO-release carriers in the manner of on-demand control is highly anticipated. In this study, we present a near-infrared (NIR) light-responsive CO-delivery nanocarrier, a PEGylated iron carbonyl derivatized Prussian blue (PB) nanoparticle (NP). Taking the structural characteristic containing Fe(3+)-N≡C-Fe(2+) unit, the -CN(-) served as the active sites for the coordination of iron carbonyl, while the surface Fe sites chelated with the amine-functionalized polyethylene glycol (NH2-PEG6000-NH2) to yield PEGylated PB NPs carrying CO...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28009506/earthicle-the-design-of-a-conceptually-new-type-of-particle
#18
Vuk Uskoković, Sebastian Pernal, Victoria M Wu
The conception and the steps made in the design of a conceptually new type of composite particle, so-called "earthicle", are being described. This particle is meant to roughly mimic the layered structure of the Earth, having zerovalent iron core, silicate mantle, and a thin carbonaceous crust resembling the biosphere and its geological remnants. Particles are made in a stable colloidal form in an aqueous medium, involving chemical precipitation and pyrolysis of citric acid in the solution. The effects of various synthesis parameters were studied, including borohydride and oleate concentrations, APTES/TEOS molar ratio, chemical nature of the carbon precursors, and others...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28007631/on-demand-drug-release-and-hyperthermia-therapy-applications-of-thermoresponsive-poly-nipaam-co-hmaam-polyurethane-core-shell-nanofiber-mat-on-non-vascular-nitinol-stents
#19
Aguilar Ludwig Erik, Amin GhavamiNejad, Chan Hee Park, Cheol Sang Kim
A functional cover made up of core-shell nanofibers with a unique combination of thermoresponsive polymeric shell and stretchable polymeric core for non-vascular nitinol stents that uses an alternating magnetic field (AMF) to induce heat in the stent for hyperthermia therapy and simultaneously release 5-fluorouracil and/or paclitaxel was designed. Varied ratios of NIPAAm to HMAAm monomer resulted in different LCST properties was utilized for an on-demand drug release. Biocompatibility test using NIH-3T3 fibroblast cells indicates that the composite with drug content is biocompatible and the in-vitro cancer cytotoxicity test using ESO26 and OE21 cancer cells proved that the material shows cancer cytotoxic properties via combination of dual drug and hyperthermia therapy...
December 20, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28007550/gemcitabine-selective-cytotoxicity-induction-of-inflammation-and-effects-on-urothelial-function
#20
Stefanie E Farr, Russ Chess-Williams, Catherine M McDermott
Intravesical gemcitabine has recently been introduced for the treatment of superficial bladder cancer and has a favourable efficacy and toxicity profile in comparison to mitomycin c (MMC), the most commonly used chemotherapeutic agent. The aim of this study was to assess the cytotoxic potency of gemcitabine in comparison to MMC in urothelial cell lines derived from non-malignant (UROtsa) and malignant (RT4 and T24) tissues to assess selectivity. Cells were treated with gemcitabine or mitomycin C at concentrations up to the clinical doses for 1 or 2h respectively (clinical duration)...
December 19, 2016: Toxicology and Applied Pharmacology
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