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Leishmaniasis and fluconazol

Marine Ginouvès, Stéphane Simon, Mathieu Nacher, Magalie Demar, Bernard Carme, Pierre Couppié, Ghislaine Prévot
AbstractAnti-leishmaniasis drug resistance is a common problem worldwide. The aim of this study was to inventory the general in vitro level of sensitivity of Leishmania isolates circulating in French Guiana and to highlight potential in vitro pentamidine-resistant isolates. This sensitivity study was conducted on 36 patient-promastigote isolates for seven drugs (amphotericin B, azithromycin, fluconazole, meglumine antimoniate, miltefosine, paromomycin, and pentamidine) using the Cell Counting Kit-8 viability test...
May 2017: American Journal of Tropical Medicine and Hygiene
Fernanda V de O Prates, Mayra E F Dourado, Silvana C Silva, Albert Schriefer, Luiz H Guimarães, Maria das Graças O Brito, Juliana Almeida, Edgar M Carvalho, Paulo R L Machado
BACKGROUND:  The treatment of cutaneous leishmaniasis (CL) caused by Leishmania braziliensis in Brazil with pentavalent antimony (Sb(v)) is associated with a high rate of failure, up to 45% of cases. In addition, Sb(v) can only administered parenterally and has important toxic effect. An effective, safe, and oral treatment for CL is required. METHODS:  A randomized controlled clinical trial was conducted to compare the efficacy and safety of high-dosage oral fluconazole (6...
January 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Anila Chacko, Marissa Joseph, Timothy Feltis, Shaun K Morris
It is challenging to find safe, nonscarring and noninvasive treatment of facial cutaneous leishmaniasis (CL) in children. Herein, we report a child with CL from a region endemic for Leishmania tropica, whose lesion persisted after treatment with oral fluconazole but responded to topical paromomycin. Paromomycin should be considered early for treatment of Old World CL and is a well-tolerated and effective mode of therapy for facial lesions.
October 5, 2016: American Journal of Tropical Medicine and Hygiene
Anastácio Queiroz Sousa, Margarida M Lima Pompeu, Richard D Pearson
No abstract text is available yet for this article.
January 2016: American Journal of Tropical Medicine and Hygiene
Gamze Serarslan, Metin Aksakal
Cutaneous leishmaniasis is a protozoan infectious disease and widespread in Mediterranean basin including Turkey. Lesions usually start with erythematous papules, gradually enlarges and afterwards it ulcerates. We present a 12-year-old boy with diffuse persistent lip swelling mimicking granulomatous cheilitis. Systemic glucantime was started. However, severe hypotension and bradycardia was developed after injection. Oral fluconazole was started and the lesion resolved completely. Cutaneous leishmaniasis can have varied clinical manifestations and should be suspected especially in endemic areas...
2015: Annals of Parasitology
Özlem Ekiz, Emine Nur Rifaioǧlu, Bilge Bülbül Şen, Gülnaz Çulha, Tümay Özgür, Asena Çiǧdem Doǧramaci
Leishmaniasis recidiva cutis (LRC) is an unusual form of acute cutaneous leishmaniasis. Herein, we present a case of LRC of the lips mimicking granulomatous cheilitis. An 8-year-old, Syrian child admitted with a swelling and disfigurement of his lips for 4 years. Abundant intra and extracellular Leishmania amastigotes were determined in the smear prepared from the lesion with Giemsa stain. Histopathology showed foamy histiocytes and leishmania parasites within the cytoplasm of macrophages in the epidermis and a dense dermal mixed type inflammatory cell infiltrate composed of lymphocytes, foamy histiocytes with multinucleated giant cells...
March 2015: Indian Journal of Dermatology
Daniel P Eiras, Laura A Kirkman, Henry W Murray
Leishmaniasis, a protozoal infection transmitted by sandfly bite, produces a clinical spectrum of disease ranging from asymptomatic infection to ulcerative skin and mucosal lesions to visceral involvement. Leishmaniasis is endemic in regions of Africa, the Middle East, south Asia, southern Europe, northern South America, and Central America. There has been an increase in imported leishmaniasis into developed, non-endemic countries due to increasing global travel. While pentavalent antimonials have been the mainstay of antileishmanial treatment for decades, newer therapeutic options have become available for all forms of infection, including liposomal amphotericin B, miltefosine, fluconazole, and ketoconazole...
March 1, 2015: Current Treatment Options in Infectious Diseases
Wajihullah Khan, Haytham A Zakai
BACKGROUND: Cutaneous leishmaniasis is an annoying and disfiguring disease affecting around 1,500,000 individuals globally. There are endemic pockets of this disease in Taif region. In some patients, lesion often weeps and leads to scar formation. The study was conducted to see the efficacy of fluconazole and itraconazole in the patients of cutaneous leishmaniasis and the effect of these drugs on liver enzymes and kidney markers. METHODS: Positivity of Leishmania was recorded by microscopic examinations of smears...
September 2014: Iranian Journal of Parasitology
Marcela Brito Oliveira, Giovana Calixto, Márcia Graminha, Hugo Cerecetto, Mercedes González, Marlus Chorilli
Cutaneous leishmaniasis (CL) is a resistant form of leishmaniasis that is caused by a parasite belonging to the genus Leishmania. FLU-loaded microemulsions (MEs) were developed by phase diagram for topical administration of fluconazole (FLU) as prominent alternative to combat CL. Three MEs called F1, F2, and F3 (F1-60% 50 M phosphate buffer at pH 7.4 (PB) as aqueous phase, 10% cholesterol (CHO) as oil phase, and 30% soy phosphatidylcholine/oil polyoxyl-60 hydrogenated castor oil/sodium oleate (3/8/6) (S) as surfactant; F2-50% PB, 10% CHO, and 40% S; F3-40% PB, 10% CHO, and 50 % S) were characterized by droplet size analysis, zeta potential analysis, X-ray diffraction, continuous flow, texture profile analysis, and in vitro bioadhesion...
2015: BioMed Research International
Anny Fortin, Diana P Caridha, Susan Leed, Franklyn Ngundam, Jenell Sena, Tom Bosschaerts, Sandi Parriott, Mark R Hickman, Thomas H Hudson, Max Grogl
BACKGROUND: Cutaneous leishmaniasis (CL) represents a range of skin diseases caused by infection with Leishmania parasites and associated with tissue inflammation and skin ulceration. CL is clinically widespread in both the Old and New World but lacks treatments that are well tolerated, effective and inexpensive. Oleylphosphocholine (OlPC) is a new orally bioavailable drug of the alkylphosphocholine family with potent antileishmanial activity against a broad range of Leishmania species/strains...
September 2014: PLoS Neglected Tropical Diseases
Olivier Aerts, Nathalie Duchateau, Peter Willemse, Julien Lambert
We report the successful treatment of cutaneous leishmaniasis in a 6-year-old girl who presented with a solitary lesion on the cheek. A low dose of 3 mg/kg/day of fluconazole was used, with remarkable improvement at 6 weeks and complete regression at 12 weeks, excellent cosmetic results, and no relapse during a follow-up of 1 year.
January 2015: Pediatric Dermatology
K Daly, H De Lima, H Kato, E M Sordillo, J Convit, O Reyes-Jaimes, O Zerpa, A E Paniz-Mondolfi
American cutaneous leishmaniasis is an endemic anthropozoonosis that exhibits a broad spectrum of clinical presentations. Intermediate/borderline disseminated cutaneous leishmaniasis is a distinct clinical condition that comprises cutaneous disease of a chronic nature, usually occurring as multiple lesions with or without mucosal involvement. The disease is usually caused by parasites of the subgenus Viannia, frequently occurs in context of an underlying disease, and is often resistant to standard antileishmanial therapy...
August 2014: Clinical and Experimental Dermatology
Sébastien Larréché, Grégoire Launay, Christelle Weibel Galluzzo, Aurore Bousquet, Gilles Eperon, Jean-Etienne Pilo, Christophe Ravel, François Chappuis, Michel Dupin, Audrey Mérens
We report a cluster of cutaneous leishmaniasis due to Leishmania major in four immunocompetent travelers returning from Western Turkmenistan and having atypical and/or multiple lesions. Treatments with pentamidine or fluconazole were effective. Physicians should be aware that some virulent strains of L major currently circulate in Central Asia.
November 2013: Journal of Travel Medicine
V Mosimann, A Neumayr, C Hatz, J A Blum
BACKGROUND: Different species of the genus Leishmania can cause cutaneous (CL) and mucosal leishmaniasis (ML). PCR-based tests allow a rapid diagnosis and determination of the species, thereby enabling species-oriented treatment. Such treatment procedures have not been evaluated to date. METHODS: Patients presenting with CL and ML between 1999 and 2011 were analysed retrospectively. PCR technology was used to diagnose the disease and identify the protozoan to the species level...
December 2013: Infection
W Poeppl, C Oeser, K Grabmeier-Pfistershammer, J Walochnik, H Burgmann
BACKGROUND: The management of cutaneous leishmaniasis in non-endemic countries is challenging due to the wide variety of clinical manifestations and little information available on treatment modalities for travellers. METHODS: Retrospective analysis and follow-up investigation in patients with imported cutaneous leishmaniasis managed at the General Hospital Vienna from 2004 to 2010. RESULTS: In total, 14 patients with cutaneous leishmaniasis were analyzed...
March 2013: Travel Medicine and Infectious Disease
M S Bailey, A J Caddy, K A McKinnon, L F Fogg, M Roscoe, J W Bailey, T J O'Dempsey, N J Beeching
OBJECTIVES: In Afghanistan zoonotic cutaneous leishmaniasis (CL) due to Leishmania major has been less widely reported than anthroponotic CL due to L. tropica. However, an outbreak of zoonotic CL occurred amongst a group of British soldiers at a military camp near Mazar-e-Sharif in the Balkh province of northern Afghanistan in 2004. METHODS: A study was performed to assess the epidemiology, clinical features, parasitology results, treatment outcomes and environmental health measures associated with this incident...
September 2012: Journal of the Royal Army Medical Corps
K Grabmeier-Pfistershammer, W Poeppl, P M Brunner, K Rappersberger, A Rieger
We report on a 37-year-old male HIV-positive patient with generalized cutaneous leishmaniasis undiagnosed for several years. Upon presentation, visceral leishmaniasis was diagnosed in addition to cutaneous manifestation of the disease. Over a period of three years, several different treatment regimens including liposomal amphotericin B, liposomal amphotericin B with miltefosine, liposomal amphotericin B with interferon, and pentamidine combined fluconazole and allopurinol were applied until Leishmania PCR from blood turned negative...
2012: Case Reports in Infectious Diseases
Aida Khaled, Samia Goucha, Sonia Trabelsi, Rachida Zermani, Bécima Fazaa
BACKGROUND: Lupoid cutaneous leishmaniasis (CL) is a rare form of CL having a striking resemblance to other granulomatous cutaneous conditions of infectious or inflammatory origin. The authors present a patient with a facial lupoid CL and discuss the diagnostic tools of this parasitological infection, the main differential diagnosis, and treatment. CASE REPORT: A 54-year-old Tunisian woman, with no past medical history of lupus erythematosus or infectious disease, presented with a 3-month history of a slowly enlarging erythematous and infiltrated plaque, extending over the nose, the right cheek, and the internal aspect of the right lower eyelid...
December 2011: Dermatology and Therapy
Soumaya Yaich, Khaled Charfeddine, Abderrahmen Masmoudi, Mondher Masmoudi, Sawssen Zaghdhane, Hamida Turki, Jamil Hachicha
Leishmaniasis is a zoonotic infection acquired through the bite of a female sandfly, which introduces the amastigotes of Leishmania into the bloodstream. Cutaneous leishmaniasis is rare after solid organ transplantation. Its diagnosis is difficult in immunosuppressed patients. We report a case of isolated cutaneous leishmaniasis in a renal transplant patient resident in an endemic area. The patient was successfully treated with allopurinol and fluconazole and has remained relapse-free for 44 months. The diagnosis of cutaneous leishmaniasis must be considered in immunosuppressed patients living in endemic areas...
March 2013: Annals of Saudi Medicine
Mahsa Ansari, Saeed Emami, Mohammad A Khalilzadeh, Malek T Maghsoodlou, Alireza Foroumadi, Mohammad A Faramarzi, Nasrin Samadi, Sussan K Ardestani
With the aim of finding new bioactive compounds, a series of phenoxyacetophenone derivatives 2 were designed and synthesized as oxygen analogs of dihydrochalcones. Also, phenoxyacetophenones were converted to (Z)-oxime derivatives 3 and their geometry were characterized by ¹H-NMR spectroscopy. The in vitro antifungal activity of compounds 2 and 3 was evaluated against Candida albicans, Candida glabrata, Saccharomyces cerevisiae, and Aspergillus niger using micro-dilution method. In general, oxime derivative 3d containing 4-fluorophenoxy moiety showed comparable or more potent antifungal activity (MICs = 15...
October 2012: Chemical Biology & Drug Design
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