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Laura Leci-Tahiri, Harieta Zherka-Saracini, Afrim Tahiri, Adhurim Koshi
BACKGROUND: The aim of the study was to analyze characteristics of patients with bilateral internal jugular vein thrombosis in our department during a 1-year period. Internal jugular vein thrombosis refers to an intraluminal thrombus occurring anywhere from the intracranial internal jugular vein to the junction of the internal jugular vein and the subclavian vein, which form the brachiocephalic vein. It can occur spontaneously or as a complication of head and neck infections, surgery, central venous lines, local malignancy, polycytemia, hyperhomocysteinemia, neck massage, or intravenous drug abuse...
February 20, 2018: Journal of Medical Case Reports
S Ruberti, E Bianchi, P Guglielmelli, S Rontauroli, G Barbieri, L Tavernari, T Fanelli, R Norfo, V Pennucci, G Corbizi Fattori, C Mannarelli, N Bartalucci, B Mora, L Elli, M A Avanzini, C Rossi, S Salmoiraghi, R Zini, S Salati, Z Prudente, V Rosti, F Passamonti, A Rambaldi, S Ferrari, E Tagliafico, A M Vannucchi, R Manfredini
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by hyperplastic megakaryopoiesis and myelofibrosis. We recently described the upregulation of MAF (v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog) in PMF CD34+ hematopoietic progenitor cells (HPCs) compared to healthy donor. Here we demonstrated that MAF is also upregulated in PMF compared with the essential thrombocytemia (ET) and polycytemia vera (PV) HPCs. MAF overexpression and knockdown experiments shed some light into the role of MAF in PMF pathogenesis, by demonstrating that MAF favors the megakaryocyte and monocyte/macrophage commitment of HPCs and leads to the increased expression of proinflammatory and profibrotic mediators...
February 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Massimo Cajozzo, Vincenzo Davide Palumbo, Salvatore Buscemi, Giuseppe Damiano, Ada Maria Florena, Daniela Cabibi, Francesco Raffaele, Antonino Alessio Anzalone, Federica Fatica, Gerlando Cocchiara, Salvatore Dioguardi, Antonio Bruno, Francesco Paolo Caronia, Attilio Ignazio Lo Monte
BACKGROUND: Plasmoblastic lymphoma is a rare and aggressive subtype of diffuse large B cell lymphoma, which occurs usually in the jaw of immunocompromised subjects. CASE PRESENTATION: We describe the occurrence of plasmoblastic lymphoma in the mediastinum and chest wall skin of an human immunodeficiency virus-negative 63-year-old Caucasian man who had had polycytemia vera 7 years before. At admission, the patient showed a superior vena cava syndrome, with persistent dyspnoea, cough, and distension of the jugular veins...
March 21, 2017: Journal of Medical Case Reports
Nicola Persico, Isabella Fabietti, Francesco D'Ambrosi, Maria Riccardi, Simona Boito, Luigi Fedele
BACKGROUND: Endoscopic laser coagulation of placental anastomoses is the first-line treatment for severe twin-to-twin transfusion syndrome. A recent randomized controlled trial reported that laser coagulation along the entire vascular equator was associated with a similar dual survival and survival of at least 1 twin compared with the group that was treated with the selective technique. In addition, there was a significantly lower incidence of postoperative recurrence of twin-to-twin transfusion syndrome and the development of twin anemia-polycythemia sequence in the equatorial group...
April 2016: American Journal of Obstetrics and Gynecology
I Vlašínová, L Hruban, P Janků, R Gerychová, P Ventruba, V Ťápalová, Z Hodická
OBJECTIVE: Purpose of this study was to determine the frequency of occurence of specific complications of monochorionic diamniotic twins born after 24 weeks of pregnancies and the effect of these complications on perinatal morbidity and mortality. TYPE OF STUDY: Restrospective analysis. SETTING: Dpt. of Obstetrics and Gynecology Masaryk University and University Hospital Brno. METHODOLOGY: A retrospective analysis of 175 monochorionic diamniotic pregnancies (mo-bi), which were terminated after the 24th week of pregnancy at the Department of Obstetrics and Gynecology Masaryk University and University Hospital Brno between the years 2008-2013...
June 2015: Ceská Gynekologie
Roberto Castelli, Massimo Cugno, Umberto Gianelli, Alessandro Pancrazzi, Alessandro Maria Vannucchi
BACKGROUND: In a small subset of polycytemia vera (PV), neutrophilia not secondary to reactive conditions or treatment can develop and persist. Clinical significance and morphogenetic alterations associated with this uncommon phenomenon are not well defined. CASE REPORT: An 81-year-old Caucasian woman, affected by polycytemia vera lasting 17 years, presented in March 2012 with hyperleukocytosis, absolute neutrophilia, and thrombocytosis despite hydroxyurea treatment...
April 2015: Pathology, Research and Practice
Claudia Izzi, Nadia Dallera, Chiara Manenti, Gianluca Caridi, GianMarco Ghiggeri, Luca Rampoldi, Francesco Scolari
No abstract text is available yet for this article.
October 2014: Kidney International
I A Lurin, H H Makarov, O I Hladyshenko, V P Slobodianyk
No abstract text is available yet for this article.
November 2013: Klinichna Khirurhiia
M S Opanasenko, V I Klymenko, R S Demus, B M Konik, O V Tereshkovych, M I Kalenychenko, V B Bychkovs'kyĭ, O K Obrems'ka, L I Levanda, V A Kononenko, O E Kshanovs'kyĭ, I Iu Mykytenko
Arteriovenous fistulas (AVF)--a rare inborn disease of respiratory system. During 32 yrs 19 observations of pulmonary AVF were made. There were 13 (68.4%) men and 6 (31.6%) women. The patients' age was 25 yrs at average. In 4 (21.1%) patients there was Rendu-Weber-Osler disease diagnosed. Characteristic complaints were acrocyanosis, dyspnea while on loading, rapid fatigue. In accordance to laboratory investigation performed, polycytemia and hypoxemia were revealed. All the patients were operated on, most frequent operation was lobectomy--in 14 (73...
November 2013: Klinichna Khirurhiia
Miguel Gallardo, Santiago Barrio, Marisol Fernandez, Alberto Paradela, Alicia Arenas, Oscar Toldos, Rosa Ayala, Enriqueta Albizua, Ana Jimenez, Santiago Redondo, Rosa Maria Garcia-Martin, Florinda Gilsanz, Juan Pablo Albar, Joaquin Martinez-Lopez
JAK-STAT signaling through the JAK2V617F mutation is central to the pathogenesis of myeloproliferative neoplasms (MPN). However, other events could precede the JAK2 mutation. The aim of this study is to analyze the phenotypic divergence between polycytemia vera (PV) and essential thrombocytemia (ET) to find novel therapeutics targets by a proteomic and functional approach to identify alternative routes to JAK2 activation. Through 2D-DIGE and mass spectrometry of granulocyte protein from 20 MPN samples, showed differential expression of HSP70 in PV and ET besides other 60 proteins...
November 19, 2013: Molecular Cancer
Rob van Zwieten, Martijn Veldthuis, Barend Delzenne, Jeffrey Berghuis, Joke Groen, Fatima Ait Ichou, Els Clifford, Cornelis L Harteveld, An K Stroobants
More than 20,000 blood samples of individuals living in The Netherlands and suspected of hemolytic anemia or diabetes were analyzed by high resolution cation exchange high performance liquid chromatography (HPLC). Besides common disease-related hemoglobins (Hbs), rare variants were also detected. The variant Hbs were retrospectively analyzed by capillary zone electrophoresis (CZE) and by isoelectric focusing (IEF). For unambiguous identification, the globin genes were sequenced. Most of the 80 Hb variants detected by initial screening on HPLC were also separated by capillary electrophoresis (CE), but a few variants were only detectable with one of these methods...
2014: Hemoglobin
The erythrocyte sedimentation rate (ESR) is a time-honored blood test, which assesses the degree of erythrocyte aggregation by acute phase proteins such as fibrinogen and immunoglobulins. Various intrinsic factors may influence the ESR, among them polycytemia, microcytosis or fibrinogen consumption lead to a decreased ESR, while anemia, macrocytosis or hypoalbuminemia lead to an increased ESR. The ESR still is a very valid test for the diagnosis of certain chronic diseases (polymyalgia, rheumatoid arthritis, multiple myeloma, septic arthritis and ostemyelitis) and the follow-up of certain chronic diseases (polymyalgia rheumatica, systemic lupus erythematodes, chronic infections, prostatic cancer, and Hodgkin's disease)...
January 1, 2006: Therapeutische Umschau. Revue Thérapeutique
J-J Lehot, B Was, L Dendeleu, O Jegaden
A 55-year-old male with a history of positive HIV serology and polycythemia vera underwent coronary artery bypass graft surgery with normothermic extracorporeal circulation. Following heparin administration the activated clotting time (ACT) was 633 seconds (Hemocron with kaolin). Lower than expected arterial and venous oxygen partial pressures together with high pressure (350 mmHg) in the arterial line upstream of the oxygenator were observed. Because of these signs the oxygenator was changed during the procedure...
May 2012: Annales Françaises D'anesthèsie et de Rèanimation
I Ben Ghorbel, T Ben Salem, M Lamloum, M Khanfir, A Braham, M Miled, N Ben Romdhane, M H Houman
Neurological manifestations in polycytemia vera are common. However, chorea is an exceptionally revealing feature of this disease. We report a 78-year-old man who presented with headache and an abnormal movement disorder corresponding to chorea. Laboratory findings showed increased levels of hemoglobin at 20 g/dl and hematocrit at 62.3%. An elevated erythrocyte mass to twice the normal value demonstrated the absolute erythrocytosis. A JAK2 V617F gene mutation was identified. A diagnosis of polycytemia vera-associated chorea was obtained...
June 2011: La Revue de Médecine Interne
Salvatore Lentini, Mario Barone, Filippo Benedetto, Francesco Spinelli
Polycythemia vera is a myeloproliferative disorder characterized by thrombotic complications both in the arterial and venous systems. We report the case of a 55-year-old patient affected by polycythemia vera, presenting with acute superior vena cava syndrome due to thrombosis of the upper part of the superior vena cava. Diagnosis was done clinically and by computed tomography scan and showed an unusual finding: an air bubble trapped in the brachiocephalic venous trunk. The patient underwent emergency surgery...
2010: Cardiology Research and Practice
Iu M Zakharov, I V Feklicheva
The sensibility to erythropoietin oferythroblastic islands of bone marrow which were made in different terms after the creation of transfusion polycytemia is researched. It turned out that the central macrophags of involuting erythroblastic islands are more sensible to erythropoietin than residual macrophags of bone marrow. The capability of residual macrophags to form erythroblastic islands is opened to the bigger inhibitory influence during the development of transfusion polycytemia than to the central macrjphags of involuting erythroblastic islands...
November 2009: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
Iu M Zakharov, I V Feklicheva
The effect of experimental inhibition of the erythropoiesis on ability of the erythroide "crown" cells of erythroblast islands of the bone marrow to respond to the erythropoietin by the increase of the proliferative activity was studied. It was discovered that this ability depended on the degree of the erythropoiesis inhibition and on the class of the erythroblast island maturity. In the culture of the erythroblast islands of the bone marrow on the second 24-hour period after transfusion polycytemia reproduction, the proliferative activity of the erythroid cells in response to brining of the erythropoietin to the culture increased more in the erythroblast islands of the first and second maturity classes than in the reconstructing the erythroblast islands...
September 2009: Rossiĭskii Fiziologicheskiĭ Zhurnal Imeni I.M. Sechenova
Claudia Buzas, Zeno Sparchez, Andrei Cucuianu, Simona Manole, Ioana Lupescu, Monica Acalovschi
Budd-Chiari syndrome still represents a challenge for the hepatologist with regard to its causes and its most effective therapy. Polycythemia vera is considered to be the most frequent condition causing the Budd-Chiari syndrome (10-40% of cases). We present a 34-year-old patient in post-partum who was admitted for right upper abdominal quadrant pain and asthenia. Laboratory data, abdominal echography and angioMRI all raised the suspicion of BCS, but it was in the haematological department that polycytemia vera was diagnosed as the cause of the hepatic condition...
September 2009: Journal of Gastrointestinal and Liver Diseases: JGLD
Magnus Tobiasson, Bassam Alyass, Susanne Söderlund, Gunnar Birgegård
In order to examine whether symptoms of iron deficiency anemia are due to the iron deficiency itself or the associated anemia, 34 patients with polycytemia vera (PV) treated with venesectio, who had iron deficiency but normal hemoglobin (Hb) levels, were given a questionnaire covering symptoms of iron deficiency including the international RLS-scale and the Fact-fatigue quality of life scale (QoL). We found a prevalence of pica of 11.7%, mouth paresthesias of 5.8% and rest-less legs 29.6% (RLS "normal" prevalence 10%)...
March 2010: Medical Oncology
Gábor Késmárky, Péter Kenyeres, Miklós Rábai, Kálmán Tóth
Evaluation of plasma viscosity has been underutilized in the clinical practice. Plasma viscosity is determined by water-content and macromolecular components. Plasma is a highly concentrated protein solution, therefore weak protein-protein interactions can play a role that is not characterized by electrophoresis. The effect of a protein on plasma viscosity depends on its molecular weight and structure. The less spheroid shape, the higher molecular weight, the higher aggregating capacity, and the higher temperature or pH sensitivity a protein has, the higher plasma viscosity results...
2008: Clinical Hemorheology and Microcirculation
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