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https://www.readbyqxmd.com/read/28224275/the-english-national-screening-programme-for-diabetic-retinopathy-2003-2016
#1
Peter H Scanlon
The aim of the English NHS Diabetic Eye Screening Programme is to reduce the risk of sight loss amongst people with diabetes by the prompt identification and effective treatment if necessary of sight-threatening diabetic retinopathy, at the appropriate stage during the disease process. In order to achieve the delivery of evidence-based, population-based screening programmes, it was recognised that certain key components were required. It is necessary to identify the eligible population in order to deliver the programme to the maximum number of people with diabetes...
February 22, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28217268/anti-musk-positive-myasthenia-gravis-and-three-semiological-cardinal-signs
#2
André P C Matta, Ana C Andorinho F Ferreira, Arielle Kirmse, Anna Carolina Damm, João Gabriel D I B Farinhas, Mariane D Barbosa, Mayara C M Teles, Camila Fiorelli, Rossano Fiorelli, Osvaldo J M Nascimento, Marco Orsini
Myasthenia gravis (MG) is a relatively uncommon disorder with an annual incidence of approximately 7 to 9 new cases per million. The prevalence is about 70 to 165 per million. The prevalence of the disease has been increasing over the past five decades. This is thought to be due to better recognition of the condition, aging of the population, and the longer life span of affected patients. MG causes weakness, predominantly in bulbar, facial, and extra-ocular muscles, often fluctuating over minutes to weeks, in the absence of wasting, sensory loss, or reflex changes...
November 2, 2016: Neurology International
https://www.readbyqxmd.com/read/28209503/lymphoma-of-the-eyelid-an-international-multicenter-retrospective-study
#3
Frederik Holm Svendsen, Peter Kristian Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Santosh G Honavar, Jwu Jin Khong, Penelope A McKelvie, Kaustubh Mulay, Elisabeth Ralfkiaer, Lene Dissing Sjö, Geeta K Vemuganti, Bradley A Thuro, Jeremy Curtin, Steffen Heegaard
PURPOSE: To document subtype-specific clinical features of lymphoma of the eyelid, and their effect on patient outcome. DESIGN: Retrospective observational case series. METHODS: Patient data were collected from 7 international eye cancer centers from January 1st 1980 through December 31st 2015. The cases included primary and secondary lymphomas affecting the eyelid. Overall survival, disease-specific survival (DSS), and progression-free survival were the primary end points...
February 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28205422/ophthalmologic-wax-models-as-an-educational-tool-for-18th-century-vision-scientists
#4
Fabio Zampieri, Francesco Comacchio, Alberto Zanatta
The Medical Faculties of the University of Padua (Italy) and the University of Vienna (Austria) preserved two series of wax models, made by the Austrian Johann Nepomuk Hoffmayr at the beginning of the 19th century. These models were created in a period of evolution of both medical specialties and organ pathology, which brought morbid organs at the centre of medical investigation. Ceroplastic was considered a useful tool for didactic and research, as it provided a three-dimensional realistically coloured reproduction of organic lesions...
February 16, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28195263/kikuchi-fujimoto-disease-a-clinicopathologic-update
#5
F Pepe, S Disma, C Teodoro, P Pepe, G Magro
Kikuchi-Fujmoto disease (KFD), also known as "histiocytic necrotizing lymphadenitis", is a rare lymphadenitis of unknown origin, but with an excellent prognosis. It is more common in Asia, but isolated cases are also reported in America, Africa and Europe. The disease can have an acute or subacute course, usually develops in 1 to 3 weeks, with spontaneous resolution in 1-4 months. The main clinical sign is cervical lymphadenopathy, especially in the posterior cervical triangle with bulky and painful lymph nodes, usually affecting only one side; rare cases of generalized lymphadenopathy can be seen...
September 2016: Pathologica
https://www.readbyqxmd.com/read/28190674/neuronal-loss-and-%C3%AE-synuclein-pathology-in-the-superior-colliculus-and-its-relationship-to-visual-hallucinations-in-dementia-with-lewy-bodies
#6
Daniel Erskine, Alan J Thomas, John-Paul Taylor, Michael A Savage, Johannes Attems, Ian G McKeith, Christopher M Morris, Ahmad A Khundakar
OBJECTIVE: Patients with dementia with Lewy bodies (DLB) often experience visual hallucinations, which are related to decreased quality of life for patients and increased caregiver distress. The pathologic changes that contribute to visual hallucinations are not known, but several hypotheses implicate deficient attentional processing. The superior colliculus has a role in visual attention and planning eye movements and has been directly implicated in several models of visual hallucinations...
January 10, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28166160/predictive-factors-for-development-of-neovascular-age-related-macular-degeneration-a-spectral-domain-optical-coherence-tomography-study
#7
Serena Fragiotta, Tommaso Rossi, Alessandro Cutini, Pier L Grenga, Enzo M Vingolo
PURPOSE: To investigate the risk factors predictive for the development of neovascular age-related macular degeneration (NVAMD) by means of spectral-domain optical coherence tomography. METHODS: Retrospective study of 73 eyes graded Stage 2 and Stage 3 according to the AMD International Grading System with minimum follow-up of 24 months. Drusenoid pigment epithelial detachment, hyperreflective foci, external limiting membrane, inner ellipsoid band, and retinal pigment epithelium integrity were analyzed at baseline and last follow-up...
February 3, 2017: Retina
https://www.readbyqxmd.com/read/28165853/biocompatibility-and-characterization-of-polyglycerol-based-thermoresponsive-nanogels-designed-as-novel-drug-delivery-systems-and-their-intracellular-localization-in-keratinocytes
#8
Christian Gerecke, Alexander Edlich, Michael Giulbudagian, Fabian Schumacher, Nan Zhang, Andre Said, Guy Yealland, Silke B Lohan, Falko Neumann, Martina C Meinke, Nan Ma, Marcelo Calderón, Sarah Hedtrich, Monika Schäfer-Korting, Burkhard Kleuser
Novel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse consequences of their exposure must be elucidated. In this study, tNGs were synthesized from dendritic polyglycerol (dPG) and two thermoresponsive polymers...
February 6, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28148953/retinopathy-signs-improved-prediction-and-reclassification-of-cardiovascular-disease-risk-in-diabetes-a-prospective-cohort-study
#9
Henrietta Ho, Carol Y Cheung, Charumathi Sabanayagam, Wanfen Yip, Mohammad Kamran Ikram, Peng Guan Ong, Paul Mitchell, Khuan Yew Chow, Ching Yu Cheng, E Shyong Tai, Tien Yin Wong
CVD risk prediction in diabetics is imperfect, as risk models are derived mainly from the general population. We investigate whether the addition of retinopathy and retinal vascular caliber improve CVD prediction beyond established risk factors in persons with diabetes. We recruited participants from the Singapore Malay Eye Study (SiMES, 2004-2006) and Singapore Prospective Study Program (SP2, 2004-2007), diagnosed with diabetes but no known history of CVD at baseline. Retinopathy and retinal vascular (arteriolar and venular) caliber measurements were added to risk prediction models derived from Cox regression model that included established CVD risk factors and serum biomarkers in SiMES, and validated this internally and externally in SP2...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28146362/epiphora-as-first-presenting-sign-of-primary-extranodal-nk-t-cell-lymphoma-of-the-lacrimal-sac
#10
Mikel Mikhail, René P Michel, Jeffrey Chankowsky, Bryan Arthurs
A 28-year-old Caucasian female presented with a six-month history of epiphora of the right eye. Diagnostic lacrimal syringing revealed obstruction of the right nasolacrimal duct. During external dacryocystorhinostomy (DCR), the lacrimal sac had an unusual papillary appearance. Frozen sections suggested malignant lymphoid cells. Pathologic examination revealed extranodal NK/T-cell lymphoma, nasal type. Imaging revealed a mass lesion centered on the lacrimal sac. The authors describe the youngest Caucasian patient with a primary NK/T-cell lymphoma of the lacrimal sac, as well as the first case presenting with epiphora as the sole presenting symptom, reported in the literature...
February 1, 2017: Orbit
https://www.readbyqxmd.com/read/28133888/alterations-of-the-outer-retina-in-non-arteritic-anterior-ischemic-optic-neuropathy-detected-using-spectral-domain-optical-coherence-tomography
#11
Philipp Ackermann, Maike Brachert, Philipp Albrecht, Marius Ringelstein, David Finis, Gerd Geerling, Orhan Aktas, Rainer Guthoff
BACKGROUND: Changes in peripapillary and macular retinal layer thickness in non-arteritic anterior ischemic optic neuropathy (NAION) measured using spectral-domain optical coherence tomography may reflect a characteristic disease pattern. Advanced software enables retinal layer segmentation. In this study, we compared retinal layer thicknesses in acute and chronic NAION. DESIGN: A single-center cross-sectional analysis in a university clinic. PARTICIPANTS: 14 eyes with acute (<7 days) and 13 eyes with chronic NAION and 20 age-matched healthy eyes...
January 30, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28133071/-primary-malignant-melanoma-of-the-gallbladder
#12
Daisuke Ujiie, Kotaro Miyamoto, Hisashi Onozawa, Nobuhiro Hoshi, Koichi Nakayama, Kojiro Urazumi, Seiichi Takenoshita, Takashi Kusakabe
Primary malignant melanoma of the gallbladder is a rare disease, and 37 cases have been reported in the literature.The current patient was a 78-year-old man who was admitted with a pelvic tumor and left leg edema due to compression of the external iliac vein by the pelvic tumor.The edema improved following resection of the tumor, which was diagnosed at pathology as a malignant melanoma.After surgery, the patient became anorexic and complained of discomfort in the upper right abdomen.A whole body FDG-PET scan demonstrated significant uptake in the gallbladder and in the lymph nodes of the lower abdomen...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28089679/efficacy-and-toxicity-of-intravitreous-chemotherapy-for-retinoblastoma-four-year-experience
#13
Jasmine H Francis, Scott E Brodie, Brian Marr, Emily C Zabor, Ijah Mondesire-Crump, David H Abramson
PURPOSE: To investigate the efficacy and toxicity of intravitreous melphalan for treatment of retinoblastoma, as a single agent or with concomitant topotecan. PARTICIPANTS: A total of 130 eyes of 120 patients with retinoblastoma receiving 630 intravitreous (melphalan, topotecan) or topotecan periocular injections. A total of 83 (64%) of these eyes were treated with concomitant ophthalmic artery chemosurgery (OAC). DESIGN: Retrospective cohort study...
January 12, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28058762/vernal-like-conjunctivitis-in-a-western-lowland-gorilla-gorilla-gorilla-gorilla
#14
Jane S Hopper, Ellen Holding, Emma J Scurrell, Heidi Featherstone
CASE DESCRIPTION: A 17-year-old female western lowland gorilla presented with bilateral ocular discharge, conjunctivitis, and rhinitis that was investigated and treated over a 34-month period. Clinical findings, diagnostic results, treatment, and follow-up are described. CLINICAL FINDING: A mild intermittent mucoid ocular discharge was initially noted. 10 months later, conjunctival hyperemia and thickening developed and progressed rapidly to a mass-like lesion covering the right eye...
January 5, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28034080/ocular-salvage-and-vision-preservation-using-a-topotecan-based-regimen-for-advanced-intraocular-retinoblastoma
#15
Rachel C Brennan, Ibrahim Qaddoumi, Shenghua Mao, Jianrong Wu, Catherine A Billups, Clinton F Stewart, Mary Ellen Hoehn, Carlos Rodriguez-Galindo, Matthew W Wilson
Purpose To evaluate topotecan-based therapy for advanced intraocular retinoblastoma. Patients and Methods Twenty-seven patients with bilateral retinoblastoma (male patients, n = 14; median age, 8.4 months) received chemotherapy: two courses of topotecan plus vincristine followed by three alternating administrations of carboplatin and vincristine for two courses and topotecan plus vincristine for one course, with optional periocular carboplatin. Focal therapy was applied after cycle 2. Event-free survival was defined as avoidance of external-beam radiotherapy (EBRT) and enucleation...
January 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28019092/systemic-neoadjuvant-chemotherapy-for-group-b-intraocular-retinoblastoma-aret0331-a-report-from-the-children-s-oncology-group
#16
Debra L Friedman, Mark Krailo, Doojduen Villaluna, Dan Gombos, Bryan Langholz, Rima Jubran, Carol Shields, Linn Murphree, Joan O'Brien, Sandra Kessel, Carlos Rodriguez-Galindo, Murali Chintagumpala, Anna T Meadows
PURPOSE: To evaluate a chemoreduction regimen using systemic vincristine and carboplatin (VC) and local ophthalmic therapies to avoid external-beam radiotherapy (EBRT) or enucleation in patients with Group B intraocular retinoblastoma. PATIENTS AND METHODS: Twenty-one patients (25 eyes) were treated with six cycles of VC, accompanied by local ophthalmic therapies after cycle 1. The primary study objective was to determine the 2-year event-free survival (EFS) where an event was defined as the use of systemic chemotherapy in addition to vincristine or carboplatin, EBRT, and/or enucleation...
December 26, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28009404/vogt-koyanagi-harada-syndrome-uveomeningoencephalitic-syndrome
#17
Katerina Manethova, Jan Ernest, Michal Hrevus
PURPOSE: To report a case of a 29-year-old man who was examined at the Eye Clinic of Central Military University Hospital Prague for a severe headache and acute blurring of vision in both eyes diagnosed as incomplete Vogt-Koyanagi-Harada syndrome (VKH). METHODS: This is a retrospective and descriptive case report based on data from clinical records, patient observation and follow-ups and analysis of acquired diagnostic tests. RESULTS: A 29-year-old man presented with headache and decreased vision in his left eye (LE) for 2 days...
January 19, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28009348/the-state-of-ocular-health-among-london-s-homeless-population
#18
N Sawers
PurposeTo investigate the demographics, visual impairment, and diagnoses of patients presenting to Vision Care for Homeless People (VCHP), Crisis clinics for London's under-researched homeless population.Patients and methodsTwo hundred eighty-three patients records, including data on sociodemographic, diabetic status, visual acuity, and ocular examination, via a comprehensive eye test were reviewed from the VCHP clinics held at 10 London 'Crisis at Christmas' centres in 2014.ResultsTwo hundred eighty-three individual patients were seen at the VCHP clinics...
December 23, 2016: Eye
https://www.readbyqxmd.com/read/27977837/optical-coherence-tomography-angiography-in-a-normal-iris
#19
Davide Allegrini, Giovanni Montesano, Alfredo Pece
BACKGROUND AND OBJECTIVE: Optical coherence tomography angiography (OCTA) is a new imaging technique for examining the macular region in many retinal diseases. The aim of this study was to assess the applicability of OCTA to detect iris vascularization. PATIENTS AND METHODS: The irises of 28 eyes of 14 patients were examined with AngioVue OCT (Optovue, Fremont, CA). The usual technique was modified using the AngioRetina mode, but with the anterior segment optical adaptor lens, and without autofocus, while making manual adjustments...
December 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27975266/identification-of-tau-toxicity-modifiers-in-the-drosophila-eye
#20
Pierre Dourlen
Drosophila is a powerful model to study human diseases thanks to its genetic tools and ease of screening. Human genes can be expressed in targeted organs and their toxicity assessed on easily scorable external phenotypes that can be used as readout to perform genetic screen of toxicity modifiers. In this chapter, I describe how to express human Tau protein in the Drosophila eye, assess protein expression by western blot, assess Tau toxicity by quantifying the size of the Tau-induced rough eye, and perform a genetic screen of modifiers of Tau toxicity in the Drosophila eye...
2017: Methods in Molecular Biology
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