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https://www.readbyqxmd.com/read/29121219/clinicopathological-features-of-ocular-adnexal-mantle-cell-lymphoma-in-an-international-multicenter-cohort
#1
Marina K H Knudsen, Peter K Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Jwu Jin Khong, Penny A McKelvie, Kaustubh Mulay, Elisabeth Ralfkiaer, Lene D Sjö, Geeta K Vemuganti, Bradley A Thuro, Jeremy Curtin, Steffen Heegaard
Importance: To our knowledge, the clinical features of ocular adnexal mantle-cell lymphoma (OA-MCL) have not previously been evaluated in a large multicenter cohort. Objective: To characterize the clinical features of OA-MCL. Design, Setting, and Participants: This retrospective multicenter study included patient data collected from January 1, 1980, through December 31, 2015, at 6 eye cancer centers in 4 countries. Medical records of 55 patients with OA-MCL were reviewed; the median length of follow-up was 33 months...
November 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29108394/comparative-study-of-3-exophthalmometers-and-computed-tomographic-biometry
#2
Juliette Delmas, Jean-Marie Loustau, Sylvain Martin, Loïc Bourmault, Jean-Paul Adenis, Pierre-Yves Robert
PURPOSE: Accurate and reproducible exophthalmometry is mandatory to diagnose and follow-up orbital patients, especially in Graves disease. However, many variations are described among the different commercially available exophthalmometers. METHODS: Sixty patients, who underwent a cerebral computed tomography (CT) scan, were included. External prebicanthal segments (EPBCS) for right and left eyes (RE and LE), interorbital distance, and globe axial length were recorded by a first observer (O1), more experienced than a second (O2)...
November 2, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29101007/epidemiology-of-primary-ophthalmic-inpatient-admissions-in-the-united-states
#3
Mustafa Iftikhar, Nadia Junaid, Marili Lemus, Zyannah N Mallick, Syeda A Mina, Urooba Hannan, Joseph K Canner, Asad Latif, Syed Mahmood Ali Shah
PURPOSE: To determine the national estimates, demographics and costs of inpatient eye care in the United States (US). DESIGN: Retrospective cross-sectional study. METHODS: National Inpatient Sample (NIS), a representative sample of all US community hospitals, was used to analyze inpatient admissions with a primary ophthalmic diagnosis from 2001 to 2014. National estimates of the most prevalent diagnoses were determined, and descriptive statistics were calculated for demographics and costs...
October 31, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29064950/epidemiology-of-reduced-visual-acuity-among-chinese-multiethnic-students
#4
Deng-Juan Qian, Min Hu, Hua Zhong, Qiao Nie, Jun Li, Yuansheng Yuan, Chen-Wei Pan
SIGNIFICANCE: Data regarding the epidemiology of reduced visual acuity (VA) among multiethnic children and adolescents in China are few. Understanding the vision-related health inequalities among different ethnic groups is crucial for health resource allocations and clinical managements for eye diseases. PURPOSE: We aim to determine the prevalence, main causes, and health inequalities of reduced VA in multiethnic school students in rural China. METHODS: A school-based eye survey including 7681 multiethnic school students aged 5 to 16 years in the southwestern part of China was conducted...
October 23, 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29053974/depression-as-seen-through-the-eyes-of-rural-chinese-women-implications-for-help-seeking-and-the-future-of-mental-health-care-in-china
#5
Peiyuan Qiu, Eric D Caine, Fengsu Hou, Catherine Cerulli, Marsha N Wittink
BACKGROUND: As part of a larger epidemiological study of depression among rural Chinese women, we sought to understand their explanatory models of depression. We explored how participants describe depression, to what cause they attribute depression, and what sources of treatment they would recommend. METHODS: Participants first were assessed with the Center for Epidemiological-Depression scale (CES-D), with a cut-point of 16 or greater indicative of depression. The Short Explanatory Model Interview (SEMI), a semi-structured questionnaire, was our primary tool for exploring participants' explanatory models relating to a vignette describing a rural Chinese woman with depression...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053687/bead-based-multiplex-assay-for-analysis-of-tear-cytokine-profiles
#6
Praveen Kumar Balne, Veonice Bijin Au, Louis Tong, Arkasubhra Ghosh, Mukesh Agrawal, John Connolly, Rupesh Agrawal
Tear film is a complex mixture of lipids, proteins and minerals which covers the external surface of the eye, thereby providing lubrication, nutrition and protection to the underlying cells. Analysis of tears is an emerging area for the identification of biomarkers for the prediction, diagnosis, and prognosis of various ocular diseases. Tears are easily accessible and their collection is non-invasive. Therefore, advancing technologies are gaining prominence for identification of multiple analytes in tears to study changes in protein or metabolite composition and its association with pathological conditions...
October 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29037595/cellular-characterization-of-optical-coherence-tomography-and-outer-retinal-bands-using-specific-immunohistochemistry-markers-and-clinical-implications
#7
Nicolás Cuenca, Isabel Ortuño-Lizarán, Isabel Pinilla
PURPOSE: Optical coherence tomography has been a technological breakthrough in the diagnosis, treatment, and follow-up of many ocular diseases, especially retinal and neuro-ophthalmologic pathologic conditions. Until now, several controversies have arisen over the specific cell types that the bands observed in the OCT represent, especially over the 4 outer retinal bands. DESIGN: To correlate the 4 outer hyperreflective bands observed in the OCT with the histologic structures using human retinal sections and immunocytochemistry at the fovea level...
October 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29018015/chronic-red-eye-a-masquerade-of-advanced-neoplastic-disease
#8
Joana Providência, Filipa Ponces, Guilherme Castela, Joaquim Murta
A 42-year-old woman presented with chronic history of left red eye for more than 12 months, treated with difference topical medication but without response. Ocular external examination demonstrated a firm palpable mass in the medial portion of the lower eyelid and slit-lamp evaluation of the lesion showed an ulcerated conjunctival nodule, keratin secretor. CT of the orbits revealed left-sided orbital mass located anteriorly, inferiorly and medially in the orbit, adjacent to the globe and orbit walls. Incisional biopsy of the lesion was consistent with invasive squamous cell carcinoma of the conjunctiva...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28956287/use-of-the-controlled-adverse-environment-cae-in-clinical-research-a-review
#9
REVIEW
George W Ousler, David Rimmer, Lisa M Smith, Mark B Abelson
The many internal and external factors that contribute to the pathophysiology of dry eye disease (DED) create a difficult milieu for its study and complicate its clinical diagnosis and treatment. The controlled adverse environment (CAE(®)) model has been developed to minimize the variability that arises from exogenous factors and to exacerbate the signs and symptoms of DED by stressing the ocular surface in a safe, standardized, controlled, and reproducible manner. By integrating sensitive, specific, and clinically relevant endpoints, the CAE has proven to be a unique and adaptable model for both identifying study-specific patient populations with modifiable signs and symptoms, and for tailoring the evaluation of interventions in clinical research studies...
December 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28889729/role-of-post-transcriptional-regulation-of-mrna-stability-on-the-expression-of-cytokine-coding-genes-in-renal-inflammation
#10
Eva Feigerlová, Shyue-Fang Battaglia-Hsu
Mechanisms that control mammalian gene expression, notably mRNA stability and translation, have major functions in the modulation of the cellular response to internal and external stimuli. Altered posttranscriptional regulation of gene expression has been associated with many diseases. Such types of deregulation have also recently been noted on the inflammatory cytokines pertinent to kidney inflammation. In this article, we summarize briefly the recent knowledge obtained from both human and experimental systems on the details of posttranscriptional regulation of gene expression related to the control of mRNA stability and discuss their relevance in regulating cytokine expression linked to the inflammatory processes in kidney...
September 8, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28888529/eyelid-inflammation-an-uncommon-cause-in-occidental-countries
#11
Hélène Devambez, Morgane Richeux, Maximilien Guericolas, Christophe Choquet, Enrique Casalino, Aiham Daniel Ghazali
BACKGROUND: Myiasis designates the infestation of live human and vertebrate animals with dipterous (two-winged) larvae (maggots) and is the fourth most common travel-associated skin disease. Furuncle is the most common aspect of cutaneous myiasis. CASE PRESENTATION: A 24-year-old Caucasian female had been back from Cap-Vert. She described pruritus, slight pain, and the sensation of a foreign body moving in the eyelid. Physical examination showed a single furuncle-like nodule with surrounding erythema and a central pore of the upper eyelid through which a serosanguinous fluid was exuding...
November 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28874911/a-ligation-of-the-lacrimal-excretory-duct-in-mouse-induces-lacrimal-gland-inflammation-with-proliferative-cells
#12
Ying Liu, Masatoshi Hirayama, Tetsuya Kawakita, Kazuo Tsubota
The lacrimal gland secretes tear fluids to ocular surface, which plays an indispensable role in maintaining the health of the ocular epithelia and protecting the ocular surface from the external environment. The dysfunction of the lacrimal glands causes dry eye disease due to a reduction in tear volume. The dry eye disease is becoming a popular public disease, for the number of patients is increasing, who have subjective symptom and loss of vision, which affect the quality of life. Inflammatory change in the damaged lacrimal gland has been reported; however, a major challenge is to establish a simple animal model to observe the changes...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28866667/a-modified-technique-for-the-transconjunctival-and-sutureless-external-drainage-of-subretinal-fluid-in-bullous-exudative-retinal-detachment-using-a-24-g-i-v-catheter
#13
Jie Peng, Qi Zhang, Haiying Jin, Ping Fei, Peiquan Zhao
PURPOSE: To present the use of a 24-G Optiva® i.v. catheter for external drainage of subretinal fluid (SRF) in bullous exudative retinal detachment (RD). METHODS: Thirteen eyes with bullous exudative RD were included in our study. SRF drainage was accomplished via a transconjunctival scleral incision with a 24-G catheter followed by laser treatment, vitrectomy, or anti-VEGF treatment, as needed. Data on age, indications, visual acuities, the number of drainage times, drainage duration, complications, and fundoscopy were collected...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28861359/intraocular-lymphoma
#14
REVIEW
Li-Juan Tang, Chang-Lin Gu, Ping Zhang
Intraocular lymphoma (IOL) is a rare lymphocytic malignancy which contains two main distinct forms. Primary intraocular lymphoma (PIOL) is mainly a sub-type of primary central nervous system lymphoma (PCNSL). Alternatively, IOL can originate from outside the central nervous system (CNS) by metastasizing to the eye. These tumors are known as secondary intraocular lymphoma (SIOL). The IOL can arise in the retina, uvea, vitreous, Bruch's membrane and optic nerve. There are predominantly of B-cell origin; however there are also rare T-cell variants...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28820791/teleophthalmic-approach-for-detection-of-corneal-diseases-accuracy-and-reliability
#15
Maria A Woodward, David C Musch, Christopher T Hood, Jonathan B Greene, Leslie M Niziol, V Swetha E Jeganathan, Paul P Lee
PURPOSE: Corneal and anterior segment diseases cause most of the urgent visits to eye care professionals. We evaluated the diagnostic accuracy of detecting corneal diseases using external photographs from 2 portable cameras for telemedicine purposes. METHODS: This is a prospective study of adults with a clinical diagnosis of corneal pathology including corneal abrasions, ulcers, scars, and pterygia. A cornea specialist provided the gold standard diagnosis by slit-lamp examination...
October 2017: Cornea
https://www.readbyqxmd.com/read/28781219/a-randomized-controlled-study-of-art-observation-training-to-improve-medical-student-ophthalmology-skills
#16
Jaclyn Gurwin, Karen E Revere, Suzannah Niepold, Barbara Bassett, Rebecca Mitchell, Stephanie Davidson, Horace DeLisser, Gil Binenbaum
PURPOSE: Observation and description are critical to the practice of medicine, and to ophthalmology in particular. However, medical education does not provide explicit training in these areas, and medical students are often criticized for deficiencies in these skills. We sought to evaluate the effects of formal observation training in the visual arts on the general and ophthalmologic observational skills of medical students. DESIGN: Randomized, single-masked, controlled trial...
August 3, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28749895/mechanical-modeling-of-a-keratoconic-cornea
#17
Jean Marc Perone, Jean Baptiste Conart, Pierre-Jean Bertaux, Nicolas Sujet-Perone, Nadia Ouamara, Maxime Sot, Jean Jacques Henry
PURPOSE: We created a laboratory model of a cornea that was subjected to various pressures and thermal and mechanical factors to better understand the genesis of keratoconus deformation. METHODS: A steel base allowed for fixation of circular multilaminated patches of araldite (10 cm in diameter, 5 mm thick) in which the corneal anatomy was modeled. The model was plunged into a steam room (374°F/3 bars of pressure for 1 h) to ensure thermal homogeneity and was subjected to pressure using compressed air...
October 2017: Cornea
https://www.readbyqxmd.com/read/28739193/intraocular-metastasis-comparison-of-clinical-presentation-with-a-known-and-unknown-primary-tumour
#18
R Ramoa, M A Saornil, C García-Alvarez, P Diezhandino, P Alonso-Martínez, E García-Lagarto, M F Muñoz-Moreno, F Lopez-Lara
OBJECTIVE: The purpose of the present study is to review the frequency of intraocular metastases as first presentation of systemic disease, and to identify clinical and tumour characteristics. METHODS: Retrospective study of consecutive cases diagnosed of intraocular metástasis at a referral intraocular tumours unit between 1993 and 2014. General, epidemiological and ophthalmological characteristics were recorded. RESULTS: A total of 21 patients, with a mean age 62...
July 21, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28695744/genome-editing-the-breakthrough-technology-for-inherited-retinal-disease
#19
Andrew J Smith, Stephen P Carter, Breandán N Kennedy
Genetic alterations resulting in a dysfunctional retinal pigment epithelium and/or degenerating photoreceptors cause impaired vision. These juxtaposed cells in the retina of the posterior eye are crucial for the visual cycle or phototransduction. Deficits in these biochemical processes perturb neural processing of images capturing the external environment. Notably, there is a distinct lack of clinically approved pharmacological, cell- or gene-based therapies for inherited retinal disease. Gene editing technologies are rapidly advancing as a realistic therapeutic option...
July 11, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28623239/-ccug-n-rna-toxicity-in-a-drosophila-model-of-myotonic-dystrophy-type-2-dm2-activates-apoptosis
#20
Vildan Betul Yenigun, Mario Sirito, Alla Amcheslavky, Tomek Czernuszewicz, Jordi Colonques-Bellmunt, Irma García-Alcover, Marzena Wojciechowska, Clare Bolduc, Zhihong Chen, Arturo López Castel, Ralf Krahe, Andreas Bergmann
The myotonic dystrophies are prototypic toxic RNA gain-of-function diseases. Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are caused by different unstable, noncoding microsatellite repeat expansions - (CTG)DM1 in DMPK and (CCTG)DM2 in CNBP Although transcription of mutant repeats into (CUG)DM1 or (CCUG)DM2 appears to be necessary and sufficient to cause disease, their pathomechanisms remain incompletely understood. To study the mechanisms of (CCUG)DM2 toxicity and develop a convenient model for drug screening, we generated a transgenic DM2 model in the fruit fly Drosophila melanogaster with (CCUG)n repeats of variable length (n=16 and 106)...
August 1, 2017: Disease Models & Mechanisms
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