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https://www.readbyqxmd.com/read/29448286/-mitochondrial-dysfunctions-and-role-of-coenzyme-q10-in-patients-with-glaucoma
#1
Carl Erb, Katarzyna Konieczka
Mitochondrial function is closely linked to numerous aspects of eye health. Imbalance between the creation of energy and the development of reactive oxygen species (ROS) seems to be the cause of the development of mitochondrial dysfunctions. As a result of this energy deficit, the level of oxidative stress in the eye tissues increases, leading to numerous ophthalmic impairments. It is important to distinguish between primary mitochondrial eye diseases and secondary mitochondrial changes. Primary mitochondrial eye diseases, for example Leber's hereditary optic atrophy (LHON), retinitis pigmentosa and chronic progressive external ophthalmoplegia are caused by direct damage to mitochondrial function induced by defective genes, either located on mitochondrial DNA (mtDNA) or the DNA of the nucleus (nDNA)...
February 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29390029/the-effects-of-anxiety-and-external-attentional-focus-on-postural-control-in-patients-with-parkinson-s-disease
#2
Seyede Zohreh Jazaeri, Akram Azad, Hajar Mehdizadeh, Seyed Amirhassan Habibi, Mahbubeh Mandehgary Najafabadi, Zakieh Sadat Saberi, Hawre Rahimzadegan, Saeed Moradi, Saeed Behzadipour, Mohamad Parnianpour, Ghorban Taghizadeh, Kinda Khalaf
BACKGROUND: Although anxiety is a common non-motor outcome of Parkinson's disease (PD) affecting 40% of patients, little attention has been paid so far to its effects on balance impairment and postural control. Improvement of postural control through focusing on the environment (i.e. external focus) has been reported, but the role of anxiety, as a confounding variable, remains unclear. OBJECTIVES: This study aimed to investigate the influence of anxiety and attentional focus instruction on the standing postural control of PD patients...
2018: PloS One
https://www.readbyqxmd.com/read/29382496/-orbital-cellulitis-complicated-by-subperiosteal-abscess-due-to-streptococcus-pyogenes-infection
#3
José Daniel Ruíz Carrillo, Edwin Vázquez Guerrero, Mónica Cecilia Mercado Uribe
BACKGROUND: Orbital cellulitis is an infectious disease that is very common in pediatric patients, in which severe complications may develop. Etiological agents related to this disease are Haemophilus influenzae B, Staphylococcus aureus, Streptococcus pneumoniae and Moraxella catarrhalis, which correspond to 95% of cases. Moreover, Streptococcus beta hemolytic and anaerobic microorganisms may also be present corresponding to < 5% of the cases. We present an uncommon case of cellulitis complicated by sub-periosteal abscess caused by Streptococcus pyogenes (Group A beta hemolytic streptococcus)...
March 2017: Boletín Médico del Hospital Infantil de México
https://www.readbyqxmd.com/read/29380758/clinical-signs-in-cornea-and-ocular-surface
#4
REVIEW
C Banu Cosar, Mittanamalli S Sridhar
A careful examination of cornea and ocular surface eliciting the basic signs will help a clinician toward an accurate diagnosis. Flipping the upper lid or pulling the lower lid to look at the inferior fornix may help to pick up any subtle clinical sign. Meticulous documentation by diffuse and slit view will help in following up the disease. Eyelids and ocular surface are evaluated externally and by slit lamp. Slit-lamp examination with the use of the stains such as fluorescein, rose bengal, or lissamine green provides extensive knowledge about the ocular surface...
February 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29361355/long-term-outcomes-of-total-exudative-retinal-detachments-in-stage-3b-coats-disease
#5
Albert S Li, Antonio Capone, Michael T Trese, Jonathan E Sears, Andres Kychenthal, Irina De la Huerta, Philip J Ferrone
PURPOSE: To evaluate the long-term outcomes of treatment of total exudative retinal detachments (ERDs) secondary to Coats disease (stage 3B) and the role of vitrectomy. DESIGN: Retrospective, observational case series. PARTICIPANTS: A total of 16 eyes in 16 patients undergoing treatment for total ERDs secondary to Coats disease with at least 5 years of follow-up. METHODS: We reviewed the records of patients with stage 3B Coats disease...
January 17, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29352993/comparison-of-chorioretinal-layers-in-rhesus-macaques-using-spectral-domain-optical-coherence-tomography-and-high-resolution-histological-sections
#6
Glenn Yiu, Zhe Wang, Christian Munevar, Eric Tieu, Bradley Shibata, Brittany Wong, David Cunefare, Sina Farsiu, Jeffrey Roberts, Sara Thomasy
Nonhuman primates are important preclinical models of retinal diseases because they uniquely possess a macula similar to humans. Ocular imaging technologies such as spectral-domain optical coherence tomography (SD-OCT) allow noninvasive, in vivo measurements of chorioretinal layers with near-histological resolution. However, the boundaries are based on differences in reflectivity, and detailed correlations with histological tissue layers have not been explored in rhesus macaques, which are widely used for biomedical research...
January 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29348987/rhino-orbital-cerebral-mucormycosis-a-fatal-complication-of-uncontrolled-diabetes-mellitus
#7
Purva Bavikar, Varshil Mehta
Mucormycosis is a progressively invasive disease, with a fatal outcome, on late presentation. A 38-year-old female presented with diabetic ketoacidosis with right eye ptosis and a frozen globe without any signs of inflammation, externally. She underwent transnasal endoscopic debridement of paranasal sinuses and exenteration of the right eye. The histopathology specimen revealed the growth of mucormycosis. She was treated with intravenous (IV) amphotericin B, IV insulin, and extensive debridement surgery, but had an unfavorable outcome due to rapid mucor invasion to the brain...
November 13, 2017: Curēus
https://www.readbyqxmd.com/read/29327033/disorganization-of-inner-retina-and-outer-retinal-morphology-in-diabetic-macular-edema
#8
Radha Das, Gareth Spence, Ruth E Hogg, Michael Stevenson, Usha Chakravarthy
Importance: In diabetic macular edema (DME), identification of baseline markers on spectral-domain optical coherence tomography (SD-OCT) and their association with severity of diabetic retinopathy (DR) might aid in disease management and the design of future trials. Objective: To examine associations between DR severity, retinal morphology on SD-OCT, and visual acuity in participants with DME. Design, Setting, and Participants: This cross-sectional observational case series was conducted at a single tertiary care referral center...
January 11, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29306863/implementation-of-medical-retina-virtual-clinics-in-a-tertiary-eye-care-referral-centre
#9
Karsten Kortuem, Katrin Fasler, Amanda Charnley, Hussain Khambati, Sandro Fasolo, Menachem Katz, Konstantinos Balaskas, Ranjan Rajendram, Robin Hamilton, Pearse A Keane, Dawn A Sim
BACKGROUND: The increasing incidence of medical retinal diseases has created capacity issues across UK. In this study, we describe the implementation and outcomes of virtual medical retina clinics (VMRCs) at Moorfields Eye Hospital, South Division, London. It represents a promising solution to ensure that patients are seen and treated in a timely fashion METHODS: First attendances in the VMRC (September 2016-May 2017) were included. It was open to non-urgent external referrals and to existing patients in a face-to-face clinic (F2FC)...
January 6, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29285067/morphologic-characteristics-and-clinical-significance-of-the-macular-sparing-area-in-patients-with-retinitis-pigmentosa-as-revealed-by-multicolor-imaging
#10
Guodong Liu, Qing Du, Khusbu Keyal, Fang Wang
Retinitis pigmentosa (RP) is an inherited retinal disease caused by the degeneration of photoreceptors and retinal pigment epithelium cells within the eye. The present study aimed to evaluate the effectiveness of multicolor imaging as a novel technique for the depiction of morphological features in the macular area of patients with RP. Additionally, the correlation between the size of the macular-sparing area and the best corrected visual acuity (BCVA), central visual field function and subfoveal choroidal thickness (SFCT) was analyzed...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29232760/the-association-of-keratoconus-with-blepharitis
#11
Dina Mostovoy, Shlomo Vinker, Michael Mimouni, Yakov Goldich, Shmuel Levartovsky, Igor Kaiserman
BACKGROUND: Identifying potentially treatable risk factors for the progression of keratoconus is of great importance. The purpose of this study was to determine the association between blepharitis and keratoconus. METHODS: In this prospective, comparative, observational study, 50 keratoconus participants from the central district of the Clalit Health Services Health Maintenance Organization in Israel underwent comprehensive eye examination. Seventy-two healthy medical personnel of similar ages were randomly chosen as a control group...
December 12, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29121219/clinicopathological-features-of-ocular-adnexal-mantle-cell-lymphoma-in-an-international-multicenter-cohort
#12
Marina K H Knudsen, Peter K Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Jwu Jin Khong, Penny A McKelvie, Kaustubh Mulay, Elisabeth Ralfkiaer, Lene D Sjö, Geeta K Vemuganti, Bradley A Thuro, Jeremy Curtin, Steffen Heegaard
Importance: To our knowledge, the clinical features of ocular adnexal mantle-cell lymphoma (OA-MCL) have not previously been evaluated in a large multicenter cohort. Objective: To characterize the clinical features of OA-MCL. Design, Setting, and Participants: This retrospective multicenter study included patient data collected from January 1, 1980, through December 31, 2015, at 6 eye cancer centers in 4 countries. Medical records of 55 patients with OA-MCL were reviewed; the median length of follow-up was 33 months...
November 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29108394/comparative-study-of-3-exophthalmometers-and-computed-tomographic-biometry
#13
Juliette Delmas, Jean-Marie Loustau, Sylvain Martin, Loïc Bourmault, Jean-Paul Adenis, Pierre-Yves Robert
PURPOSE: Accurate and reproducible exophthalmometry is mandatory to diagnose and follow-up orbital patients, especially in Graves disease. However, many variations are described among the different commercially available exophthalmometers. METHODS: Sixty patients, who underwent a cerebral computed tomography (CT) scan, were included. External prebicanthal segments (EPBCS) for right and left eyes (RE and LE), interorbital distance, and globe axial length were recorded by a first observer (O1), more experienced than a second (O2)...
November 2, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29101007/epidemiology-of-primary-ophthalmic-inpatient-admissions-in-the-united-states
#14
Mustafa Iftikhar, Nadia Junaid, Marili Lemus, Zyannah N Mallick, Syeda A Mina, Urooba Hannan, Joseph K Canner, Asad Latif, Syed Mahmood Ali Shah
PURPOSE: To determine the national estimates, demographics, and costs of inpatient eye care in the United States (US). DESIGN: Retrospective cross-sectional study. METHODS: National Inpatient Sample (NIS), a representative sample of all US community hospitals, was used to analyze inpatient admissions with a primary ophthalmic diagnosis from 2001 to 2014. National estimates of the most prevalent diagnoses were determined, and descriptive statistics were calculated for demographics and costs...
January 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29064950/epidemiology-of-reduced-visual-acuity-among-chinese-multiethnic-students
#15
Deng-Juan Qian, Min Hu, Hua Zhong, Qiao Nie, Jun Li, Yuansheng Yuan, Chen-Wei Pan
SIGNIFICANCE: Data regarding the epidemiology of reduced visual acuity (VA) among multiethnic children and adolescents in China are few. Understanding the vision-related health inequalities among different ethnic groups is crucial for health resource allocations and clinical managements for eye diseases. PURPOSE: We aim to determine the prevalence, main causes, and health inequalities of reduced VA in multiethnic school students in rural China. METHODS: A school-based eye survey including 7681 multiethnic school students aged 5 to 16 years in the southwestern part of China was conducted...
December 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29053974/depression-as-seen-through-the-eyes-of-rural-chinese-women-implications-for-help-seeking-and-the-future-of-mental-health-care-in-china
#16
Peiyuan Qiu, Eric D Caine, Fengsu Hou, Catherine Cerulli, Marsha N Wittink
BACKGROUND: As part of a larger epidemiological study of depression among rural Chinese women, we sought to understand their explanatory models of depression. We explored how participants describe depression, to what cause they attribute depression, and what sources of treatment they would recommend. METHODS: Participants first were assessed with the Center for Epidemiological-Depression scale (CES-D), with a cut-point of 16 or greater indicative of depression. The Short Explanatory Model Interview (SEMI), a semi-structured questionnaire, was our primary tool for exploring participants' explanatory models relating to a vignette describing a rural Chinese woman with depression...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053687/bead-based-multiplex-assay-for-analysis-of-tear-cytokine-profiles
#17
Praveen Kumar Balne, Veonice Bijin Au, Louis Tong, Arkasubhra Ghosh, Mukesh Agrawal, John Connolly, Rupesh Agrawal
Tear film is a complex mixture of lipids, proteins and minerals which covers the external surface of the eye, thereby providing lubrication, nutrition and protection to the underlying cells. Analysis of tears is an emerging area for the identification of biomarkers for the prediction, diagnosis, and prognosis of various ocular diseases. Tears are easily accessible and their collection is non-invasive. Therefore, advancing technologies are gaining prominence for identification of multiple analytes in tears to study changes in protein or metabolite composition and its association with pathological conditions...
October 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29037595/cellular-characterization-of-optical-coherence-tomography-and-outer-retinal-bands-using-specific-immunohistochemistry-markers-and-clinical-implications
#18
Nicolás Cuenca, Isabel Ortuño-Lizarán, Isabel Pinilla
PURPOSE: Optical coherence tomography has been a technological breakthrough in the diagnosis, treatment, and follow-up of many ocular diseases, especially retinal and neuro-ophthalmologic pathologic conditions. Until now, several controversies have arisen over the specific cell types that the bands observed in the OCT represent, especially over the 4 outer retinal bands. DESIGN: To correlate the 4 outer hyperreflective bands observed in the OCT with the histologic structures using human retinal sections and immunocytochemistry at the fovea level...
October 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29018015/chronic-red-eye-a-masquerade-of-advanced-neoplastic-disease
#19
Joana Providência, Filipa Ponces, Guilherme Castela, Joaquim Murta
A 42-year-old woman presented with chronic history of left red eye for more than 12 months, treated with difference topical medication but without response. Ocular external examination demonstrated a firm palpable mass in the medial portion of the lower eyelid and slit-lamp evaluation of the lesion showed an ulcerated conjunctival nodule, keratin secretor. CT of the orbits revealed left-sided orbital mass located anteriorly, inferiorly and medially in the orbit, adjacent to the globe and orbit walls. Incisional biopsy of the lesion was consistent with invasive squamous cell carcinoma of the conjunctiva...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28956287/use-of-the-controlled-adverse-environment-cae-in-clinical-research-a-review
#20
REVIEW
George W Ousler, David Rimmer, Lisa M Smith, Mark B Abelson
The many internal and external factors that contribute to the pathophysiology of dry eye disease (DED) create a difficult milieu for its study and complicate its clinical diagnosis and treatment. The controlled adverse environment (CAE(®)) model has been developed to minimize the variability that arises from exogenous factors and to exacerbate the signs and symptoms of DED by stressing the ocular surface in a safe, standardized, controlled, and reproducible manner. By integrating sensitive, specific, and clinically relevant endpoints, the CAE has proven to be a unique and adaptable model for both identifying study-specific patient populations with modifiable signs and symptoms, and for tailoring the evaluation of interventions in clinical research studies...
December 2017: Ophthalmology and Therapy
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