Julie R Palmer, Eric C Polley, Chunling Hu, Esther M John, Christopher Haiman, Steven N Hart, Mia Gaudet, Tuya Pal, Hoda Anton-Culver, Amy Trentham-Dietz, Leslie Bernstein, Christine B Ambrosone, Elisa V Bandera, Kimberly A Bertrand, Traci N Bethea, Chi Gao, Rohan D Gnanaolivu, Hongyan Huang, Kun Y Lee, Loic LeMarchand, Jie Na, Dale P Sandler, Payal D Shah, Siddhartha Yadav, William Yang, Jeffrey N Weitzel, Susan M Domchek, David E Goldgar, Katherine L Nathanson, Peter Kraft, Fergus J Couch
BACKGROUND: The risks of breast cancer in African American (AA) women associated with inherited mutations in breast cancer predisposition genes are not well defined. Thus, whether multigene germline hereditary cancer testing panels are applicable to this population is unknown. We assessed associations between mutations in panel-based genes and breast cancer risk in 5054 AA women with breast cancer and 4993 unaffected AA women drawn from 10 epidemiologic studies. METHODS: Germline DNA samples were sequenced for mutations in 23 cancer predisposition genes using a QIAseq multiplex amplicon panel...
May 19, 2020: Journal of the National Cancer Institute