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https://www.readbyqxmd.com/read/29334672/oxidative-and-interactive-challenge-of-cadmium-and-ocean-acidification-on-the-smooth-scallop-flexopecten-glaber
#1
Alessandro Nardi, Maura Benedetti, Daniele Fattorini, Francesco Regoli
Ocean acidification (OA) may affect sensitivity of marine organisms to metal pollution modulating chemical bioavailability, bioaccumulation and biological responsiveness of several cellular pathways. In this study, the smooth scallop Flexopecten glaber was exposed to various combinations of reduced pH (pH/pCO2 7.4/∼3000 μatm) and Cd (20 μg/L). The analyses on cadmium uptake were integrated with those of a wide battery of biomarkers including metallothioneins, single antioxidant defenses and total oxyradical scavenging capacity in digestive gland and gills, lysosomal membrane stability and onset of genotoxic damage in haemocytes...
January 8, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29334663/acute-toxicity-screening-of-different-extractions-components-and-constituents-of-polygonum-multiflorum-thunb-on-zebrafish-danio-rerio-embryos-in-vivo
#2
Jian-Bo Yang, Wan-Fang Li, Yue Liu, Qi Wang, Xian-Long Cheng, Feng Wei, Ai-Guo Wang, Hong-Tao Jin, Shuang-Cheng Ma
Polygonum multiflorum Thunb. has been used widely in East Asia in treatment of diseases associated with aging. However, there are many reports referred to the toxicity of P. multiflorum, especially for liver adverse reactions. The toxicity of it is caused by over dosage or by the herb itself remains unclear. The aim of this study was to study the toxicity of different extractions, components and constituents of P. multiflorum, which were assessed in zebrafish embryos. Firstly, the difference of extracting solvent to the toxicity of P...
January 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29334650/environmentally-relevant-concentrations-of-glibenclamide-induce-oxidative-stress-in-common-carp-cyprinus-carpio
#3
Ericka María Guadalupe Martínez-Viveros, Hariz Islas-Flores, Octavio Dublán-García, Marcela Galar-Martínez, Nely SanJuan-Reyes, Sandra García-Medina, María Dolores Hernández-Navarro, Leobardo Manuel Gómez-Oliván
The hypoglycemic pharmaceutical glibenclamide (GLB) is widely used around the world. This medication is released into the environment by municipal, hospital and industrial wastewater discharges. Although there are reports of its environmental occurrence in the scientific literature, toxicity studies on aquatic species of commercial interest such as the common carp Cyprinus carpio are scarce. The present study aimed to evaluate the oxidative stress induced on C. carpio by environmentally relevant concentrations of GLB...
January 12, 2018: Chemosphere
https://www.readbyqxmd.com/read/29334610/phase-ii-study-of-dovitinib-in-patients-with-castration-resistant-prostate-cancer-kcsg-gu11-05
#4
Yoon Ji Choi, Hye Sook Kim, Se Hoon Park, Bong-Seog Kim, Kyoung Ha Kim, Hyo Jin Lee, Hong Suk Song, Dong-Yeop Shin, Ha Young Lee, Hoon-Gu Kim, Kyung Hee Lee, Jae Lyun Lee, Kyong Hwa Park
Purpose: Fibroblast growth factor (FGF) signals are important in carcinogenesis and progression of prostate cancer. Dovitinib is an oral, pan-class inhibitor of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor, and fibroblast growth factor receptor (FGFR). We evaluated the efficacy and toxicity of dovitinib in men with metastatic castration resistant prostate cancer (mCRPC). Materials and Methods: This study was a single-arm, phase II, open-label, multicenter trial of dovitinib 500mg/day (5-days-on/2-days-off schedule)...
January 2, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29334605/induction-chemotherapy-plus-concurrent-chemoradiotherapy-versus-concurrent-chemoradiotherapy-alone-in-locoregionally-advanced-nasopharyngeal-carcinoma-in-children-and-adolescents-a-matched-cohort-analysis
#5
Yang Li, Lin-Quan Tang, Li-Ting Liu, Shan-Shan Guo, Yu-Jing Liang, Xue-Song Sun, Qing-Nan Tang, Jin-Xin Bei, Jing Tan, Shuai Chen, Jun Ma, Chong Zhao, Qiu-Yan Chen, Hai-Qiang Mai
Purpose: The purpose of this study was to evaluate the long-term clinical outcome and toxicity of induction chemotherapy (IC) followed by concomitant chemoradiotherapy (CCRT) compared with CCRT alone for the treatment of children and adolescent locoregionally advanced nasopharyngeal carcinoma (LACANPC). Patients and Methods: A total of 194 locoregionally advanced NPC patients younger than 21 years who received CCRT with or without IC before were included in the study population...
January 8, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29334534/symptomatic-hyperammonemia-with-erwinia-chrysanthemi-derived-asparaginase-in-pediatric-leukemia-patients
#6
Nathan Gossai, Michael Richards, Lara Boman, Yoav Messinger, Sara Gernbacher, Joanna Perkins, Bruce Bostrom
Erwinia chrysanthemi-derived asparaginase is increasingly integral to acute lymphoblastic leukemia therapy. In our series, 16% of patients developed symptomatic hyperammonemia following Erwinia administration with symptoms including refractory nausea, vomiting, profound fatigue, malaise, and coma. This series of patients receiving Erwinia indicates higher than expected incidence of hyperammonemia, correlation between ammonia and asparaginase levels and therapeutic asparaginase activity levels despite dose reduction...
January 12, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29334465/design-of-mini-nucleic-acid-probe-for-cooperative-binding-of-rna-repeated-transcript-associated-with-myotonic-dystrophy-type-1
#7
Wei-Che Hsieh, Raman Bahal, Shivaji Thadke, Kirti Bhatt, Krzysztof Sobczak, Charles A Thornton, Danith H Ly
Toxic RNAs containing expanded trinucleotide repeats are the cause of many neuromuscular disorders, one being myotonic dystrophy type 1 (DM1). DM1 is triggered by CTG-repeat expansion in the 3'-UTR of the DMPK gene, resulting in toxic-gain of RNA function through sequestration of MBNL1 protein, among others. Herein we report the development of a relatively short MPPNA probe, two triplet-repeats in length, containing terminal pyrene moieties, that is capable of binding rCUG-repeats in a sequence-specific and selective manner...
January 15, 2018: Biochemistry
https://www.readbyqxmd.com/read/29334441/statin-pharmacogenetics-moving-from-toxicity-to-efficacy
#8
Eric A Larson
No abstract text is available yet for this article.
December 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29334419/a-metallo-pro-drug-to-target-cu-ii-in-the-context-of-alzheimer-s-disease
#9
Amandine Conte-Daban, Vinita Ambike, Régis Guillot, Nicolas Delsuc, Clotilde Policar, Christelle Hureau
Alzheimer's disease and oxidative stress are connected. In the present communication, we report the use of a Mn(II)-based superoxide dismutase mimic ([MnII(L)]+, 1+) as a pro-drug candidate to target Cu(II) associated events, i.e. Cu(II)-induced formation of reactive oxygen species (ROS) and modulation of the amyloid-beta (Abeta) peptide aggregation. Complex 1+ is able to remove Cu(II) from Abeta, stop ROS and prevent alteration of Abeta aggregation as would do the corresponding free ligand LH. Using 1+ instead of LH in further biological applications would have the double advantage to avoid the cell toxicity of LH and to benefit from its proved SOD-like activity...
January 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29334400/oolong-tea-and-lr-white-resin-a-new-method-of-plant-sample-preparation-for-transmission-electron-microscopy
#10
Xiaohua He, Fuzhen Guo, Bin Liu
Simplifying sample processing, shortening the sample preparation time, and adjusting procedures to suitable for new health and safety regulations, these issues are the current challenges which electron microscopic examinations need to face. In order to resolve these problems, new plant tissue sample processing protocols for transmission electron microscopy should be developed. In the present study, we chose the LR-White resin-assisted processing protocol for the ultrastructural observation of different types of plant tissues...
January 15, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29334393/facile-fabrication-and-characterization-of-two-dimensional-bismuth-iii-sulfide-nanosheets-for-high-performance-photodetector-applications-under-ambient-conditions
#11
Weichun Huang, Chenyang Xing, Yunzheng Wang, Zhongjun Li, Leiming Wu, Dingtao Ma, Xiaoyu Dai, Yuanjiang Xiang, Jianqing Li, Dianyuan Fan, Han Zhang
Two-dimensional (2D) bismuth(iii) sulfide (Bi2S3) nanosheets as non-toxic graphene-like nanomaterials were successfully fabricated by a facile liquid phase exfoliation (LPE) method. A robust photodetector employing a Bi2S3 nanosheet film has been fabricated for the first time via a facile fabrication process on an ITO-coated glass. UV-Vis and Raman spectroscopy techniques were carried out and they confirmed the inherent optical and physical properties of Bi2S3 nanosheets. Photoelectrochemical (PEC) measurements demonstrate that a significantly higher photocurrent density (42 μA cm-2) and enhanced photoresponsivity (210 μA W-1), at a lower bias potential in alkaline solution, of the Bi2S3 nanosheet-based photodetector are achieved, compared with those of other 2D nanomaterial-based photodetectors under light irradiation...
January 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29334340/identification-of-anti-filarial-leads-against-aspartate-semialdehyde-dehydrogenase-of-wolbachia-endosymbiont-of-brugia-malayi-combined-molecular-docking-and-molecular-dynamics-approaches
#12
Dhamodharan Prabhu, Sundaraj Rajamanikandan, Mathimaran Amala, Surekha Kanagarajan, Jeyaraman Jeyakanthan
Lymphatic filariasis is a debilitating vector borne parasitic disease that infects human lymphatic system by nematode Brugia malayi. Currently available anti-filarial drugs are effective only on the larval stages of parasite. So far, no effective drugs are available for humans to treat filarial infections. In this regard, aspartate semialdehyde dehydrogenase (ASDase) in lysine biosynthetic pathway from Wolbachia endosymbiont Brugia malayi represents an attractive therapeutic target for the development of novel anti-filarial agents...
January 15, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29334260/crude-extract-of-origanum-vulgare-l-induced-cell-death-and-suppressed-mapk-and-pi3-akt-signaling-pathways-in-sw13-and-h295r-cell-lines
#13
Beatrice Rubin, Jacopo Mansi, Halenya Monticelli, Loris Bertazza, Marco Redaelli, Francesca Sensi, Maira Zorzan, Carla Scaroni, Caterina Mian, Maurizio Iacobone, Decio Armanini, Cristina Bertolini, Susi Barollo, Marco Boscaro, Raffaele Pezzani
Oregano (Origanum vulgare L.) is a common aromatic plant used in Mediterranean and Asian Regions for treating respiratory diseases, painful menstruation, rheumatoid arthritis, etc. Recently its role as an anticancer plant has been suggested, although oregano has been never evaluated into adrenocortical tumour cell models. This study analysed for the first time the anticancer effects of a crude extract of wild mountain oregano (Origanum vulgare L.) in SW13 and H295R cell lines. The crude extract was characterised by GC/MS and the toxic effects of oregano were first analysed by brine shrimp lethality assay...
January 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29334247/development-of-fisetin-loaded-folate-functionalized-pluronic-micelles-for-breast-cancer-targeting
#14
Atmaram Pawar, Srishti Singh, S Rajalakshmi, Karimunnisa Shaikh, C Bothiraja
The natural flavonoid fisetin (FS) has shown anticancer properties but its in-vivo administration remains challenging due to its poor aqueous solubility. The aim of the study was to develop FS loaded pluronic127 (PF)-folic acid (FA) conjugated micelles (FS-PF-FA) by the way of increasing solubility, bioavailability and active targetability of FS shall increase its therapeutic efficacy. FA-conjugated PF was prepared by carbodiimide crosslinker chemistry. FS-PF-FA micelles were prepared by thin-film hydration method and evaluated in comparison with free FS and FS loaded PF micelles (FS-PF)...
January 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29334216/lysosome-independent-intracellular-drug-gene-co-delivery-by-lipoprotein-derived-nanovector-for-synergistic-apoptosis-inducing-cancer-targeted-therapy
#15
Wei Wang, Kerong Chen, Yujie Su, Jielei Zhang, Min Li, Jianping Zhou
In this paper, reconstituted high-density lipoprotein (rHDL), a lipoprotein-derived nanovector, were constructed for co-delivery of paclitaxel (PTX) and wild type p53 gene (p53). The particle size and the zeta potential of PTX-DODAB/p53-rHDL nanoparticles were 177.2 nm and -20.06 mV, respectively. Meanwhile, they exhibited great serum stability and satisfactory sustained release characteristics in vitro. PTX-DODAB/pDNA-rHDL nanoparticles simultaneously improved the cellular uptake of PTX and pDNA via scavenger receptor B type I (SR-BI) mediated lysosome-independent internalization and promoted the transfection of pDNA in MCF-7 cells, which were revealed by flow cytometry and confocal laser scanning microscopy analyses...
January 15, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29334211/curcumin-and-quercetin-ameliorated-cypermethrin-and-deltamethrin-induced-reproductive-system-impairment-in-male-wistar-rats-by-upregulating-the-activity-of-pituitary-gonadal-hormones-and-steroidogenic-enzymes
#16
Poonam Sharma, Irshad Aslam Khan, Rambir Singh
Background: Dietary antioxidants protect tissues and organs against insecticides/xenobiotic-induced damage. In the present study, we evaluated the results of exposure to synthetic pyrethroid insecticides, cypermethrin (Cyp) and deltamethrin (Del) and possible protective effects of curcumin and quercetin on reproductive system in male Wistar rats. MATERIALS AND METHODS: In this controlled experimental study, 42 male Wistar rats were randomly divided into 7 groups of 6 animals...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29334186/natural-humic-acid-based-phototheranostic-agent
#17
Zhao-Hua Miao, Kai Li, Pei-Ying Liu, Zhenglin Li, Huanjie Yang, Qingliang Zhao, Manli Chang, Qingzhu Yang, Liang Zhen, Cheng-Yan Xu
Humic acids, a major constituent of natural organic carbon resources, are naturally formed through the microbial biodegradation of animal and plant residues. Due to numerous physiologically active groups (phenol, carboxyl, and quinone), the biomedical applications of humic acid have been already investigated across different cultures for several centuries or even longer. In this work, sodium humate, the sodium salt of humic acid, is explored as phototheranostic agent for light-induced photoacoustic imaging and photothermal therapy based on intrinsic absorption in the near-infrared region...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29334180/nitric-oxide-dependent-degradation-of-polyethylene-glycol-modified-single-walled-carbon-nanotubes-implications-for-intra-articular-delivery
#18
Kunal Bhattacharya, Cristiano Sacchetti, Pedro M Costa, Jens Sommertune, Birgit D Brandner, Andrea Magrini, Nicola Rosato, Nunzio Bottini, Massimo Bottini, Bengt Fadeel
Polyethylene glycol (PEG)-modified carbon nanotubes have been successfully employed for intra-articular delivery in mice without systemic or local toxicity. However, the fate of the delivery system itself remains to be understood. In this study 2 kDa PEG-modified single-walled carbon nanotubes (PNTs) are synthesized, and trafficking and degradation following intra-articular injection into the knee-joint of healthy mice are studied. Using confocal Raman microspectroscopy, PNTs can be imaged in the knee-joint and are found to either egress from the synovial cavity or undergo biodegradation over a period of 3 weeks...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29334159/a-gold-iii-pincer-ligand-scaffold-for-the-synthesis-of-binuclear-and-bioconjugated-complexes-synthesis-and-anticancer-potential
#19
Bertrand Benoît, Maria A O'Connell, Zöe A E Waller, Manfred Bochmann
Cyclometalated (C^N^C)Au(III) complexes bearing functionalized N-heterocyclic carbene (NHC) ligands provide a high-yielding, modular route to bioconjugated and binuclear complexes. That methodology has been applied to the synthesis of bioconjugated complexes presenting biotin and 17α-ethynylestradiol vectors, as well as to the synthesis of bimetallic Au(III)/Au(I) complexes. The in vitro antiproliferative activities of these compounds against various cancer cells lines depend on the linker length, with the longer linker being the most potent...
January 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29334126/methylated-pacs-are-more-potent-than-their-parent-compounds-a-study-on-ahr-mediated-activity-degradability-and-mixture-interactions-in-the-h4iie-luc-assay
#20
Monika M Lam, Rebecca Bülow, Magnus Engwall, John P Giesy, Maria Larsson
In this study, 26 polycyclic aromatic compounds (PACs) including native polycyclic aromatic hydrocarbons (PAHs), hydroxylated PAHs, alkylated and oxygenated PAHs and (alkylated) heterocyclic compounds were investigated for their aryl hydrocarbon receptor (AhR)-mediated potencies in the H4IIE-luc bioassay. Potential degradabilities of PACs were investigated by use of various durations of exposure (24, 48 or 72 h). Furthermore, various mixtures of PACs including PAHs, alkylated and oxygenated PAHs and heterocyclic compounds were tested for their joint AhR-mediated potency...
January 15, 2018: Environmental Toxicology and Chemistry
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