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https://www.readbyqxmd.com/read/28545269/-risk-factors-of-endometriosis-associated-ovarian-carcinoma-in-women-aged-45-years-and-older
#1
Z X He, S Wang, Z F Li, L Zhu, J H Leng, J H Lang
Obiective: To explore the risk factors of endometriosis-associated ovarian cancer (EAOC) in women with ovarian endometriosis aged 45 years and older in China. Methods: The medical records of total 1 038 women aged 45 years and older with a surgicopathological diagnosis of ovarian endometriosis treated at Peking Union Medical College Hospital from December 1994 to December 2014 were reviewed. Histology evaluation determined ovarian endometriosis with (n=30) or without (n=1 008) ovarian cancer. Results: (1) There were 30 (2...
May 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28544597/metastasis-of-soft-tissue-sarcomas-in-lymph-node-a-cytomorphological-study
#2
Jahnavi Gandhi, Shailee Mehta, Trupti Patel, Amisha Gami, Majal Shah, Dhaval Jetly
BACKGROUND: Soft-tissue sarcoma (STS) rarely metastasizes to lymph node compared to carcinoma. Fine-needle aspiration cytology (FNAC) carries a pivotal role in diagnosis of metastatic tumor to lymph node. This study highlights the role of FNAC in diagnosis of STS metastasis to lymph node. METHOD: A retrospective study over a period by 4 years carried out. FNAC of enlarged lymph node was performed in patients with STS. Cytology smears were examined in conjunction with clinical details...
May 24, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28544573/spindle-cell-subtype-of-pulmonary-clear-cell-tumor-with-prominent-calcification-and-malignant-potential
#3
Yinghua Song, Fangfang Chen, Caiqing Zhang, Xiaoyan Lin
Perivascular epithelioid cell tumor of the lung, also known as clear cell "sugar" tumor, is a rare benign tumor arising from perivascular epithelioid cells. Herein, we present a case of spindle cell subtype of pulmonary perivascular epithelioid cell tumor with prominent calcification and malignant potential in a 49-year-old woman. Histologically, the striking feature of this lesion was attributed to the presence of spindle cells arranged in a diffuse pattern, which is a pitfall for diagnosis. However, some of the lesion contained polygonal tumor cells with clear abundant cytoplasm surrounded by thin-walled vascular spaces...
May 25, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28544435/solid-renal-masses-in-transplanted-allograft-kidneys-a-closer-look-at-the-epidemiology-and-management
#4
John J Griffith, Katherine A Amin, Nikhil Waingankar, Susan M Lerner, Veronica Delaney, Scott A Ames, Ketan Badani, Michael A Palese, Reza Mehrazin
The objective of this review is to explore the available literature on solid renal masses (SRM) in transplant allograft kidneys to better understand the epidemiology and management of these tumors. A literature review using PubMed was performed according to the PRISMA methodology. Fifty-six relevant studies were identified from 1988-2015. A total of 174 SRMs in 163 patients, were identified with a mean tumor size of 2.75 cm (0.5-9.0cm). Tumor histology was available in 164 (94.3%) tumors: clear cell renal cell carcinoma (RCC) (45...
May 19, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28544385/korean-red-ginseng-extract-enhances-the-anticancer-effects-of-sorafenib-through-abrogation-of-creb-and-c-jun-activation-in-renal-cell-carcinoma
#5
Chulwon Kim, Jong Hyun Lee, Seung Ho Baek, Jeong-Hyeon Ko, Dongwoo Nam, Kwang Seok Ahn
Although application of sorafenib in the treatment of human renal cell carcinoma (RCC) remains one of the best examples of successful targeted therapy, majority of RCC patients suffer from its side effects as well as develop resistance to this targeted therapy. Thus, there is a need to promote novel alternative therapies for the treatment of RCC. In this study, we investigated whether Korean red ginseng extract (KRGE) could inhibit the proliferation and induce chemosensitization in human renal cancer cells...
May 22, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28543713/potential-protective-role-of-grainyhead-like-genes-in-the-development-of-clear-cell-renal-cell-carcinoma
#6
Magdalena Pawlak, Agnieszka Kikulska, Tomasz Wrzesinski, Tobias Rausch, Zbigniew Kwias, Bartek Wilczynski, Vladimir Benes, Joanna Wesoly, Tomasz Wilanowski
The involvement of Grainyhead-like (GRHL) transcription factors in various cancers is well documented. However, little is known about their role in clear cell renal cell carcinoma (ccRCC). We discovered that the expression of two of these factors - GRHL1 and GRHL2-is downregulated in ccRCC samples, and their expression is correlated with the expression of VHL gene. This suggests a functional link between the GRHL transcription factors and one of the best known tumor suppressors. Although the GRHL genes are not mutated in ccRCC, some of the single nucleotide polymorphisms in these genes may indicate an increased risk of ccRCC development and/or may allow to assess patients' prognoses and predict their responses to various forms of therapy...
May 23, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28543546/bmp4-enhances-hepatocellular-carcinoma-proliferation-by-promoting-cell-cycle-progression-via-id2-cdkn1b-signaling
#7
Junli Ma, Shan Zeng, Yan Zhang, Ganlu Deng, Yanlin Qu, Cao Guo, Ling Yin, Ying Han, Hong Shen
Bone morphogenetic protein-4 (BMP4) plays a crucial role in carcinogenesis, but the effects and signaling mechanisms of BMP4 in hepatocellular carcinoma (HCC) are not clearly clarified. The present study aimed to identify the roles of BMP4 in the proliferation of human HCC. In this study, BMP4 expression and its correlation with clinicopathological characteristics and the survival of HCC patients were analyzed in two independent cohorts consisting of 310 subjects. Functional analysis of BMP4 on HCC proliferation was performed in vitro and in vivo in human HCC specimens, HCC cells of Bel-7402 and HCCLM3, and subcutaneous tumor model...
May 23, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28541642/surgical-management-of-non-invasive-uterine-clear-cell-carcinoma
#8
EDITORIAL
Toru Sugiyama, Satoshi Takeuchi, Hiroaki Itamochi
No abstract text is available yet for this article.
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28541641/update-on-rare-epithelial-ovarian-cancers-based-on-the-rare-ovarian-tumors-young-investigator-conference
#9
REVIEW
Ji Yon Agnes Jang, Nozomu Yanaihara, Eric Pujade-Lauraine, Yoshiki Mikami, Katsutoshi Oda, Michael Bookman, Jonathan Ledermann, Muneaki Shimada, Takako Kiyokawa, Byoung Gie Kim, Noriomi Matsumura, Tsunehisa Kaku, Takafumi Kuroda, Yoko Nagayoshi, Ayako Kawabata, Yasushi Iida, Jae Weon Kim, Michael Quinn, Aikou Okamoto
There has been significant progress in the understanding of the pathology and molecular biology of rare ovarian cancers, which has helped both diagnosis and treatment. This paper provides an update on recent advances in the knowledge and treatment of rare ovarian cancers and identifies gaps that need to be addressed by further clinical research. The topics covered include: low-grade serous, mucinous, and clear cell carcinomas of the ovary. Given the molecular heterogeneity and the histopathological rarity of these ovarian cancers, the importance of designing adequately powered trials or finding statistically innovative ways to approach the treatment of these rare tumors has been emphasized...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28541637/prognostic-factors-and-treatment-outcomes-in-surgically-staged-non-invasive-uterine-clear-cell-carcinoma-a-turkish-gynecologic-oncology-group-study
#10
Mustafa Erkan Sarı, Mehmet Mutlu Meydanlı, Osman Türkmen, Günsü Kimyon Cömert, Ahmet Taner Turan, Alper Karalök, Hanifi Şahin, Ali Haberal, Eda Kocaman, Özgür Akbayır, Baki Erdem, Ceyhun Numanoğlu, Kemal Güngördük, Muzaffer Sancı, Mehmet Gökçü, Nejat Özgül, Mehmet Coşkun Salman, Gökhan Boyraz, Kunter Yüce, Tayfun Güngör, Salih Taşkın, Duygun Altın, Uğur Fırat Ortaç, Hülya Aydın Ayık, Tayup Şimşek, Macit Arvas, Ali Ayhan
OBJECTIVE: To assess the prognosis of surgically-staged non-invasive uterine clear cell carcinoma (UCCC), and to determine the role of adjuvant therapy. METHODS: A multicenter, retrospective department database review was performed to identify patients with UCCC who underwent surgical treatment between 1997 and 2016 at 8 Gynecologic Oncology Centers. Demographic, clinicopathological, and survival data were collected. RESULTS: A total of 232 women with UCCC were identified...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28538028/unnecessary-cost-of-post-mohs-permanent-pathology
#11
Kelly M MacArthur, Nikki Tang, George J Hruza, Timothy S Wang, Robert G Egbers
BACKGROUND: By providing tumor-free margins, Mohs micrographic surgery (MMS) results in high cure rates in the treatment of nonmelanoma skin cancers (NMSCs). However, when closure of the post-MMS defect is coordinated with reconstructive surgery, redundant tissue is sometimes submitted for permanent section evaluation. OBJECTIVE: The purpose of our study was to investigate the frequency and effect of this practice. MATERIALS AND METHODS: Patients (12 years and older) with NMSCs cleared by MMS with coordinated closures from 2014 to 2016 were identified...
May 22, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28536740/-nivolumab-combined-with-ipilimumab-versus-sunitinib-monotherapy-sunniforecast-an-41-16-of-the-auo-a-phase-2-randomized-open-label-study-in-subjects-with-previously-untreated-and-advanced-unresectable-or-metastatic-non-clear-cell-renal-cell-carcinoma
#12
https://www.readbyqxmd.com/read/28536669/disparate-presentations-of-localized-cystic-disease-of-kidney-a-review-with-an-objective-of-correct-approach-for-accurate-treatment-plan
#13
Sachin Khanduri, Mriganki Chaudhary, Tushar Sabharwal, Aakshit Goyal, Gaurav Katyal
BACKGROUND: Localized cystic disease of the kidney is a rare, non-familial condition. Its imaging and clinical features are unique and need to be differentiated from autosomal dominant polycystic kidney disease and focal cystic masses such as multicystic nephroma and cystic renal cell carcinoma. It is always restricted to one kidney and is characterized by multiple cysts of varying sizes separated by residual normal renal tissue. MATERIALS AND METHODS: This study reports 12 cases of localized cystic disease of the kidney based on imaging findings and clinical histories...
April 22, 2017: Curēus
https://www.readbyqxmd.com/read/28536496/link-between-dysregulated-hypoxia-signaling-and-aberrant-methylation-in-clear-cell-renal-cell-carcinoma
#14
Niraj Shenoy
No abstract text is available yet for this article.
April 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28534944/high-mir-122-expression-promotes-malignant-phenotypes-in-ccrcc-by-targeting-occludin
#15
Kentaro Jingushi, Yuri Kashiwagi, Yuko Ueda, Kaori Kitae, Hiroaki Hase, Wataru Nakata, Kazutoshi Fujita, Motohide Uemura, Norio Nonomura, Kazutake Tsujikawa
Renal cell carcinoma (RCC) is the most common neoplasm of the adult kidney, and clear cell RCC (ccRCC) represents its most common histological subtype. Although several studies have reported high expression of miR-122 in ccRCC, its physiological role remains unclear. To clarify the role of miR-122 in ccRCC, we compared miR-122 expression levels in non-cancerous tissue and ccRCC. Significant upregulation of miR-122 was observed in ccRCC specimens. Moreover, ccRCC patients with high miR-122 expression showed poor progression-free survival compared to those with low miR-122 expression...
May 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28533485/high-expression-of-fut3-is-linked-to-poor-prognosis-in-clear-cell-renal-cell-carcinoma
#16
Li Meng, Le Xu, Yuanfeng Yang, Lin Zhou, Yuan Chang, Tianming Shi, Cheng Tan, Huimin An, Yu Zhu, Jiejie Xu
BACKGROUND AND PURPOSE: Some of the fucosylation catalyzed by fucosyltransferase-III mediates the epithelial-mesenchymal transition and enhances tumor cell-macrophage signaling, which promotes malignant transforming and immune evasion. The aim of the study was to investigate the association between the expression of fucosyltransferase-III and clinical outcomes of patients with clear-cell renal cell carcinoma after surgery. RESULTS: High fucosyltransferase-III expression was associated with a greater risk of recurrence (p = 0...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28533474/weekly-low-dose-versus-three-weekly-high-dose-cisplatin-for-concurrent-chemoradiation-in-locoregionally-advanced-non-nasopharyngeal-head-and-neck-cancer-a-systematic-review-and-meta-analysis-of-aggregate-data
#17
Petr Szturz, Kristien Wouters, Naomi Kiyota, Makoto Tahara, Kumar Prabhash, Vanita Noronha, Ana Castro, Lisa Licitra, David Adelstein, Jan B Vermorken
BACKGROUND: Three-weekly high-dose cisplatin (100 mg/m(2)) is considered the standard systemic regimen given concurrently with postoperative or definitive radiotherapy in locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). However, due to unsatisfactory patient tolerance, various weekly low-dose schedules have been increasingly used in clinical practice. The aim of this meta-analysis was to compare the efficacy, safety, and compliance between these two approaches...
May 22, 2017: Oncologist
https://www.readbyqxmd.com/read/28533271/vhl-inactivation-in-precancerous-kidney-cells-induces-an-inflammatory-response-via-er-stress-activated-ire1%C3%AE-signaling
#18
Chan-Yen Kuo, Chih-Hung Lin, Tien Hsu
Mutations and epigenetic inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) are major causes of clear-cell renal cell carcinoma (ccRCC) that may originate from chronic inflammation. However, the role of VHL loss-of-function in the development of ccRCC via inflammation remains poorly understood. VHL mutant cells exhibit metabolic abnormalities that can cause chronic endoplasmic reticulum (ER) stress and unfolded protein response (UPR). We hypothesize that unresolved ER stress induces the inflammatory responses observed in ccRCC...
May 22, 2017: Cancer Research
https://www.readbyqxmd.com/read/28533051/features-of-ipsilateral-renal-recurrences-after-partial-nephrectomy-a-proposal-of-a-pathogenetic-classification
#19
Alessandro Antonelli, Maria Furlan, Regina Tardanico, Simona Fisogni, Mario Sodano, Francesca Carobbio, Sandra Belotti, Alberto Cozzoli, Tiziano Zanotelli, Claudio Simeone
BACKGROUND: Poor data are reported on the pathogenesis of ipsilateral relapse (IR) after partial nephrectomy (PN). The objective of this study was to investigate features of IR after PN with the intention to propose a pathogenetic classification. MATERIALS AND METHODS: Retrospective consultation of an institutional database that stores the data of 683 patients submitted to PN since 1993. The clinical, radiological, and follow-up data of the cases submitted to salvage nephrectomy due to an IR were analyzed...
April 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28529742/intraductal-tubulopapillary-neoplasm-accompanied-by-invasive-carcinoma-of-the-pancreas-a-case-report-and-review-of-the-literature
#20
Li Niu, Zhigao Xu, Huan Liu, Hong Cao, Guifang Yang
Intraductal tubulopapillary neoplasms (ITPNs) are rare pancreatic neoplasms accounting for ~0.4% of pancreatic tumors. However, their clinicopathological characteristics have not been clearly determined and the number of available clinical studies on this type of tumor is limited at present. Due to the rare incidence of ITPN, diagnosis is often delayed. We herein present a unique case of a 38-year-old man who was diagnosed with ITPN accompanied with invasive carcinoma of the pancreas and underwent total pancreatectomy...
May 2017: Molecular and Clinical Oncology
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