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Endometrioid carcinoma

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https://www.readbyqxmd.com/read/29146630/a-role-for-cxcr4-in-peritoneal-and-hematogenous-ovarian-cancer-dissemination
#1
Agnes Figueras, Elisenda Alsina-Sanchís, Alvaro Lahiguera, Manuel Abreu, Laura Muinelo-Romay, Gema Moreno-Bueno, Oriol Casanovas, Mariona Graupera, Xavier Matias-Guiu, August Vidal, Alberto Villanueva, Francesc Viñals
Epithelial ovarian cancer is characterized by a low recovery rate because the disease is typically diagnosed at an advanced stage, by which time, most patients (80%) already exhibit disseminated neoplasia. The cytokine receptor CXCR4 has been implicated in the development of metastasis in various tumor types. Using a patient-derived tissue macroarray and mRNA expression analysis we observed high CXCR4 levels in high-grade serous epithelial ovarian carcinomas, the most metastatic tumor, compared with those in endometrioid carcinomas...
November 16, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29140883/mage-a4-and-mage-a1-immunohistochemical-expression-in-high-grade-endometrial-cancer
#2
Sanja Srdelić, Ivana Kuzmić-Prusac, Giulio C Spagnoli, Antonio Juretić, Vesna Čapkun
The aim was to investigate MAGE-A4 and MAGE-A1 protein expression in high-grade endometrial cancer and determine its correlation with histologic subtype, FIGO stage, presence of vascular invasion, disease free, and overall survival. Immunohistochemical staining was performed by using 77B (MAGE-A1) and 57B (MAGE-A4) monoclonal antibodies on paraffin-embedded sections from high-grade endometrial cancers diagnosed in University Hospital Split between 1998 and 2011 (n=77). Median follow-up time for survivors was 48 mo...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29137657/p53-aberrations-in-low-grade-endometrioid-carcinoma-of-the-endometrium-with-nodal-metastases-possible-insights-on-pathogenesis-discerned-from-immunohistochemistry
#3
Oluwole Fadare, Vinita Parkash
BACKGROUND: TP53 mutations are rarely identified in low grade endometrioid carcinoma of the endometrium, and their pathogenic significance in such tumors is evidenced by the fact that TP53 aberrations have been associated with reduced recurrence-free survival in this subset of tumors. However, TP53 aberrations may not always represent a driving molecular event in a given endometrial cancer with a mutation. In this case study, the immunophenotype of a distinctive low grade endometrioid adenocarcinoma with an unusual pattern of lymph node metastases is used to explore the possible roles for underlying TP53-related molecular events in its pathogenesis...
November 14, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/29137401/hormone-receptors-expression-in-ovarian-cancer-taking-into-account-menopausal-status-a-retrospective-study-in-chinese-population
#4
Fang Shen, Xuyin Zhang, Yiqun Zhang, Jingxin Ding, Qi Chen
Ovarian cancer is a major gynaecological cancer with different subtypes and studies have suggested that estrogen receptor (ER) or progesterone receptor (PR) positivity are associated with better clinical outcomes. Furthermore, the clinical outcomes of ovarian cancer are better in Asian compared to Caucasian. To date, studies investigating the ER or PR positivity in all subtypes of ovarian cancer, including borderline epithelial, are limited. In this retrospective study we investigated ER and PR positivity in Chinese women with malignant epithelial ovarian cancer (n=577), sex cord-stromal tumor (n=26) and borderline epithelial ovarian cancer (n=98) taking into account menopausal status...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29135516/international-endocervical-adenocarcinoma-criteria-and-classification-iecc-a-new-pathogenetic-classification-for-invasive-adenocarcinomas-of-the-endocervix
#5
Simona Stolnicu, Iulia Barsan, Lien Hoang, Prusha Patel, Cristina Terinte, Anna Pesci, Sarit Aviel-Ronen, Takako Kiyokawa, Isabel Alvarado-Cabrero, Malcolm C Pike, Esther Oliva, Kay J Park, Robert A Soslow
We sought to classify endocervical adenocarcinomas (ECAs) based on morphologic features linked to etiology (ie, human papillomavirus [HPV] infection), unlike the World Health Organization 2014 classification. The International Endocervical Adenocarcinoma Criteria and Classification (IECC criteria), described herein, distinguishes between human papillomavirus-associated adenocarcinoma (HPVA), recognized by the presence of luminal mitoses and apoptosis seen at scanning magnification, and no or limited HPVA features (nonhuman papillomavirus-associated adenocarcinoma [NHPVA])...
November 9, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29135119/expression-and-significance-of-arid1a-mrna-in-endometriosis-associated-ovarian-cancer
#6
Qiong Wang, Lingxiong Wang, Yali L, Xiaohui Ding, Aijun Liu
PURPOSE: To investigate the expression and relevant clinical and pathological significance of AT-rich interactive domaincontaining protein 1A (ARID1A) mRNA in endometriosis-associated ovarian cancer. METHODS: The clinical and pathological data of 63 patients with ovarian clear cell carcinoma (OCCC) and of 43 patients with ovarian endometrioid adenocarcinoma (OEAC) were collected. The expression of ARID1A-encoded protein, baf250a, in ovarian cancer tissues was detected using immunohistochemistry...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29133142/dedifferentiated-endometrial-carcinomas-with-neuroendocrine-features-a-clinicopathologic-immunohistochemical-and-molecular-genetic-study
#7
Iñigo Espinosa, Antonio De Leo, Emanuela D'Angelo, Juan M Rosa-Rosa, Marina Corominas, Alan Gonzalez, José Palacios, Jaime Prat
Undifferentiated endometrial carcinoma is an aggressive type of uterine cancer which is occasionally associated with a low-grade endometrioid carcinoma component. This combination is referred to as "dedifferentiated endometrioid endometrial carcinoma." Neuroendocrine expression may occur in undifferentiated endometrial carcinoma but its significance in dedifferentiated endometrial carcinomas is unknown. To gain insight into the pathogenesis of these tumors we have analyzed the immunophenotype (ARID1A, MLH1, PMS2, MSH2, MSH6, p53, b-catenin, SMARCB1, synaptophysin, chromogranin A, and CD56) and mutational status (PTEN, KRAS, PIK3CA, TP53 and POLE) of 4 dedifferentiated endometrial carcinomas with strong and diffuse neuroendocrine expression...
November 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/29132723/ovarian-sex-cord-stromal-tumours-and-their-mimics
#8
REVIEW
Robert H Young
Sex cord-stromal tumours of the ovary include many of the most morphologically intriguing ovarian neoplasms and albeit many of them are rare, they factor into the differential diagnosis more often than their frequency might suggest. The most common malignant form, the adult granulosa cell tumour, may grossly simulate various surface epithelial neoplasms. Microscopically, confusion with endometrioid carcinoma may occur because the cords and microfollicles of the granulosa cell tumour may be mimicked by endometrioid carcinoma and the latter may have pale nuclei with nuclear grooves...
November 10, 2017: Pathology
https://www.readbyqxmd.com/read/29129333/pitfalls-in-the-interpretation-of-specimens-from-patients-with-testicular-tumours-with-an-emphasis-on-variant-morphologies
#9
REVIEW
Thomas M Ulbright
Accurate diagnosis of primary and metastatic tumours is essential in testicular cancer. While many cases are straightforward, some pose difficulties, especially when variant morphologies occur. Seminoma with 'atypical' features, including increased nuclear pleomorphism and crowding and greater cytoplasmic density with loss of membrane definition, mimics embryonal carcinoma, although ancillary features (fibrous septa, lymphocytes) and immunohistochemistry are of great help. Other deceptive seminoma features include prominent to exclusive intertubular growth, microcystic/tubular patterns, and signet-ring tumour cells...
November 9, 2017: Pathology
https://www.readbyqxmd.com/read/29114696/the-prognostic-significance-of-preoperative-serum-cancer-antigen-15-3-levels-in-endometrial-carcinomas
#10
Emre E Tas, Ayse F Yavuz
To determine the associations between serum cancer antigen 15-3 levels and prognostic factors in patients with endometrial carcinomas. Additionally, we investigated the clinical utility of serum cancer antigen 15-3 levels in the selection of low-risk patients with endometrioid type, tumor size less than 2 cm, myometrial invasion ≤50%, and histological grade 1-2. Methods: Ninety-six patients, who were surgically staged at  Ankara Yildirim Beyazit University, Ankara, Turkey, between 2007 and 2016, were retrospectively analyzed...
November 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/29113327/the-prevalence-of-malignant-and-borderline-ovarian-cancer-in-pre-and-post-menopausal-chinese-women
#11
Fang Shen, Shouzhen Chen, Yifei Gao, Xujing Dai, Qi Chen
The incidence of ovarian cancer depends on the ethnicity and geographical area. Menopausal status is a well-known risk factor for ovarian cancer and most cases occur after menopause in Caucasians. However, it is less clear how the status of menopause or age at diagnosis is associated with ovarian cancer including its subtypes in Chinese women. Data on 1,283 women with primary malignant or borderline ovarian cancer including age at diagnosis, age at menopause and histology from the largest women's hospital in China was analysed...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29113165/the-prognostic-significance-of-tumor-lymphangiogenesis-and-lymphatic-vessel-density-in-endometrioid-carcinoma-of-the-uterine-corpus
#12
Mika Sakaki, Masanori Yasuda, Mitsutake Yano, Yoshiya Goto, Masaru Nakamura, Hidekazu Kayano, Kosei Hasegawa
The present study aimed to assess the prognostic significance of tumor lymphangiogenesis and lymphatic vessel density (LVD) in endometrioid carcinoma of the uterine corpus. The association between LVD and various factors, including lymphatic vessel invasion (LVI), and nodal metastases, were investigated. Among 202 surgically treated cases, 19 cases with nodal metastases with the infiltration reaching the outer-half myometrium (N(+) group) were selected. The LVDs of hotspots in each case were examined at 100× magnification on D2-40 stained slides of the inner- and outer-half myometrium of the peritumoral, and control compartments...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29113150/aberrant-chromatin-remodeling-in-gynecological-cancer
#13
Ryuichiro Okawa, Kouji Banno, Miho Iida, Megumi Yanokura, Takashi Takeda, Moito Iijima, Haruko Kunitomi-Irie, Kanako Nakamura, Masataka Adachi, Kiyoko Umene, Yuya Nogami, Kenta Masuda, Yusuke Kobayashi, Eiichiro Tominaga, Daisuke Aoki
Epigenetic regulatory mechanisms are a current focus in studies investigating cancer. Chromatin remodeling alters chromatin structure and regulates gene expression, and aberrant chromatin remodeling is involved in carcinogenesis. AT-rich interactive domain-containing protein 1A (ARID1A) and SWItch/sucrose non-fermentable-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4 are remodeling factors that are mutated in numerous types of cancer. In gynecological cancer, ARID1A mutations have been identified in 46-57% of clear cell carcinoma and 30% of endometrioid carcinoma...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29113136/discovering-the-deregulated-molecular-functions-involved-in-malignant-transformation-of-endometriosis-to-endometriosis-associated-ovarian-carcinoma-using-a-data-driven-function-based-analysis
#14
Chia-Ming Chang, Yi-Ping Yang, Jen-Hua Chuang, Chi-Mu Chuang, Tzu-Wei Lin, Peng-Hui Wang, Mu-Hsien Yu, Cheng-Chang Chang
The clinical characteristics of clear cell carcinoma (CCC) and endometrioid carcinoma EC) are concomitant with endometriosis (ES), which leads to the postulation of malignant transformation of ES to endometriosis-associated ovarian carcinoma (EAOC). Different deregulated functional areas were proposed accounting for the pathogenesis of EAOC transformation, and there is still a lack of a data-driven analysis with the accumulated experimental data in publicly-available databases to incorporate the deregulated functions involved in the malignant transformation of EOAC...
November 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29107108/long-non-coding-rna-hand2-as1-inhibits-invasion-and-metastasis-in-endometrioid-endometrial-carcinoma-through-inactivating-neuromedin-u
#15
Xueying Yang, Chi Chiu Wang, Wayne Yuk Wai Lee, Jone Trovik, Tony Kwok Hung Chung, Joseph Kwong
Endometrioid endometrial carcinoma (EEC) is one of the common causes of cancer-related mortality in women. Mounting evidences suggest that long noncoding RNAs (lncRNAs) function in multiple cancers. In this study, we discovered that HAND2-AS1, a lncRNA transcribed antisense adjacent to Heart and Neural Crest Derivatives Expressed 2 (HAND2) in chromosome 4q33-34, is significantly down-regulated in EEC. HAND2-AS1 and HAND2 were frequently down-regulated in EEC tissues, especially in poor differentiated tumor tissues...
October 26, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29105363/cytomorphologic-features-of-metastatic-endometrioid-carcinoma-by-fine-needle-aspiration
#16
Daniel N Johnson, Julieta E Barroeta, Tatjana Antic, Ricardo R Lastra
BACKGROUND: Although metastatic disease is commonly seen in high grade carcinomas of gynecologic origin, it also occurs in low to intermediate grade endometrioid carcinomas (LGEMCAs), and may even be the primary presentation of disease. Tissue confirmation is necessary to guide therapy, but performing biopsies might not always be feasible or practical. In such instances, fine needle aspiration (FNA) is a safe and efficient alternative. No comprehensive series describing the cytomorphologic features of metastatic LGEMCA on FNA samples has been published...
November 4, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29102090/comprehensive-genomic-profiling-reveals-inactivating-smarca4-mutations-and-low-tumor-mutational-burden-in-small-cell-carcinoma-of-the-ovary-hypercalcemic-type
#17
Douglas I Lin, Yakov Chudnovsky, Bridget Duggan, Deborah Zajchowski, Joel Greenbowe, Jeffrey S Ross, Laurie M Gay, Siraj M Ali, Julia A Elvin
OBJECTIVE: Small cell carcinoma of the ovary, hypercalcemic-type (SCCOHT) is a rare, extremely aggressive neoplasm that usually occurs in young women and is characterized by deleterious germline or somatic SMARCA4 mutations. We performed comprehensive genomic profiling (CGP) to potentially identify additional clinically and pathophysiologically relevant genomic alterations in SCCOHT. METHODS: CGP assessment of all classes of coding alterations in up to 406 genes commonly altered in cancer and intronic regions for up to 31 genes commonly rearranged in cancer was performed on 18 SCCOHT cases (16 exhibiting classic morphology and 2 cases exhibiting exclusive a large cell variant morphology)...
October 25, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29096882/asparaginase-like-protein-1-is-an-independent-prognostic-marker-in-primary-endometrial-cancer-and-is-frequently-lost-in-metastatic-lesions
#18
Tina Fonnes, Hege F Berg, Therese Bredholt, Per-Henrik D Edqvist, Kristina Sortland, Anna Berg, Helga B Salvesen, Lars A Akslen, Henrica M J Werner, Jone Trovik, Ingvild L Tangen, Camilla Krakstad
OBJECTIVE: Loss of Asparaginase-like protein 1 (ASRGL1) has been suggested as a prognostic biomarker in endometrial carcinoma. Our objective was to validate this in a prospectively collected, independent patient cohort, and evaluate ASRGL1 expression in endometrial carcinoma precursor lesion and metastases. METHODS: 782 primary endometrial carcinomas, 90 precursor lesions (complex atypical hyperplasia), and 179 metastases (from 87 patients) were evaluated for ASRGL1 expression by immunohistochemistry in relation to clinical and histopathological data...
October 30, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29093822/ezh2-inhibition-in-arid1a-mutated-clear-cell-and-endometrioid-ovarian-and-endometrioid-endometrial-cancers
#19
REVIEW
Jill K Alldredge, Ramez N Eskander
Clear cell carcinoma and endometrioid adenocarcinoma are histologic subtypes of ovarian and uterine cancer that demonstrate unique clinical behavior but share common underlying genomic aberrations and oncogenic pathways. ARID1A mutations are more frequently identified in these tumors, in comparison to other gynecologic histologies, and loss of ARID1A tumor suppressor function is thought to be an essential component of carcinogenic transformation. Several therapeutic targets in ARID1A mutated cancers are in development, including EZH2 inhibitors...
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/29079180/mixed-endometrial-carcinomas-with-a-low-grade-serous-like-component-a-clinicopathologic-immunohistochemical-and-molecular-genetic-study
#20
Iñigo Espinosa, Emanuela D'Angelo, Marina Corominas, Alan Gonzalez, Jaime Prat
Recently, we reported 2 mixed endometrioid endometrial carcinomas with a low-grade serous-like component which doesn't fit into any of the 4 molecular groups described by The Cancer Genome Atlas (TCGA). In order to understand the nature of these tumors, we have done an immunohistochemical and molecular genetic study of these two cases and added a third case. Immunoreactivity for p53, ER, Ki67, WT1, MLH1, PMS2, MSH2, and MSH6 were assessed. Targeted next-generation sequencing for somatic mutations, including genes commonly implicated in carcinogenesis including TP53, KRAS, and PIK3CA, and Sanger sequencing for PTEN and POLE were also performed...
October 24, 2017: Human Pathology
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