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Endometrioid carcinoma

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https://www.readbyqxmd.com/read/29785550/does-tumor-grade-influence-the-rate-of-lymph-node-metastasis-in-apparent-early-stage-ovarian-cancer
#1
Dimitrios Nasioudis, Spyridon A Mastroyannis, Emily M Ko, Nawar A Latif
PURPOSE: To evaluate the prevalence of regional lymph node (LN) metastasis in patients with non-clear cell epithelial ovarian cancer apparently confined to the ovary, stratified by tumor grade. METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was accessed (1988-2014). We identified patients with epithelial ovarian carcinoma of serous, endometrioid and mucinous histology apparently confined to the ovary who underwent extensive lymphadenectomy (defined as at least 20 lymph nodes removed)...
May 21, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29780776/preoperative-serum-levels-of-cancer-antigen-125-and-carcinoembryonic-antigen-ratio-can-improve-differentiation-between-mucinous-ovarian-carcinoma-and-other-epithelial-ovarian-carcinomas
#2
Ji Hui Choi, Geum Seon Sohn, Doo Byung Chay, Han Byoul Cho, Jae-Hoon Kim
Objective: The main aim of this study was to evaluate cancer antigen 125 (CA125)/carcinoembryonic antigen (CEA) ratio (CCR), as a reliable marker to differentiate ovarian mucinous carcinoma from other epithelial ovarian carcinomas (EOCs), namely serous, clear cell, and endometrioid carcinomas. Methods: Female patients suffering from different kinds of EOCs whom were subjected to elective surgery at the Gangnam Severance Hospital between January 2008 and December 2016, were included in this study...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29779939/endometrial-carcinoma-in-a-single-horn-of-a-bicornuate-uterus-a-case-report
#3
Khaled Gaballa, Carla Cicero, Valerio Gallotta, Gianfranco Zannoni, Giovanni Scambia
We discuss the diagnosis and the management of endometrial carcinoma in a single horn of bicornuate uterus in a 64-year-old woman as a case report. The case underwent laparoscopic radical hysterectomy and bilateral iliac lymphadenectomy. The gross examination of the uterus revealed a bicornuate uterus with a greater horn of 12 × 9 × 8 cm and a smaller horn of 10 × 3 cm. The cavity of the greater horn showed a neoplastic growth of 10 cm with infiltration of about 1,8 cm of the myometrium from whole thickness of 1...
May 17, 2018: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/29779470/ascites-derived-extracellular-micrornas-as-potential-biomarkers-for-ovarian-cancer
#4
Luděk Záveský, Eva Jandáková, Vít Weinberger, Luboš Minář, Veronika Hanzíková, Daniela Dušková, Lenka Záveská Drábková, Iveta Svobodová, Aleš Hořínek
Ovarian cancer as the most fatal gynecological malignancy is often manifested by excessive fluid accumulation known as ascites or effusion. Ascites-derived microRNAs (miRNAs) may be closely associated with ovarian cancer progression. However, our knowledge of their roles, altered expression, and clinical outcomes remained limited. In this study, large-scale expression profiling of 754 human miRNAs was performed using real-time quantitative polymerase chain reaction and 384-well TaqMan array human miRNA A and B cards to identify differentially expressed miRNAs between extracellular fraction of the ascitic fluid associated with high-grade serous ovarian carcinomas and control plasma...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29769513/ovarian-endometrioid-adenocarcinoma-arising-in-endometriosis-a-case-report
#5
K Nahar, B Ferdous, N Akhter, P A Shamsunnahar, K Khatun, S A Begum, M A Aziz
Malignant transformation of ovarian endometriosis was first described in 1925 by Sampson; later on it has been described in extragonadal regions by few authors also. Ovarian endometrioid and clear cell carcinoma are highly associated with endometriosis. Here we present a case of malignant transformation of ovarian endometrioma into endometrioid adenocarcinoma and review the clinical and pathological features of these tumors. A 45-years old infertile woman diagnosed as a case of bilateral chocolate cyst with pelvic endometriosis underwent total hysterectomy with bilateral salpingo-oophorectomy...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29750701/comprehensive-surgical-staging-in-stage-1-clear-cell-and-endometrioid-ovarian-carcinomas-is-it-necessary
#6
Radha R Padhy, Johanna Savage, Robert J Kurman
The objective of this article was to evaluate the presence of occult metastasis after comprehensive surgical staging of clear cell ovarian carcinoma (CCC) and endometrioid ovarian carcinoma (EMCA) that appeared to be confined to the ovary at time of surgery. Between 1998 to 2016, 85 patients with CCC and EMCA were identified who were comprehensively staged and felt to be stage 1 intraoperatively. Of the 85 patients who underwent surgical staging, 4 (4.7%) had omental and dense pelvic side-wall tumor adhesions...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29747687/androgen-receptor-expression-in-endometrial-carcinoma-and-its-correlation-with-clinicopathologic-features
#7
Atif Ali Hashmi, Zubaida Fida Hussain, Amna Qadri, Muhammad Irfan, Sahar Ramzan, Naveen Faridi, Amir Khan, Muhammad Muzzammil Edhi
OBJECTIVES: Recent evidence suggests a role of androgen receptor expression as a prognostic and therapeutic biomarker in endometrial carcinoma, therefore in the present study we aimed to evaluate the frequency of androgen expression in different subtypes of endometrial carcinoma and its association with clinic-pathologic features. RESULTS: 18/89 (20.2%) cases of endometrial carcinoma showed positive androgen receptor expression. On the other hand, low, moderate and high androgen receptor expression was noted in 7/89 (7...
May 10, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29742675/risk-of-gynecologic-cancer-according-to-the-type-of-endometriosis
#8
Liisu Saavalainen, Heini Lassus, Anna But, Aila Tiitinen, Päivi Härkki, Mika Gissler, Eero Pukkala, Oskari Heikinheimo
OBJECTIVE: To assess the risks of gynecologic cancer according to the type of endometriosis in women with surgically verified endometriosis. METHODS: This is a population-based study of women with surgically verified endometriosis retrieved from the Finnish Hospital Discharge Register 1987-2012 (N=49,933); the subtypes of ovarian (n=23,210), peritoneal (n=20,187), and deep infiltrating (n=2,372) endometriosis were analyzed separately. Gynecologic cancers were obtained from the Finnish Cancer Registry...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29731976/predicting-high-risk-endometrioid-carcinomas-using-proteins
#9
Di Du, Wencai Ma, Melinda S Yates, Tao Chen, Karen H Lu, Yiling Lu, John N Weinstein, Russell R Broaddus, Gordon B Mills, Yuexin Liu
Background: The lethality of endometrioid endometrial cancer (EEC) is primarily attributable to advanced-stage diseases. We sought to develop a biomarker model that predicts EEC surgical stage at the time of clinical diagnosis. Results: PSES was significantly correlated with surgical stage in the TCGA cohort ( P < 0.0001) and in the validation cohort ( P = 0.0003). Even among grade 1 or 2 tumors, PSES was significantly higher in advanced than in early stage tumors in both the TCGA ( P = 0...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29731792/immunohistochemical-characterization-of-normal-ovary-and-common-epithelial-ovarian-neoplasm-with-a-monoclonal-antibody-to-cytokeratin-and-vimentin
#10
Ankita Goel, Nandam Mohan Rao, Vissa Santhi, Syam Sundar Byna, Bhavana Grandhi, Jyothi Conjeevaram
Background & Objective: The common epithelial ovarian tumors are classified into serous, mucinous, clear cell, endometrioid, the Brenner, mixed, and undifferentiated types. Cytoskeleton intermediate filament composition of ovarian tissues indicates that the cytokeratin and vimentin are observed in ovarian surface epithelium along with the common ovarian epithelial tumors. The current study aimed at investigating the cytokeratin and vimentin expression in epithelial ovarian tumors to establish a diagnostic relevance...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29727055/prognostic-factors-for-maximally-or-optimally-cytoreduced-stage-iii-nonserous-epithelial-ovarian-carcinoma-treated-with-carboplatin-paclitaxel-chemotherapy
#11
Zeliha F Cuylan, Mehmet M Meydanli, Mustafa E Sari, Ozgur Akbayir, Husnu Celik, Murat Dede, Hanifi Sahin, Kemal Gungorduk, Esra Kuscu, Nejat Ozgul, Tayfun Gungor, Ali Ayhan
OBJECTIVE: To identify factors predictive of poor prognosis in women with stage III nonserous epithelial ovarian cancer (EOC) who had undergone maximal or optimal primary cytoreductive surgery (CRS) followed by six cycles of intravenous carboplatin/paclitaxel chemotherapy. METHODS: A multicenter, retrospective department database review was performed to identify patients with stage III nonserous EOC who had undergone maximal or optimal primary CRS followed by six cycles of carboplatin/paclitaxel chemotherapy at seven gynecological oncology centers in Turkey...
May 4, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29725467/association-between-ovarian-cancer-and-advanced-endometriosis
#12
Michail Matalliotakis, Charoula Matalliotaki, George N Goulielmos, Evridiki Patelarou, Maria Tzardi, Demetrios A Spandidos, Aydin Arici, Ioannis Matalliotakis
We retrospectively analyzed clinicopathological data in two different countries over the past years on the association between ovarian endometriosis and ovarian carcinoma. Medical and pathological reports were evaluated from 1,000 patients with endometriosis from two different geographical areas. The prevalence and women characteristics of cases were analyzed. Endometriosis-associated ovarian cancer was present in 20 (2%) cases, among the study subjects. The observed prevalence was 12 (60%) for endometrioid carcinoma, 4 (20%) for clear cell ovarian carcinoma, 2 (10%) for serous and 2 (10%) for mucinous adenocarcinoma...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29721309/unraveling-endometriosis-associated-ovarian-carcinomas-using-integrative-proteomics
#13
Felix Leung, Marcus Q Bernardini, Kun Liang, Ihor Batruch, Marjan Rouzbahman, Eleftherios P Diamandis, Vathany Kulasingam
Background: To elucidate potential markers of endometriosis and endometriosis-associated endometrioid and clear cell ovarian carcinomas using mass spectrometry-based proteomics. Methods: A total of 21 fresh, frozen tissues from patients diagnosed with clear cell carcinoma, endometrioid carcinoma, endometriosis and benign endometrium were subjected to an in-depth liquid chromatography-tandem mass spectrometry analysis on the Q-Exactive Plus. Protein identification and quantification were performed using MaxQuant, while downstream analyses were performed using Perseus and various bioinformatics databases...
2018: F1000Research
https://www.readbyqxmd.com/read/29718305/invasive-epithelial-ovarian-cancer-survival-by-histotype-and-disease-stage
#14
Lauren C Peres, Kara L Cushing-Haugen, Martin Köbel, Holly R Harris, Andrew Berchuck, Mary Anne Rossing, Joellen M Schildkraut, Jennifer A Doherty
Background: The understanding of ovarian cancer pathogenesis has recently shifted to recognize distinct changes in how ovarian cancer histotypes are defined. Using the 2014 World Health Organization (WHO) diagnostic guidelines, we classified ovarian cancer histotypes in Surveillance, Epidemiology, and End Results (SEER) cancer registry data and examined survival patterns by histotype and disease stage. Methods: We extracted data on 28 118 incident epithelial ovarian cancer cases diagnosed in 2004-2014 from SEER and defined histotype using the 2014 WHO guidelines (high-grade serous, low-grade serous, endometrioid, clear cell, mucinous, carcinosarcoma, and malignant Brenner tumors)...
April 28, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29716549/lyl1-gene-amplification-predicts-poor-survival-of-patients-with-uterine-corpus-endometrial-carcinoma-analysis-of-the-cancer-genome-atlas-data
#15
Se Ik Kim, Ji Won Lee, Nara Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Jeong-Sun Seo
BACKGROUND: Somatic amplifications of the LYL1 gene are relatively common occurrences in patients who develop uterine corpus endometrial carcinoma (UCEC) as opposed to other cancers. This study was undertaken to determine whether such genetic alterations affect survival outcomes of UCEC. METHODS: In 370 patients with UCEC, we analysed clinicopathologic characteristics and corresponding genomic data from The Cancer Genome Atlas database. Patients were stratified according to LYL1 gene status, grouped as amplification or non-amplification...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29715099/clinicopathological-characteristics-and-kras-mutation-status-of-endometrial-mucinous-metaplasia-and-carcinoma
#16
Ji-Youn Sung, Yoon Yang Jung, Hyun-Soo Kim
BACKGROUND/AIM: Mucinous metaplasia of the endometrium occurs as a spectrum of epithelial alterations ranging from the formation of simple, tubular glands to architecturally complex glandular proliferation with intraglandular papillary projection and cellular tufts. Endometrial mucinous metaplasia often presents a diagnostic challenge in endometrial curettage. MATERIALS AND METHODS: We analyzed the clinicopathological characteristics and the mutation status for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) of 11 cases of endometrial mucinous metaplasia...
May 2018: Anticancer Research
https://www.readbyqxmd.com/read/29703038/dedifferentiated-endometrioid-adenocarcinoma-with-trophoblastic-components-and-elevated-serum-alfa-fetoprotein-a-case-report-and-literature-review
#17
He Cai, Rong Zhou, Wanying Liang, Jianliu Wang
RATIONALE: Dedifferentiated endometrioid adenocarcinoma (DEAC) consisted of a combination of undifferentiated and differentiated carcinoma is more aggressive than other conventional endometrioid adenocarcinomas. PATIENT CONCERNS: A 33-year-old woman with atypical vaginal bleeding was refereed to our hospital. She had an endometrial biopsy in a local clinic which showed differentiated endometrioid carcinoma with trophoblastic components. High levels of β-Human chorionic gonadotropin (β-hCG) and alfa-fetoprotein (AFP) were detected in the patient's serum...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29697394/specificities-of-endometrial-proliferation-stem-cell-index-distribution-in-endometrioid-carcinoma-of-different-grade-of-malignancy
#18
N Kikalishvili, R Beriashvili, T Muzashvili, G Burkadze
Endometrial neoplasia is the most common malignant tumor of female genital system in developed countries. The incidence of endometrial cancer has increased in the last years and despite advances in diagnosis and treatment, the death rates have steadily been increasing over the past 20 years. Therefore aspects of endometrial cancer development, pathogenesis and effective treatment is especially urgent to this day, as much of the risk for endometrial cancer development is influenced by the environment and lifestyle...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29695566/a-pathological-study-using-2014-who-criteria-reveals-poor-prognosis-of-grade-3-ovarian-endometrioid-carcinomas
#19
Hiroaki Soyama, Morikazu Miyamoto, Masashi Takano, Hideki Iwahashi, Kento Kato, Takahiro Sakamoto, Mika Kuwahara, Hiroki Ishibashi, Hiroko Matuura, Tomoyuki Yoshikawa, Tadashi Aoyama, Hitoshi Tsuda, Kenichi Furuya
BACKGROUND/AIM: The purpose of this study was to compare the clinical behavior of several grades of endometrioid carcinoma (EC) compared to high-grade serous carcinoma (HGSC), based on World Health Organization 2014 criteria. MATERIALS AND METHODS: Clinicopathological features were compared between all grades of EC and HGSC, and between HGSC and either grade 1/2 or grade 3 EC. RESULTS: Sixty-five patients with EC and 214 with HGSC were identified...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29693335/preoperative-monocyte-count-as-a-mirror-of-tumor-characteristics-and-likelihood-of-recurrence-in-endometrial-carcinoma-cases
#20
Mitra Modares Gilani, Zohreh Kazemi, Narges Zamani, Hadis Shahrami, Akram Ghahghaei-Nezamabadi, Soureh Sheikham
Background: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. Methods: We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 to March 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence...
April 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
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