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Endometrioid carcinoma

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https://www.readbyqxmd.com/read/28718916/the-genetic-landscape-of-endometrial-clear-cell-carcinomas
#1
Deborah F DeLair, Kathleen A Burke, Pier Selenica, Raymond S Lim, Sasinya N Scott, Sumit Middha, Abhinita S Mohanty, Donavan T Cheng, Michael F Berger, Robert A Soslow, Britta Weigelt
Clear cell carcinoma of the endometrium is a rare type of endometrial cancer generally associated with an aggressive clinical behavior. Here we sought to define the repertoire of somatic genetic alterations in endometrial clear cell carcinomas (ECCs) and whether ECCs could be classified into the molecular subtypes described for endometrial endometrioid and serous carcinomas. We performed a rigorous histopathological review, immunohistochemical analysis and massively parallel sequencing targeting 300 cancer-related genes of 32 pure ECCs...
July 18, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28718377/downregulation-of-tyrosine-threonine-kinase-inhibits-tumor-growth-via-g2-m-arrest-in-human-endometrioid-endometrial-adenocarcinoma
#2
Jiamiao Zhang, Yan Jiang, Yu Zhao, Wanxue Wang, Yiran Xie, Huating Wang, Yihua Yang
Endometrial cancer is the most common gynecologic malignancy, about 80% of which is endometrial endometrioid carcinoma. Dysregulation of spindle assembly checkpoint plays a vital role in endometrial endometrioid carcinoma tumorigenesis and progression. The purpose of this study was to explore how tyrosine threonine kinase, a spindle assembly checkpoint-related protein, promotes the endometrial endometrioid carcinoma progression. We found that both messenger RNA and protein levels of tyrosine threonine kinase in endometrial endometrioid carcinoma tissues are higher than those in normal endometrial tissues, and its expression is associated with tumor stages...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28712776/clonal-evolution-in-paired-endometrial-intraepithelial-neoplasia-atypical-hyperplasia-and-endometrioid-adenocarcinoma
#3
Mariano Russo, James Broach, Kathryn Sheldon, Kenneth R Houser, Dajiang J Liu, Joshua Kesterson, Rebecca Phaeton, Carrie Hossler, Nadine Hempel, Maria Baker, Jordan M Newell, Richard Zaino, Joshua I Warrick
Endometrial intraepithelial neoplasia (EIN) and atypical endometrial hyperplasia (AH) are histomorphologically-defined precursors to endometrioid adenocarcinoma, which are unified as EIN/AH by the World Health Organization. EIN/AH harbors a constellation of molecular alterations similar those found in endometrioid adenocarcinoma. However, the process of clonal evolution from EIN/AH to carcinoma is poorly characterized. To investigate, we performed next generation sequencing, copy number alteration (CNA) analysis, and immunohistochemistry for mismatch repair protein expression on EIN/AH and endometrioid adenocarcinoma samples from 6 hysterectomy cases with spatially distinct EIN/AH and carcinoma...
July 13, 2017: Human Pathology
https://www.readbyqxmd.com/read/28709703/extent-of-lymphovascular-space-invasion-may-predict-lymph-node-metastasis-in-uterine-serous-carcinoma
#4
Yushen Qian, Erqi L Pollom, Chika Nwachukwu, Kira Seiger, Rie von Eyben, Ann K Folkins, Elizabeth A Kidd
OBJECTIVES: Emerging evidence suggests that extent of lymphovascular space invasion (LVSI) predicts for risk of lymph node metastasis in endometrioid uterine cancers. However, this correlation remains unknown in the setting of uterine serous carcinoma (USC). We sought to examine the association between extent of LVSI and other histopathologic characteristics with risk of nodal metastasis for women with USC. MATERIALS/METHODS: Pathological data from all cases of uterine serous carcinoma between July 1998 to July 2015 at our institution were reviewed...
July 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28700436/malignant-female-adnexal-tumor-of-probable-wolffian-origin-case-report-and-literature-review
#5
Shuhui Hong, Jing Cui, Li Li, Joseph Buscema, Casandra Liggins, Wenxin Zheng
Although most female adnexal tumors of probable Wolffian origin have a benign biologic behavior, occasional cases have exhibited malignant potential. We encountered a 50-yr-old woman with an uncommon female adnexal tumors of probable Wolffian origin, which involved bilateral ovaries, invaded the ipsilateral fallopian tube, and extended to the uterine serosa. The initial histopathologic presentation caused significant confusion in pathologic diagnosis. Multiple differential diagnoses including ovarian endometrioid carcinoma, Sertoli cell tumor, and metastasis from nongynecologic organs were considered...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28700425/ultrastaging-of-sentinel-lymph-nodes-in-endometrial-carcinoma-according-to-use-of-2-different-methods
#6
Elizabeth Euscher, Dawen Sui, Pamela Soliman, Shannon Westin, Preetha Ramalingam, Roland Bassett, Anais Malpica
Sentinel lymph node (SLN) sampling may provide staging information without exposing patients to risks of lymph node dissection. There is no consensus protocol for optimal pathologic handling of these specimens. This study compares 2 ultrastaging protocols of SLN in endometrial carcinoma (EC). All SLN were serially sectioned perpendicular to the long axis in 2 mm intervals and entirely submitted for routine hematoxylin and eosin (H&E) processing. SLN negative by routine processing had ultrastaging (US) by one of the following: method 1 (M1), 5 H&E levels at 250 μm intervals with 2 unstained slides at each level; pankeratin immunohistochemistry (IHC) performed on level 1 in cases with negative H&E levels or method 2 (M2), 1 H&E level + 2 unstained slides cut 250 μm into the tissue block; pankeratin IHC performed in cases with negative H&E...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28678427/clear-cell-and-endometrioid-carcinomas-are-their-differences-attributable-to-distinct-cells-of-origin
#7
Dawn R Cochrane, Basile Tessier-Cloutier, Katherine M Lawrence, Tayyebeh Nazeran, Anthony N Karnezis, Clara Salamanca, Angela S Cheng, Jessica N McAlpine, Lien N Hoang, C Blake Gilks, David G Huntsman
Endometrial epithelium is the presumed tissue of origin for both eutopic and endometriosis-derived clear cell and endometrioid carcinomas. We had previously hypothesized that the morphological, biological and clinical differences between these carcinomas are due to histotype-specific mutations. Although some mutations and genomic landscape features are more likely to be found in one of these histotypes, we were not able to identify a single class of mutations that was exclusively present in one histotype and not the other...
July 5, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28673864/analysis-of-endometrial-carcinoma-in-young-women-at-a-high-volume-cancer-center
#8
Alper Biler, Ulas Solmaz, Selcuk Erkilinc, Mehmet Gokcu, Mustafa Bagci, Orhan Temel, Tugba Karadeniz, Muzaffer Sanci
OBJECTIVE: To investigate the clinicopathological characteristics, treatment, survival, and prognosis of endometrial cancer in women aged ≤40 years. METHODS: Women who underwent surgery for endometrial cancer at a single high-volume cancer center between January 1995 and December 2014 were retrospectively reviewed. Women aged >40, patients with missing data, and those who did not undergo surgical staging were excluded. Univariate and multivariate regression models were used to identify the risk factors for overall survival and progression-free survival...
June 30, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28669579/lessons-learnt-from-implementation-of-a-lynch-syndrome-screening-program-for-patients-with-gynaecological-malignancy
#9
Fedaa Najdawi, Ashley Crook, Jayne Maidens, Christopher McEvoy, Andrew Fellowes, Justine Pickett, Musei Ho, David Nevell, Kirsten McIlroy, Amy Sheen, Loretta Sioson, Mahsa Ahadi, John Turchini, Adele Clarkson, Russell Hogg, Sue Valmadre, Greg Gard, Susan J Dooley, Rodney J Scott, Stephen B Fox, Michael Field, Anthony J Gill
Despite a trend towards universal testing, best practice to screen patients presenting with gynaecological malignancy for Lynch syndrome (LS) is uncertain. We report our institutional experience of a co-ordinated gynaecological LS screening program. All patients with endometrial carcinoma or carcinosarcoma, or gynaecological endometrioid or clear cell carcinomas undergo reflex four panel immunohistochemistry (IHC) for MLH1, PMS2, MSH2 and MSH6 followed by cascade somatic hypermethylation analysis of the MLH1 promoter locus for dual MLH1/PMS2 negative tumours...
June 29, 2017: Pathology
https://www.readbyqxmd.com/read/28668894/expression-of-polypeptide-n-acetylgalactosaminyltransferase-6-in-epithelial-ovarian-carcinoma
#10
Midori Murakami, Seiji Kagami, Thuy Thi Nguyen, Chiho Koi, Tomoko Kurita, Toru Hachisuga
BACKGROUND: The family of polypeptide N-acetylgalactosanimyltransferases (GalNAc-Ts) are important factors in glycosylation in carcinomas. The purpose of this study was to investigate the clinical significance of GalNAc-T6 and its correlation with the prognosis of epithelial ovarian carcinoma. MATERIALS AND METHODS: A total of 150 patients with epithelial ovarian carcinoma were enrolled and the relationship between GalNAc-T6 expression by immunohistochemistry and long-term survival was evaluated...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28667682/dedifferentiated-carcinoma-with-clear-cell-carcinoma-of-the-endometrium-a-case-report
#11
Seung Eun Lee, Ha Young Park, Seung-Hyuk Shim, Wook Youn Kim
Endometrial dedifferentiated carcinoma consists of a combination of undifferentiated and differentiated carcinomas. To date, clear cell carcinoma components in endometrial dedifferentiated carcinoma have not been reported. We report the first case of endometrial dedifferentiated carcinoma with clear cell carcinoma in a 58-year-old woman. The uterine corpus was completely replaced and enlarged by a heterogeneous mass. The endometrial cut surface showed a yellowish papillary growing mass involving endometrium and deeper myometrium...
June 30, 2017: Pathology International
https://www.readbyqxmd.com/read/28625395/l1cam-expression-associates-with-poor-outcome-in-endometrioid-but-not-in-clear-cell-ovarian-carcinoma
#12
Piret Soovares, Annukka Pasanen, Ralf Bützow, Heini Lassus
OBJECTIVE: Our aim was to study the expression of L1CAM in endometrioid and clear cell ovarian carcinomas and to evaluate its correlation with clinical parameters and patient prognosis. METHODS: Tissue microarray -based immunohistochemical analysis of L1CAM expression was performed in 249 endometrioid and 140 clear cell ovarian carcinomas. Concurrent endometrial carcinoma was found in 57 of these patients. RESULTS: L1CAM expression was found in 15% of endometrioid and 23% of clear cell ovarian carcinomas...
June 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28614200/priority-for-description-of-the-melf-pattern-of-myoinvasive-endometrioid-carcinoma
#13
Shawn K Murray, Robert H Young
No abstract text is available yet for this article.
August 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28604451/is-tumor-size-really-important-for-prediction-of-lymphatic-dissemination-in-grade-1-endometrial-carcinoma-with-superficial-myometrial-invasion
#14
Murat Oz, Vakkas Korkmaz, Mehmet Mutlu Meydanli, Mustafa Erkan Sari, Zeliha Firat Cuylan, Tayfun Gungor
OBJECTIVES: Selection of patients with endometrioid endometrial cancer (EEC), in whom systematic lymph node dissection (LND) is indicated, is an important part of management to maintain optimal oncological outcomes, while avoiding unnecessary morbidities. According to the current approach, LND is recommended for the patients with International Federation of Gynecology and Obstetrics (FIGO) grade 1 to 2 tumors and a primary tumor diameter (PTD) greater than 2 cm, even with myometrial invasion (MMI) of less than 50%...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28604450/low-volume-lymph-node-metastases-in-endometrial-carcinoma
#15
Lani K Clinton, Jordan Kondo, Michael E Carney, Pamela Tauchi-Nishi, Keith Terada, David Shimizu
OBJECTIVE: The aim of this study was to determine the histopathologic characteristics of patients with endometrial carcinoma with low-volume metastases (micrometastases and isolated tumor cells) compared with macrometastases. METHODS: We performed a retrospective review of patients with endometrial carcinoma. RESULTS: Among 350 robotic-assisted hysterectomies for endometrial cancer, 187 (53%) underwent attempted sentinel lymph node (SLN) biopsy...
July 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28601659/endometrioid-endometrial-carcinomas-with-melf-type-of-myoinvasion-role-of-immunohistochemistry-in-the-detection-of-occult-lymph-node-metastases-and-their-clinical-significance
#16
Iñigo Espinosa, Neus Serrat, Gian Franco Zannoni, Ramón Rovira, Emanuela D'Angelo, Jaime Prat
In endometrioid endometrial carcinomas (EEC), MELF (microcystic, elongated and fragmented) myoinvasion is associated with easily overlooked lymph node metastases; however, the role of immunohistochemistry in their detection and their clinical significance have not been addressed. We identified MELF in 43 of 101 (43%) myoinvasive EECs. Nodes were removed in 49 (49%), 25 with MELF and 24 without MELF. Metastases were initially reported in 3 of the former (12%) and 2 of the latter (8%). All negative nodes were reviewed and cytokeratin immunohistochemistry was performed...
June 7, 2017: Human Pathology
https://www.readbyqxmd.com/read/28593716/does-an-epidemiological-comparison-support-a-common-cellular-lineage-for-similar-subtypes-of-postmenopausal-uterine-and-ovarian-carcinoma-the-norwegian-women-and-cancer-study
#17
Mie Jareid, Idlir Licaj, Karina Standahl Olsen, Eiliv Lund, Hege M Bøvelstad
Uterine and ovarian carcinomas have the same major histological subtypes, but whether they originate from the same cell types is a matter of ongoing debate. Uterine and ovarian endometrioid and clear cell carcinoma (ECC) and uterine and ovarian serous carcinoma (SC) may originate in the same location, or share a common lineage of differentiation. Epidemiologically, a common cellular lineage should be reflected in similar risk associations, and we explored the similarity of uterine and ovarian ECC and uterine and ovarian SC...
June 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28582347/tissue-based-immunohistochemical-biomarker-expression-in-malignant-glandular-lesions-of-the-uterine-cervix-a-systematic-review
#18
Sandra Lee, Vikrant V Sahasrabuddhe, Diana Mendoza-Cervantes, Rachel Zhao, Máire A Duggan
Literature published between 1975 and 2015 was systematically reviewed to conduct a case-comparator study of tissue based, immunohistochemical biomarker expression among malignant glandular histotypes of the uterine cervix so as to identify differences that could have diagnostic utility. Of the 902 abstracts, 154 articles had a full review, and 52 were included. Biomarker positivity in cases of adenocarcinoma in situ (AIS) were compared with atypical lobular endocervical glandular hyperplasia and invasive histotypes grouped as mucinous, endometrioid, adenosquamous, serous clear cell, minimal deviation-gastric type, and mesonephric carcinomas (7 AIS case-comparators)...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28582346/endometrial-carcinoma-with-trophoblastic-components-clinicopathologic-analysis-of-a-rare-entity
#19
Kojo R Rawish, Natalia Buza, Wenxin Zheng, Oluwole Fadare
Somatic endometrial carcinomas with trophoblastic components have only rarely been described. To better characterize this distinctive combination of histotypes, we report herein 4 new cases, representing the largest cohort reported thus far, and review previously reported cases. The 4 new patients ranged in age from 61 to 77 yr (mean, 68 yr). The first patient had a grade 2 endometrioid carcinoma, surgical International Federation of Gynecology and Obstetrics stage IA, that recurred 5 months later at the vaginal apex with purely choriocarcinoma elements, suggestive of unsampled trophoblastic areas in the uterus...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28582344/androgen-receptor-expression-in-endometrial-carcinoma
#20
Sara L Zadeh, Linda R Duska, Anne M Mills
Endometrial carcinoma (ECA) is frequently hormonally driven and can be treated with endocrine-based therapy, yet hormone receptor status is not routinely assessed. In particular, little is known about the significance of androgen receptor (AR) in ECA. Androgen has antiproliferative effects in the healthy endometrium and could serve a similar role to progesterone in curbing the progression of estrogen-dependent neoplasia. There may also be a subset of ECA that benefits from androgen antagonistic therapy. We herein investigate AR expression across ECA subtypes and compare its expression to estrogen receptor (ER) and progesterone receptor (PR)...
June 2, 2017: International Journal of Gynecological Pathology
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