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https://www.readbyqxmd.com/read/29678523/safety-and-efficacy-of-mesenchymal-stem-cells-for-radiation-induced-xerostomia-a-randomized-placebo-controlled-phase-1-2-trial-mesrix
#1
Christian Grønhøj, David H Jensen, Peter Vester-Glowinski, Siri Beier Jensen, Allan Bardow, Roberto S Oliveri, Lea Munthe Fog, Lena Specht, Carsten Thomsen, Sune Darkner, Michael Jensen, Vera Müller, Katalin Kiss, Tina Agander, Elo Andersen, Anne Fischer-Nielsen, Christian von Buchwald
BACKGROUND: Salivary gland hypofunction and xerostomia are major complications to head and neck radiotherapy. This trial assessed the safety and efficacy of adipose tissue-derived mesenchymal stem cell (ASC) therapy for radiation-induced xerostomia. PATIENT AND METHODS: This randomized, placebo-controlled phase 1/2 trial included 30 patients, randomized in a 1:1 ratio to receive ultrasound-guided transplantation of ASCs or placebo to the submandibular glands. Patients had previously received radiotherapy for a T1-2, N0-2A, human papillomavirus-positive, oropharyngeal squamous cell carcinoma...
March 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29676714/-does-ovarian-cancer-start-in-the-fallopian-tubes-possible-implications-for-preventive-adnexal-removal
#2
M P Steenbeek, J Bulten, N Hoogerbrugge, L F A G Massuger, J M A Pijnenborg, J A de Hullu
BACKGROUND: Recent insights in high-grade serous ovarian cancer development are pointing to the fallopian tubes as likely place of origin and not the ovaries themselves. This may have consequences for patients with increased risk of ovarian cancer. Adnexal removal is currently recommended for this patient group at an age of 35-45, which leads to premature menopause. CASE DESCRIPTION: In a 55-year-old woman with a BRCA1 germ line mutation, a high-grade serous carcinoma was unexpectedly diagnosed in both fallopian tubes during preventive adnexal removal...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29675469/noninvasive-ovarian-cancer-biomarker-detection-via-an-optical-nanosensor-implant
#3
Ryan M Williams, Christopher Lee, Thomas V Galassi, Jackson D Harvey, Rachel Leicher, Maria Sirenko, Madeline A Dorso, Janki Shah, Narciso Olvera, Fanny Dao, Douglas A Levine, Daniel A Heller
Patients with high-grade serous ovarian carcinoma (HGSC) exhibit poor 5-year survival rates, which may be significantly improved by early-stage detection. The U.S. Food and Drug Administration-approved biomarkers for HGSC-CA-125 (cancer antigen 125) and HE4 (human epididymis protein 4)-do not generally appear at detectable levels in the serum until advanced stages of the disease. An implantable device placed proximal to disease sites, such as in or near the fallopian tube, ovary, uterine cavity, or peritoneal cavity, may constitute a feasible strategy to improve detection of HGSC...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29671892/frequent-loss-of-claudin-4-expression-in-dedifferentiated-and-undifferentiated-endometrial-carcinomas
#4
Basile Tessier-Cloutier, Robert A Soslow, Colin J R Stewart, Martin Köbel, Cheng-Han Lee
INTRO: Dedifferentiated/undifferentiated endometrial carcinomas (DDEC/UEC) are aggressive endometrial cancers with frequent genomic inactivation of core components of switch/sucrose non-fermentable (SWI/SNF) complex proteins. Claudin-4, an epithelial intercellular tight junction protein was recently found to be expressed in SWI/SNF-deficient undifferentiated carcinomas but not SWI/SNF-deficient sarcomas. The aim of this study is to examine claudin-4 expression in UEC/DDEC and other high-grade uterine carcinomas...
April 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29668586/combination-of-serum-ca19-9-and-ca125-levels-and-contrast-enhanced-ultrasound-parametric-data-facilitates-to-differentiate-ovarian-serous-carcinoma-from-ovarian-malignant-epithelial-cancer
#5
Wei Zhang, Liying Wang, Zhongqiu Xin
Ovarian serous carcinoma (OSC) is semimalignant ovarian tumors that localized in the ovary at the initial presentation, and can be surgically resected in an excellent prognosis. In contrast, surgical treatment plus adjuvant chemotherapy for ovarian malignant epithelial cancer (OMEC) is the standard treatment stratagem that is painful with poor prognosis and cost quite expensively. Thus, the accurate preoperative differentiation of OSC from OMEC is important for determining the treatment methods and decreasing the cost for individual patients...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29665453/can-concurrent-high-risk-endometrial-carcinoma-occur-with-atypical-endometrial-hyperplasia
#6
Baki Erdem, Osman Aşıcıoğlu, Niyazi Alper Seyhan, Nuri Peker, Volkan Ülker, Özgür Akbayır
BACKGROUND: This study investigated the frequency of high-risk cancer types in hysterectomy material obtained from patients who were diagnosed with atypical endometrial hyperplasia (AEH) by endometrial sampling. MATERIALS AND METHODS: A total of 227 patients with AEH were retrospectively included in the study. Hysterectomy material was examined as both perioperative frozen section (FS) and paraffin-embedded permanent section (PS). Grade III tumors, grade II tumors larger than 2 cm, over 50% myometrial invasion, cervical involvement, and serous or clear cell histology were considered high-risk...
April 14, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29662727/paratesticular-serous-papillary-carcinoma-of-high-grade-and-malignant-potential-a-rare-case-with-a-role-for-adjuvant-therapy
#7
Jacob Lifton, Saum Ghodoussipour, Guang-Qian Xiao, Tanya Dorff, Jeffrey Loh-Doyle, Stuart D Boyd
Paratesticular serous papillary carcinomas are very rare, with less than 40 cases reported in the literature. These neoplasms are Müllerian in origin, and more commonly seen as epithelial-type ovarian cancer. Given the rarity of this tumor in men, staging and recommended treatment options do not exist. Herein, we present the case of a 35-year-old male with high-grade invasive serous papillary carcinoma. He was diagnosed after left radical orchiectomy for paratesticular mass and subsequently treated with adjuvant chemotherapy according to existing recommendations for its ovarian counterpart...
February 13, 2018: Curēus
https://www.readbyqxmd.com/read/29662608/wt1-p53-and-p16-expression-in-the-diagnosis-of-low-and-high-grade-serous-ovarian-carcinomas-and-their-relation-to-prognosis
#8
Luis Felipe Sallum, Liliana Andrade, Susana Ramalho, Amanda Canato Ferracini, Rodrigo de Andrade Natal, Angelo Borsarelli Carvalho Brito, Luis Otávio Sarian, Sophie Derchain
Objective: To evaluate the diagnostic and prognostic value of the immunohistochemical expression of WT1, p53 and p16 in low- (LGSOCs) and high-grade serous ovarian carcinomas (HGSOCs). Results: HGSOC had a significantly higher proportion of advanced stage disease, higher CA125 levels, higher proportion of post-surgery residual disease and higher recurrence or disease progression. WT1 was expressed in 71.4% of LGSOCs and in 57.1% of HGSOCs ( p = 0.32). Focal and/or complete absence of p53 expression with negative p16 expression was found in 90...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29661166/high-ox40-expression-in-recurrent-ovarian-carcinoma-is-indicative-for-response-to-repeated-chemotherapy
#9
Michaela Ramser, Simone Eichelberger, Silvio Däster, Benjamin Weixler, Marko Kraljević, Robert Mechera, Athanasios Tampakis, Tarik Delko, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Raoul A Droeser, Gad Singer
BACKGROUND: Ovarian carcinoma (OC) is the fifth most common female cancer and mostly diagnosed at an advanced stage. Surgical debulking is usually followed by adjuvant platinum-based chemotherapy. Only few biomarkers are known to be related to chemosensitivity. OX40 is a TNF receptor member and expressed on activated CD4+ and CD8+ T cells. It is known that OX40 signaling promotes survival and responds to various immune cells of the innate and adaptive immune system. Therefore we investigated the indicative value of OX40 expression for recurrence and survival in OC...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29660830/cytologic-diagnosis-of-primary-peritoneal-high-grade-serous-carcinoma-in-a-man
#10
Brandon Umphress, John Philip, Yaxia Zhang, Xiaoqi Lin
Primary peritoneal serous carcinoma (PPSC) is a rare neoplasm histologically indistinguishable from ovarian serous carcinoma primarily occurring in the female population. To date, extremely rare cases of PPSC have been reported in men; however, diagnosis by cytology has yet to be described. Here we present the clinical, radiographic, cytomorphologic, histologic and immunohistochemical (IHC) findings of a high-grade (HG) PPSC in a 70-year-old man with a history of prostatic adenocarcinoma. Core needle biopsy (CNB) touch preparation smears showed pleomorphic, round, columnar and polygonal epithelioid cells present singly or arranged in loosely cohesive three-dimensional clusters...
April 16, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29651149/author-correction-crispr-cas9-derived-models-of-ovarian-high-grade-serous-carcinoma-targeting-brca1-pten-and-nf1-and-correlation-with-platinum-sensitivity
#11
Josephine B Walton, Malcolm Farquharson, Susan Mason, Jennifer Port, Bjorn Kruspig, Suzanne Dowson, David Stevenson, Daniel Murphy, Martin Matzuk, Jaeyeon Kim, Seth Coffelt, Karen Blyth, Iain A McNeish
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650839/-a-case-of-splenic-metastasis-from-serous-surface-papillary-carcinoma-of-the-peritoneum-treated-by-laparoscopic-splenectomy
#12
Yongkook Kim, Tomoki Hata, Takayuki Ogino, Hiromitsu Hoshino, Junji Kawada, Miho Okano, Masaki Okuyama, Takeshi Yokoi, Masaru Yamasaki, Toshimasa Tsujinaka
A 50-year-old woman with abdominal fullness, lower abdominal pain, elevated serum CA125, and ascites, underwent neoadjuvant chemotherapy with 6 courses of PTX/CBDCA followed by total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and intrapelvic peritoneal stripping based on a diagnosis of serous surface papillary carcinoma(SSPC) of the peritoneum. Complete response(CR)was shown after adjuvant chemotherapy with 3 courses of the same regimen. After 6 months, serum CA125 level re-increased and abdominal CT showed small low density areas in the patient's spleen and the perisplenic fat tissue...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29626374/cleaved-caspase-3-expression-is-a-potential-prognostic-factor-for-endometrial-cancer-with-positive-peritoneal-cytology
#13
Naoki Ogane, Masanori Yasuda, Hisamori Kato, Tomomi Kato, Mitsutake Yano, Yoichi Kameda, Shingo Kamoshida
OBJECTIVE: Positive peritoneal cytology (PPC) in endometrial cancer remains a controversial topic. Cleaved caspase-3 (CC3) and Ki-67 are excellent markers of apoptotic and proliferating cells, respectively. The objective of this study was to determine the significance of CC3 and Ki-67 expression in peritoneal cytology samples as prognostic factors for endometrial cancer with PPC. METHODS: Sixty endometrial cancer specimens with PPC alone were divided into 51 endometrioid tumours (43 endometrioid carcinomas and 8 carcinomas with squamous differentiation) and 9 non-endometrioid tumours (2 serous carcinomas, 3 clear cell carcinomas, and 4 carcinosarcomas)...
April 6, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29626062/trastuzumab-extends-progression-free-survival-in-her2-neu-uterine-tumors
#14
(no author information available yet)
Adding trastuzumab to carboplatin-paclitaxel is well tolerated in patients with uterine serous carcinoma.
April 6, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29623583/pathology-findings-and-clinical-outcomes-after-risk-reduction-salpingo-oophorectomy-in-brca-mutation-carriers-a-multicenter-spanish-study
#15
L Minig, S Cabrera, R Oliver, A Couso, M J Rubio, S Iacoponi, M B Martin-Salamanca, S Carballo-Rastrilla, J M Cádenas-Rebollo, A García-Garcia, B Gil-Ibáñez, M J Juan-Fita, M G Patrono
OBJECTIVE: To determine the incidence of serous tubal intraepithelial carcinoma (STIC) after risk reduction salpingo-oophorectomy(RRSO), and to describe oncological outcomes after RRSO. MATERIALS AND METHODS: BRCA pathogenic mutation carriers who had undergone an RRSO were evaluated in this retrospective multicenter observational study. Patients were only included when fallopian tubes were analyzed following the protocol for Sectioning and Extensively Examining the FIMbria (SEE-FIM)...
April 5, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29621127/prognostic-factors-of-uterine-serous-carcinoma-a-multicenter-study
#16
Xiaozhu Zhong, Jianliu Wang, Tengen Kaku, Zhiqi Wang, Xiaoping Li, Lihui Wei
BACKGROUND: The prognostic factors of uterine serous carcinoma (USC) vary among studies, and there is no report of Chinese USC patients. OBJECTIVE: The aim of this study was to investigate the clinicopathological characteristics and prognostic factors in Chinese patients with USC. METHODS: Patients with USC from 13 authoritative university hospitals in China and treated between 2004 and 2014 were retrospectively reviewed. Three-year disease-free survival rate (DFSR), cumulative recurrence, and cumulative mortality were estimated by Kaplan-Meier analyses and log-rank tests...
April 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29621126/examining-survival-outcomes-of-852-women-with-advanced-ovarian-cancer-a-multi-institutional-cohort-study
#17
Taymaa May, Alon Altman, Jacob McGee, Lin Lu, Wei Xu, Kelly Lane, Prafull Ghatage, Barry Rosen
INTRODUCTION: This study examines patterns of clinical practice in the management of women with advanced high-grade serous ovarian carcinoma (HGSC). METHODS: A total of 852 patients with advanced HGSC were included in this retrospective cohort analysis. Patients underwent primary cytoreductive surgery (PCS) or neoadjuvant chemotherapy (NACT). Wilcoxon rank-sum test and χ test were applied. Univariate- and multivariate-analyses were performed, and survival outcomes were measured using Kaplan-Meier curves...
April 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29621081/odontogenic-keratocysts-as-first-manifestation-of-nevoid-basal-cell-carcinoma-syndrome-surgical-management-and-immunohistochemical-analysis
#18
Jessica Luana Dos Santos, Renata Zoraida Rizental Delgado, Greison Rabelo de Oliveira, Ana Lúcia Carrinho Ayroza Rangel
Nevoid Basal Cell Carcinoma Syndrome (NBCCS), also known as Gorlin syndrome, is a rare autosomal dominant disorder, with no gender predilection. Individuals with NBCCS are commonly diagnosed between 17 and 35 years old and can present multiple basal cell carcinomas scattered throughout the body, presence of recurrent and early-onset odontogenic keratocysts (OKCs) and skeletal abnormalities. This article describes a case of a 13-year-old white boy who referred complaining of facial asymmetry. Extraoral examination revealed volumetric increase displacing the nasal ala from the right side and extended to the zygomatic bone...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29620582/radiation-associated-angiosarcoma-mimicking-fallopian-tube-high-grade-serous-carcinoma-in-a-woman-with-de-novo-li-fraumeni-syndrome
#19
Sarah M Crafton, Leigha Senter-Jamieson, James L Chen, Larry J Copeland, Adrian A Suarez
We present a case study of a woman with history of rectal adenocarcinoma, and a new diagnosis of radiation-associated angiosarcoma mimicking fallopian tube high-grade serous carcinoma who was subsequently found to have de novo Li-Fraumeni syndrome. Our objective is to highlight angiosarcoma as a potential pitfall in the diagnosis of high-grade serous carcinoma.
April 3, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29620581/coexistence-of-braf-v600e-and-tert-promoter-mutations-in-low-grade-serous-carcinoma-of-ovary-recurring-as-carcinosarcoma-in-a-lymph-node-report-of-a-case
#20
Mahkam Tavallaee, David F Steiner, James L Zehnder, Ann K Folkins, Amer K Karam
Low-grade serous carcinomas only rarely coexist with or progress to high-grade tumors. We present a case of low-grade serous carcinoma with transformation to carcinosarcoma on recurrence in the lymph node. Identical BRAF V600E and telomerase reverse transcriptase promoter mutations were identified in both the original and recurrent tumor. Given that telomerase reverse transcriptase promotor mutations are thought to play a role in progression of other tumor types, the function of telomerase reverse transcriptase mutations in BRAF mutated low-grade serous carcinoma deserves investigation...
April 3, 2018: International Journal of Gynecological Pathology
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