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https://www.readbyqxmd.com/read/28635231/-comparison-of-paired-box-genes-8-and-2-expression-in-epithelium-tissues-and-the-related-tumors
#1
Y Song, X Huang, G H Shen, X Y Liu, X Zhang
Objective: To explore the expressional differences between paired box genes 2(Pax2) and 8 (Pax8) protein in different kinds of epitheliums and tumors, and to investigate the clinicopathologic significance. Methods: Expression levels of Pax2 and Pax8 protein were detected in 75 cases of different human epithelium tissues and 255 cases of different tumors on tissue microarray by immunohistochemistry. Results: Pax2 and Pax8 selectively expressed in different tissues. The positive rates of Pax8 protein expressed in the normal epithelium of the thyroid, urinary system and female reproductive system were 100% (2/2), 60...
June 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28631711/-expansion-of-secretory-cells-in-the-fallopian-tubal-epithelium-in-the-early-stages-of-the-pathogenesis-of-ovarian-serous-carcinomas
#2
A V Asaturova, L S Ezhova, N M Faizullina, L V Adamyan, G N Khabas, M V Sannikova
AIM: to investigate the frequency of the types of fallopian tubal secretory cell expansion (SCE) in diseases of the reproductive organs and to determine the immunophenotype and biological role of the cells in the early stages of the pathogenesis of high-grade ovarian serous carcinomas (HGOSC). SUBJECTS AND METHODS: The investigation enrolled 287 patients with extraovarian diseases and ovarian serous tumors varying in grade, whose fallopian tubes were morphologically and immunohistochemically examined using p53, Ki-67, PAX2, Bcl-2, beta-catenin, and ALDH1 markers...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28631655/erratum-squash-cytodiagnosis-of-synchronous-papillary-serous-carcinoma-of-ovary-and-endometrium-with-demonstration-of-serous-tubal-intraepithelial-carcinoma-as-a-precursor-lesion
#3
(no author information available yet)
[This corrects the article DOI: 10.4103/0377-4929.200039].
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28628712/hyperthermic-intraperitoneal-chemoperfusion-as-a-component-of-multimodality-therapy-for-ovarian-and-primary-peritoneal-cancer
#4
Deepa Magge, Lekshmi Ramalingam, Yongli Shuai, Robert P Edwards, James F Pingpank, Steven S Ahrendt, Matthew P Holtzman, Herbert J Zeh, David L Bartlett, Haroon A Choudry
BACKGROUND AND OBJECTIVES: The role of hyperthermic intraperitoneal chemoperfusion (HIPEC) in the multimodality treatment of ovarian peritoneal metastases (OPM) and primary peritoneal cancer (PPC) remains controversial. We hypothesized that cytoreductive surgery (CRS) and HIPEC would provide meaningful survival benefit without excessive morbidity. METHODS: We reviewed clinicopathologic and perioperative data following 96 CRS-HIPEC procedures for primary or recurrent OPM and PPC...
June 19, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28626402/effect-of-the-combination-of-trabectedin-and-pegylated-liposomal-doxorubicin-in-a-brca2-mutation-carrier-with-recurrent-platinum-sensitive-ovarian-cancer
#5
María Jesús Rubio Pérez
INTRODUCTION: The current standard of care for ovarian cancer is optimal cytoreduction with adjuvant chemotherapy based on a platinum/taxane combination. Although the response rate to this therapy is high, most patients ultimately relapse. Response to second-line therapy and prognosis are linked to the platinum-free interval (PFI); when both improve, the PFI increases. As a result, there is an increasing interest in the PFI extension strategies including platinum-free combinations. CASE PRESENTATION: A 50-year-old postmenopausal woman presented with ovarian serous carcinoma with peritoneal carcinomatosis...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28625311/cancers-de-l%C3%A2-ovaire-brca-mut%C3%A3-consultation-d%C3%A2-oncog%C3%A3-n%C3%A3-tique-et-prescription-des-inhibiteurs-de-parp
#6
Laurence Gladieff, Dominique Stoppa Lyonnet, Alain Lortholary, Alexandra Leary, Catherine Genestie, Isabelle Ray-Coquard
GENETIC COUNSELING AND PARP INHIBITORS PRESCRIPTION: Upon the availability of the PARP inhibitors in relapsed ovarian carcinoma, the pathways of the oncogenetic counseling were modified. Any research for a constitutional alteration of the BRCA1 and BRCA2 genes must be accompanied by an oncogenetic counseling. BRCA testing is recommended from the diagnosis to every woman with an ovarian or fallopian tube or peritoneum of high grade adenocarcinoma, whatever the age at the diagnosis and her family history. In case of sensitive relapse or potential inclusion in a clinical trial and in the absence of preliminary constitutional research, the oncogenetic counseling is organized according to a fast track pathway and a somatic analysis can be realized in parallel...
May 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28623900/characterization-of-microrna-200-pathway-in-ovarian-cancer-and-serous-intraepithelial-carcinoma-of-fallopian-tube
#7
Junzheng Yang, Yilan Zhou, Shu-Kay Ng, Kuan-Chun Huang, Xiaoyan Ni, Pui-Wah Choi, Kathleen Hasselblatt, Michael G Muto, William R Welch, Ross S Berkowitz, Shu-Wing Ng
BACKGROUND: Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst formation and tumor invasion. The purpose of this study was to determine if the miR-200 pathway is involved in the early stages of ovarian cancer pathogenesis by studying the expression levels of the pathway components in a panel of clinical ovarian tissues, and fallopian tube tissues harboring serous tubal intraepithelial carcinomas (STICs), a suggested precursor lesion for high-grade serous tumors...
June 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28616156/primary-solitary-peritoneal-tumor-of-the-abdominal-wall-report-of-a-rare-case-and-review-of-the-literature
#8
Christoforos Efthimiadis, Aristeidis Ioannidis, Konstantinia Kofina, Marios Grigoriou
Abdominal wall tumors are sometimes diagnosed as metastases of ovarian cancer, however, primary peritoneal tumors should be taken into consideration in the final diagnosis. A 49-year-old female patient was admitted in our Department for the excision of a pulpable abdominal wall lump, with no other abnormalities shown on imaging investigation. On histology examination, the excised specimen revealed characteristics of metastatic high-grade serous ovarian carcinoma. Total hysterectomy, bilateral oophorectomy, omentectomy and appendectomy were performed...
June 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28608929/high-grade-serous-carcinomas-arise-in-the-mouse-oviduct-via-defects-linked-to-the-human-disease
#9
Yali Zhai, Rong Wu, Rork Kuick, Michael S Sessine, Stephanie Schulman, Megan Green, Eric R Fearon, Kathleen R Cho
Recent studies suggest that the most common and lethal type of "ovarian" cancer, high-grade serous carcinoma (HGSC), usually arises from epithelium on the fallopian tube fimbriae, and not from the ovarian surface epithelium (OSE). We have developed Ovgp1-iCreER(T2) mice in which the Ovgp1 promoter controls expression of tamoxifen (TAM)-regulated Cre recombinase in oviductal epithelium - the murine equivalent of human fallopian tube epithelium (FTE). We employed Ovgp1-iCreER(T2) mice to show that FTE-specific inactivation of several different combinations of tumour suppressor genes recurrently mutated in human HGSCs - namely Brca1, Trp53, Rb1, and Nf1 - results in serous tubal intraepithelial carcinomas (STICs) that progress to HGSC or carcinosarcoma, and to widely metastatic disease in a subset of mice...
June 13, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28606125/age-is-associated-with-prognosis-in-serous-ovarian-carcinoma
#10
Fei Deng, Xia Xu, Mengmeng Lv, Binhui Ren, Yan Wang, Wenwen Guo, Jifeng Feng, Xiaoxiang Chen
PURPOSE: The survival duration of elderly patients with epithelial ovarian carcinoma is shorter than that of their younger counterparts. This variation in survival duration is likely attributed to differences in the distribution of histological type or grade, International Federation of Gynecology and Obstetrics (FIGO) staging, and undertreatment, but this observation remains controversial. This study aimed to investigate the biological factors other than selection bias associated with the decreased survival of elderly patients with ovarian carcinoma...
June 12, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28599499/comparative-secretome-of-ovarian-serous-carcinoma-gelsolin-in-the-spotlight
#11
Sandra Pierredon, Pascale Ribaux, Jean-Christophe Tille, Patrick Petignat, Marie Cohen
Ovarian cancer is one of the most common types of reproductive cancer, and has the highest mortality rate amongst gynecological cancer subtypes. The majority of ovarian cancers are diagnosed at an advanced stage, resulting in a five-year survival rate of ~30%. Early diagnosis of ovarian cancer has improved the five-year survival rate to ≥90%, thus the current imperative requirement is to identify biomarkers that would allow the early detection, diagnosis and monitoring of the progression of the disease, or of novel targets for therapy...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28593890/extremely-locally-advanced-ovarian-malignant-mixed-mullerian-tumor-in-37-years-old-female
#12
Gjorgji Jota, Radomir Gelevski, Zoran Karadzov, Redzep Selmani, Magdalena Genadieva-Dimitrova, Margarita Peneva, Vesna Jovanovska-Manevska
Ovarian carcinosarcomas, rare variant of ovarian carcinoma, composed of both carcinomatous and mesenchymal components, solid and/or cystic, fleshy and hemorrhagic, frequently spreading beyond the ovary, are treated with surgery and adjuvant chemotherapy according to the treatment principles of ovarian carcinomas due to the small number of reported cases and lack of randomized studies. We report a case of a 37-year-old woman with clinical signs of extremely locally advanced tumor of ovarian origin, infiltrating the lower left quadrant of the abdominal wall with necrosis of the covering skin...
March 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28593778/-current-figo-staging-classification-for-cancer-of-ovary-fallopian-tube-and-peritoneum
#13
I Šišovská, L Minář, M Felsinger, M Anton, M Bednaříková, J Hausnerová, E Jandáková, V Weinberger
INTRODUCTION: Pelvic high-grade serous carcinomas (HGSCs) include carcinoma of ovary, fallopian tube, and peritoneum. Five-year survival, irrespective of the stage, is between 35-40%. Most patients are diagnosed in advanced stages of the disease. The new revised and expanded dualistic model of ovarian carcinogenesis shows that type II tumors are composed for the most part of high-grade serous ovarian carcinoma, carcinosarcoma, undifferentiated carcinoma and can be further subdivided into morphologic and molecular subtypes...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28593716/does-an-epidemiological-comparison-support-a-common-cellular-lineage-for-similar-subtypes-of-postmenopausal-uterine-and-ovarian-carcinoma-the-norwegian-women-and-cancer-study
#14
Mie Jareid, Idlir Licaj, Karina Standahl Olsen, Eiliv Lund, Hege M Bøvelstad
Uterine and ovarian carcinomas have the same major histological subtypes, but whether they originate from the same cell types is a matter of ongoing debate. Uterine and ovarian endometrioid and clear cell carcinoma (ECC) and uterine and ovarian serous carcinoma (SC) may originate in the same location, or share a common lineage of differentiation. Epidemiologically, a common cellular lineage should be reflected in similar risk associations, and we explored the similarity of uterine and ovarian ECC and uterine and ovarian SC...
June 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28589906/loss-of-calponin-h1-confers-anoikis-resistance-and-tumor-progression-in-the-development-of-high-grade-serous-carcinoma-originating-from-the-fallopian-tube-epithelium
#15
Kai-Hung Wang, Sung-Chao Chu, Tang-Yuan Chu
Increasing evidence indicates that ovarian high-grade serous carcinoma (HGSC) originates from the fallopian tube epithelium and metastasizes to the ovary as the secondary site. A working hypothesis is that detached tubal HGSC cells survive anoikis and implant on the ovary. In this study, we found that downregulation of calponin h1 (CNN1) is necessary for the anoikis survival and cell transformation. CNN1 was progressively downregulated in cells and tissues representing different stages of HGSC development from fallopian tube epithelium (FTE)...
May 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28582347/tissue-based-immunohistochemical-biomarker-expression-in-malignant-glandular-lesions-of-the-uterine-cervix-a-systematic-review
#16
Sandra Lee, Vikrant V Sahasrabuddhe, Diana Mendoza-Cervantes, Rachel Zhao, Máire A Duggan
Literature published between 1975 and 2015 was systematically reviewed to conduct a case-comparator study of tissue based, immunohistochemical biomarker expression among malignant glandular histotypes of the uterine cervix so as to identify differences that could have diagnostic utility. Of the 902 abstracts, 154 articles had a full review, and 52 were included. Biomarker positivity in cases of adenocarcinoma in situ (AIS) were compared with atypical lobular endocervical glandular hyperplasia and invasive histotypes grouped as mucinous, endometrioid, adenosquamous, serous clear cell, minimal deviation-gastric type, and mesonephric carcinomas (7 AIS case-comparators)...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28582344/androgen-receptor-expression-in-endometrial-carcinoma
#17
Sara L Zadeh, Linda R Duska, Anne M Mills
Endometrial carcinoma (ECA) is frequently hormonally driven and can be treated with endocrine-based therapy, yet hormone receptor status is not routinely assessed. In particular, little is known about the significance of androgen receptor (AR) in ECA. Androgen has antiproliferative effects in the healthy endometrium and could serve a similar role to progesterone in curbing the progression of estrogen-dependent neoplasia. There may also be a subset of ECA that benefits from androgen antagonistic therapy. We herein investigate AR expression across ECA subtypes and compare its expression to estrogen receptor (ER) and progesterone receptor (PR)...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28579069/serous-carcinoma-of-the-testicle-and-paratesticular-tissue-case-report-and-literature-review
#18
Garrison F Pease, Pauline M Chou
Ovarian-type epithelial lesions of the testicle and paratesticular tissue are uncommon, especially invasive serous adenocarcinoma with just 18 cases reported in the literature. While the majority of these tumors occur in adults with an age range from 16 to 87 years, just one patient was less than 10 years old. Herein, we report only the second case of invasive serous adenocarcinoma occurring in first decade of life, that of a 7 year-old boy. Additionally, clinical presentation, imaging, histopathology, immunohistochemistry, and clinical follow-up of invasive serous adenocarcinoma of the testicle are discussed along with review of the literature...
June 1, 2017: Urology
https://www.readbyqxmd.com/read/28574932/vascular-endothelial-growth-factor-vegf-polymorphisms-and-serum-vegf-levels-in-women-with-epithelial-ovarian-cancer-benign-tumors-and-healthy-ovaries
#19
Blanca González-Palomares, Pluvio J Coronado Martín, María Luisa Maestro de Las Casas, Silvia Veganzones de Castro, Sara Rafael Fernández, Marta Vidaurreta Lázaro, Virginia De la Orden García, Jose Antonio Vidart Aragon
OBJECTIVE: This study analyzed the relation of 5 single-nucleotide polymorphisms (SNPs) in the VEGF (vascular endothelial growth factor) gene in patients with epithelial ovarian cancer (EOC), compared with patients carrying benign tumors or healthy ovaries. We studied serum VEGF levels and the relation with SNPs and association between VEGF SNPs and haplotypes with progression-free survival (PFS) in patients with cancer. METHODS: The genotyping of VEGF gene polymorphisms (-2578 C/A, -1154 G/A, -460 T/C, +405 G/C, +936 C/T) was performed in DNA isolated from blood samples of 100 women...
June 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28571149/vegf-expression-to-support-targeted-therapy-in-ovarian-surface-epithelial-neoplasms
#20
Sudeshna Mukherjee, Mallika Pal, Susmita Mukhopadhyay, Indranil Das, Rathin Hazra, Suman Ghosh, Rajib Kumar Mondal, Runa Bal
INTRODUCTION: Vascular Endothelial Growth Factor (VEGF), a promoter of angiogenesis, is a promising target for anti-angiogenic therapy in ovarian cancer. In our study, we examined the expression of VEGF in the spectrum of epithelial ovarian neoplasms (benign, borderline and malignant) by Immunohistochemistry (IHC). AIM: Diagnosing ovarian epithelial neoplasms, examining the expression of VEGF in benign, borderline and malignant neoplasms and correlating it with histological grade and stage of malignant cases...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
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