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https://www.readbyqxmd.com/read/27761468/diabetic-macular-edema-pathophysiology-vasogenic-versus-inflammatory
#1
Pedro Romero-Aroca, Marc Baget-Bernaldiz, Alicia Pareja-Rios, Maribel Lopez-Galvez, Raul Navarro-Gil, Raquel Verges
Diabetic macular edema (DME) can cause blindness in diabetic patients suffering from diabetic retinopathy (DR). DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME. Although the vascular endothelial growth factor (VEGF) is known to play a role in the development of DME, the pathological processes leading to the onset of this disease are highly complex and the exact sequence in which they occur is still not completely understood. Angiogenesis and inflammation have been shown to be involved in the pathogenesis of this disease...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27668294/intimate-partner-violence-is-associated-with-increased-cd4-t-cell-activation-among-hiv-negative-high-risk-women
#2
Ameeta S Kalokhe, Chris C Ibegbu, Surinder P Kaur, Rama R Amara, Mary E Kelley, Carlos Del Rio, Rob Stephenson
BACKGROUND: Biological pathways mediating the link between intimate partner violence (IPV) and increased HIV risk remain unexplored. We hypothesized that IPV-induced stress negatively affects HIV systemic immune defenses and aimed to evaluate whether IPV was associated with immune profiles linked to HIV susceptibility: CD4 activation and diminished regulatory T-cell (Treg) frequency. METHODS: Seventy-five HIV-negative high-risk women were surveyed regarding their IPV experience...
2016: Pathogens & Immunity
https://www.readbyqxmd.com/read/27438733/-organization-of-medical-specialization-in-cervical-cancer-and-its-control-in-brazil-the-instituto-de-ginecologia-in-rio-de-janeiro-in-the-mid-twentieth-century
#3
Vanessa Lana
Instituto de Ginecologia (Institute of Gynecology), in Rio de Janeiro, headed by Dr. Arnaldo de Moraes, was the first institution in Brazil to introduce and divulge medical techniques for the control of cervical cancer in the mid-1900s. It became a benchmark for actions geared towards the disease at the time, organizing a specific diagnostic procedure that set Brazilian medicine apart in the field, in which it remained a leader until the 1970s. The aim of this text is to discuss the organization and running of the institution from two perspectives: its role in enhancing the position of gynecology as a medical specialty, and its role in spreading a standard practice for the control of cervical cancer...
July 2016: História, Ciências, Saúde—Manguinhos
https://www.readbyqxmd.com/read/27430575/guiana-dolphins-sotalia-guianensis-and-dr-calux-for-screening-coastal-brazilian-environments-for-dioxins-and-related-compounds
#4
Paulo R Dorneles, José Lailson-Brito, Tatiana L Bisi, Camila Domit, Lupércio A Barbosa, Ana C O Meirelles, Vitor L Carvalho, Olaf Malm, Alexandre F Azevedo, François Brose, Krishna Das, Marie-Louise Scippo
Guiana dolphin is the top predator of highest toxicological concern in Brazil and many studies on levels of persistent, bioaccumulative, and toxicant (PBT) pollutants have been performed on the species. However, due to high costs of the analyses, only one investigation comprised the determination of dioxins and related compounds (DRCs) in Guiana dolphin tissues. The dioxin responsive-chemically activated luciferase gene expression (DR-CALUX(®)) cell bioassay was used in the present study for the analyses of hepatic samples from 28 male Guiana dolphins in order to screen estuarine environments for DRCs, comprising three regions (Northeastern, Southeastern, and Southern) and four states [Paraná (PR), Rio de Janeiro (RJ), Espírito Santo (ES), and Ceará (CE)] of Brazil...
October 2016: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/27355626/surveillance-of-hiv-transmitted-drug-resistance-in-latin-america-and-the-caribbean-a-systematic-review-and-meta-analysis
#5
Santiago Avila-Rios, Omar Sued, Soo-Yon Rhee, Robert W Shafer, Gustavo Reyes-Teran, Giovanni Ravasi
BACKGROUND: HIV transmitted drug resistance (TDR) remains at moderate level in Latin America and the Caribbean (LAC). However, different epidemiologic scenarios could influence national and sub-regional TDR levels and trends. METHODS AND FINDINGS: We performed a systematic review of currently available publications on TDR in antiretroviral treatment-naïve adults in LAC. Ninety-eight studies published between January 2000 and June 2015 were included according to critical appraisal criteria and classified by sub-region: Brazil (50), Mesoamerica (17), Southern Cone (16), Andean (8) and Caribbean (7)...
2016: PloS One
https://www.readbyqxmd.com/read/27350786/highlights-of-the-ecancer-sac-first-international-prostate-cancer-symposium-11-12-march-2016-buenos-aires-argentina
#6
Marcelo Blanco Villalba, Marina Bramajo, Mario Bruno
The ecancer/SAC First International Prostate Cancer Symposium, held in Buenos Aires, included national, regional, and international experts in the field of prostate cancer. More than 200 professionals from a variety of areas (clinical urologists, pathologists, oncologists, biologists, imaging specialists, radiation therapists, and generalist doctors, among others) attended, and they proposed multidisciplinary management of prostate pathology from the start in concordance with the ideas set forth by the organising committee...
2016: Ecancermedicalscience
https://www.readbyqxmd.com/read/27304097/zika-is-not-a-reason-for-missing-the-olympic-games-in-rio-de-janeiro-response-to-the-open-letter-of-dr-attaran-and-colleagues-to-dr-margaret-chan-director-general-who-on-the-zika-threat-to-the-olympic-and-paralympic-games
#7
Claudia Codeço, Daniel Villela, Marcelo F Gomes, Leonardo Bastos, Oswaldo Cruz, Claudio Struchiner, Luis Max Carvalho, Flavio Coelho
Attaran and colleagues in an open letter to WHO expressed their concern about the upcoming Olympic and Paralympic Games in Rio de Janeiro and the threat posed by the Zika epidemic (Attaran 2016). We agree that Zika virus is of great public health concern and much remains to be known about this disease. Care should be taken to reduce the risk of infection, especially to pregnant women. However, we argue that this is not sufficient reason for changing the original plans for the Games, in particular because of the time of the year when they will take place...
June 2016: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/26973470/p%C3%A3-o-del-r%C3%A3-o-ortega-a-pioneer-in-the-pathology-of-central-nervous-system-tumors
#8
REVIEW
Santiago Ramon Y Cajal Agüeras
The last 140 years have seen considerable advances in knowledge of central nervous system tumors. However, the main tumor types had already been described during the early years of the twentieth century. The studies of Dr. Pío del Río Hortega have been ones of the most exhaustive histology and cytology-based studies of nervous system tumors. Río Hortega's work was performed using silver staining methods, which require a high level of practical skill and were therefore difficult to standardize. His technical aptitude and interest in nervous system tumors played a key role in the establishment of his classification, which was based on cell lineage and embryonic development...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/26808823/identification-of-immunogenic-cytotoxic-t-lymphocyte-epitopes-containing-drug-resistance-mutations-in-antiretroviral-treatment-na%C3%A3-ve-hiv-infected-individuals
#9
Juan Blanco-Heredia, Aarón Lecanda, Humberto Valenzuela-Ponce, Christian Brander, Santiago Ávila-Ríos, Gustavo Reyes-Terán
BACKGROUND: Therapeutic HIV vaccines may prove helpful to intensify antiretroviral treatment (ART) efficacy and may be an integral part of future cure strategies. METHODS: We examined IFN-gamma ELISpot responses to a panel of 218 HIV clade B consensus-based HIV protease-reverse transcriptase peptides, designed to mimic previously described and predicted cytotoxic T lymphocyte epitopes overlapping drug resistance (DR) positions, that either included the consensus sequence or the DR variant sequence, in 49 ART-naïve HIV-infected individuals...
2016: PloS One
https://www.readbyqxmd.com/read/26748868/a-multifunctional-contrast-dye-for-morphological-research
#10
Qian Xia, Yuanbo Feng, Ting Yin, Yewei Liu, Sayuan Liang, Jianjun Liu, Linjun Tong, Gang Huang, Jie Yu, Yansheng Jiang, Uwe Himmelreich, Raymond Oyen, Yicheng Ni
OBJECTIVES: We sought to devise and test a multifunctional contrast dye agent for X-ray based digital radiography (DR) or computer tomography (CT), magnetic resonance imaging (MRI), and colored staining in ex vivo validation part of animal experiments. MATERIALS AND METHODS: The custom-formulated contrast dye namely red iodized oil (RIO) was prepared by solubilizing a lipophilic dye Oil Red O in iodized poppy seed oil (Lipiodol or LPD) followed by physicochemical characterizations...
February 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/26712652/-intrauterine-growth-and-biochemical-levels-in-cord-blood-samples-in-infants-less-than-31-weeks-gestation
#11
Patricia Mena Nannig, M Paz Cubillos Celis, Claudia Toro Jara, Carlos Zuñiga Vergara
INTRODUCTION: The use of greater amounts of protein and energy during the first week of life is associated with hypophosphataemia in extreme preterm babies. The lowest phosphorus levels are described in intrauterine growth restricted (IUGR) babies. OBJECTIVES: To describe biochemistry levels in cord blood plasma in extreme premature, adequate and small for gestational age babies (AGA/SGA) and their relationship with plasma calcium and phosphorus levels during the first week of life...
July 2016: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/26558396/hiv-drug-resistance-surveillance-in-honduras-after-a-decade-of-widespread-antiretroviral-therapy
#12
Santiago Avila-Ríos, Claudia García-Morales, Daniela Tapia-Trejo, Rita I Meza, Sandra M Nuñez, Leda Parham, Norma A Flores, Diana Valladares, Luisa M Pineda, Dixiana Flores, Roxana Motiño, Víctor Umanzor, Candy Carbajal, Wendy Murillo, Ivette Lorenzana, Elsa Y Palou, Gustavo Reyes-Terán
INTRODUCTION: We assessed HIV drug resistance (DR) in individuals failing ART (acquired DR, ADR) and in ART-naïve individuals (pre-ART DR, PDR) in Honduras, after 10 years of widespread availability of ART. METHODS: 365 HIV-infected, ART-naïve, and 381 ART-experienced Honduran individuals were enrolled in 5 reference centres in Tegucigalpa, San Pedro Sula, La Ceiba, and Choluteca between April 2013 and April 2015. Plasma HIV protease-RT sequences were obtained...
2015: PloS One
https://www.readbyqxmd.com/read/26436791/-beginning-of-the-microbiology-education-in-chile-formation-centers
#13
Carlos Osorio
The first Chair of Microbiology in Chile was created in the School of Medicine of the Cañadilla at the University of Chile in 1892. Dr. Alejandro del Río Soto Aguilar was its first Professor. For almost three decades it was the only educational center for microbiologists in Chile. Among them were the first Professors of the new School of Medicine of the Catholic University of Chile and of the University of Concepción.
August 2015: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/26240697/importance-of-telemedicine-in-diabetes-care-relationships-between-family-physicians-and-ophthalmologists
#14
Pedro Romero-Aroca, Ramon Sagarra-Alamo, Alicia Pareja-Rios, Maribel López
Diabetic retinopathy (DR) is the worldwide leading cause of legal blindness. In 2010, 1.9% of diabetes mellitus (DM) patients were legally blind and 10.2% had visual impairment. The control of DM parameters (glycemia, arterial tension and lipids) is the gold standard for preventing DR complications, although, unfortunately, DR still appeared in a 25% to 35% of patients. The stages of severe vision threading DR, include proliferative DR (6.96%) and diabetic macular edema (6.81%). This review aims to update our knowledge on DR screening using telemedicine, the different techniques, the problems, and the inclusion of different professionals such as family physicians in care programs...
July 25, 2015: World Journal of Diabetes
https://www.readbyqxmd.com/read/26190611/combining-enhanced-biomass-density-with-reduced-lignin-level-for-improved-forage-quality
#15
Lina Gallego-Giraldo, Gail Shadle, Hui Shen, Jaime Barros-Rios, Sandra Fresquet Corrales, Huanzhong Wang, Richard A Dixon
To generate a forage crop with increased biomass density that retains forage quality, we have genetically transformed lines of alfalfa (Medicago sativa L.) expressing antisense constructs targeting two different lignin pathway biosynthetic genes with a construct for down-regulation of a WRKY family transcription factor that acts as a repressor of secondary cell wall formation in pith tissues. Plants with low-level expression of the WRKY dominant repressor construct produced lignified cell walls in pith tissues and exhibited enhanced biomass and biomass density, with an increase in total sugars in the cell wall fraction; however, lines with high expression of the WRKY dominant repressor construct exhibited a very different phenotype, with loss of interfascicular fibres associated with repression of the NST1 transcription factor...
March 2016: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/26075231/disparities-in-prevalence-of-smoking-and-smoking-cessation-during-pregnancy-a-population-based-study
#16
MULTICENTER STUDY
Josiane L Dias-Damé, Juraci A Cesar
OBJECTIVE: To examine time trends in prevalence of smoking and smoking cessation during pregnancy by family income, maternal level of education, skin color, and age. METHODS: We conducted three population-based surveys in 2007, 2010, and 2013 with newly delivered mothers living in the municipality of Rio Grande, Southern Brazil. Data were collected using questionnaires administered after delivery in all (two) maternity units in the city, at Dr. Miguel Riet Corrêa Júnior Hospital and at Santa Casa de Misericórdia...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26061372/temporal-distribution-of-tuberculosis-in-the-state-of-amazonas-brazil
#17
REVIEW
Marlucia da Silva Garrido, Samira Bührer-Sékula, Alexandra Brito de Souza, Rajendranath Ramasawmy, Patrícia de Lima Quincó, Rossicleia Lins Monte, Lucilaide Oliveira Santos, Tomás Maria Perez-Porcuna, Flor Ernestina Martinez-Espínosa, Valéria Saraceni, Marcelo Cordeiro-Santos
Tuberculosis (TB) is one of the infectious diseases that contributes most to the morbidity and mortality of millions of people worldwide. Brazil is one of 22 countries that accounts for 80% of the tuberculosis global burden. The highest incidence rates in Brazil occur in the States of Amazonas and Rio de Janeiro. The aim of this study was to describe the temporal distribution of TB in the State of Amazonas. Between 2001 and 2011, 28,198 cases of tuberculosis were reported in Amazonas, distributed among 62 municipalities, with the capital Manaus reporting the highest (68...
2015: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/25955940/clinical-management-of-borderline-ovarian-tumors-in-dr-sotero-del-rio-hospital-igcs-0068-ovarian-cancer
#18
O Puga, M V Perez, M Farias, N Saez, M I Barriga, K Garcia, M Saavedra, M Fernandez, T Rodriguez
No abstract text is available yet for this article.
May 2015: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/25739030/quantitative-computed-tomographic-descriptors-associate-tumor-shape-complexity-and-intratumor-heterogeneity-with-prognosis-in-lung-adenocarcinoma
#19
Olya Grove, Anders E Berglund, Matthew B Schabath, Hugo J W L Aerts, Andre Dekker, Hua Wang, Emmanuel Rios Velazquez, Philippe Lambin, Yuhua Gu, Yoganand Balagurunathan, Edward Eikman, Robert A Gatenby, Steven Eschrich, Robert J Gillies
Two CT features were developed to quantitatively describe lung adenocarcinomas by scoring tumor shape complexity (feature 1: convexity) and intratumor density variation (feature 2: entropy ratio) in routinely obtained diagnostic CT scans. The developed quantitative features were analyzed in two independent cohorts (cohort 1: n = 61; cohort 2: n = 47) of patients diagnosed with primary lung adenocarcinoma, retrospectively curated to include imaging and clinical data. Preoperative chest CTs were segmented semi-automatically...
2015: PloS One
https://www.readbyqxmd.com/read/25679930/-epidemiology-of-febrile-neutropenia-in-adult-patients-with-acute-leukemia-and-lymphoma-cohort-study-of-public-and-private-hospital-of-santiago-chile
#20
Ricardo Rabagliati, Pablo Bertín, Inés Cerón, Hernán Rojas, Isabel Domínguez, Álvaro Vera, Leonardo Sir, Jimena Flores, Paulina Fernández, Marco Pérez, Rolando De La Cruz
INTRODUCTION: Febrile neutropenia (FN) is a common complication of patients undergoing chemotherapy (QMT). Clinical presentation is varied, from mild fever to severe sepsis with invasive bacterial infection (IBI) or invasive fungal infection (IFI), with great impact on prognosis and patient mortality. PATIENTS AND METHODS: Prospective cohort study of FN episodes in adult patients with acute leukemia (AL) or lymphoma (L), diagnosed and treated at the Hospital Clínico Universidad Católica and Hospital Dr...
December 2014: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
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