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https://www.readbyqxmd.com/read/28727368/medical-ozone-therapy-reduces-oxidative-stress-and-testicular-damage-in-an-experimental-model-of-testicular-torsion-in-rats
#1
Mustafa Tusat, Ahmet Mentese, Selim Demir, Ahmet Alver, Mustafa Imamoglu
OBJECTIVE: Testicular torsion (TT) refers to rotation of the testis and twisting of the spermatic cord. TT results in ischemia-reperfusion (I/R) injury involving increased oxidative stress, inflammation and apoptosis, and can even lead to infertility. The aim of this study was to investigate the effect of ozone therapy on testicular damage due to I/R injury in an experimental torsion model. MATERIALS AND METHODS: 24 male Sprague-Dawley rats were divided into 3 groups; sham-operated, torsion/detorsion (T/D), and T/D+ozone...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28726405/fluorescence-enhancement-of-unconstrained-gfp-chromophore-analogues-based-on-the-push-pull-substituent-effect
#2
Meng-Shiue Tsai, Chun-Lin Ou, Chi-Jui Tsai, Yen-Chin Huang, Yuan-Chung Cheng, Shih-Sheng Sun, Jye-Shane Yang
Unlike the high fluorescence quantum yield of the naturally occurring green fluorescence protein (GFP, Φf ∼ 0.8), the GFP chromophore, a benzylidenedimethylimidazolinone (BDI) dye, is nearly nonfluorescent (Φf < 0.001) in common solutions at room temperature. While many efforts have been devoted into the BDI chromophore engineering for fluorescence recovery, limited success has been achieved for structurally unconstrained GFP chromophore analogues (uGFPc). Herein we report a rational design of uGFPc toward an unprecedentedly high fluorescence quantum efficiency of 0...
July 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28725616/chronic-orchialgia-epidemiology-diagnosis-and-evaluation
#3
REVIEW
John T Sigalos, Alexander W Pastuszak
Chronic orchialgia is a vexing condition defined as chronic or intermittent scrotal pain lasting at least three months that significantly interferes with daily activities. There are currently no guidelines regarding the diagnosis and management of this condition despite it being the cause of 2.5-4.8% of urologic clinic visits. Men often present with chronic orchialgia in their mid to late 30s, although the condition can present at any age. A broad differential diagnosis of chronic orchialgia includes epididymitis, testicular torsion, tumors, obstruction, varicocele, epididymal cysts, hydrocele, iatrogenic injury following vasectomy or hernia repair, and referred pain from a variety of sources including mid-ureteral stone, indirect inguinal hernia, aortic or common iliac artery aneurysms, lower back disorders, interstitial cystitis, and nerve entrapment due to perineural fibrosis; approximately 25-50% of chronic orchialgia is idiopathic in nature...
May 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28725046/the-location-of-the-deepest-point-of-the-eyeball-determines-the-optic-disc-configuration
#4
Yong Chan Kim, Younhea Jung, Hae-Young Lopilly Park, Chan Kee Park
Tilted and rotated appearances are hallmarks of the myopic optic disc. As the eyeball grows axially, the posterior pole elongates not only globally but in a localized manner as well. In this process, the optic disc is pulled towards the deepest point of the elongated eyeball, which might result in a change in optic disc configuration. Thus, we hypothesized that analyzing the variation of posterior pole contour can play a major role in understanding optic disc configuration in myopic subjects. By analyzing consecutive images of swept source OCT coronal sections at the posterior pole, the deepest interface between Bruch's membrane and the choroid could be identified as the deepest point of the eyeball (DPE)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723609/failure-analysis-of-eleven-gates-glidden-drills-that-fractured-intraorally-during-post-space-preparation-a-retrieval-analysis-study
#5
Youssef S Al Jabbari, Raymond Fournelle, Sara M Al Taweel, Spiros Zinelis
The purpose of this study was to determine the failure mechanism of clinically failed Gates Glidden (GG) drills. Eleven retrieved GG drills (sizes #1 to #3) which fractured during root canal preparation were collected and the fracture location was recorded based on macroscopic observation. All fracture surfaces were investigated by a SEM. Then the fractured parts were embedded in acrylic resin and after metallographic preparation, the microstructure and elemental composition was evaluated by SEM and EDS. The Vickers hardness (HV) of all specimens was also determined...
July 19, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28722730/tunable-in-plane-torsional-strength-of-surface-functionalized-two-dimensional-nanomaterials
#6
Qianling Lin, Yinfeng Li, Haimin Yao
In this paper, the in-plane torsional properties of two dimensional nanomaterials are revealed to be tunable by surface functionalization using molecular dynamics simulations. The torsional strengths of both graphene and graphyne under circular shearing are found to first decrease and then increase anomalously with the increase of the hydrogenation ratio. The minimum strength of such U-shaped strength evolution appears at different hydrogenation ratios H for graphene (H = 50%) and graphyne (H = 70%), demonstrating a correlation between hydrogenation and the unit lattices of 2D nanomaterials...
July 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28720913/should-torsion-balance-technique-continue-to-be-taught-to-pharmacy-students
#7
Rhonda Bilger, Rasma Chereson, Noha Nabil Salama
Objective. To determine the types of balances used in compounding pharmacies: torsion or digital. Methods. A survey was mailed to the pharmacist-in-charge at 698 pharmacies, representing 47% of the pharmacies in Missouri as of July 2013. The pharmacies were randomly selected and stratified by region into eight regions to ensure a representative sample. Information was gathered regarding the type and use of balances and pharmacists' perspectives on the need to teach torsion balance technique to pharmacy students...
June 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28719995/biomechanics-of-the-proximal-radius-following-drilling-of-the-bicipital-tuberosity-to-mimic-cortical-button-distal-biceps-repair-technique
#8
Nikhil R Oak, John R Lien, Alexander Brunfeldt, Jeffrey N Lawton
BACKGROUND: A fracture through the proximal radius is a theoretical concern after cortical button distal biceps fixation in an active patient. The permanent, nonossified cortical defect and medullary tunnel is at risk during a fall eliciting rotational and compressive forces. We hypothesized that during simulated torsion and compression, in comparison with unaltered specimens, the cortical button distal biceps repair model would have decreased torsional and compressive strength and would fracture in the vicinity of the bicipital tuberosity bone tunnel...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28717555/adaptive-nonparametric-kinematic-modeling-of-concentric-tube-robots
#9
Georgios Fagogenis, Christos Bergeles, Pierre E Dupont
Concentric tube robots comprise telescopic precurved elastic tubes. The robot's tip and shape are controlled via relative tube motions, i.e. tube rotations and translations. Non-linear interactions between the tubes, e.g. friction and torsion, as well as uncertainty in the physical properties of the tubes themselves, e.g. the Young's modulus, curvature, or stiffness, hinder accurate kinematic modelling. In this paper, we present a machine-learning-based methodology for kinematic modelling of concentric tube robots and in situ model adaptation...
October 2016: Proceedings of the ... IEEE/RSJ International Conference on Intelligent Robots and Systems
https://www.readbyqxmd.com/read/28716441/unraveling-the-meaning-of-chemical-shifts-in-protein-nmr
#10
REVIEW
Mark V Berjanskii, David S Wishart
Chemical shifts are among the most informative parameters in protein NMR. They provide wealth of information about protein secondary and tertiary structure, protein flexibility, and protein-ligand binding. In this report, we review the progress in interpreting and utilizing protein chemical shifts that has occurred over the past 25years, with a particular focus on the large body of work arising from our group and other Canadian NMR laboratories. More specifically, this review focuses on describing, assessing, and providing some historical context for various chemical shift-based methods to: (1) determine protein secondary and super-secondary structure; (2) derive protein torsion angles; (3) assess protein flexibility; (4) predict residue accessible surface area; (5) refine 3D protein structures; (6) determine 3D protein structures and (7) characterize intrinsically disordered proteins...
July 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28715186/improving-the-efficiency-of-configurational-bias-monte-carlo-extension-of-the-jacobian-gaussian-scheme-to-interior-sections-of-cyclic-and-polymeric-molecules
#11
Aliasghar Sepehri, Troy D Loeffler, Bin Chen
The Jacobian-Gaussian method, which has been recently developed for generating bending angle trials, is extended to the conformational sampling of inner segments of a long chain or a cyclic molecule where regular configurational-bias Monte Carlo was found to be very inefficient or simply incapable (i.e., for the cyclic case). For these molecules, a new conformational move would be required where one interior section is relocated while the rest of the molecule, before and after this section, is fixed. Techniques have been developed to extend the regular configurational-bias Monte Carlo to such a fixed-endpoints case by introducing a biasing probability function...
July 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28715184/theoretical-investigation-of-c-h-vibrational-spectroscopy-i-modeling-of-methyl-and-methylene-groups-of-ethanol-with-different-conformers
#12
Lin Wang, Tatsuya Ishiyama, Akihiro Morita
A flexible and polarizable molecular model of ethanol is developed to extend our investigation of thermodynamic, structural and vibrational properties of liquid and interface. Molecular dynamics (MD) simulation with the present model confirmed that this model well reproduces a number of properties of liquid ethanol, including density, heat of vaporization, surface tension, molecular dipole moment, and trans/gauche ratio. In particular, the present model can describe vibrational IR, Raman and sum frequency generation (SFG) spectra of ethanol and partially deuterated analogues with reliable accuracy...
July 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28715039/erratum-to-computed-tomographic-evaluation-of-femoral-and-tibial-conformation-in-english-staffordshire-bull-terriers-with-and-without-congenital-medial-patellar-luxation
#13
Mark Newman, Katja Voss
OBJECTIVE: To compare hindlimb conformation of English Staffordshire Bull Terriers with and without medial patellar luxation using computed tomography. METHODS: Hindlimb computed tomography (CT) was performed on six English Staffordshire Bull Terriers with grade II or III medial patellar luxation, and six without medial patellar luxation. Inclination angle, femoral condyle trochanteric angle, anteversion angle (AA), distal anteversion angle (DAA), proximal anteversion angle (PAA), femoral varus angle (FVA), tibial valgus angle (TVA), and tibial torsion angle (TTA) were measured...
July 10, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28714632/-diagnosis-and-management-of-testicular-torsion-in-children
#14
Vanina Estremadoyro, Blaise Julien Meyrat, Jacques Birraux, Isabelle Vidal, Oliver Sanchez
Testicular torsion is a true urologic emergency with a bimodal age presentation : the perinatal testicular torsion presenting with a hard, tender or non-tender scrotal mass usually with underlying dark discoloration of the skin and the peripubertal testicular torsion presenting with severe acute testicular pain, vomiting and frequently pain irradiation in the inguinal area, a high riding-horizontally positioned testis and absence of the cremasteric reflex. Obtaining a US Doppler must not add unnecessary delay to the urgent surgical treatment which entails detorsion and bilateral orchidopexy...
February 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28713055/anterior-and-nasal-transposition-of-inferior-oblique-muscle-in-cases-of-superior-oblique-palsy
#15
Rohit Saxena, Medha Sharma, Digvijay Singh, Pradeep Sharma
PURPOSE: To report long-term outcome of inferior oblique anterior and nasal transposition in superior oblique palsy. METHODS: The medical records of patients with superior oblique palsy who underwent inferior oblique anterior nasal transposition were reviewed retrospectively. A comprehensive ophthalmic evaluation, including prism bar cover test and measurement of torsion, was performed for all cases. One-year postoperative results were evaluated for alignment in primary gaze, contralateral gaze, and upgaze; reduction in inferior oblique overaction and changes in fundus torsion to assess long-term outcome of the procedure...
July 13, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28713006/ultrasonographic-findings-in-the-epididymis-of-pediatric-patients-with-testicular-torsion
#16
C E Afsarlar, R Elizondo, E Yilmaz, E Cakmakci, D J Ballow, E Demir, G Guney, C J Koh
INTRODUCTION: Although grayscale ultrasound and color Doppler ultrasound characteristics of the torsed testis are well established in the literature, less is known about its anatomic partner: the epididymis. OBJECTIVE: The purpose of this study was to describe the ultrasound characteristics of the epididymis in pediatric patients with testicular torsion, and to describe their potential role as prognostic criteria for testicular salvage outcomes. STUDY DESIGN: During a retrospective review of 217 pediatric patients with acute testicular torsion during 2009-2016, morphological features of the epididymis from scrotal ultrasounds (size, parenchymal characteristics, and vascular flow of both epididymis heads), as well as patient demographics, time duration, surgical outcomes, histopathology results, and follow-up periods were analyzed...
June 19, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28711059/the-effect-of-surface-adsorption-on-tertiary-structure-formation-in-helical-polymers
#17
Matthew J Williams, Michael Bachmann
The formation of tertiary structures made up of helical polymer segments is influenced by the introduction of an attractive substrate onto which the polymer can adsorb. We perform replica-exchange Monte Carlo simulations to study the formation of helical structures in the vicinity of an attractive generic substrate by means of a coarse-grained hybrid model and compare the structural phase space for both adsorbed and free helical polymers. We introduce suitable structural order parameters to understand the features of distinct structural phases...
July 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28709252/magnetorheological-response-of-highly-filled-magnetoactive-elastomers-from-perspective-of-mechanical-energy-density-fractal-aggregates-above-the-nanometer-scale
#18
Vladislav V Sorokin, Inna A Belyaeva, Mikhail Shamonin, Elena Yu Kramarenko
The dynamic shear modulus of magnetoactive elastomers containing 70 and 80 mass % of carbonyl iron microparticles is measured as a function of strain amplitude via dynamic torsion oscillations in various magnetic fields. The results are presented in terms of the mechanical energy density and considered in the framework of the conventional Kraus model. The form exponent of the Kraus model is further related to a physical model of Huber et al. [Huber et al., J. Phys.: Condens. Matter 8, 409 (1996)10.1088/0953-8984/8/29/003] that uses a realistic representation for the cluster network possessing fractal structure...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28709244/chiral-edge-fluctuations-of-colloidal-membranes
#19
Leroy L Jia, Mark J Zakhary, Zvonimir Dogic, Robert A Pelcovits, Thomas R Powers
We study edge fluctuations of a flat colloidal membrane comprised of a monolayer of aligned filamentous viruses. Experiments reveal that a peak in the spectrum of the in-plane edge fluctuations arises for sufficiently strong virus chirality. Accounting for internal liquid crystalline degrees of freedom by the length, curvature, and geodesic torsion of the edge, we calculate the spectrum of the edge fluctuations. The theory quantitatively describes the experimental data, demonstrating that chirality couples in-plane and out-of-plane edge fluctuations to produce the peak...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28709049/idiopathic-spontaneous-pulmonary-torsion-of-the-lingula-a-case-report
#20
Masatoshi Kanayama, Toshihiro Osaki, Natsumasa Nishizawa, Makoto Nakagawa, Tomoko So, Mantaro Kodate
INTRODUCTION: Spontaneous pulmonary torsion is an extremely rare event and is known to occur as a complication of thoracic surgery and traumatic injuries. PRESENTATION OF CASE: An 18-year-old man presented to our hospital with pain in the left back region. Clinical examination, computed tomography and bronchoscopy are crucial for diagnosis of pulmonary torsion. During thoracotomy, the lingula segment was observed to be bent on the head side and turned 180° counterclockwise; subsequently, lingulectomy was performed...
June 29, 2017: International Journal of Surgery Case Reports
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