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Yoshimitsu Ohgiya, Noritaka Seino, Shingo Miyamoto, Nobuyuki Takeyama, Kumi Hatano, Jiro Munechika, Kumiko Ishizuka, Masanori Hirose, Nobuyuki Ohike, Toshi Hashimoto, Akihiko Sekizawa, Takehiko Gokan
PURPOSE: To evaluate the usefulness of computed tomographic (CT) features for identifying acute torsion of uterine subserosal leiomyoma (USL). SUBJECTS AND METHODS: We analyzed contrast-enhanced CT examinations of 7 USLs with torsion and 44 USLs without torsion. Two radiologists evaluated the CT features, which consisted of poor contrast enhancement inside the USL, thin rim enhancement around the USL, calcification within the USL, a beak sign between the uterus and USL, fan-shaped poor contrast enhancement in the uterus area adjacent to the USL (dark fan sign), and ascites...
December 9, 2017: Japanese Journal of Radiology
Murilo Priori Alcalde, Marco Antonio Hungaro Duarte, Clovis Monteiro Bramante, Bruno Carvalho de Vasconselos, Mario Tanomaru-Filho, Juliane Maria Guerreiro-Tanomaru, Jader Carvalho Pinto, Marcus Vinicius Reis Só, Rodrigo Ricci Vivan
OBJECTIVES: The aim of this study was to evaluate the cyclic and torsional fatigue resistance of the reciprocating single-file systems Reciproc Blue 25.08 (VDW GmbH, Munich, Germany), Prodesign R 25.06 (Easy Dental Equipment, Belo Horizonte, Brazil), and WaveOne Gold 25.07 (Dentsply/Tulsa Dental Specialties, Tulsa, OK, USA). MATERIALS AND METHODS: Sixty reciprocating instruments of the systems Reciproc Blue R25 (RB #25 .08 taper), Prodesign R (PDR #25 .06 taper), and WaveOne Gold (WOG #25 ...
December 9, 2017: Clinical Oral Investigations
Nicholas R Pannunzio, Michael R Lieber
DNA double-strand breaks (DSBs) occurring within fragile zones of less than 200 base pairs account for the formation of the most common human chromosomal translocations in lymphoid malignancies, yet the mechanism of how breaks occur remains unknown. Here, we have transferred human fragile zones into S. cerevisiae in the context of a genetic assay to understand the mechanism leading to DSBs at these sites. Our findings indicate that a combination of factors is required to sensitize these regions. Foremost, DNA strand separation by transcription or increased torsional stress can expose these DNA regions to damage from either the expression of human AID or increased oxidative stress...
December 7, 2017: Molecular Cell
Sumitabha Brahmachari, Kathryn H Gunn, Rebecca D Giuntoli, Alfonso Mondragón, John F Marko
We study the statistical-mechanical properties of intertwined double-helical DNAs (DNA braids). In magnetic tweezers experiments, we find that torsionally stressed stretched braids supercoil via an abrupt buckling transition, which is associated with the nucleation of a braid end loop, and that the buckled braid is characterized by a proliferation of multiple domains. Differences between the mechanics of DNA braids and supercoiled single DNAs can be understood as an effect of the increased bulkiness in the structure of the former...
November 3, 2017: Physical Review Letters
L Lorenzo, E Martínez-Cuenca, E Broseta
Bilateral testicular torsion is a very uncommon emergency, with a challenging differential diagnosis. We describe the case of a 15-year-old patient with a left testicular torsion of 48 hours of duration and a sudden onset of right scrotum pain during his stay at the emergency area. Bilateral testicular torsion was diagnosed after repeat physical examination and doppler ultrasound, which had been normal for right testis in a first evaluation. Surgical exploration was performed with orchiectomy in left testis and fixation in right testis...
December 11, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Dominic J Lee
At present, there have been suggested two types of physical mechanism that may facilitate preferential pairing between DNA molecules, with identical or similar base pair texts, without separation of base pairs. One solely relies on base pair specific patterns of helix distortion being the same on the two molecules, discussed extensively in the past. The other mechanism proposes that there are preferential interactions between base pairs of the same composition. We introduce a model, built on this second mechanism, where both thermal stretching and twisting fluctuations are included, as well as the base pair specific helix distortions...
December 8, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Pia Bader, Christoph Hugemann, Detlef Frohneberg
Acute scrotal pain in childhood is an emergency.Sudden scrotal pain may be caused by a variety of diseases. Therefore, it is important to carefully consider the specific medical history and possible differential diagnoses in each case for fast and decisive action (e. g. in case of testicular torsion). As minors lack the capacity for consent, it is absolutely necessary to obtain consent from their legal guardian. However, obtaining consent in the available time frame can cause organisational challenges in an acute emergency, which may lead to situations in the daily routine where a therapeutic decision needs to be taken (including surgery) without legal security based on consent by the guardian...
December 2017: Aktuelle Urologie
Peter R Franke, Gary E Douberly
Isoprene (C5H8) is an abundant, reactive tropospheric hydrocarbon, derived from biogenic emissions. A detailed understanding of the spectroscopy of isoprene is therefore desirable. Isoprene monomer is isolated in helium droplets and its infrared spectrum is measured in the CH stretching region. Anharmonic frequencies are predicted by VPT2+K simulations employing CCSD(T) force fields with quadratic (cubic and quartic) force constants computed using the ANO1 (ANO0) basis set. The vast majority of the spectral features can be assigned to trans-isoprene on the basis of these computations...
December 7, 2017: Journal of Physical Chemistry. A
R Enzinger, Chr Neubauer, J Kotzurek, W Sprengel, R Würschum
A kinetic model for the diffusion-controlled annealing of excess vacancies under the experimentally relevant, non-isothermal condition of time-linear heating is presented and applied to dilatometry. The evolution of the vacancy concentration with time is quantitatively analyzed, considering as ideal sinks either dislocations or grain boundaries of spherical- or cylindrical-shaped crystallites. The validity of the model is tested using dilatometry data that were obtained for ultrafine-grained Ni prepared by high-pressure torsion...
2018: Journal of Materials Science
Li Li, Peipei Shi, Li Hua, Jianing An, Yujiao Gong, Ruyi Chen, Chenyang Yu, Weiwei Hua, Fei Xiu, Jinyuan Zhou, Guangfa Gao, Zhong Jin, Gengzhi Sun, Wei Huang
A wearable and shape-memory strain sensor with a coaxial configuration is designed, comprising a thermoplastic polyurethane fiber as the core support, well-aligned and interconnected carbon nanotubes (CNTs) as conductive filaments, and polypyrrole (PPy) coating as the cladding layer. In this design, the stress relaxation between CNTs is well confined by the outer PPy cladding layer, which endows the fibriform sensor with good reliability and repeatability. The microcracks generated when the coaxial fiber is under strain guarantee the superior sensitivity of this fibriform sensor with a gauge factor of 12 at 0...
December 6, 2017: Nanoscale
Kaspars Traskovskis, Arturs Bundulis, Igors Mihailovs
One of the strongest known electron-accepting fragments used in the synthesis of organic dyes for applications in nonlinear optics (NLO) is 1,3-bis(dicyanomethylidene)indane (BDMI). By studying a benzylidene-type push-pull chromophore bearing a 5-carboxy-BDMI electron-acceptor and 4-(dimethylamino)aniline donor fragment, we demonstrate that this class of compounds can show unusual response to the polarity of the surrounding medium. The combined results of UV-Vis absorption spectrometry, NMR experiments and computational modeling indicate that the studied compound undergoes a geometrical transformation that involves an increase in the torsion angle ω between the aniline and indane ring systems with the rise of the polarity of the surrounding medium...
December 6, 2017: Physical Chemistry Chemical Physics: PCCP
Louis F Dell'Osso, Suber S Huang
PURPOSE: To report and discuss a focal oscillopsia in a small area of the visual field produced by, and after the removal of, an epiretinal membrane (ERM) in an individual with infantile nystagmus syndrome (INS) since birth with no associated afferent visual deficits. STUDY DESIGN: A retrospective case report. METHODS: A chart review, including clinical and electrophysiological data. A 74 y/o man with INS and an epiretinal membrane was studied...
December 5, 2017: Japanese Journal of Ophthalmology
Elles J Dijkema, Martijn G Slieker, Johannes M P J Breur, Tim Leiner, Heynric B Grotenhuis
Arterial vasculopathy and residual aortic obstruction can lead to left ventricular (LV) dysfunction in patients with coarctation of the aorta (CoA) related to adverse ventriculo-arterial coupling. This study aimed to investigate potential differences in LV myocardial deformation indices between repaired CoA patients and healthy controls. Twenty-two CoA patients (age 30 ± 10.6 years) after surgical repair (n = 12) or balloon angioplasty (BA) (n = 10) without residual stenosis, between 3 months and 16 years of age with > 10 years follow-up were compared to 22 healthy age- and gender-matched controls (age 30 ± 3...
December 5, 2017: Pediatric Cardiology
Ainhoa Mariezcurrena, Frank Uhlmann
DNA replication of circular genomes generates physically interlinked or catenated sister DNAs. These are resolved through transient DNA fracture by type II topoisomerases to permit chromosome segregation during cell division. Topoisomerase II is similarly required for linear chromosome segregation, suggesting that linear chromosomes also remain intertwined following DNA replication. Indeed, chromosome resolution defects are a frequent cause of chromosome segregation failure and consequent aneuploidies. When and where intertwines arise and persist along linear chromosomes are not known, owing to the difficulty of demonstrating intertwining of linear DNAs...
December 5, 2017: Genes & Development
Nataliya R Rovnyagina, Nikolai N Sluchanko, Tatiana N Tikhonova, Victor V Fadeev, Artur Yu Litskevich, Alexander A Maskevich, Evgeny A Shirshin
Amyloid fibrils formation is the well-known hallmark of various neurodegenerative diseases. Thioflavin T (ThT)-based fluorescence assays are widely used to detect and characterize fibrils, however, if performed in bioliquids, the analysis can be biased due to the presence of other, especially abundant, proteins. Particularly, it is known that albumin may bind ThT, although the binding mechanism remains debatable. Here the role of low-order albumin oligomers in ThT binding is investigated using time-resolved fluorometry and size-exclusion chromatography...
December 2, 2017: International Journal of Biological Macromolecules
Sandesh Vithal Parab, Pramod Govindrao Salve, Aruna Dahiphale, Rupesh Thakare, Amit Aiwale
Meckel's Diverticulum (MD) is the most common congenital anomaly of gastrointestinal tract, occurring in 2% of the population. It is a true diverticulum and histologically all four intestinal layers are present within MD. There are various complications related to a Meckel's diverticulum, including haemorrhage, intestinal obstruction, inflammation and perforation. Axial torsion followed by gangrene of MD is the rarest of the complications that have been reported. The exact mechanism for torsion is unclear. Preoperative diagnosis of torsion of MD is difficult and often confused with appendicitis as pain is usually localized to right lower quadrant...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
Lazaros Vlachopoulos, Fabio Carrillo, Christian Gerber, Gábor Székely, Philipp Fürnstahl
BACKGROUND: With current 3-dimensional (3D) computer-based methods for the assessment of deformities, a surface registration method is applied to superimpose a computer model of the pathological bone onto a mirrored computer model of the contralateral side. However, because of bilateral differences, especially in humeral torsion, such template-based approaches may introduce bias in the assessment of a distal humeral deformity. We hypothesized that a novel registration approach might prove superior to the current approach in reducing such bias, thus yielding improved accuracy of 3D assessment of distal humeral deformities...
December 6, 2017: Journal of Bone and Joint Surgery. American Volume
Mohammad Farhan Khazali, Joern K Pomper, Peter Thier
Blinks do not only protect the eye, but they do also correct for torsional eye position deviations by blink-associated resetting eye movements (BARMs). Although BARMs are functionally distinct from other eye movements in the torsional dimension, it has remained open if BARMs observed in the horizontal and vertical dimensions (fixational BARMs) are not simply microsaccades coinciding with blinks. We show here that fixational BARMs are functionally distinct and complementary to microsaccades in the following way: First, they compensate for large fixational error more efficiently than microsaccades, secondly, their probability to be executed in eccentric eye positions is higher, and thirdly, they reset the eyes into a position zone that is broader as compared to microsaccades...
December 4, 2017: Scientific Reports
Todd Yecies, Jathin Bandari, Francis Schneck, Glenn Cannon
OBJECTIVES: To identify the rate at which testicular torsion occurs in a lateral direction and identify any predictors of direction of testicular rotation and orchiectomy METHODS: We performed a retrospective review of 104 cases of emergent scrotal exploration performed for testicular torsion by 3 pediatric urologists from 2003-2017. Patients with neonatal torsion, negative scrotal exploration, or exploration for presumed intermittent testicular torsion were excluded. Univariable logistic regression was performed to assess if any factors predicted direction of testicular rotation...
December 1, 2017: Urology
Rohit Agarwal, Medha Sharma, Rohit Saxena, Pradeep Sharma
PURPOSE: To evaluate surgical outcome of superior rectus transposition (SRT) in esotropic Duane syndrome (DS) and abducens nerve palsy. METHODS: Retrospective medical record analysis of all patients with esotropic DS and abducens nerve palsy treated with SRT at our center with minimum follow-up of 6 months. Primary outcome measures were esotropia in primary position and abduction limitation. Secondary outcome measures included head turn, stereopsis, and cyclovertical deviations...
November 30, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
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