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https://www.readbyqxmd.com/read/29779014/current-insights-on-use-of-growth-factors-as-therapy-for-intervertebral-disc-degeneration
#1
Justin C Kennon, Mohamed E Awad, Norman Chutkan, John DeVine, Sadanand Fulzele
Chronic low back pain is a critical health problem and a leading cause of disability in aging populations. A major cause of low back pain is considered to be the degeneration of the intervertebral disc (IVD). Recent advances in therapeutics, particularly cell and tissue engineering, offer potential methods for inhibiting or reversing IVD degeneration, which have previously been impossible. The use of growth factors is under serious consideration as a potential therapy to enhance IVD tissue regeneration. We reviewed the role of chosen prototypical growth factors and growth factor combinations that have the capacity to improve IVD restoration...
May 19, 2018: Biomolecular Concepts
https://www.readbyqxmd.com/read/29775839/veterinary-applications-of-pulsed-electromagnetic-field-therapy
#2
REVIEW
James S Gaynor, Sean Hagberg, Blake T Gurfein
Pulsed electromagnetic field (PEMF) therapy can non-invasively treat a variety of pathologies by delivering electric and magnetic fields to tissues via inductive coils. The electromagnetic fields generated by these devices have been found to affect a variety of biological processes and basic science understanding of the underlying mechanisms of action of PEMF treatment has accelerated in the last 10 years. Accumulating clinical evidence supports the use of PEMF therapy in both animals and humans for specific clinical indications including bone healing, wound healing, osteoarthritis and inflammation, and treatment of post-operative pain and edema...
May 7, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29770324/one-health-integration-a-proposed-framework-for-a-study-on-veterinarians-and-zoonotic-disease-management-in-ghana
#3
Sophie Françoise Valeix
In parallel with the recent world-wide promotion of One Health (OH) as a policy concept, a growing body of social science studies has raised questions about how successful OH policies and programs have been in managing some global health issues, such as zoonotic diseases. This paper briefly reviews this literature to clarify its critical perspective. Much of the literature on OH also is focused on health management at an international level and has paid less attention to implementation programs and policies for OH at the national and local levels, especially in low-and-middle-income countries (LMICs)...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29769009/mesenchymal-stem-cell-research-in-veterinary-medicine
#4
Mudasir Bashir Gugjoo, Amarpal, Vikash Chandra, Mohd Yaqoob Wani, Kuldeep Dhama, Gutulla Taru Sharma
BACKGROUND: The stem cells due to their unique characteristic features like self-renewal, multiplication, immuno-modulation and differentiation, are seen and hoped to bring new horizons in the field of biology, in general and medicine, in particular. OBJECTIVE: Among various stem cell types, currently mesenchymal stem cells (MSCs) are extensively studied in regenerative medicine owing to their readily available sources, easy harvesting and ability to differentiate both into mesodermal as well as non-mesodermal tissues with little associated ethical issues...
May 16, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29768544/response-to-different-benznidazole-doses-in-animal-models-of-chronic-phase-chagas-disease-a-critical-review
#5
Cauê Benito Scarim, Aline Rimoldi Ribeiro, João Aristeu da Rosa, Chung Man Chin
Chagas disease is a protozoan infection that was identified over a century ago. No drugs are available to treat the indeterminate and determinate chronic phases of the disease. Success of a drug design is dependent on correct biological evaluation. Concerning new drug designs for Chagas disease, it is essential to first identify the most effective, existing, experimental chronic protocols that can be used for comparison purposes. Here, we present a literature review regarding experimental models with chronic Chagas disease to evaluate the efficacy of benznidazole (BZN)...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29767367/a-review-of-transcriptome-analysis-in-pulmonary-vascular-diseases
#6
Dustin R Fraidenburg, Roberto F Machado
Transcriptome analysis is a powerful tool in the study of pulmonary vascular disease and pulmonary hypertension. Pulmonary hypertension is a disease process that consists of several unique pathologies sharing a common clinical definition, that of elevated pressure within the pulmonary circulation. As such, it has become increasingly important to identify both similarities and differences among the different classes of pulmonary hypertension. Transcriptome analysis has been an invaluable tool both in the basic science research on animal models as well as clinical research among the various different groups of pulmonary hypertension...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29759663/cellular-physiology-and-clinical-manifestations-of-fascicular-arrhythmias-in-normal-hearts
#7
REVIEW
Raphael K Sung, Penelope A Boyden, Melvin Scheinman
Fascicular ventricular arrhythmias represent a spectrum of ventricular tachycardias dependent on the specialized conduction system. Although they are more common in structurally abnormal hearts, there is an increasing body of literature describing their role in normal hearts. In this review, the authors present data from both basic and clinical research that explore the current understanding of idiopathic fascicular ventricular arrhythmias. Evaluation of the cellular electrophysiology of the Purkinje cells shows clear evidence of enhanced automaticity and triggered activity as potential mechanisms of arrhythmias...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759310/flavanols-are-potential-anti-obesity-agents-a-systematic-review-and-meta-analysis-of-controlled-clinical-trials
#8
M Akhlaghi, S Ghobadi, M Mohammad Hosseini, Z Gholami, F Mohammadian
BACKGROUND: The anti-obesity potential of flavonoids has been shown by animal and human studies. In this meta-analysis, we systematically reviewed controlled clinical trials and quantified the effects of flavonoids and flavonoid subclasses on obesity-related anthropometric measures. METHODS AND RESULTS: PubMed, EMBASE, Scopus, Web of Science, and ProQuest databases were searched to identify trials examining the effect of flavonoids on body mass index (BMI), waist circumference, and body fat percentage...
April 13, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29759021/alginate-ototoxicity-in-the-mouse-model
#9
Sameer A Alvi, Jennifer Nelson-Brantley, Hinrich Staecker
Objective To determine whether alginate exposure to the round window of the mouse causes any measurable ototoxicity. Study Design Prospective animal study. Setting Basic science laboratory affiliated with a tertiary care university medical center. Subjects and Methods After Institutional Animal Care and Use Committee approval, 5 adult mice were obtained and underwent bullostomy and round window niche application of alginate. Auditory brainstem response (ABR) tests were completed at baseline prior to the procedure and also 5, 14, and 30 days postprocedure...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29757366/a-systematic-review-and-meta-analysis-reveals-pervasive-effects-of-germline-mitochondrial-replacement-on-components-of-health
#10
Ralph Dobler, Damian K Dowling, Edward H Morrow, Klaus Reinhardt
BACKGROUND: Mitochondrial replacement, a form of nuclear transfer, has been proposed as a germline therapy to prevent the transmission of mitochondrial diseases. Mitochondrial replacement therapy has been licensed for clinical application in the UK, and already carried out in other countries, but little is known about negative or unintended effects on the health of offspring born using this technique. OBJECTIVE AND RATIONALE: Studies in invertebrate models have used techniques that achieve mitochondrial replacement to create offspring with novel combinations of mitochondrial and nuclear genotype...
May 11, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29753929/best-practices-for-developmental-toxicity-assessment-for-classification-and-labeling
#11
George Daston, Aldert Piersma, Leonello Attias, Manon Beekhuijzen, Connie Chen, Jennifer Foreman, Nina Hallmark, Isabelle Leconte
Many chemicals are going through a hazard-based classification and labeling process in Europe. Because of the significant public health implications, the best science must be applied in assessing developmental toxicity data. The European Teratology Society and Health and Environmental Sciences Institute co-organized a workshop to consider best practices, including data quality and consistency, interpretation of developmental effects in the presence of maternal toxicity, human relevance of animal data, and limits of chemical classes...
May 10, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29753798/sex-related-responses-after-traumatic-brain-injury-considerations-for-preclinical-modeling
#12
REVIEW
Claudia B Späni, David J Braun, Linda J Van Eldik
Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since men are more likely to experience a TBI because of more frequent participation in activities that increase risk of head injuries. This male bias is also reflected in preclinical research where mostly male animals have been used in basic and translational science. However, with an aging population in which TBI incidence is increasingly sex-independent due to falls, and increasing female participation in high-risk activities, the attention to potential sex differences in TBI responses and outcomes will become more important...
May 10, 2018: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29753786/affinity-capillary-electrophoresis-for-studying-interactions-in-life-sciences
#13
REVIEW
Mais Olabi, Matthias Stein, Hermann Wätzig
Affinity capillary electrophoresis (ACE) analyzes noncovalent interactions between ligands and analytes based on changes in their electrophoretic mobility. This technique has been widely used to investigate various biomolecules, mainly proteins, polysaccharides and hormones. ACE is becoming a technique of choice to validate high throughput screening results, since it is very predictively working in realistic and relevant media, e.g. in body fluids. It is highly recommended to incorporate ACE as a powerful analytical tool to properly prepare animal testing and preclinical studies...
May 10, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29753688/citrus-fruits-intake-and-oral-cancer-risk-a-systematic-review-and-meta-analysis
#14
REVIEW
Santa Cirmi, Michele Navarra, Jayne V Woodside, Marie M Cantwell
OBJECTIVE: To quantify the relationship between Citrus intake and risk of cancer of the oral cavity and pharynx. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Ovid MEDLINE, EMBASE, and Web of Science were searched until September 2017. Search terms included Citrus, Citrus aurantifolia, Citrus sinensis, Citrus paradisi, Citrus fruits, Citrus fruits extract, Citrus oil, fruits, oral cancer, mouth cancer, mouth neoplasm. STUDY SELECTION: The selection of studies and the systematic review were carried out in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement...
May 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29743979/mesenchymal-stromal-cell-therapy-for-pancreatitis-a-systematic-review
#15
REVIEW
Sara M Ahmed, Mahmoud Morsi, Nehal I Ghoneim, Mohamed M Abdel-Daim, Nagwa El-Badri
Background: Based on animal studies, adult mesenchymal stromal cells (MSCs) are promising for the treatment of pancreatitis. However, the best type of this form of cell therapy and its mechanism of action remain unclear. Methods: We searched the PubMed, Web of Science, Scopus, Google Scholar, and Clinical Trials.gov websites for studies using MSCs as a therapy for both acute and chronic pancreatitis published until September 2017. Results: We identified 276 publications; of these publications, 18 met our inclusion criteria...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29738847/ethnopharmacological-uses-phytochemistry-biological-activities-and-therapeutic-applications-of-alpinia-oxyphylla-miquel-a-review
#16
REVIEW
Qiao Zhang, Yunliang Zheng, Xingjiang Hu, Xiaolong Hu, Wenwen Lv, Duo Lv, Jinjin Chen, Minglan Wu, Qichao Song, Jianzhong Shentu
ETHNOPHARMACOLOGICAL USAGES: Fructus Alpiniae oxyphyllae (A. oxyphylla) is an important medicinal plant that is used not only as an edible fruit, but also as an important traditional medicine for benefiting cognitive performance and alleviating a wide spectrum of diseases. Such as; warming kidney, securing essence and arresting polyuria, as well as warming the spleen and stopping diarrhea and saliva. AIMS: The purpose of this review is to provide updated, comprehensive and categorized information on the traditional uses, phytochemistry and pharmacological research of A...
May 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29738328/persistent-postsurgical-pain-pathophysiology-and-preventative-pharmacologic-considerations
#17
Philippe Richebé, Xavier Capdevila, Cyril Rivat
The development of chronic pain is considered a major complication after surgery. Basic science research in animal models helps us understand the transition from acute to chronic pain by identifying the numerous molecular and cellular changes that occur in the peripheral and central nervous systems. It is now well recognized that inflammation and nerve injury lead to long-term synaptic plasticity that amplifies and also maintains pain signaling, a phenomenon referred to as pain sensitization. In the context of surgery in humans, pain sensitization is both responsible for an increase in postoperative pain via the expression of wound hyperalgesia and considered a critical factor for the development of persistent postsurgical pain...
May 7, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29736899/adaptive-memory-is-the-animacy-effect-on-memory-due-to-emotional-arousal
#18
Martin J Meinhardt, Raoul Bell, Axel Buchner, Jan P Röer
Animate entities are often better remembered than inanimate ones. The proximal mechanisms underlying this animacy effect on recall are unclear. In two experiments, we tested whether the animacy effect is due to emotional arousal. Experiment 1 revealed that translations of the animate words used in the pioneering study of Nairne et al. (Psychological science, 24, 2099-2105, 2013) were perceived as being more arousing than translations of the inanimate words, suggesting that animacy might have been confounded with arousal in previous studies...
May 7, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29732472/how-training-citizen-scientists-affects-the-accuracy-and-precision-of-phenological-data
#19
Richard E Feldman, Irma Žemaitė, Abraham J Miller-Rushing
Monitoring plant and animal phenology is a critical step to anticipating and predicting changes in species interactions and biodiversity. Because phenology necessarily involves frequent and repeated observations over time, citizen scientists have become a vital part of collecting phenological data. However, there is still concern over the accuracy and precision of citizen science data. It is possible that training citizen scientists can improve data quality though there are few comparisons of trained and untrained citizen scientists in the ability of each to accurately and precisely measure phenology...
May 7, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29730284/measuring-corticosterone-concentrations-over-a-physiological-dynamic-range-in-female-rats
#20
Mandakh Bekhbat, Erica R Glasper, Sydney A Rowson, Sean D Kelly, Gretchen N Neigh
Accurate assessment of plasma corticosterone, the primary stress hormone in rodents, is an essential part of characterizing the stress response in experimental animals. To this end, both enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA) remain widely used. However, considerable assay-specific variability exists among commercially available corticosterone assays due to differing assay principles, detection methods, range, and sensitivity. While technical comparisons of commercially available corticosterone assays have previously been conducted, the ability to detect acute stress-induced endocrine changes has not been compared among these methods to date...
May 3, 2018: Physiology & Behavior
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