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Vitamin D retinopathy

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https://www.readbyqxmd.com/read/29760812/effects-of-glucan-and-vitamin-d-supplementation-on-obesity-and-lipid-metabolism-in-diabetic-retinopathy
#1
Martina Závorková, Vaclav Vetvicka, Josef Richter, Vlastimil Kral, Ivana Liehnova, Dobiasova L Rajnohova
Background: Diabetes mellitus is a chronic disease manifested by an increase of blood glucose. Objective: To evaluate the effects of glucan and vitamin D supplementation in patients with diabetic retinopathy. Method: We evaluated the effects of 3-month supplementation with glucan and vitamin D in 54 patients with diabetic retinopathy. We measured levels of vitamin D, cholesterol, HDL cholesterol, and triglycerides. Results: The supplementation strongly decreased the cholesterol levels and improved the levels of HDL cholesterol...
2018: Open Biochemistry Journal
https://www.readbyqxmd.com/read/29682582/vitamin-d-3-protects-against-diabetic-retinopathy-by-inhibiting-high-glucose-induced-activation-of-the-ros-txnip-nlrp3-inflammasome-pathway
#2
Li Lu, Qianyi Lu, Wei Chen, Jingwen Li, Chunxia Li, Zhi Zheng
Purpose: This study aimed to evaluate the mechanisms underlying the effects of 1,25-dihydroxyvitamin D (vitamin D3 ) on diabetes-induced retinal vascular damage and retinal vascular endothelial cell apoptosis. Methods: Diabetic and control rats were randomly assigned to receive vitamin D3 or vehicle for 6 months. Additionally, human retinal microvascular endothelial cells (HRMECs) were incubated in normal or high-glucose medium with or without vitamin D3 . Morphological changes in retinal tissues and retinal vascular permeability were examined, and cellular apoptosis was detected by fluorescence staining...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29540175/complex-genetic-architecture-in-severe-hypobetalipoproteinemia
#3
Linda R Wang, Adam D McIntyre, Robert A Hegele
BACKGROUND: Abetalipoproteinemia and homozygous hypobetalipoproteinemia are classical Mendelian autosomal recessive and co-dominant conditions, respectively, which are phenotypically similar and are usually caused by bi-allelic mutations in MTTP and APOB genes, respectively. Instances of more complex patterns of genomic variants resulting in this distinct phenotype have not been reported. METHODS: A 43 year-old male had a longstanding severe deficiency of apolipoprotein (apo) B-containing lipoproteins and circulating fat soluble vitamins consistent with either abetalipoproteinemia or homozygous familial hypobetalipoproteinemia (FHBL)...
March 14, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29518485/association-of-serum-vitamin-d-levels-and-diabetic-retinopathy-in-asian-indians-with-type-2-diabetes
#4
Beteal Ashinne, Ramachandran Rajalakshmi, Ranjit M Anjana, K M Venkat Narayan, Ramamoorthy Jayashri, Viswanathan Mohan, Andrew M Hendrick
BACKGROUND: Vitamin D deficiency (VDD) is a condition that has been associated with diabetic retinopathy (DR) in various populations, but has not been studied in Asian Indians. AIMS: To evaluate the association of serum 25-hydroxyvitamin D (25(OH)D) levels with presence and severity of DR among Asian Indians with type 2 diabetes. METHODS: We collected information on individuals with type 2 diabetes that received care at a tertiary diabetes centre in India, between 2012 and 2015...
May 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29506625/vdbp-vdr-mutations-and-other-factors-related-with-vitamin-d-metabolism-may-be-associated-with-type-1-diabetes-mellitus
#5
Deniz Kirac, Ceyda Dincer Yazan, Hazal Gezmis, Ali Yaman, Goncagul Haklar, Onder Sirikci, Elif Cigdem Altunok, Oguzhan Deyneli
Type 1 diabetes mellitus (T1DM) is an insulin dependent autoimmune disorder resulting the progressive destruction of pancreatic beta cells. Another possible factor considered to be related with T1DM is vitamin D deficiency. Therefore in this study it was aimed to investigate the associations between T1DM, vitamin D binding protein (VDBP) and vitamin D receptor (VDR) gene mutations which are related with vitamin D metabolism. Fifty five T1DM paitents and 40 healthy volunteers were recruited to the study. FokI (rs2228570), BsmI (rs1544410) mutations in VDR; rs4588 and rs7041 polymorphisms in VDBP were investigated with real-time polymerase chain reaction (RT-PCR)...
February 28, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29324740/dietary-intake-and-diabetic-retinopathy-a-systematic-review
#6
Mark Y Z Wong, Ryan E K Man, Eva K Fenwick, Preeti Gupta, Ling-Jun Li, Rob M van Dam, Mary F Chong, Ecosse L Lamoureux
INTRODUCTION: The evidence linking dietary intake with diabetic retinopathy (DR) is growing but unclear. We conducted a systematic review of the association between dietary intake and DR. METHODS: We systematically searched PubMed, Embase, Medline, and the Cochrane Central register of controlled trials, for publications between January 1967 and January 2017 using standardized criteria for diet and DR. Interventional and observational studies investigating micro- and macro-nutrient intakes; food and beverage consumptions; and dietary patterns were included...
2018: PloS One
https://www.readbyqxmd.com/read/29204902/diet-and-risk-of-diabetic-retinopathy-a-systematic-review
#7
REVIEW
Courtney Dow, Francesca Mancini, Kalina Rajaobelina, Marie-Christine Boutron-Ruault, Beverley Balkau, Fabrice Bonnet, Guy Fagherazzi
Diabetic retinopathy is a microvascular complication of diabetes that threatens all individuals with diabetes, leading to vision loss or blindness if left untreated. It is frequently associated with diabetic macular edema, which can occur at any point during the development of diabetic retinopathy. The key factors known to lead to its development include hyperglycemia, hypertension, and the duration of diabetes. Though the diet is important in the development of diabetes, its role in diabetic retinopathy has not been clearly identified...
December 4, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29167189/photobiomodulation-inhibits-long-term-structural-and-functional-lesions-of-diabetic-retinopathy
#8
Yan Cheng, Yunpeng Du, Haitao Liu, Jie Tang, Alex Veenstra, Timothy S Kern
Previous studies demonstrated that brief (3 to 4 min) daily application of light at 670 nm to diabetic rodents inhibited molecular and pathophysiologic processes implicated in the pathogenesis of diabetic retinopathy (DR) and reversed diabetic macular edema in small numbers of patients studied. Whether or not this therapy would inhibit the neural and vascular lesions that characterize the early stages of the retinopathy was unknown. We administered photobiomodulation (PBM) therapy daily for 8 months to streptozotocin-diabetic mice and assessed effects of PBM on visual function, retinal capillary permeability, and capillary degeneration using published methods...
February 2018: Diabetes
https://www.readbyqxmd.com/read/29074012/relationship-between-vitamin-d-deficiency-and-diabetic-retinopathy-a-meta-analysis
#9
Jason Zhang, Sikarin Upala, Anawin Sanguankeo
OBJECTIVE: The purpose of this study was to evaluate the evidence for an association between diabetic retinopathy (DR) and vitamin D deficiency. DESIGN: Meta-analysis. METHODS: We included 14 observational studies with 10 007 participants who had undergone assessment for both DR and vitamin D deficiency. Pooled odds ratios (ORs) and 95% CIs were calculated using a random-effect, Mantel-Haenszel analysis. RESULTS: There was a statistically significant association between DR and vitamin D deficiency with an overall pooled OR of 1...
November 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28899218/relationship-between-serum-25-hydroxy-vitamin-d-levels-and-retinopathy-of-prematurity
#10
Emrah Utku Kabataş, Nurdan Fettah Dinlen, Ayşegül Zenciroğlu, Dilek Dilli, Serdar Beken, Nurullah Okumuş
Aim To evaluate the relationship between serum 25-hydroxy vitamin D, 25 (OH) D, levels and retinopathy of prematurity. Methods and Results Serum 25 (OH) D levels were measured in 97 very low birth weight infants, prior to vitamin D supplementation. The development of retinopathy of prematurity and its treatment requirement were evaluated. At follow-up, retinopathy of prematurity developed in 71 (73.2%) infants. Serum 25 (OH) D levels were significantly lower in infants with retinopathy of prematurity than ones without retinopathy of prematurity ( P < 0...
November 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28604686/glycated-hemoglobin-a1c-and-vitamin-d-and-their-association-with-diabetic-retinopathy-severity
#11
M Long, C Wang, D Liu
OBJECTIVES: This retrospective, population-based, cross-sectional study evaluated the association between vitamin D deficiency and retinopathy severity in diabetic patients with poorly or well controlled glycaemia. Other potential risk factors for diabetic retinopathy severity were also assessed. METHODS: The National Health and Nutrition Examination Survey (NHANES) 2005-2008 data were used for the study. Outcomes assessed included retinopathy severity, HbA1c levels, socioeconomic, behavioral, and biological factors...
June 12, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28547797/vitamin-d-receptor-agonists-regulate-ocular-developmental-angiogenesis-and-modulate-expression-of-dre-mir-21-and-vegf
#12
Stephanie L Merrigan, Breandán N Kennedy
BACKGROUND AND PURPOSE: Pathological growth of ocular vasculature networks can underpin visual impairment in neovascular age-related macular degeneration, proliferative diabetic retinopathy and retinopathy of prematurity. Our aim was to uncover novel pharmacological regulators of ocular angiogenesis by phenotype-based screening in zebrafish. EXPERIMENTAL APPROACH: A bioactive chemical library of 465 drugs was screened to identify small molecule inhibitors of ocular hyaloid vasculature (HV) angiogenesis in zebrafish larvae...
August 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28514126/-haptoglobin-polymorphism-as-an-independent-predictor-of-diabetic-nephropathy-and-retinopathy
#13
Inbal Dahan, Nadia Thauho, Farid Nakhoul, Nakhoul Nakhoul, Hanin Jabaly, Evgeny Farber
The antioxidant protein haptoglobin (Hp) plays a major role in the development of diabetic complications such as diabetic nephropathy and retinopathy. In humans, two alleles of Hp were identified: 1 and 2 with three possible genotypes: 1-1, 2-1, and 2-2. The Hp protein products differ in their biochemical and biophysical properties, such as their antioxidant capacity. The Hp1 protein is superior to the Hp2 protein in binding to free hemoglobin and neutralizing its oxidative potential and the accompanying renal and retinal injury...
July 2016: Harefuah
https://www.readbyqxmd.com/read/28502635/identification-of-vitreous-proteins-in-retinopathy-of-prematurity
#14
Koji Sugioka, Akio Saito, Shunji Kusaka, Kazuki Kuniyoshi, Yoshikazu Shimomura
Retinopathy of prematurity (ROP) is a disorder of blood vessels in the retina developed in premature infants and the leading cause of the blindness in children. Proteomic analysis was performed to identify vitreous proteins specific to patients with ROP. Vitreous humor samples were obtained from three patients with ROP and two patients with congenital cataract, the latter included as a control group. The vitreous samples were separated by 2D-PAGE and the proteins running as definitive spots were identified by MALDI-TOF MS spectrometry...
July 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28457295/relationship-between-vitamin-d-deficiency-and-diabetic-retinopathy-a-meta-analysis
#15
REVIEW
Jason Zhang, Sikarin Upala, Anawin Sanguankeo
OBJECTIVE: The purpose of this study was to evaluate the evidence for an association between diabetic retinopathy (DR) and vitamin D deficiency. DESIGN: Meta-analysis. METHODS: We included 14 observational studies with 10 007 participants who had undergone assessment for both DR and vitamin D deficiency. Pooled odds ratios (ORs) and 95% CIs were calculated using a random-effect, Mantel-Haenszel analysis. RESULTS: There was a statistically significant association between DR and vitamin D deficiency with an overall pooled OR of 1...
April 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28335514/the-association-between-vitamin-d-deficiency-and-diabetic-retinopathy-in-type-2-diabetes-a-meta-analysis-of-observational-studies
#16
Bang-An Luo, Fan Gao, Lu-Lu Qin
Emerging evidence from in vivo and in vitro studies have shown that vitamin D may play an important role in the development of diabetic retinopathy (DR), but individually published studies showed inconclusive results. The aim of this study was to quantitatively summarize the association between vitamin D and the risk of diabetic retinopathy. We conducted a systematic literature search of Pubmed, Medline, and EMBASE updated in September 2016 with the following keywords: "vitamin D" or "cholecalciferol" or "25-hydroxyvitamin D" or "25(OH)D" in combination with "diabetic retinopathy" or "DR"...
March 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28259209/role-of-vitamin-d-in-intima-media-thickness-in-patients-with-type-1-diabetes-mellitus
#17
Bengur Taskiran, Guven B Cansu, Eylem Bahadir, Ruya Mutluay
Increased carotid intima media thickness indicates subclinical atherosclerosis. We evaluated the relation between vitamin D level and intima media thickness in patients with type 1 DM. 93 patients (female/male: 48/45, aged 31.5 ± 11.9 years, A1c 9.48 ± 2.43, vitamin D [15.9 (12.1-19.2)]) with type 1 DM were included into the study. Common carotid artery IMT was measured by real time B mode ultrasonography (MyLab 70 XVG, Esaote SpA, Genoa, Italy). Vitamin D was measured using radioimmunassay. Male and female patients (n = 14, 15%) had similar rates of plaque presence (p = 0...
April 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/27930528/vitamin-d-and-retinal-microvascular-damage-the-rotterdam-study
#18
Unal Mutlu, M Arfan Ikram, Albert Hofman, Paulus T V M de Jong, Andre G Uitterlinden, Caroline C W Klaver, M Kamran Ikram
Vitamin D has been linked to various cardiovascular risk factors including indices of large-vessel disease. However, it remains unclear whether vitamin D is also associated with microvascular damage. In a community-dwelling population, we studied associations between vitamin D serum levels and retinal microvascular damage defined as retinopathy signs, narrower arterioles, and wider venules.From the population-based Rotterdam Study, we included 5675 participants (age ≥45 years) with vitamin D data and gradable retinal photographs...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27891515/the-association-between-vdr-gene-polymorphisms-and-diabetic-retinopathy-susceptibility-a-systematic-review-and-meta-analysis
#19
REVIEW
Yun Zhang, Wei Xia, Ping Lu, Huijuan Yuan
Aims. Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results. A systematic meta-analysis was undertaken to clarify this topic. Methods. A systematic search of electronic databases (PubMed, EMBASE, and CNKI) was carried out until March 31, 2016. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. Results. A total of 7 studies fulfilling the inclusion criteria were included in this meta-analysis (649 cases and 707 controls)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27728120/estimation-of-serum-vitamin-d-levels-in-diabetics-and-its-correlation-with-diabetic-retinopathy
#20
Sourabh Jain, Anurag Chaurasia, Shailendra Manjhvar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
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