keyword
https://read.qxmd.com/read/38508994/no-causal-association-between-serum-vitamin-d-levels-and-diabetes-retinopathy-a-mendelian-randomization-analysis
#1
JOURNAL ARTICLE
Chengcheng Huang, Dan Luo, Mingliang Sun, Guowei Fang, Mengjuan Wei, Yufei Zhang, Jingwu Wang, Yanqin Huang
BACKGROUND AND AIM: Diabetes retinopathy (DR) is a common microvascular complication of diabetes, and it is the main cause of global vision loss. The current observational research results show that the causal relationship between Vitamin D and DR is still controversial. Therefore, we conducted a Mendelian randomization study to determine the potential causal relationship between serum 25-hydroxyvitamin D 25(OH)D and DR. METHODS AND RESULTS: In this study, we selected aggregated data on serum 25(OH)D levels (GWAS ID: ebi-a-GCST90000615) and DR (GWAS ID: finn-b-DM_RETINOPATHY) from a large-scale GWAS database...
February 5, 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/38469994/serum-vitamin-d-is-substantially-reduced-and-predicts-flares-in-diabetic-retinopathy-patients
#2
JOURNAL ARTICLE
Yong Zhuang, Zihao Zhuang, Qingyan Cai, Xin Hu, Huibin Huang
AIMS/INTRODUCTION: Research has suggested that vitamin D deficiency is associated with diabetic retinopathy (DR). Our study aimed to determine whether vitamin D deficiency is the cause of diabetic retinopathy or if diabetic retinopathy reduces vitamin D levels. MATERIALS AND METHODS: Participants with type-2 diabetes were recruited for this prospective observational clinical study and were divided into a diabetic group without retinopathy and a diabetic group with retinopathy, with additional healthy volunteers serving as a control group...
March 12, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38315019/alleviation-of-diabetic-retinopathy-by-glucose-triggered-delivery-of-vitamin-d-via-dextran-gated-functionalized-mesoporous-silica-nanoparticles
#3
JOURNAL ARTICLE
Sanjib Sarkar, Narin Osman, Thilini Thrimawithana, Sawlang Borsingh Wann, Jatin Kalita, Prasenjit Manna
Diabetic retinopathy (DR) is the most common retinal disorder, developed in 35% of patients with diabetes mellitus. Lower serum levels of 25-hydroxyvitamin D are associated with the increased risk of developing DR. High doses of the active form of vitamin D (VD), on the contrary, for a long period of time may lead to hypercalcemia and an imbalance in the regulation of bone metabolism. Herein, we studied the efficacy of dextran-gated carboxyphenylboronic acid (CPBA)-functionalized mesoporous silica nanoparticles (MSNs) for glucose-sensitive delivery of 1,25-dihydroxyvitamin D3 to modulate cellular oxidative stress and inflammation for managing DR...
February 5, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38275038/diabetic-retinopathy-leading-to-blindness-a-review
#4
JOURNAL ARTICLE
Amandeep Kaur, Ranjeet Kumar, Amit Sharma
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes that damages the retina, leading to blindness. People with type 1 diabetes are at greater risk of developing DR than people with type 2 diabetes. Diabetic retinopathy may be divided into two primary categories: proliferative diabetic retinopathy (PDR) and non-proliferative diabetic retinopathy (NPDR). There are multiple risk factors for the onset and progression of diabetic retinopathy, such as hypertension, obesity, smoking, duration of diabetes, and genetics...
January 24, 2024: Current Diabetes Reviews
https://read.qxmd.com/read/38220370/is-vitamin-d-deficiency-associated-with-retinopathy-in-type-2-diabetes-mellitus-a-case-control-study
#5
JOURNAL ARTICLE
Maryam Zahedi, Mohammad Mehdi Motahari, Farima Fakhri, Nastaran Moeini Aphshari, Shayan Poursharif, Romina Jahed, Omid Nikpayam
BACKGROUND AND AIMS: This study aimed to determine the associations between vitamin D deficiency and diabetic retinopathy (DR) progression risk in type 2 diabetes mellitus (T2DM) patients. METHODS: This is a case-control study that enrolled 201 diabetic retinopathy (DR) patients as case and 201 T2DM without DR as a control. Demographic variables were obtained during an interview using a questionnaire, furthermore, anthropometric measures were evaluated based on the standard protocol...
February 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38130469/dietary-consumption-on-glycemic-control-among-prediabetes-a-review-of-the-literature
#6
REVIEW
Sopida Thipsawat
INTRODUCTION: Prediabetes is a condition that, if left unaddressed, can lead to various complications, such as neuropathy, retinopathy, and nephropathy. Among the critical factors contributing to the development of type 2 diabetes mellitus, dietary choices stand out as particularly significant. OBJECTIVE: Consequently, our objective is to examine the latest research findings concerning dietary consumption and its impact on glycemic control in individuals with prediabetes...
2023: SAGE Open Nursing
https://read.qxmd.com/read/37908990/limited-joint-mobility-in-type-1-diabetes-diabetic-cheiroarthropathy-a-neglected-entity
#7
Jayshree Swain, Brij Teli, Abhay Sahoo, Lavanya Kasukurti
Musculoskeletal disorders are common in type 1 and type 2 diabetes mellitus. Among them, diabetic cheiroarthropathy (DCA), more commonly seen in type 1 diabetes, is a late complication that often causes physical and emotional disturbance. DCA, characterized by movement restrictions in the small joints of hands, is usually a clinical diagnosis and bears significance owing to the functional hand disabilities that it causes and its association with various microvascular complications, most importantly retinopathy...
July 2023: JCEM Case Rep
https://read.qxmd.com/read/37845735/cardiovascular-and-microvascular-outcomes-according-to-vitamin-d-level-and-genetic-variants-among-individuals-with-prediabetes-a-prospective-study
#8
JOURNAL ARTICLE
Pingting Zhong, Zhuoting Zhu, Yunlong Wang, Wenyong Huang, Mingguang He, Wei Wang
BACKGROUND: Whether serum vitamin D mediate vascular diseases in prediabetic populations remains unclear. This study aimed to determine the associations between circulating 25-hydroxyvitamin D [25(OH)D] levels and vitamin D receptor (VDR) polymorphisms with the risk of macrovascular complications, including myocardial infarction and stroke, and microvascular complications such as diabetic nephropathy and retinopathy, among adults with prediabetes. METHODS: Participants with prediabetes in UK Biobank were included (N = 56,387)...
October 16, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/37798019/vitamin-d-deficiency-and-its-associated-factors-among-patients-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Mitku Mammo Taderegew, Gashaw Garedew Woldeamanuel, Alemayehu Wondie, Atsede Getawey, Abera Nesiru Abegaz, Fentahun Adane
OBJECTIVE: The study intended to assess the pooled prevalence of vitamin D deficiency (VDD) and its associated factors among patients with type 2 diabetes mellitus (T2DM). DESIGN: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were employed to plan and conduct this systematic review and meta-analysis. DATA SOURCES: PubMed, Medline, Google Scholar, Web of Science, Science Direct and the Worldwide Science database were searched from their inception to 31 January 2023...
October 5, 2023: BMJ Open
https://read.qxmd.com/read/37797989/8%C3%A2-unexpected-retinopathy-in-a-patient-presenting-with-bilateral-optic-disc-swelling
#10
JOURNAL ARTICLE
G Kiray, V Panteli, N Enright, S Handley, O Marmoy, D Thompson, R Henderson
A 12-year-old boy presented with 5 day history of blurry vision, 'wobbly eyes', tinnitus and difficulty seeing at night. Local ophthalmology noted bilateral optic disc swelling and referred him urgently for neurological investigations.Clinical Findings: At presentation VA was RE 0.00 and LE 0.2 with normal Ishihara colour vision. His extraocular movements were full without manifest strabismus. Fundoscopy showed bilateral optic disc swelling. Electrophysiology unexpectedly revealed a functionally cone isolated retina with markedly abnormal rod function...
October 2023: BMJ Open Ophthalmology
https://read.qxmd.com/read/37793365/predictors-of-hyporesponsiveness-to-erythropoiesis-stimulating-agents-in-patients-with-non-dialysis-dependent-chronic-kidney-disease-radiance-ckd-study
#11
RANDOMIZED CONTROLLED TRIAL
Kaori Mase, Kunihiro Yamagata, Hiroyasu Yamamoto, Kazuhiko Tsuruya, Hiroki Hase, Shinichi Nishi, Masaomi Nangaku, Takashi Wada, Terumasa Hayashi, Yukari Uemura, Hideki Hirakata
INTRODUCTION: Hyporesponsiveness to erythropoiesis-stimulating agents (ESAs) has been associated with increased mortality and cardiovascular events in patients with chronic kidney disease. We hypothesized that the prediction of ESA resistance during ESA administration would be very useful in deciding on a treatment plan. METHODS: Patients enrolled in a randomized controlled trial to evaluate renal prognosis in anemic patients with non-dialysis-dependent chronic kidney disease with hyporesponsiveness to ESA were included; the patients had different target hemoglobin levels...
2023: American Journal of Nephrology
https://read.qxmd.com/read/37762856/do-glp-1-analogs-have-a-place-in-the-treatment-of-pcos-new-insights-and-promising-therapies
#12
REVIEW
Aleksandra Szczesnowicz, Anna Szeliga, Olga Niwczyk, Gregory Bala, Blazej Meczekalski
Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. This condition is characterized by hyperandrogenism and either oligo- or anovulation. PCOS patients often present comorbidities such as obesity, insulin resistance, impaired glucose metabolism, dyslipidemia, hypertension, metabolic syndrome, and an increased risk of diabetes. Given the profound implications of metabolic impairment in PCOS, the accurate diagnosis and management of these facets are imperative. The first-line approach to treatment involves lifestyle modifications, including dietary adjustments and exercise aimed at achieving weight loss, a strategy consistently emphasized across the literature...
September 12, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37759071/correlation-between-tear-levels-of-vascular-endothelial-growth-factor-and-vitamin-d-at-retinopathy-of-prematurity-stages-in-preterm-infants
#13
JOURNAL ARTICLE
Ponnalagu Murugeswari, Anand Vinekar, S Grace Prakalapakorn, Venkata Ramana Anandula, Murali Subramani, Tanuja Arun Vaidya, Archana Padmanabhan Nair, Chaitra Jayadev, Arkasubhra Ghosh, Govindasamy Kumaramanickavel, Rohit Shetty, Debashish Das
Deregulation of vascular endothelial growth factor (VEGF) levels leads to retinopathy of prematurity (ROP). Vitamin D (VIT-D) is known to regulate VEGF in an oxygen dependent manner. The purpose of this study was to correlate tear levels of VEGF and VIT-D with different ROP stages in preterm infants. In this prospective cross-sectional study, we enrolled 104 pre-term infants. They were grouped into: Group-1 (Classical ROP) and Group-2 (Aggressive ROP), which were further subdivided into Group-1A (progressing), Group-1B (regressing), Group-2A (pre-treatment), and Group-2B (post-treatment)...
September 27, 2023: Scientific Reports
https://read.qxmd.com/read/37691189/managing-diabetic-complications-with-alternative-therapeutic-strategies
#14
JOURNAL ARTICLE
Shobhit Prakash Srivastava, Pawan Upadhyay, Shibu Das, Neha Tiwari, Sudhanshu Mishra, Shivendra Mani Tripathi
Diabetes is a chronic metabolic disease affecting millions worldwide. It is characterized by a lack of insulin production or impaired insulin function, leading to elevated blood glucose levels. Conventional treatment methods for diabetes management typically include lifestyle changes and medications. However, alternative therapies have gained attention in recent years, including traditional medicine containing bioactive compounds, supplements like vitamin D and Omega-3 fatty acids, aromatherapy, and homeopathy...
September 7, 2023: Current Diabetes Reviews
https://read.qxmd.com/read/37569392/vitamin-d-and-diabetic-retinopathy
#15
REVIEW
Antonela Gverović Antunica, Ljubo Znaor, Mira Ivanković, Velibor Puzović, Irena Marković, Snježana Kaštelan
Diabetic retinopathy (DR) is the most common eye disease complication of diabetes, and hypovitaminosis D is mentioned as one of the risk factors. Vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol) are the best-known forms of vitamin D. Calcitriol (1,25-dihydroxycholecalciferol) is the active form of vitamin D, with the sun being one of its main sources. Vitamin D is synthesized in the skin by exposure to sunlight without protective factors, but care must be taken to avoid the development of sunburn...
July 27, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37337761/vitamin-d-and-diabetic-peripheral-neuropathy-a-multi-centre-nerve-conduction-study-among-chinese-patients-with-type-2-diabetes
#16
JOURNAL ARTICLE
Chunyang Pang, Huan Yu, Yunlei Cai, Mengwan Song, Fei Feng, Lingfei Gao, Kezheng Li, Yinuo Chen, Jiali Xie, Yifan Cheng, Er Lin, Xinnan Pan, Wanli Zhang, Binbin Deng
AIMS: Increasing numbers of reports link vitamin D deficiency to diabetic peripheral neuropathy (DPN), yet evidence regarding neurological deficits and electromyogram is scarce. The present multi-centre study sought to investigate these associations based on objective quantifications. MATERIALS AND METHODS: Information on DPN-related symptoms, signs, all diabetic microvascular complications, and nerve conduction abilities (quantified by nerve conduction amplitude and velocity, F-wave minimum latency (FML) of peripheral nerves) were collected from a derivation cohort of 1192 patients with type 2 diabetes (T2D)...
June 20, 2023: Diabetes/metabolism Research and Reviews
https://read.qxmd.com/read/37313088/estimation-of-vitamin-d-levels-in-patients-with-retinal-vein-occlusions-and-a-comparison-with-age-matched-control-groups
#17
JOURNAL ARTICLE
Varsha Kandambeth, Prachee Nagrale, Sachin Daigavane
Background In the older population, retinal vein occlusion (RVO) is a major contributor to vision loss and blindness. RVO is the second most common form of retinal vascular disease, following diabetic retinopathy. On the other hand, there is a paucity of studies on vitamin D insufficiency and its influence on the causation of RVOs. The goal of this study is to demonstrate a link between vitamin D levels of individuals in rural India who have RVOs. Methods This study is a hospital-based prospective case-control study...
May 2023: Curēus
https://read.qxmd.com/read/37085359/vitamin-d-deficiency-and-diabetic-retinopathy-risk
#18
JOURNAL ARTICLE
S Navaei, S Nazemi, M H Emamian, H Hashemi, A Fotouhi
PURPOSE: Vitamin D deficiency may play an important role in the development and progression of diabetic retinopathy. The present study aimed to assess the relationship between vitamin D deficiency and the likelihood of diabetic retinopathy. METHODS: This nested case-control study was conducted on all type II diabetic patients among the participants of the third phase of the Shahroud eye cohort study. Overall, 278 patients aged 50 to 74 years, 101 in the case group (diabetic retinopathy) and 178 in the control group (diabetic without retinopathy), were assessed...
April 19, 2023: Journal Français D'ophtalmologie
https://read.qxmd.com/read/37077224/effects-of-methylenetetrahydrofolate-reductase-mthfr-polymorphisms-on-retinal-tissue-perfusion-in-mild-diabetic-retinopathy-patients-receiving-the-medical-food-ocufolin-%C3%A2
#19
JOURNAL ARTICLE
Hong Jiang, Zhiping Liu, Justin H Townsend, Jianhua Wang
PURPOSE: We evaluate the effects of methylenetetrahydrofolate reductase ( MTHFR) polymorphisms on retinal tissue perfusion in patients with mild diabetic retinopathy (DR + PM) taking the medical food, Ocufolin® , for 6 months. METHODS: Prospective, case-controlled study. Eight early diabetic retinopathy patients with common reduced function MTHFR polymorphisms (DR+PM) and 15 normal controls (NC) were recruited. MTHFR polymorphisms were subtyped as normal, C677T , or A1298C ...
2023: Clinical Ophthalmology
https://read.qxmd.com/read/37002758/role-of-vitamin-b12-deficiency-and-hyperhomocysteinemia-in-diabetic-retinopathy
#20
JOURNAL ARTICLE
P R Debnath, D K Debnath, A F Haque, M Mohammuddunnobi, N C Bhowmik
Diabetic retinopathy (DR) is one of the most important causes of preventable visual impairment among patients of working age and leading cause of blindness. Deficiency of vitamin B12 and folate has been associated with increased serum homocysteine (Hcy) levels. This study was done to find out the role of vitamin B12 and Hyperhomocysteine (HHcy) in Diabetic retinopathy. The present study is a hospital-based case-control study conducted during over a period of 12 months from January 2019 to December 2019 study conducted in the Department of Ophthalmology at BIRDEM General Hospital, Dhaka, Bangladesh consisting of 100 Type 2 DM patients either with or without retinopathy (DR, n=50 and DNR, n=50, respectively)...
April 2023: Mymensingh Medical Journal: MMJ
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