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Vitamin D retinopathy

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https://www.readbyqxmd.com/read/27891515/the-association-between-vdr-gene-polymorphisms-and-diabetic-retinopathy-susceptibility-a-systematic-review-and-meta-analysis
#1
Yun Zhang, Wei Xia, Ping Lu, Huijuan Yuan
Aims. Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results. A systematic meta-analysis was undertaken to clarify this topic. Methods. A systematic search of electronic databases (PubMed, EMBASE, and CNKI) was carried out until March 31, 2016. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. Results. A total of 7 studies fulfilling the inclusion criteria were included in this meta-analysis (649 cases and 707 controls)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27728120/estimation-of-serum-vitamin-d-levels-in-diabetics-and-its-correlation-with-diabetic-retinopathy
#2
Sourabh Jain, Anurag Chaurasia, Shailendra Manjhvar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27614865/interaction-between-diabetes-mellitus-and-hypertension-on-risk-of-hearing-loss-in-highly-endogamous-population
#3
Abdulbari Bener, Abdulla O A A Al-Hamaq, Khalid Abdulhadi, Ahmed H Salahaldin, Loida Gansan
AIM: The aim of this study was to determine the prevalence of hearing loss and its association with type 2 diabetes mellitus (T2DM) in a highly endogamous population. DESIGN: This is a cross-sectional study. SETTING: The present study is carried out in Ear Nose Throat (ENT) and Endocrinology outpatient clinics of the Hamad General and Rumeilah Hospitals, Hamad Medical Corporation. SUBJECTS: All subjects aged between 20 and 59 years who visited the Endocrinology and ENT outpatient clinics of the Hamad Medical Corporation with hearing difficulty were included in this study during the period from January 2013 to July 2014...
September 5, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27586865/adequate-vitamin-d-status-is-associated-with-the-reduced-odds-of-prevalent-diabetic-retinopathy-in-african-americans-and-caucasians
#4
Amy E Millen, Michelle W Sahli, Jing Nie, Michael J LaMonte, Pamela L Lutsey, Barbara E K Klein, Julie A Mares, Kirstin J Meyers, Christopher A Andrews, Ronald Klein
BACKGROUND: Vitamin D status has been hypothesized to protect against development of diabetic retinopathy via its anti-inflammatory and anti-angiogenic properties. Additionally, in vitro and in vivo studies suggest vitamin D favorably influences blood pressure and blood glucose control, strong risk factors for diabetic retinopathy. We examined the association between vitamin D status and prevalent diabetic retinopathy in participants with diabetes from a population-based cohort. METHODS: Among participants in the Atherosclerosis Risk in Communities (ARIC) study with diabetes at visit 3 (1993-1995), 1339 (906 Caucasians, 433 African Americans) had serum 25-hydroxyvitamin (25[OH]D) concentrations assessed at visit 2 (1989-1992) and nonmydriatic retinal photographs taken at visit 3...
September 1, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27536155/the-association-between-vitamin-d-receptor-gene-polymorphisms-taqi-and-foki-type-2-diabetes-and-micro-macrovascular-complications-in-postmenopausal-women
#5
Juliana Maia, Andreia Soares da Silva, Rodrigo Feliciano do Carmo, Taciana Furtado de Mendonça, Luiz Henrique Maciel Griz, Patricia Moura, Francisco Bandeira
INTRODUCTION: Since there is evidence of the action of vitamin D as a modulator of insulin release and atherosclerosis, it may well be that the vitamin D receptor polymorphisms are associated with diabetes and its chronic complications. AIMS: To examine the associations between vitamin D receptor polymorphisms (FokI and TaqI) and Type 2 diabetes (T2DM) and its associated chronic complications in postmenopausal women. METHODS: This cross-sectional study analyzed 100 postmenopausal women with T2DM (mean age 65...
2016: Application of Clinical Genetics
https://www.readbyqxmd.com/read/27504517/nutrition-in-the-preterm-infant-what%C3%A2-s-new
#6
Jemma S Cleminson, Stefan P Zalewski, Nicholas D Embleton
PURPOSE OF REVIEW: The increasing recognition of the role of nutritional care for preterm infants continues to result in a proliferation of review articles, systematic reviews, observational studies and trials. In this article, we review a selection of important studies published in the last 12–18 months. RECENT FINDINGS: The selected studies demonstrate the potential importance of light protecting parenteral nutrition solutions, the benefits of standardized concentrated parenteral nutrition solutions and the importance of insulin-like growth factor I in early life...
May 2016: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/27436228/does-vitamin-d-have-any-role-in-the-improvement-of-diabetic-peripheral-neuropathy-in-type-1-diabetic-patients
#7
U Ozuguz, S Oruc, M S Ulu, H Demirbas, A Acay, B Coker, B Beyazıt, M Yaman, T Koken
AIM: The aim of this study was to evaluate the relationship between diabetic peripheral neuropathy (DPN) and vitamin D, nerve growth factor (NGF) and oxidative stress markers in patients with type 1 diabetes. METHODS: Ninety-six patients with type 1 diabetes were included in the study. All patients were evaluated for DPN with Michigan Neuropathy Screening Instrument. Fasting blood glucose, HbA1c, lipid parameters, 25 (OH) D3, NGF, total oxidant status, total antioxidant status and oxidative stress index were measured...
July 19, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27381964/the-role-of-vitamin-d-obesity-and-physical-exercise-in-regulation-of-glycemia-in-type-2-diabetes-mellitus-patients
#8
Abdulbari Bener, Abdulla O A A Al-Hamaq, Eda Merve Kurtulus, Waleed K Abdullatef, Mahmoud Zirie
AIM: The aims of this study were to determine the role of vitamin D, obesity and physical exercise in the regulation of glycemia in Type 2 Diabetes Mellitus patients in a highly consanguineous population. DESIGN: Case and control study. SETTING: The survey was carried out at the Hamad General Hospital and Primary Health Care (PHC) centers in the State of Qatar. SUBJECTS: The study was conducted from November 2012 to June 2014 among subjects above 30 years of age...
October 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27277135/non-traumatic-lower-limb-amputation-in-patients-with-end-stage-renal-failure-on-dialysis-an-australian-perspective
#9
Rajit A Gilhotra, Beverly T Rodrigues, Venkat N Vangaveti, George Kan, David Porter, Kunwarjit S Sangla, Usman H Malabu
BACKGROUND: End-stage renal failure (ESRF) and dialysis have been identified as a risk factor for lower limb amputations (LLAs). High rate of ESRF amongst the Australian population has been reported, however till date no study has been published identifying magnitude and risk factors of LLA in subjects on renal dialysis. OBJECTIVE: The study aims to document trends in the prevalence and identify risk factors of non-traumatic LLA in Australian patients on dialysis...
August 2016: Renal Failure
https://www.readbyqxmd.com/read/26894581/serum-25-hydroxyvitamin-d-levels-and-dry-eye-syndrome-differential-effects-of-vitamin-d-on-ocular-diseases
#10
Donghyun Jee, Seungbum Kang, Changzheng Yuan, Eunyoung Cho, Jorge G Arroyo
PURPOSE: To investigate associations between serum 25-hydroxyvitamin D levels and dry eye syndrome (DES), and to evaluate the differential effect of vitamin D on ocular diseases including age-related macular disease (AMD), diabetic retinopathy (DR), cataract, and DES. METHODS: A total of 16,396 participants aged >19 years were randomly selected from the Korean National Health and Nutrition Examination Survey. All participants participated in standardized interviews, blood 25-hydroxyvitamin D level evaluations, and comprehensive ophthalmic examinations...
2016: PloS One
https://www.readbyqxmd.com/read/26885530/vitamin-d-deficiency-is-not-associated-with-diabetic-retinopathy-or-maculopathy
#11
Uazman Alam, Yasar Amjad, Anges Wan Shan Chan, Omar Asghar, Ioannis N Petropoulos, Rayaz A Malik
BACKGROUND: Experimental and clinical studies suggest a possible association between vitamin D deficiency and both diabetic retinopathy and maculopathy. METHODS: We have performed a cross-sectional study in adults with types 1 and 2 diabetes mellitus. The relationship between the presence and severity of diabetic retinopathy and maculopathy with serum 25-hydroxyvitamin D concentration was evaluated using logistic regression analyses in the presence of demographic and clinical covariates...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26826427/relationship-between-vitamin-d-status-and-vascular-complications-in-patients-with-type-2-diabetes-mellitus
#12
Chan-Hee Jung, Kyu-Jin Kim, Bo-Yeon Kim, Chul-Hee Kim, Sung Koo Kang, Ji-Oh Mok
We aimed to investigate the association between serum 25-hydroxyvitamin D (25[OH]D) and microvascular complications in type 2 diabetes mellitus (T2DM) patients. It was hypothesized that lower 25(OH)D would be associated with increased microvascular complications in T2DM. A total of 257 T2DM patients (111 men, 146 women) who underwent diabetic microvascular complication (peripheral neuropathy, nephropathy, retinopathy) studies were recruited. Patients were categorized into 3 groups according to vitamin D status: vitamin D sufficient (n = 41, 25[OH]D ≥ 20 ng/mL), vitamin D insufficient (n = 132, 10 ≤ 25[OH]D < 20 ng/mL), and vitamin D deficient (n = 84, 25[OH]D < 10 ng/mL)...
February 2016: Nutrition Research
https://www.readbyqxmd.com/read/26790383/association-between-bsm1-polymorphism-in-vitamin-d-receptor-gene-and-diabetic-retinopathy-of-type-2-diabetes-in-korean-population
#13
Yong Joo Hong, Eun Seok Kang, Myoung Jin Ji, Hyung Jin Choi, Taekeun Oh, Sung Soo Koong, Hyun Jeong Jeon
BACKGROUND: Type 2 diabetes is one of the most common diseases with devastating complications. However, genetic susceptibility of diabetic complications has not been clarified. The vitamin D endocrine system is related with calcification and lipolysis, insulin secretion, and may be associated with many complicated disease including diabetes and cardiovascular disease. Recent studies reported that single nucleotide polymorphisms of vitamin D receptor (VDR) gene were associated with diabetic complications...
December 2015: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26590088/ascorbic-acid-prevents-vegf-induced-increases-in-endothelial-barrier-permeability
#14
Esad Ulker, William H Parker, Amita Raj, Zhi-chao Qu, James M May
Vascular endothelial growth factor (VEGF) increases endothelial barrier permeability, an effect that may contribute to macular edema in diabetic retinopathy. Since vitamin C, or ascorbic acid, can tighten the endothelial permeability barrier, we examined whether it could prevent the increase in permeability due to VEGF in human umbilical vein endothelial cells (HUVECs). As previously observed, VEGF increased HUVEC permeability to radiolabeled inulin within 60 min in a concentration-dependent manner. Loading the cells with increasing concentrations of ascorbate progressively prevented the leakage caused by 100 ng/ml VEGF, with a significant inhibition at 13 µM and complete inhibition at 50 µM...
January 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/26447978/retinal-nerve-fiber-layer-thickness-in-early-stage-diabetic-retinopathy-with-vitamin-d-deficiency
#15
Adem Gungor, Orhan Ates, Habib Bilen, Ibrahim Kocer
PURPOSE: To evaluate retinal nerve fiber layer (RNFL) thickness in early-stage diabetic retinopathy (DR) patients with and without vitamin D deficiency (VDD). METHODS: This study compared 50 early-stage DR patients with VDD (group 1) and 50 early-stage DR patients without VDD (group 2). All patients were examined by the same ophthalmologist. Mean RNFL thickness was determined by optical coherence tomography (OCT) performed by the two independent ophthalmologists for all subjects...
October 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26165427/natural-nrf2-activators-in-diabetes
#16
REVIEW
Angélica Saraí Jiménez-Osorio, Susana González-Reyes, José Pedraza-Chaverri
Prediabetes and diabetes are rising worldwide. Control of blood glucose is crucial to prevent or delay diabetic complications that frequently result in increased morbidity and mortality. Most strategies include medical treatment and changes in lifestyle and diet. Some nutraceutical compounds have been recognized as adjuvants in diabetes control. Many of them can activate the nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which has been recognized as a master regulator of the antioxidant response. Recent studies have described the role of Nrf2 in obesity, metabolic syndrome, nephropathy, retinopathy and neuropathy, where its activation prevents the development of diabetes and its complications...
August 25, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/26089210/the-diabetes-visual-function-supplement-study-divfuss
#17
RANDOMIZED CONTROLLED TRIAL
A Paul Chous, Stuart P Richer, Jeffry D Gerson, Renu A Kowluru
BACKGROUND: Diabetes is known to affect visual function before onset of retinopathy (diabetic retinopathy (DR)). Protection of visual function may signal disruption of mechanisms underlying DR. METHODS: This was a 6-month randomised, controlled clinical trial of patients with type 1 and type 2 diabetes with no retinopathy or mild to moderate non-proliferative retinopathy assigned to twice daily consumption of placebo or a novel, multi-component formula containing xanthophyll pigments, antioxidants and selected botanical extracts...
February 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/26078978/vitamin-d-deficiency-is-associated-with-the-presence-and-severity-of-diabetic-retinopathy-in-type-2-diabetes-mellitus
#18
Nuria Alcubierre, Joan Valls, Esther Rubinat, Gonzalo Cao, Aureli Esquerda, Alicia Traveset, Minerva Granado-Casas, Carmen Jurjo, Didac Mauricio
There is very few evidences on the role of vitamin D in the development of diabetic retinopathy. The aim of the current study was to explore whether there is an association of vitamin D status and diabetic retinopathy in type 2 diabetes. Two groups of patients were selected: 139 and 144 patients with and without retinopathy, respectively, as assessed by an experienced ophthalmologist. Subjects with advanced late diabetic complications were excluded to avoid confounding biases. 25-Hydroxy-vitamin D3 (25(OH)D) concentrations and vitamin D deficiency were associated with the presence of diabetic retinopathy...
2015: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26059368/plasma-vitamin-d-status-in-patients-with-type-2-diabetes-with-and-without-retinopathy
#19
G Bhanuprakash Reddy, M Sivaprasad, T Shalini, A Satyanarayana, M Seshacharyulu, N Balakrishna, K Viswanath, Manisha Sahay
OBJECTIVE: Diabetic retinopathy (DR) is a common cause of blindness. Although an association between hypovitaminosis D and type 1 diabetes is known, the association between vitamin D (VD) and type 2 diabetes (T2D) and its complications such as DR has been unclear. The aim of this study was to investigate the status of VD in T2D patients with and without DR. METHODS: A cross-sectional case-control study was conducted with 99 normal control (CN) participants and 164 patients with T2D, of which 82 had retinopathy (DR) and 82 did not (DNR)...
July 2015: Nutrition
https://www.readbyqxmd.com/read/26054653/modulatory-effects-of-1-25-dihydroxyvitamin-d3-on-eye-disorders-a-critical-review
#20
Marcella Nebbioso, Giuseppe Buomprisco, Antonia Pascarella, Nicola Pescosolido
Many studies have shown that the presence of 1,25-dihydroxyvitamin D3 in the eye is able to modulate inflammatory responses. In fact, it has been demonstrated that topical administration of vitamin D3 inhibits Langerhans cells migration from the central cornea, corneal neovascularization, and production of cytokines (i.e. interleukin-1-6-8) in experimental animals. Moreover, both in vitro and in vivo studies have demonstrated that vitamin D is a potent inhibitor of retinal neovascularization. It has been shown that calcitriol, the biologically active form of vitamin D, inhibits angiogenesis both in cultured endothelial cells and in retinas from guinea pigs with retinoblastoma or oxygen-induced ischemic retinopathy...
June 9, 2015: Critical Reviews in Food Science and Nutrition
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